Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof

ABSTRACT

The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation application of U.S. non-provisional application Ser. No. 14/834,946, filed Aug. 25, 2015, which is a continuation application of U.S. non-provisional application Ser. No. 13/833,905, filed Mar. 15, 2013, which is a continuation application of U.S. non-provisional application Ser. No. 13/085,955, filed Apr. 13, 2011, which claims the benefit of U.S. provisional application Ser. No. 61/325,689 filed Apr. 19, 2010, U.S. provisional application Ser. No. 61/332,509 filed May 7, 2010, and U.S. provisional application Ser. No. 61/405,972 filed Oct. 22, 2010, the contents of each of which are hereby incorporated by reference in their entirety into this application.

FIELD OF THE INVENTION

The present invention is in the field of drug response and disease risk, particularly genetic polymorphisms that are associated with response to statins, especially for the prevention or treatment of cardiovascular diseases (CVD) such as coronary heart disease (CHD) (which includes coronary events such as myocardial infarction (MI)) and cerebrovascular events (such as stroke). In particular, the present invention relates to specific single nucleotide polymorphisms (SNPs) in the human genome, and their association with variability in responsiveness to statin treatment (including preventive treatment) in reducing CVD risk between different individuals. These SNPs are also useful for assessing an individual's risk for developing CVD. The SNPs disclosed herein can be used, for example, as targets for diagnostic reagents and for the development of therapeutic agents. In particular, the SNPs of the present invention are useful for such uses as predicting an individual's response to therapeutic agents such as evaluating the likelihood of an individual differentially responding positively to statins, particularly for the treatment or prevention of CVD (particularly CHD such as MI, as well as stroke), identifying an individual who has an increased or decreased risk of developing CVD (particularly CHD such as MI, as well as stroke), for early detection of the disease, for providing clinically important information for the prevention and/or treatment of CVD, for predicting recurrence of CVD, and for screening and selecting therapeutic agents. Methods, assays, kits, and reagents for detecting the presence of these polymorphisms and their encoded products are provided.

BACKGROUND OF THE INVENTION

The present invention relates to SNPs that are associated with variability between individuals in their response to statins, particularly for the prevention or treatment of cardiovascular disease (CVD), which includes coronary heart disease (CHD) (which further includes myocardial infarction (MI) and other coronary events) and cerebrovascular events such as stroke and transient ischemic attack (TIA). These SNPs are also useful for determining an individual's risk for developing CVD, particularly CHD (including coronary events such as MI) as well as cerebrovascular events (such as stroke and TIA).

HMG-CoA Reductase Inhibitors (Statins)

HMG-CoA reductase inhibitors (statins) are used for the treatment and prevention of CVD, particularly CHD (including coronary events such as MI) and cerebrovascular events (such as stroke). Reduction of MI, stroke, and other coronary and cerebrovascular events and total mortality by treatment with HMG-CoA reductase inhibitors has been demonstrated in a number of randomized, double-blinded, placebo-controlled prospective trials (D. D. Waters, Clin Cardiol 24(8 Suppl):III3-7 (2001); B. K. Singh and J. L. Mehta, Curr Opin Cardiol 17(5):503-11 (2002)). These drugs are thought to typically have their primary effect through the inhibition of hepatic cholesterol synthesis, thereby upregulating LDL receptors in the liver. The resultant increase in LDL catabolism results in decreased circulating LDL, a major risk factor for cardiovascular disease.

Examples of statins include, but are not limited to, atorvastatin (Lipitor®), rosuvastatin (Crestor®), pravastatin (Pravachol®), simvastatin (Zocor®), fluvastatin (Lescol®), and lovastatin (Mevacor®), as well as combination therapies that include a statin such as simvastatin+ezetimibe (Vytorin®), lovastatin+niacin (Advicor®), atorvastatin+amlodipine besylate (Caduet®), and simvastatin+niacin (Simcor®).

Statins can be divided into two types according to their physicochemical and pharmacokinetic properties. Statins such as atorvastatin, simvastatin, lovastatin, and cerivastatin are lipophilic in nature and, as such, diffuse across membranes and thus are highly cell permeable. Hydrophilic statins such as pravastatin are more polar, such that they require specific cell surface transporters for cellular uptake. K. Ziegler and W. Stunkel, Biochim Biophys Acta 1139(3):203-9 (1992); M. Yamazaki et al., Am J Physiol 264(1 Pt 1):G36-44 (1993); T. Komai et al., Biochem Pharmacol 43(4):667-70 (1992). The latter statins utilizes a transporter, OATP2, whose tissue distribution is confined to the liver and, therefore, they are relatively hepato-specific inhibitors. B. Hsiang et al., J Biol Chem 274(52):37161-37168 (1999). The former statins, not requiring specific transport mechanisms, are available to all cells and they can directly impact a much broader spectrum of cells and tissues. These differences in properties may influence the spectrum of activities that each statin possesses. Pravastatin, for instance, has a low myopathic potential in animal models and myocyte cultures compared to lipophilic statins. B. A. Masters et al., Toxicol Appl Pharmacol 131(1): 163-174 (1995); K. Nakahara et al., Toxicol Appl Pharmacol 152(1):99-106 (1998); J. C. Reijneveld et al., Pediatr Res 39(6):1028-1035 (1996). Statins are reviewed in Vaughan et al., “Update on Statins: 2003”, Circulation 2004; 110; 886-892.

Evidence from gene association studies is accumulating to indicate that responses to drugs are, indeed, at least partly under genetic control. As such, pharmacogenetics—the study of variability in drug responses attributed to hereditary factors in different populations—may significantly assist in providing answers toward meeting this challenge. A. D. Roses, Nature 405(6788):857-865 (2000); V. Mooser et al., J Thromb Haemost 1(7):1398-1402 (2003); L. M. Humma and S. G. Terra, Am J Health Syst Pharm 59(13):1241-1252 (2002). Associations have been reported between specific genotypes, as defined by SNPs and other genetic sequence variations, and specific responses to cardiovascular drugs. For example, a polymorphism in the KIF6 gene is associated with response to statin treatment (lakoubova et al., “Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study”, J Am Coll Cardiol. 2008 Jan. 29; 51(4):449-55; lakoubova et al., “Association of the 719Arg variant of KIF6 with both increased risk of coronary events and with greater response to statin therapy”, J Am Coll Cardiol. 2008 Jun. 3; 51(22):2195; lakoubova et al., “KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study”, Eur J Cardiovasc Prev Rehabil. 2010 Apr. 20; and Shiffman et al., “Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial”, Am J Cardiol. 2010 May 1; 105(9):1300-5).

There is a need for genetic markers that can be used to predict an individual's responsiveness to statins. For example, there is a growing need to better identify people who have a high chance of benefiting from statins, and those who have a low risk of developing side-effects. For example, severe myopathies represent a significant risk for a low percentage of the patient population, and this may be a particular concern for patients who are treated more aggressively with statins. Furthermore, different patients may have the same the risk for adverse events but are more likely to benefit from a drug (such as statins) and this may justify use of the drug in those individuals who are more likely to benefit. Similarly, in individuals who are less likely to benefit from a drug but are at risk for adverse events, use of the drug in these individuals can be de-prioritized or delayed.

An example of a large trial which analyzed the benefits of statin treatment for reducing the risk of CVD in a large population was the JUPITER Study (described in Ridker et al., “Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein”, N Engl J Med. 2008 Nov. 20; 359(21):2195-207), which demonstrated that rosuvastatin (Crestor®) significantly reduced the incidence of major cardiovascular events (including MI, stroke, arterial revascularization, hospitalization for unstable angina, and death from cardiovascular causes) in a study of 17,802 individuals.

The benefits of using statins for stroke is also described in O'Regan et al., “Statin therapy in stroke prevention: a meta-analysis involving 121,000 patients”, Am J Med. 2008 January; 121(1):24-33 and Everett et al., “Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)”, Circulation. 2010 Jan. 5; 121(1):143-50.

Cardiovascular Disease (CVD), Including Coronary Heart Disease (CHD) and Stroke

Cardiovascular disease (CVD) includes coronary heart disease (CHD) (which further includes myocardial infarction (MI) and other coronary events) and cerebrovascular events such as stroke and transient ischemic attack (TIA).

Coronary heart disease (CHD) is defined herein as encompassing MI (fatal or non-fatal) and other coronary events, death from coronary disease, angina pectoris (particularly unstable angina), and coronary stenosis. The presence of CHD may be indicated by the occurrence of medical interventions such as coronary revascularization, which can include percutaneous transluminal coronary angioplasty (PTCA), coronary stent placement, and coronary artery bypass graft (CABG). Cardiovascular disease (CVD) is defined herein as encompassing CHD as well as cerebrovascular events such as stroke and transient ischemic attack (TIA).

Myocardial Infarction (MI)

Myocardial infarction (MI) is encompassed within CHD. MI, also referred to as a “heart attack”, is the most common cause of mortality in developed countries. The incidence of MI is still high despite currently available preventive measures and therapeutic intervention. More than 1,500,000 people in the U.S. suffer acute MI each year, many without seeking help due to unrecognized MI, and one third of these people die. The lifetime risk of coronary artery disease events at age 40 is 42.4% for men, nearly one in two, and 24.9% for women, or one in four (D. M. Lloyd-Jones, Lancet 353:89-92 (1999)).

MI is a multifactorial disease that involves atherogenesis, thrombus formation and propagation. Thrombosis can result in complete or partial occlusion of coronary arteries. The luminal narrowing or blockage of coronary arteries reduces oxygen and nutrient supply to the cardiac muscle (cardiac ischemia), leading to myocardial necrosis and/or stunning. MI, unstable angina, and sudden ischemic death are clinical manifestations of cardiac muscle damage. All three endpoints are part of acute coronary syndrome since the underlying mechanisms of acute complications of atherosclerosis are considered to be the same.

Atherogenesis, the first step of pathogenesis of MI, is an interaction between blood elements, mechanical forces, disturbed blood flow, and vessel wall abnormality that results in plaque accumulation. An unstable (vulnerable) plaque is an underlying cause of arterial thrombotic events and MI. A vulnerable plaque is a plaque, often not stenotic, that has a high likelihood of becoming disrupted or eroded, thus forming a thrombogenic focus. The “vulnerability” of an individual to MI may be due to vulnerable plaque, blood vulnerability (hypercoagulation, hypothrombolysis), and heart vulnerability (sensitivity of the heart to ischemia or propensity for arrhythmia). Recurrent myocardial infarction (RMI) can generally be viewed as a severe form of MI progression caused by multiple vulnerable plaques that are able to undergo pre-rupture or a pre-erosive state, coupled with extreme blood coagulability.

The current diagnosis of MI with presentation (rather than to predict if MI is likely to occur in the future) is based on the levels of troponin I or T that indicate the cardiac muscle progressive necrosis, impaired electrocardiogram (ECG), and detection of abnormal ventricular wall motion or angiographic data (the presence of acute thrombi). However, due to the asymptomatic nature of 25% of acute MIs (absence of atypical chest pain, low ECG sensitivity), a significant portion of MIs are not diagnosed and therefore not treated appropriately (e.g., prevention of recurrent MIs).

MI risk assessment and prognosis is currently done using classic risk factors or the recently introduced Framingham Risk Index. Both of these assessments put a significant weight on LDL levels to justify preventive treatment. However, it is well established that half of all MIs occur in individuals without overt hyperlipidemia.

Other emerging risk factors of MI are inflammatory biomarkers such as C-reactive protein (CRP), ICAM-1, SAA, TNF c, homocysteine, impaired fasting glucose, new lipid markers (ox LDL, Lp-a, MAD-LDL, etc.) and pro-thrombotic factors (fibrinogen, PAI-1). These markers have significant limitations such as low specificity and low positive predictive value, and the need for multiple reference intervals to be used for different groups of people (e.g., males-females, smokers-non smokers, hormone replacement therapy users, different age groups). These limitations diminish the utility of such markers as independent prognostic markers for MI screening.

Genetics plays an important role in MI risk. Families with a positive family history of MI account for 14% of the general population, 72% of premature MIs, and 48% of all MIs (R. R. Williams, Am J Cardiology 87:129 (2001)). Associations have been reported between genetic polymorphisms and MI risk. For example, polymorphism in the KIF6, LPA, and other genes and chromosomal regions are associated with MI risk (Shiffman et al., “Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study”, Arterioscler Thromb Vasc Biol. 2008 January; 28(1):173-9; Bare et al., “Five common gene variants identify elevated genetic risk for coronary heart disease”, Genet Med. 2007 October; 9(10):682-9; Iakoubova et al., “Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials”, J Am Coll Cardiol. 2008 Jan. 29; 51(4):435-43; and Shiffman et al., “A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study”, J Am Coll Cardiol. 2008 Jan. 29; 51(4):444-8.

Genetic markers such as single nucleotide polymorphisms (SNPs) are preferable to other types of biomarkers. Genetic markers that are prognostic for MI can be genotyped early in life and could predict individual response to various risk factors. The combination of serum protein levels and genetic predisposition revealed by genetic analysis of susceptibility genes can provide an integrated assessment of the interaction between genotypes and environmental factors, resulting in synergistically increased prognostic value of diagnostic tests.

Thus, there is an urgent need for novel genetic markers that are predictive of predisposition to CHD such as MI, particularly for individuals who are unrecognized as having a predisposition to MI. Such genetic markers may enable prognosis of MI in much larger populations compared with the populations that can currently be evaluated by using existing risk factors and biomarkers. The availability of a genetic test may allow, for example, appropriate preventive treatments for acute coronary events to be provided for susceptible individuals (such preventive treatments may include, for example, statin treatments and statin dose escalation, as well as changes to modifiable risk factors), lowering of the thresholds for ECG and angiography testing, and allow adequate monitoring of informative biomarkers. Moreover, the discovery of genetic markers associated with MI can provide novel targets for therapeutic intervention or preventive treatments of MI, and enable the development of new therapeutic agents for treating or preventing MI and other cardiovascular disorders.

Furthermore, novel genetic markers that are predictive of predisposition to MI can be particularly useful for identifying individuals who are at risk for early-onset MI. “Early-onset MI” may be defined as MI in men who are less than 55 years of age and women who are less than 65 years of age (K. O. Akosah et al., “Preventing myocardial infarction in the young adult in the first place: How do the National Cholesterol Education Panel III guidelines perform?” JACC 41(9): 1475-1479 (2003)). Individuals who experience early-onset MI may not be effectively identified by current cholesterol treatment guidelines, such as those suggested by the National Cholesterol Education Program. In one study, for example, a significant number of individuals who suffered MI at an earlier age (≤50 years) were shown to have LDL cholesterol below 100 mg/dl (K. O. Akosah et al., “Myocardial infarction in young adults with low-density lipoprotein cholesterol levels less than or equal to 100 mg/dl. Clinical profile and 1-year outcomes.” Chest 120:1953-1958 (2001)). Because risk for MI can be reduced by lifestyle changes and by treatment of modifiable risk factors, better methods to identify individuals at risk for early-onset MI could be useful for making preventive treatment decisions, especially considering that these patients may not be identified for medical management by conventional treatment guidelines. Genetic markers for risk of early-onset MI could potentially be incorporated into individual risk assessment protocols, as they have the advantage of being easily detected at any age.

Stroke

Stroke is a prevalent and serious cerebrovascular disease. It affects 4.7 million individuals in the United States, with 500,000 first attacks and 200,000 recurrent cases yearly. Approximately one in four men and one in five women aged 45 years will have a stroke if they live to their 85th year. About 25% of those who have a stroke die within a year. Stroke is the third leading cause of mortality in the United States and is responsible for 170,000 deaths a year. Among those who survive a stroke attack, 30 to 50% do not regain functional independence. Stroke therefore is the most common cause of disability and the second leading cause of dementia (Heart Disease and Stroke Statistics—2004 Update, American Heart Association).

Stroke occurs when an artery bringing oxygen and nutrients to the brain either ruptures, causing hemorrhagic stroke, or gets occluded, causing ischemic stroke. Ischemic stroke can be caused by thrombi formation at the site of an atherosclerotic plaque rupture (this type of ischemic stroke is interchangeably referred to as thrombotic or atherothrombotic stroke) or by emboli (clots) that have travelled from another part of the vasculature (this type of ischemic stroke is referred to as embolic stroke), often from the heart (this type of embolic stroke may be referred to as cardioembolic stroke). In both ischemic and hemorrhagic stroke, a cascade of cellular changes due to ischemia or increased cranial pressure leads to injuries or death of the brain cells. In the United States, the majority (about 80-90%) of stroke cases are ischemic (Rathore, et al., Stroke 33:2718-2721 ((2002)), including 30% large-vessel thrombotic (also referred to as large-vessel occlusive disease), 20% small-vessel thrombotic (also referred to as small-vessel occlusive disease), and 30% embolic or cardiogenic (caused by a clot originating from elsewhere in the body, e.g., from blood pooling due to atrial fibrillation, or from carotid artery stenosis). The ischemic form of stroke results from obstruction of blood flow in cerebral blood vessels, and it shares common pathological etiology with atherosclerosis and thrombosis.

About 10-20% of stroke cases are of the hemorrhagic type (Rathore, et al., Stroke 33:2718-2721 ((2002)), involving bleeding within or around the brain. Bleeding within the brain is known as cerebral hemorrhage, which is often linked to high blood pressure. Bleeding into the meninges surrounding the brain is known as a subarachnoid hemorrhage, which could be caused by a ruptured cerebral aneurysm, an arteriovenous malformation, or a head injury. The hemorrhagic stroke, although less prevalent, poses a greater danger. Whereas about 8% of ischemic stroke cases result in death within 30 days, about 38% of hemorrhagic stroke cases result in death within the same time period (Collins, et al., J. Clin. Epidemiol. 56:81-87 (2003)).

Transient ischemic attack (TIA) is a condition related to stroke. According to the National Institute of Neurological Disorders and Stroke (NINDS), “A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination”. NINDS further states that, “TIAs are often warning signs that a person is at risk for a more serious and debilitating stroke. About one-third of those who have a TIA will have an acute stroke some time in the future. Many strokes can be prevented by heeding the warning signs of TIAs and treating underlying risk factors.”

Known risk factors for stroke or TIA can be divided into modifiable and non-modifiable risk factors. Older age, male sex, black or Hispanic ethnicity, and family history of stroke are non-modifiable risk factors. Modifiable risk factors include hypertension, smoking, increased insulin levels, asymptomatic carotid disease, cardiac vessel disease, and hyperlipidemia.

Multiple reports based on twin studies (Brass et al., Stroke. 1992; 23:221-223 and Bak et al., Stroke. 2002; 33:769-774) and family studies (Welin L, et al. N Engl J Med. 1987; 317:521-526 and Jousilahti et al., Stroke. 1997; 28:1361-136) have shown that genetics contributes to risk of stroke independently of traditional risk factors. A number of genetic markers have been reported to be associated with stroke. For example, SNPs in the 4q25 region were reported to be associated with stroke (Gretarsdottir et al., “Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke”, Ann Neurol. 2008; 64:402-409) and with atrial fibrillation (AF) (Gudbjartsson et al., “Variants conferring risk of atrial fibrillation on chromosome 4q25”, Nature. 2007; 448:353-357), SNPs in the 16q22 region (Gudbjartsson et al., “A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke”, Nat Genet. 2009; 41:876-878) and in the 9p21 region were found to be associated with noncardioembolic or atherothrombotic stroke (Luke et al., “Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry”, Cerebrovasc Dis. 2009; 28:499-504 and Gschwendtner et al., “Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke”, Ann Neurol. 2009; 65:531-539), and variants in the 12p13 region were associated with stroke in general and with atherothrombotic stroke in particular (Ikram et al., “Genomewide association studies of stroke”, N Engl J Med. 2009; 360:1718-1728).

The acute nature of stroke leaves physicians with little time to prevent or lessen the devastation of brain damage. Strategies to diminish the impact of stroke include prevention and treatment with thrombolytic and, possibly, neuroprotective agents. The success of preventive measures will depend on the identification of risk factors in individual patients and means to modulate their impact.

Although some risk factors for stroke or TIA are not modifiable, such as age and family history, other underlying pathology or risk factors of stroke or TIA such as atherosclerosis, hypertension, smoking, diabetes, aneurysm, and atrial fibrillation, are chronic and amenable to effective life-style changes, pharmacological interventions, as well as surgical treatments. Early recognition of patients with informative risk factors, and especially those with a family history, using a non-invasive test of genetic markers associated with stroke can enable physicians to target the highest risk individuals for aggressive risk reduction.

Thus, there is a need for the identification of genetic markers that are predictive of an individual's predisposition to stroke or TIA and other vascular diseases. Furthermore, the identification of genetic markers which are useful for identifying individuals who are at an increased risk of having a stroke may lead to, for example, better preventive and therapeutic strategies, economic models, and health care policy decisions.

Single Nucleotide Polymorphisms (SNPs)

The genomes of all organisms undergo spontaneous mutations in the course of their continuing evolution, generating variant forms of progenitor genetic sequences. Gusella, Ann Rev Biochem 55:831-854 (1986). A variant form may confer an evolutionary advantage or disadvantage relative to a progenitor form or may be neutral. In some instances, a variant form confers an evolutionary advantage to individual members of a species and is eventually incorporated into the DNA of many or most members of the species and effectively becomes the progenitor form. Additionally, the effects of a variant form may be both beneficial and detrimental, depending on the environment. For example, a heterozygous sickle cell mutation confers resistance to malaria, but a homozygous sickle cell mutation is usually lethal. In many cases, both progenitor and variant forms survive and co-exist in a species population. The coexistence of multiple forms of a genetic sequence segregating at appreciable frequencies is defined as a genetic polymorphism, which includes single nucleotide polymorphisms (SNPs).

Approximately 90% of all genetic polymorphisms in the human genome are SNPs. SNPs are single base positions in DNA at which different alleles, or alternative nucleotides, exist in a population. The SNP position (interchangeably referred to herein as SNP, SNP site, SNP locus, SNP marker, or marker) is usually preceded by and followed by highly conserved sequences (e.g., sequences that vary in less than 1/100 or 1/1000 members of the populations). An individual may be homozygous or heterozygous for an allele at each SNP position. A SNP can, in some instances, be referred to as a “cSNP” to denote that the nucleotide sequence containing the SNP is an amino acid coding sequence.

A SNP may arise from a substitution of one nucleotide for another at the polymorphic site. Substitutions can be transitions or transversions. A transition is the replacement of one purine nucleotide by another purine nucleotide, or one pyrimidine by another pyrimidine. A transversion is the replacement of a purine by a pyrimidine, or vice versa. A SNP may also be a single base insertion or deletion variant referred to as an “indel.” Weber et al., “Human diallelic insertion/deletion polymorphisms,” Am J Hum Genet 71(4):854-62 (October 2002).

A synonymous codon change, or silent mutation/SNP (terms such as “SNP”, “polymorphism”, “mutation”, “mutant”, “variation”, and “variant” are used herein interchangeably), is one that does not result in a change of amino acid due to the degeneracy of the genetic code. A substitution that changes a codon coding for one amino acid to a codon coding for a different amino acid (i.e., a non-synonymous codon change) is referred to as a missense mutation. A nonsense mutation results in a type of non-synonymous codon change in which a stop codon is formed, thereby leading to premature termination of a polypeptide chain and a truncated protein. A read-through mutation is another type of non-synonymous codon change that causes the destruction of a stop codon, thereby resulting in an extended polypeptide product. While SNPs can be bi-, tri-, or tetra-allelic, the vast majority of SNPs are bi-allelic, and are thus often referred to as “bi-allelic markers,” or “di-allelic markers.”

As used herein, references to SNPs and SNP genotypes include individual SNPs and/or haplotypes, which are groups of SNPs that are generally inherited together. Haplotypes can have stronger correlations with diseases or other phenotypic effects compared with individual SNPs, and therefore may provide increased diagnostic accuracy in some cases. Stephens et al., Science 293:489-493 (July 2001).

Causative SNPs are those SNPs that produce alterations in gene expression or in the expression, structure, and/or function of a gene product, and therefore are most predictive of a possible clinical phenotype. One such class includes SNPs falling within regions of genes encoding a polypeptide product, i.e. cSNPs. These SNPs may result in an alteration of the amino acid sequence of the polypeptide product (i.e., non-synonymous codon changes) and give rise to the expression of a defective or other variant protein. Furthermore, in the case of nonsense mutations, a SNP may lead to premature termination of a polypeptide product. Such variant products can result in a pathological condition, e.g., genetic disease. Examples of genes in which a SNP within a coding sequence causes a genetic disease include sickle cell anemia and cystic fibrosis.

Causative SNPs do not necessarily have to occur in coding regions; causative SNPs can occur in, for example, any genetic region that can ultimately affect the expression, structure, and/or activity of the protein encoded by a nucleic acid. Such genetic regions include, for example, those involved in transcription, such as SNPs in transcription factor binding domains, SNPs in promoter regions, in areas involved in transcript processing, such as SNPs at intron-exon boundaries that may cause defective splicing, or SNPs in mRNA processing signal sequences such as polyadenylation signal regions. Some SNPs that are not causative SNPs nevertheless are in close association with, and therefore segregate with, a disease-causing sequence. In this situation, the presence of a SNP correlates with the presence of, or predisposition to, or an increased risk in developing the disease. These SNPs, although not causative, are nonetheless also useful for diagnostics, disease predisposition screening, and other uses.

An association study of a SNP and a specific disorder involves determining the presence or frequency of the SNP allele in biological samples from individuals with the disorder of interest, such as CVD, and comparing the information to that of controls (i.e., individuals who do not have the disorder; controls may be also referred to as “healthy” or “normal” individuals) who are preferably of similar age and race. The appropriate selection of patients and controls is important to the success of SNP association studies. Therefore, a pool of individuals with well-characterized phenotypes is extremely desirable.

A SNP may be screened in diseased tissue samples or any biological sample obtained from a diseased individual, and compared to control samples, and selected for its increased (or decreased) occurrence in a specific pathological condition, such as pathologies related to CVD and in particular, CHD (e.g., MI). Once a statistically significant association is established between one or more SNP(s) and a pathological condition (or other phenotype) of interest, then the region around the SNP can optionally be thoroughly screened to identify the causative genetic locus/sequence(s) (e.g., causative SNP/mutation, gene, regulatory region, etc.) that influences the pathological condition or phenotype. Association studies may be conducted within the general population and are not limited to studies performed on related individuals in affected families (linkage studies).

Clinical trials have shown that patient response to treatment with pharmaceuticals is often heterogeneous. There is a continuing need to improve pharmaceutical agent design and therapy. In that regard, SNPs can be used to identify patients most suited to therapy with particular pharmaceutical agents (this is often termed “pharmacogenomics”). Similarly, SNPs can be used to exclude patients from certain treatment due to the patient's increased likelihood of developing toxic side effects or their likelihood of not responding to the treatment. Pharmacogenomics can also be used in pharmaceutical research to assist the drug development and selection process. Linder et al., Clinical Chemistry 43:254 (1997); Marshall, Nature Biotechnology 15:1249 (1997); International Patent Application WO 97/40462, Spectra Biomedical; and Schafer et al., Nature Biotechnology 16:3 (1998).

SUMMARY OF THE INVENTION

Exemplary embodiments of the present invention relate to the identification of SNPs, as well as unique combinations of such SNPs and haplotypes of SNPs, that are associated with variability between individuals in their response to statins, particularly for the prevention or treatment of cardiovascular disease (CVD), which includes coronary heart disease (CHD) (which further includes myocardial infarction (MI) and other coronary events) and cerebrovascular events such as stroke. These SNPs are also useful for determining an individual's risk for developing CVD, particularly CHD (including coronary events such as MI) as well as cerebrovascular events such as stroke. The polymorphisms disclosed herein are directly useful as targets for the design of diagnostic and prognostic reagents and the development of therapeutic and preventive agents for use in the diagnosis, prognosis, treatment, and/or prevention of CVD (particularly CHD, such as MI), as well as for predicting a patient's response to therapeutic agents such as statins, particularly for the treatment or prevention of CVD (particularly CHD, such as MI).

Based on the identification of SNPs associated with variability between individuals in their response to statins, particularly for reducing the risk of CVD such as CHD (e.g., MI) and stroke, exemplary embodiments of the present invention also provide methods of detecting these variants as well as the design and preparation of detection reagents needed to accomplish this task. The invention specifically provides, for example, SNPs associated with responsiveness to statin treatment, isolated nucleic acid molecules (including DNA and RNA molecules) containing these SNPs, variant proteins encoded by nucleic acid molecules containing such SNPs, antibodies to the encoded variant proteins, computer-based and data storage systems containing the novel SNP information, methods of detecting these SNPs in a test sample, methods of identifying individuals who have an altered (i.e., increased or decreased) risk of developing CVD (such as CHD (e.g., MI) or stroke), methods for determining the risk of an individual for recurring CVD (e.g., recurrent MI), methods of treating an individual who has an increased risk for CVD and/or increased likelihood of responding to statin treatment, and methods for identifying individuals (e.g., determining a particular individual's likelihood) who have an altered (i.e., increased or decreased) likelihood of responding to drug treatment (especially statin treatment), particularly drug treatment of CVD (e.g., prevention or treatment of CHD such as MI), based on the presence or absence of one or more particular nucleotides (alleles) at one or more SNP sites disclosed herein or the detection of one or more encoded variant products (e.g., variant mRNA transcripts or variant proteins), methods of screening for compounds useful in the treatment or prevention of CVD, compounds identified by these methods, methods of treating or preventing CVD, etc.

Exemplary embodiments of the present invention further provide methods for selecting or formulating a treatment regimen (e.g., methods for determining whether or not to administer statin treatment to an individual having CVD, or who is at risk for developing CVD in the future, or who has previously had CVD, methods for selecting a particular statin-based treatment regimen such as dosage and frequency of administration of statin, or a particular form/type of statin such as a particular pharmaceutical formulation or statin compound, methods for administering (either in addition to or instead of a statin) an alternative, non-statin-based treatment, such as niacin, fibrates, or ezetimibe (e.g., Zetia® or Ezetrol®), to individuals who are predicted to be unlikely to respond positively to statin treatment, etc.), and methods for determining the likelihood of experiencing toxicity or other undesirable side effects from statin treatment, etc. Various embodiments of the present invention also provide methods for selecting individuals to whom a statin or other therapeutic will be administered based on the individual's genotype, and methods for selecting individuals for a clinical trial of a statin or other therapeutic agent based on the genotypes of the individuals (e.g., selecting individuals to participate in the trial who are most likely to respond positively from the statin treatment and/or excluding individuals from the trial who are unlikely to respond positively from the statin treatment based on their SNP genotype(s), or selecting individuals who are unlikely to respond positively to statins based on their SNP genotype(s) to participate in a clinical trial of another type of drug that may benefit them). Further embodiments of the present invention provide methods for reducing an individual's risk of developing CVD (such as CHD (e.g., MI) or stroke) using statin treatment, including preventing recurring CVD (e.g., recurrent MI) using statin treatment, when said individual carries one or more SNPs identified herein as being associated with statin response.

Tables 1 and 2 provides gene information, references to the identification of transcript sequences (SEQ ID NOS: 1-51), encoded amino acid sequences (SEQ ID NOS: 52-102), genomic sequences (SEQ ID NOS: 177-622), transcript-based context sequences (SEQ ID NOS: 103-176) and genomic-based context sequences (SEQ ID NOS: 623-3661) that contain the SNPs of the present application, and extensive SNP information that includes observed alleles, allele frequencies, populations/ethnic groups in which alleles have been observed, information about the type of SNP and corresponding functional effect, and, for cSNPs, information about the encoded polypeptide product. The actual transcript sequences (SEQ ID NOS: 1-51), amino acid sequences (SEQ ID NOS: 52-102), genomic sequences (SEQ ID NOS: 177-622), transcript-based SNP context sequences (SEQ ID NOS: 103-176), and genomic-based SNP context sequences (SEQ ID NOS: 623-3661) are provided in the Sequence Listing.

In certain exemplary embodiments, the invention provides methods for identifying an individual who has an altered likelihood of responding to statin treatment or an altered risk for developing CVD, particularly CHD or stroke (including, for example, a first incidence and/or a recurrence of the disease, such as primary or recurrent MI), in which the method comprises detecting a single nucleotide polymorphism (SNP) in any one of the nucleotide sequences of SEQ ID NOS: 1-51, SEQ ID NOS: 103-176, SEQ ID NOS: 177-622, and SEQ ID NOS: 623-3661 in said individual's nucleic acids, wherein the SNP is specified in Table 1 and/or Table 2, and the presence of the SNP is indicative of an altered response to statin treatment of an altered risk for CVD in said individual. In certain embodiments, the CVD is CHD, particularly MI. In certain other embodiments, the CVD is stroke. In certain exemplary embodiments of the invention, SNPs that occur naturally in the human genome are provided within isolated nucleic acid molecules. These SNPs are associated with response to statin treatment thereby reducing the risk of CVD, such as CHD (e.g., MI) or stroke, such that they can have a variety of uses in the diagnosis, prognosis, treatment, and/or prevention of CVD, and particularly in the treatment or prevention of CVD using statins. In certain embodiments, a nucleic acid of the invention is an amplified polynucleotide, which is produced by amplification of a SNP-containing nucleic acid template. In another embodiment, the invention provides for a variant protein that is encoded by a nucleic acid molecule containing a SNP disclosed herein.

In further embodiments of the invention, reagents for detecting a SNP in the context of its naturally-occurring flanking nucleotide sequences (which can be, e.g., either DNA or mRNA) are provided. In particular, such a reagent may be in the form of, for example, a hybridization probe or an amplification primer that is useful in the specific detection of a SNP of interest. In an alternative embodiment, a protein detection reagent is used to detect a variant protein that is encoded by a nucleic acid molecule containing a SNP disclosed herein. A preferred embodiment of a protein detection reagent is an antibody or an antigen-reactive antibody fragment. Various embodiments of the invention also provide kits comprising SNP detection reagents, and methods for detecting the SNPs disclosed herein by employing the SNP detection reagents. An exemplary embodiment of the present invention provides a kit comprising a SNP detection reagent for use in determining whether a human's risk for CVD is reduced by treatment with statins based upon the presence or absence of a particular allele of one or more SNPs disclosed herein.

In various embodiments, the present invention provides methods for evaluating whether an individual is likely (or unlikely) to respond to statin treatment (i.e., benefit from statin treatment)), particularly statin treatment for reducing the risk of CVD, particularly CHD (such as MI) or stroke, by detecting the presence or absence of one or more SNP alleles disclosed herein. The present invention also provides methods of identifying an individual having an increased or decreased risk of developing CVD, such as CHD (e.g., MI) or stroke, by detecting the presence or absence of one or more SNP alleles disclosed herein.

In certain embodiments, the presence of a statin response allele disclosed herein in Tables 4-22 (an allele associated with increased response to statin treatment for reducing CVD or CHD risk) is detected and indicates that an individual has an increased risk for developing CVD, such as CHD (e.g., MI) or stroke. In these embodiments, in which the same allele is associated with both increased risk for developing CVD and increased response to statin treatment (i.e., the same allele is both a risk and a response allele), this increased risk for developing CVD can be reduced by administering statin treatment to an individual having the allele.

The nucleic acid molecules of the invention can be inserted in an expression vector, such as to produce a variant protein in a host cell. Thus, the present invention also provides for a vector comprising a SNP-containing nucleic acid molecule, genetically-engineered host cells containing the vector, and methods for expressing a recombinant variant protein using such host cells. In another specific embodiment, the host cells, SNP-containing nucleic acid molecules, and/or variant proteins can be used as targets in a method for screening and identifying therapeutic agents or pharmaceutical compounds useful in the treatment or prevention of CVD, such as CHD (e.g., MI) or stroke.

An aspect of this invention is a method for treating or preventing CVD such as CHD or stroke (including, for example, a first occurrence and/or a recurrence of the disease, such as primary or recurrent MI), in a human subject wherein said human subject harbors a SNP, gene, transcript, and/or encoded protein identified in Tables 1 and 2, which method comprises administering to said human subject a therapeutically or prophylactically effective amount of one or more agents counteracting the effects of the disease, such as by inhibiting (or stimulating) the activity of a gene, transcript, and/or encoded protein identified in Tables 1 and 2.

Another aspect of this invention is a method for identifying an agent useful in therapeutically or prophylactically treating CVD (particularly CHD or stroke), in a human subject wherein said human subject harbors a SNP, gene, transcript, and/or encoded protein identified in Tables 1 and 2, which method comprises contacting the gene, transcript, or encoded protein with a candidate agent under conditions suitable to allow formation of a binding complex between the gene, transcript, or encoded protein and the candidate agent and detecting the formation of the binding complex, wherein the presence of the complex identifies said agent.

Another aspect of this invention is a method for treating or preventing CVD such as CHD (e.g., MI) or stroke, in a human subject, in which the method comprises:

(i) determining that said human subject harbors a SNP, gene, transcript, and/or encoded protein identified in Tables 1 and 2, and

(ii) administering to said subject a therapeutically or prophylactically effective amount of one or more agents counteracting the effects of the disease, such as statins.

Another aspect of the invention is a method for identifying a human who is likely to benefit from statin treatment, in which the method comprises detecting an allele of one or more SNPs disclosed herein in said human's nucleic acids, wherein the presence of the allele indicates that said human is likely to benefit from statin treatment.

Another aspect of the invention is a method for identifying a human who is likely to benefit from statin treatment, in which the method comprises detecting an allele of one or more SNPs that are in LD with one or more SNPs disclosed herein in said human's nucleic acids, wherein the presence of the allele of the LD SNP indicates that said human is likely to benefit from statin treatment.

Many other uses and advantages of the present invention will be apparent to those skilled in the art upon review of the detailed description of the exemplary embodiments herein. Solely for clarity of discussion, the invention is described in the sections below by way of non-limiting examples.

DESCRIPTION OF THE TEXT (ASCII) FILES SUBMITTED ELECTRONICALLY VIA EFS-WEB

The following three text (ASCII) files are submitted electronically via EFS-Web as part of the instant application:

1) File SEQLIST_CD000027ORD.txt provides the Sequence Listing. The Sequence Listing provides the transcript sequences (SEQ ID NOS: 1-51) and protein sequences (SEQ ID NOS: 52-102) as referred to in Table 1, and genomic sequences (SEQ ID NOS: 177-622) as referred to in Table 2, for each gene (or genomic region for intergenic SNPs) that contains one or more statin response-associated SNPs of the present invention. Also provided in the Sequence Listing are context sequences flanking each SNP, including both transcript-based context sequences as referred to in Table 1 (SEQ ID NOS: 103-176) and genomic-based context sequences as referred to in Table 2 (SEQ ID NOS: 623-3661). The context sequences generally provide 100 bp upstream (5′) and 100 bp downstream (3′) of each SNP, with the SNP in the middle of the context sequence, for a total of 200 bp of context sequence surrounding each SNP. File SEQLIST_CD000027ORD.txt is 63,960 KB in size, and was created on Apr. 5, 2011.

2) File TABLE1_CD000027ORD.txt provides Table 1, which is 78 KB in size and was created on Apr. 6, 2011.

3) File TABLE2_CD000027ORD.txt provides Table 2, which is 1,971 KB in size and was created on Apr. 6, 2011.

These three text files are hereby incorporated by reference pursuant to 37 CFR 1.77(b)(4).

LENGTHY TABLES The patent contains a lengthy table section. A copy of the table is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US10563263B2). An electronic copy of the table will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Description of Table 1 and Table 2 Table 1 and Table 2 (both submitted electronically via EFS-Web as part of the instant application) disclose the SNP and associated gene/transcript/protein information and sequences for the SNPs disclosed in Tables 4-22, as well as for the LD SNPs disclosed in Table 3. Table 1 is based on transcript and protein sequences, whereas Table 2 is based on genomic sequences.

For each gene, Table 1 provides a header containing gene, transcript and protein information, followed by a transcript and protein sequence identifier (SEQ ID NO), and then SNP information regarding each SNP found in that gene/transcript including the transcript context sequence. For each gene in Table 2, a header is provided that contains gene and genomic information, followed by a genomic sequence identifier (SEQ ID NO) and then SNP information regarding each SNP found in that gene, including the genomic context sequence.

Note that SNP markers may be included in both Table 1 and Table 2; Table 1 presents the SNPs relative to their transcript sequences and encoded protein sequences, whereas Table 2 presents the SNPs relative to their genomic sequences. In some instances Table 2 may also include, after the last gene sequence, genomic sequences of one or more intergenic regions, as well as SNP context sequences and other SNP information for any SNPs that lie within these intergenic regions. Additionally, in either Table 1 or 2, a “Related Interrogated SNP” may be listed following a SNP which is determined to be in LD with that interrogated SNP according to the given Power value. SNPs can be readily cross-referenced between all Tables based on their Celera hCV (or, in some instances, hDV) identification numbers and/or public rs identification numbers, and to the Sequence Listing based on their corresponding SEQ ID NOs.

The gene/transcript/protein information includes:

-   -   a gene number (1 through n, where n=the total number of genes in         the Table),     -   a gene symbol, along with an Entrez gene identification number         (Entrez Gene database, National Center for Biotechnology         Information (NCBI), National Library of Medicine (NLM), National         Institutes of Health (NIH))     -   a gene name,     -   an accession number for the transcript (e.g., RefSeq NM number,         or a Celera hCT identification number if no RefSeq NM number is         available) (Table 1 only),     -   an accession number for the protein (e.g., RefSeq NP number, or         a Celera hCP identification number if no RefSeq NP number is         available) (Table 1 only),     -   the chromosome number of the chromosome on which the gene is         located,     -   an OMIM (“Online Mendelian Inheritance in Man” database, Johns         Hopkins University/NCBI) public reference number for the gene,         and OMIM information such as alternative gene/protein name(s)         and/or symbol(s) in the OMIM entry.

Note that, due to the presence of alternative splice forms, multiple transcript/protein entries may be provided for a single gene entry in Table 1; i.e., for a single Gene Number, multiple entries may be provided in series that differ in their transcript/protein information and sequences.

Following the gene/transcript/protein information is a transcript context sequence (Table 1), or a genomic context sequence (Table 2), for each SNP within that gene.

After the last gene sequence, Table 2 may include additional genomic sequences of intergenic regions (in such instances, these sequences are identified as “Intergenic region:” followed by a numerical identification number), as well as SNP context sequences and other SNP information for any SNPs that lie within each intergenic region (such SNPs are identified as “INTERGENIC” for SNP type).

Note that the transcript, protein, and transcript-based SNP context sequences are all provided in the Sequence Listing. The transcript-based SNP context sequences are provided in both Table 1 and also in the Sequence Listing. The genomic and genomic-based SNP context sequences are provided in the Sequence Listing. The genomic-based SNP context sequences are provided in both Table 2 and in the Sequence Listing. SEQ ID NOs are indicated in Table 1 for the transcript-based context sequences (SEQ ID NOS: 103-176); SEQ ID NOs are indicated in Table 2 for the genomic-based context sequences (SEQ ID NOS: 623-3661).

The SNP information includes:

-   -   Context sequence (taken from the transcript sequence in Table 1,         the genomic sequence in Table 2) with the SNP represented by its         IUB code, including 100 bp upstream (5′) of the SNP position         plus 100 bp downstream (3′) of the SNP position (the         transcript-based SNP context sequences in Table 1 are provided         in the Sequence Listing as SEQ ID NOS: 103-176; the         genomic-based SNP context sequences in Table 2 are provided in         the Sequence Listing as SEQ ID NOS: 623-3661).     -   Celera hCV internal identification number for the SNP (in some         instances, an “hDV” number is given instead of an “hCV” number).     -   The corresponding public identification number for the SNP, the         rs number.     -   “SNP Chromosome Position” indicates the nucleotide position of         the SNP along the entire sequence of the chromosome as provided         in NCBI Genome Build 36.     -   SNP position (nucleotide position of the SNP within the given         transcript sequence (Table 1) or within the given genomic         sequence (Table 2)).     -   “Related Interrogated SNP” is the interrogated SNP with which         the listed SNP is in LD at the given value of Power.     -   SNP source (may include any combination of one or more of the         following five codes, depending on which internal sequencing         projects and/or public databases the SNP has been observed in:         “Applera”=SNP observed during the re-sequencing of genes and         regulatory regions of 39 individuals, “Celera”=SNP observed         during shotgun sequencing and assembly of the Celera human         genome sequence, “Celera Diagnostics”=SNP observed during         re-sequencing of nucleic acid samples from individuals who have         a disease, “dbSNP”=SNP observed in the dbSNP public database,         “HGBASE”=SNP observed in the HGBASE public database, “HGMD”=SNP         observed in the Human Gene Mutation Database (HGMD) public         database, “HapMap”=SNP observed in the International HapMap         Project public database, “CSNP”=SNP observed in an internal         Applied Biosystems (Foster City, Calif.) database of coding SNPS         (cSNPs).

Note that multiple “Applera” source entries for a single SNP indicate that the same SNP was covered by multiple overlapping amplification products and the re-sequencing results (e.g., observed allele counts) from each of these amplification products is being provided.

-   -   Population/allele/allele count information in the format of         [population1(first_allele,count|second_allele,count)population2(first_allele,count|second_allele,coun t)         total (first_allele,total count|second_allele,total count)]. The         information in this field includes populations/ethnic groups in         which particular SNP alleles have been observed         (“cau”=Caucasian, “his”=Hispanic, “chn”=Chinese, and         “afr”=African-American, “jpn”=Japanese, “ind”=Indian,         “mex”=Mexican, “ain”=“American Indian, “cra”=Celera donor,         “no_pop”=no population information available), identified SNP         alleles, and observed allele counts (within each population         group and total allele counts), where available [“−” in the         allele field represents a deletion allele of an         insertion/deletion (“indel”) polymorphism (in which case the         corresponding insertion allele, which may be comprised of one or         more nucleotides, is indicated in the allele field on the         opposite side of the “|”); “-” in the count field indicates that         allele count information is not available]. For certain SNPs         from the public dbSNP database, population/ethnic information is         indicated as follows (this population information is publicly         available in dbSNP): “HISP1”=human individual DNA (anonymized         samples) from 23 individuals of self-described HISPANIC         heritage; “PAC 1”=human individual DNA (anonymized samples) from         24 individuals of self-described PACIFIC RIM heritage; “CAUC         1”=human individual DNA (anonymized samples) from 31 individuals         of self-described CAUCASIAN heritage; “AFR1”=human individual         DNA (anonymized samples) from 24 individuals of self-described         AFRICAN/AFRICAN AMERICAN heritage; “P1”=human individual DNA         (anonymized samples) from 102 individuals of self-described         heritage; “PA130299515”; “SC_12_A”=SANGER 12 DNAs of Asian         origin from Corielle cell repositories, 6 of which are male and         6 female; “SC_12_C”=SANGER 12 DNAs of Caucasian origin from         Corielle cell repositories from the CEPH/UTAH library, six male         and six female; “SC_12 AA”=SANGER 12 DNAs of African-American         origin from Corielle cell repositories 6 of which are male and 6         female; “SC_95_C”=SANGER 95 DNAs of Caucasian origin from         Corielle cell repositories from the CEPH/UTAH library; and         “SC_12_CA”=Caucasians—12 DNAs from Corielle cell repositories         that are from the CEPH/UTAH library, six male and six female.

Note that for SNPs of “Applera” SNP source, genes/regulatory regions of 39 individuals (20 Caucasians and 19 African Americans) were re-sequenced and, since each SNP position is represented by two chromosomes in each individual (with the exception of SNPs on X and Y chromosomes in males, for which each SNP position is represented by a single chromosome), up to 78 chromosomes were genotyped for each SNP position. Thus, the sum of the African-American (“afr”) allele counts is up to 38, the sum of the Caucasian allele counts (“cau”) is up to 40, and the total sum of all allele counts is up to 78.

Note that semicolons separate population/allele/count information corresponding to each indicated SNP source; i.e., if four SNP sources are indicated, such as “Celera,” “dbSNP,” “HGBASE,” and “HGMD,” then population/allele/count information is provided in four groups which are separated by semicolons and listed in the same order as the listing of SNP sources, with each population/allele/count information group corresponding to the respective SNP source based on order; thus, in this example, the first population/allele/count information group would correspond to the first listed SNP source (Celera) and the third population/allele/count information group separated by semicolons would correspond to the third listed SNP source (HGBASE); if population/allele/count information is not available for any particular SNP source, then a pair of semicolons is still inserted as a place-holder in order to maintain correspondence between the list of SNP sources and the corresponding listing of population/allele/count information.

-   -   SNP type (e.g., location within gene/transcript and/or predicted         functional effect) [“MIS-SENSE MUTATION”=SNP causes a change in         the encoded amino acid (i.e., a non-synonymous coding SNP);         “SILENT MUTATION”=SNP does not cause a change in the encoded         amino acid (i.e., a synonymous coding SNP); “STOP CODON         MUTATION”=SNP is located in a stop codon; “NONSENSE         MUTATION”=SNP creates or destroys a stop codon; “UTR 5”=SNP is         located in a 5′ UTR of a transcript; “UTR 3”=SNP is located in a         3′ UTR of a transcript; “PUTATIVE UTR 5”=SNP is located in a         putative 5′ UTR; “PUTATIVE UTR 3”=SNP is located in a putative         3′ UTR; “DONOR SPLICE SITE”=SNP is located in a donor splice         site (5′ intron boundary); “ACCEPTOR SPLICE SITE”=SNP is located         in an acceptor splice site (3′ intron boundary); “CODING         REGION”=SNP is located in a protein-coding region of the         transcript; “EXON”=SNP is located in an exon; “INTRON”=SNP is         located in an intron; “hmCS”=SNP is located in a human-mouse         conserved segment; “TFBS”=SNP is located in a transcription         factor binding site; “UNKNOWN”=SNP type is not defined;         “INTERGENIC”=SNP is intergenic, i.e., outside of any gene         boundary].     -   Protein coding information (Table 1 only), where relevant, in         the format of [protein SEQ ID NO, amino acid position, (amino         acid-1, codon1) (amino acid-2, codon2)]. The information in this         field includes SEQ ID NO of the encoded protein sequence,         position of the amino acid residue within the protein identified         by the SEQ ID NO that is encoded by the codon containing the         SNP, amino acids (represented by one-letter amino acid codes)         that are encoded by the alternative SNP alleles (in the case of         stop codons, “X” is used for the one-letter amino acid code),         and alternative codons containing the alternative SNP         nucleotides which encode the amino acid residues (thus, for         example, for missense mutation-type SNPs, at least two different         amino acids and at least two different codons are generally         indicated; for silent mutation-type SNPs, one amino acid and at         least two different codons are generally indicated, etc.). In         instances where the SNP is located outside of a protein-coding         region (e.g., in a UTR region), “None” is indicated following         the protein SEQ ID NO.

Description of Table 3

Table 3 provides a list of linkage disequilibrium (LD) SNPs that are related to and derived from certain interrogated SNPs. The interrogated SNPs, which are those SNPs provided in Tables 4-22, are statistically significantly associated with, for example, response to statin treatment for reducing CVD/CHD risk, as described and shown herein. The LD SNPs provided in Table 3 all have an r² value at or above 0.9 (which was set as the Threshold r² value), and are provided as examples of SNPs which can also be used as markers for, for example, response to statin treatment for reducing risk of CVD (especially CHD, such as MI and other coronary events, as well as cerebrovascular events such as stroke) based on their being in high LD with an interrogated statin response-associated SNP.

In Table 3, the columns labeled “Interrogated SNP” presents each interrogated SNP as identified by its unique hCV and rs identification number. The columns labeled “LD SNP” presents the hCV and rs numbers of the LD SNPs that are derived from their corresponding interrogated SNPs. The column labeled “Threshold r²” presents the minimum value of r² that an LD SNP must meet in reference to an interrogated SNP in order to be included in Table 3 (the Threshold r² value is set at 0.9 for all SNPs in Table 3). The column labeled “r²” presents the actual r² value of the LD SNP in reference to the interrogated SNP to which it is related (since the Threshold r² value is set at 0.9, all SNPs in Table 3 will have an r² value at or above 0.9). The criteria for selecting the LD SNPs provided in Table 3 are further described in Example 4 below.

Sequences, SNP information, and associated gene/transcript/protein information for each of the LD SNPs listed in Table 3 is provided in Tables 1-2.

Description of Tables 4-22

Tables 4-22 provide the results of analyses for SNPs disclosed in Tables 1 and 2 (SNPs can be cross-referenced between all the tables herein based on their hCV and/or rs identification numbers). The results shown in Tables 4-22 provide support for the association of these SNPs with, for example, response to statin treatment for reducing the risk of CVD, particularly CHD (e.g., MI) and stroke.

Tables 4-8

The analyses in Tables 4-8 are further described in Example 1 below.

Cohort and case-only study designs were used to identify SNPs associated with response to statin treatment in sample sets from the CARE, WOSCOPS, and PROVE-IT trials (these sample sets, with corresponding references, are described in Example 1 below). Specifically, analyses were carried out using the entire cohorts (individuals with and without incident CHD or CVD events) or cases only (only individuals with an incident CHD or CVD event) from these three sample sets (individually, as well as in combined meta-analyses) to identify SNPs associated with a reduction in the risk of CHD or CVD (CVD includes CHD and stroke) in response to statin treatment, and the results of these analyses are provided in Table 4-7 (Table 8 provides the degree of LD (r²) between pairs of SNPs listed in Tables 5 and 7).

Tables 4-7 provides SNPs that had a synergy index (odds ratio) with P value lower than 10⁻⁴ in a meta-analysis of CARE and WOSCOPS combined (Table 4-5) or in a meta-analysis of CARE, WOSCOPS, and PROVE-IT combined (Table 6-7), in any genetic model (dominant, recessive, or additive) in either the CHD or CVD endpoint (the CHD or CVD endpoint is indicated in the last column, labeled “Endpoint”, of Tables 4-7, and the genetic model is indicated in the next to last column, labeled “Model”, of Tables 4-7). For each analysis, Tables 4-7 indicate whether the data comes from case-only analysis (“CaseOnly” in the “Source” column) or from analysis of the entire cohort (“cohort” in the “Source” column). Whenever cohort data was available, it was used in the meta-analysis.

Tables 4-5 provide meta-analyses of CARE and WOSCOPS combined (2^(nd) section of each table) for two endpoints (CHD and CVD) and three genetic models (dominant, recessive, and additive), as well as logistic regression analyses of CARE (3^(rd) section of each table) and WOSCOPS (4^(th) section of each table) individually.

Tables 6-7 provide meta-analyses of CARE, WOSCOPS, and PROVE-IT combined (2^(nd) section of each table) for two endpoints (CHD and CVD) and three genetic models (dominant, recessive, and additive), as well as logistic regression analyses of CARE (3^(rd) section of each table), WOSCOPS (4^(th) section of each table), and PROVE-IT (5^(th) section of each table) individually. For PROVE-IT, there was only one endpoint (the composite primary endpoint of the original PROVE-IT study, which includes some stroke cases), and this endpoint was used in meta-analysis of both CHD and CVD.

Tables 5 and 7 provide analyses of certain LD SNPs in CARE and WOSCOPS (Table 5) and in CARE, WOSCOPS, and PROVE-IT (Table 7). For some SNPs, case-only data was available for a first SNP while cohort data was available for a SNP in LD with the first SNP (LD SNP), which occurred when a working kPCR assay could not be made for the first SNP. For these SNPs, the data for case-only analysis and the available data for the cohort is reported. The meta-analysis was performed using the cohort data when available. These SNPs are listed in Tables 5 and 7, with the two SNPs in LD listed one below the other, and the degree of LD between each of these pairs of SNPs is provided in Table 8.

Notations in Tables 4-7 are as follows:

In Tables 4-7, “allele A1” may be interchangeably referred to as the “non-reference allele” (“non-ref”), and “allele A2” may be interchangeably referred to as the “reference allele” (“ref”). The OR's that are indicated in Tables 4-7 correspond to the indicated “non-reference allele” (“allele A1”). Thus, if OR<1, the “non-reference allele” (“allele A1”) is associated with reduction of CVD/CHD risk by statin treatment, whereas if OR>1, the other alternative allele at the SNP (the “reference allele” or “allele A2”) is associated with reduction of CVD/CHD risk by statin treatment.

The counts are indicated in the following format: allele A1 homozygotes/heterozygotes/allele A2 homozygotes. These counts indicate the number of individuals in the pravastatin (“Prava”), placebo, or atorvastatin (“Atorva”) arms of the CARE, WOSCOPS, or PROVE-IT trials (as indicated) who have the corresponding genotypes.

In Tables 4-7, “P value” indicates the p-value, “OR” indicates the odds ratio (synergy index), “OR L95” and “OR U95” indicates the lower and upper (respectively) 95% confidence interval for the odds ratio, and “Source” indicates whether the data comes from case-only analysis (“CaseOnly”) or from analysis of the entire cohort (“cohort”).

Tables 9-18

Tables 9-18 provide additional SNPs associated with response to statin treatment for reducing CVD/CHD risk. Tables 9-18 differ from Tables 4-8 in that Tables 9-18 include SNPs analyzed by imputation as well as by genotyping, whereas all of the SNPs in Tables 4-8 were analyzed by genotyping. Imputation involves imputing the allele/genotype present at a SNP for each individual in the sample set (CARE, WOSCOPS, and PROVE-IT) rather than directly genotyping the SNP in a sample from the individual. The column labeled “Source” in each of Tables 9-18 indicates whether the data presented for each SNP was derived from imputation or from genotyping.

Specifically, analyses were carried out using the same three sample sets as in Tables 4-8 (CARE, WOSCOPS, and PROVE-IT) to identify (by both genotyping and imputation) additional SNPs beyond those provided in Tables 4-8 that are also associated with a reduction in the risk of CHD or CVD. Tables 9-18 provide results of analyses of statin response for the same two endpoints as in Tables 4-8 (CHD in Tables 9-13, and CVD in Tables 14-18) and four genetic models (dominant, recessive, additive, and genotypic 2df).

Tables 9-18 provide genotyped and imputed SNPs for which the p-value for a random effect was lower than 10⁻⁴ for either the meta-analysis of CARE and WOSCOPS combined or the meta-analysis of CARE, WOSCOPS, and PROVE-IT combined, for either the CHD or CVD endpoint, and for any genetic model (dominant, recessive, additive, or genotypic). Association interaction between statin response and either the CHD or CVD phenotype was performed.

Tables 9-13 have CHD as an endpoint, whereas Tables 14-18 have CVD as an endpoint (CVD includes CHD and stroke).

Tables 9 and 14 provide results of logistic regression analysis of the CARE sample set by direct genotyping and by imputing genotypes.

Tables 10 and 15 provide results of logistic regression analysis of the WOSCOPS sample set by direct genotyping and by imputing genotypes.

Tables 11 and 16 provide results of logistic regression analysis of the PROVE-IT sample set by direct genotyping and by imputing genotypes.

Tables 12 and 17 provide results of meta-analysis of the CARE and WOSCOPS sample sets combined by direct genotyping and by imputing genotypes.

Tables 13 and 18 provide results of meta-analysis of the CARE, WOSCOPS, and PROVE-IT sample sets combined by direct genotyping and by imputing genotypes.

Notations in Tables 9-11 and 14-16 (for the analysis of CARE, WOSCOPS, and PROVE-IT sample sets individually) are as follows:

“SOURCE” indicates whether each SNP was genotyped (“Genotyped”) or imputed (“Imputed”).

“ALLELE” indicates the allele for which the given data (such as the OR) correspond to, which is also referred to herein as allele “A1” (and the other alternative allele at each SNP, which is not shown in Tables 9-11 and 14-16, but is shown in Tables 1-2 for each SNP, is referred to as allele “A2”).

“MODEL” indicates whether the model was additive (“ADD”), recessive (“REC”), dominant (“DOM”), or genotypic 2df (“GEN”).

“NMISS” indicates the number of genotypes present in the analysis (the number of non-missing genotypes).

“OR” indicates the odds ratio (synergy index (SI)). If the odds ratio is less than one for the indicated allele (i.e., allele A1) then this indicates that this allele is associated with statin response (benefit from statin treatment), i.e., fewer CVD or CHD events (e.g., MI) were observed in individuals with this allele in the pravastatin arm of CARE or WOSCOPS or the atorvastatin arm of PROVE-IT, relative to individuals with this allele in the placebo arm of CARE or WOSCOPS or the pravastatin arm of PROVE-IT. If the odds ratio is greater than one for the indicated allele, then this indicates that the other alternative allele at the SNP (the allele which is not shown in Tables 9-11 and 14-16, but is indicated in Tables 1-2, i.e., allele A2), is associated with statin response (benefit from statin treatment).

“SE” indicates standard error of the natural log of the synergy index (the synergy index is the odds ratio, labeled “OR”).

“L95” and “U95” indicates the lower and upper (respectively) 95% confidence interval for the odds ratio.

“STAT” is the test statistic used in evaluating the significance of an association in logistic regression analysis. The statistic is equal to the natural log of the synergy index divided by its standard error and follows a Gaussian distribution under the null hypothesis that the synergy index is equal to one.

“P” indicates the p-value (corresponding to a statistical test of whether the synergy index is equal to one), and “HW_PVALUE” indicates the p-value corresponding to a statistical test of whether the distribution of genotypes among subjects in the study agrees with the distribution expected according to Hardy-Weinberg equilibrium.

“ALLELE_FREQ” indicates the allele frequency of the given allele in the analyzed sample set (CARE in Tables 9 and 14; WOSCOPS in Tables 10 and 15; or PROVE-IT in Tables 11 and 16).

“PRAVA_ALLELE_FREQ” or “ATORVA_ALLELE_FREQ” indicates the allele frequency of the given allele in the pravastatin or atorvastatin-treated arms (respectively) of the CARE, WOSCOPS, or PROVE-IT trials.

“PRAVA_A1_HZ_COUNT”, “PRAVA_HET_COUNT”, and “PRAVA_A2_HZ_COUNT” (or, in Tables 11 and 16, “ATORVA_A1_HZ_COUNT”, “ATORVA_HET_COUNT”, and “ATORVA_A2_HZ_COUNT”) indicate the number of homozygotes of the allele that is indicated in the table (allele A1), the number of heterozygotes, and the number of homozygotes of the other alternative allele (allele A2) at the SNP, respectively, in the pravastatin arm of the CARE trial (in Tables 9 and 14) or the WOSCOPS trial (in Tables 10 and 15), or in the atorvastatin arm of the PROVE-IT trial (in Tables 11 and 16, in which the column headings labeled “atorvastatin” (“atorva”) are analogous to the column headings labeled “pravastatin” (“prava”) in Tables 9-10 and 14-15).

“PLACEBO_A1_HZ_COUNT”, “PLACEBO_HET_COUNT”, and “PLACEBO_A2_HZ_COUNT” (or, in Tables 11 and 16, “PRAVA_A1_HZ_COUNT”, “PRAVA_HET_COUNT”, and “PRAVA_A2_HZ_COUNT”) indicate the number of homozygotes of the allele that is indicated in the table (allele A1), the number of heterozygotes, and the number of homozygotes of the other alternative allele (allele A2) at the SNP, respectively, in the placebo arm of the CARE trial (in Tables 9 and 14) or the WOSCOPS trial (in Tables 10 and 15), or in the pravastatin arm of the PROVE-IT trial (in Tables 11 and 16, in which the column headings labeled “pravastatin” (“prava”) are analogous to the column headings labeled “placebo” in Tables 9-10 and 14-15).

Notations in Tables 12-13 and 17-18 (for the meta-analysis of CARE and WOSCOPS combined, and CARE, WOSCOPS, and PROVE-IT combined) are as follows:

“SOURCE” indicates whether each SNP was genotyped or imputed.

“ALLELE” indicates the allele for which the given data (such as the OR) correspond to, which is also referred to herein as allele “A1” (and the other alternative allele at each SNP, which is not shown in Tables 12-13 and 17-18, but is shown in Tables 1-2 for each SNP, is referred to as allele “A2”).

“MODEL” indicates whether the model was additive, recessive, dominant, or genotypic.

“P” indicates the p-value, and “P(R)” (or “P.R.”) indicates the p-value random effect. Both of these are p-values corresponding to a statistical test of whether the combined synergy index is equal to one but use different assumptions to derive the p-value. “P” is calculated using a fixed effects model, and “P(R)” is calculated using a random effects model.

“OR” indicates the odds ratio (synergy index) calculated from a fixed effects model, and “OR(R)” (or “OR.R.”) indicates the odds ratio (synergy index) calculated from a random effects model. If the odds ratio is less than one for the indicated allele (i.e., allele A1) then this indicates that this allele is associated with statin response (benefit from statin treatment), i.e., fewer CVD or CHD events (e.g., MI) were observed in individuals with this allele in a combined meta-analysis of the pravastatin arms of CARE and WOSCOPS (Tables 12 and 17) and the atorvastatin arm of PROVE-IT (Tables 13 and 18), relative to individuals with this allele in the placebo arms of CARE and WOSCOPS (Tables 12 and 17) and the pravastatin arm of PROVE-IT (Tables 13 and 18). If the odds ratio is greater than one for the indicated allele, then this indicates that the other alternative allele at the SNP (the allele which is not shown in Tables 12-13 and 17-18, but is indicated in Tables 1-2, i.e., allele A2), is associated with statin response (benefit from statin treatment).

“Q” indicates the Cochran Q test p-value, which is a p-value corresponding to the statistical test of the homogeneity of the synergy index across studies (small p-values indicate a greater degree of heterogeneity between studies).

“I” indicates the I² heterogeneity index, which can be interpreted as the proportion of total variation in the estimates of effect that is due to heterogeneity between studies.

Table 19

The analysis in Table 19 is further described in Example 2 below.

Notations in Table 19 are similar to Tables 4-7. “P.R.” and “OR.R.” indicate the p-value and odds ratio (synergy index), respectively, calculated from a random effects model (rather than a fixed effects model).

Table 19 shows that SNP rs11556924 (hCV31283062) in the ZC3HC1 gene is associated with differential reduction of CHD risk by pravastatin therapy in both the CARE and WOSCOPS sample sets.

Tables 20-22

The analyses in Tables 20-22 are further described in Example 3 below.

The results shown in Tables 20-22 provide support for the association of these SNPs with CVD risk and/or statin response, particularly risk for stroke and/or response to statin treatment for reducing the risk of stroke (Tables 20-21) and CHD (Table 22).

Tables 20-21 provides SNPs associated with stroke risk and/or stroke statin response (reduction in stroke risk by statin treatment) in the CARE sample set. Consistent with the CARE trial, the stroke endpoint in the analysis for which the results are provided in Tables 20-21 included stroke as well as transient ischemic attack (TIA).

Table 22 provides a SNP associated with CHD statin response in the CARE sample set. Table 22 shows that SNP rs873134 in the B4GALNT3 gene is associated with response to statin treatment for reducing the risk of CHD, particularly recurrent MI. In the analysis for which the results are provided in Table 22, the endpoint was recurrent MI, and the analysis was adjusted for age, gender, hypertension, diabetes, base LDL and HDL, and whether an individual was a current smoker.

Notations in Tables 20-22 are as follows:

In Tables 20-22, certain columns are labeled “RESP”, “PLACEBO, OR “ALL”. “RESP” is for statin response as measured by comparing risk (risk for stroke, including TIA, in Tables 20-21, and risk for CHD, specifically recurrent MI, in Table 22) in the pravastatin-treated group with risk in the placebo-treated group, “PLACEBO” is the placebo-treated group, and “ALL” is the combination of the placebo-treated group and the pravastatin-treated group. “RESP” is the analysis to assess statin response in the indicated genotype group.

“MODE” indicates whether the model was additive (“ADD”), recessive (“REC”), dominant (“DOM”), or genotypic (“GEN”).

“mAF CEU” (Table 20 only) indicates the frequency of the minor allele in HapMap for Europeans.

“GENO” indicates the genotype.

“STATIN” indicates either the pravastatin-treated (“Pravastatin”) or placebo-treated (“Placebo”) groups (i.e., arms of the CARE trial).

“EVENTS” indicates the total number of events (stroke or TIA for Tables 20-21, and recurrent MI for Table 22) in individuals with the indicated genotype.

“TOTAL” indicates the total number of individuals with the indicated genotype.

“HR” indicates the hazard ratio.

“L95” and “U95” indicates the lower and upper (respectively) 95% confidence interval for the hazard ratio.

“P” indicates the p-value, “P_INT” indicates p-interaction, “P_DF2” indicates two degrees of freedom p-value, and “HW(ALL)pExact” (Table 21 only) indicates p exact for Hardy Weinberg Equilibrium for the ALL group.

Throughout Tables 4-22, “OR” refers to the odds ratio, “HR” refers to the hazard ratio, and “OR L95” or “OR U95” refers to the lower and upper (respectively) 95% confidence interval for the odds ratio or hazard ratio. With respect to drug response (e.g., response to a statin), if the OR or HR of those treated with the drug (e.g., a statin) compared with those treated with a placebo within a particular genotype (or with a particular allele) is less than one, this indicates that an individual with this particular genotype or allele would benefit from the drug (an OR or HR equal to one would indicate that the drug has no effect). In contrast, with respect to drug response, if the OR or HR is greater than one for a particular allele, then this indicates that an individual with the other alternative allele would benefit from the drug. As used herein, the term “benefit” (with respect to a preventive or therapeutic drug treatment) is defined as achieving a reduced risk for a disease that the drug is intended to treat or prevent (e.g., CVD such as CHD, particularly MI) by administering the drug treatment, compared with the risk for the disease in the absence of receiving the drug treatment (or receiving a placebo in lieu of the drug treatment) for the same genotype.

With respect to disease risk, an OR or HR that is greater than one indicates that a given allele is a risk allele (which may also be referred to as a susceptibility allele), whereas an OR or HR that is less than one indicates that a given allele is a non-risk allele (which may also be referred to as a protective allele). For a given risk allele, the other alternative allele at the SNP position (which can be derived from the information provided in Tables 1-2, for example) may be considered a non-risk allele. For a given non-risk allele, the other alternative allele at the SNP position may be considered a risk allele. Thus, with respect to disease risk, if the OR or HR for a particular allele at a SNP position is greater than one, this indicates that an individual with this particular allele has a higher risk for the disease than an individual who has the other allele at the SNP position. In contrast, if the OR or HR for a particular allele is less than one, this indicates that an individual with this particular allele has a reduced risk for the disease compared with an individual who has the other allele at the SNP position.

DETAILED DESCRIPTION OF THE INVENTION

Exemplary embodiments of the present invention provide SNPs associated with response to statin treatment, particularly for reducing the risk of CVD (especially CHD, such as MI and other coronary events, as well as cerebrovascular events such as stroke), and methods for their use. The present invention further provides nucleic acid molecules containing these SNPs, methods and reagents for the detection of the SNPs disclosed herein, uses of these SNPs for the development of detection reagents, and assays or kits that utilize such reagents. The statin response-associated SNPs disclosed herein are particularly useful for predicting, screening for, and evaluating response to statin treatment, particularly for prevention or treatment of CVD (particularly CHD, such as MI and other coronary events, as well as cerebrovascular events such as stroke) using statins, in humans. The SNPs disclosed herein are also useful for diagnosing, prognosing, screening for, and evaluating predisposition to CVD, particularly CHD (such as MI) as well as cerebrovascular events such as stroke, in humans. Furthermore, such SNPs and their encoded products are useful targets for the development of therapeutic and preventive agents.

Thus, exemplary embodiments of the present invention provide individual SNPs associated with response to statin treatments, particularly for reducing the risk of CVD (especially CHD, such as MI and other coronary events, as well as cerebrovascular events such as stroke), as well as combinations of SNPs and haplotypes, polymorphic/variant transcript sequences (SEQ ID NOS: 1-51) and genomic sequences (SEQ ID NOS: 177-622) containing SNPs, encoded amino acid sequences (SEQ ID NOS: 52-102), and both transcript-based SNP context sequences (SEQ ID NOS: 103-176) and genomic-based SNP context sequences (SEQ ID NOS: 623-3661) (transcript sequences, protein sequences, and transcript-based SNP context sequences are provided in Table 1 and the Sequence Listing; genomic sequences and genomic-based SNP context sequences are provided in Table 2 and the Sequence Listing), methods of detecting these polymorphisms in a test sample, methods of determining if an individual is likely to respond to a particular treatment such as statins (particularly for treating or preventing CVD, such as CHD or stroke), methods of determining an individual's risk for developing CVD, methods of screening for compounds useful for treating CVD, compounds identified by these screening methods, methods of using the disclosed SNPs to select a treatment/preventive strategy or therapeutic agent, and methods of treating or preventing CVD.

Exemplary embodiments of the present invention further provide methods for selecting or formulating a treatment regimen (e.g., methods for determining whether or not to administer statin treatment to an individual having CVD, or who is at risk for developing CVD in the future, or who has previously had CVD, methods for selecting a particular statin-based treatment regimen such as dosage and frequency of administration of statin, or a particular form/type of statin such as a particular pharmaceutical formulation or statin compound, methods for administering (either in addition to or instead of a statin) an alternative, non-statin-based treatment, such as niacin, fibrates, or ezetimibe (e.g., Zetia® or Ezetrol®), to individuals who are predicted to be unlikely to respond positively to statin treatment, etc.), and methods for determining the likelihood of experiencing toxicity or other undesirable side effects from statin treatment, etc. The present invention also provides methods for selecting individuals to whom a statin or other therapeutic will be administered based on the individual's genotype, and methods for selecting individuals for a clinical trial of a statin or other therapeutic agent based on the genotypes of the individuals (e.g., selecting individuals to participate in the trial who are most likely to respond positively from the statin treatment and/or excluding individuals from the trial who are unlikely to respond positively from the statin treatment based on their SNP genotype(s), or selecting individuals who are unlikely to respond positively to statins based on their SNP genotype(s) to participate in a clinical trial of another type of drug that may benefit them).

Exemplary embodiments of the present invention may include novel SNPs associated with response to statin treatment, as well as SNPs that were previously known in the art, but were not previously known to be associated with response to statin treatment. Accordingly, the present invention may provide novel compositions and methods based on novel SNPs disclosed herein, and may also provide novel methods of using known, but previously unassociated, SNPs in methods relating to, for example, methods relating to evaluating an individual's likelihood of responding to statin treatment (particularly statin treatment, including preventive treatment, of CVD, such as CHD or stroke), evaluating an individual's likelihood of having or developing CVD (particularly CHD or stroke), and predicting the likelihood of an individual experiencing a reccurrence of CVD (e.g., experiencing recurrent MI). In Tables 1 and 2, known SNPs are identified based on the public database in which they have been observed, which is indicated as one or more of the following SNP types: “dbSNP”=SNP observed in dbSNP, “HGBASE”=SNP observed in HGBASE, and “HGMD”=SNP observed in the Human Gene Mutation Database (HGMD).

Particular alleles of the SNPs disclosed herein can be associated with either an increased likelihood of responding to statin treatment (particularly for reducing the risk of CVD, such as CHD (e.g., MI) or stroke) or increased risk of developing CVD (e.g., CHD or stroke), or a decreased likelihood of responding to statin treatment or a decreased risk of developing CVD. Thus, whereas certain SNPs (or their encoded products) can be assayed to determine whether an individual possesses a SNP allele that is indicative of an increased likelihood of responding to statin treatment or an increased risk of developing CVD, other SNPs (or their encoded products) can be assayed to determine whether an individual possesses a SNP allele that is indicative of a decreased likelihood of responding to statin treatment or a decreased risk of developing CVD. Similarly, particular alleles of the SNPs disclosed herein can be associated with either an increased or decreased likelihood of having a reccurrence of CVD (e.g., recurrent MI), etc. The term “altered” may be used herein to encompass either of these two possibilities (e.g., either an increased or a decreased likelihood/risk).

SNP alleles that are associated with increased response to statin treatment for reducing CVD risk (benefit from statin treatment) may be referred to as “response” alleles, and SNP alleles that are associated with a lack of response to statin treatment may be referred to as “non-response” alleles. SNP alleles that are associated with an increased risk of having or developing CVD may be referred to as “risk” or “susceptibility” alleles, and SNP alleles that are associated with a decreased risk of having or developing CVD may be referred to as “non-risk” or “protective” alleles.

In certain embodiments, the presence of a statin response allele disclosed herein in Tables 4-22 (an allele associated with increased response to statin treatment for reducing CVD or CHD risk) is detected and indicates that an individual has an increased risk for developing CVD, such as CHD (e.g., MI) or stroke. In these embodiments, in which the same allele is associated with both increased risk for developing CVD and increased response to statin treatment (i.e., the same allele is both a risk and a response allele), this increased risk for developing CVD can be reduced by administering statin treatment to an individual having the allele.

Those skilled in the art will readily recognize that nucleic acid molecules may be double-stranded molecules and that reference to a particular site on one strand refers, as well, to the corresponding site on a complementary strand. In defining a SNP position, SNP allele, or nucleotide sequence, reference to an adenine, a thymine (uridine), a cytosine, or a guanine at a particular site on one strand of a nucleic acid molecule also defines the thymine (uridine), adenine, guanine, or cytosine (respectively) at the corresponding site on a complementary strand of the nucleic acid molecule. Thus, reference may be made to either strand in order to refer to a particular SNP position, SNP allele, or nucleotide sequence. Probes and primers, may be designed to hybridize to either strand and SNP genotyping methods disclosed herein may generally target either strand. Throughout the specification, in identifying a SNP position, reference is generally made to the protein-encoding strand, only for the purpose of convenience.

References to variant peptides, polypeptides, or proteins of the present invention include peptides, polypeptides, proteins, or fragments thereof, that contain at least one amino acid residue that differs from the corresponding amino acid sequence of the art-known peptide/polypeptide/protein (the art-known protein may be interchangeably referred to as the “wild-type,” “reference,” or “normal” protein). Such variant peptides/polypeptides/proteins can result from a codon change caused by a nonsynonymous nucleotide substitution at a protein-coding SNP position (i.e., a missense mutation) disclosed by the present invention. Variant peptides/polypeptides/proteins of the present invention can also result from a nonsense mutation (i.e., a SNP that creates a premature stop codon, a SNP that generates a read-through mutation by abolishing a stop codon), or due to any SNP disclosed by the present invention that otherwise alters the structure, function, activity, or expression of a protein, such as a SNP in a regulatory region (e.g. a promoter or enhancer) or a SNP that leads to alternative or defective splicing, such as a SNP in an intron or a SNP at an exon/intron boundary. As used herein, the terms “polypeptide,” “peptide,” and “protein” are used interchangeably.

As used herein, an “allele” may refer to a nucleotide at a SNP position (wherein at least two alternative nucleotides exist in the population at the SNP position, in accordance with the inherent definition of a SNP) or may refer to an amino acid residue that is encoded by the codon which contains the SNP position (where the alternative nucleotides that are present in the population at the SNP position form alternative codons that encode different amino acid residues). An “allele” may also be referred to herein as a “variant”. Also, an amino acid residue that is encoded by a codon containing a particular SNP may simply be referred to as being encoded by the SNP.

A phrase such as “as represented by”, “as shown by”, “as symbolized by”, or “as designated by” may be used herein to refer to a SNP within a sequence (e.g., a polynucleotide context sequence surrounding a SNP), such as in the context of “a polymorphism as represented by position 101 of SEQ ID NO: X or its complement”. Typically, the sequence surrounding a SNP may be recited when referring to a SNP, however the sequence is not intended as a structural limitation beyond the specific SNP position itself. Rather, the sequence is recited merely as a way of referring to the SNP (in this example, “SEQ ID NO: X or its complement” is recited in order to refer to the SNP located at position 101 of SEQ ID NO: X, but SEQ ID NO: X or its complement is not intended as a structural limitation beyond the specific SNP position itself). In other words, it is recognized that the context sequence of SEQ ID NO: X in this example may contain one or more polymorphic nucleotide positions outside of position 101 and therefore an exact match over the full-length of SEQ ID NO: X is irrelevant since SEQ ID NO: X is only meant to provide context for referring to the SNP at position 101 of SEQ ID NO: X. Likewise, the length of the context sequence is also irrelevant (100 nucleotides on each side of a SNP position has been arbitrarily used in the present application as the length for context sequences merely for convenience and because 201 nucleotides of total length is expected to provide sufficient uniqueness to unambiguously identify a given nucleotide sequence). Thus, since a SNP is a variation at a single nucleotide position, it is customary to refer to context sequence (e.g., SEQ ID NO: X in this example) surrounding a particular SNP position in order to uniquely identify and refer to the SNP. Alternatively, a SNP can be referred to by a unique identification number such as a public “rs” identification number or an internal “hCV” identification number, such as provided herein for each SNP (e.g., in Tables 1-2). For example, in the instant application, “rs11556924”, “hCV31283062”, and “position 101 of SEQ ID NO: 1074” all refer to the same SNP.

As used herein, the term “benefit” (with respect to a preventive or therapeutic drug treatment, such as statin treatment) is defined as achieving a reduced risk for a disease that the drug is intended to treat or prevent (e.g., CVD such as CHD (particularly MI) or stroke) by administrating the drug treatment, compared with the risk for the disease in the absence of receiving the drug treatment (or receiving a placebo in lieu of the drug treatment) for the same genotype. The term “benefit” may be used herein interchangeably with terms such as “respond positively” or “positively respond”.

As used herein, the terms “drug” and “therapeutic agent” are used interchangeably, and may include, but are not limited to, small molecule compounds, biologics (e.g., antibodies, proteins, protein fragments, fusion proteins, glycoproteins, etc.), nucleic acid agents (e.g., antisense, RNAi/siRNA, and microRNA molecules, etc.), vaccines, etc., which may be used for therapeutic and/or preventive treatment of a disease (e.g., CVD such as CHD or stroke).

Examples of statins (also known as HMG-CoA reductase inhibitors) include, but are not limited to, atorvastatin (Lipitor®), rosuvastatin (Crestor®), pravastatin (Pravachol®), simvastatin (Zocor®), fluvastatin (Lescol®), and lovastatin (Mevacor®), as well as combination therapies that include a statin such as simvastatin+ezetimibe (Vytorin®), lovastatin+niacin (Advicor®), atorvastatin+amlodipine besylate (Caduet®), and simvastatin+niacin (Simcor®).

Certain exemplary embodiments of the invention provide the following compositions and uses: (1) a reagent (such as an allele-specific probe or primer, or any other oligonucleotide or other reagent suitable for detecting a polymorphism disclosed herein, which can include detection of any allele of the polymorphism) for use as a diagnostic or predictive agent for determining statin response, particularly for reducing the risk of CVD such as CHD (e.g., MI) or stroke (and/or for determining risk for developing CVD); (2) a kit, device, array, or assay component that includes or is coupled with the reagent of (1) above for use in determining statin response, particularly for reducing the risk of CVD (and/or for determining risk for developing CVD); (3) the use of the reagent of (1) above for the manufacture of a kit, device, array, or assay component for determining statin response, particularly for reducing the risk of CVD (and/or for determining risk for CVD); and (4) the use of a polymorphism disclosed herein for the manufacture of a reagent for use as a diagnostic or predictive agent for determining statin response, particularly for reducing the risk of CVD (and/or for determining risk for developing CVD).

The various methods described herein, such as correlating the presence or absence of a polymorphism with the predicted response of an individual to a drug such as a statin, particularly for reducing the risk for CVD such as CHD (e.g., MI) or stroke (and/or correlating the presence or absence of a polymorphism with an altered (e.g., increased or decreased) risk (or no altered risk) for developing CVD), can be carried out by automated methods such as by using a computer (or other apparatus/devices such as biomedical devices, laboratory instrumentation, or other apparatus/devices having a computer processor) programmed to carry out any of the methods described herein. For example, computer software (which may be interchangeably referred to herein as a computer program) can perform the step of correlating the presence or absence of a polymorphism in an individual with an altered (e.g., increased or decreased) response (or no altered response) to statin treatment, particularly for reducing the risk for CVD such as CHD (e.g., MI) or stroke. Accordingly, certain embodiments of the invention provide a computer (or other apparatus/device) programmed to carry out any of the methods described herein.

Reports, Programmed Computers, Business Methods, and Systems

The results of a test (e.g., an individual's predicted responsiveness to statin treatment for reducing CVD risk, or an individual's risk for developing CVD, based on assaying one or more SNPs disclosed herein, and/or an individual's allele(s)/genotype at one or more SNPs disclosed herein, etc.), and/or any other information pertaining to a test, may be referred to herein as a “report”. A tangible report can optionally be generated as part of a testing process (which may be interchangeably referred to herein as “reporting”, or as “providing” a report, “producing” a report, or “generating” a report).

Examples of tangible reports may include, but are not limited to, reports in paper (such as computer-generated printouts of test results) or equivalent formats and reports stored on computer readable medium (such as a CD, USB flash drive or other removable storage device, computer hard drive, or computer network server, etc.). Reports, particularly those stored on computer readable medium, can be part of a database, which may optionally be accessible via the internet (such as a database of patient records or genetic information stored on a computer network server, which may be a “secure database” that has security features that limit access to the report, such as to allow only the patient and the patient's medical practioners to view the report while preventing other unauthorized individuals from viewing the report, for example). In addition to, or as an alternative to, generating a tangible report, reports can also be displayed on a computer screen (or the display of another electronic device or instrument).

A report can include, for example, an individual's predicted responsiveness to statin treatment (e.g., whether the individual will benefit from statin treatment by having their risk for CVD, particularly CHD (e.g., MI) or stroke, reduced), or may just include the allele(s)/genotype that an individual carries at one or more SNPs disclosed herein, which may optionally be linked to information regarding the significance of having the allele(s)/genotype at the SNP (for example, a report on computer readable medium such as a network server may include hyperlink(s) to one or more journal publications or websites that describe the medical/biological implications, such as statin response and/or CVD risk, for individuals having a certain allele/genotype at the SNP). Thus, for example, the report can include drug responsiveness, disease risk, and/or other medical/biological significance, as well as optionally also including the allele/genotype information, or the report may just include allele/genotype information without including drug responsiveness, disease risk, or other medical/biological significance (such that an individual viewing the report can use the allele/genotype information to determine the associated drug response, disease risk, or other medical/biological significance from a source outside of the report itself, such as from a medical practioner, publication, website, etc., which may optionally be linked to the report such as by a hyperlink).

A report can further be “transmitted” or “communicated” (these terms may be used herein interchangeably), such as to the individual who was tested, a medical practitioner (e.g., a doctor, nurse, clinical laboratory practitioner, genetic counselor, etc.), a healthcare organization, a clinical laboratory, and/or any other party or requester intended to view or possess the report. The act of “transmitting” or “communicating” a report can be by any means known in the art, based on the format of the report. Furthermore, “transmitting” or “communicating” a report can include delivering/sending a report (“pushing”) and/or retrieving (“pulling”) a report. For example, reports can be transmitted/communicated by various means, including being physically transferred between parties (such as for reports in paper format) such as by being physically delivered from one party to another, or by being transmitted electronically or in signal form (e.g., via e-mail or over the internet, by facsimile, and/or by any wired or wireless communication methods known in the art) such as by being retrieved from a database stored on a computer network server, etc.

In certain exemplary embodiments, the invention provides computers (or other apparatus/devices such as biomedical devices or laboratory instrumentation) programmed to carry out the methods described herein. For example, in certain embodiments, the invention provides a computer programmed to receive (i.e., as input) the identity (e.g., the allele(s) or genotype at a SNP) of one or more SNPs disclosed herein and provide (i.e., as output) the predicted drug responsiveness or disease risk (e.g., an individual's predicted statin responsiveness or risk for developing CVD) or other result based on the identity of the SNP(s). Such output (e.g., communication of disease risk, disease diagnosis or prognosis, drug responsiveness, etc.) may be, for example, in the form of a report on computer readable medium, printed in paper form, and/or displayed on a computer screen or other display.

In various exemplary embodiments, the invention further provides methods of doing business (with respect to methods of doing business, the terms “individual” and “customer” are used herein interchangeably). For example, exemplary methods of doing business can comprise assaying one or more SNPs disclosed herein and providing a report that includes, for example, a customer's predicted response to statin treatment (e.g., for reducing their risk for CVD, particularly CHD (such as MI) or stroke) or their risk for developing CVD (based on which allele(s)/genotype is present at the assayed SNP(s)) and/or that includes the allele(s)/genotype at the assayed SNP(s) which may optionally be linked to information (e.g., journal publications, websites, etc.) pertaining to disease risk or other biological/medical significance such as by means of a hyperlink (the report may be provided, for example, on a computer network server or other computer readable medium that is internet-accessible, and the report may be included in a secure database that allows the customer to access their report while preventing other unauthorized individuals from viewing the report), and optionally transmitting the report. Customers (or another party who is associated with the customer, such as the customer's doctor, for example) can request/order (e.g., purchase) the test online via the internet (or by phone, mail order, at an outlet/store, etc.), for example, and a kit can be sent/delivered (or otherwise provided) to the customer (or another party on behalf of the customer, such as the customer's doctor, for example) for collection of a biological sample from the customer (e.g., a buccal swab for collecting buccal cells), and the customer (or a party who collects the customer's biological sample) can submit their biological samples for assaying (e.g., to a laboratory or party associated with the laboratory such as a party that accepts the customer samples on behalf of the laboratory, a party for whom the laboratory is under the control of (e.g., the laboratory carries out the assays by request of the party or under a contract with the party, for example), and/or a party that receives at least a portion of the customer's payment for the test). The report (e.g., results of the assay including, for example, the customer's disease risk and/or allele(s)/genotype at the assayed SNP(s)) may be provided to the customer by, for example, the laboratory that assays the SNP(s) or a party associated with the laboratory (e.g., a party that receives at least a portion of the customer's payment for the assay, or a party that requests the laboratory to carry out the assays or that contracts with the laboratory for the assays to be carried out) or a doctor or other medical practitioner who is associated with (e.g., employed by or having a consulting or contracting arrangement with) the laboratory or with a party associated with the laboratory, or the report may be provided to a third party (e.g., a doctor, genetic counselor, hospital, etc.) which optionally provides the report to the customer. In further embodiments, the customer may be a doctor or other medical practitioner, or a hospital, laboratory, medical insurance organization, or other medical organization that requests/orders (e.g., purchases) tests for the purposes of having other individuals (e.g., their patients or customers) assayed for one or more SNPs disclosed herein and optionally obtaining a report of the assay results.

In certain exemplary methods of doing business, a kit for collecting a biological sample (e.g., a buccal swab for collecting buccal cells, or other sample collection device) is provided to a medical practitioner (e.g., a physician) which the medical practitioner uses to obtain a sample (e.g., buccal cells, saliva, blood, etc.) from a patient, the sample is then sent to a laboratory (e.g., a CLIA-certified laboratory) or other facility that tests the sample for one or more SNPs disclosed herein (e.g., to determine the genotype of one or more SNPs disclosed herein, such as to determine the patient's predicted response to statin treatment for reducing their risk for CVD, particularly CHD (such as MI) or stroke, and/or their risk for developing CVD), and the results of the test (e.g., the patient's genotype at one or more SNPs disclosed herein and/or the patient's predicted statin response or CVD risk based on their SNP genotype) are provided back to the medical practitioner (and/or directly to the patient and/or to another party such as a hospital, medical insurance company, genetic counselor, etc.) who may then provide or otherwise convey the results to the patient. The results are typically provided in the form of a report, such as described above.

In certain further exemplary methods of doing business, kits for collecting a biological sample from a customer (e.g., a buccal swab for collecting buccal cells, or other sample collection device) are provided (e.g., for sale), such as at an outlet (e.g., a drug store, pharmacy, general merchandise store, or any other desirable outlet), online via the internet, by mail order, etc., whereby customers can obtain (e.g., purchase) the kits, collect their own biological samples, and submit (e.g., send/deliver via mail) their samples to a laboratory (e.g., a CLIA-certified laboratory) or other facility which tests the samples for one or more SNPs disclosed herein (e.g., to determine the genotype of one or more SNPs disclosed herein, such as to determine the customer's predicted response to statin treatment for reducing their risk for CVD, particularly CHD (e.g., MI) or stroke, and/or their risk for developing CVD) and provides the results of the test (e.g., of the customer's genotype at one or more SNPs disclosed herein and/or the customer's statin response or CVD risk based on their SNP genotype) back to the customer and/or to a third party (e.g., a physician or other medical practitioner, hospital, medical insurance company, genetic counselor, etc.). The results are typically provided in the form of a report, such as described above. If the results of the test are provided to a third party, then this third party may optionally provide another report to the customer based on the results of the test (e.g., the result of the test from the laboratory may provide the customer's genotype at one or more SNPs disclosed herein without statin response or CVD risk information, and the third party may provide a report of the customer's statin response or CVD risk based on this genotype result).

Certain further embodiments of the invention provide a system for determining whether an individual will benefit from statin treatment (or other therapy) in reducing CVD risk (particularly risk for CHD (such as MI) or stroke), or for determining an individual's risk for developing CVD. Certain exemplary systems comprise an integrated “loop” in which an individual (or their medical practitioner) requests a determination of such individual's predicted statin response (or CVD risk, etc.), this determination is carried out by testing a sample from the individual, and then the results of this determination are provided back to the requestor. For example, in certain systems, a sample (e.g., buccal cells, saliva, blood, etc.) is obtained from an individual for testing (the sample may be obtained by the individual or, for example, by a medical practitioner), the sample is submitted to a laboratory (or other facility) for testing (e.g., determining the genotype of one or more SNPs disclosed herein), and then the results of the testing are sent to the patient (which optionally can be done by first sending the results to an intermediary, such as a medical practioner, who then provides or otherwise conveys the results to the individual and/or acts on the results), thereby forming an integrated loop system for determining an individual's predicted statin response (or CVD risk, etc.). The portions of the system in which the results are transmitted (e.g., between any of a testing facility, a medical practitioner, and/or the individual) can be carried out by way of electronic or signal transmission (e.g., by computer such as via e-mail or the internet, by providing the results on a website or computer network server which may optionally be a secure database, by phone or fax, or by any other wired or wireless transmission methods known in the art). Optionally, the system can further include a risk reduction component (i.e., a disease management system) as part of the integrated loop (for an example of a disease management system, see U.S. Pat. No. 6,770,029, “Disease management system and method including correlation assessment”). For example, the results of the test can be used to reduce the risk of the disease in the individual who was tested, such as by implementing a preventive therapy regimen (e.g., administration of a statin or other drug for reducing CVD risk), modifying the individual's diet, increasing exercise, reducing stress, and/or implementing any other physiological or behavioral modifications in the individual with the goal of reducing disease risk. For reducing CVD risk, this may include any means used in the art for improving aspects of an individual's health relevant to reducing CVD risk. Thus, in exemplary embodiments, the system is controlled by the individual and/or their medical practioner in that the individual and/or their medical practioner requests the test, receives the test results back, and (optionally) acts on the test results to reduce the individual's disease risk, such as by implementing a disease management system.

Isolated Nucleic Acid Molecules and SNP Detection Reagents & Kits

Tables 1 and 2 provide a variety of information about each SNP of the present invention that is associated with response to statin treatment, particularly for reducing an individual's risk for CVD such as CHD (e.g., MI) or stroke, including the transcript sequences (SEQ ID NOS: 1-51), genomic sequences (SEQ ID NOS: 177-622), and protein sequences (SEQ ID NOS: 52-102) of the encoded gene products (with the SNPs indicated by IUB codes in the nucleic acid sequences). In addition, Tables 1 and 2 include SNP context sequences, which generally include 100 nucleotide upstream (5′) plus 100 nucleotides downstream (3′) of each SNP position (SEQ ID NOS: 103-176 correspond to transcript-based SNP context sequences disclosed in Table 1, and SEQ ID NOS: 623-3661 correspond to genomic-based context sequences disclosed in Table 2), the alternative nucleotides (alleles) at each SNP position, and additional information about the variant where relevant, such as SNP type (coding, missense, splice site, UTR, etc.), human populations in which the SNP was observed, observed allele frequencies, information about the encoded protein, etc.

Isolated Nucleic Acid Molecules

Exemplary embodiments of the invention provide isolated nucleic acid molecules that contain one or more SNPs disclosed herein, particularly SNPs disclosed in Table 1 and/or Table 2. Isolated nucleic acid molecules containing one or more SNPs disclosed herein (such as in at least one of Tables 1 and 2) may be interchangeably referred to throughout the present text as “SNP-containing nucleic acid molecules.” Isolated nucleic acid molecules may optionally encode a full-length variant protein or fragment thereof. The isolated nucleic acid molecules of the present invention also include probes and primers (which are described in greater detail below in the section entitled “SNP Detection Reagents”), which may be used for assaying the disclosed SNPs, and isolated full-length genes, transcripts, cDNA molecules, and fragments thereof, which may be used for such purposes as expressing an encoded protein.

As used herein, an “isolated nucleic acid molecule” generally is one that contains a SNP of the present invention or one that hybridizes to such molecule such as a nucleic acid with a complementary sequence, and is separated from most other nucleic acids present in the natural source of the nucleic acid molecule. Moreover, an “isolated” nucleic acid molecule, such as a cDNA molecule containing a SNP of the present invention, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. A nucleic acid molecule can be fused to other coding or regulatory sequences and still be considered “isolated.” Nucleic acid molecules present in non-human transgenic animals, which do not naturally occur in the animal, are also considered “isolated.” For example, recombinant DNA molecules contained in a vector are considered “isolated.” Further examples of “isolated” DNA molecules include recombinant DNA molecules maintained in heterologous host cells, and purified (partially or substantially) DNA molecules in solution. Isolated RNA molecules include in vivo or in vitro RNA transcripts of the isolated SNP-containing DNA molecules of the present invention. Isolated nucleic acid molecules according to the present invention further include such molecules produced synthetically.

Generally, an isolated SNP-containing nucleic acid molecule comprises one or more SNP positions disclosed by the present invention with flanking nucleotide sequences on either side of the SNP positions. A flanking sequence can include nucleotide residues that are naturally associated with the SNP site and/or heterologous nucleotide sequences. Preferably, the flanking sequence is up to about 500, 300, 100, 60, 50, 30, 25, 20, 15, 10, 8, or 4 nucleotides (or any other length in-between) on either side of a SNP position, or as long as the full-length gene or entire protein-coding sequence (or any portion thereof such as an exon), especially if the SNP-containing nucleic acid molecule is to be used to produce a protein or protein fragment.

For full-length genes and entire protein-coding sequences, a SNP flanking sequence can be, for example, up to about 5 KB, 4 KB, 3 KB, 2 KB, 1 KB on either side of the SNP. Furthermore, in such instances the isolated nucleic acid molecule comprises exonic sequences (including protein-coding and/or non-coding exonic sequences), but may also include intronic sequences. Thus, any protein coding sequence may be either contiguous or separated by introns. The important point is that the nucleic acid is isolated from remote and unimportant flanking sequences and is of appropriate length such that it can be subjected to the specific manipulations or uses described herein such as recombinant protein expression, preparation of probes and primers for assaying the SNP position, and other uses specific to the SNP-containing nucleic acid sequences.

An isolated SNP-containing nucleic acid molecule can comprise, for example, a full-length gene or transcript, such as a gene isolated from genomic DNA (e.g., by cloning or PCR amplification), a cDNA molecule, or an mRNA transcript molecule. Polymorphic transcript sequences are referred to in Table 1 and provided in the Sequence Listing (SEQ ID NOS: 1-51), and polymorphic genomic sequences are referred to in Table 2 and provided in the Sequence Listing (SEQ ID NOS: 177-622). Furthermore, fragments of such full-length genes and transcripts that contain one or more SNPs disclosed herein are also encompassed by the present invention, and such fragments may be used, for example, to express any part of a protein, such as a particular functional domain or an antigenic epitope.

Thus, the present invention also encompasses fragments of the nucleic acid sequences as disclosed in Tables 1 and 2 (transcript sequences are referred to in Table 1 as SEQ ID NOS: 1-51, genomic sequences are referred to in Table 2 as SEQ ID NOS: 177-622, transcript-based SNP context sequences are referred to in Table 1 as SEQ ID NOS: 103-176, and genomic-based SNP context sequences are referred to in Table 2 as SEQ ID NOS: 623-3661) and their complements. The actual sequences referred to in the tables are provided in the Sequence Listing. A fragment typically comprises a contiguous nucleotide sequence at least about 8 or more nucleotides, more preferably at least about 12 or more nucleotides, and even more preferably at least about 16 or more nucleotides. Furthermore, a fragment could comprise at least about 18, 20, 22, 25, 30, 40, 50, 60, 80, 100, 150, 200, 250 or 500 nucleotides in length (or any other number in between). The length of the fragment will be based on its intended use. For example, the fragment can encode epitope-bearing regions of a variant peptide or regions of a variant peptide that differ from the normal/wild-type protein, or can be useful as a polynucleotide probe or primer. Such fragments can be isolated using the nucleotide sequences provided in Table 1 and/or Table 2 for the synthesis of a polynucleotide probe. A labeled probe can then be used, for example, to screen a cDNA library, genomic DNA library, or mRNA to isolate nucleic acid corresponding to the coding region. Further, primers can be used in amplification reactions, such as for purposes of assaying one or more SNPs sites or for cloning specific regions of a gene.

An isolated nucleic acid molecule of the present invention further encompasses a SNP-containing polynucleotide that is the product of any one of a variety of nucleic acid amplification methods, which are used to increase the copy numbers of a polynucleotide of interest in a nucleic acid sample. Such amplification methods are well known in the art, and they include but are not limited to, polymerase chain reaction (PCR) (U.S. Pat. Nos. 4,683,195 and 4,683,202; PCR Technology: Principles and Applications for DNA Amplification, ed. H. A. Erlich, Freeman Press, NY, N.Y. (1992)), ligase chain reaction (LCR) (Wu and Wallace, Genomics 4:560 (1989); Landegren et al., Science 241:1077 (1988)), strand displacement amplification (SDA) (U.S. Pat. Nos. 5,270,184 and 5,422,252), transcription-mediated amplification (TMA) (U.S. Pat. No. 5,399,491), linked linear amplification (LLA) (U.S. Pat. No. 6,027,923) and the like, and isothermal amplification methods such as nucleic acid sequence based amplification (NASBA) and self-sustained sequence replication (Guatelli et al., Proc Natl Acad Sci USA 87:1874 (1990)). Based on such methodologies, a person skilled in the art can readily design primers in any suitable regions 5′ and 3′ to a SNP disclosed herein. Such primers may be used to amplify DNA of any length so long that it contains the SNP of interest in its sequence.

As used herein, an “amplified polynucleotide” of the invention is a SNP-containing nucleic acid molecule whose amount has been increased at least two fold by any nucleic acid amplification method performed in vitro as compared to its starting amount in a test sample. In other preferred embodiments, an amplified polynucleotide is the result of at least ten fold, fifty fold, one hundred fold, one thousand fold, or even ten thousand fold increase as compared to its starting amount in a test sample. In a typical PCR amplification, a polynucleotide of interest is often amplified at least fifty thousand fold in amount over the unamplified genomic DNA, but the precise amount of amplification needed for an assay depends on the sensitivity of the subsequent detection method used.

Generally, an amplified polynucleotide is at least about 16 nucleotides in length. More typically, an amplified polynucleotide is at least about 20 nucleotides in length. In a preferred embodiment of the invention, an amplified polynucleotide is at least about 30 nucleotides in length. In a more preferred embodiment of the invention, an amplified polynucleotide is at least about 32, 40, 45, 50, or 60 nucleotides in length. In yet another preferred embodiment of the invention, an amplified polynucleotide is at least about 100, 200, 300, 400, or 500 nucleotides in length. While the total length of an amplified polynucleotide of the invention can be as long as an exon, an intron or the entire gene where the SNP of interest resides, an amplified product is typically up to about 1,000 nucleotides in length (although certain amplification methods may generate amplified products greater than 1000 nucleotides in length). More preferably, an amplified polynucleotide is not greater than about 600-700 nucleotides in length. It is understood that irrespective of the length of an amplified polynucleotide, a SNP of interest may be located anywhere along its sequence.

In a specific embodiment of the invention, the amplified product is at least about 201 nucleotides in length, comprises one of the transcript-based context sequences or the genomic-based context sequences shown in Tables 1 and 2. Such a product may have additional sequences on its 5′ end or 3′ end or both. In another embodiment, the amplified product is about 101 nucleotides in length, and it contains a SNP disclosed herein. Preferably, the SNP is located at the middle of the amplified product (e.g., at position 101 in an amplified product that is 201 nucleotides in length, or at position 51 in an amplified product that is 101 nucleotides in length), or within 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 15, or 20 nucleotides from the middle of the amplified product. However, as indicated above, the SNP of interest may be located anywhere along the length of the amplified product.

The present invention provides isolated nucleic acid molecules that comprise, consist of, or consist essentially of one or more polynucleotide sequences that contain one or more SNPs disclosed herein, complements thereof, and SNP-containing fragments thereof.

Accordingly, the present invention provides nucleic acid molecules that consist of any of the nucleotide sequences shown in Table 1 and/or Table 2 (transcript sequences are referred to in Table 1 as SEQ ID NOS: 1-51, genomic sequences are referred to in Table 2 as SEQ ID NOS: 177-622, transcript-based SNP context sequences are referred to in Table 1 as SEQ ID NOS: 103-176, and genomic-based SNP context sequences are referred to in Table 2 as SEQ ID NOS: 623-3661), or any nucleic acid molecule that encodes any of the variant proteins referred to in Table 1 (SEQ ID NOS: 52-102). The actual sequences referred to in the tables are provided in the Sequence Listing. A nucleic acid molecule consists of a nucleotide sequence when the nucleotide sequence is the complete nucleotide sequence of the nucleic acid molecule.

The present invention further provides nucleic acid molecules that consist essentially of any of the nucleotide sequences referred to in Table 1 and/or Table 2 (transcript sequences are referred to in Table 1 as SEQ ID NOS: 1-51, genomic sequences are referred to in Table 2 as SEQ ID NOS: 177-622, transcript-based SNP context sequences are referred to in Table 1 as SEQ ID NOS: 103-176, and genomic-based SNP context sequences are referred to in Table 2 as SEQ ID NOS: 623-3661), or any nucleic acid molecule that encodes any of the variant proteins referred to in Table 1 (SEQ ID NOS: 52-102). The actual sequences referred to in the tables are provided in the Sequence Listing. A nucleic acid molecule consists essentially of a nucleotide sequence when such a nucleotide sequence is present with only a few additional nucleotide residues in the final nucleic acid molecule.

The present invention further provides nucleic acid molecules that comprise any of the nucleotide sequences shown in Table 1 and/or Table 2 or a SNP-containing fragment thereof (transcript sequences are referred to in Table 1 as SEQ ID NOS: 1-51, genomic sequences are referred to in Table 2 as SEQ ID NOS: 177-622, transcript-based SNP context sequences are referred to in Table 1 as SEQ ID NOS: 103-176, and genomic-based SNP context sequences are referred to in Table 2 as SEQ ID NOS: 623-3661), or any nucleic acid molecule that encodes any of the variant proteins provided in Table 1 (SEQ ID NOS: 52-102). The actual sequences referred to in the tables are provided in the Sequence Listing. A nucleic acid molecule comprises a nucleotide sequence when the nucleotide sequence is at least part of the final nucleotide sequence of the nucleic acid molecule. In such a fashion, the nucleic acid molecule can be only the nucleotide sequence or have additional nucleotide residues, such as residues that are naturally associated with it or heterologous nucleotide sequences. Such a nucleic acid molecule can have one to a few additional nucleotides or can comprise many more additional nucleotides. A brief description of how various types of these nucleic acid molecules can be readily made and isolated is provided below, and such techniques are well known to those of ordinary skill in the art. Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, N.Y. (2000).

The isolated nucleic acid molecules can encode mature proteins plus additional amino or carboxyl-terminal amino acids or both, or amino acids interior to the mature peptide (when the mature form has more than one peptide chain, for instance). Such sequences may play a role in processing of a protein from precursor to a mature form, facilitate protein trafficking, prolong or shorten protein half-life, or facilitate manipulation of a protein for assay or production. As generally is the case in situ, the additional amino acids may be processed away from the mature protein by cellular enzymes.

Thus, the isolated nucleic acid molecules include, but are not limited to, nucleic acid molecules having a sequence encoding a peptide alone, a sequence encoding a mature peptide and additional coding sequences such as a leader or secretory sequence (e.g., a pre-pro or pro-protein sequence), a sequence encoding a mature peptide with or without additional coding sequences, plus additional non-coding sequences, for example introns and non-coding 5′ and 3′ sequences such as transcribed but untranslated sequences that play a role in, for example, transcription, mRNA processing (including splicing and polyadenylation signals), ribosome binding, and/or stability of mRNA. In addition, the nucleic acid molecules may be fused to heterologous marker sequences encoding, for example, a peptide that facilitates purification.

Isolated nucleic acid molecules can be in the form of RNA, such as mRNA, or in the form DNA, including cDNA and genomic DNA, which may be obtained, for example, by molecular cloning or produced by chemical synthetic techniques or by a combination thereof. Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, N.Y. (2000). Furthermore, isolated nucleic acid molecules, particularly SNP detection reagents such as probes and primers, can also be partially or completely in the form of one or more types of nucleic acid analogs, such as peptide nucleic acid (PNA). U.S. Pat. Nos. 5,539,082; 5,527,675; 5,623,049; and 5,714,331. The nucleic acid, especially DNA, can be double-stranded or single-stranded. Single-stranded nucleic acid can be the coding strand (sense strand) or the complementary non-coding strand (anti-sense strand). DNA, RNA, or PNA segments can be assembled, for example, from fragments of the human genome (in the case of DNA or RNA) or single nucleotides, short oligonucleotide linkers, or from a series of oligonucleotides, to provide a synthetic nucleic acid molecule. Nucleic acid molecules can be readily synthesized using the sequences provided herein as a reference; oligonucleotide and PNA oligomer synthesis techniques are well known in the art. See, e.g., Corey, “Peptide nucleic acids: expanding the scope of nucleic acid recognition,” Trends Biotechnol 15(6):224-9 (June 1997), and Hyrup et al., “Peptide nucleic acids (PNA): synthesis, properties and potential applications,” Bioorg Med Chem 4(1):5-23) (January 1996). Furthermore, large-scale automated oligonucleotide/PNA synthesis (including synthesis on an array or bead surface or other solid support) can readily be accomplished using commercially available nucleic acid synthesizers, such as the Applied Biosystems (Foster City, Calif.) 3900 High-Throughput DNA Synthesizer or Expedite 8909 Nucleic Acid Synthesis System, and the sequence information provided herein.

The present invention encompasses nucleic acid analogs that contain modified, synthetic, or non-naturally occurring nucleotides or structural elements or other alternative/modified nucleic acid chemistries known in the art. Such nucleic acid analogs are useful, for example, as detection reagents (e.g., primers/probes) for detecting one or more SNPs identified in Table 1 and/or Table 2. Furthermore, kits/systems (such as beads, arrays, etc.) that include these analogs are also encompassed by the present invention. For example, PNA oligomers that are based on the polymorphic sequences of the present invention are specifically contemplated. PNA oligomers are analogs of DNA in which the phosphate backbone is replaced with a peptide-like backbone. Lagriffoul et al., Bioorganic & Medicinal Chemistry Letters 4:1081-1082 (1994); Petersen et al., Bioorganic & Medicinal Chemistry Letters 6:793-796 (1996); Kumar et al., Organic Letters 3(9):1269-1272 (2001); WO 96/04000. PNA hybridizes to complementary RNA or DNA with higher affinity and specificity than conventional oligonucleotides and oligonucleotide analogs. The properties of PNA enable novel molecular biology and biochemistry applications unachievable with traditional oligonucleotides and peptides.

Additional examples of nucleic acid modifications that improve the binding properties and/or stability of a nucleic acid include the use of base analogs such as inosine, intercalators (U.S. Pat. No. 4,835,263) and the minor groove binders (U.S. Pat. No. 5,801,115). Thus, references herein to nucleic acid molecules, SNP-containing nucleic acid molecules, SNP detection reagents (e.g., probes and primers), oligonucleotides/polynucleotides include PNA oligomers and other nucleic acid analogs. Other examples of nucleic acid analogs and alternative/modified nucleic acid chemistries known in the art are described in Current Protocols in Nucleic Acid Chemistry, John Wiley & Sons, N.Y. (2002).

The present invention further provides nucleic acid molecules that encode fragments of the variant polypeptides disclosed herein as well as nucleic acid molecules that encode obvious variants of such variant polypeptides. Such nucleic acid molecules may be naturally occurring, such as paralogs (different locus) and orthologs (different organism), or may be constructed by recombinant DNA methods or by chemical synthesis. Non-naturally occurring variants may be made by mutagenesis techniques, including those applied to nucleic acid molecules, cells, or organisms. Accordingly, the variants can contain nucleotide substitutions, deletions, inversions and insertions (in addition to the SNPs disclosed in Tables 1 and 2). Variation can occur in either or both the coding and non-coding regions. The variations can produce conservative and/or non-conservative amino acid substitutions.

Further variants of the nucleic acid molecules disclosed in Tables 1 and 2, such as naturally occurring allelic variants (as well as orthologs and paralogs) and synthetic variants produced by mutagenesis techniques, can be identified and/or produced using methods well known in the art. Such further variants can comprise a nucleotide sequence that shares at least 70-80%, 80-85%, 85-90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity with a nucleic acid sequence disclosed in Table 1 and/or Table 2 (or a fragment thereof) and that includes a novel SNP allele disclosed in Table 1 and/or Table 2. Further, variants can comprise a nucleotide sequence that encodes a polypeptide that shares at least 70-80%, 80-85%, 85-90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity with a polypeptide sequence disclosed in Table 1 (or a fragment thereof) and that includes a novel SNP allele disclosed in Table 1 and/or Table 2. Thus, an aspect of the present invention that is specifically contemplated are isolated nucleic acid molecules that have a certain degree of sequence variation compared with the sequences shown in Tables 1-2, but that contain a novel SNP allele disclosed herein. In other words, as long as an isolated nucleic acid molecule contains a novel SNP allele disclosed herein, other portions of the nucleic acid molecule that flank the novel SNP allele can vary to some degree from the specific transcript, genomic, and context sequences referred to and shown in Tables 1 and 2, and can encode a polypeptide that varies to some degree from the specific polypeptide sequences referred to in Table 1.

To determine the percent identity of two amino acid sequences or two nucleotide sequences of two molecules that share sequence homology, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). In a preferred embodiment, at least 30%, 40%, 50%, 60%, 70%, 80%, or 90% or more of the length of a reference sequence is aligned for comparison purposes. The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position (as used herein, amino acid or nucleic acid “identity” is equivalent to amino acid or nucleic acid “homology”). The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences.

The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. Computational Molecular Biology, A. M. Lesk, ed., Oxford University Press, N.Y (1988); Biocomputing: Informatics and Genome Projects, D. W. Smith, ed., Academic Press, N.Y. (1993); Computer Analysis of Sequence Data, Part 1, A. M. Griffin and H. G. Griffin, eds., Humana Press, N.J. (1994); Sequence Analysis in Molecular Biology, G. von Heinje, ed., Academic Press, N.Y. (1987); and Sequence Analysis Primer, M. Gribskov and J. Devereux, eds., M. Stockton Press, N.Y. (1991). In a preferred embodiment, the percent identity between two amino acid sequences is determined using the Needleman and Wunsch algorithm (J Mol Biol (48):444-453 (1970)) which has been incorporated into the GAP program in the GCG software package, using either a Blossom 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6.

In yet another preferred embodiment, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6. J. Devereux et al., Nucleic Acids Res. 12(1):387 (1984). In another embodiment, the percent identity between two amino acid or nucleotide sequences is determined using the algorithm of E. Myers and W. Miller (CABIOS 4:11-17 (1989)) which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12, and a gap penalty of 4.

The nucleotide and amino acid sequences of the present invention can further be used as a “query sequence” to perform a search against sequence databases; for example, to identify other family members or related sequences. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0). Altschul et al., J Mol Biol 215:403-10 (1990). BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to the nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to the proteins of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized. Altschul et al., Nucleic Acids Res 25(17):3389-3402 (1997). When utilizing BLAST and gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used. In addition to BLAST, examples of other search and sequence comparison programs used in the art include, but are not limited to, FASTA (Pearson, Methods Mol Biol 25, 365-389 (1994)) and KERR (Dufresne et al., Nat Biotechnol 20(12): 1269-71 (December 2002)). For further information regarding bioinformatics techniques, see Current Protocols in Bioinformatics, John Wiley & Sons, Inc., N.Y.

The present invention further provides non-coding fragments of the nucleic acid molecules disclosed in Table 1 and/or Table 2. Preferred non-coding fragments include, but are not limited to, promoter sequences, enhancer sequences, intronic sequences, 5′ untranslated regions (UTRs), 3′ untranslated regions, gene modulating sequences and gene termination sequences. Such fragments are useful, for example, in controlling heterologous gene expression and in developing screens to identify gene-modulating agents.

SNP Detection Reagents

In a specific aspect of the present invention, the SNPs disclosed in Table 1 and/or Table 2, and their associated transcript sequences (referred to in Table 1 as SEQ ID NOS: 1-51), genomic sequences (referred to in Table 2 as SEQ ID NOS: 177-622), and context sequences (transcript-based context sequences are referred to in Table 1 as SEQ ID NOS: 103-176; genomic-based context sequences are provided in Table 2 as SEQ ID NOS: 623-3661), can be used for the design of SNP detection reagents. The actual sequences referred to in the tables are provided in the Sequence Listing. As used herein, a “SNP detection reagent” is a reagent that specifically detects a specific target SNP position disclosed herein, and that is preferably specific for a particular nucleotide (allele) of the target SNP position (i.e., the detection reagent preferably can differentiate between different alternative nucleotides at a target SNP position, thereby allowing the identity of the nucleotide present at the target SNP position to be determined). Typically, such detection reagent hybridizes to a target SNP-containing nucleic acid molecule by complementary base-pairing in a sequence specific manner, and discriminates the target variant sequence from other nucleic acid sequences such as an art-known form in a test sample. An example of a detection reagent is a probe that hybridizes to a target nucleic acid containing one or more of the SNPs referred to in Table 1 and/or Table 2. In a preferred embodiment, such a probe can differentiate between nucleic acids having a particular nucleotide (allele) at a target SNP position from other nucleic acids that have a different nucleotide at the same target SNP position. In addition, a detection reagent may hybridize to a specific region 5′ and/or 3′ to a SNP position, particularly a region corresponding to the context sequences referred to in Table 1 and/or Table 2 (transcript-based context sequences are referred to in Table 1 as SEQ ID NOS: 103-176; genomic-based context sequences are referred to in Table 2 as SEQ ID NOS: 623-3661). Another example of a detection reagent is a primer that acts as an initiation point of nucleotide extension along a complementary strand of a target polynucleotide. The SNP sequence information provided herein is also useful for designing primers, e.g. allele-specific primers, to amplify (e.g., using PCR) any SNP of the present invention.

In one preferred embodiment of the invention, a SNP detection reagent is an isolated or synthetic DNA or RNA polynucleotide probe or primer or PNA oligomer, or a combination of DNA, RNA and/or PNA, that hybridizes to a segment of a target nucleic acid molecule containing a SNP identified in Table 1 and/or Table 2. A detection reagent in the form of a polynucleotide may optionally contain modified base analogs, intercalators or minor groove binders. Multiple detection reagents such as probes may be, for example, affixed to a solid support (e.g., arrays or beads) or supplied in solution (e.g. probe/primer sets for enzymatic reactions such as PCR, RT-PCR, TaqMan assays, or primer-extension reactions) to form a SNP detection kit.

A probe or primer typically is a substantially purified oligonucleotide or PNA oligomer. Such oligonucleotide typically comprises a region of complementary nucleotide sequence that hybridizes under stringent conditions to at least about 8, 10, 12, 16, 18, 20, 22, 25, 30, 40, 50, 55, 60, 65, 70, 80, 90, 100, 120 (or any other number in-between) or more consecutive nucleotides in a target nucleic acid molecule. Depending on the particular assay, the consecutive nucleotides can either include the target SNP position, or be a specific region in close enough proximity 5′ and/or 3′ to the SNP position to carry out the desired assay.

Other preferred primer and probe sequences can readily be determined using the transcript sequences (SEQ ID NOS: 1-51), genomic sequences (SEQ ID NOS: 177-622), and SNP context sequences (transcript-based context sequences are referred to in Table 1 as SEQ ID NOS: 103-176; genomic-based context sequences are referred to in Table 2 as SEQ ID NOS: 623-3661) disclosed in the Sequence Listing and in Tables 1 and 2. The actual sequences referred to in the tables are provided in the Sequence Listing. It will be apparent to one of skill in the art that such primers and probes are directly useful as reagents for genotyping the SNPs of the present invention, and can be incorporated into any kit/system format.

In order to produce a probe or primer specific for a target SNP-containing sequence, the gene/transcript and/or context sequence surrounding the SNP of interest is typically examined using a computer algorithm that starts at the 5′ or at the 3′ end of the nucleotide sequence. Typical algorithms will then identify oligomers of defined length that are unique to the gene/SNP context sequence, have a GC content within a range suitable for hybridization, lack predicted secondary structure that may interfere with hybridization, and/or possess other desired characteristics or that lack other undesired characteristics.

A primer or probe of the present invention is typically at least about 8 nucleotides in length. In one embodiment of the invention, a primer or a probe is at least about 10 nucleotides in length. In a preferred embodiment, a primer or a probe is at least about 12 nucleotides in length. In a more preferred embodiment, a primer or probe is at least about 16, 17, 18, 19, 20, 21, 22, 23, 24 or 25 nucleotides in length. While the maximal length of a probe can be as long as the target sequence to be detected, depending on the type of assay in which it is employed, it is typically less than about 50, 60, 65, or 70 nucleotides in length. In the case of a primer, it is typically less than about 30 nucleotides in length. In a specific preferred embodiment of the invention, a primer or a probe is within the length of about 18 and about 28 nucleotides. However, in other embodiments, such as nucleic acid arrays and other embodiments in which probes are affixed to a substrate, the probes can be longer, such as on the order of 30-70, 75, 80, 90, 100, or more nucleotides in length (see the section below entitled “SNP Detection Kits and Systems”).

For analyzing SNPs, it may be appropriate to use oligonucleotides specific for alternative SNP alleles. Such oligonucleotides that detect single nucleotide variations in target sequences may be referred to by such terms as “allele-specific oligonucleotides,” “allele-specific probes,” or “allele-specific primers.” The design and use of allele-specific probes for analyzing polymorphisms is described in, e.g., Mutation Detection: A Practical Approach, Cotton et al., eds., Oxford University Press (1998); Saiki et al., Nature 324:163-166 (1986); Dattagupta, EP235,726; and Saiki, WO 89/11548.

While the design of each allele-specific primer or probe depends on variables such as the precise composition of the nucleotide sequences flanking a SNP position in a target nucleic acid molecule, and the length of the primer or probe, another factor in the use of primers and probes is the stringency of the condition under which the hybridization between the probe or primer and the target sequence is performed. Higher stringency conditions utilize buffers with lower ionic strength and/or a higher reaction temperature, and tend to require a more perfect match between probe/primer and a target sequence in order to form a stable duplex. If the stringency is too high, however, hybridization may not occur at all. In contrast, lower stringency conditions utilize buffers with higher ionic strength and/or a lower reaction temperature, and permit the formation of stable duplexes with more mismatched bases between a probe/primer and a target sequence. By way of example and not limitation, exemplary conditions for high stringency hybridization conditions using an allele-specific probe are as follows: prehybridization with a solution containing 5× standard saline phosphate EDTA (SSPE), 0.5% NaDodSO₄ (SDS) at 55° C., and incubating probe with target nucleic acid molecules in the same solution at the same temperature, followed by washing with a solution containing 2×SSPE, and 0.1% SDS at 55° C. or room temperature.

Moderate stringency hybridization conditions may be used for allele-specific primer extension reactions with a solution containing, e.g., about 50 mM KCl at about 46° C. Alternatively, the reaction may be carried out at an elevated temperature such as 60° C. In another embodiment, a moderately stringent hybridization condition suitable for oligonucleotide ligation assay (OLA) reactions wherein two probes are ligated if they are completely complementary to the target sequence may utilize a solution of about 100 mM KCl at a temperature of 46° C.

In a hybridization-based assay, allele-specific probes can be designed that hybridize to a segment of target DNA from one individual but do not hybridize to the corresponding segment from another individual due to the presence of different polymorphic forms (e.g., alternative SNP alleles/nucleotides) in the respective DNA segments from the two individuals. Hybridization conditions should be sufficiently stringent that there is a significant detectable difference in hybridization intensity between alleles, and preferably an essentially binary response, whereby a probe hybridizes to only one of the alleles or significantly more strongly to one allele. While a probe may be designed to hybridize to a target sequence that contains a SNP site such that the SNP site aligns anywhere along the sequence of the probe, the probe is preferably designed to hybridize to a segment of the target sequence such that the SNP site aligns with a central position of the probe (e.g., a position within the probe that is at least three nucleotides from either end of the probe). This design of probe generally achieves good discrimination in hybridization between different allelic forms.

In another embodiment, a probe or primer may be designed to hybridize to a segment of target DNA such that the SNP aligns with either the 5′ most end or the 3′ most end of the probe or primer. In a specific preferred embodiment that is particularly suitable for use in a oligonucleotide ligation assay (U.S. Pat. No. 4,988,617), the 3′ most nucleotide of the probe aligns with the SNP position in the target sequence.

Oligonucleotide probes and primers may be prepared by methods well known in the art. Chemical synthetic methods include, but are not limited to, the phosphotriester method described by Narang et al., Methods in Enzymology 68:90 (1979); the phosphodiester method described by Brown et al., Methods in Enzymology 68:109 (1979); the diethylphosphoamidate method described by Beaucage et al., Tetrahedron Letters 22:1859 (1981); and the solid support method described in U.S. Pat. No. 4,458,066.

Allele-specific probes are often used in pairs (or, less commonly, in sets of 3 or 4, such as if a SNP position is known to have 3 or 4 alleles, respectively, or to assay both strands of a nucleic acid molecule for a target SNP allele), and such pairs may be identical except for a one nucleotide mismatch that represents the allelic variants at the SNP position. Commonly, one member of a pair perfectly matches a reference form of a target sequence that has a more common SNP allele (i.e., the allele that is more frequent in the target population) and the other member of the pair perfectly matches a form of the target sequence that has a less common SNP allele (i.e., the allele that is rarer in the target population). In the case of an array, multiple pairs of probes can be immobilized on the same support for simultaneous analysis of multiple different polymorphisms.

In one type of PCR-based assay, an allele-specific primer hybridizes to a region on a target nucleic acid molecule that overlaps a SNP position and only primes amplification of an allelic form to which the primer exhibits perfect complementarity. Gibbs, Nucleic Acid Res 17:2427-2448 (1989). Typically, the primer's 3′-most nucleotide is aligned with and complementary to the SNP position of the target nucleic acid molecule. This primer is used in conjunction with a second primer that hybridizes at a distal site. Amplification proceeds from the two primers, producing a detectable product that indicates which allelic form is present in the test sample. A control is usually performed with a second pair of primers, one of which shows a single base mismatch at the polymorphic site and the other of which exhibits perfect complementarity to a distal site. The single-base mismatch prevents amplification or substantially reduces amplification efficiency, so that either no detectable product is formed or it is formed in lower amounts or at a slower pace. The method generally works most effectively when the mismatch is at the 3′-most position of the oligonucleotide (i.e., the 3′-most position of the oligonucleotide aligns with the target SNP position) because this position is most destabilizing to elongation from the primer (see, e.g., WO 93/22456). This PCR-based assay can be utilized as part of the TaqMan assay, described below.

In a specific embodiment of the invention, a primer of the invention contains a sequence substantially complementary to a segment of a target SNP-containing nucleic acid molecule except that the primer has a mismatched nucleotide in one of the three nucleotide positions at the 3′-most end of the primer, such that the mismatched nucleotide does not base pair with a particular allele at the SNP site. In a preferred embodiment, the mismatched nucleotide in the primer is the second from the last nucleotide at the 3′-most position of the primer. In a more preferred embodiment, the mismatched nucleotide in the primer is the last nucleotide at the 3′-most position of the primer.

In another embodiment of the invention, a SNP detection reagent of the invention is labeled with a fluorogenic reporter dye that emits a detectable signal. While the preferred reporter dye is a fluorescent dye, any reporter dye that can be attached to a detection reagent such as an oligonucleotide probe or primer is suitable for use in the invention. Such dyes include, but are not limited to, Acridine, AMCA, BODIPY, Cascade Blue, Cy2, Cy3, Cy5, Cy7, Dabcyl, Edans, Eosin, Erythrosin, Fluorescein, 6-Fam, Tet, Joe, Hex, Oregon Green, Rhodamine, Rhodol Green, Tamra, Rox, and Texas Red.

In yet another embodiment of the invention, the detection reagent may be further labeled with a quencher dye such as Tamra, especially when the reagent is used as a self-quenching probe such as a TaqMan (U.S. Pat. Nos. 5,210,015 and 5,538,848) or Molecular Beacon probe (U.S. Pat. Nos. 5,118,801 and 5,312,728), or other stemless or linear beacon probe (Livak et al., PCR Method Appl 4:357-362 (1995); Tyagi et al., Nature Biotechnology 14:303-308 (1996); Nazarenko et al., Nucl Acids Res 25:2516-2521 (1997); U.S. Pat. Nos. 5,866,336 and 6,117,635.

The detection reagents of the invention may also contain other labels, including but not limited to, biotin for streptavidin binding, hapten for antibody binding, and oligonucleotide for binding to another complementary oligonucleotide such as pairs of zipcodes.

The present invention also contemplates reagents that do not contain (or that are complementary to) a SNP nucleotide identified herein but that are used to assay one or more SNPs disclosed herein. For example, primers that flank, but do not hybridize directly to a target SNP position provided herein are useful in primer extension reactions in which the primers hybridize to a region adjacent to the target SNP position (i.e., within one or more nucleotides from the target SNP site). During the primer extension reaction, a primer is typically not able to extend past a target SNP site if a particular nucleotide (allele) is present at that target SNP site, and the primer extension product can be detected in order to determine which SNP allele is present at the target SNP site. For example, particular ddNTPs are typically used in the primer extension reaction to terminate primer extension once a ddNTP is incorporated into the extension product (a primer extension product which includes a ddNTP at the 3′-most end of the primer extension product, and in which the ddNTP is a nucleotide of a SNP disclosed herein, is a composition that is specifically contemplated by the present invention). Thus, reagents that bind to a nucleic acid molecule in a region adjacent to a SNP site and that are used for assaying the SNP site, even though the bound sequences do not necessarily include the SNP site itself, are also contemplated by the present invention.

SNP Detection Kits and Systems

A person skilled in the art will recognize that, based on the SNP and associated sequence information disclosed herein, detection reagents can be developed and used to assay any SNP of the present invention individually or in combination, and such detection reagents can be readily incorporated into one of the established kit or system formats which are well known in the art. The terms “kits” and “systems,” as used herein in the context of SNP detection reagents, are intended to refer to such things as combinations of multiple SNP detection reagents, or one or more SNP detection reagents in combination with one or more other types of elements or components (e.g., other types of biochemical reagents, containers, packages such as packaging intended for commercial sale, substrates to which SNP detection reagents are attached, electronic hardware components, etc.). Accordingly, the present invention further provides SNP detection kits and systems, including but not limited to, packaged probe and primer sets (e.g. TaqMan probe/primer sets), arrays/microarrays of nucleic acid molecules, and beads that contain one or more probes, primers, or other detection reagents for detecting one or more SNPs of the present invention. The kits/systems can optionally include various electronic hardware components; for example, arrays (“DNA chips”) and microfluidic systems (“lab-on-a-chip” systems) provided by various manufacturers typically comprise hardware components. Other kits/systems (e.g., probe/primer sets) may not include electronic hardware components, but may be comprised of, for example, one or more SNP detection reagents (along with, optionally, other biochemical reagents) packaged in one or more containers.

In some embodiments, a SNP detection kit typically contains one or more detection reagents and other components (e.g. a buffer, enzymes such as DNA polymerases or ligases, chain extension nucleotides such as deoxynucleotide triphosphates, and in the case of Sanger-type DNA sequencing reactions, chain terminating nucleotides, positive control sequences, negative control sequences, and the like) necessary to carry out an assay or reaction, such as amplification and/or detection of a SNP-containing nucleic acid molecule. A kit may further contain means for determining the amount of a target nucleic acid, and means for comparing the amount with a standard, and can comprise instructions for using the kit to detect the SNP-containing nucleic acid molecule of interest. In one embodiment of the present invention, kits are provided which contain the necessary reagents to carry out one or more assays to detect one or more SNPs disclosed herein. In a preferred embodiment of the present invention, SNP detection kits/systems are in the form of nucleic acid arrays, or compartmentalized kits, including microfluidic/lab-on-a-chip systems.

Exemplary kits of the invention can comprise a container containing a SNP detection reagent which detects a SNP disclosed herein, said container can optionally be enclosed in a package (e.g., a box for commercial sale), and said package can further include other containers containing any or all of the following: enzyme (e.g., polymerase or ligase, any of which can be thermostable), dNTPs and/or ddNTPs (which can optionally be detectably labeled, such as with a fluorescent label or mass tag, and such label can optionally differ between any of the dATPs, dCTPs, dGTPs, dTTPs, ddATPs, ddCTPs, ddGTPs, and/or ddTTPs, so that each of these dNTPs and/or ddNTPs can be distinguished from each other by detection of the label, and any of these dNTPs and/or ddNTPs can optionally be stored in the same container or each in separate containers), buffer, controls (e.g., positive control nucleic acid, or a negative control), reagent(s) for extracting nucleic acid from a test sample, and instructions for using the kit (such as instructions for correlating the presence or absence of a particular allele or genotype with an increased or decreased risk for disease such as CVD, or an increased or decreased likelihood of responding to a drug such as a statin). The SNP detection reagent can comprise, for example, at least one primer and/or probe, any of which can optionally be allele-specific, and any of which can optionally be detectably labeled (e.g., with a fluorescent label).

SNP detection kits/systems may contain, for example, one or more probes, or pairs of probes, that hybridize to a nucleic acid molecule at or near each target SNP position. Multiple pairs of allele-specific probes may be included in the kit/system to simultaneously assay large numbers of SNPs, at least one of which is a SNP of the present invention. In some kits/systems, the allele-specific probes are immobilized to a substrate such as an array or bead. For example, the same substrate can comprise allele-specific probes for detecting at least 1; 10; 100; 1000; 10,000; 100,000 (or any other number in-between) or substantially all of the SNPs shown in Table 1 and/or Table 2.

The terms “arrays,” “microarrays,” and “DNA chips” are used herein interchangeably to refer to an array of distinct polynucleotides affixed to a substrate, such as glass, plastic, paper, nylon or other type of membrane, filter, chip, or any other suitable solid support. The polynucleotides can be synthesized directly on the substrate, or synthesized separate from the substrate and then affixed to the substrate. In one embodiment, the microarray is prepared and used according to the methods described in Chee et al., U.S. Pat. No. 5,837,832 and PCT application WO95/11995; D. J. Lockhart et al., Nat Biotech 14:1675-1680 (1996); and M. Schena et al., Proc Natl Acad Sci 93:10614-10619 (1996), all of which are incorporated herein in their entirety by reference. In other embodiments, such arrays are produced by the methods described by Brown et al., U.S. Pat. No. 5,807,522.

Nucleic acid arrays are reviewed in the following references: Zammatteo et al., “New chips for molecular biology and diagnostics,” Biotechnol Annu Rev 8:85-101 (2002); Sosnowski et al., “Active microelectronic array system for DNA hybridization, genotyping and pharmacogenomic applications,” Psychiatr Genet 12(4):181-92 (December 2002); Heller, “DNA microarray technology: devices, systems, and applications,” Annu Rev Biomed Eng 4:129-53 (2002); Epub Mar. 22, 2002; Kolchinsky et al., “Analysis of SNPs and other genomic variations using gel-based chips,” Hum Mutat 19(4):343-60 (April 2002); and McGall et al., “High-density genechip oligonucleotide probe arrays,” Adv Biochem Eng Biotechnol 77:21-42 (2002).

Any number of probes, such as allele-specific probes, may be implemented in an array, and each probe or pair of probes can hybridize to a different SNP position. In the case of polynucleotide probes, they can be synthesized at designated areas (or synthesized separately and then affixed to designated areas) on a substrate using a light-directed chemical process. Each DNA chip can contain, for example, thousands to millions of individual synthetic polynucleotide probes arranged in a grid-like pattern and miniaturized (e.g., to the size of a dime). Preferably, probes are attached to a solid support in an ordered, addressable array.

A microarray can be composed of a large number of unique, single-stranded polynucleotides, usually either synthetic antisense polynucleotides or fragments of cDNAs, fixed to a solid support. Typical polynucleotides are preferably about 6-60 nucleotides in length, more preferably about 15-30 nucleotides in length, and most preferably about 18-25 nucleotides in length. For certain types of microarrays or other detection kits/systems, it may be preferable to use oligonucleotides that are only about 7-20 nucleotides in length. In other types of arrays, such as arrays used in conjunction with chemiluminescent detection technology, preferred probe lengths can be, for example, about 15-80 nucleotides in length, preferably about 50-70 nucleotides in length, more preferably about 55-65 nucleotides in length, and most preferably about 60 nucleotides in length. The microarray or detection kit can contain polynucleotides that cover the known 5′ or 3′ sequence of a gene/transcript or target SNP site, sequential polynucleotides that cover the full-length sequence of a gene/transcript; or unique polynucleotides selected from particular areas along the length of a target gene/transcript sequence, particularly areas corresponding to one or more SNPs disclosed in Table 1 and/or Table 2. Polynucleotides used in the microarray or detection kit can be specific to a SNP or SNPs of interest (e.g., specific to a particular SNP allele at a target SNP site, or specific to particular SNP alleles at multiple different SNP sites), or specific to a polymorphic gene/transcript or genes/transcripts of interest.

Hybridization assays based on polynucleotide arrays rely on the differences in hybridization stability of the probes to perfectly matched and mismatched target sequence variants. For SNP genotyping, it is generally preferable that stringency conditions used in hybridization assays are high enough such that nucleic acid molecules that differ from one another at as little as a single SNP position can be differentiated (e.g., typical SNP hybridization assays are designed so that hybridization will occur only if one particular nucleotide is present at a SNP position, but will not occur if an alternative nucleotide is present at that SNP position). Such high stringency conditions may be preferable when using, for example, nucleic acid arrays of allele-specific probes for SNP detection. Such high stringency conditions are described in the preceding section, and are well known to those skilled in the art and can be found in, for example, Current Protocols in Molecular Biology 6.3.1-6.3.6, John Wiley & Sons, N.Y. (1989).

In other embodiments, the arrays are used in conjunction with chemiluminescent detection technology. The following patents and patent applications, which are all hereby incorporated by reference, provide additional information pertaining to chemiluminescent detection. U.S. patent applications that describe chemiluminescent approaches for microarray detection: Ser. No. 10/620,332 and Ser. No. 10/620,333. U.S. patents that describe methods and compositions of dioxetane for performing chemiluminescent detection: U.S. Pat. Nos. 6,124,478; 6,107,024; 5,994,073; 5,981,768; 5,871,938; 5,843,681; 5,800,999 and 5,773,628. And the U.S. published application that discloses methods and compositions for microarray controls: US2002/0110828.

In one embodiment of the invention, a nucleic acid array can comprise an array of probes of about 15-25 nucleotides in length. In further embodiments, a nucleic acid array can comprise any number of probes, in which at least one probe is capable of detecting one or more SNPs disclosed in Table 1 and/or Table 2, and/or at least one probe comprises a fragment of one of the sequences selected from the group consisting of those disclosed in Table 1, Table 2, the Sequence Listing, and sequences complementary thereto, said fragment comprising at least about 8 consecutive nucleotides, preferably 10, 12, 15, 16, 18, 20, more preferably 22, 25, 30, 40, 47, 50, 55, 60, 65, 70, 80, 90, 100, or more consecutive nucleotides (or any other number in-between) and containing (or being complementary to) a novel SNP allele disclosed in Table 1 and/or Table 2. In some embodiments, the nucleotide complementary to the SNP site is within 5, 4, 3, 2, or 1 nucleotide from the center of the probe, more preferably at the center of said probe.

A polynucleotide probe can be synthesized on the surface of the substrate by using a chemical coupling procedure and an ink jet application apparatus, as described in PCT application WO95/251116 (Baldeschweiler et al.) which is incorporated herein in its entirety by reference. In another aspect, a “gridded” array analogous to a dot (or slot) blot may be used to arrange and link cDNA fragments or oligonucleotides to the surface of a substrate using a vacuum system, thermal, UV, mechanical or chemical bonding procedures. An array, such as those described above, may be produced by hand or by using available devices (slot blot or dot blot apparatus), materials (any suitable solid support), and machines (including robotic instruments), and may contain 8, 24, 96, 384, 1536, 6144 or more polynucleotides, or any other number which lends itself to the efficient use of commercially available instrumentation.

Using such arrays or other kits/systems, the present invention provides methods of identifying the SNPs disclosed herein in a test sample. Such methods typically involve incubating a test sample of nucleic acids with an array comprising one or more probes corresponding to at least one SNP position of the present invention, and assaying for binding of a nucleic acid from the test sample with one or more of the probes. Conditions for incubating a SNP detection reagent (or a kit/system that employs one or more such SNP detection reagents) with a test sample vary. Incubation conditions depend on such factors as the format employed in the assay, the detection methods employed, and the type and nature of the detection reagents used in the assay. One skilled in the art will recognize that any one of the commonly available hybridization, amplification and array assay formats can readily be adapted to detect the SNPs disclosed herein.

A SNP detection kit/system of the present invention may include components that are used to prepare nucleic acids from a test sample for the subsequent amplification and/or detection of a SNP-containing nucleic acid molecule. Such sample preparation components can be used to produce nucleic acid extracts (including DNA and/or RNA), proteins or membrane extracts from any bodily fluids (such as blood, serum, plasma, urine, saliva, phlegm, gastric juices, semen, tears, sweat, etc.), skin, hair, cells (especially nucleated cells) such as buccal cells (e.g., as obtained by buccal swabs), biopsies, or tissue specimens. The test samples used in the above-described methods will vary based on such factors as the assay format, nature of the detection method, and the specific tissues, cells or extracts used as the test sample to be assayed. Methods of preparing nucleic acids, proteins, and cell extracts are well known in the art and can be readily adapted to obtain a sample that is compatible with the system utilized. Automated sample preparation systems for extracting nucleic acids from a test sample are commercially available, and examples are Qiagen's BioRobot 9600, Applied Biosystems' PRISM™ 6700 sample preparation system, and Roche Molecular Systems' COBAS AmpliPrep System.

Another form of kit contemplated by the present invention is a compartmentalized kit. A compartmentalized kit includes any kit in which reagents are contained in separate containers. Such containers include, for example, small glass containers, plastic containers, strips of plastic, glass or paper, or arraying material such as silica. Such containers allow one to efficiently transfer reagents from one compartment to another compartment such that the test samples and reagents are not cross-contaminated, or from one container to another vessel not included in the kit, and the agents or solutions of each container can be added in a quantitative fashion from one compartment to another or to another vessel. Such containers may include, for example, one or more containers which will accept the test sample, one or more containers which contain at least one probe or other SNP detection reagent for detecting one or more SNPs of the present invention, one or more containers which contain wash reagents (such as phosphate buffered saline, Tris-buffers, etc.), and one or more containers which contain the reagents used to reveal the presence of the bound probe or other SNP detection reagents. The kit can optionally further comprise compartments and/or reagents for, for example, nucleic acid amplification or other enzymatic reactions such as primer extension reactions, hybridization, ligation, electrophoresis (preferably capillary electrophoresis), mass spectrometry, and/or laser-induced fluorescent detection. The kit may also include instructions for using the kit. Exemplary compartmentalized kits include microfluidic devices known in the art. See, e.g., Weigl et al., “Lab-on-a-chip for drug development,” Adv Drug Deliv Rev 55(3):349-77 (February 2003). In such microfluidic devices, the containers may be referred to as, for example, microfluidic “compartments,” “chambers,” or “channels.”

Microfluidic devices, which may also be referred to as “lab-on-a-chip” systems, biomedical micro-electro-mechanical systems (bioMEMs), or multicomponent integrated systems, are exemplary kits/systems of the present invention for analyzing SNPs. Such systems miniaturize and compartmentalize processes such as probe/target hybridization, nucleic acid amplification, and capillary electrophoresis reactions in a single functional device. Such microfluidic devices typically utilize detection reagents in at least one aspect of the system, and such detection reagents may be used to detect one or more SNPs of the present invention. One example of a microfluidic system is disclosed in U.S. Pat. No. 5,589,136, which describes the integration of PCR amplification and capillary electrophoresis in chips. Exemplary microfluidic systems comprise a pattern of microchannels designed onto a glass, silicon, quartz, or plastic wafer included on a microchip. The movements of the samples may be controlled by electric, electroosmotic or hydrostatic forces applied across different areas of the microchip to create functional microscopic valves and pumps with no moving parts. Varying the voltage can be used as a means to control the liquid flow at intersections between the micro-machined channels and to change the liquid flow rate for pumping across different sections of the microchip. See, for example, U.S. Pat. No. 6,153,073, Dubrow et al., and U.S. Pat. No. 6,156,181, Parce et al.

For genotyping SNPs, an exemplary microfluidic system may integrate, for example, nucleic acid amplification, primer extension, capillary electrophoresis, and a detection method such as laser induced fluorescence detection. In a first step of an exemplary process for using such an exemplary system, nucleic acid samples are amplified, preferably by PCR. Then, the amplification products are subjected to automated primer extension reactions using ddNTPs (specific fluorescence for each ddNTP) and the appropriate oligonucleotide primers to carry out primer extension reactions which hybridize just upstream of the targeted SNP. Once the extension at the 3′ end is completed, the primers are separated from the unincorporated fluorescent ddNTPs by capillary electrophoresis. The separation medium used in capillary electrophoresis can be, for example, polyacrylamide, polyethyleneglycol or dextran. The incorporated ddNTPs in the single nucleotide primer extension products are identified by laser-induced fluorescence detection. Such an exemplary microchip can be used to process, for example, at least 96 to 384 samples, or more, in parallel.

Uses of Nucleic Acid Molecules

The nucleic acid molecules of the present invention have a variety of uses, particularly for predicting whether an individual will benefit from statin treatment by reducing their risk for CVD (particularly CHD, such as MI) in response to the statin treatment, as well as for the diagnosis, prognosis, treatment, and prevention of CVD (particularly CHD, such as MI). For example, the nucleic acid molecules of the invention are useful for determining the likelihood of an individual who currently or previously has or has had CVD (such as an individual who has previously had an MI) or who is at increased risk for developing CVD (such as an individual who has not yet had an MI but is at increased risk for having an MI in the future) of responding to treatment (or prevention) of CVD with statins (such as by reducing their risk of developing primary or recurrent CVD, such as MI, in the future), predicting the likelihood that the individual will experience toxicity or other undesirable side effects from the statin treatment, predicting an individual's risk for developing CVD (particularly the risk for CHD such as MI), etc. For example, the nucleic acid molecules are useful as hybridization probes, such as for genotyping SNPs in messenger RNA, transcript, cDNA, genomic DNA, amplified DNA or other nucleic acid molecules, and for isolating full-length cDNA and genomic clones encoding the variant peptides disclosed in Table 1 as well as their orthologs.

A probe can hybridize to any nucleotide sequence along the entire length of a nucleic acid molecule referred to in Table 1 and/or Table 2. Preferably, a probe of the present invention hybridizes to a region of a target sequence that encompasses a SNP position indicated in Table 1 and/or Table 2. More preferably, a probe hybridizes to a SNP-containing target sequence in a sequence-specific manner such that it distinguishes the target sequence from other nucleotide sequences which vary from the target sequence only by which nucleotide is present at the SNP site. Such a probe is particularly useful for detecting the presence of a SNP-containing nucleic acid in a test sample, or for determining which nucleotide (allele) is present at a particular SNP site (i.e., genotyping the SNP site).

A nucleic acid hybridization probe may be used for determining the presence, level, form, and/or distribution of nucleic acid expression. The nucleic acid whose level is determined can be DNA or RNA. Accordingly, probes specific for the SNPs described herein can be used to assess the presence, expression and/or gene copy number in a given cell, tissue, or organism. These uses are relevant for diagnosis of disorders involving an increase or decrease in gene expression relative to normal levels. In vitro techniques for detection of mRNA include, for example, Northern blot hybridizations and in situ hybridizations. In vitro techniques for detecting DNA include Southern blot hybridizations and in situ hybridizations. Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, N.Y. (2000).

Probes can be used as part of a diagnostic test kit for identifying cells or tissues in which a variant protein is expressed, such as by measuring the level of a variant protein-encoding nucleic acid (e.g., mRNA) in a sample of cells from a subject or determining if a polynucleotide contains a SNP of interest.

Thus, the nucleic acid molecules of the invention can be used as hybridization probes to detect the SNPs disclosed herein, thereby determining the likelihood that an individual will respond positively to statin treatment for reducing the risk of CVD (particularly CHD such as MI), or whether an individual with the polymorphism(s) is at risk for developing CVD (or has already developed early stage CVD). Detection of a SNP associated with a disease phenotype provides a diagnostic tool for an active disease and/or genetic predisposition to the disease.

Furthermore, the nucleic acid molecules of the invention are therefore useful for detecting a gene (gene information is disclosed in Table 2, for example) which contains a SNP disclosed herein and/or products of such genes, such as expressed mRNA transcript molecules (transcript information is disclosed in Table 1, for example), and are thus useful for detecting gene expression. The nucleic acid molecules can optionally be implemented in, for example, an array or kit format for use in detecting gene expression.

The nucleic acid molecules of the invention are also useful as primers to amplify any given region of a nucleic acid molecule, particularly a region containing a SNP identified in Table 1 and/or Table 2.

The nucleic acid molecules of the invention are also useful for constructing recombinant vectors (described in greater detail below). Such vectors include expression vectors that express a portion of, or all of, any of the variant peptide sequences referred to in Table 1. Vectors also include insertion vectors, used to integrate into another nucleic acid molecule sequence, such as into the cellular genome, to alter in situ expression of a gene and/or gene product. For example, an endogenous coding sequence can be replaced via homologous recombination with all or part of the coding region containing one or more specifically introduced SNPs.

The nucleic acid molecules of the invention are also useful for expressing antigenic portions of the variant proteins, particularly antigenic portions that contain a variant amino acid sequence (e.g., an amino acid substitution) caused by a SNP disclosed in Table 1 and/or Table 2.

The nucleic acid molecules of the invention are also useful for constructing vectors containing a gene regulatory region of the nucleic acid molecules of the present invention.

The nucleic acid molecules of the invention are also useful for designing ribozymes corresponding to all, or a part, of an mRNA molecule expressed from a SNP-containing nucleic acid molecule described herein.

The nucleic acid molecules of the invention are also useful for constructing host cells expressing a part, or all, of the nucleic acid molecules and variant peptides.

The nucleic acid molecules of the invention are also useful for constructing transgenic animals expressing all, or a part, of the nucleic acid molecules and variant peptides. The production of recombinant cells and transgenic animals having nucleic acid molecules which contain the SNPs disclosed in Table 1 and/or Table 2 allows, for example, effective clinical design of treatment compounds and dosage regimens.

The nucleic acid molecules of the invention are also useful in assays for drug screening to identify compounds that, for example, modulate nucleic acid expression.

The nucleic acid molecules of the invention are also useful in gene therapy in patients whose cells have aberrant gene expression. Thus, recombinant cells, which include a patient's cells that have been engineered ex vivo and returned to the patient, can be introduced into an individual where the recombinant cells produce the desired protein to treat the individual.

SNP Genotyping Methods

The process of determining which nucleotide(s) is/are present at each of one or more SNP positions (such as a SNP position disclosed in Table 1 and/or Table 2), for either or both alleles, may be referred to by such phrases as SNP genotyping, determining the “identity” of a SNP, determining the “content” of a SNP, or determining which nucleotide(s)/allele(s) is/are present at a SNP position. Thus, these terms can refer to detecting a single allele (nucleotide) at a SNP position or can encompass detecting both alleles (nucleotides) at a SNP position (such as to determine the homozygous or heterozygous state of a SNP position). Furthermore, these terms may also refer to detecting an amino acid residue encoded by a SNP (such as alternative amino acid residues that are encoded by different codons created by alternative nucleotides at a missense SNP position, for example).

The present invention provides methods of SNP genotyping, such as for use in implementing a preventive or treatment regimen for an individual based on that individual having an increased susceptibility for developing CVD (e.g., increased risk for CHD, such as MI) and/or an increased likelihood of benefiting from statin treatment for reducing the risk of CVD, in evaluating an individual's likelihood of responding to statin treatment (particularly for treating or preventing CVD), in selecting a treatment or preventive regimen (e.g., in deciding whether or not to administer statin treatment to an individual having CVD, or who is at increased risk for developing CVD, such as MI, in the future), or in formulating or selecting a particular statin-based treatment or preventive regimen such as dosage and/or frequency of administration of statin treatment or choosing which form/type of statin to be administered, such as a particular pharmaceutical composition or compound, etc.), determining the likelihood of experiencing toxicity or other undesirable side effects from statin treatment, or selecting individuals for a clinical trial of a statin (e.g., selecting individuals to participate in the trial who are most likely to respond positively from the statin treatment and/or excluding individuals from the trial who are unlikely to respond positively from the statin treatment based on their SNP genotype(s), or selecting individuals who are unlikely to respond positively to statins based on their SNP genotype(s) to participate in a clinical trial of another type of drug that may benefit them), etc. The SNP genotyping methods of the invention can also be useful for evaluating an individual's risk for developing CVD (particularly CHD, such as MI) and for predicting the likelihood that an individual who has previously had CVD will have a recurrence of CVD again in the future (e.g., recurrent MI).

Nucleic acid samples can be genotyped to determine which allele(s) is/are present at any given genetic region (e.g., SNP position) of interest by methods well known in the art. The neighboring sequence can be used to design SNP detection reagents such as oligonucleotide probes, which may optionally be implemented in a kit format. Exemplary SNP genotyping methods are described in Chen et al., “Single nucleotide polymorphism genotyping: biochemistry, protocol, cost and throughput,” Pharmacogenomics J 3(2):77-96 (2003); Kwok et al., “Detection of single nucleotide polymorphisms,” Curr Issues Mol Biol 5(2):43-60 (April 2003); Shi, “Technologies for individual genotyping: detection of genetic polymorphisms in drug targets and disease genes,” Am J Pharmacogenomics 2(3):197-205 (2002); and Kwok, “Methods for genotyping single nucleotide polymorphisms,” Annu Rev Genomics Hum Genet 2:235-58 (2001). Exemplary techniques for high-throughput SNP genotyping are described in Marnellos, “High-throughput SNP analysis for genetic association studies,” Curr Opin Drug Discov Devel 6(3):317-21 (May 2003). Common SNP genotyping methods include, but are not limited to, TaqMan assays, molecular beacon assays, nucleic acid arrays, allele-specific primer extension, allele-specific PCR, arrayed primer extension, homogeneous primer extension assays, primer extension with detection by mass spectrometry, pyrosequencing, multiplex primer extension sorted on genetic arrays, ligation with rolling circle amplification, homogeneous ligation, OLA (U.S. Pat. No. 4,988,167), multiplex ligation reaction sorted on genetic arrays, restriction-fragment length polymorphism, single base extension-tag assays, and the Invader assay. Such methods may be used in combination with detection mechanisms such as, for example, luminescence or chemiluminescence detection, fluorescence detection, time-resolved fluorescence detection, fluorescence resonance energy transfer, fluorescence polarization, mass spectrometry, and electrical detection.

Various methods for detecting polymorphisms include, but are not limited to, methods in which protection from cleavage agents is used to detect mismatched bases in RNA/RNA or RNA/DNA duplexes (Myers et al., Science 230:1242 (1985); Cotton et al., PNAS 85:4397 (1988); and Saleeba et al., Meth. Enzymol 217:286-295 (1992)), comparison of the electrophoretic mobility of variant and wild type nucleic acid molecules (Orita et al., PNAS 86:2766 (1989); Cotton et al., Mutat Res 285:125-144 (1993); and Hayashi et al., Genet Anal Tech Appl 9:73-79 (1992)), and assaying the movement of polymorphic or wild-type fragments in polyacrylamide gels containing a gradient of denaturant using denaturing gradient gel electrophoresis (DGGE) (Myers et al., Nature 313:495 (1985)). Sequence variations at specific locations can also be assessed by nuclease protection assays such as RNase and S1 protection or chemical cleavage methods.

In a preferred embodiment, SNP genotyping is performed using the TaqMan assay, which is also known as the 5′ nuclease assay (U.S. Pat. Nos. 5,210,015 and 5,538,848). The TaqMan assay detects the accumulation of a specific amplified product during PCR. The TaqMan assay utilizes an oligonucleotide probe labeled with a fluorescent reporter dye and a quencher dye. The reporter dye is excited by irradiation at an appropriate wavelength, it transfers energy to the quencher dye in the same probe via a process called fluorescence resonance energy transfer (FRET). When attached to the probe, the excited reporter dye does not emit a signal. The proximity of the quencher dye to the reporter dye in the intact probe maintains a reduced fluorescence for the reporter. The reporter dye and quencher dye may be at the 5′ most and the 3′ most ends, respectively, or vice versa. Alternatively, the reporter dye may be at the 5′ or 3′ most end while the quencher dye is attached to an internal nucleotide, or vice versa. In yet another embodiment, both the reporter and the quencher may be attached to internal nucleotides at a distance from each other such that fluorescence of the reporter is reduced.

During PCR, the 5′ nuclease activity of DNA polymerase cleaves the probe, thereby separating the reporter dye and the quencher dye and resulting in increased fluorescence of the reporter. Accumulation of PCR product is detected directly by monitoring the increase in fluorescence of the reporter dye. The DNA polymerase cleaves the probe between the reporter dye and the quencher dye only if the probe hybridizes to the target SNP-containing template which is amplified during PCR, and the probe is designed to hybridize to the target SNP site only if a particular SNP allele is present.

Preferred TaqMan primer and probe sequences can readily be determined using the SNP and associated nucleic acid sequence information provided herein. A number of computer programs, such as Primer Express (Applied Biosystems, Foster City, Calif.), can be used to rapidly obtain optimal primer/probe sets. It will be apparent to one of skill in the art that such primers and probes for detecting the SNPs of the present invention are useful in, for example, screening individuals for their likelihood of responding to statin treatment (i.e., benefiting from statin treatment), particularly individuals who have or are susceptible to CVD (particularly CHD, such as MI), or in screening for individuals who are susceptible to developing CVD. These probes and primers can be readily incorporated into a kit format. The present invention also includes modifications of the Taqman assay well known in the art such as the use of Molecular Beacon probes (U.S. Pat. Nos. 5,118,801 and 5,312,728) and other variant formats (U.S. Pat. Nos. 5,866,336 and 6,117,635).

Another preferred method for genotyping the SNPs of the present invention is the use of two oligonucleotide probes in an OLA (see, e.g., U.S. Pat. No. 4,988,617). In this method, one probe hybridizes to a segment of a target nucleic acid with its 3′ most end aligned with the SNP site. A second probe hybridizes to an adjacent segment of the target nucleic acid molecule directly 3′ to the first probe. The two juxtaposed probes hybridize to the target nucleic acid molecule, and are ligated in the presence of a linking agent such as a ligase if there is perfect complementarity between the 3′ most nucleotide of the first probe with the SNP site. If there is a mismatch, ligation would not occur. After the reaction, the ligated probes are separated from the target nucleic acid molecule, and detected as indicators of the presence of a SNP.

The following patents, patent applications, and published international patent applications, which are all hereby incorporated by reference, provide additional information pertaining to techniques for carrying out various types of OLA. The following U.S. patents describe OLA strategies for performing SNP detection: U.S. Pat. Nos. 6,027,889; 6,268,148; 5,494,810; 5,830,711 and 6,054,564. WO 97/31256 and WO 00/56927 describe OLA strategies for performing SNP detection using universal arrays, wherein a zipcode sequence can be introduced into one of the hybridization probes, and the resulting product, or amplified product, hybridized to a universal zip code array. U.S. application US01/17329 (and Ser. No. 09/584,905) describes OLA (or LDR) followed by PCR, wherein zipcodes are incorporated into OLA probes, and amplified PCR products are determined by electrophoretic or universal zipcode array readout. U.S. applications 60/427,818, 60/445,636, and 60/445,494 describe SNPlex methods and software for multiplexed SNP detection using OLA followed by PCR, wherein zipcodes are incorporated into OLA probes, and amplified PCR products are hybridized with a zipchute reagent, and the identity of the SNP determined from electrophoretic readout of the zipchute. In some embodiments, OLA is carried out prior to PCR (or another method of nucleic acid amplification). In other embodiments, PCR (or another method of nucleic acid amplification) is carried out prior to OLA.

Another method for SNP genotyping is based on mass spectrometry. Mass spectrometry takes advantage of the unique mass of each of the four nucleotides of DNA. SNPs can be unambiguously genotyped by mass spectrometry by measuring the differences in the mass of nucleic acids having alternative SNP alleles. MALDI-TOF (Matrix Assisted Laser Desorption Ionization—Time of Flight) mass spectrometry technology is preferred for extremely precise determinations of molecular mass, such as SNPs. Numerous approaches to SNP analysis have been developed based on mass spectrometry. Preferred mass spectrometry-based methods of SNP genotyping include primer extension assays, which can also be utilized in combination with other approaches, such as traditional gel-based formats and microarrays.

Typically, the primer extension assay involves designing and annealing a primer to a template PCR amplicon upstream (5′) from a target SNP position. A mix of dideoxynucleotide triphosphates (ddNTPs) and/or deoxynucleotide triphosphates (dNTPs) are added to a reaction mixture containing template (e.g., a SNP-containing nucleic acid molecule which has typically been amplified, such as by PCR), primer, and DNA polymerase. Extension of the primer terminates at the first position in the template where a nucleotide complementary to one of the ddNTPs in the mix occurs. The primer can be either immediately adjacent (i.e., the nucleotide at the 3′ end of the primer hybridizes to the nucleotide next to the target SNP site) or two or more nucleotides removed from the SNP position. If the primer is several nucleotides removed from the target SNP position, the only limitation is that the template sequence between the 3′ end of the primer and the SNP position cannot contain a nucleotide of the same type as the one to be detected, or this will cause premature termination of the extension primer. Alternatively, if all four ddNTPs alone, with no dNTPs, are added to the reaction mixture, the primer will always be extended by only one nucleotide, corresponding to the target SNP position. In this instance, primers are designed to bind one nucleotide upstream from the SNP position (i.e., the nucleotide at the 3′ end of the primer hybridizes to the nucleotide that is immediately adjacent to the target SNP site on the 5′ side of the target SNP site). Extension by only one nucleotide is preferable, as it minimizes the overall mass of the extended primer, thereby increasing the resolution of mass differences between alternative SNP nucleotides. Furthermore, mass-tagged ddNTPs can be employed in the primer extension reactions in place of unmodified ddNTPs. This increases the mass difference between primers extended with these ddNTPs, thereby providing increased sensitivity and accuracy, and is particularly useful for typing heterozygous base positions. Mass-tagging also alleviates the need for intensive sample-preparation procedures and decreases the necessary resolving power of the mass spectrometer.

The extended primers can then be purified and analyzed by MALDI-TOF mass spectrometry to determine the identity of the nucleotide present at the target SNP position. In one method of analysis, the products from the primer extension reaction are combined with light absorbing crystals that form a matrix. The matrix is then hit with an energy source such as a laser to ionize and desorb the nucleic acid molecules into the gas-phase. The ionized molecules are then ejected into a flight tube and accelerated down the tube towards a detector. The time between the ionization event, such as a laser pulse, and collision of the molecule with the detector is the time of flight of that molecule. The time of flight is precisely correlated with the mass-to-charge ratio (m/z) of the ionized molecule. Ions with smaller m/z travel down the tube faster than ions with larger m/z and therefore the lighter ions reach the detector before the heavier ions. The time-of-flight is then converted into a corresponding, and highly precise, m/z. In this manner, SNPs can be identified based on the slight differences in mass, and the corresponding time of flight differences, inherent in nucleic acid molecules having different nucleotides at a single base position. For further information regarding the use of primer extension assays in conjunction with MALDI-TOF mass spectrometry for SNP genotyping, see, e.g., Wise et al., “A standard protocol for single nucleotide primer extension in the human genome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry,” Rapid Commun Mass Spectrom 17(11):1195-202 (2003).

The following references provide further information describing mass spectrometry-based methods for SNP genotyping: Bocker, “SNP and mutation discovery using base-specific cleavage and MALDI-TOF mass spectrometry,” Bioinformatics 19 Suppl 1:144-153 (July 2003); Storm et al., “MALDI-TOF mass spectrometry-based SNP genotyping,” Methods Mol Biol 212:241-62 (2003); Jurinke et al., “The use of Mass ARRAY technology for high throughput genotyping,” Adv Biochem Eng Biotechnol 77:57-74 (2002); and Jurinke et al., “Automated genotyping using the DNA MassArray technology,” Methods Mol Biol 187:179-92 (2002).

SNPs can also be scored by direct DNA sequencing. A variety of automated sequencing procedures can be utilized (e.g. Biotechniques 19:448 (1995)), including sequencing by mass spectrometry. See, e.g., PCT International Publication No. WO 94/16101; Cohen et al., Adv Chromatogr 36:127-162 (1996); and Griffin et al., Appl Biochem Biotechnol 38:147-159 (1993). The nucleic acid sequences of the present invention enable one of ordinary skill in the art to readily design sequencing primers for such automated sequencing procedures. Commercial instrumentation, such as the Applied Biosystems 377, 3100, 3700, 3730, and 3730xl DNA Analyzers (Foster City, Calif.), is commonly used in the art for automated sequencing.

Other methods that can be used to genotype the SNPs of the present invention include single-strand conformational polymorphism (SSCP), and denaturing gradient gel electrophoresis (DGGE). Myers et al., Nature 313:495 (1985). SSCP identifies base differences by alteration in electrophoretic migration of single stranded PCR products, as described in Orita et al., Proc. Nat. Acad. Single-stranded PCR products can be generated by heating or otherwise denaturing double stranded PCR products. Single-stranded nucleic acids may refold or form secondary structures that are partially dependent on the base sequence. The different electrophoretic mobilities of single-stranded amplification products are related to base-sequence differences at SNP positions. DGGE differentiates SNP alleles based on the different sequence-dependent stabilities and melting properties inherent in polymorphic DNA and the corresponding differences in electrophoretic migration patterns in a denaturing gradient gel. PCR Technology: Principles and Applications for DNA Amplification Chapter 7, Erlich, ed., W. H. Freeman and Co, N.Y. (1992).

Sequence-specific ribozymes (U.S. Pat. No. 5,498,531) can also be used to score SNPs based on the development or loss of a ribozyme cleavage site. Perfectly matched sequences can be distinguished from mismatched sequences by nuclease cleavage digestion assays or by differences in melting temperature. If the SNP affects a restriction enzyme cleavage site, the SNP can be identified by alterations in restriction enzyme digestion patterns, and the corresponding changes in nucleic acid fragment lengths determined by gel electrophoresis.

SNP genotyping can include the steps of, for example, collecting a biological sample from a human subject (e.g., sample of tissues, cells, fluids, secretions, etc.), isolating nucleic acids (e.g., genomic DNA, mRNA or both) from the cells of the sample, contacting the nucleic acids with one or more primers which specifically hybridize to a region of the isolated nucleic acid containing a target SNP under conditions such that hybridization and amplification of the target nucleic acid region occurs, and determining the nucleotide present at the SNP position of interest, or, in some assays, detecting the presence or absence of an amplification product (assays can be designed so that hybridization and/or amplification will only occur if a particular SNP allele is present or absent). In some assays, the size of the amplification product is detected and compared to the length of a control sample; for example, deletions and insertions can be detected by a change in size of the amplified product compared to a normal genotype.

SNP genotyping is useful for numerous practical applications, as described below. Examples of such applications include, but are not limited to, SNP-disease association analysis, disease predisposition screening, disease diagnosis, disease prognosis, disease progression monitoring, determining therapeutic strategies based on an individual's genotype (“pharmacogenomics”), developing therapeutic agents based on SNP genotypes associated with a disease or likelihood of responding to a drug, stratifying patient populations for clinical trials of a therapeutic, preventive, or diagnostic agent, and predicting the likelihood that an individual will experience toxic side effects from a therapeutic agent.

Analysis of Genetic Associations between SNPs and Phenotypic Traits

SNP genotyping for disease diagnosis, disease predisposition screening, disease prognosis, determining drug responsiveness (pharmacogenomics), drug toxicity screening, and other uses described herein, typically relies on initially establishing a genetic association between one or more specific SNPs and the particular phenotypic traits of interest.

Different study designs may be used for genetic association studies. Modern Epidemiology 609-622, Lippincott, Williams & Wilkins (1998). Observational studies are most frequently carried out in which the response of the patients is not interfered with. The first type of observational study identifies a sample of persons in whom the suspected cause of the disease is present and another sample of persons in whom the suspected cause is absent, and then the frequency of development of disease in the two samples is compared. These sampled populations are called cohorts, and the study is a prospective study. The other type of observational study is case-control or a retrospective study. In typical case-control studies, samples are collected from individuals with the phenotype of interest (cases) such as certain manifestations of a disease, and from individuals without the phenotype (controls) in a population (target population) that conclusions are to be drawn from. Then the possible causes of the disease are investigated retrospectively. As the time and costs of collecting samples in case-control studies are considerably less than those for prospective studies, case-control studies are the more commonly used study design in genetic association studies, at least during the exploration and discovery stage.

Case-only studies are an alternative to case-control studies when gene-environment interaction is the association of interest (Piegorsch et al., “Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies”, Statistics in Medicine 13 (1994) pp 153-162). In a typical case-only study of gene-environment interaction, genotypes are obtained only from cases who are often selected from an existing cohort study. The association between genotypes and the environmental factor is then assessed and a significant association implies that the effect of the environmental factor on the endpoint of interest (the case definition) differs by genotype. The primary assumption underlying the test of association in case-only studies is that the environmental effect of interest is independent of genotype (e.g., allocation to statin therapy is independent of genotype) and it has been shown that the case-only design has more power than the case-control design to detect gene-environment interaction when this assumption is true in the population (Yang et al., “Sample Size Requirements in Case-Only Designs to Detect Gene-Environment Interaction”, American Journal of Epidemiology 146:9 (1997) pp 713-720). Selecting cases from a randomized clinical trial may be an ideal setting in which to perform a case-only study since genotypes will be independent of treatment by design.

In observational studies, there may be potential confounding factors that should be taken into consideration. Confounding factors are those that are associated with both the real cause(s) of the disease and the disease itself, and they include demographic information such as age, gender, ethnicity as well as environmental factors. When confounding factors are not matched in cases and controls in a study, and are not controlled properly, spurious association results can arise. If potential confounding factors are identified, they should be controlled for by analysis methods explained below.

In a genetic association study, the cause of interest to be tested is a certain allele or a SNP or a combination of alleles or a haplotype from several SNPs. Thus, tissue specimens (e.g., whole blood) from the sampled individuals may be collected and genomic DNA genotyped for the SNP(s) of interest. In addition to the phenotypic trait of interest, other information such as demographic (e.g., age, gender, ethnicity, etc.), clinical, and environmental information that may influence the outcome of the trait can be collected to further characterize and define the sample set. In many cases, these factors are known to be associated with diseases and/or SNP allele frequencies. There are likely gene-environment and/or gene-gene interactions as well. Analysis methods to address gene-environment and gene-gene interactions (for example, the effects of the presence of both susceptibility alleles at two different genes can be greater than the effects of the individual alleles at two genes combined) are discussed below.

After all the relevant phenotypic and genotypic information has been obtained, statistical analyses are carried out to determine if there is any significant correlation between the presence of an allele or a genotype with the phenotypic characteristics of an individual. Preferably, data inspection and cleaning are first performed before carrying out statistical tests for genetic association. Epidemiological and clinical data of the samples can be summarized by descriptive statistics with tables and graphs. Data validation is preferably performed to check for data completion, inconsistent entries, and outliers. Chi-squared tests and t-tests (Wilcoxon rank-sum tests if distributions are not normal) may then be used to check for significant differences between cases and controls for discrete and continuous variables, respectively. To ensure genotyping quality, Hardy-Weinberg disequilibrium tests can be performed on cases and controls separately. Significant deviation from Hardy-Weinberg equilibrium (HWE) in both cases and controls for individual markers can be indicative of genotyping errors. If HWE is violated in a majority of markers, it is indicative of population substructure that should be further investigated. Moreover, Hardy-Weinberg disequilibrium in cases only can indicate genetic association of the markers with the disease. B. Weir, Genetic Data Analysis, Sinauer (1990).

To test whether an allele of a single SNP is associated with the case or control status of a phenotypic trait, one skilled in the art can compare allele frequencies in cases and controls. Standard chi-squared tests and Fisher exact tests can be carried out on a 2×2 table (2 SNP alleles×2 outcomes in the categorical trait of interest). To test whether genotypes of a SNP are associated, chi-squared tests can be carried out on a 3×2 table (3 genotypes×2 outcomes). Score tests are also carried out for genotypic association to contrast the three genotypic frequencies (major homozygotes, heterozygotes and minor homozygotes) in cases and controls, and to look for trends using 3 different modes of inheritance, namely dominant (with contrast coefficients 2, −1, −1), additive or allelic (with contrast coefficients 1, 0, −1) and recessive (with contrast coefficients 1, 1, −2). Odds ratios for minor versus major alleles, and odds ratios for heterozygote and homozygote variants versus the wild type genotypes are calculated with the desired confidence limits, usually 95%.

In order to control for confounders and to test for interaction and effect modifiers, stratified analyses may be performed using stratified factors that are likely to be confounding, including demographic information such as age, ethnicity, and gender, or an interacting element or effect modifier, such as a known major gene (e.g., APOE for Alzheimer's disease or HLA genes for autoimmune diseases), or environmental factors such as smoking in lung cancer. Stratified association tests may be carried out using Cochran-Mantel-Haenszel tests that take into account the ordinal nature of genotypes with 0, 1, and 2 variant alleles. Exact tests by StatXact may also be performed when computationally possible. Another way to adjust for confounding effects and test for interactions is to perform stepwise multiple logistic regression analysis using statistical packages such as SAS or R. Logistic regression is a model-building technique in which the best fitting and most parsimonious model is built to describe the relation between the dichotomous outcome (for instance, getting a certain disease or not) and a set of independent variables (for instance, genotypes of different associated genes, and the associated demographic and environmental factors). The most common model is one in which the logit transformation of the odds ratios is expressed as a linear combination of the variables (main effects) and their cross-product terms (interactions). Hosmer and Lemeshow, Applied Logistic Regression, Wiley (2000). To test whether a certain variable or interaction is significantly associated with the outcome, coefficients in the model are first estimated and then tested for statistical significance of their departure from zero.

In addition to performing association tests one marker at a time, haplotype association analysis may also be performed to study a number of markers that are closely linked together. Haplotype association tests can have better power than genotypic or allelic association tests when the tested markers are not the disease-causing mutations themselves but are in linkage disequilibrium with such mutations. The test will even be more powerful if the disease is indeed caused by a combination of alleles on a haplotype (e.g., APOE is a haplotype formed by 2 SNPs that are very close to each other). In order to perform haplotype association effectively, marker-marker linkage disequilibrium measures, both D′ and r², are typically calculated for the markers within a gene to elucidate the haplotype structure. Recent studies in linkage disequilibrium indicate that SNPs within a gene are organized in block pattern, and a high degree of linkage disequilibrium exists within blocks and very little linkage disequilibrium exists between blocks. Daly et al, Nature Genetics 29:232-235 (2001). Haplotype association with the disease status can be performed using such blocks once they have been elucidated.

Haplotype association tests can be carried out in a similar fashion as the allelic and genotypic association tests. Each haplotype in a gene is analogous to an allele in a multi-allelic marker. One skilled in the art can either compare the haplotype frequencies in cases and controls or test genetic association with different pairs of haplotypes. It has been proposed that score tests can be done on haplotypes using the program “haplo.score.” Schaid et al, Am J Hum Genet 70:425-434 (2002). In that method, haplotypes are first inferred by EM algorithm and score tests are carried out with a generalized linear model (GLM) framework that allows the adjustment of other factors.

An important decision in the performance of genetic association tests is the determination of the significance level at which significant association can be declared when the P value of the tests reaches that level. In an exploratory analysis where positive hits will be followed up in subsequent confirmatory testing, an unadjusted P value<0.2 (a significance level on the lenient side), for example, may be used for generating hypotheses for significant association of a SNP with certain phenotypic characteristics of a disease. It is preferred that a p-value<0.05 (a significance level traditionally used in the art) is achieved in order for a SNP to be considered to have an association with a disease. It is more preferred that a p-value<0.01 (a significance level on the stringent side) is achieved for an association to be declared. When hits are followed up in confirmatory analyses in more samples of the same source or in different samples from different sources, adjustment for multiple testing will be performed as to avoid excess number of hits while maintaining the experiment-wide error rates at 0.05. While there are different methods to adjust for multiple testing to control for different kinds of error rates, a commonly used but rather conservative method is Bonferroni correction to control the experiment-wise or family-wise error rate. Westfall et al., Multiple comparisons and multiple tests, SAS Institute (1999). Permutation tests to control for the false discovery rates, FDR, can be more powerful. Benjamini and Hochberg, Journal of the Royal Statistical Society, Series B 57:1289-1300 (1995); Westfall and Young, Resampling-based Multiple Testing, Wiley (1993). Such methods to control for multiplicity would be preferred when the tests are dependent and controlling for false discovery rates is sufficient as opposed to controlling for the experiment-wise error rates.

In replication studies using samples from different populations after statistically significant markers have been identified in the exploratory stage, meta-analyses can then be performed by combining evidence of different studies. Modern Epidemiology 643-673, Lippincott, Williams & Wilkins (1998). If available, association results known in the art for the same SNPs can be included in the meta-analyses.

Since both genotyping and disease status classification can involve errors, sensitivity analyses may be performed to see how odds ratios and p-values would change upon various estimates on genotyping and disease classification error rates.

It has been well known that subpopulation-based sampling bias between cases and controls can lead to spurious results in case-control association studies when prevalence of the disease is associated with different subpopulation groups. Ewens and Spielman, Am J Hum Genet 62:450-458 (1995). Such bias can also lead to a loss of statistical power in genetic association studies. To detect population stratification, Pritchard and Rosenberg suggested typing markers that are unlinked to the disease and using results of association tests on those markers to determine whether there is any population stratification. Pritchard et al., Am J Hum Gen 65:220-228 (1999). When stratification is detected, the genomic control (GC) method as proposed by Devlin and Roeder can be used to adjust for the inflation of test statistics due to population stratification. Devlin et al., Biometrics 55:997-1004 (1999). The GC method is robust to changes in population structure levels as well as being applicable to DNA pooling designs. Devlin et al., Genet Epidem 21:273-284 (2001).

While Pritchard's method recommended using 15-20 unlinked microsatellite markers, it suggested using more than 30 biallelic markers to get enough power to detect population stratification. For the GC method, it has been shown that about 60-70 biallelic markers are sufficient to estimate the inflation factor for the test statistics due to population stratification. Bacanu et al., Am J Hum Genet 66:1933-1944 (2000). Hence, 70 intergenic SNPs can be chosen in unlinked regions as indicated in a genome scan. Kehoe et al., Hum Mol Genet 8:237-245 (1999).

Once individual risk factors, genetic or non-genetic, have been found for the predisposition to disease, the next step is to set up a classification/prediction scheme to predict the category (for instance, disease or no-disease) that an individual will be in depending on his genotypes of associated SNPs and other non-genetic risk factors. Logistic regression for discrete trait and linear regression for continuous trait are standard techniques for such tasks. Draper and Smith, Applied Regression Analysis, Wiley (1998). Moreover, other techniques can also be used for setting up classification. Such techniques include, but are not limited to, MART, CART, neural network, and discriminant analyses that are suitable for use in comparing the performance of different methods. The Elements of Statistical Learning, Hastie, Tibshirani & Friedman, Springer (2002).

For further information about genetic association studies, see Balding, “A tutorial on statistical methods for population association studies”, Nature Reviews Genetics 7, 781 (2006).

Disease Diagnosis and Predisposition Screening

Information on association/correlation between genotypes and disease-related phenotypes can be exploited in several ways. For example, in the case of a highly statistically significant association between one or more SNPs with predisposition to a disease for which treatment is available, detection of such a genotype pattern in an individual may justify immediate administration of treatment, or at least the institution of regular monitoring of the individual. Detection of the susceptibility alleles associated with serious disease in a couple contemplating having children may also be valuable to the couple in their reproductive decisions. In the case of a weaker but still statistically significant association between a SNP and a human disease, immediate therapeutic intervention or monitoring may not be justified after detecting the susceptibility allele or SNP. Nevertheless, the subject can be motivated to begin simple life-style changes (e.g., diet, exercise) that can be accomplished at little or no cost to the individual but would confer potential benefits in reducing the risk of developing conditions for which that individual may have an increased risk by virtue of having the risk allele(s).

The SNPs of the invention may contribute to responsiveness of an individual to statin treatment, or to the development of CVD (e.g., CHD, such as MI), in different ways. Some polymorphisms occur within a protein coding sequence and contribute to disease phenotype by affecting protein structure. Other polymorphisms occur in noncoding regions but may exert phenotypic effects indirectly via influence on, for example, replication, transcription, and/or translation. A single SNP may affect more than one phenotypic trait. Likewise, a single phenotypic trait may be affected by multiple SNPs in different genes.

As used herein, the terms “diagnose,” “diagnosis,” and “diagnostics” include, but are not limited to, any of the following: detection of CVD (e.g., CHD, such as MI) that an individual may presently have, predisposition/susceptibility/predictive screening (i.e., determining whether an individual has an increased or decreased risk of developing CVD in the future), predicting recurrence of CVD (e.g., recurrent MI) in an individual, determining a particular type or subclass of CVD in an individual who currently or previously had CVD, confirming or reinforcing a previously made diagnosis of CVD, evaluating an individual's likelihood of responding positively to a particular treatment or therapeutic agent (i.e., benefiting) such as statin treatment (particularly treatment or prevention of CVD, especially CHD such as MI, using statins), determining or selecting a therapeutic or preventive strategy that an individual is most likely to positively respond to (e.g., selecting a particular therapeutic agent such as a statin, or combination of therapeutic agents, or selecting a particular statin from among other statins, or determining a dosing regimen or selecting a dosage formulation, etc.), classifying (or confirming/reinforcing) an individual as a responder/non-responder (or determining a particular subtype of responder/non-responder) with respect to the individual's response to a drug treatment such as statin treatment, and predicting whether a patient is likely to experience toxic effects from a particular treatment or therapeutic compound. Such diagnostic uses can be based on the SNPs individually or a unique combination or SNPs disclosed herein, as well as SNP haplotypes.

Haplotypes are particularly useful in that, for example, fewer SNPs can be genotyped to determine if a particular genomic region harbors a locus that influences a particular phenotype, such as in linkage disequilibrium-based SNP association analysis.

Linkage disequilibrium (LD) refers to the co-inheritance of alleles (e.g., alternative nucleotides) at two or more different SNP sites at frequencies greater than would be expected from the separate frequencies of occurrence of each allele in a given population. The expected frequency of co-occurrence of two alleles that are inherited independently is the frequency of the first allele multiplied by the frequency of the second allele. Alleles that co-occur at expected frequencies are said to be in “linkage equilibrium.” In contrast, LD refers to any non-random genetic association between allele(s) at two or more different SNP sites, which is generally due to the physical proximity of the two loci along a chromosome. LD can occur when two or more SNPs sites are in close physical proximity to each other on a given chromosome and therefore alleles at these SNP sites will tend to remain unseparated for multiple generations with the consequence that a particular nucleotide (allele) at one SNP site will show a non-random association with a particular nucleotide (allele) at a different SNP site located nearby. Hence, genotyping one of the SNP sites will give almost the same information as genotyping the other SNP site that is in LD.

Various degrees of LD can be encountered between two or more SNPs with the result being that some SNPs are more closely associated (i.e., in stronger LD) than others. Furthermore, the physical distance over which LD extends along a chromosome differs between different regions of the genome, and therefore the degree of physical separation between two or more SNP sites necessary for LD to occur can differ between different regions of the genome.

For diagnostic purposes and similar uses, if a particular SNP site is found to be useful for, for example, predicting an individual's response to statin treatment or an individual's susceptibility to CVD, then the skilled artisan would recognize that other SNP sites which are in LD with this SNP site would also be useful for the same purposes. Thus, polymorphisms (e.g., SNPs and/or haplotypes) that are not the actual disease-causing (causative) polymorphisms, but are in LD with such causative polymorphisms, are also useful. In such instances, the genotype of the polymorphism(s) that is/are in LD with the causative polymorphism is predictive of the genotype of the causative polymorphism and, consequently, predictive of the phenotype (e.g., response to statin treatment or risk for developing CVD) that is influenced by the causative SNP(s). Therefore, polymorphic markers that are in LD with causative polymorphisms are useful as diagnostic markers, and are particularly useful when the actual causative polymorphism(s) is/are unknown.

Examples of polymorphisms that can be in LD with one or more causative polymorphisms (and/or in LD with one or more polymorphisms that have a significant statistical association with a condition) and therefore useful for diagnosing the same condition that the causative/associated SNP(s) is used to diagnose, include other SNPs in the same gene, protein-coding, or mRNA transcript-coding region as the causative/associated SNP, other SNPs in the same exon or same intron as the causative/associated SNP, other SNPs in the same haplotype block as the causative/associated SNP, other SNPs in the same intergenic region as the causative/associated SNP, SNPs that are outside but near a gene (e.g., within 6 kb on either side, 5′ or 3′, of a gene boundary) that harbors a causative/associated SNP, etc. Such useful LD SNPs can be selected from among the SNPs disclosed in Table 3, for example.

Linkage disequilibrium in the human genome is reviewed in Wall et al., “Haplotype blocks and linkage disequilibrium in the human genome,” Nat Rev Genet 4(8):587-97 (August 2003); Garner et al., “On selecting markers for association studies: patterns of linkage disequilibrium between two and three diallelic loci,” Genet Epidemiol 24(1):57-67 (January 2003); Ardlie et al., “Patterns of linkage disequilibrium in the human genome,” Nat Rev Genet 3(4):299-309 (April 2002); erratum in Nat Rev Genet 3(7):566 (July 2002); and Remm et al., “High-density genotyping and linkage disequilibrium in the human genome using chromosome 22 as a model,” Curr Opin Chem Biol 6(1):24-30 (February 2002); J. B. S. Haldane, “The combination of linkage values, and the calculation of distances between the loci of linked factors,” J Genet 8:299-309 (1919); G. Mendel, Versuche über Pflanzen-Hybriden. Verhandlungen des naturforschenden Vereines in Brünn (Proceedings of the Natural History Society of Brünn) (1866); Genes IV, B. Lewin, ed., Oxford University Press, N.Y. (1990); D. L. Hartl and A. G. Clark Principles of Population Genetics 2^(nd) ed., Sinauer Associates, Inc., Mass. (1989); J. H. Gillespie Population Genetics: A Concise Guide. 2^(nd) ed., Johns Hopkins University Press (2004); R. C. Lewontin, “The interaction of selection and linkage. I. General considerations; heterotic models,” Genetics 49:49-67 (1964); P. G. Hoel, Introduction to Mathematical Statistics 2^(nd) ed., John Wiley & Sons, Inc., N.Y. (1954); R. R. Hudson, “Two-locus sampling distributions and their application,” Genetics 159:1805-1817 (2001); A. P. Dempster, N. M. Laird, D. B. Rubin, “Maximum likelihood from incomplete data via the EM algorithm,” J R Stat Soc 39:1-38 (1977); L. Excoffier, M. Slatkin, “Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population,” Mol Biol Evol 12(5):921-927 (1995); D. A. Tregouet, S. Escolano, L. Tiret, A. Mallet, J. L. Golmard, “A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm,” Ann Hum Genet 68(Pt 2):165-177 (2004); A. D. Long and C. H. Langley C H, “The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits,” Genome Research 9:720-731 (1999); A. Agresti, Categorical Data Analysis, John Wiley & Sons, Inc., N.Y. (1990); K. Lange, Mathematical and Statistical Methods for Genetic Analysis, Springer-Verlag New York, Inc., N.Y. (1997); The International HapMap Consortium, “The International HapMap Project,” Nature 426:789-796 (2003); The International HapMap Consortium, “A haplotype map of the human genome,” Nature 437:1299-1320 (2005); G. A. Thorisson, A. V. Smith, L. Krishnan, L. D. Stein, “The International HapMap Project Web Site,” Genome Research 15:1591-1593 (2005); G. McVean, C. C. A. Spencer, R. Chaix, “Perspectives on human genetic variation from the HapMap project,” PLoS Genetics 1(4):413-418 (2005); J. N. Hirschhorn, M. J. Daly, “Genome-wide association studies for common diseases and complex traits,” Nat Genet 6:95-108 (2005); S. J. Schrodi, “A probabilistic approach to large-scale association scans: a semi-Bayesian method to detect disease-predisposing alleles,” SAGMB 4(1):31 (2005); W. Y. S. Wang, B. J. Barratt, D. G. Clayton, J. A. Todd, “Genome-wide association studies: theoretical and practical concerns,” Nat Rev Genet 6:109-118 (2005); J. K. Pritchard, M. Przeworski, “Linkage disequilibrium in humans: models and data,” Am J Hum Genet 69:1-14 (2001).

As discussed above, an aspect of the present invention relates to SNPs that are in LD with an interrogated SNP and which can also be used as valid markers for determining an individual's likelihood of benefiting from statin treatment, or whether an individual has an increased or decreased risk of having or developing CVD. As used herein, the term “interrogated SNP” refers to SNPs that have been found to be associated with statin response, particularly for reducing CVD risk, using genotyping results and analysis, or other appropriate experimental method as exemplified in the working examples described in this application. As used herein, the term “LD SNP” refers to a SNP that has been characterized as a SNP associated with statin response or an increased or decreased risk of CVD due to their being in LD with the “interrogated SNP” under the methods of calculation described in the application. Below, applicants describe the methods of calculation with which one of ordinary skilled in the art may determine if a particular SNP is in LD with an interrogated SNP. The parameter r² is commonly used in the genetics art to characterize the extent of linkage disequilibrium between markers (Hudson, 2001). As used herein, the term “in LD with” refers to a particular SNP that is measured at above the threshold of a parameter such as r² with an interrogated SNP.

It is now common place to directly observe genetic variants in a sample of chromosomes obtained from a population. Suppose one has genotype data at two genetic markers located on the same chromosome, for the markers A and B. Further suppose that two alleles segregate at each of these two markers such that alleles A₁ and A₂ can be found at marker A and alleles B₁ and B₂ at marker B. Also assume that these two markers are on a human autosome. If one is to examine a specific individual and find that they are heterozygous at both markers, such that their two-marker genotype is A₁A₂B₁B₂, then there are two possible configurations: the individual in question could have the alleles A₁B₁ on one chromosome and A₂B₂ on the remaining chromosome; alternatively, the individual could have alleles A₁B₂ on one chromosome and A₂B, on the other. The arrangement of alleles on a chromosome is called a haplotype. In this illustration, the individual could have haplotypes A₁B₁/A₂B₂ or A₁B₂/A₂B₁ (see Hartl and Clark (1989) for a more complete description). The concept of linkage equilibrium relates the frequency of haplotypes to the allele frequencies.

Assume that a sample of individuals is selected from a larger population. Considering the two markers described above, each having two alleles, there are four possible haplotypes: A₁B₁, A₁B₂, A₂B₁ and A₂B₂. Denote the frequencies of these four haplotypes with the following notation. P ₁₁=freq(A ₁ B ₁)  (1) P ₁₂=freq(A ₁ B ₂)  (2) P ₂₁=freq(A ₂ B ₁)  (3) P ₂₂=freq(A ₂ B ₂)  (4) The allele frequencies at the two markers are then the sum of different haplotype frequencies, it is straightforward to write down a similar set of equations relating single-marker allele frequencies to two-marker haplotype frequencies: p ₁=freq(A ₁)=P ₁₁ +P ₁₂  (5) p ₂=freq(A ₂)=P ₂₁ +P ₂₂  (6) q ₁=freq(B ₁)=P ₁₁ +P ₁₂  (7) q ₂=freq(B ₂)=P ₁₂ +P ₂₂  (8) Note that the four haplotype frequencies and the allele frequencies at each marker must sum to a frequency of 1. P ₁₁ +P ₁₂ +P ₂₂=1  (9) p ₁ +p ₂=1  (10) q ₁ +q ₂=1  (11) If there is no correlation between the alleles at the two markers, one would expect that the frequency of the haplotypes would be approximately the product of the composite alleles. Therefore, P ₁₁ ≈p ₁ q ₁  (12) P ₁₂ ≈p ₁ q ₂  (13) P ₂₁ ≈p ₂ q ₁  (14) P ₂₂ ≈p ₂ q ₂  (15) These approximating equations (12)-(15) represent the concept of linkage equilibrium where there is independent assortment between the two markers—the alleles at the two markers occur together at random. These are represented as approximations because linkage equilibrium and linkage disequilibrium are concepts typically thought of as properties of a sample of chromosomes; and as such they are susceptible to stochastic fluctuations due to the sampling process. Empirically, many pairs of genetic markers will be in linkage equilibrium, but certainly not all pairs.

Having established the concept of linkage equilibrium above, applicants can now describe the concept of linkage disequilibrium (LD), which is the deviation from linkage equilibrium. Since the frequency of the A₁B₁ haplotype is approximately the product of the allele frequencies for A₁ and B₁ under the assumption of linkage equilibrium as stated mathematically in (12), a simple measure for the amount of departure from linkage equilibrium is the difference in these two quantities, D, D=P ₁₁ −p ₁ q ₁  (16) D=0 indicates perfect linkage equilibrium. Substantial departures from D=0 indicates LD in the sample of chromosomes examined. Many properties of D are discussed in Lewontin (1964) including the maximum and minimum values that D can take. Mathematically, using basic algebra, it can be shown that D can also be written solely in terms of haplotypes: D=P ₁₁ P ₂₂ −P ₁₂ P ₂₁  (17) If one transforms D by squaring it and subsequently dividing by the product of the allele frequencies of A₁, A₂, B, and B₂, the resulting quantity, called r², is equivalent to the square of the Pearson's correlation coefficient commonly used in statistics (e.g., Hoel, 1954).

$\begin{matrix} {r^{2} = \frac{D^{2}}{p_{1}p_{2}q_{1}q_{2}}} & (18) \end{matrix}$

As with D, values of r² close to 0 indicate linkage equilibrium between the two markers examined in the sample set. As values of r² increase, the two markers are said to be in linkage disequilibrium. The range of values that r² can take are from 0 to 1. r²=1 when there is a perfect correlation between the alleles at the two markers.

In addition, the quantities discussed above are sample-specific. And as such, it is necessary to formulate notation specific to the samples studied. In the approach discussed here, three types of samples are of primary interest: (i) a sample of chromosomes from individuals affected by a disease-related phenotype (cases), (ii) a sample of chromosomes obtained from individuals not affected by the disease-related phenotype (controls), and (iii) a standard sample set used for the construction of haplotypes and calculation pairwise linkage disequilibrium. For the allele frequencies used in the development of the method described below, an additional subscript will be added to denote either the case or control sample sets. p _(1,cs)=freq(A ₁ in cases)  (19) p _(2,cs)=freq(A ₂ in cases)  (20) q _(1,cs)=freq(B ₁ in cases)  (21) q _(2,cs)=freq(B ₂ in cases)  (22) Similarly, p _(1,ct)=freq(A ₁ in cases)  (23) p _(2,ct)=freq(A ₂ in cases)  (24) q _(1,ct)=freq(B ₁ in cases)  (25) q _(2,ct)=freq(B ₂ in cases)  (26)

As a well-accepted sample set is necessary for robust linkage disequilibrium calculations, data obtained from the International HapMap project (The International HapMap Consortium 2003, 2005; Thorisson et al, 2005; McVean et al, 2005) can be used for the calculation of pairwise r² values. Indeed, the samples genotyped for the International HapMap Project were selected to be representative examples from various human sub-populations with sufficient numbers of chromosomes examined to draw meaningful and robust conclusions from the patterns of genetic variation observed. The International HapMap project website (hapmap.org) contains a description of the project, methods utilized and samples examined. It is useful to examine empirical data to get a sense of the patterns present in such data.

Haplotype frequencies were explicit arguments in equation (18) above. However, knowing the 2-marker haplotype frequencies requires that phase to be determined for doubly heterozygous samples. When phase is unknown in the data examined, various algorithms can be used to infer phase from the genotype data. This issue was discussed earlier where the doubly heterozygous individual with a 2-SNP genotype of A₁A₂B₁B₂ could have one of two different sets of chromosomes: A₁B₁/A₂B₂ or A₁B₂/A₂B₁. One such algorithm to estimate haplotype frequencies is the expectation-maximization (EM) algorithm first formalized by Dempster et al. (1977). This algorithm is often used in genetics to infer haplotype frequencies from genotype data (e.g. Excoffier and Slatkin (1995); Tregouet et al. (2004)). It should be noted that for the two-SNP case explored here, EM algorithms have very little error provided that the allele frequencies and sample sizes are not too small. The impact on r² values is typically negligible.

As correlated genetic markers share information, interrogation of SNP markers in LD with a disease-associated SNP marker can also have sufficient power to detect disease association (Long and Langley (1999)). The relationship between the power to directly find disease-associated alleles and the power to indirectly detect disease-association was investigated by Pritchard and Przeworski (2001). In a straight-forward derivation, it can be shown that the power to detect disease association indirectly at a marker locus in linkage disequilibrium with a disease-association locus is approximately the same as the power to detect disease-association directly at the disease-association locus if the sample size is increased by a factor of

$\frac{1}{r^{2}}$ (the reciprocal of equation 18) at the marker in comparison with the disease-association locus.

Therefore, if one calculated the power to detect disease-association indirectly with an experiment having N samples, then equivalent power to directly detect disease-association (at the actual disease-susceptibility locus) would necessitate an experiment using approximately r²N samples. This elementary relationship between power, sample size and linkage disequilibrium can be used to derive an r² threshold value useful in determining whether or not genotyping markers in linkage disequilibrium with a SNP marker directly associated with disease status has enough power to indirectly detect disease-association.

To commence a derivation of the power to detect disease-associated markers through an indirect process, define the effective chromosomal sample size as

$\begin{matrix} {{n = \frac{4\; N_{cs}N_{ct}}{N_{cs} + N_{ct}}};} & (27) \end{matrix}$ where N_(cs) and N_(ct) are the numbers of diploid cases and controls, respectively. This is necessary to handle situations where the numbers of cases and controls are not equivalent. For equal case and control sample sizes, N_(cs)=N_(ct)=N, the value of the effective number of chromosomes is simply n=2N—as expected. Let power be calculated for a significance level α (such that traditional P-values below α will be deemed statistically significant). Define the standard Gaussian distribution function as Φ(⋅). Mathematically,

$\begin{matrix} {{\Phi(x)} = {\frac{1}{\sqrt{2\;\pi}}{\int_{- \infty}^{x}{e^{- \frac{\theta^{2}}{2}}\ d\;\theta}}}} & (28) \end{matrix}$ Alternatively, the following error function notation (Erf) may also be used,

$\begin{matrix} {{\Phi(x)} = {\frac{1}{2}\left\lbrack {1 + {{Erf}\left( \frac{x}{\sqrt{2}} \right)}} \right\rbrack}} & (29) \end{matrix}$

For example, Φ(1.644854)=0.95. The value of r² may be derived to yield a pre-specified minimum amount of power to detect disease association though indirect interrogation. Noting that the LD SNP marker could be the one that is carrying the disease-association allele, therefore that this approach constitutes a lower-bound model where all indirect power results are expected to be at least as large as those interrogated.

Denote by β the error rate for not detecting truly disease-associated markers. Therefore, 1−β is the classical definition of statistical power. Substituting the Pritchard-Pzreworski result into the sample size, the power to detect disease association at a significance level of α is given by the approximation

$\begin{matrix} {{{1 - \beta} \cong {\Phi\left\lbrack {\frac{{q_{1,{cs}} - q_{1,{ct}}}}{\sqrt{\frac{{q_{1,{cs}}\left( {1 - q_{1,{cs}}} \right)} + {q_{1,{ct}}\left( {1 - q_{1,{ct}}} \right)}}{r^{2}n}}} - Z_{1 - \frac{\alpha}{2}}} \right\rbrack}};} & (30) \end{matrix}$ where Z_(u) is the inverse of the standard normal cumulative distribution evaluated at u(u∈(0,1)). Z_(u)=Φ⁻¹(u), where Φ(Φ⁻¹(u))=Φ⁻¹ ((u))=u. For example, setting α=0.05, and therefore 1−α/2=0.975, one obtains Z_(0.975)=1.95996. Next, setting power equal to a threshold of a minimum power of T,

$\begin{matrix} {{T = {\Phi\left\lbrack {\frac{{q_{1,{cs}} - q_{1,{ct}}}}{\sqrt{\frac{{q_{1,{cs}}\left( {1 - q_{1,{cs}}} \right)} + {q_{1,{ct}}\left( {1 - q_{1,{ct}}} \right)}}{r^{2}n}}} - Z_{1 - \frac{\alpha}{2}}} \right\rbrack}};} & (31) \end{matrix}$ and solving for r², the following threshold r² is obtained:

$\begin{matrix} {r_{T}^{2} = {\frac{\left\lfloor {{q_{1,{cs}}\left( {1 - q_{1,{cs}}} \right)} + {q_{1,{ct}}\left( {1 - q_{1,{ct}}} \right)}} \right\rfloor}{{n\left( {q_{1,{cs}} - q_{1,{ct}}} \right)}^{2}}\left\lbrack {{\Phi^{- 1}(T)} + Z_{1 - \frac{\alpha}{2}}} \right\rbrack}^{2}} & (32) \\ {r_{T}^{2} = {\frac{\left( {Z_{T} + Z_{1 - \frac{\alpha}{2}}} \right)^{2}}{n}\left\lbrack \frac{q_{1,{cs}} - \left( q_{1,{cs}} \right)^{2} + q_{1,{ct}} - \left( q_{1,{ct}} \right)^{2}}{\left( {q_{1,{cs}} - q_{1,{ct}}} \right)^{2}} \right\rbrack}} & (33) \end{matrix}$

Suppose that r² is calculated between an interrogated SNP and a number of other SNPs with varying levels of LD with the interrogated SNP. The threshold value r_(T) ² is the minimum value of linkage disequilibrium between the interrogated SNP and the potential LD SNPs such that the LD SNP still retains a power greater or equal to T for detecting disease-association. For example, suppose that SNP rs200 is genotyped in a case-control disease-association study and it is found to be associated with a disease phenotype. Further suppose that the minor allele frequency in 1,000 case chromosomes was found to be 16% in contrast with a minor allele frequency of 10% in 1,000 control chromosomes. Given those measurements one could have predicted, prior to the experiment, that the power to detect disease association at a significance level of 0.05 was quite high—approximately 98% using a test of allelic association. Applying equation (32) one can calculate a minimum value of r² to indirectly assess disease association assuming that the minor allele at SNP rs200 is truly disease-predisposing for a threshold level of power. If one sets the threshold level of power to be 80%, then r²=0.489 given the same significance level and chromosome numbers as above. Hence, any SNP with a pairwise r² value with rs200 greater than 0.489 is expected to have greater than 80% power to detect the disease association. Further, this is assuming the conservative model where the LD SNP is disease-associated only through linkage disequilibrium with the interrogated SNP rs200.

Imputation

Genotypes of SNPs can be imputed without actually having to be directly genotyped (referred to as “imputation”), by using known haplotype information. Imputation is a process to provide “missing” data, either missing individual genotypes (alleles) or missing SNPs and concomitant genotypes, which have not been directly genotyped (i.e., assayed). Imputation is particularly useful for identifying disease associations for specific ungenotyped SNPs by inferring the missing genotypes to these ungenotyped SNPs. Although the process uses similar information to LD, since the phasing and imputation process uses information from multiple SNPs at the same time, the phased haplotype, it is able to infer the genotype and achieve high identifiable accuracy. Genotype information (such as from the HapMap project by The International HapMap Consortium, NCBI, NLM, NIH) can be used to infer haplotype phase and impute genotypes for SNPs that are not directly genotyped in a given individual or sample set (such as for a disease association study). In general, imputation uses a reference dataset in which the genotypes of potential SNPs that are to be tested for disease association have been determined in multiple individuals (such as in HapMap); the individuals in the reference dataset are then haplotype phased. This phasing can be done with independent programs such as fastPHASE (Sheet and Stephens, Am J Hum Genet (2006) 76: 629-644) or a combination program such as BEAGLE which does both the phasing and the imputation. The reference phased haplotypes and process can be checked using the children of the HapMap individual parents, among other mechanisms. Once the reference phased haplotypes have been created, the imputation of additional individuals for SNPs genotyped or complete sets of SNPs that have not been directly genotyped can then proceed. The HapMap dataset is particularly useful as the reference dataset, however other datasets can be used. Since the imputation creates new concommitant phased haplotypes for individuals in the association study and these contain other SNPs within the genomic region, these ungenotyped but imputed SNPs can also be tested for disease associations (or other traits). Certain exemplary methods for haplotype phase inference and imputation of missing genotypes utilize the BEAGLE genetic analysis program, (Browning, Hum Genet (2008) 124:439-450).

Thus, SNPs for which genotypes are imputed can be tested for association with a disease or other trait even though these SNPs are not directly genotyped. The SNPs for which genotypes are imputed have genotype data available in the reference dataset, e.g. HapMap individuals, but they are not directly genotyped in a particular individual or sample set (such as in a particular disease association study).

In addition to using a reference dataset (e.g., HapMap) to impute genotypes of SNPs that are not directly genotyped in a study, imputation can provide genotypes of SNPs that were directly genotyped in a study but for which the genotypes are missing in some or most of the individuals for some reason, such as because they failed to pass quality control. Imputation can also be used to combine genotyping results from multiple studies in which different sets of SNPs were genotyped to construct a complete meta-analysis. For example, genotyped and imputed genotyped SNP results from multiple different studies can be combined, and the overlapping SNP genotypes (e.g., genotyped in one study, imputed in another study or imputed in both or genotyped in both) can be analyzed across all of the studies (Browning, Hum Genet (2008) 124:439-450).

For a review of imputation (as well as the BEAGLE program), see Browning, “Missing data imputation and haplotype phase inference for genome-wide association studies”, Hum Genet (2008) 124:439-450 and Browning et al. “A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals”, Am J Hum Genet. (2009) February; 84(2):210-23, each of which is incorporated herein by reference in its entirety.

The contribution or association of particular SNPs with statin response or disease phenotypes, such as CVD, enables the SNPs of the present invention to be used to develop superior diagnostic tests capable of identifying individuals who express a detectable trait, such as reduced risk for CVD (particularly CHD, such as MI) in response to statin treatment, as the result of a specific genotype, or individuals whose genotype places them at an increased or decreased risk of developing a detectable trait at a subsequent time as compared to individuals who do not have that genotype. As described herein, diagnostics may be based on a single SNP or a group of SNPs. Combined detection of a plurality of SNPs (for example, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 24, 25, 30, 32, 48, 50, 64, 96, 100, or any other number in-between, or more, of the SNPs provided in Table 1 and/or Table 2) typically increases the probability of an accurate diagnosis. For example, the presence of a single SNP known to correlate with CVD might indicate a probability of 20% that an individual has or is at risk of developing CVD, whereas detection of five SNPs, each of which correlates with CVD, might indicate a probability of 80% that an individual has or is at risk of developing CVD. To further increase the accuracy of diagnosis or predisposition screening, analysis of the SNPs of the present invention can be combined with that of other polymorphisms or other risk factors of CVD, such as disease symptoms, pathological characteristics, family history, diet, environmental factors, or lifestyle factors.

It will be understood by practitioners skilled in the treatment or diagnosis of CVD that the present invention generally does not intend to provide an absolute identification of individuals who benefit from statin treatment or individuals who are at risk (or less at risk) of developing CVD, but rather to indicate a certain increased (or decreased) degree or likelihood of responding to statin therapy or developing CVD based on statistically significant association results. However, this information is extremely valuable as it can be used to, for example, encourage individuals to comply with their statin regimens as prescribed by their doctors (even though the benefit of maintaining statin therapy may not be overtly apparent, which often leads to lack of compliance with prescribed statin treatment), to initiate preventive treatments or to allow an individual carrying one or more significant SNPs or SNP haplotypes to foresee warning signs such as minor clinical symptoms, or to have regularly scheduled physical exams to monitor for appearance of a condition in order to identify and begin treatment of the condition at an early stage. Particularly with diseases that are extremely debilitating or fatal if not treated on time, the knowledge of a potential predisposition, even if this predisposition is not absolute, would likely contribute in a very significant manner to treatment efficacy.

The diagnostic techniques of the present invention may employ a variety of methodologies to determine whether a test subject has a SNP or combination of SNPs associated with an increased or decreased risk of developing a detectable trait or whether the individual suffers from a detectable trait as a result of a particular polymorphism/mutation, including, for example, methods which enable the analysis of individual chromosomes for haplotyping, family studies, single sperm DNA analysis, or somatic hybrids. The trait analyzed using the diagnostics of the invention may be any detectable trait that is commonly observed in pathologies and disorders related to CVD or drug response.

Another aspect of the present invention relates to a method of determining whether an individual is at risk (or less at risk) of developing one or more traits or whether an individual expresses one or more traits as a consequence of possessing a particular trait-causing or trait-influencing allele. These methods generally involve obtaining a nucleic acid sample from an individual and assaying the nucleic acid sample to determine which nucleotide(s) is/are present at one or more SNP positions, wherein the assayed nucleotide(s) is/are indicative of an increased or decreased risk of developing the trait or indicative that the individual expresses the trait as a result of possessing a particular trait-causing or trait-influencing allele.

In another embodiment, the SNP detection reagents of the present invention are used to determine whether an individual has one or more SNP allele(s) affecting the level (e.g., the concentration of mRNA or protein in a sample, etc.) or pattern (e.g., the kinetics of expression, rate of decomposition, stability profile, Km, Vmax, etc.) of gene expression (collectively, the “gene response” of a cell or bodily fluid). Such a determination can be accomplished by screening for mRNA or protein expression (e.g., by using nucleic acid arrays, RT-PCR, TaqMan assays, or mass spectrometry), identifying genes having altered expression in an individual, genotyping SNPs disclosed in Table 1 and/or Table 2 that could affect the expression of the genes having altered expression (e.g., SNPs that are in and/or around the gene(s) having altered expression, SNPs in regulatory/control regions, SNPs in and/or around other genes that are involved in pathways that could affect the expression of the gene(s) having altered expression, or all SNPs could be genotyped), and correlating SNP genotypes with altered gene expression. In this manner, specific SNP alleles at particular SNP sites can be identified that affect gene expression.

Therapeutics, Pharmacogenomics, and Drug Development

Therapeutic Methods and Compositions

In certain aspects of the invention, there are provided methods of assaying (i.e., testing) one or more SNPs provided by the present invention in an individual's nucleic acids, and administering a therapeutic or preventive agent to the individual based on the allele(s) present at the SNP(s) having indicated that the individual can benefit from the therapeutic or preventive agent.

In further aspects of the invention, there are provided methods of assaying one or more SNPs provided by the present invention in an individual's nucleic acids, and administering a diagnostic agent (e.g., an imaging agent), or otherwise carrying out further diagnostic procedures on the individual, based on the allele(s) present at the SNP(s) having indicated that the diagnostic agents or diagnostics procedures are justified in the individual.

In yet other aspects of the invention, there is provided a pharmaceutical pack comprising a therapeutic agent (e.g., a small molecule drug, antibody, peptide, antisense or RNAi nucleic acid molecule, etc.) and a set of instructions for administration of the therapeutic agent to an individual who has been tested for one or more SNPs provided by the present invention.

Pharmacogenomics

The present invention provides methods for assessing the pharmacogenomics of a subject harboring particular SNP alleles or haplotypes to a particular therapeutic agent or pharmaceutical compound, or to a class of such compounds. Pharmacogenomics deals with the roles which clinically significant hereditary variations (e.g., SNPs) play in the response to drugs due to altered drug disposition and/or abnormal action in affected persons. See, e.g., Roses, Nature 405, 857-865 (2000); Gould Rothberg, Nature Biotechnology 19, 209-211 (2001); Eichelbaum, Clin Exp Pharmacol Physiol 23(10-11):983-985 (1996); and Linder, Clin Chem 43(2):254-266 (1997). The clinical outcomes of these variations can result in severe toxicity of therapeutic drugs in certain individuals or therapeutic failure of drugs in certain individuals as a result of individual variation in metabolism. Thus, the SNP genotype of an individual can determine the way a therapeutic compound acts on the body or the way the body metabolizes the compound. For example, SNPs in drug metabolizing enzymes can affect the activity of these enzymes, which in turn can affect both the intensity and duration of drug action, as well as drug metabolism and clearance.

The discovery of SNPs in drug metabolizing enzymes, drug transporters, proteins for pharmaceutical agents, and other drug targets has explained why some patients do not obtain the expected drug effects, show an exaggerated drug effect, or experience serious toxicity from standard drug dosages. SNPs can be expressed in the phenotype of the extensive metabolizer and in the phenotype of the poor metabolizer. Accordingly, SNPs may lead to allelic variants of a protein in which one or more of the protein functions in one population are different from those in another population. SNPs and the encoded variant peptides thus provide targets to ascertain a genetic predisposition that can affect treatment modality. For example, in a ligand-based treatment, SNPs may give rise to amino terminal extracellular domains and/or other ligand-binding regions of a receptor that are more or less active in ligand binding, thereby affecting subsequent protein activation. Accordingly, ligand dosage would necessarily be modified to maximize the therapeutic effect within a given population containing particular SNP alleles or haplotypes.

As an alternative to genotyping, specific variant proteins containing variant amino acid sequences encoded by alternative SNP alleles could be identified. Thus, pharmacogenomic characterization of an individual permits the selection of effective compounds and effective dosages of such compounds for prophylactic or therapeutic uses based on the individual's SNP genotype, thereby enhancing and optimizing the effectiveness of the therapy. Furthermore, the production of recombinant cells and transgenic animals containing particular SNPs/haplotypes allow effective clinical design and testing of treatment compounds and dosage regimens. For example, transgenic animals can be produced that differ only in specific SNP alleles in a gene that is orthologous to a human disease susceptibility gene.

Pharmacogenomic uses of the SNPs of the present invention provide several significant advantages for patient care, particularly in predicting an individual's responsiveness to statin treatment (particularly for reducing the risk of CVD, especially CHD such as MI) and in predicting an individual's predisposition to CVD (e.g., CHD such as MI). Pharmacogenomic characterization of an individual, based on an individual's SNP genotype, can identify those individuals unlikely to respond to treatment with a particular medication and thereby allows physicians to avoid prescribing the ineffective medication to those individuals. On the other hand, SNP genotyping of an individual may enable physicians to select the appropriate medication and dosage regimen that will be most effective based on an individual's SNP genotype. This information increases a physician's confidence in prescribing medications and motivates patients to comply with their drug regimens. Furthermore, pharmacogenomics may identify patients predisposed to toxicity and adverse reactions to particular drugs or drug dosages. Adverse drug reactions lead to more than 100,000 avoidable deaths per year in the United States alone and therefore represent a significant cause of hospitalization and death, as well as a significant economic burden on the healthcare system (Pfost et al., Trends in Biotechnology, August 2000.). Thus, pharmacogenomics based on the SNPs disclosed herein has the potential to both save lives and reduce healthcare costs substantially.

Pharmacogenomics in general is discussed further in Rose et al., “Pharmacogenetic analysis of clinically relevant genetic polymorphisms,” Methods Mol Med 85:225-37 (2003). Pharmacogenomics as it relates to Alzheimer's disease and other neurodegenerative disorders is discussed in Cacabelos, “Pharmacogenomics for the treatment of dementia,” Ann Med 34(5):357-79 (2002); Maimone et al., “Pharmacogenomics of neurodegenerative diseases,” Eur J Pharmacol 413(1):11-29 (February 2001); and Poirier, “Apolipoprotein E: a pharmacogenetic target for the treatment of Alzheimer's disease,” Mol Diagn 4(4):335-41 (December 1999). Pharmacogenomics as it relates to cardiovascular disorders is discussed in Siest et al., “Pharmacogenomics of drugs affecting the cardiovascular system,” Clin Chem Lab Med 41(4):590-9 (April 2003); Mukherjee et al., “Pharmacogenomics in cardiovascular diseases,” Prog Cardiovasc Dis 44(6):479-98 (May-June 2002); and Mooser et al., “Cardiovascular pharmacogenetics in the SNP era,” J Thromb Haemost 1(7):1398-402 (July 2003). Pharmacogenomics as it relates to cancer is discussed in McLeod et al., “Cancer pharmacogenomics: SNPs, chips, and the individual patient,” Cancer Invest 21(4):630-40 (2003); and Watters et al., “Cancer pharmacogenomics: current and future applications,” Biochim Biophys Acta 1603(2):99-111 (March 2003).

Clinical Trials

In certain aspects of the invention, there are provided methods of using the SNPs disclosed herein to identify or stratify patient populations for clinical trials of a therapeutic, preventive, or diagnostic agent.

For instance, an aspect of the present invention includes selecting individuals for clinical trials based on their SNP genotype, such as selecting individuals for inclusion in a clinical trial and/or assigning individuals to a particular group within a clinical trial (e.g., an “arm” of the trial). For example, individuals with SNP genotypes that indicate that they are likely to positively respond to a drug can be included in the trials, whereas those individuals whose SNP genotypes indicate that they are less likely to or would not respond to the drug, or who are at risk for suffering toxic effects or other adverse reactions, can be excluded from the clinical trials. This not only can improve the safety of clinical trials, but also can enhance the chances that the trial will demonstrate statistically significant efficacy. Further, one can stratify a prospective trial with patients with different SNP variants to determine the impact of differential drug treatment.

Thus, certain embodiments of the invention provide methods for conducting a clinical trial of a therapeutic agent in which a human is selected for inclusion in the clinical trial and/or assigned to a particular group within a clinical trial based on the presence or absence of one or more SNPs disclosed herein. In certain embodiments, the therapeutic agent is a statin.

In certain exemplary embodiments, SNPs of the invention can be used to select individuals who are unlikely to respond positively to a particular therapeutic agent (or class of therapeutic agents) based on their SNP genotype(s) to participate in a clinical trial of another type of drug that may benefit them. Thus, in certain embodiments, the SNPs of the invention can be used to identify patient populations who do not adequately respond to current treatments and are therefore in need of new therapies. This not only benefits the patients themselves, but also benefits organizations such as pharmaceutical companies by enabling the identification of populations that represent markets for new drugs, and enables the efficacy of these new drugs to be tested during clinical trials directly in individuals within these markets.

The SNP-containing nucleic acid molecules of the present invention are also useful for monitoring the effectiveness of modulating compounds on the expression or activity of a variant gene, or encoded product, particularly in a treatment regimen or in clinical trials. Thus, the gene expression pattern can serve as an indicator for the continuing effectiveness of treatment with the compound, particularly with compounds to which a patient can develop resistance, as well as an indicator for toxicities. The gene expression pattern can also serve as a marker indicative of a physiological response of the affected cells to the compound. Accordingly, such monitoring would allow either increased administration of the compound or the administration of alternative compounds to which the patient has not become resistant.

Furthermore, the SNPs of the present invention may have utility in determining why certain previously developed drugs performed poorly in clinical trials and may help identify a subset of the population that would benefit from a drug that had previously performed poorly in clinical trials, thereby “rescuing” previously developed drugs, and enabling the drug to be made available to a particular patient population (e.g., particular CVD patients) that can benefit from it.

Identification, Screening, and Use of Therapeutic Agents

The SNPs of the present invention also can be used to identify novel therapeutic targets for CVD, particularly CHD, such as MI, or stroke. For example, genes containing the disease-associated variants (“variant genes”) or their products, as well as genes or their products that are directly or indirectly regulated by or interacting with these variant genes or their products, can be targeted for the development of therapeutics that, for example, treat the disease or prevent or delay disease onset. The therapeutics may be composed of, for example, small molecules, proteins, protein fragments or peptides, antibodies, nucleic acids, or their derivatives or mimetics which modulate the functions or levels of the target genes or gene products.

The invention further provides methods for identifying a compound or agent that can be used to treat CVD, particularly CHD such as MI. The SNPs disclosed herein are useful as targets for the identification and/or development of therapeutic agents. A method for identifying a therapeutic agent or compound typically includes assaying the ability of the agent or compound to modulate the activity and/or expression of a SNP-containing nucleic acid or the encoded product and thus identifying an agent or a compound that can be used to treat a disorder characterized by undesired activity or expression of the SNP-containing nucleic acid or the encoded product. The assays can be performed in cell-based and cell-free systems. Cell-based assays can include cells naturally expressing the nucleic acid molecules of interest or recombinant cells genetically engineered to express certain nucleic acid molecules.

Variant gene expression in a CVD patient can include, for example, either expression of a SNP-containing nucleic acid sequence (for instance, a gene that contains a SNP can be transcribed into an mRNA transcript molecule containing the SNP, which can in turn be translated into a variant protein) or altered expression of a normal/wild-type nucleic acid sequence due to one or more SNPs (for instance, a regulatory/control region can contain a SNP that affects the level or pattern of expression of a normal transcript).

Assays for variant gene expression can involve direct assays of nucleic acid levels (e.g., mRNA levels), expressed protein levels, or of collateral compounds involved in a signal pathway. Further, the expression of genes that are up- or down-regulated in response to the signal pathway can also be assayed. In this embodiment, the regulatory regions of these genes can be operably linked to a reporter gene such as luciferase.

Modulators of variant gene expression can be identified in a method wherein, for example, a cell is contacted with a candidate compound/agent and the expression of mRNA determined. The level of expression of mRNA in the presence of the candidate compound is compared to the level of expression of mRNA in the absence of the candidate compound. The candidate compound can then be identified as a modulator of variant gene expression based on this comparison and be used to treat a disorder such as CVD that is characterized by variant gene expression (e.g., either expression of a SNP-containing nucleic acid or altered expression of a normal/wild-type nucleic acid molecule due to one or more SNPs that affect expression of the nucleic acid molecule) due to one or more SNPs of the present invention. When expression of mRNA is statistically significantly greater in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of nucleic acid expression. When nucleic acid expression is statistically significantly less in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of nucleic acid expression.

The invention further provides methods of treatment, with the SNP or associated nucleic acid domain (e.g., catalytic domain, ligand/substrate-binding domain, regulatory/control region, etc.) or gene, or the encoded mRNA transcript, as a target, using a compound identified through drug screening as a gene modulator to modulate variant nucleic acid expression. Modulation can include either up-regulation (i.e., activation or agonization) or down-regulation (i.e., suppression or antagonization) of nucleic acid expression.

Expression of mRNA transcripts and encoded proteins, either wild type or variant, may be altered in individuals with a particular SNP allele in a regulatory/control element, such as a promoter or transcription factor binding domain, that regulates expression. In this situation, methods of treatment and compounds can be identified, as discussed herein, that regulate or overcome the variant regulatory/control element, thereby generating normal, or healthy, expression levels of either the wild type or variant protein.

Pharmaceutical Compositions and Administration Thereof

Any of the statin response-associated proteins, and encoding nucleic acid molecules, disclosed herein can be used as therapeutic targets (or directly used themselves as therapeutic compounds) for treating or preventing CVD, and the present disclosure enables therapeutic compounds (e.g., small molecules, antibodies, therapeutic proteins, RNAi and antisense molecules, etc.) to be developed that target (or are comprised of) any of these therapeutic targets.

In general, a therapeutic compound will be administered in a therapeutically effective amount by any of the accepted modes of administration for agents that serve similar utilities. The actual amount of the therapeutic compound of this invention, i.e., the active ingredient, will depend upon numerous factors such as the severity of the disease to be treated, the age and relative health of the subject, the potency of the compound used, the route and form of administration, and other factors.

Therapeutically effective amounts of therapeutic compounds may range from, for example, approximately 0.01-50 mg per kilogram body weight of the recipient per day; preferably about 0.1-20 mg/kg/day. Thus, as an example, for administration to a 70-kg person, the dosage range would most preferably be about 7 mg to 1.4 g per day.

In general, therapeutic compounds will be administered as pharmaceutical compositions by any one of the following routes: oral, systemic (e.g., transdermal, intranasal, or by suppository), or parenteral (e.g., intramuscular, intravenous, or subcutaneous) administration. The preferred manner of administration is oral or parenteral using a convenient daily dosage regimen, which can be adjusted according to the degree of affliction. Oral compositions can take the form of tablets, pills, capsules, semisolids, powders, sustained release formulations, solutions, suspensions, elixirs, aerosols, or any other appropriate compositions.

The choice of formulation depends on various factors such as the mode of drug administration (e.g., for oral administration, formulations in the form of tablets, pills, or capsules are preferred) and the bioavailability of the drug substance. Recently, pharmaceutical formulations have been developed especially for drugs that show poor bioavailability based upon the principle that bioavailability can be increased by increasing the surface area, i.e., decreasing particle size. For example, U.S. Pat. No. 4,107,288 describes a pharmaceutical formulation having particles in the size range from 10 to 1,000 nm in which the active material is supported on a cross-linked matrix of macromolecules. U.S. Pat. No. 5,145,684 describes the production of a pharmaceutical formulation in which the drug substance is pulverized to nanoparticles (average particle size of 400 nm) in the presence of a surface modifier and then dispersed in a liquid medium to give a pharmaceutical formulation that exhibits remarkably high bioavailability.

Pharmaceutical compositions are comprised of, in general, a therapeutic compound in combination with at least one pharmaceutically acceptable excipient. Acceptable excipients are non-toxic, aid administration, and do not adversely affect the therapeutic benefit of the therapeutic compound. Such excipients may be any solid, liquid, semi-solid or, in the case of an aerosol composition, gaseous excipient that is generally available to one skilled in the art.

Solid pharmaceutical excipients include starch, cellulose, talc, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, magnesium stearate, sodium stearate, glycerol monostearate, sodium chloride, dried skim milk and the like. Liquid and semisolid excipients may be selected from glycerol, propylene glycol, water, ethanol and various oils, including those of petroleum, animal, vegetable or synthetic origin, e.g., peanut oil, soybean oil, mineral oil, sesame oil, etc. Preferred liquid carriers, particularly for injectable solutions, include water, saline, aqueous dextrose, and glycols.

Compressed gases may be used to disperse a compound of this invention in aerosol form. Inert gases suitable for this purpose are nitrogen, carbon dioxide, etc.

Other suitable pharmaceutical excipients and their formulations are described in Remington's Pharmaceutical Sciences 18^(th) ed., E. W. Martin, ed., Mack Publishing Company (1990).

The amount of the therapeutic compound in a formulation can vary within the full range employed by those skilled in the art. Typically, the formulation will contain, on a weight percent (wt %) basis, from about 0.01-99.99 wt % of the therapeutic compound based on the total formulation, with the balance being one or more suitable pharmaceutical excipients. Preferably, the compound is present at a level of about 1-80% wt.

Therapeutic compounds can be administered alone or in combination with other therapeutic compounds or in combination with one or more other active ingredient(s). For example, an inhibitor or stimulator of a CVD-associated protein can be administered in combination with another agent that inhibits or stimulates the activity of the same or a different CVD-associated protein to thereby counteract the effects of CVD.

For further information regarding pharmacology, see Current Protocols in Pharmacology, John Wiley & Sons, Inc., N.Y.

Nucleic Acid-Based Therapeutic Agents

The SNP-containing nucleic acid molecules disclosed herein, and their complementary nucleic acid molecules, may be used as antisense constructs to control gene expression in cells, tissues, and organisms. Antisense technology is well established in the art and extensively reviewed in Antisense Drug Technology: Principles, Strategies, and Applications, Crooke, ed., Marcel Dekker, Inc., N.Y. (2001). An antisense nucleic acid molecule is generally designed to be complementary to a region of mRNA expressed by a gene so that the antisense molecule hybridizes to the mRNA and thereby blocks translation of mRNA into protein. Various classes of antisense oligonucleotides are used in the art, two of which are cleavers and blockers. Cleavers, by binding to target RNAs, activate intracellular nucleases (e.g., RNaseH or RNase L) that cleave the target RNA. Blockers, which also bind to target RNAs, inhibit protein translation through steric hindrance of ribosomes. Exemplary blockers include peptide nucleic acids, morpholinos, locked nucleic acids, and methylphosphonates. See, e.g., Thompson, Drug Discovery Today 7(17): 912-917 (2002). Antisense oligonucleotides are directly useful as therapeutic agents, and are also useful for determining and validating gene function (e.g., in gene knock-out or knock-down experiments).

Antisense technology is further reviewed in: Lavery et al., “Antisense and RNAi: powerful tools in drug target discovery and validation,” Curr Opin Drug Discov Devel 6(4):561-9 (July 2003); Stephens et al., “Antisense oligonucleotide therapy in cancer,” Curr Opin Mol Ther 5(2):118-22 (April 2003); Kurreck, “Antisense technologies. Improvement through novel chemical modifications,” Eur J Biochem 270(8):1628-44 (April 2003); Dias et al., “Antisense oligonucleotides: basic concepts and mechanisms,” Mol Cancer Ther 1(5):347-55 (March 2002); Chen, “Clinical development of antisense oligonucleotides as anti-cancer therapeutics,” Methods Mol Med 75:621-36 (2003); Wang et al., “Antisense anticancer oligonucleotide therapeutics,” Curr Cancer Drug Targets 1(3):177-96 (November 2001); and Bennett, “Efficiency of antisense oligonucleotide drug discovery,” Antisense Nucleic Acid Drug Dev 12(3):215-24 (June 2002).

The SNPs of the present invention are particularly useful for designing antisense reagents that are specific for particular nucleic acid variants. Based on the SNP information disclosed herein, antisense oligonucleotides can be produced that specifically target mRNA molecules that contain one or more particular SNP nucleotides. In this manner, expression of mRNA molecules that contain one or more undesired polymorphisms (e.g., SNP nucleotides that lead to a defective protein such as an amino acid substitution in a catalytic domain) can be inhibited or completely blocked. Thus, antisense oligonucleotides can be used to specifically bind a particular polymorphic form (e.g., a SNP allele that encodes a defective protein), thereby inhibiting translation of this form, but which do not bind an alternative polymorphic form (e.g., an alternative SNP nucleotide that encodes a protein having normal function).

Antisense molecules can be used to inactivate mRNA in order to inhibit gene expression and production of defective proteins. Accordingly, these molecules can be used to treat a disorder, such as CVD, characterized by abnormal or undesired gene expression or expression of certain defective proteins. This technique can involve cleavage by means of ribozymes containing nucleotide sequences complementary to one or more regions in the mRNA that attenuate the ability of the mRNA to be translated. Possible mRNA regions include, for example, protein-coding regions and particularly protein-coding regions corresponding to catalytic activities, substrate/ligand binding, or other functional activities of a protein.

The SNPs of the present invention are also useful for designing RNA interference reagents that specifically target nucleic acid molecules having particular SNP variants. RNA interference (RNAi), also referred to as gene silencing, is based on using double-stranded RNA (dsRNA) molecules to turn genes off. When introduced into a cell, dsRNAs are processed by the cell into short fragments (generally about 21, 22, or 23 nucleotides in length) known as small interfering RNAs (siRNAs) which the cell uses in a sequence-specific manner to recognize and destroy complementary RNAs. Thompson, Drug Discovery Today 7(17): 912-917 (2002). Accordingly, an aspect of the present invention specifically contemplates isolated nucleic acid molecules that are about 18-26 nucleotides in length, preferably 19-25 nucleotides in length, and more preferably 20, 21, 22, or 23 nucleotides in length, and the use of these nucleic acid molecules for RNAi. Because RNAi molecules, including siRNAs, act in a sequence-specific manner, the SNPs of the present invention can be used to design RNAi reagents that recognize and destroy nucleic acid molecules having specific SNP alleles/nucleotides (such as deleterious alleles that lead to the production of defective proteins), while not affecting nucleic acid molecules having alternative SNP alleles (such as alleles that encode proteins having normal function). As with antisense reagents, RNAi reagents may be directly useful as therapeutic agents (e.g., for turning off defective, disease-causing genes), and are also useful for characterizing and validating gene function (e.g., in gene knock-out or knock-down experiments).

The following references provide a further review of RNAi: Reynolds et al., “Rational siRNA design for RNA interference,” Nat Biotechnol 22(3):326-30 (March 2004); Epub Feb. 1, 2004; Chi et al., “Genomewide view of gene silencing by small interfering RNAs,” PNAS 100(11):6343-6346 (2003); Vickers et al., “Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents,” J Biol Chem 278:7108-7118 (2003); Agami, “RNAi and related mechanisms and their potential use for therapy,” Curr Opin Chem Biol 6(6):829-34 (December 2002); Lavery et al., “Antisense and RNAi: powerful tools in drug target discovery and validation,” Curr Opin Drug Discov Devel 6(4):561-9 (July 2003); Shi, “Mammalian RNAi for the masses,” Trends Genet 19(1):9-12 (January 2003); Shuey et al., “RNAi: gene-silencing in therapeutic intervention,” Drug Discovery Today 7(20):1040-1046 (October 2002); McManus et al., Nat Rev Genet 3(10):737-47 (October 2002); Xia et al., Nat Biotechnol 20(10):1006-10 (October 2002); Plasterk et al., Curr Opin Genet Dev 10(5):562-7 (October 2000); Bosher et al., Nat Cell Biol 2(2):E31-6 (February 2000); and Hunter, Curr Biol 17; 9(12):R440-2 (June 1999).

Other Therapeutic Aspects

SNPs have many important uses in drug discovery, screening, and development, and thus the SNPs of the present invention are useful for improving many different aspects of the drug development process.

For example, a high probability exists that, for any gene/protein selected as a potential drug target, variants of that gene/protein will exist in a patient population. Thus, determining the impact of gene/protein variants on the selection and delivery of a therapeutic agent should be an integral aspect of the drug discovery and development process. Jazwinska, A Trends Guide to Genetic Variation and Genomic Medicine S30-S36 (March 2002).

Knowledge of variants (e.g., SNPs and any corresponding amino acid polymorphisms) of a particular therapeutic target (e.g., a gene, mRNA transcript, or protein) enables parallel screening of the variants in order to identify therapeutic candidates (e.g., small molecule compounds, antibodies, antisense or RNAi nucleic acid compounds, etc.) that demonstrate efficacy across variants. Rothberg, Nat Biotechnol 19(3):209-11 (March 2001). Such therapeutic candidates would be expected to show equal efficacy across a larger segment of the patient population, thereby leading to a larger potential market for the therapeutic candidate.

Furthermore, identifying variants of a potential therapeutic target enables the most common form of the target to be used for selection of therapeutic candidates, thereby helping to ensure that the experimental activity that is observed for the selected candidates reflects the real activity expected in the largest proportion of a patient population. Jazwinska, A Trends Guide to Genetic Variation and Genomic Medicine S30-S36 (March 2002).

Additionally, screening therapeutic candidates against all known variants of a target can enable the early identification of potential toxicities and adverse reactions relating to particular variants. For example, variability in drug absorption, distribution, metabolism and excretion (ADME) caused by, for example, SNPs in therapeutic targets or drug metabolizing genes, can be identified, and this information can be utilized during the drug development process to minimize variability in drug disposition and develop therapeutic agents that are safer across a wider range of a patient population. The SNPs of the present invention, including the variant proteins and encoding polymorphic nucleic acid molecules provided in Tables 1 and 2, are useful in conjunction with a variety of toxicology methods established in the art, such as those set forth in Current Protocols in Toxicology, John Wiley & Sons, Inc., N.Y.

Furthermore, therapeutic agents that target any art-known proteins (or nucleic acid molecules, either RNA or DNA) may cross-react with the variant proteins (or polymorphic nucleic acid molecules) disclosed in Table 1, thereby significantly affecting the pharmacokinetic properties of the drug. Consequently, the protein variants and the SNP-containing nucleic acid molecules disclosed in Tables 1 and 2 are useful in developing, screening, and evaluating therapeutic agents that target corresponding art-known protein forms (or nucleic acid molecules). Additionally, as discussed above, knowledge of all polymorphic forms of a particular drug target enables the design of therapeutic agents that are effective against most or all such polymorphic forms of the drug target.

A subject suffering from a pathological condition ascribed to a SNP, such as CVD, may be treated so as to correct the genetic defect. See Kren et al., Proc Natl Acad Sci USA 96:10349-10354 (1999). Such a subject can be identified by any method that can detect the polymorphism in a biological sample drawn from the subject. Such a genetic defect may be permanently corrected by administering to such a subject a nucleic acid fragment incorporating a repair sequence that supplies the normal/wild-type nucleotide at the position of the SNP. This site-specific repair sequence can encompass an RNA/DNA oligonucleotide that operates to promote endogenous repair of a subject's genomic DNA. The site-specific repair sequence is administered in an appropriate vehicle, such as a complex with polyethylenimine, encapsulated in anionic liposomes, a viral vector such as an adenovirus, or other pharmaceutical composition that promotes intracellular uptake of the administered nucleic acid. A genetic defect leading to an inborn pathology may then be overcome, as the chimeric oligonucleotides induce incorporation of the normal sequence into the subject's genome. Upon incorporation, the normal gene product is expressed, and the replacement is propagated, thereby engendering a permanent repair and therapeutic enhancement of the clinical condition of the subject.

In cases in which a cSNP results in a variant protein that is ascribed to be the cause of, or a contributing factor to, a pathological condition, a method of treating such a condition can include administering to a subject experiencing the pathology the wild-type/normal cognate of the variant protein. Once administered in an effective dosing regimen, the wild-type cognate provides complementation or remediation of the pathological condition.

Variant Proteins, Antibodies, Vectors, Host Cells, & Uses Thereof

Variant Proteins Encoded by SNP-Containing Nucleic Acid Molecules

The present invention provides SNP-containing nucleic acid molecules, many of which encode proteins having variant amino acid sequences as compared to the art-known (i.e., wild-type) proteins. Amino acid sequences encoded by the polymorphic nucleic acid molecules of the present invention are referred to as SEQ ID NOS: 52-102 in Table 1 and provided in the Sequence Listing. These variants will generally be referred to herein as variant proteins/peptides/polypeptides, or polymorphic proteins/peptides/polypeptides of the present invention. The terms “protein,” “peptide,” and “polypeptide” are used herein interchangeably.

A variant protein of the present invention may be encoded by, for example, a nonsynonymous nucleotide substitution at any one of the cSNP positions disclosed herein. In addition, variant proteins may also include proteins whose expression, structure, and/or function is altered by a SNP disclosed herein, such as a SNP that creates or destroys a stop codon, a SNP that affects splicing, and a SNP in control/regulatory elements, e.g. promoters, enhancers, or transcription factor binding domains.

As used herein, a protein or peptide is said to be “isolated” or “purified” when it is substantially free of cellular material or chemical precursors or other chemicals. The variant proteins of the present invention can be purified to homogeneity or other lower degrees of purity. The level of purification will be based on the intended use. The key feature is that the preparation allows for the desired function of the variant protein, even if in the presence of considerable amounts of other components.

As used herein, “substantially free of cellular material” includes preparations of the variant protein having less than about 30% (by dry weight) other proteins (i.e., contaminating protein), less than about 20% other proteins, less than about 10% other proteins, or less than about 5% other proteins. When the variant protein is recombinantly produced, it can also be substantially free of culture medium, i.e., culture medium represents less than about 20% of the volume of the protein preparation.

The language “substantially free of chemical precursors or other chemicals” includes preparations of the variant protein in which it is separated from chemical precursors or other chemicals that are involved in its synthesis. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of the variant protein having less than about 30% (by dry weight) chemical precursors or other chemicals, less than about 20% chemical precursors or other chemicals, less than about 10% chemical precursors or other chemicals, or less than about 5% chemical precursors or other chemicals.

An isolated variant protein may be purified from cells that naturally express it, purified from cells that have been altered to express it (recombinant host cells), or synthesized using known protein synthesis methods. For example, a nucleic acid molecule containing SNP(s) encoding the variant protein can be cloned into an expression vector, the expression vector introduced into a host cell, and the variant protein expressed in the host cell. The variant protein can then be isolated from the cells by any appropriate purification scheme using standard protein purification techniques. Examples of these techniques are described in detail below. Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, N.Y. (2000).

The present invention provides isolated variant proteins that comprise, consist of or consist essentially of amino acid sequences that contain one or more variant amino acids encoded by one or more codons that contain a SNP of the present invention.

Accordingly, the present invention provides variant proteins that consist of amino acid sequences that contain one or more amino acid polymorphisms (or truncations or extensions due to creation or destruction of a stop codon, respectively) encoded by the SNPs provided in Table 1 and/or Table 2. A protein consists of an amino acid sequence when the amino acid sequence is the entire amino acid sequence of the protein.

The present invention further provides variant proteins that consist essentially of amino acid sequences that contain one or more amino acid polymorphisms (or truncations or extensions due to creation or destruction of a stop codon, respectively) encoded by the SNPs provided in Table 1 and/or Table 2. A protein consists essentially of an amino acid sequence when such an amino acid sequence is present with only a few additional amino acid residues in the final protein.

The present invention further provides variant proteins that comprise amino acid sequences that contain one or more amino acid polymorphisms (or truncations or extensions due to creation or destruction of a stop codon, respectively) encoded by the SNPs provided in Table 1 and/or Table 2. A protein comprises an amino acid sequence when the amino acid sequence is at least part of the final amino acid sequence of the protein. In such a fashion, the protein may contain only the variant amino acid sequence or have additional amino acid residues, such as a contiguous encoded sequence that is naturally associated with it or heterologous amino acid residues. Such a protein can have a few additional amino acid residues or can comprise many more additional amino acids. A brief description of how various types of these proteins can be made and isolated is provided below.

The variant proteins of the present invention can be attached to heterologous sequences to form chimeric or fusion proteins. Such chimeric and fusion proteins comprise a variant protein operatively linked to a heterologous protein having an amino acid sequence not substantially homologous to the variant protein. “Operatively linked” indicates that the coding sequences for the variant protein and the heterologous protein are ligated in-frame. The heterologous protein can be fused to the N-terminus or C-terminus of the variant protein. In another embodiment, the fusion protein is encoded by a fusion polynucleotide that is synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and re-amplified to generate a chimeric gene sequence. See Ausubel et al., Current Protocols in Molecular Biology (1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST protein). A variant protein-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the variant protein.

In many uses, the fusion protein does not affect the activity of the variant protein. The fusion protein can include, but is not limited to, enzymatic fusion proteins, for example, beta-galactosidase fusions, yeast two-hybrid GAL fusions, poly-His fusions, MYC-tagged, HI-tagged and Ig fusions. Such fusion proteins, particularly poly-His fusions, can facilitate their purification following recombinant expression. In certain host cells (e.g., mammalian host cells), expression and/or secretion of a protein can be increased by using a heterologous signal sequence. Fusion proteins are further described in, for example, Terpe, “Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems,” Appl Microbiol Biotechnol 60(5):523-33 (January 2003); Epub Nov. 7, 2002; Graddis et al., “Designing proteins that work using recombinant technologies,” Curr Pharm Biotechnol 3(4):285-97 (December 2002); and Nilsson et al., “Affinity fusion strategies for detection, purification, and immobilization of recombinant proteins,” Protein Expr Purif 11(1):1-16 (October 1997).

In certain embodiments, novel compositions of the present invention also relate to further obvious variants of the variant polypeptides of the present invention, such as naturally-occurring mature forms (e.g., allelic variants), non-naturally occurring recombinantly-derived variants, and orthologs and paralogs of such proteins that share sequence homology. Such variants can readily be generated using art-known techniques in the fields of recombinant nucleic acid technology and protein biochemistry.

Further variants of the variant polypeptides disclosed in Table 1 can comprise an amino acid sequence that shares at least 70-80%, 80-85%, 85-90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity with an amino acid sequence disclosed in Table 1 (or a fragment thereof) and that includes a novel amino acid residue (allele) disclosed in Table 1 (which is encoded by a novel SNP allele). Thus, an aspect of the present invention that is specifically contemplated are polypeptides that have a certain degree of sequence variation compared with the polypeptide sequences shown in Table 1, but that contain a novel amino acid residue (allele) encoded by a novel SNP allele disclosed herein. In other words, as long as a polypeptide contains a novel amino acid residue disclosed herein, other portions of the polypeptide that flank the novel amino acid residue can vary to some degree from the polypeptide sequences shown in Table 1.

Full-length pre-processed forms, as well as mature processed forms, of proteins that comprise one of the amino acid sequences disclosed herein can readily be identified as having complete sequence identity to one of the variant proteins of the present invention as well as being encoded by the same genetic locus as the variant proteins provided herein.

Orthologs of a variant peptide can readily be identified as having some degree of significant sequence homology/identity to at least a portion of a variant peptide as well as being encoded by a gene from another organism. Preferred orthologs will be isolated from non-human mammals, preferably primates, for the development of human therapeutic targets and agents. Such orthologs can be encoded by a nucleic acid sequence that hybridizes to a variant peptide-encoding nucleic acid molecule under moderate to stringent conditions depending on the degree of relatedness of the two organisms yielding the homologous proteins.

Variant proteins include, but are not limited to, proteins containing deletions, additions and substitutions in the amino acid sequence caused by the SNPs of the present invention. One class of substitutions is conserved amino acid substitutions in which a given amino acid in a polypeptide is substituted for another amino acid of like characteristics. Typical conservative substitutions are replacements, one for another, among the aliphatic amino acids Ala, Val, Leu, and Ile; interchange of the hydroxyl residues Ser and Thr; exchange of the acidic residues Asp and Glu; substitution between the amide residues Asn and Gln; exchange of the basic residues Lys and Arg; and replacements among the aromatic residues Phe and Tyr. Guidance concerning which amino acid changes are likely to be phenotypically silent are found, for example, in Bowie et al., Science 247:1306-1310 (1990).

Variant proteins can be fully functional or can lack function in one or more activities, e.g. ability to bind another molecule, ability to catalyze a substrate, ability to mediate signaling, etc. Fully functional variants typically contain only conservative variations or variations in non-critical residues or in non-critical regions. Functional variants can also contain substitution of similar amino acids that result in no change or an insignificant change in function. Alternatively, such substitutions may positively or negatively affect function to some degree. Non-functional variants typically contain one or more non-conservative amino acid substitutions, deletions, insertions, inversions, truncations or extensions, or a substitution, insertion, inversion, or deletion of a critical residue or in a critical region.

Amino acids that are essential for function of a protein can be identified by methods known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis, particularly using the amino acid sequence and polymorphism information provided in Table 1. Cunningham et al., Science 244:1081-1085 (1989). The latter procedure introduces single alanine mutations at every residue in the molecule. The resulting mutant molecules are then tested for biological activity such as enzyme activity or in assays such as an in vitro proliferative activity. Sites that are critical for binding partner/substrate binding can also be determined by structural analysis such as crystallization, nuclear magnetic resonance or photoaffinity labeling. Smith et al., J Mol Biol 224:899-904 (1992); de Vos et al., Science 255:306-312 (1992).

Polypeptides can contain amino acids other than the 20 amino acids commonly referred to as the 20 naturally occurring amino acids. Further, many amino acids, including the terminal amino acids, may be modified by natural processes, such as processing and other post-translational modifications, or by chemical modification techniques well known in the art. Accordingly, the variant proteins of the present invention also encompass derivatives or analogs in which a substituted amino acid residue is not one encoded by the genetic code, in which a substituent group is included, in which the mature polypeptide is fused with another compound, such as a compound to increase the half-life of the polypeptide (e.g., polyethylene glycol), or in which additional amino acids are fused to the mature polypeptide, such as a leader or secretory sequence or a sequence for purification of the mature polypeptide or a pro-protein sequence.

Known protein modifications include, but are not limited to, acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent crosslinks, formation of cystine, formation of pyroglutamate, formylation, gamma carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination.

Such protein modifications are well known to those of skill in the art and have been described in great detail in the scientific literature. Particularly common modifications, for example glycosylation, lipid attachment, sulfation, gamma-carboxylation of glutamic acid residues, hydroxylation and ADP-ribosylation, are described in most basic texts, such as Proteins—Structure and Molecular Properties 2nd Ed., T. E. Creighton, W. H. Freeman and Company, N.Y. (1993); F. Wold, Posttranslational Covalent Modification of Proteins 1-12, B. C. Johnson, ed., Academic Press, N.Y. (1983); Seifter et al., Meth Enzymol 182:626-646 (1990); and Rattan et al., Ann NY Acad Sci 663:48-62 (1992).

The present invention further provides fragments of the variant proteins in which the fragments contain one or more amino acid sequence variations (e.g., substitutions, or truncations or extensions due to creation or destruction of a stop codon) encoded by one or more SNPs disclosed herein. The fragments to which the invention pertains, however, are not to be construed as encompassing fragments that have been disclosed in the prior art before the present invention.

As used herein, a fragment may comprise at least about 4, 8, 10, 12, 14, 16, 18, 20, 25, 30, 50, 100 (or any other number in-between) or more contiguous amino acid residues from a variant protein, wherein at least one amino acid residue is affected by a SNP of the present invention, e.g., a variant amino acid residue encoded by a nonsynonymous nucleotide substitution at a cSNP position provided by the present invention. The variant amino acid encoded by a cSNP may occupy any residue position along the sequence of the fragment. Such fragments can be chosen based on the ability to retain one or more of the biological activities of the variant protein or the ability to perform a function, e.g., act as an immunogen. Particularly important fragments are biologically active fragments. Such fragments will typically comprise a domain or motif of a variant protein of the present invention, e.g., active site, transmembrane domain, or ligand/substrate binding domain. Other fragments include, but are not limited to, domain or motif-containing fragments, soluble peptide fragments, and fragments containing immunogenic structures. Predicted domains and functional sites are readily identifiable by computer programs well known to those of skill in the art (e.g., PROSITE analysis). Current Protocols in Protein Science, John Wiley & Sons, N.Y. (2002).

Uses of Variant Proteins

The variant proteins of the present invention can be used in a variety of ways, including but not limited to, in assays to determine the biological activity of a variant protein, such as in a panel of multiple proteins for high-throughput screening; to raise antibodies or to elicit another type of immune response; as a reagent (including the labeled reagent) in assays designed to quantitatively determine levels of the variant protein (or its binding partner) in biological fluids; as a marker for cells or tissues in which it is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in a disease state); as a target for screening for a therapeutic agent; and as a direct therapeutic agent to be administered into a human subject. Any of the variant proteins disclosed herein may be developed into reagent grade or kit format for commercialization as research products. Methods for performing the uses listed above are well known to those skilled in the art. See, e.g., Molecular Cloning: A Laboratory Manual, Sambrook and Russell, Cold Spring Harbor Laboratory Press, N.Y. (2000), and Methods in Enzymology: Guide to Molecular Cloning Techniques, S. L. Berger and A. R. Kimmel, eds., Academic Press (1987).

In a specific embodiment of the invention, the methods of the present invention include detection of one or more variant proteins disclosed herein. Variant proteins are disclosed in Table 1 and in the Sequence Listing as SEQ ID NOS: 52-102. Detection of such proteins can be accomplished using, for example, antibodies, small molecule compounds, aptamers, ligands/substrates, other proteins or protein fragments, or other protein-binding agents. Preferably, protein detection agents are specific for a variant protein of the present invention and can therefore discriminate between a variant protein of the present invention and the wild-type protein or another variant form. This can generally be accomplished by, for example, selecting or designing detection agents that bind to the region of a protein that differs between the variant and wild-type protein, such as a region of a protein that contains one or more amino acid substitutions that is/are encoded by a non-synonymous cSNP of the present invention, or a region of a protein that follows a nonsense mutation-type SNP that creates a stop codon thereby leading to a shorter polypeptide, or a region of a protein that follows a read-through mutation-type SNP that destroys a stop codon thereby leading to a longer polypeptide in which a portion of the polypeptide is present in one version of the polypeptide but not the other.

In another aspect of the invention, variant proteins of the present invention can be used as targets for predicting an individual's response to statin treatment (particularly for reducing the risk of CVD, especially CHD such as MI), for determining predisposition to CVD (particularly CHD, such as MI), for diagnosing CVD, or for treating and/or preventing CVD, etc. Accordingly, the invention provides methods for detecting the presence of, or levels of, one or more variant proteins of the present invention in a cell, tissue, or organism. Such methods typically involve contacting a test sample with an agent (e.g., an antibody, small molecule compound, or peptide) capable of interacting with the variant protein such that specific binding of the agent to the variant protein can be detected. Such an assay can be provided in a single detection format or a multi-detection format such as an array, for example, an antibody or aptamer array (arrays for protein detection may also be referred to as “protein chips”). The variant protein of interest can be isolated from a test sample and assayed for the presence of a variant amino acid sequence encoded by one or more SNPs disclosed by the present invention. The SNPs may cause changes to the protein and the corresponding protein function/activity, such as through non-synonymous substitutions in protein coding regions that can lead to amino acid substitutions, deletions, insertions, and/or rearrangements; formation or destruction of stop codons; or alteration of control elements such as promoters. SNPs may also cause inappropriate post-translational modifications.

One preferred agent for detecting a variant protein in a sample is an antibody capable of selectively binding to a variant form of the protein (antibodies are described in greater detail in the next section). Such samples include, for example, tissues, cells, and biological fluids isolated from a subject, as well as tissues, cells and fluids present within a subject.

In vitro methods for detection of the variant proteins associated with statin response that are disclosed herein and fragments thereof include, but are not limited to, enzyme linked immunosorbent assays (ELISAs), radioimmunoassays (RIA), Western blots, immunoprecipitations, immunofluorescence, and protein arrays/chips (e.g., arrays of antibodies or aptamers). For further information regarding immunoassays and related protein detection methods, see Current Protocols in Immunology, John Wiley & Sons, N.Y., and Hage, “Immunoassays,” Anal Chem 15; 71(12):294R-304R (June 1999).

Additional analytic methods of detecting amino acid variants include, but are not limited to, altered electrophoretic mobility, altered tryptic peptide digest, altered protein activity in cell-based or cell-free assay, alteration in ligand or antibody-binding pattern, altered isoelectric point, and direct amino acid sequencing.

Alternatively, variant proteins can be detected in vivo in a subject by introducing into the subject a labeled antibody (or other type of detection reagent) specific for a variant protein. For example, the antibody can be labeled with a radioactive marker whose presence and location in a subject can be detected by standard imaging techniques.

Other uses of the variant peptides of the present invention are based on the class or action of the protein. For example, proteins isolated from humans and their mammalian orthologs serve as targets for identifying agents (e.g., small molecule drugs or antibodies) for use in therapeutic applications, particularly for modulating a biological or pathological response in a cell or tissue that expresses the protein. Pharmaceutical agents can be developed that modulate protein activity.

As an alternative to modulating gene expression, therapeutic compounds can be developed that modulate protein function. For example, many SNPs disclosed herein affect the amino acid sequence of the encoded protein (e.g., non-synonymous cSNPs and nonsense mutation-type SNPs). Such alterations in the encoded amino acid sequence may affect protein function, particularly if such amino acid sequence variations occur in functional protein domains, such as catalytic domains, ATP-binding domains, or ligand/substrate binding domains. It is well established in the art that variant proteins having amino acid sequence variations in functional domains can cause or influence pathological conditions. In such instances, compounds (e.g., small molecule drugs or antibodies) can be developed that target the variant protein and modulate (e.g., up- or down-regulate) protein function/activity.

The therapeutic methods of the present invention further include methods that target one or more variant proteins of the present invention. Variant proteins can be targeted using, for example, small molecule compounds, antibodies, aptamers, ligands/substrates, other proteins, or other protein-binding agents. Additionally, the skilled artisan will recognize that the novel protein variants (and polymorphic nucleic acid molecules) disclosed in Table 1 may themselves be directly used as therapeutic agents by acting as competitive inhibitors of corresponding art-known proteins (or nucleic acid molecules such as mRNA molecules).

The variant proteins of the present invention are particularly useful in drug screening assays, in cell-based or cell-free systems. Cell-based systems can utilize cells that naturally express the protein, a biopsy specimen, or cell cultures. In one embodiment, cell-based assays involve recombinant host cells expressing the variant protein. Cell-free assays can be used to detect the ability of a compound to directly bind to a variant protein or to the corresponding SNP-containing nucleic acid fragment that encodes the variant protein.

A variant protein of the present invention, as well as appropriate fragments thereof, can be used in high-throughput screening assays to test candidate compounds for the ability to bind and/or modulate the activity of the variant protein. These candidate compounds can be further screened against a protein having normal function (e.g., a wild-type/non-variant protein) to further determine the effect of the compound on the protein activity. Furthermore, these compounds can be tested in animal or invertebrate systems to determine in vivo activity/effectiveness. Compounds can be identified that activate (agonists) or inactivate (antagonists) the variant protein, and different compounds can be identified that cause various degrees of activation or inactivation of the variant protein.

Further, the variant proteins can be used to screen a compound for the ability to stimulate or inhibit interaction between the variant protein and a target molecule that normally interacts with the protein. The target can be a ligand, a substrate or a binding partner that the protein normally interacts with (for example, epinephrine or norepinephrine). Such assays typically include the steps of combining the variant protein with a candidate compound under conditions that allow the variant protein, or fragment thereof, to interact with the target molecule, and to detect the formation of a complex between the protein and the target or to detect the biochemical consequence of the interaction with the variant protein and the target, such as any of the associated effects of signal transduction.

Candidate compounds include, for example, 1) peptides such as soluble peptides, including Ig-tailed fusion peptides and members of random peptide libraries (see, e.g., Lam et al., Nature 354:82-84 (1991); Houghten et al., Nature 354:84-86 (1991)) and combinatorial chemistry-derived molecular libraries made of D- and/or L-configuration amino acids; 2) phosphopeptides (e.g., members of random and partially degenerate, directed phosphopeptide libraries, see, e.g., Songyang et al., Cell 72:767-778 (1993)); 3) antibodies (e.g., polyclonal, monoclonal, humanized, anti-idiotypic, chimeric, and single chain antibodies as well as Fab, F(ab′)₂, Fab expression library fragments, and epitope-binding fragments of antibodies); and 4) small organic and inorganic molecules (e.g., molecules obtained from combinatorial and natural product libraries).

One candidate compound is a soluble fragment of the variant protein that competes for ligand binding. Other candidate compounds include mutant proteins or appropriate fragments containing mutations that affect variant protein function and thus compete for ligand. Accordingly, a fragment that competes for ligand, for example with a higher affinity, or a fragment that binds ligand but does not allow release, is encompassed by the invention.

The invention further includes other end point assays to identify compounds that modulate (stimulate or inhibit) variant protein activity. The assays typically involve an assay of events in the signal transduction pathway that indicate protein activity. Thus, the expression of genes that are up or down-regulated in response to the variant protein dependent signal cascade can be assayed. In one embodiment, the regulatory region of such genes can be operably linked to a marker that is easily detectable, such as luciferase. Alternatively, phosphorylation of the variant protein, or a variant protein target, could also be measured. Any of the biological or biochemical functions mediated by the variant protein can be used as an endpoint assay. These include all of the biochemical or biological events described herein, in the references cited herein, incorporated by reference for these endpoint assay targets, and other functions known to those of ordinary skill in the art.

Binding and/or activating compounds can also be screened by using chimeric variant proteins in which an amino terminal extracellular domain or parts thereof, an entire transmembrane domain or subregions, and/or the carboxyl terminal intracellular domain or parts thereof, can be replaced by heterologous domains or subregions. For example, a substrate-binding region can be used that interacts with a different substrate than that which is normally recognized by a variant protein. Accordingly, a different set of signal transduction components is available as an end-point assay for activation. This allows for assays to be performed in other than the specific host cell from which the variant protein is derived.

The variant proteins are also useful in competition binding assays in methods designed to discover compounds that interact with the variant protein. Thus, a compound can be exposed to a variant protein under conditions that allow the compound to bind or to otherwise interact with the variant protein. A binding partner, such as ligand, that normally interacts with the variant protein is also added to the mixture. If the test compound interacts with the variant protein or its binding partner, it decreases the amount of complex formed or activity from the variant protein. This type of assay is particularly useful in screening for compounds that interact with specific regions of the variant protein. Hodgson, Bio/technology, 10(9), 973-80 (September 1992).

To perform cell-free drug screening assays, it is sometimes desirable to immobilize either the variant protein or a fragment thereof, or its target molecule, to facilitate separation of complexes from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay. Any method for immobilizing proteins on matrices can be used in drug screening assays. In one embodiment, a fusion protein containing an added domain allows the protein to be bound to a matrix. For example, glutathione-S-transferase/¹²⁵I fusion proteins can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, Mo.) or glutathione derivatized microtitre plates, which are then combined with the cell lysates (e.g., ³⁵S-labeled) and a candidate compound, such as a drug candidate, and the mixture incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads can be washed to remove any unbound label, and the matrix immobilized and radiolabel determined directly, or in the supernatant after the complexes are dissociated. Alternatively, the complexes can be dissociated from the matrix, separated by SDS-PAGE, and the level of bound material found in the bead fraction quantitated from the gel using standard electrophoretic techniques.

Either the variant protein or its target molecule can be immobilized utilizing conjugation of biotin and streptavidin. Alternatively, antibodies reactive with the variant protein but which do not interfere with binding of the variant protein to its target molecule can be derivatized to the wells of the plate, and the variant protein trapped in the wells by antibody conjugation. Preparations of the target molecule and a candidate compound are incubated in the variant protein-presenting wells and the amount of complex trapped in the well can be quantitated. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the protein target molecule, or which are reactive with variant protein and compete with the target molecule, and enzyme-linked assays that rely on detecting an enzymatic activity associated with the target molecule.

Modulators of variant protein activity identified according to these drug screening assays can be used to treat a subject with a disorder mediated by the protein pathway, such as CVD. These methods of treatment typically include the steps of administering the modulators of protein activity in a pharmaceutical composition to a subject in need of such treatment.

The variant proteins, or fragments thereof, disclosed herein can themselves be directly used to treat a disorder characterized by an absence of, inappropriate, or unwanted expression or activity of the variant protein. Accordingly, methods for treatment include the use of a variant protein disclosed herein or fragments thereof.

In yet another aspect of the invention, variant proteins can be used as “bait proteins” in a two-hybrid assay or three-hybrid assay to identify other proteins that bind to or interact with the variant protein and are involved in variant protein activity. See, e.g., U.S. Pat. No. 5,283,317; Zervos et al., Cell 72:223-232 (1993); Madura et al., J Biol Chem 268:12046-12054 (1993); Bartel et al., Biotechniques 14:920-924 (1993); Iwabuchi et al., Oncogene 8:1693-1696 (1993); and Brent, WO 94/10300. Such variant protein-binding proteins are also likely to be involved in the propagation of signals by the variant proteins or variant protein targets as, for example, elements of a protein-mediated signaling pathway. Alternatively, such variant protein-binding proteins are inhibitors of the variant protein.

The two-hybrid system is based on the modular nature of most transcription factors, which typically consist of separable DNA-binding and activation domains. Briefly, the assay typically utilizes two different DNA constructs. In one construct, the gene that codes for a variant protein is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified protein (“prey” or “sample”) is fused to a gene that codes for the activation domain of the known transcription factor. If the “bait” and the “prey” proteins are able to interact, in vivo, forming a variant protein-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) that is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected, and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene that encodes the protein that interacts with the variant protein.

Antibodies Directed to Variant Proteins

The present invention also provides antibodies that selectively bind to the variant proteins disclosed herein and fragments thereof. Such antibodies may be used to quantitatively or qualitatively detect the variant proteins of the present invention. As used herein, an antibody selectively binds a target variant protein when it binds the variant protein and does not significantly bind to non-variant proteins, i.e., the antibody does not significantly bind to normal, wild-type, or art-known proteins that do not contain a variant amino acid sequence due to one or more SNPs of the present invention (variant amino acid sequences may be due to, for example, nonsynonymous cSNPs, nonsense SNPs that create a stop codon, thereby causing a truncation of a polypeptide or SNPs that cause read-through mutations resulting in an extension of a polypeptide).

As used herein, an antibody is defined in terms consistent with that recognized in the art: they are multi-subunit proteins produced by an organism in response to an antigen challenge. The antibodies of the present invention include both monoclonal antibodies and polyclonal antibodies, as well as antigen-reactive proteolytic fragments of such antibodies, such as Fab, F(ab)′₂, and Fv fragments. In addition, an antibody of the present invention further includes any of a variety of engineered antigen-binding molecules such as a chimeric antibody (U.S. Pat. Nos. 4,816,567 and 4,816,397; Morrison et al., Proc Natl Acad Sci USA 81:6851 (1984); Neuberger et al., Nature 312:604 (1984)), a humanized antibody (U.S. Pat. Nos. 5,693,762; 5,585,089 and 5,565,332), a single-chain Fv (U.S. Pat. No. 4,946,778; Ward et al., Nature 334:544 (1989)), a bispecific antibody with two binding specificities (Segal et al., J Immunol Methods 248:1 (2001); Carter, J Immunol Methods 248:7 (2001)), a diabody, a triabody, and a tetrabody (Todorovska et al., J Immunol Methods 248:47 (2001)), as well as a Fab conjugate (dimer or trimer), and a minibody.

Many methods are known in the art for generating and/or identifying antibodies to a given target antigen. Harlow, Antibodies, Cold Spring Harbor Press, N.Y. (1989). In general, an isolated peptide (e.g., a variant protein of the present invention) is used as an immunogen and is administered to a mammalian organism, such as a rat, rabbit, hamster or mouse. Either a full-length protein, an antigenic peptide fragment (e.g., a peptide fragment containing a region that varies between a variant protein and a corresponding wild-type protein), or a fusion protein can be used. A protein used as an immunogen may be naturally-occurring, synthetic or recombinantly produced, and may be administered in combination with an adjuvant, including but not limited to, Freund's (complete and incomplete), mineral gels such as aluminum hydroxide, surface active substance such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, dinitrophenol, and the like.

Monoclonal antibodies can be produced by hybridoma technology, which immortalizes cells secreting a specific monoclonal antibody. Kohler and Milstein, Nature 256:495 (1975). The immortalized cell lines can be created in vitro by fusing two different cell types, typically lymphocytes, and tumor cells. The hybridoma cells may be cultivated in vitro or in vivo. Additionally, fully human antibodies can be generated by transgenic animals. He et al., J Immunol 169:595 (2002). Fd phage and Fd phagemid technologies may be used to generate and select recombinant antibodies in vitro. Hoogenboom and Chames, Immunol Today 21:371 (2000); Liu et al., J Mol Biol 315:1063 (2002). The complementarity-determining regions of an antibody can be identified, and synthetic peptides corresponding to such regions may be used to mediate antigen binding. U.S. Pat. No. 5,637,677.

Antibodies are preferably prepared against regions or discrete fragments of a variant protein containing a variant amino acid sequence as compared to the corresponding wild-type protein (e.g., a region of a variant protein that includes an amino acid encoded by a nonsynonymous cSNP, a region affected by truncation caused by a nonsense SNP that creates a stop codon, or a region resulting from the destruction of a stop codon due to read-through mutation caused by a SNP). Furthermore, preferred regions will include those involved in function/activity and/or protein/binding partner interaction. Such fragments can be selected on a physical property, such as fragments corresponding to regions that are located on the surface of the protein, e.g., hydrophilic regions, or can be selected based on sequence uniqueness, or based on the position of the variant amino acid residue(s) encoded by the SNPs provided by the present invention. An antigenic fragment will typically comprise at least about 8-10 contiguous amino acid residues in which at least one of the amino acid residues is an amino acid affected by a SNP disclosed herein. The antigenic peptide can comprise, however, at least 12, 14, 16, 20, 25, 50, 100 (or any other number in-between) or more amino acid residues, provided that at least one amino acid is affected by a SNP disclosed herein.

Detection of an antibody of the present invention can be facilitated by coupling (i.e., physically linking) the antibody or an antigen-reactive fragment thereof to a detectable substance. Detectable substances include, but are not limited to, various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, (3-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include ¹²⁵I, ¹³¹I, ³⁵S or ³H.

Antibodies, particularly the use of antibodies as therapeutic agents, are reviewed in: Morgan, “Antibody therapy for Alzheimer's disease,” Expert Rev Vaccines (1):53-9 (February 2003); Ross et al., “Anticancer antibodies,” Am J Clin Pathol 119(4):472-85 (April 2003); Goldenberg, “Advancing role of radiolabeled antibodies in the therapy of cancer,” Cancer Immunol Immunother 52(5):281-96 (May 2003); Epub Mar. 11, 2003; Ross et al., “Antibody-based therapeutics in oncology,” Expert Rev Anticancer Ther 3(1):107-21 (February 2003); Cao et al., “Bispecific antibody conjugates in therapeutics,” Adv Drug Deliv Rev 55(2):171-97 (February 2003); von Mehren et al., “Monoclonal antibody therapy for cancer,” Annu Rev Med 54:343-69 (2003); Epub Dec. 3, 2001; Hudson et al., “Engineered antibodies,” Nat Med 9(1):129-34 (January 2003); Brekke et al., “Therapeutic antibodies for human diseases at the dawn of the twenty-first century,” Nat Rev Drug Discov 2(1):52-62 (January 2003); Erratum in: Nat Rev Drug Discov 2(3):240 (March 2003); Houdebine, “Antibody manufacture in transgenic animals and comparisons with other systems,” Curr Opin Biotechnol 13(6):625-9 (December 2002); Andreakos et al., “Monoclonal antibodies in immune and inflammatory diseases,” Curr Opin Biotechnol 13(6):615-20 (December 2002); Kellermann et al., “Antibody discovery: the use of transgenic mice to generate human monoclonal antibodies for therapeutics,” Curr Opin Biotechnol 13(6):593-7 (December 2002); Pini et al., “Phage display and colony filter screening for high-throughput selection of antibody libraries,” Comb Chem High Throughput Screen 5(7):503-10 (November 2002); Batra et al., “Pharmacokinetics and biodistribution of genetically engineered antibodies,” Curr Opin Biotechnol 13(6):603-8 (December 2002); and Tangri et al., “Rationally engineered proteins or antibodies with absent or reduced immunogenicity,” Curr Med Chem 9(24):2191-9 (December 2002).

Uses of Antibodies

Antibodies can be used to isolate the variant proteins of the present invention from a natural cell source or from recombinant host cells by standard techniques, such as affinity chromatography or immunoprecipitation. In addition, antibodies are useful for detecting the presence of a variant protein of the present invention in cells or tissues to determine the pattern of expression of the variant protein among various tissues in an organism and over the course of normal development or disease progression. Further, antibodies can be used to detect variant protein in situ, in vitro, in a bodily fluid, or in a cell lysate or supernatant in order to evaluate the amount and pattern of expression. Also, antibodies can be used to assess abnormal tissue distribution, abnormal expression during development, or expression in an abnormal condition, such as in CVD, or during statin treatment. Additionally, antibody detection of circulating fragments of the full-length variant protein can be used to identify turnover.

Antibodies to the variant proteins of the present invention are also useful in pharmacogenomic analysis. Thus, antibodies against variant proteins encoded by alternative SNP alleles can be used to identify individuals that require modified treatment modalities.

Further, antibodies can be used to assess expression of the variant protein in disease states such as in active stages of the disease or in an individual with a predisposition to a disease related to the protein's function, such as CVD, or during the course of a treatment regime, such as during statin treatment. Antibodies specific for a variant protein encoded by a SNP-containing nucleic acid molecule of the present invention can be used to assay for the presence of the variant protein, such as to determine an individual's response to statin treatment (particularly for reducing their risk for CVD, particularly CHD, such as MI, or stroke) or to diagnose CVD or predisposition/susceptibility to CVD, as indicated by the presence of the variant protein.

Antibodies are also useful as diagnostic tools for evaluating the variant proteins in conjunction with analysis by electrophoretic mobility, isoelectric point, tryptic peptide digest, and other physical assays well known in the art.

Antibodies are also useful for tissue typing. Thus, where a specific variant protein has been correlated with expression in a specific tissue, antibodies that are specific for this protein can be used to identify a tissue type.

Antibodies can also be used to assess aberrant subcellular localization of a variant protein in cells in various tissues. The diagnostic uses can be applied, not only in genetic testing, but also in monitoring a treatment modality. Accordingly, where treatment is ultimately aimed at correcting the expression level or the presence of variant protein or aberrant tissue distribution or developmental expression of a variant protein, antibodies directed against the variant protein or relevant fragments can be used to monitor therapeutic efficacy.

The antibodies are also useful for inhibiting variant protein function, for example, by blocking the binding of a variant protein to a binding partner. These uses can also be applied in a therapeutic context in which treatment involves inhibiting a variant protein's function. An antibody can be used, for example, to block or competitively inhibit binding, thus modulating (agonizing or antagonizing) the activity of a variant protein. Antibodies can be prepared against specific variant protein fragments containing sites required for function or against an intact variant protein that is associated with a cell or cell membrane. For in vivo administration, an antibody may be linked with an additional therapeutic payload such as a radionuclide, an enzyme, an immunogenic epitope, or a cytotoxic agent. Suitable cytotoxic agents include, but are not limited to, bacterial toxin such as diphtheria, and plant toxin such as ricin. The in vivo half-life of an antibody or a fragment thereof may be lengthened by pegylation through conjugation to polyethylene glycol. Leong et al., Cytokine 16:106 (2001).

The invention also encompasses kits for using antibodies, such as kits for detecting the presence of a variant protein in a test sample. An exemplary kit can comprise antibodies such as a labeled or labelable antibody and a compound or agent for detecting variant proteins in a biological sample; means for determining the amount, or presence/absence of variant protein in the sample; means for comparing the amount of variant protein in the sample with a standard; and instructions for use.

Vectors and Host Cells

The present invention also provides vectors containing the SNP-containing nucleic acid molecules described herein. The term “vector” refers to a vehicle, preferably a nucleic acid molecule, which can transport a SNP-containing nucleic acid molecule. When the vector is a nucleic acid molecule, the SNP-containing nucleic acid molecule can be covalently linked to the vector nucleic acid. Such vectors include, but are not limited to, a plasmid, single or double stranded phage, a single or double stranded RNA or DNA viral vector, or artificial chromosome, such as a BAC, PAC, YAC, or MAC.

A vector can be maintained in a host cell as an extrachromosomal element where it replicates and produces additional copies of the SNP-containing nucleic acid molecules. Alternatively, the vector may integrate into the host cell genome and produce additional copies of the SNP-containing nucleic acid molecules when the host cell replicates.

The invention provides vectors for the maintenance (cloning vectors) or vectors for expression (expression vectors) of the SNP-containing nucleic acid molecules. The vectors can function in prokaryotic or eukaryotic cells or in both (shuttle vectors).

Expression vectors typically contain cis-acting regulatory regions that are operably linked in the vector to the SNP-containing nucleic acid molecules such that transcription of the SNP-containing nucleic acid molecules is allowed in a host cell. The SNP-containing nucleic acid molecules can also be introduced into the host cell with a separate nucleic acid molecule capable of affecting transcription. Thus, the second nucleic acid molecule may provide a trans-acting factor interacting with the cis-regulatory control region to allow transcription of the SNP-containing nucleic acid molecules from the vector. Alternatively, a trans-acting factor may be supplied by the host cell. Finally, a trans-acting factor can be produced from the vector itself. It is understood, however, that in some embodiments, transcription and/or translation of the nucleic acid molecules can occur in a cell-free system.

The regulatory sequences to which the SNP-containing nucleic acid molecules described herein can be operably linked include promoters for directing mRNA transcription. These include, but are not limited to, the left promoter from bacteriophage λ, the lac, TRP, and TAC promoters from E. coli, the early and late promoters from SV40, the CMV immediate early promoter, the adenovirus early and late promoters, and retrovirus long-terminal repeats.

In addition to control regions that promote transcription, expression vectors may also include regions that modulate transcription, such as repressor binding sites and enhancers. Examples include the SV40 enhancer, the cytomegalovirus immediate early enhancer, polyoma enhancer, adenovirus enhancers, and retrovirus LTR enhancers.

In addition to containing sites for transcription initiation and control, expression vectors can also contain sequences necessary for transcription termination and, in the transcribed region, a ribosome-binding site for translation. Other regulatory control elements for expression include initiation and termination codons as well as polyadenylation signals. A person of ordinary skill in the art would be aware of the numerous regulatory sequences that are useful in expression vectors. See, e.g., Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, N.Y. (2000).

A variety of expression vectors can be used to express a SNP-containing nucleic acid molecule. Such vectors include chromosomal, episomal, and virus-derived vectors, for example, vectors derived from bacterial plasmids, from bacteriophage, from yeast episomes, from yeast chromosomal elements, including yeast artificial chromosomes, from viruses such as baculoviruses, papovaviruses such as SV40, Vaccinia viruses, adenoviruses, poxviruses, pseudorabies viruses, and retroviruses. Vectors can also be derived from combinations of these sources such as those derived from plasmid and bacteriophage genetic elements, e.g., cosmids and phagemids. Appropriate cloning and expression vectors for prokaryotic and eukaryotic hosts are described in Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, N.Y. (2000).

The regulatory sequence in a vector may provide constitutive expression in one or more host cells (e.g., tissue specific expression) or may provide for inducible expression in one or more cell types such as by temperature, nutrient additive, or exogenous factor, e.g., a hormone or other ligand. A variety of vectors that provide constitutive or inducible expression of a nucleic acid sequence in prokaryotic and eukaryotic host cells are well known to those of ordinary skill in the art.

A SNP-containing nucleic acid molecule can be inserted into the vector by methodology well-known in the art. Generally, the SNP-containing nucleic acid molecule that will ultimately be expressed is joined to an expression vector by cleaving the SNP-containing nucleic acid molecule and the expression vector with one or more restriction enzymes and then ligating the fragments together. Procedures for restriction enzyme digestion and ligation are well known to those of ordinary skill in the art.

The vector containing the appropriate nucleic acid molecule can be introduced into an appropriate host cell for propagation or expression using well-known techniques. Bacterial host cells include, but are not limited to, Escherichia coli, Streptomyces spp., and Salmonella typhimurium. Eukaryotic host cells include, but are not limited to, yeast, insect cells such as Drosophila spp., animal cells such as COS and CHO cells, and plant cells.

As described herein, it may be desirable to express the variant peptide as a fusion protein. Accordingly, the invention provides fusion vectors that allow for the production of the variant peptides. Fusion vectors can, for example, increase the expression of a recombinant protein, increase the solubility of the recombinant protein, and aid in the purification of the protein by acting, for example, as a ligand for affinity purification. A proteolytic cleavage site may be introduced at the junction of the fusion moiety so that the desired variant peptide can ultimately be separated from the fusion moiety. Proteolytic enzymes suitable for such use include, but are not limited to, factor Xa, thrombin, and enterokinase. Typical fusion expression vectors include pGEX (Smith et al., Gene 67:31-40 (1988)), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) which fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amann et al., Gene 69:301-315 (1988)) and pET 11d (Studier et al., Gene Expression Technology: Methods in Enzymology 185:60-89 (1990)).

Recombinant protein expression can be maximized in a bacterial host by providing a genetic background wherein the host cell has an impaired capacity to proteolytically cleave the recombinant protein (S. Gottesman, Gene Expression Technology: Methods in Enzymology 185:119-128, Academic Press, Calif. (1990)). Alternatively, the sequence of the SNP-containing nucleic acid molecule of interest can be altered to provide preferential codon usage for a specific host cell, for example, E. coli. Wada et al., Nucleic Acids Res 20:2111-2118 (1992).

The SNP-containing nucleic acid molecules can also be expressed by expression vectors that are operative in yeast. Examples of vectors for expression in yeast (e.g., S. cerevisiae) include pYepSec1 (Baldari et al., EMBO J 6:229-234 (1987)), pMFa (Kurjan et al., Cell 30:933-943 (1982)), pJRY88 (Schultz et al., Gene 54:113-123 (1987)), and pYES2 (Invitrogen Corporation, San Diego, Calif.).

The SNP-containing nucleic acid molecules can also be expressed in insect cells using, for example, baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., Sf 9 cells) include the pAc series (Smith et al., Mol Cell Biol 3:2156-2165 (1983)) and the pVL series (Lucklow et al., Virology 170:31-39 (1989)).

In certain embodiments of the invention, the SNP-containing nucleic acid molecules described herein are expressed in mammalian cells using mammalian expression vectors. Examples of mammalian expression vectors include pCDM8 (B. Seed, Nature 329:840(1987)) and pMT2PC (Kaufman et al., EMBO J 6:187-195 (1987)).

The invention also encompasses vectors in which the SNP-containing nucleic acid molecules described herein are cloned into the vector in reverse orientation, but operably linked to a regulatory sequence that permits transcription of antisense RNA. Thus, an antisense transcript can be produced to the SNP-containing nucleic acid sequences described herein, including both coding and non-coding regions. Expression of this antisense RNA is subject to each of the parameters described above in relation to expression of the sense RNA (regulatory sequences, constitutive or inducible expression, tissue-specific expression).

The invention also relates to recombinant host cells containing the vectors described herein. Host cells therefore include, for example, prokaryotic cells, lower eukaryotic cells such as yeast, other eukaryotic cells such as insect cells, and higher eukaryotic cells such as mammalian cells.

The recombinant host cells can be prepared by introducing the vector constructs described herein into the cells by techniques readily available to persons of ordinary skill in the art. These include, but are not limited to, calcium phosphate transfection, DEAE-dextran-mediated transfection, cationic lipid-mediated transfection, electroporation, transduction, infection, lipofection, and other techniques such as those described in Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, N.Y. (2000).

Host cells can contain more than one vector. Thus, different SNP-containing nucleotide sequences can be introduced in different vectors into the same cell. Similarly, the SNP-containing nucleic acid molecules can be introduced either alone or with other nucleic acid molecules that are not related to the SNP-containing nucleic acid molecules, such as those providing trans-acting factors for expression vectors. When more than one vector is introduced into a cell, the vectors can be introduced independently, co-introduced, or joined to the nucleic acid molecule vector.

In the case of bacteriophage and viral vectors, these can be introduced into cells as packaged or encapsulated virus by standard procedures for infection and transduction. Viral vectors can be replication-competent or replication-defective. In the case in which viral replication is defective, replication can occur in host cells that provide functions that complement the defects.

Vectors generally include selectable markers that enable the selection of the subpopulation of cells that contain the recombinant vector constructs. The marker can be inserted in the same vector that contains the SNP-containing nucleic acid molecules described herein or may be in a separate vector. Markers include, for example, tetracycline or ampicillin-resistance genes for prokaryotic host cells, and dihydrofolate reductase or neomycin resistance genes for eukaryotic host cells. However, any marker that provides selection for a phenotypic trait can be effective.

While the mature variant proteins can be produced in bacteria, yeast, mammalian cells, and other cells under the control of the appropriate regulatory sequences, cell-free transcription and translation systems can also be used to produce these variant proteins using RNA derived from the DNA constructs described herein.

Where secretion of the variant protein is desired, which is difficult to achieve with multi-transmembrane domain containing proteins such as G-protein-coupled receptors (GPCRs), appropriate secretion signals can be incorporated into the vector. The signal sequence can be endogenous to the peptides or heterologous to these peptides.

Where the variant protein is not secreted into the medium, the protein can be isolated from the host cell by standard disruption procedures, including freeze/thaw, sonication, mechanical disruption, use of lysing agents, and the like. The variant protein can then be recovered and purified by well-known purification methods including, for example, ammonium sulfate precipitation, acid extraction, anion or cationic exchange chromatography, phosphocellulose chromatography, hydrophobic-interaction chromatography, affinity chromatography, hydroxylapatite chromatography, lectin chromatography, or high performance liquid chromatography.

It is also understood that, depending upon the host cell in which recombinant production of the variant proteins described herein occurs, they can have various glycosylation patterns, or may be non-glycosylated, as when produced in bacteria. In addition, the variant proteins may include an initial modified methionine in some cases as a result of a host-mediated process.

For further information regarding vectors and host cells, see Current Protocols in Molecular Biology, John Wiley & Sons, N.Y.

Uses of Vectors and Host Cells, and Transgenic Animals

Recombinant host cells that express the variant proteins described herein have a variety of uses. For example, the cells are useful for producing a variant protein that can be further purified into a preparation of desired amounts of the variant protein or fragments thereof. Thus, host cells containing expression vectors are useful for variant protein production.

Host cells are also useful for conducting cell-based assays involving the variant protein or variant protein fragments, such as those described above as well as other formats known in the art. Thus, a recombinant host cell expressing a variant protein is useful for assaying compounds that stimulate or inhibit variant protein function. Such an ability of a compound to modulate variant protein function may not be apparent from assays of the compound on the native/wild-type protein, or from cell-free assays of the compound. Recombinant host cells are also useful for assaying functional alterations in the variant proteins as compared with a known function.

Genetically-engineered host cells can be further used to produce non-human transgenic animals. A transgenic animal is preferably a non-human mammal, for example, a rodent, such as a rat or mouse, in which one or more of the cells of the animal include a transgene. A transgene is exogenous DNA containing a SNP of the present invention which is integrated into the genome of a cell from which a transgenic animal develops and which remains in the genome of the mature animal in one or more of its cell types or tissues. Such animals are useful for studying the function of a variant protein in vivo, and identifying and evaluating modulators of variant protein activity. Other examples of transgenic animals include, but are not limited to, non-human primates, sheep, dogs, cows, goats, chickens, and amphibians. Transgenic non-human mammals such as cows and goats can be used to produce variant proteins which can be secreted in the animal's milk and then recovered.

A transgenic animal can be produced by introducing a SNP-containing nucleic acid molecule into the male pronuclei of a fertilized oocyte, e.g., by microinjection or retroviral infection, and allowing the oocyte to develop in a pseudopregnant female foster animal. Any nucleic acid molecules that contain one or more SNPs of the present invention can potentially be introduced as a transgene into the genome of a non-human animal.

Any of the regulatory or other sequences useful in expression vectors can form part of the transgenic sequence. This includes intronic sequences and polyadenylation signals, if not already included. A tissue-specific regulatory sequence(s) can be operably linked to the transgene to direct expression of the variant protein in particular cells or tissues.

Methods for generating transgenic animals via embryo manipulation and microinjection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866 and 4,870,009, both by Leder et al.; U.S. Pat. No. 4,873,191 by Wagner et al., and in B. Hogan, Manipulating the Mouse Embryo, Cold Spring Harbor Laboratory Press, N.Y. (1986). Similar methods are used for production of other transgenic animals. A transgenic founder animal can be identified based upon the presence of the transgene in its genome and/or expression of transgenic mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene can further be bred to other transgenic animals carrying other transgenes. A transgenic animal also includes a non-human animal in which the entire animal or tissues in the animal have been produced using the homologously recombinant host cells described herein.

In another embodiment, transgenic non-human animals can be produced which contain selected systems that allow for regulated expression of the transgene. One example of such a system is the cre/loxP recombinase system of bacteriophage P1. Lakso et al., PNAS 89:6232-6236 (1992). Another example of a recombinase system is the FLP recombinase system of S. cerevisiae. O'Gorman et al., Science 251:1351-1355 (1991). If a cre/loxP recombinase system is used to regulate expression of the transgene, animals containing transgenes encoding both the Cre recombinase and a selected protein are generally needed. Such animals can be provided through the construction of “double” transgenic animals, e.g., by mating two transgenic animals, one containing a transgene encoding a selected variant protein and the other containing a transgene encoding a recombinase.

Clones of the non-human transgenic animals described herein can also be produced according to the methods described, for example, in I. Wilmut et al., Nature 385:810-813 (1997) and PCT International Publication Nos. WO 97/07668 and WO 97/07669. In brief, a cell (e.g., a somatic cell) from the transgenic animal can be isolated and induced to exit the growth cycle and enter G_(o) phase. The quiescent cell can then be fused, e.g., through the use of electrical pulses, to an enucleated oocyte from an animal of the same species from which the quiescent cell is isolated. The reconstructed oocyte is then cultured such that it develops to morula or blastocyst and then transferred to pseudopregnant female foster animal. The offspring born of this female foster animal will be a clone of the animal from which the cell (e.g., a somatic cell) is isolated.

Transgenic animals containing recombinant cells that express the variant proteins described herein are useful for conducting the assays described herein in an in vivo context. Accordingly, the various physiological factors that are present in vivo and that could influence ligand or substrate binding, variant protein activation, signal transduction, or other processes or interactions, may not be evident from in vitro cell-free or cell-based assays. Thus, non-human transgenic animals of the present invention may be used to assay in vivo variant protein function as well as the activities of a therapeutic agent or compound that modulates variant protein function/activity or expression. Such animals are also suitable for assessing the effects of null mutations (i.e., mutations that substantially or completely eliminate one or more variant protein functions).

For further information regarding transgenic animals, see Houdebine, “Antibody manufacture in transgenic animals and comparisons with other systems,” Curr Opin Biotechnol 13(6):625-9 (December 2002); Petters et al., “Transgenic animals as models for human disease,” Transgenic Res 9(4-5):347-51, discussion 345-6 (2000); Wolf et al., “Use of transgenic animals in understanding molecular mechanisms of toxicity,” J Pharm Pharmacol 50(6):567-74 (June 1998); Echelard, “Recombinant protein production in transgenic animals,” Curr Opin Biotechnol 7(5):536-40 (October 1996); Houdebine, “Transgenic animal bioreactors,” Transgenic Res 9(4-5):305-20 (2000); Pirity et al., “Embryonic stem cells, creating transgenic animals,” Methods Cell Biol 57:279-93 (1998); and Robl et al., “Artificial chromosome vectors and expression of complex proteins in transgenic animals,” Theriogenology 59(1):107-13 (January 2003).

EXAMPLES

The following examples are offered to illustrate, but not limit, the claimed invention.

Example 1: SNPs Associated with Statin Response in CARE, WOSCOPS, and PROVE IT-TIMI 22

Overview

In the study described here in Example 1, cohort and case-only study designs were used to identify SNPs associated with response to statin treatment. The entire cohort (individuals with and without incident CHD or CVD events) or cases only (only individuals with an incident CHD or CVD event) were analyzed in sample sets from the CARE, WOSCOPS, and PROVE IT. Specifically, analyses were carried out using these three sample sets to identify SNPs associated with a reduction in the risk of CHD or CVD (CVD includes CHD and stroke), the results of which are provided in Tables 4-7 and Tables 9-18 (Tables 9-18 provide additional genotyped SNPs as well as imputed SNPs).

Tables 4-7 provide results of analyses of statin response for either CHD or CVD reduction, in three genetic models (dominant, recessive, and additive). Tables 4-7 provide SNPs that had a synergy index (odds ratio) with P value lower than 10⁻⁴ in a meta-analysis of CARE and WOSCOPS combined (Table 4-5) or in a meta-analysis of CARE, WOSCOPS, and PROVE-IT combined (Table 6-7), in any genetic model in either the CHD or CVD endpoint. Tables 4-5 provide meta-analyses of CARE and WOSCOPS combined, as well as logistic regression analysis of each sample set individually. Tables 6-7 provide meta-analyses of CARE, WOSCOPS, and PROVE-IT combined, as well as logistic regression analysis of each sample set individually.

Tables 5 and 7 provide analyses of certain LD SNPs in CARE and WOSCOPS (Table 5) and in CARE, WOSCOPS, and PROVE-IT (Table 7). For some SNPs, case-only data was available for a first SNP while cohort data was available for a SNP in LD with the first SNP (LD SNP), which occurred when a working kPCR assay could not be made for the first SNP. For these SNPs, the data for case-only analysis and the available data for the cohort is reported. The meta-analysis was performed with the cohort data when available. These SNPs are listed in Tables 5 and 7, with the two SNPs in LD listed one below the other, and the degree of LD (r²) between each of these pairs of SNPs is provided in Table 8.

CARE, WOSCOPS, and PROVE IT-TIMI 22 Sample Sets

The CARE (“Cholesterol and Recurrent Events”) and WOSCOPS (“West of Scotland Coronary Prevention Study”) studies were prospective trials that assessed the effect of pravastatin (40 mg/day) on the prevention of MI and CHD. CARE was a secondary prevention trial and WOSCOPS was a primary prevention trial. The PROVE IT-TIMI 22 (“Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction 22”; which is interchangeably referred to herein as “PROVE-IT”) trial evaluated the effectiveness of intensive therapy with high-dose atorvastatin (80 mg/day) versus moderate therapy with standard-dose pravastatin (40 mg/day, which was the dose used in the CARE and WOSCOPS trials) in preventing death or cardiovascular events in patients with a recent acute coronary syndrome.

These trials and the sample sets from these trials (such as the inclusion criteria for participants) are described in the following references. Those portions of each of the following references that pertain to the CARE, WOSCOPS, and PROVE-IT trials and sample sets are hereby incorporated by reference. CARE is described in Sacks et al., “Cholesterol and Recurrent Events Trial Investigators. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels”, N Engl J Med 1996; 335:1001-9, and WOSCOPS is described in Shepherd et al., “West of Scotland Coronary Prevention Study Group. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia”, N Engl J Med 1995; 333:1301-7. PROVE-IT is described in lakoubova et al., Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study”, J Am Coll Cardiol. 2008 Jan. 29; 51(4):449-55 and Cannon et al., “Intensive versus moderate lipid lowering with statins after acute coronary syndromes”, N Engl J Med 2004; 350:1495-504.

Endpoints

The endpoint definitions used in these analyses of CARE, WOSCOPS, and PROVE-IT (the results of which are provided in Tables 4-7) were as follows. The CHD endpoint was defined in the analyses herein of CARE as a composite endpoint of fatal CHD, definite non-fatal MI, or revascularization, and was defined in the analyses herein of WOSCOPS as a composite endpoint of death from CHD, nonfatal MI, or revascularization. In both the CARE and WOSCOPS analyses herein, the CVD endpoint was defined as a composite endpoint of CHD or stroke. The analyses herein of PROVE-IT analyzed the primary endpoint of PROVE-IT, which was a composite endpoint of revascularization (if performed at least 30 days after randomization), unstable angina requiring hospitalization, MI, all causes of death, or stroke. Thus, there was only one endpoint for PROVE-IT (the composite primary endpoint of the original PROVE-IT study, which includes some stroke cases), and this endpoint was used in the meta-analysis for both CHD and CVD provided in Tables 6-7. With respect to stroke, in the analyses herein of CARE and PROVE-IT, stroke was defined as stroke or transient ischemic attack (TIA), and in the analyses herein of WOSCOPS, stroke was defined as fatal or non-fatal stroke. Revascularization, which can include percutaneous transluminal coronary angioplasty (PTCA), stent placement, and coronary artery bypass graft (CABG), are medical interventions that indicate the presence of CHD.

Study Designs

Cohort and case-only study designs were used to identify SNPs associated with response to statin treatment. The entire cohort (individuals with and without incident CHD or CVD events; identified as “cohort” in the “Source” column of Tables 4-7) or only individuals with an incident CHD or CVD event (identified as “CaseOnly” in the “Source” column of Tables 4-7) were analyzed in sample sets from the CARE, WOSCOPS, and PROVE-IT trials to test whether the reduction of CHD/CVD events by statin therapy (for CARE and WOSCOPS studies), or by high dose atorvastatin therapy (for the PROVE IT study), differed according to genotype (a treatment by SNP interaction) for each SNP evaluated in the study.

For each SNP, a logistic regression model having treatment status as the dependent variable and SNP as the independent predictor variable was performed, with terms for age, sex and race included in the model as covariates. The anti-log of the regression coefficient corresponding to the SNP is an estimate of the synergy index (SI) (Davis et al., “Imputing gene-treatment interactions when the genotype distribution is unknown using case-only and putative placebo analyses-a new method for the Genetics of Hypertension Associated Treatment (GenHAT) study”, Statistics in Medicine 23: (2004), pages 2413-2427). The SI is a ratio of odds ratios: for example in the CARE and WOSCOPS studies, the SI represents the factor by which the odds-ratio of statin treatment, compared with placebo, among major homozygous individuals is multiplied by in order to obtain the odds-ratio of treatment vs. placebo among heterozygous individuals; and multiplied by a second time to obtain the odds-ratio of treatment vs. placebo in minor homozygous individuals. The case-only study design results in a valid estimate of the SI under the assumption that genotype and treatment are independent in the population. In a randomized clinical trial, genotype and treatment are independent by design. The p-value for the regression coefficient corresponding to the SNP results from a test of the null hypothesis that the regression coefficient is equal to zero (SI is equal to one) and thus small p-values indicate the SI is unlikely equal to one and that the effect of treatment likely differs by genotype.

The logistic regression models were performed separately for each of CARE, WOSCOPS, and PROVE-IT in order to obtain study-specific results. A meta-analysis was then used to estimate the combined evidence for interaction when considering either the CARE and WOSCOPS studies (Tables 4-5), or all three studies (CARE, WOSCOPS, and PROVE-IT) (Tables 6-7). The meta-analysis used the inverse variance method (Rothman et al., 1998; Modern Epidemiology, 2nd edition, Lippincott Williams & Wilkins, Philadelphia, Pa., pages 660-661) to calculate the combined SI using a weighted average of the effects of the individual studies with weights equal to the inverse variance from each study.

The logistic regression and meta-analyses were performed using PLINK version 1.07 (Purcell et al. (2007), “PLINK: A tool set for whole-genome association and population-based linkage analyses”, Am. J. Hum. Genet. 81, 559-575).

Regarding case-only study designs specifically, further information about these study designs is provided in Piegorsch et al., “Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies”, Statistics in Medicine 13 (1994) (pages 153-162); Khoury et al., “Nontraditional Epidemiologic Approaches in the Analysis of Gene-Environment Interaction: Case-Control Studies with No Controls!”, American Journal of Epidemiology 144:3 (1996) (pages 207-213); Pierce et al., “Case-only genome-wide interaction study of disease risk, prognosis and treatment”, Genet Epidemiol. 2010 January; 34(1):7-15; Begg et al., “Statistical analysis of molecular epidemiology studies employing case-series”, Cancer Epidemiology Biomarkers and Prevention 3 (1994) pp 173-175; Yang et al., “Sample Size Requirements in Case-Only Designs to Detect Gene-Environment Interaction”, American Journal of Epidemiology 146:9 (1997) pp 713-720; Albert et al., “Limitations of the Case-only Design for Identifying Gene-Environment Interactions”, American Journal of Epidemiology 154:8 (2001) pp 687-693; and Wang et al., “Population Stratification Bias in the Case-Only Study for Gene-Environment Interactions”, American Journal of Epidemiology 168:2 (2008) pp 197-201, each of which is incorporated herein by reference in its entirety. Further information about genome-wide association studies is provided in Wellcome Trust Case Control Consortium, “Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls”, Nature. 2007 Jun. 7; 447(7145):661-78 and Ikram et al., “Genomewide association studies of stroke”, N Engl J Med. 2009 Apr. 23; 360(17):1718-28.

Identification of Additional Statin Response-Associated SNPs by Imputation and Genotyping

Additional genotyped and imputed SNPs were identified as being associated with statin response in the CARE, WOSCOPS, and PROVE-IT sample sets, and these additional SNPs are provided in Tables 9-18. The association of certain of these SNPs with statin response was identified by genotyping, whereas the association of certain other SNPs with statin response was identified by imputation. Imputation involves imputing the allele/genotype present at a SNP for each individual in the sample set (CARE, WOSCOPS, and PROVE-IT) rather than directly genotyping the SNP in a sample from the individual. Thus, Tables 9-18 include SNPs identified by imputation as well as SNPs identified by genotyping, and the column labeled “Source” in Tables 9-18 indicates whether each SNP was genotyped or imputed (all of the SNPs provided in Tables 4-7 were identified by genotyping).

Specifically, Tables 9-18 provide SNPs for which the p-value for a random effect was lower than 10⁻⁴ for either the meta-analysis of CARE and WOSCOPS combined or the meta-analysis of CARE, WOSCOPS, and PROVE-IT combined, for either the CHD or CVD endpoint, and for any genetic model (dominant, recessive, additive, or genotypic). Association interaction between statin response and either the CHD or CVD phenotype was performed. SNPs were either imputed or genotyped.

Imputation was carried out using the BEAGLE genetic analysis program to analyze genotyping data from the HapMap project (The International HapMap Consortium, NCBI, NLM, NIH). Imputation and the BEAGLE program (including the modeling algorithm that BEAGLE utilizes) are described in the following references: Browning, “Missing data imputation and haplotype phase inference for genome-wide association studies”, Hum Genet (2008) 124:439-450 (which reviews imputation and BEAGLE); B L Browning and S R Browning (2009) “A unified approach to genotype imputation and haplotype phase inference for large data sets of trios and unrelated individuals”. Am J Hum Genet 84:210-223 (which describes BEAGLE's methods for imputing ungenotyped markers and phasing parent-offspring trios); S R Browning and B L Browning (2007) “Rapid and accurate haplotype phasing and missing data inference for whole genome association studies using localized haplotype clustering”. Am J Hum Genet 81:1084-1097 (which describes BEAGLE's methods for inferring haplotype phase or sporadic missing data in unrelated individuals); B L Browning and S R Browning (2007) “Efficient multilocus association mapping for whole genome association studies using localized haplotype clustering”. Genet Epidemiol 31:365-375 (which describes BEAGLE's methods for association testing); S R Browning (2006) “Multilocus association mapping using variable-length Markov chains”. Am J Hum Genet 78:903-13 (which describes BEAGLE's haplotype frequency model); and B L Browning and S R Browning (2008) “Haplotypic analysis of Wellcome Trust Case Control Consortium data”. Human Genetics 123:273-280 (which describes an example in which BEAGLE was used to analyze a large genome-wide association study). Each of these references related to imputation and the BEAGLE program is incorporated herein by reference in its entirety.

Example 2: Polymorphism rs11556924 in the ZC3HC1 Gene is Associated with Differential CHD Risk Reduction by Statin Therapy in CARE and WOSCOPS

A case-only study design was used to test whether the reduction of CHD events by statin therapy (for CARE and WOSCOPS studies) differed according to genotype (a treatment by SNP interaction) for each SNP evaluated in the study.

Herein in Example 2, SNPs previously reported to be associated with coronary artery disease (Schunkert et al., “Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease”, Nat Genet. 2011 Mar. 6; and Peden et al., “A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease”, Nat Genet. 2011 Mar. 6) were analyzed using the same methodology as described above in Example 1 in order to determine whether any of these SNP are associated with differential CHD risk reduction by statin therapy in a genome wide association study conducted among cases of CARE and WOSCOPS.

It was determined from this analysis that SNP rs11556924 (hCV31283062) in the ZC3HC1 gene is associated with differential reduction of CHD risk by pravastatin therapy in both CARE and WOSCOPS (see Table 19).

Example 3: SNPs Around Chromosomal Locations 9p21 and 12p13 (NINJ2 and B4GALNT3 Gene Region) Associated with Stroke Statin Response and/or Stroke Risk

Example 3 relates to genetic polymorphisms that are associated with stroke risk and/or stroke statin response (reduction of stroke risk by statin treatment) (Tables 20-21) and CHD statin response (Table 22).

Table 20 provides SNPs associated with stroke risk and/or stroke statin response in the CARE sample set. For example, SNPs rs10757278 and rs1333049 at chromosomal location 9p21 were associated with a reduction of stroke events by statin treatment in CARE, particularly for heterozygotes (see Table 20). Furthermore, SNPs rs12425791 and rs11833579 at chromosomal location 12p13 near the NINJ2 gene were associated with stroke risk in the placebo arm of CARE (see Table 20). SNPs rs12425791 and rs11833579 were also associated with stroke statin response in that the homozygous and heterozygous carriers of either of these SNPs (i.e., carriers of the ‘A’ allele for either rs12425791 or rs11833579) had a greater reduction in stroke events with statin treatment compared with noncarriers (see Table 20). Consistent with the CARE trial, the stroke endpoint in the analysis for which the results are provided in Tables 20-21 included stroke as well as transient ischemic attack (TIA).

Fine-mapping at the chromosome 12p13 locus was carried out by selecting 77 tagging SNPs from a 400 kb region of the chromosome 12p13 locus which covered the NINJ2 gene and other genes, genotyping these 77 SNPs, and further imputing the genotypes of approximately 250 additional SNPs in this region, for individuals in the CARE study. Analyzing these fine-mapping SNPs for association with stroke risk in the placebo arm of CARE and for stroke statin response in CARE identified SNP rs873134 in the B4GALNT3 gene in the chromosome 12p13 region near NINJ2 (see Table 21).

Table 22 provides results of an analysis of CHD statin response in CARE. Table 22 shows that SNP rs873134 is associated with response to statin treatment for reducing the risk of CHD (as well as for reducing the risk of stroke, as shown in Table 21). Specifically, Table 22 shows that SNP rs873134 is associated with a reduced occurrence of recurrent MI in individuals in the CARE study who were treated with statins. Thus, SNP rs873134 is an example of a SNP that is associated with statin response for reducing risk for both stroke and CHD. In the analysis for which the results are provided in Table 22, the endpoint was recurrent MI, and the analysis was adjusted for age, gender, hypertension, diabetes, base LDL and HDL, and whether an individual was a current smoker.

Example 4: LD SNPs Associated with Statin Response and CVD

Another investigation was conducted to identify additional SNPs that are in high linkage disequilibrium (LD) with certain “interrogated SNPs” that have been found to be associated with response to statin treatment (particularly for reducing the risk of CVD, especially CHD such as MI). The “interrogated SNPs” were those SNPs provided in Tables 4-22 (the interrogated SNPs are shown in columns 1-2 of Table 3, which indicates the hCV and rs identification numbers of each interrogated SNP), and the LD SNPs which were identified as being in high LD are provided in Table 3 (in the columns labeled “LD SNP”, which indicate the hCV and rs identification numbers of each LD SNP).

Specifically, Table 3 provides LD SNPs from the HapMap database (NCBI, NLM, NIH) that have linkage disequilibrium r² values of at least 0.9 (the threshold r² value, which may also be designated as r_(T) ²) with an interrogated SNP. Each of these LD SNPs from the HapMap database is within 500 kb of its respective interrogated SNP, and the r² values are calculated based on genotypes of HapMap Caucasian subjects. If an interrogated SNP is not in the HapMap database, then there will not be any LD SNPs listed in Table 3 for that interrogated SNP.

As an example in Table 3, the interrogated SNP rs688358 (hCV1056543) was calculated to be in LD with rs675163 (hCV1056544) at an r² value of 1 (which is above the threshold r² value of 0.9), thus establishing the latter SNP as a marker associated with statin response as well.

In this example, the threshold r² value was set at 0.9. However, the threshold r² value can be set at other values such that one of ordinary skill in the art would consider that any two SNPs having an r² value greater than or equal to the threshold r² value would be in sufficient LD with each other such that either SNP is useful for the same utilities, such as determining an individual's response to statin treatment. For example, in various embodiments, the threshold r² value used to classify SNPs as being in sufficient LD with an interrogated SNP (such that these LD SNPs can be used for the same utilities as the interrogated SNP, for example) can be set at, for example, 0.7, 0.75, 0.8, 0.85, 0.95, 0.96, 0.97, 0.98, 0.99, 1, etc. (or any other threshold r² value in-between these values). Threshold r² values may be utilized with or without considering power or other calculations.

Sequences, SNP information, and associated gene/transcript/protein information for each of the LD SNPs listed in Table 3 is provided in Tables 1-2. Thus, for any LD SNP listed in Table 3, sequence and allele information (or other information) can be found by searching Tables 1-2 using the hCV or rs identification number of the LD SNP of interest.

All publications and patents cited in this specification are herein incorporated by reference in their entirety. Modifications and variations of the described compositions, methods and systems of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments and certain working examples, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above-described modes for carrying out the invention that are obvious to those skilled in the field of molecular biology, genetics and related fields are intended to be within the scope of the following claims.

TABLE 3 Interrogated SNP Interrogated (hCV #) SNP (rs #) LD SNP (hCV #) LD SNP (rs #) Threshold r² r² hCV1056543 rs688358 hCV1056544 rs675163 0.9 1 hCV1056543 rs688358 hCV32014853 rs11221097 0.9 1 hCV1056543 rs688358 hCV767324 rs687047 0.9 1 hCV1056544 rs675163 hCV1056543 rs688358 0.9 1 hCV1056544 rs675163 hCV32014843 rs11221075 0.9 1 hCV1056544 rs675163 hCV32014853 rs11221097 0.9 1 hCV1056544 rs675163 hCV767324 rs687047 0.9 1 hCV11435810 rs7808536 hCV11435811 rs2057903 0.9 1 hCV11435810 rs7808536 hCV16010888 rs2402516 0.9 0.9445 hCV11435810 rs7808536 hCV16151622 rs2896295 0.9 1 hCV11435810 rs7808536 hCV2580015 rs6973461 0.9 1 hCV11435810 rs7808536 hCV26499740 rs1344081 0.9 0.9396 hCV11435810 rs7808536 hCV29630277 rs7799541 0.9 1 hCV11435810 rs7808536 hCV29720798 rs10228725 0.9 1 hCV11435810 rs7808536 hCV29738883 rs10237648 0.9 1 hCV11435810 rs7808536 hCV29865261 rs10226287 0.9 1 hCV11435810 rs7808536 hCV30243451 rs10270624 0.9 1 hCV11435810 rs7808536 hCV30441808 rs10487413 0.9 0.9485 hCV11435810 rs7808536 hCV31281599 rs13438543 0.9 1 hCV11544885 rs1536506 hCV16243612 rs2478888 0.9 0.963 hCV11544885 rs1536506 hCV16243614 rs2478885 0.9 0.9587 hCV11544885 rs1536506 hCV16252195 rs2504709 0.9 1 hCV11544885 rs1536506 hCV16252196 rs2504710 0.9 1 hCV11544885 rs1536506 hCV2005097 rs2478886 0.9 0.9622 hCV11544885 rs1536506 hCV2005121 rs2504708 0.9 1 hCV11544885 rs1536506 hCV2005126 rs1536507 0.9 1 hCV11544885 rs1536506 hCV2005128 rs2504705 0.9 1 hCV11544885 rs1536506 hCV2005129 rs2478872 0.9 1 hCV11544885 rs1536506 hCV2005135 rs2504702 0.9 0.9615 hCV11544885 rs1536506 hCV2005136 rs1998950 0.9 0.9273 hCV11544885 rs1536506 hCV27016744 rs2478874 0.9 0.9625 hCV11544885 rs1536506 hCV8768604 rs1327283 0.9 0.9447 hCV11544885 rs1536506 hCV8768614 rs1342619 0.9 0.9637 hCV11544885 rs1536506 hCV992360 rs748514 0.9 0.9269 hCV1166098 rs4660234 hCV1166103 rs12407412 0.9 1 hCV1166098 rs4660234 hCV1166105 rs11576627 0.9 1 hCV1166098 rs4660234 hCV30202184 rs6685920 0.9 1 hCV1166103 rs12407412 hCV1166098 rs4660234 0.9 1 hCV1166103 rs12407412 hCV1166105 rs11576627 0.9 1 hCV1166103 rs12407412 hCV30202184 rs6685920 0.9 1 hCV1166105 rs11576627 hCV1166098 rs4660234 0.9 1 hCV1166105 rs11576627 hCV1166103 rs12407412 0.9 1 hCV1166105 rs11576627 hCV30202184 rs6685920 0.9 1 hCV11675665 rs2574 hCV11226242 rs2280210 0.9 1 hCV11675665 rs2574 hCV11675666 rs2575 0.9 0.9636 hCV11675665 rs2574 hCV245252 rs9835936 0.9 0.9636 hCV11675665 rs2574 hCV474806 rs11927308 0.9 1 hCV11686367 rs7955901 hCV11686374 rs7957932 0.9 0.9161 hCV11686367 rs7955901 hCV171102 rs7313973 0.9 0.9568 hCV11686367 rs7955901 hCV240133 rs4760895 0.9 0.9644 hCV11686367 rs7955901 hCV240134 rs7138300 0.9 0.9432 hCV11686367 rs7955901 hCV2745807 rs2063591 0.9 0.9303 hCV11686367 rs7955901 hCV2745815 rs1512991 0.9 1 hCV11686367 rs7955901 hCV2745822 rs1913201 0.9 0.9432 hCV11686367 rs7955901 hCV2745828 rs10879240 0.9 0.9274 hCV11686367 rs7955901 hCV27952502 rs4760894 0.9 0.9644 hCV11686367 rs7955901 hCV27952503 rs4760785 0.9 0.9644 hCV11686367 rs7955901 hCV29120310 rs7298255 0.9 0.9442 hCV11686367 rs7955901 hCV31190748 rs7959965 0.9 0.9442 hCV11686367 rs7955901 hCV31190777 rs10784891 0.9 1 hCV11686367 rs7955901 hDV72015086 rs7956274 0.9 1 hCV11819777 rs13172910 hCV26478734 rs11956952 0.9 1 hCV11819777 rs13172910 hCV31237558 rs6898857 0.9 1 hCV11819780 rs12153185 hCV11819782 rs12719415 0.9 1 hCV11819780 rs12153185 hCV2575318 rs7711358 0.9 0.9232 hCV11819780 rs12153185 hCV2575336 rs2418541 0.9 0.9232 hCV11819780 rs12153185 hCV2575340 rs11242020 0.9 0.9232 hCV11819780 rs12153185 hCV26478744 rs2016194 0.9 1 hCV11819780 rs12153185 hCV26478745 rs2108426 0.9 1 hCV11819780 rs12153185 hCV26478747 rs2190598 0.9 1 hCV11819780 rs12153185 hCV26478763 rs2418542 0.9 0.9232 hCV11819780 rs12153185 hCV27996154 rs4836502 0.9 1 hCV11819780 rs12153185 hCV2961244 rs2418548 0.9 1 hCV11819780 rs12153185 hCV2961250 rs4836507 0.9 1 hCV11819780 rs12153185 hCV2961252 rs10067895 0.9 1 hCV11819780 rs12153185 hCV2961253 rs2190600 0.9 1 hCV11819780 rs12153185 hCV2961259 rs11242023 0.9 0.9571 hCV11819780 rs12153185 hCV2961260 rs11242022 0.9 0.9785 hCV11819780 rs12153185 hCV2961261 rs11242021 0.9 1 hCV11819780 rs12153185 hCV2961267 rs1476714 0.9 1 hCV11819780 rs12153185 hCV2961268 rs2108425 0.9 1 hCV11819780 rs12153185 hCV2961269 rs2158958 0.9 1 hCV11819780 rs12153185 hCV2961270 rs9327555 0.9 1 hCV11819780 rs12153185 hCV2961278 rs7446891 0.9 1 hCV11819780 rs12153185 hCV2961280 rs10520072 0.9 1 hCV11819780 rs12153185 hCV2961282 rs917295 0.9 1 hCV11819780 rs12153185 hCV2961284 rs10054055 0.9 0.9573 hCV11819780 rs12153185 hCV2961296 rs10051148 0.9 0.9608 hCV11819780 rs12153185 hCV2961297 rs2158961 0.9 0.9616 hCV11819780 rs12153185 hCV2961306 rs264129 0.9 0.9358 hCV11819780 rs12153185 hCV30621656 rs10478919 0.9 0.9232 hCV11819780 rs12153185 hCV31237567 rs11749272 0.9 0.9232 hCV11819780 rs12153185 hCV346713 rs1990023 0.9 0.9358 hCV11819780 rs12153185 hCV546489 rs264122 0.9 0.9573 hCV11819780 rs12153185 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hCV2961250 rs4836507 hCV27996154 rs4836502 0.9 1 hCV2961250 rs4836507 hCV2961244 rs2418548 0.9 1 hCV2961250 rs4836507 hCV2961252 rs10067895 0.9 1 hCV2961250 rs4836507 hCV2961253 rs2190600 0.9 1 hCV2961250 rs4836507 hCV2961259 rs11242023 0.9 0.9621 hCV2961250 rs4836507 hCV2961260 rs11242022 0.9 1 hCV2961250 rs4836507 hCV2961261 rs11242021 0.9 1 hCV2961250 rs4836507 hCV2961267 rs1476714 0.9 1 hCV2961250 rs4836507 hCV2961268 rs2108425 0.9 1 hCV2961250 rs4836507 hCV2961269 rs2158958 0.9 1 hCV2961250 rs4836507 hCV2961270 rs9327555 0.9 1 hCV2961250 rs4836507 hCV2961278 rs7446891 0.9 1 hCV2961250 rs4836507 hCV2961280 rs10520072 0.9 1 hCV2961250 rs4836507 hCV2961282 rs917295 0.9 1 hCV2961250 rs4836507 hCV2961284 rs10054055 0.9 0.9616 hCV2961250 rs4836507 hCV2961296 rs10051148 0.9 0.9623 hCV2961250 rs4836507 hCV2961297 rs2158961 0.9 0.9634 hCV2961250 rs4836507 hCV2961306 rs264129 0.9 0.9232 hCV2961250 rs4836507 hCV30621656 rs10478919 0.9 0.927 hCV2961250 rs4836507 hCV31237567 rs11749272 0.9 0.927 hCV2961250 rs4836507 hCV346713 rs1990023 0.9 0.9232 hCV2961250 rs4836507 hCV546489 rs264122 0.9 0.9616 hCV2961250 rs4836507 hCV8932829 rs1116596 0.9 0.927 hCV2961252 rs10067895 hCV11819780 rs12153185 0.9 1 hCV2961252 rs10067895 hCV11819782 rs12719415 0.9 1 hCV2961252 rs10067895 hCV2575318 rs7711358 0.9 0.927 hCV2961252 rs10067895 hCV2575336 rs2418541 0.9 0.927 hCV2961252 rs10067895 hCV2575340 rs11242020 0.9 0.927 hCV2961252 rs10067895 hCV26478744 rs2016194 0.9 0.9198 hCV2961252 rs10067895 hCV26478745 rs2108426 0.9 0.9135 hCV2961252 rs10067895 hCV26478747 rs2190598 0.9 1 hCV2961252 rs10067895 hCV26478763 rs2418542 0.9 0.927 hCV2961252 rs10067895 hCV27996154 rs4836502 0.9 1 hCV2961252 rs10067895 hCV2961244 rs2418548 0.9 1 hCV2961252 rs10067895 hCV2961250 rs4836507 0.9 1 hCV2961252 rs10067895 hCV2961253 rs2190600 0.9 1 hCV2961252 rs10067895 hCV2961259 rs11242023 0.9 0.9621 hCV2961252 rs10067895 hCV2961260 rs11242022 0.9 1 hCV2961252 rs10067895 hCV2961261 rs11242021 0.9 1 hCV2961252 rs10067895 hCV2961267 rs1476714 0.9 1 hCV2961252 rs10067895 hCV2961268 rs2108425 0.9 1 hCV2961252 rs10067895 hCV2961269 rs2158958 0.9 1 hCV2961252 rs10067895 hCV2961270 rs9327555 0.9 1 hCV2961252 rs10067895 hCV2961278 rs7446891 0.9 1 hCV2961252 rs10067895 hCV2961280 rs10520072 0.9 1 hCV2961252 rs10067895 hCV2961282 rs917295 0.9 1 hCV2961252 rs10067895 hCV2961284 rs10054055 0.9 0.9616 hCV2961252 rs10067895 hCV2961296 rs10051148 0.9 0.9623 hCV2961252 rs10067895 hCV2961297 rs2158961 0.9 0.9634 hCV2961252 rs10067895 hCV2961306 rs264129 0.9 0.9232 hCV2961252 rs10067895 hCV30621656 rs10478919 0.9 0.927 hCV2961252 rs10067895 hCV31237567 rs11749272 0.9 0.927 hCV2961252 rs10067895 hCV346713 rs1990023 0.9 0.9232 hCV2961252 rs10067895 hCV546489 rs264122 0.9 0.9616 hCV2961252 rs10067895 hCV8932829 rs1116596 0.9 0.927 hCV2961253 rs2190600 hCV11819780 rs12153185 0.9 1 hCV2961253 rs2190600 hCV11819782 rs12719415 0.9 1 hCV2961253 rs2190600 hCV2575318 rs7711358 0.9 0.927 hCV2961253 rs2190600 hCV2575336 rs2418541 0.9 0.927 hCV2961253 rs2190600 hCV2575340 rs11242020 0.9 0.927 hCV2961253 rs2190600 hCV26478744 rs2016194 0.9 0.9198 hCV2961253 rs2190600 hCV26478745 rs2108426 0.9 0.9135 hCV2961253 rs2190600 hCV26478747 rs2190598 0.9 1 hCV2961253 rs2190600 hCV26478763 rs2418542 0.9 0.927 hCV2961253 rs2190600 hCV27996154 rs4836502 0.9 1 hCV2961253 rs2190600 hCV2961244 rs2418548 0.9 1 hCV2961253 rs2190600 hCV2961250 rs4836507 0.9 1 hCV2961253 rs2190600 hCV2961252 rs10067895 0.9 1 hCV2961253 rs2190600 hCV2961259 rs11242023 0.9 0.9621 hCV2961253 rs2190600 hCV2961260 rs11242022 0.9 1 hCV2961253 rs2190600 hCV2961261 rs11242021 0.9 1 hCV2961253 rs2190600 hCV2961267 rs1476714 0.9 1 hCV2961253 rs2190600 hCV2961268 rs2108425 0.9 1 hCV2961253 rs2190600 hCV2961269 rs2158958 0.9 1 hCV2961253 rs2190600 hCV2961270 rs9327555 0.9 1 hCV2961253 rs2190600 hCV2961278 rs7446891 0.9 1 hCV2961253 rs2190600 hCV2961280 rs10520072 0.9 1 hCV2961253 rs2190600 hCV2961282 rs917295 0.9 1 hCV2961253 rs2190600 hCV2961284 rs10054055 0.9 0.9616 hCV2961253 rs2190600 hCV2961296 rs10051148 0.9 0.9623 hCV2961253 rs2190600 hCV2961297 rs2158961 0.9 0.9634 hCV2961253 rs2190600 hCV2961306 rs264129 0.9 0.9232 hCV2961253 rs2190600 hCV30621656 rs10478919 0.9 0.927 hCV2961253 rs2190600 hCV31237567 rs11749272 0.9 0.927 hCV2961253 rs2190600 hCV346713 rs1990023 0.9 0.9232 hCV2961253 rs2190600 hCV546489 rs264122 0.9 0.9616 hCV2961253 rs2190600 hCV8932829 rs1116596 0.9 0.927 hCV2961259 rs11242023 hCV11819780 rs12153185 0.9 0.9571 hCV2961259 rs11242023 hCV11819782 rs12719415 0.9 0.9621 hCV2961259 rs11242023 hCV26478744 rs2016194 0.9 0.9587 hCV2961259 rs11242023 hCV26478745 rs2108426 0.9 0.9557 hCV2961259 rs11242023 hCV26478747 rs2190598 0.9 0.9604 hCV2961259 rs11242023 hCV27996154 rs4836502 0.9 0.9621 hCV2961259 rs11242023 hCV2961244 rs2418548 0.9 0.9571 hCV2961259 rs11242023 hCV2961250 rs4836507 0.9 0.9621 hCV2961259 rs11242023 hCV2961252 rs10067895 0.9 0.9621 hCV2961259 rs11242023 hCV2961253 rs2190600 0.9 0.9621 hCV2961259 rs11242023 hCV2961260 rs11242022 0.9 0.9785 hCV2961259 rs11242023 hCV2961261 rs11242021 0.9 0.9613 hCV2961259 rs11242023 hCV2961267 rs1476714 0.9 0.9592 hCV2961259 rs11242023 hCV2961268 rs2108425 0.9 0.9621 hCV2961259 rs11242023 hCV2961269 rs2158958 0.9 0.9621 hCV2961259 rs11242023 hCV2961270 rs9327555 0.9 0.9621 hCV2961259 rs11242023 hCV2961278 rs7446891 0.9 0.9621 hCV2961259 rs11242023 hCV2961280 rs10520072 0.9 0.9621 hCV2961259 rs11242023 hCV2961282 rs917295 0.9 0.9621 hCV2961259 rs11242023 hCV2961284 rs10054055 0.9 0.9573 hCV2961259 rs11242023 hCV2961296 rs10051148 0.9 0.9236 hCV2961259 rs11242023 hCV2961297 rs2158961 0.9 0.9252 hCV2961259 rs11242023 hCV2961306 rs264129 0.9 0.9358 hCV2961259 rs11242023 hCV346713 rs1990023 0.9 0.9358 hCV2961259 rs11242023 hCV546489 rs264122 0.9 0.9573 hCV2961260 rs11242022 hCV11819780 rs12153185 0.9 0.9785 hCV2961260 rs11242022 hCV11819782 rs12719415 0.9 1 hCV2961260 rs11242022 hCV2575318 rs7711358 0.9 0.9232 hCV2961260 rs11242022 hCV2575336 rs2418541 0.9 0.9232 hCV2961260 rs11242022 hCV2575340 rs11242020 0.9 0.9232 hCV2961260 rs11242022 hCV26478744 rs2016194 0.9 1 hCV2961260 rs11242022 hCV26478745 rs2108426 0.9 1 hCV2961260 rs11242022 hCV26478747 rs2190598 0.9 1 hCV2961260 rs11242022 hCV26478763 rs2418542 0.9 0.9232 hCV2961260 rs11242022 hCV27996154 rs4836502 0.9 1 hCV2961260 rs11242022 hCV2961244 rs2418548 0.9 0.9785 hCV2961260 rs11242022 hCV2961250 rs4836507 0.9 1 hCV2961260 rs11242022 hCV2961252 rs10067895 0.9 1 hCV2961260 rs11242022 hCV2961253 rs2190600 0.9 1 hCV2961260 rs11242022 hCV2961259 rs11242023 0.9 0.9785 hCV2961260 rs11242022 hCV2961261 rs11242021 0.9 1 hCV2961260 rs11242022 hCV2961267 rs1476714 0.9 1 hCV2961260 rs11242022 hCV2961268 rs2108425 0.9 1 hCV2961260 rs11242022 hCV2961269 rs2158958 0.9 1 hCV2961260 rs11242022 hCV2961270 rs9327555 0.9 1 hCV2961260 rs11242022 hCV2961278 rs7446891 0.9 1 hCV2961260 rs11242022 hCV2961280 rs10520072 0.9 1 hCV2961260 rs11242022 hCV2961282 rs917295 0.9 1 hCV2961260 rs11242022 hCV2961284 rs10054055 0.9 0.9783 hCV2961260 rs11242022 hCV2961296 rs10051148 0.9 0.9608 hCV2961260 rs11242022 hCV2961297 rs2158961 0.9 0.9616 hCV2961260 rs11242022 hCV2961306 rs264129 0.9 0.9567 hCV2961260 rs11242022 hCV30621656 rs10478919 0.9 0.9232 hCV2961260 rs11242022 hCV31237567 rs11749272 0.9 0.9232 hCV2961260 rs11242022 hCV346713 rs1990023 0.9 0.9567 hCV2961260 rs11242022 hCV546489 rs264122 0.9 0.9783 hCV2961260 rs11242022 hCV8932829 rs1116596 0.9 0.9232 hCV2961261 rs11242021 hCV11819780 rs12153185 0.9 1 hCV2961261 rs11242021 hCV11819782 rs12719415 0.9 1 hCV2961261 rs11242021 hCV2575318 rs7711358 0.9 0.9255 hCV2961261 rs11242021 hCV2575336 rs2418541 0.9 0.9255 hCV2961261 rs11242021 hCV2575340 rs11242020 0.9 0.9255 hCV2961261 rs11242021 hCV26478744 rs2016194 0.9 0.9198 hCV2961261 rs11242021 hCV26478745 rs2108426 0.9 0.9135 hCV2961261 rs11242021 hCV26478747 rs2190598 0.9 1 hCV2961261 rs11242021 hCV26478763 rs2418542 0.9 0.9255 hCV2961261 rs11242021 hCV27996154 rs4836502 0.9 1 hCV2961261 rs11242021 hCV2961244 rs2418548 0.9 1 hCV2961261 rs11242021 hCV2961250 rs4836507 0.9 1 hCV2961261 rs11242021 hCV2961252 rs10067895 0.9 1 hCV2961261 rs11242021 hCV2961253 rs2190600 0.9 1 hCV2961261 rs11242021 hCV2961259 rs11242023 0.9 0.9613 hCV2961261 rs11242021 hCV2961260 rs11242022 0.9 1 hCV2961261 rs11242021 hCV2961267 rs1476714 0.9 1 hCV2961261 rs11242021 hCV2961268 rs2108425 0.9 1 hCV2961261 rs11242021 hCV2961269 rs2158958 0.9 1 hCV2961261 rs11242021 hCV2961270 rs9327555 0.9 1 hCV2961261 rs11242021 hCV2961278 rs7446891 0.9 1 hCV2961261 rs11242021 hCV2961280 rs10520072 0.9 1 hCV2961261 rs11242021 hCV2961282 rs917295 0.9 1 hCV2961261 rs11242021 hCV2961284 rs10054055 0.9 0.9608 hCV2961261 rs11242021 hCV2961296 rs10051148 0.9 0.9615 hCV2961261 rs11242021 hCV2961297 rs2158961 0.9 0.9627 hCV2961261 rs11242021 hCV2961306 rs264129 0.9 0.9216 hCV2961261 rs11242021 hCV30621656 rs10478919 0.9 0.9255 hCV2961261 rs11242021 hCV31237567 rs11749272 0.9 0.9255 hCV2961261 rs11242021 hCV346713 rs1990023 0.9 0.9216 hCV2961261 rs11242021 hCV546489 rs264122 0.9 0.9608 hCV2961261 rs11242021 hCV8932829 rs1116596 0.9 0.9255 hCV2961267 rs1476714 hCV11819780 rs12153185 0.9 1 hCV2961267 rs1476714 hCV11819782 rs12719415 0.9 1 hCV2961267 rs1476714 hCV2575318 rs7711358 0.9 0.9607 hCV2961267 rs1476714 hCV2575336 rs2418541 0.9 0.9607 hCV2961267 rs1476714 hCV2575340 rs11242020 0.9 0.9607 hCV2961267 rs1476714 hCV26478744 rs2016194 0.9 0.9152 hCV2961267 rs1476714 hCV26478745 rs2108426 0.9 0.9081 hCV2961267 rs1476714 hCV26478747 rs2190598 0.9 1 hCV2961267 rs1476714 hCV26478763 rs2418542 0.9 0.9607 hCV2961267 rs1476714 hCV27996154 rs4836502 0.9 1 hCV2961267 rs1476714 hCV2961244 rs2418548 0.9 1 hCV2961267 rs1476714 hCV2961250 rs4836507 0.9 1 hCV2961267 rs1476714 hCV2961252 rs10067895 0.9 1 hCV2961267 rs1476714 hCV2961253 rs2190600 0.9 1 hCV2961267 rs1476714 hCV2961259 rs11242023 0.9 0.9592 hCV2961267 rs1476714 hCV2961260 rs11242022 0.9 1 hCV2961267 rs1476714 hCV2961261 rs11242021 0.9 1 hCV2961267 rs1476714 hCV2961268 rs2108425 0.9 1 hCV2961267 rs1476714 hCV2961269 rs2158958 0.9 1 hCV2961267 rs1476714 hCV2961270 rs9327555 0.9 1 hCV2961267 rs1476714 hCV2961278 rs7446891 0.9 1 hCV2961267 rs1476714 hCV2961280 rs10520072 0.9 1 hCV2961267 rs1476714 hCV2961282 rs917295 0.9 1 hCV2961267 rs1476714 hCV2961284 rs10054055 0.9 0.9587 hCV2961267 rs1476714 hCV2961296 rs10051148 0.9 0.9595 hCV2961267 rs1476714 hCV2961297 rs2158961 0.9 0.9607 hCV2961267 rs1476714 hCV2961306 rs264129 0.9 0.9172 hCV2961267 rs1476714 hCV30621656 rs10478919 0.9 0.9607 hCV2961267 rs1476714 hCV31237567 rs11749272 0.9 0.9607 hCV2961267 rs1476714 hCV346713 rs1990023 0.9 0.9587 hCV2961267 rs1476714 hCV546489 rs264122 0.9 0.9587 hCV2961267 rs1476714 hCV8932829 rs1116596 0.9 0.9607 hCV2961268 rs2108425 hCV11819780 rs12153185 0.9 1 hCV2961268 rs2108425 hCV11819782 rs12719415 0.9 1 hCV2961268 rs2108425 hCV2575318 rs7711358 0.9 0.927 hCV2961268 rs2108425 hCV2575336 rs2418541 0.9 0.927 hCV2961268 rs2108425 hCV2575340 rs11242020 0.9 0.927 hCV2961268 rs2108425 hCV26478744 rs2016194 0.9 0.9198 hCV2961268 rs2108425 hCV26478745 rs2108426 0.9 0.9135 hCV2961268 rs2108425 hCV26478747 rs2190598 0.9 1 hCV2961268 rs2108425 hCV26478763 rs2418542 0.9 0.927 hCV2961268 rs2108425 hCV27996154 rs4836502 0.9 1 hCV2961268 rs2108425 hCV2961244 rs2418548 0.9 1 hCV2961268 rs2108425 hCV2961250 rs4836507 0.9 1 hCV2961268 rs2108425 hCV2961252 rs10067895 0.9 1 hCV2961268 rs2108425 hCV2961253 rs2190600 0.9 1 hCV2961268 rs2108425 hCV2961259 rs11242023 0.9 0.9621 hCV2961268 rs2108425 hCV2961260 rs11242022 0.9 1 hCV2961268 rs2108425 hCV2961261 rs11242021 0.9 1 hCV2961268 rs2108425 hCV2961267 rs1476714 0.9 1 hCV2961268 rs2108425 hCV2961269 rs2158958 0.9 1 hCV2961268 rs2108425 hCV2961270 rs9327555 0.9 1 hCV2961268 rs2108425 hCV2961278 rs7446891 0.9 1 hCV2961268 rs2108425 hCV2961280 rs10520072 0.9 1 hCV2961268 rs2108425 hCV2961282 rs917295 0.9 1 hCV2961268 rs2108425 hCV2961284 rs10054055 0.9 0.9616 hCV2961268 rs2108425 hCV2961296 rs10051148 0.9 0.9623 hCV2961268 rs2108425 hCV2961297 rs2158961 0.9 0.9634 hCV2961268 rs2108425 hCV2961306 rs264129 0.9 0.9232 hCV2961268 rs2108425 hCV30621656 rs10478919 0.9 0.927 hCV2961268 rs2108425 hCV31237567 rs11749272 0.9 0.927 hCV2961268 rs2108425 hCV346713 rs1990023 0.9 0.9232 hCV2961268 rs2108425 hCV546489 rs264122 0.9 0.9616 hCV2961268 rs2108425 hCV8932829 rs1116596 0.9 0.927 hCV2961269 rs2158958 hCV11819780 rs12153185 0.9 1 hCV2961269 rs2158958 hCV11819782 rs12719415 0.9 1 hCV2961269 rs2158958 hCV2575318 rs7711358 0.9 0.927 hCV2961269 rs2158958 hCV2575336 rs2418541 0.9 0.927 hCV2961269 rs2158958 hCV2575340 rs11242020 0.9 0.927 hCV2961269 rs2158958 hCV26478744 rs2016194 0.9 0.9198 hCV2961269 rs2158958 hCV26478745 rs2108426 0.9 0.9135 hCV2961269 rs2158958 hCV26478747 rs2190598 0.9 1 hCV2961269 rs2158958 hCV26478763 rs2418542 0.9 0.927 hCV2961269 rs2158958 hCV27996154 rs4836502 0.9 1 hCV2961269 rs2158958 hCV2961244 rs2418548 0.9 1 hCV2961269 rs2158958 hCV2961250 rs4836507 0.9 1 hCV2961269 rs2158958 hCV2961252 rs10067895 0.9 1 hCV2961269 rs2158958 hCV2961253 rs2190600 0.9 1 hCV2961269 rs2158958 hCV2961259 rs11242023 0.9 0.9621 hCV2961269 rs2158958 hCV2961260 rs11242022 0.9 1 hCV2961269 rs2158958 hCV2961261 rs11242021 0.9 1 hCV2961269 rs2158958 hCV2961267 rs1476714 0.9 1 hCV2961269 rs2158958 hCV2961268 rs2108425 0.9 1 hCV2961269 rs2158958 hCV2961270 rs9327555 0.9 1 hCV2961269 rs2158958 hCV2961278 rs7446891 0.9 1 hCV2961269 rs2158958 hCV2961280 rs10520072 0.9 1 hCV2961269 rs2158958 hCV2961282 rs917295 0.9 1 hCV2961269 rs2158958 hCV2961284 rs10054055 0.9 0.9616 hCV2961269 rs2158958 hCV2961296 rs10051148 0.9 0.9623 hCV2961269 rs2158958 hCV2961297 rs2158961 0.9 0.9634 hCV2961269 rs2158958 hCV2961306 rs264129 0.9 0.9232 hCV2961269 rs2158958 hCV30621656 rs10478919 0.9 0.927 hCV2961269 rs2158958 hCV31237567 rs11749272 0.9 0.927 hCV2961269 rs2158958 hCV346713 rs1990023 0.9 0.9232 hCV2961269 rs2158958 hCV546489 rs264122 0.9 0.9616 hCV2961269 rs2158958 hCV8932829 rs1116596 0.9 0.927 hCV2961270 rs9327555 hCV11819780 rs12153185 0.9 1 hCV2961270 rs9327555 hCV11819782 rs12719415 0.9 1 hCV2961270 rs9327555 hCV2575318 rs7711358 0.9 0.927 hCV2961270 rs9327555 hCV2575336 rs2418541 0.9 0.927 hCV2961270 rs9327555 hCV2575340 rs11242020 0.9 0.927 hCV2961270 rs9327555 hCV26478744 rs2016194 0.9 0.9198 hCV2961270 rs9327555 hCV26478745 rs2108426 0.9 0.9135 hCV2961270 rs9327555 hCV26478747 rs2190598 0.9 1 hCV2961270 rs9327555 hCV26478763 rs2418542 0.9 0.927 hCV2961270 rs9327555 hCV27996154 rs4836502 0.9 1 hCV2961270 rs9327555 hCV2961244 rs2418548 0.9 1 hCV2961270 rs9327555 hCV2961250 rs4836507 0.9 1 hCV2961270 rs9327555 hCV2961252 rs10067895 0.9 1 hCV2961270 rs9327555 hCV2961253 rs2190600 0.9 1 hCV2961270 rs9327555 hCV2961259 rs11242023 0.9 0.9621 hCV2961270 rs9327555 hCV2961260 rs11242022 0.9 1 hCV2961270 rs9327555 hCV2961261 rs11242021 0.9 1 hCV2961270 rs9327555 hCV2961267 rs1476714 0.9 1 hCV2961270 rs9327555 hCV2961268 rs2108425 0.9 1 hCV2961270 rs9327555 hCV2961269 rs2158958 0.9 1 hCV2961270 rs9327555 hCV2961278 rs7446891 0.9 1 hCV2961270 rs9327555 hCV2961280 rs10520072 0.9 1 hCV2961270 rs9327555 hCV2961282 rs917295 0.9 1 hCV2961270 rs9327555 hCV2961284 rs10054055 0.9 0.9616 hCV2961270 rs9327555 hCV2961296 rs10051148 0.9 0.9623 hCV2961270 rs9327555 hCV2961297 rs2158961 0.9 0.9634 hCV2961270 rs9327555 hCV2961306 rs264129 0.9 0.9232 hCV2961270 rs9327555 hCV30621656 rs10478919 0.9 0.927 hCV2961270 rs9327555 hCV31237567 rs11749272 0.9 0.927 hCV2961270 rs9327555 hCV346713 rs1990023 0.9 0.9232 hCV2961270 rs9327555 hCV546489 rs264122 0.9 0.9616 hCV2961270 rs9327555 hCV8932829 rs1116596 0.9 0.927 hCV2961278 rs7446891 hCV11819780 rs12153185 0.9 1 hCV2961278 rs7446891 hCV11819782 rs12719415 0.9 1 hCV2961278 rs7446891 hCV2575318 rs7711358 0.9 0.927 hCV2961278 rs7446891 hCV2575336 rs2418541 0.9 0.927 hCV2961278 rs7446891 hCV2575340 rs11242020 0.9 0.927 hCV2961278 rs7446891 hCV26478744 rs2016194 0.9 0.9198 hCV2961278 rs7446891 hCV26478745 rs2108426 0.9 0.9135 hCV2961278 rs7446891 hCV26478747 rs2190598 0.9 1 hCV2961278 rs7446891 hCV26478763 rs2418542 0.9 0.927 hCV2961278 rs7446891 hCV27996154 rs4836502 0.9 1 hCV2961278 rs7446891 hCV2961244 rs2418548 0.9 1 hCV2961278 rs7446891 hCV2961250 rs4836507 0.9 1 hCV2961278 rs7446891 hCV2961252 rs10067895 0.9 1 hCV2961278 rs7446891 hCV2961253 rs2190600 0.9 1 hCV2961278 rs7446891 hCV2961259 rs11242023 0.9 0.9621 hCV2961278 rs7446891 hCV2961260 rs11242022 0.9 1 hCV2961278 rs7446891 hCV2961261 rs11242021 0.9 1 hCV2961278 rs7446891 hCV2961267 rs1476714 0.9 1 hCV2961278 rs7446891 hCV2961268 rs2108425 0.9 1 hCV2961278 rs7446891 hCV2961269 rs2158958 0.9 1 hCV2961278 rs7446891 hCV2961270 rs9327555 0.9 1 hCV2961278 rs7446891 hCV2961280 rs10520072 0.9 1 hCV2961278 rs7446891 hCV2961282 rs917295 0.9 1 hCV2961278 rs7446891 hCV2961284 rs10054055 0.9 0.9616 hCV2961278 rs7446891 hCV2961296 rs10051148 0.9 0.9623 hCV2961278 rs7446891 hCV2961297 rs2158961 0.9 0.9634 hCV2961278 rs7446891 hCV2961306 rs264129 0.9 0.9232 hCV2961278 rs7446891 hCV30621656 rs10478919 0.9 0.927 hCV2961278 rs7446891 hCV31237567 rs11749272 0.9 0.927 hCV2961278 rs7446891 hCV346713 rs1990023 0.9 0.9232 hCV2961278 rs7446891 hCV546489 rs264122 0.9 0.9616 hCV2961278 rs7446891 hCV8932829 rs1116596 0.9 0.927 hCV2961280 rs10520072 hCV11819780 rs12153185 0.9 1 hCV2961280 rs10520072 hCV11819782 rs12719415 0.9 1 hCV2961280 rs10520072 hCV2575318 rs7711358 0.9 0.927 hCV2961280 rs10520072 hCV2575336 rs2418541 0.9 0.927 hCV2961280 rs10520072 hCV2575340 rs11242020 0.9 0.927 hCV2961280 rs10520072 hCV26478744 rs2016194 0.9 0.9198 hCV2961280 rs10520072 hCV26478745 rs2108426 0.9 0.9135 hCV2961280 rs10520072 hCV26478747 rs2190598 0.9 1 hCV2961280 rs10520072 hCV26478763 rs2418542 0.9 0.927 hCV2961280 rs10520072 hCV27996154 rs4836502 0.9 1 hCV2961280 rs10520072 hCV2961244 rs2418548 0.9 1 hCV2961280 rs10520072 hCV2961250 rs4836507 0.9 1 hCV2961280 rs10520072 hCV2961252 rs10067895 0.9 1 hCV2961280 rs10520072 hCV2961253 rs2190600 0.9 1 hCV2961280 rs10520072 hCV2961259 rs11242023 0.9 0.9621 hCV2961280 rs10520072 hCV2961260 rs11242022 0.9 1 hCV2961280 rs10520072 hCV2961261 rs11242021 0.9 1 hCV2961280 rs10520072 hCV2961267 rs1476714 0.9 1 hCV2961280 rs10520072 hCV2961268 rs2108425 0.9 1 hCV2961280 rs10520072 hCV2961269 rs2158958 0.9 1 hCV2961280 rs10520072 hCV2961270 rs9327555 0.9 1 hCV2961280 rs10520072 hCV2961278 rs7446891 0.9 1 hCV2961280 rs10520072 hCV2961282 rs917295 0.9 1 hCV2961280 rs10520072 hCV2961284 rs10054055 0.9 0.9616 hCV2961280 rs10520072 hCV2961296 rs10051148 0.9 0.9623 hCV2961280 rs10520072 hCV2961297 rs2158961 0.9 0.9634 hCV2961280 rs10520072 hCV2961306 rs264129 0.9 0.9232 hCV2961280 rs10520072 hCV30621656 rs10478919 0.9 0.927 hCV2961280 rs10520072 hCV31237567 rs11749272 0.9 0.927 hCV2961280 rs10520072 hCV346713 rs1990023 0.9 0.9232 hCV2961280 rs10520072 hCV546489 rs264122 0.9 0.9616 hCV2961280 rs10520072 hCV8932829 rs1116596 0.9 0.927 hCV2961282 rs917295 hCV11819780 rs12153185 0.9 1 hCV2961282 rs917295 hCV11819782 rs12719415 0.9 1 hCV2961282 rs917295 hCV2575318 rs7711358 0.9 0.927 hCV2961282 rs917295 hCV2575336 rs2418541 0.9 0.927 hCV2961282 rs917295 hCV2575340 rs11242020 0.9 0.927 hCV2961282 rs917295 hCV26478744 rs2016194 0.9 0.9197 hCV2961282 rs917295 hCV26478745 rs2108426 0.9 0.9134 hCV2961282 rs917295 hCV26478747 rs2190598 0.9 1 hCV2961282 rs917295 hCV26478763 rs2418542 0.9 0.927 hCV2961282 rs917295 hCV27996154 rs4836502 0.9 1 hCV2961282 rs917295 hCV2961244 rs2418548 0.9 1 hCV2961282 rs917295 hCV2961250 rs4836507 0.9 1 hCV2961282 rs917295 hCV2961252 rs10067895 0.9 1 hCV2961282 rs917295 hCV2961253 rs2190600 0.9 1 hCV2961282 rs917295 hCV2961259 rs11242023 0.9 0.9621 hCV2961282 rs917295 hCV2961260 rs11242022 0.9 1 hCV2961282 rs917295 hCV2961261 rs11242021 0.9 1 hCV2961282 rs917295 hCV2961267 rs1476714 0.9 1 hCV2961282 rs917295 hCV2961268 rs2108425 0.9 1 hCV2961282 rs917295 hCV2961269 rs2158958 0.9 1 hCV2961282 rs917295 hCV2961270 rs9327555 0.9 1 hCV2961282 rs917295 hCV2961278 rs7446891 0.9 1 hCV2961282 rs917295 hCV2961280 rs10520072 0.9 1 hCV2961282 rs917295 hCV2961284 rs10054055 0.9 0.9616 hCV2961282 rs917295 hCV2961296 rs10051148 0.9 0.9623 hCV2961282 rs917295 hCV2961297 rs2158961 0.9 0.9634 hCV2961282 rs917295 hCV2961306 rs264129 0.9 0.9232 hCV2961282 rs917295 hCV30621656 rs10478919 0.9 0.927 hCV2961282 rs917295 hCV31237567 rs11749272 0.9 0.927 hCV2961282 rs917295 hCV346713 rs1990023 0.9 0.9232 hCV2961282 rs917295 hCV546489 rs264122 0.9 0.9616 hCV2961282 rs917295 hCV8932829 rs1116596 0.9 0.927 hCV2961284 rs10054055 hCV11819780 rs12153185 0.9 0.9573 hCV2961284 rs10054055 hCV11819782 rs12719415 0.9 0.9616 hCV2961284 rs10054055 hCV2575318 rs7711358 0.9 0.9616 hCV2961284 rs10054055 hCV2575336 rs2418541 0.9 0.9616 hCV2961284 rs10054055 hCV2575340 rs11242020 0.9 0.9616 hCV2961284 rs10054055 hCV26478744 rs2016194 0.9 0.9581 hCV2961284 rs10054055 hCV26478745 rs2108426 0.9 1 hCV2961284 rs10054055 hCV26478747 rs2190598 0.9 0.96 hCV2961284 rs10054055 hCV26478763 rs2418542 0.9 0.9616 hCV2961284 rs10054055 hCV27996154 rs4836502 0.9 0.9616 hCV2961284 rs10054055 hCV2961244 rs2418548 0.9 0.9573 hCV2961284 rs10054055 hCV2961250 rs4836507 0.9 0.9616 hCV2961284 rs10054055 hCV2961252 rs10067895 0.9 0.9616 hCV2961284 rs10054055 hCV2961253 rs2190600 0.9 0.9616 hCV2961284 rs10054055 hCV2961259 rs11242023 0.9 0.9573 hCV2961284 rs10054055 hCV2961260 rs11242022 0.9 0.9783 hCV2961284 rs10054055 hCV2961261 rs11242021 0.9 0.9608 hCV2961284 rs10054055 hCV2961267 rs1476714 0.9 0.9587 hCV2961284 rs10054055 hCV2961268 rs2108425 0.9 0.9616 hCV2961284 rs10054055 hCV2961269 rs2158958 0.9 0.9616 hCV2961284 rs10054055 hCV2961270 rs9327555 0.9 0.9616 hCV2961284 rs10054055 hCV2961278 rs7446891 0.9 0.9616 hCV2961284 rs10054055 hCV2961280 rs10520072 0.9 0.9616 hCV2961284 rs10054055 hCV2961282 rs917295 0.9 0.9616 hCV2961284 rs10054055 hCV2961296 rs10051148 0.9 1 hCV2961284 rs10054055 hCV2961297 rs2158961 0.9 1 hCV2961284 rs10054055 hCV2961306 rs264129 0.9 0.9783 hCV2961284 rs10054055 hCV29666186 rs6871041 0.9 0.9189 hCV2961284 rs10054055 hCV30621656 rs10478919 0.9 0.9616 hCV2961284 rs10054055 hCV31237567 rs11749272 0.9 0.9616 hCV2961284 rs10054055 hCV346713 rs1990023 0.9 0.9783 hCV2961284 rs10054055 hCV546489 rs264122 0.9 1 hCV2961284 rs10054055 hCV8932829 rs1116596 0.9 0.9616 hCV2961296 rs10051148 hCV11819780 rs12153185 0.9 0.9608 hCV2961296 rs10051148 hCV11819782 rs12719415 0.9 0.9623 hCV2961296 rs10051148 hCV2575318 rs7711358 0.9 0.9623 hCV2961296 rs10051148 hCV2575336 rs2418541 0.9 0.9623 hCV2961296 rs10051148 hCV2575340 rs11242020 0.9 0.9623 hCV2961296 rs10051148 hCV26478744 rs2016194 0.9 0.9589 hCV2961296 rs10051148 hCV26478745 rs2108426 0.9 1 hCV2961296 rs10051148 hCV26478747 rs2190598 0.9 0.9615 hCV2961296 rs10051148 hCV26478763 rs2418542 0.9 0.9623 hCV2961296 rs10051148 hCV27996154 rs4836502 0.9 0.9623 hCV2961296 rs10051148 hCV2961244 rs2418548 0.9 0.9608 hCV2961296 rs10051148 hCV2961250 rs4836507 0.9 0.9623 hCV2961296 rs10051148 hCV2961252 rs10067895 0.9 0.9623 hCV2961296 rs10051148 hCV2961253 rs2190600 0.9 0.9623 hCV2961296 rs10051148 hCV2961259 rs11242023 0.9 0.9236 hCV2961296 rs10051148 hCV2961260 rs11242022 0.9 0.9608 hCV2961296 rs10051148 hCV2961261 rs11242021 0.9 0.9615 hCV2961296 rs10051148 hCV2961267 rs1476714 0.9 0.9595 hCV2961296 rs10051148 hCV2961268 rs2108425 0.9 0.9623 hCV2961296 rs10051148 hCV2961269 rs2158958 0.9 0.9623 hCV2961296 rs10051148 hCV2961270 rs9327555 0.9 0.9623 hCV2961296 rs10051148 hCV2961278 rs7446891 0.9 0.9623 hCV2961296 rs10051148 hCV2961280 rs10520072 0.9 0.9623 hCV2961296 rs10051148 hCV2961282 rs917295 0.9 0.9623 hCV2961296 rs10051148 hCV2961284 rs10054055 0.9 1 hCV2961296 rs10051148 hCV2961297 rs2158961 0.9 1 hCV2961296 rs10051148 hCV2961306 rs264129 0.9 0.9608 hCV2961296 rs10051148 hCV29666186 rs6871041 0.9 0.9202 hCV2961296 rs10051148 hCV30621656 rs10478919 0.9 0.9623 hCV2961296 rs10051148 hCV31237567 rs11749272 0.9 0.9623 hCV2961296 rs10051148 hCV346713 rs1990023 0.9 0.9608 hCV2961296 rs10051148 hCV546489 rs264122 0.9 1 hCV2961296 rs10051148 hCV8932829 rs1116596 0.9 0.9623 hCV2961297 rs2158961 hCV11819780 rs12153185 0.9 0.9616 hCV2961297 rs2158961 hCV11819782 rs12719415 0.9 0.9634 hCV2961297 rs2158961 hCV2575318 rs7711358 0.9 0.9634 hCV2961297 rs2158961 hCV2575336 rs2418541 0.9 0.9634 hCV2961297 rs2158961 hCV2575340 rs11242020 0.9 0.9634 hCV2961297 rs2158961 hCV26478745 rs2108426 0.9 0.9135 hCV2961297 rs2158961 hCV26478747 rs2190598 0.9 0.9619 hCV2961297 rs2158961 hCV26478763 rs2418542 0.9 0.9634 hCV2961297 rs2158961 hCV27996154 rs4836502 0.9 0.9634 hCV2961297 rs2158961 hCV2961244 rs2418548 0.9 0.9616 hCV2961297 rs2158961 hCV2961250 rs4836507 0.9 0.9634 hCV2961297 rs2158961 hCV2961252 rs10067895 0.9 0.9634 hCV2961297 rs2158961 hCV2961253 rs2190600 0.9 0.9634 hCV2961297 rs2158961 hCV2961259 rs11242023 0.9 0.9252 hCV2961297 rs2158961 hCV2961260 rs11242022 0.9 0.9616 hCV2961297 rs2158961 hCV2961261 rs11242021 0.9 0.9627 hCV2961297 rs2158961 hCV2961267 rs1476714 0.9 0.9607 hCV2961297 rs2158961 hCV2961268 rs2108425 0.9 0.9634 hCV2961297 rs2158961 hCV2961269 rs2158958 0.9 0.9634 hCV2961297 rs2158961 hCV2961270 rs9327555 0.9 0.9634 hCV2961297 rs2158961 hCV2961278 rs7446891 0.9 0.9634 hCV2961297 rs2158961 hCV2961280 rs10520072 0.9 0.9634 hCV2961297 rs2158961 hCV2961282 rs917295 0.9 0.9634 hCV2961297 rs2158961 hCV2961284 rs10054055 0.9 1 hCV2961297 rs2158961 hCV2961296 rs10051148 0.9 1 hCV2961297 rs2158961 hCV2961306 rs264129 0.9 0.9616 hCV2961297 rs2158961 hCV29666186 rs6871041 0.9 0.9226 hCV2961297 rs2158961 hCV30621656 rs10478919 0.9 0.9634 hCV2961297 rs2158961 hCV31237567 rs11749272 0.9 0.9634 hCV2961297 rs2158961 hCV346713 rs1990023 0.9 0.9616 hCV2961297 rs2158961 hCV546489 rs264122 0.9 1 hCV2961297 rs2158961 hCV8932829 rs1116596 0.9 0.9634 hCV2961306 rs264129 hCV11819780 rs12153185 0.9 0.9358 hCV2961306 rs264129 hCV11819782 rs12719415 0.9 0.9232 hCV2961306 rs264129 hCV2575318 rs7711358 0.9 0.9232 hCV2961306 rs264129 hCV2575336 rs2418541 0.9 0.9232 hCV2961306 rs264129 hCV2575340 rs11242020 0.9 0.9232 hCV2961306 rs264129 hCV26478744 rs2016194 0.9 0.9162 hCV2961306 rs264129 hCV26478745 rs2108426 0.9 0.9557 hCV2961306 rs264129 hCV26478747 rs2190598 0.9 0.9198 hCV2961306 rs264129 hCV26478763 rs2418542 0.9 0.9232 hCV2961306 rs264129 hCV27996154 rs4836502 0.9 0.9232 hCV2961306 rs264129 hCV2961244 rs2418548 0.9 0.9358 hCV2961306 rs264129 hCV2961250 rs4836507 0.9 0.9232 hCV2961306 rs264129 hCV2961252 rs10067895 0.9 0.9232 hCV2961306 rs264129 hCV2961253 rs2190600 0.9 0.9232 hCV2961306 rs264129 hCV2961259 rs11242023 0.9 0.9358 hCV2961306 rs264129 hCV2961260 rs11242022 0.9 0.9567 hCV2961306 rs264129 hCV2961261 rs11242021 0.9 0.9216 hCV2961306 rs264129 hCV2961267 rs1476714 0.9 0.9172 hCV2961306 rs264129 hCV2961268 rs2108425 0.9 0.9232 hCV2961306 rs264129 hCV2961269 rs2158958 0.9 0.9232 hCV2961306 rs264129 hCV2961270 rs9327555 0.9 0.9232 hCV2961306 rs264129 hCV2961278 rs7446891 0.9 0.9232 hCV2961306 rs264129 hCV2961280 rs10520072 0.9 0.9232 hCV2961306 rs264129 hCV2961282 rs917295 0.9 0.9232 hCV2961306 rs264129 hCV2961284 rs10054055 0.9 0.9783 hCV2961306 rs264129 hCV2961296 rs10051148 0.9 0.9608 hCV2961306 rs264129 hCV2961297 rs2158961 0.9 0.9616 hCV2961306 rs264129 hCV30621656 rs10478919 0.9 0.9232 hCV2961306 rs264129 hCV31237567 rs11749272 0.9 0.9232 hCV2961306 rs264129 hCV346713 rs1990023 0.9 0.9567 hCV2961306 rs264129 hCV546489 rs264122 0.9 0.9783 hCV2961306 rs264129 hCV8932829 rs1116596 0.9 0.9232 hCV29666186 rs6871041 hCV2961284 rs10054055 0.9 0.9189 hCV29666186 rs6871041 hCV2961296 rs10051148 0.9 0.9202 hCV29666186 rs6871041 hCV2961297 rs2158961 0.9 0.9226 hCV29666186 rs6871041 hCV546489 rs264122 0.9 0.9189 hCV29840965 rs6040644 hCV2529198 rs742827 0.9 0.9596 hCV29840965 rs6040644 hCV2529202 rs6040667 0.9 1 hCV29840965 rs6040644 hCV2529211 rs17189710 0.9 1 hCV29840965 rs6040644 hCV2529224 rs2327412 0.9 1 hCV29840965 rs6040644 hCV2529230 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hCV31587414 rs6746170 hCV31587415 rs6544728 0.9 1 hCV31587414 rs6746170 hCV31587430 rs11124962 0.9 0.9489 hCV31587415 rs6544728 hCV25642662 rs10190161 0.9 0.9224 hCV31587415 rs6544728 hCV31587413 rs6746182 0.9 1 hCV31587415 rs6544728 hCV31587414 rs6746170 0.9 1 hCV31587415 rs6544728 hCV31587430 rs11124962 0.9 0.9602 hCV31587430 rs11124962 hCV31587413 rs6746182 0.9 0.9489 hCV31587430 rs11124962 hCV31587414 rs6746170 0.9 0.9489 hCV31587430 rs11124962 hCV31587415 rs6544728 0.9 0.9602 hCV3172867 rs316720 hCV989588 rs669684 0.9 0.9626 hCV3172867 rs316720 hCV989658 rs647645 0.9 0.9631 hCV31931605 rs7022281 hCV27084860 rs10758326 0.9 0.9004 hCV31931605 rs7022281 hCV31931609 rs10738948 0.9 0.9289 hCV31931609 rs10738948 hCV27084860 rs10758326 0.9 0.9637 hCV31931609 rs10738948 hCV31931605 rs7022281 0.9 0.9289 hCV32014843 rs11221075 hCV1056544 rs675163 0.9 1 hCV32014843 rs11221075 hCV32014853 rs11221097 0.9 1 hCV32014843 rs11221075 hCV767324 rs687047 0.9 1 hCV32274419 rs13038146 hCV2529198 rs742827 0.9 0.9624 hCV32274419 rs13038146 hCV2529202 rs6040667 0.9 1 hCV32274419 rs13038146 hCV2529211 rs17189710 0.9 1 hCV32274419 rs13038146 hCV2529224 rs2327412 0.9 1 hCV32274419 rs13038146 hCV2529230 rs4444612 0.9 1 hCV32274419 rs13038146 hCV2529231 rs4315598 0.9 1 hCV32274419 rs13038146 hCV2529239 rs6040638 0.9 1 hCV32274419 rs13038146 hCV2529241 rs6134243 0.9 1 hCV32274419 rs13038146 hCV2529246 rs6040619 0.9 1 hCV32274419 rs13038146 hCV27367681 rs2876227 0.9 0.9649 hCV32274419 rs13038146 hCV27367708 rs1009748 0.9 1 hCV32274419 rs13038146 hCV29840965 rs6040644 0.9 1 hCV32274419 rs13038146 hCV30057061 rs6033138 0.9 1 hCV32274419 rs13038146 hCV30093270 rs6040625 0.9 1 hCV32274419 rs13038146 hCV30129243 rs6040636 0.9 1 hCV32274419 rs13038146 hCV30218977 rs6040633 0.9 1 hCV32274419 rs13038146 hCV30417550 rs6040634 0.9 1 hCV32274419 rs13038146 hCV30453433 rs6131208 0.9 0.9585 hCV32274419 rs13038146 hCV30615489 rs6040630 0.9 0.9294 hCV32274419 rs13038146 hCV330228 rs6040668 0.9 1 hCV330228 rs6040668 hCV2529198 rs742827 0.9 0.9624 hCV330228 rs6040668 hCV2529202 rs6040667 0.9 1 hCV330228 rs6040668 hCV2529211 rs17189710 0.9 1 hCV330228 rs6040668 hCV2529224 rs2327412 0.9 1 hCV330228 rs6040668 hCV2529230 rs4444612 0.9 1 hCV330228 rs6040668 hCV2529231 rs4315598 0.9 1 hCV330228 rs6040668 hCV2529239 rs6040638 0.9 1 hCV330228 rs6040668 hCV2529241 rs6134243 0.9 1 hCV330228 rs6040668 hCV2529246 rs6040619 0.9 1 hCV330228 rs6040668 hCV27367681 rs2876227 0.9 0.9649 hCV330228 rs6040668 hCV27367708 rs1009748 0.9 1 hCV330228 rs6040668 hCV29840965 rs6040644 0.9 1 hCV330228 rs6040668 hCV30057061 rs6033138 0.9 1 hCV330228 rs6040668 hCV30093270 rs6040625 0.9 1 hCV330228 rs6040668 hCV30129243 rs6040636 0.9 1 hCV330228 rs6040668 hCV30218977 rs6040633 0.9 1 hCV330228 rs6040668 hCV30417550 rs6040634 0.9 1 hCV330228 rs6040668 hCV30453433 rs6131208 0.9 0.9585 hCV330228 rs6040668 hCV30615489 rs6040630 0.9 0.9294 hCV330228 rs6040668 hCV32274419 rs13038146 0.9 1 hCV346713 rs1990023 hCV11819780 rs12153185 0.9 0.9358 hCV346713 rs1990023 hCV11819782 rs12719415 0.9 0.9232 hCV346713 rs1990023 hCV2575318 rs7711358 0.9 1 hCV346713 rs1990023 hCV2575336 rs2418541 0.9 1 hCV346713 rs1990023 hCV2575340 rs11242020 0.9 1 hCV346713 rs1990023 hCV26478744 rs2016194 0.9 0.9162 hCV346713 rs1990023 hCV26478745 rs2108426 0.9 0.9557 hCV346713 rs1990023 hCV26478747 rs2190598 0.9 0.9199 hCV346713 rs1990023 hCV26478763 rs2418542 0.9 1 hCV346713 rs1990023 hCV27996154 rs4836502 0.9 0.9232 hCV346713 rs1990023 hCV2961244 rs2418548 0.9 0.9358 hCV346713 rs1990023 hCV2961250 rs4836507 0.9 0.9232 hCV346713 rs1990023 hCV2961252 rs10067895 0.9 0.9232 hCV346713 rs1990023 hCV2961253 rs2190600 0.9 0.9232 hCV346713 rs1990023 hCV2961259 rs11242023 0.9 0.9358 hCV346713 rs1990023 hCV2961260 rs11242022 0.9 0.9567 hCV346713 rs1990023 hCV2961261 rs11242021 0.9 0.9216 hCV346713 rs1990023 hCV2961267 rs1476714 0.9 0.9587 hCV346713 rs1990023 hCV2961268 rs2108425 0.9 0.9232 hCV346713 rs1990023 hCV2961269 rs2158958 0.9 0.9232 hCV346713 rs1990023 hCV2961270 rs9327555 0.9 0.9232 hCV346713 rs1990023 hCV2961278 rs7446891 0.9 0.9232 hCV346713 rs1990023 hCV2961280 rs10520072 0.9 0.9232 hCV346713 rs1990023 hCV2961282 rs917295 0.9 0.9232 hCV346713 rs1990023 hCV2961284 rs10054055 0.9 0.9783 hCV346713 rs1990023 hCV2961296 rs10051148 0.9 0.9608 hCV346713 rs1990023 hCV2961297 rs2158961 0.9 0.9616 hCV346713 rs1990023 hCV2961306 rs264129 0.9 0.9567 hCV346713 rs1990023 hCV30621656 rs10478919 0.9 1 hCV346713 rs1990023 hCV31237567 rs11749272 0.9 1 hCV346713 rs1990023 hCV546489 rs264122 0.9 0.9783 hCV346713 rs1990023 hCV8932829 rs1116596 0.9 1 hCV349805 rs4851529 hCV16126066 rs2110564 0.9 0.9329 hCV349805 rs4851529 hCV2676440 rs6722640 0.9 0.9329 hCV349805 rs4851529 hCV27872026 rs4851531 0.9 0.9646 hCV349805 rs4851529 hCV8905894 rs974950 0.9 0.9303 hCV364260 rs2505039 hCV29557190 rs9487275 0.9 0.9632 hCV364260 rs2505039 hCV35209 rs4329143 0.9 0.9615 hCV364260 rs2505039 hCV364258 rs2505038 0.9 0.9806 hCV364260 rs2505039 hCV364261 rs7749240 0.9 0.9639 hCV375090 rs4450660 hCV26135665 rs4390811 0.9 0.96 hCV375090 rs4450660 hCV26771384 rs10865197 0.9 1 hCV375090 rs4450660 hCV26771389 rs10183431 0.9 1 hCV375090 rs4450660 hCV27875215 rs4346434 0.9 0.922 hCV375090 rs4450660 hCV27933339 rs4586678 0.9 1 hCV375090 rs4450660 hCV29229284 rs6741066 0.9 0.9591 hCV375090 rs4450660 hCV30817981 rs6723119 0.9 0.96 hCV375090 rs4450660 hCV375079 rs9309112 0.9 0.92 hCV375090 rs4450660 hCV375083 rs10206724 0.9 1 hCV375090 rs4450660 hCV514334 rs6544721 0.9 0.961 hCV443083 rs6742894 hCV48381 rs6743092 0.9 1 hCV443083 rs6742894 hCV48382 rs12465349 0.9 1 hCV48381 rs6743092 hCV443083 rs6742894 0.9 1 hCV48381 rs6743092 hCV48382 rs12465349 0.9 1 hCV514334 rs6544721 hCV25642662 rs10190161 0.9 0.9211 hCV514334 rs6544721 hCV26135665 rs4390811 0.9 0.9201 hCV514334 rs6544721 hCV26771384 rs10865197 0.9 0.961 hCV514334 rs6544721 hCV26771389 rs10183431 0.9 0.961 hCV514334 rs6544721 hCV27933339 rs4586678 0.9 0.961 hCV514334 rs6544721 hCV29229284 rs6741066 0.9 0.9183 hCV514334 rs6544721 hCV30817981 rs6723119 0.9 1 hCV514334 rs6544721 hCV375083 rs10206724 0.9 0.96 hCV514334 rs6544721 hCV375090 rs4450660 0.9 0.961 hCV546489 rs264122 hCV11819780 rs12153185 0.9 0.9573 hCV546489 rs264122 hCV11819782 rs12719415 0.9 0.9616 hCV546489 rs264122 hCV2575318 rs7711358 0.9 0.9616 hCV546489 rs264122 hCV2575336 rs2418541 0.9 0.9616 hCV546489 rs264122 hCV2575340 rs11242020 0.9 0.9616 hCV546489 rs264122 hCV26478744 rs2016194 0.9 0.9581 hCV546489 rs264122 hCV26478745 rs2108426 0.9 1 hCV546489 rs264122 hCV26478747 rs2190598 0.9 0.96 hCV546489 rs264122 hCV26478763 rs2418542 0.9 0.9616 hCV546489 rs264122 hCV27996154 rs4836502 0.9 0.9616 hCV546489 rs264122 hCV2961244 rs2418548 0.9 0.9573 hCV546489 rs264122 hCV2961250 rs4836507 0.9 0.9616 hCV546489 rs264122 hCV2961252 rs10067895 0.9 0.9616 hCV546489 rs264122 hCV2961253 rs2190600 0.9 0.9616 hCV546489 rs264122 hCV2961259 rs11242023 0.9 0.9573 hCV546489 rs264122 hCV2961260 rs11242022 0.9 0.9783 hCV546489 rs264122 hCV2961261 rs11242021 0.9 0.9608 hCV546489 rs264122 hCV2961267 rs1476714 0.9 0.9587 hCV546489 rs264122 hCV2961268 rs2108425 0.9 0.9616 hCV546489 rs264122 hCV2961269 rs2158958 0.9 0.9616 hCV546489 rs264122 hCV2961270 rs9327555 0.9 0.9616 hCV546489 rs264122 hCV2961278 rs7446891 0.9 0.9616 hCV546489 rs264122 hCV2961280 rs10520072 0.9 0.9616 hCV546489 rs264122 hCV2961282 rs917295 0.9 0.9616 hCV546489 rs264122 hCV2961284 rs10054055 0.9 1 hCV546489 rs264122 hCV2961296 rs10051148 0.9 1 hCV546489 rs264122 hCV2961297 rs2158961 0.9 1 hCV546489 rs264122 hCV2961306 rs264129 0.9 0.9783 hCV546489 rs264122 hCV29666186 rs6871041 0.9 0.9189 hCV546489 rs264122 hCV30621656 rs10478919 0.9 0.9616 hCV546489 rs264122 hCV31237567 rs11749272 0.9 0.9616 hCV546489 rs264122 hCV346713 rs1990023 0.9 0.9783 hCV546489 rs264122 hCV8932829 rs1116596 0.9 0.9616 hCV546493 rs264126 hCV2575337 rs2214640 0.9 1 hCV546493 rs264126 hCV2575344 rs10064779 0.9 0.9328 hCV546493 rs264126 hCV26478748 rs2190597 0.9 0.9328 hCV546493 rs264126 hCV29134277 rs6595948 0.9 0.9001 hCV546493 rs264126 hCV2961235 rs6869219 0.9 0.9255 hCV546493 rs264126 hCV2961239 rs6868888 0.9 0.9282 hCV546493 rs264126 hCV2961251 rs1157409 0.9 0.9328 hCV546493 rs264126 hCV8932783 rs1473132 0.9 0.9328 hCV767324 rs687047 hCV1056543 rs688358 0.9 1 hCV767324 rs687047 hCV1056544 rs675163 0.9 1 hCV767324 rs687047 hCV32014843 rs11221075 0.9 1 hCV767324 rs687047 hCV32014853 rs11221097 0.9 1 hCV8351640 rs842796 hCV9110432 rs12025826 0.9 0.9273 hCV8375036 rs9960 hCV1166092 rs12406279 0.9 1 hCV8375036 rs9960 hCV1166096 rs12406643 0.9 1 hCV8375036 rs9960 hDV70946874 rs17386162 0.9 1 hCV8375364 rs966583 hCV26441140 rs9325191 0.9 1 hCV8375364 rs966583 hCV2690333 rs11178602 0.9 1 hCV8375364 rs966583 hCV2690348 rs11178594 0.9 1 hCV8375364 rs966583 hCV2690350 rs2132242 0.9 1 hCV8375364 rs966583 hCV2690354 rs11178589 0.9 1 hCV8375364 rs966583 hCV2690362 rs10879249 0.9 1 hCV8375364 rs966583 hCV2690365 rs11178583 0.9 1 hCV8375364 rs966583 hCV2690375 rs1567740 0.9 1 hCV8375364 rs966583 hCV2690377 rs10879245 0.9 1 hCV8375364 rs966583 hCV2690378 rs11178579 0.9 1 hCV8375364 rs966583 hCV2690379 rs10879242 0.9 1 hCV8375364 rs966583 hCV2690380 rs10506623 0.9 1 hCV8375364 rs966583 hCV2690388 rs2132241 0.9 1 hCV8375364 rs966583 hCV31190567 rs7311994 0.9 1 hCV8375364 rs966583 hCV31190598 rs12818936 0.9 1 hCV8375364 rs966583 hCV8871988 rs1495375 0.9 1 hCV8375364 rs966583 hCV8871989 rs1512989 0.9 1 hCV8375364 rs966583 hCV8871990 rs1512988 0.9 1 hCV8375364 rs966583 hCV8873466 rs1051344 0.9 1 hCV8375364 rs966583 hCV8873472 rs1355373 0.9 1 hCV8719512 rs4773 hCV8719513 rs1266483 0.9 0.9781 hCV8719512 rs4773 hCV8719628 rs1266489 0.9 1 hCV8719628 rs1266489 hCV12100073 rs871078 0.9 0.9543 hCV8719628 rs1266489 hCV27008723 rs2677744 0.9 0.955 hCV8719628 rs1266489 hCV2979204 rs734252 0.9 1 hCV8719628 rs1266489 hCV8718176 rs1550636 0.9 0.955 hCV8719628 rs1266489 hCV8719512 rs4773 0.9 1 hCV8719628 rs1266489 hCV8719513 rs1266483 0.9 1 hCV8793528 rs9857 hCV1973774 rs1483301 0.9 1 hCV8873448 rs3844207 hCV2690291 rs2270588 0.9 1 hCV8873448 rs3844207 hCV2690292 rs2270589 0.9 0.9298 hCV8905894 rs974950 hCV16126066 rs2110564 0.9 1 hCV8905894 rs974950 hCV2676440 rs6722640 0.9 1 hCV8905894 rs974950 hCV27872026 rs4851531 0.9 0.9812 hCV8905894 rs974950 hCV349805 rs4851529 0.9 0.9303 hCV8932829 rs1116596 hCV11819780 rs12153185 0.9 0.9232 hCV8932829 rs1116596 hCV11819782 rs12719415 0.9 0.927 hCV8932829 rs1116596 hCV2575318 rs7711358 0.9 1 hCV8932829 rs1116596 hCV2575336 rs2418541 0.9 1 hCV8932829 rs1116596 hCV2575340 rs11242020 0.9 1 hCV8932829 rs1116596 hCV26478747 rs2190598 0.9 0.9239 hCV8932829 rs1116596 hCV26478763 rs2418542 0.9 1 hCV8932829 rs1116596 hCV27996154 rs4836502 0.9 0.927 hCV8932829 rs1116596 hCV2961244 rs2418548 0.9 0.9232 hCV8932829 rs1116596 hCV2961250 rs4836507 0.9 0.927 hCV8932829 rs1116596 hCV2961252 rs10067895 0.9 0.927 hCV8932829 rs1116596 hCV2961253 rs2190600 0.9 0.927 hCV8932829 rs1116596 hCV2961260 rs11242022 0.9 0.9232 hCV8932829 rs1116596 hCV2961261 rs11242021 0.9 0.9255 hCV8932829 rs1116596 hCV2961267 rs1476714 0.9 0.9607 hCV8932829 rs1116596 hCV2961268 rs2108425 0.9 0.927 hCV8932829 rs1116596 hCV2961269 rs2158958 0.9 0.927 hCV8932829 rs1116596 hCV2961270 rs9327555 0.9 0.927 hCV8932829 rs1116596 hCV2961278 rs7446891 0.9 0.927 hCV8932829 rs1116596 hCV2961280 rs10520072 0.9 0.927 hCV8932829 rs1116596 hCV2961282 rs917295 0.9 0.927 hCV8932829 rs1116596 hCV2961284 rs10054055 0.9 0.9616 hCV8932829 rs1116596 hCV2961296 rs10051148 0.9 0.9623 hCV8932829 rs1116596 hCV2961297 rs2158961 0.9 0.9634 hCV8932829 rs1116596 hCV2961306 rs264129 0.9 0.9232 hCV8932829 rs1116596 hCV30621656 rs10478919 0.9 1 hCV8932829 rs1116596 hCV31237567 rs11749272 0.9 1 hCV8932829 rs1116596 hCV346713 rs1990023 0.9 1 hCV8932829 rs1116596 hCV546489 rs264122 0.9 0.9616 hCV9110432 rs12025826 hCV8351640 rs842796 0.9 0.9273 hCV940416 rs498657 hCV3125582 rs2243708 0.9 1 hDV70820190 rs17035071 hDV70820183 rs17035064 0.9 1 hDV70820190 rs17035071 hDV70820188 rs17035069 0.9 1 hDV70936275 rs17310169 hDV70936277 rs17310176 0.9 1 hDV70936277 rs17310176 hDV70936275 rs17310169 0.9 1 hDV70985165 rs17662322 hDV70995198 rs17718867 0.9 1 hDV70995198 rs17718867 hDV70985165 rs17662322 0.9 1 hDV72015086 rs7956274 hCV11686367 rs7955901 0.9 1 hDV72015086 rs7956274 hCV171102 rs7313973 0.9 0.9584 hDV72015086 rs7956274 hCV240133 rs4760895 0.9 0.9649 hDV72015086 rs7956274 hCV240134 rs7138300 0.9 0.9622 hDV72015086 rs7956274 hCV2745800 rs11178531 0.9 0.9261 hDV72015086 rs7956274 hCV2745805 rs7132840 0.9 0.9261 hDV72015086 rs7956274 hCV2745815 rs1512991 0.9 1 hDV72015086 rs7956274 hCV2745822 rs1913201 0.9 0.9622 hDV72015086 rs7956274 hCV2745828 rs10879240 0.9 0.9285 hDV72015086 rs7956274 hCV27952502 rs4760894 0.9 0.9649 hDV72015086 rs7956274 hCV27952503 rs4760785 0.9 0.9649 hDV72015086 rs7956274 hCV29120310 rs7298255 0.9 1 hDV72015086 rs7956274 hCV31190748 rs7959965 0.9 1 hDV72015086 rs7956274 hCV31190777 rs10784891 0.9 1 hDV76981734 rs4251569 hCV27943699 rs4238087 0.9 1

TABLE 4 allele A1 allele Meta-analysis CARE (non- A2 OR OR Placebo OR OR Marker ref) (ref) OR L95 U95 P value Prava Count Count OR L95 U95 P value Source rs2157673 G A 1.50 1.26 1.78 5.54E−06 50/156/151 28/189/227 1.47 1.18 1.82 5.43E−04 Caseonly rs12155847 G A 1.66 1.32 2.09 1.80E−05 47/174/136 45/173/226 1.69 1.27 2.24 3.58E−04 Caseonly rs9292827 A G 0.34 0.20 0.56 3.46E−05 1/14/342 1/47/395 0.37 0.20 0.67 1.08E−03 Caseonly rs2695026 A G 0.67 0.55 0.81 3.85E−05 18/116/221 43/164/236 0.70 0.55 0.88 2.23E−03 Caseonly rs205279 A G 1.81 1.36 2.41 4.59E−05 5/78/274 2/61/381 1.94 1.36 2.76 2.54E−04 Caseonly rs17706237 G A 1.69 1.31 2.19 5.77E−05 13/111/176 13/94/275 1.80 1.31 2.49 3.42E−04 CaseOnly rs10120126 G A 0.51 0.37 0.71 5.98E−05 4/43/253 11/87/284 0.53 0.36 0.78 1.55E−03 CaseOnly rs1948 A G 1.66 1.29 2.13 6.47E−05 40/134/126 38/146/198 1.52 1.12 2.07 7.49E−03 CaseOnly rs10088505 A G 1.61 1.27 2.03 6.58E−05 38/180/139 51/177/215 1.52 1.14 2.03 4.28E−03 Caseonly rs354342 A G 0.67 0.55 0.82 6.82E−05 17/115/225 37/171/236 0.70 0.55 0.89 3.07E−03 Caseonly rs1035618 A C 1.42 1.19 1.68 6.96E−05 45/169/140 39/181/219 1.38 1.12 1.71 2.98E−03 Caseonly rs238272 A G 1.45 1.21 1.74 7.57E−05 35/139/126 28/149/205 1.44 1.14 1.82 2.44E−03 CaseOnly rs10849442 A G 0.57 0.43 0.75 8.56E−05 57/207/93 112/220/112 0.56 0.39 0.80 1.36E−03 Caseonly rs2376764 A G 0.56 0.41 0.74 8.56E−05 55/185/117 103/220/121 0.61 0.42 0.88 8.65E−03 Caseonly rs2273816 A G 1.61 1.27 2.05 8.70E−05 9/87/204 5/81/296 1.56 1.15 2.12 4.66E−03 CaseOnly rs2941528 A G 0.67 0.54 0.82 1.79E−04 13/111/176 29/162/191 0.72 0.56 0.93 1.31E−02 CaseOnly rs1615197 G A 1.80 1.25 2.60 1.71E−03 56/146/98 61/158/163 1.54 1.12 2.11 7.76E−03 CaseOnly rs1349282 A G 0.55 0.44 0.69 3.97E−07 254/731/509 290/709/472 0.55 0.41 0.74 1.05E−04 cohort rs4986146 A G 0.63 0.53 0.76 4.36E−07 109/579/807 89/562/818 0.62 0.49 0.77 2.63E−05 cohort rs3213616 A G 0.62 0.51 0.76 2.68E−06 74/479/933 75/465/920 0.62 0.49 0.80 1.60E−04 cohort rs2008165 G A 0.59 0.47 0.73 2.77E−06 650/115/728 676/99/695 0.57 0.43 0.76 1.06E−04 cohort rs10500736 G A 0.57 0.45 0.72 2.82E−06 254/1214/1417 130/603/700 0.61 0.45 0.83 1.62E−03 cohort rs7705993 G A 1.48 1.24 1.76 9.34E−06 370/724/401 333/755/382 1.50 1.21 1.85 1.98E−04 cohort rs12556591 G A 0.59 0.47 0.75 1.04E−05 625/114/755 665/95/710 0.57 0.43 0.75 7.93E−05 cohort rs2534752 G A 1.65 1.32 2.07 1.17E−05 63/485/947 51/467/951 1.60 1.19 2.15 1.67E−03 cohort rs4830819 G A 0.60 0.48 0.75 1.36E−05 641/113/740 673/97/699 0.57 0.43 0.76 8.61E−05 cohort rs10189905 C A 0.52 0.39 0.70 1.52E−05 12/256/1227 13/281/1177 0.50 0.34 0.73 3.92E−04 cohort rs316720 G A 0.71 0.61 0.83 2.28E−05 223/758/514 265/690/516 0.67 0.55 0.82 1.19E−04 cohort rs3998860 A G 0.61 0.49 0.77 2.29E−05 129/851/1903 75/416/941 0.58 0.44 0.76 7.97E−05 cohort rs3732788 G A 0.51 0.38 0.70 2.57E−05 16/212/1267 14/275/1180 0.56 0.38 0.81 2.46E−03 cohort rs669684 G A 0.72 0.62 0.84 2.85E−05 260/758/476 309/690/472 0.69 0.56 0.84 2.75E−04 cohort rs2418412 G A 1.94 1.42 2.65 3.05E−05 270/722/502 272/703/494 2.20 1.48 3.25 8.63E−05 cohort rs13279522 G A 0.62 0.50 0.78 3.67E−05 51/391/1053 51/438/981 0.62 0.47 0.83 1.13E−03 cohort rs7193741 A C 2.04 1.45 2.86 3.91E−05 233/716/546 212/700/559 2.16 1.39 3.36 6.33E−04 cohort rs151806 G A 0.63 0.50 0.78 4.01E−05 78/545/871 75/578/816 0.60 0.45 0.80 4.38E−04 cohort rs9446187 A G 1.96 1.42 2.72 4.36E−05 19/268/1208 16/238/1217 1.92 1.28 2.87 1.53E−03 cohort rs2793086 C A 0.65 0.53 0.80 4.71E−05 53/498/944 55/441/975 0.61 0.47 0.80 2.19E−04 cohort rs17076974 A G 1.40 1.19 1.65 5.58E−05 361/727/405 323/756/392 1.46 1.18 1.81 4.91E−04 cohort rs4924215 A G 1.65 1.29 2.11 5.58E−05 215/1214/1535 106/594/769 1.77 1.30 2.39 2.41E−04 cohort rs1884897 A G 2.07 1.45 2.95 5.65E−05 214/702/578 192/687/591 2.24 1.45 3.46 2.93E−04 cohort rs610118 G A 0.49 0.34 0.69 5.81E−05 24/201/1269 15/201/1253 0.43 0.28 0.66 1.35E−04 cohort rs7179134 A G 3.52 1.90 6.52 6.11E−05 67/464/964 64/466/941 3.54 1.54 8.15 2.91E−03 cohort rs4993917 A C 0.60 0.47 0.77 6.48E−05 322/746/427 320/722/429 0.57 0.42 0.77 3.33E−04 cohort rs7671659 A G 1.60 1.27 2.02 6.68E−05 59/427/1009 58/430/983 1.72 1.28 2.32 3.19E−04 cohort rs10889215 A G 1.63 1.28 2.06 6.72E−05 35/297/1162 30/280/1158 1.50 1.13 1.99 5.01E−03 cohort rs9487284 A G 0.64 0.52 0.80 6.85E−05 212/634/648 163/669/637 0.61 0.46 0.80 4.52E−04 cohort rs7742508 A G 2.08 1.45 2.99 6.86E−05 13/205/1277 6/192/1272 2.19 1.37 3.49 9.74E−04 cohort rs2492367 A G 0.61 0.47 0.78 7.23E−05 16/325/1153 17/307/1146 0.56 0.40 0.77 4.19E−04 cohort rs10429616 G A 1.85 1.36 2.50 7.30E−05 276/736/481 282/699/488 2.07 1.41 3.04 2.21E−04 cohort rs2069542 A G 1.62 1.28 2.05 7.35E−05 103/802/2061 44/398/1029 1.67 1.26 2.22 3.45E−04 cohort rs10155047 A G 0.55 0.41 0.74 7.66E−05 18/215/1262 15/273/1183 0.59 0.40 0.85 5.11E−03 cohort rs4626316 A G 0.35 0.21 0.59 8.00E−05 10/94/1388 13/98/1358 0.34 0.18 0.64 7.09E−04 cohort rs17138705 A G 0.59 0.45 0.77 8.17E−05 25/336/1134 36/343/1092 0.54 0.39 0.74 1.78E−04 cohort rs10494924 C A 0.64 0.51 0.80 9.70E−05 143/606/744 141/639/690 0.61 0.46 0.81 6.69E−04 cohort rs33910446 A G 2.24 1.49 3.36 1.02E−04 128/573/791 107/558/804 2.24 1.34 3.75 1.99E−03 cohort rs1051344 G C 0.64 0.51 0.80 1.07E−04 262/694/537 253/734/484 0.64 0.48 0.86 2.62E−03 cohort rs10444402 G A 0.69 0.57 0.83 1.16E−04 74/522/899 102/500/868 0.71 0.57 0.89 3.33E−03 cohort rs7612715 A G 0.50 0.35 0.71 1.21E−04 18/161/1316 8/160/1303 0.47 0.30 0.73 9.43E−04 cohort rs4243071 G A 0.43 0.28 0.66 1.22E−04 274/1165/1527 143/535/793 0.44 0.26 0.76 2.80E−03 cohort rs624460 A G 0.73 0.63 0.86 1.24E−04 208/651/635 216/667/588 0.73 0.60 0.90 2.54E−03 cohort rs4866354 G A 0.35 0.20 0.59 1.25E−04 0/102/1392 0/107/1363 0.36 0.19 0.67 1.19E−03 cohort rs945020 A G 0.65 0.52 0.81 1.33E−04 390/1333/1162 203/669/561 0.61 0.45 0.81 6.95E−04 cohort rs9859901 A C 0.52 0.38 0.73 1.37E−04 17/214/1264 16/270/1185 0.59 0.41 0.86 5.91E−03 cohort rs7629632 G A 1.62 1.26 2.07 1.38E−04 171/687/637 169/638/664 1.56 1.15 2.12 4.23E−03 cohort rs17740227 G A 1.70 1.29 2.23 1.45E−04 21/306/1166 21/295/1155 1.80 1.28 2.53 6.94E−04 cohort rs2263920 G A 0.46 0.31 0.69 1.45E−04 197/704/593 207/668/596 0.49 0.30 0.79 3.40E−03 cohort rs1538185 A G 1.60 1.26 2.05 1.51E−04 69/499/927 52/432/987 1.75 1.28 2.41 5.47E−04 cohort rs2843171 A G 0.64 0.51 0.81 1.54E−04 103/585/806 124/584/761 0.67 0.50 0.88 4.44E−03 cohort rs4726711 G A 0.71 0.59 0.85 1.61E−04 217/674/604 197/712/562 0.75 0.60 0.94 1.19E−02 cohort rs2263901 G A 1.48 1.21 1.81 1.63E−04 84/533/876 61/508/899 1.43 1.11 1.84 5.41E−03 cohort rs5021480 A C 1.78 1.32 2.40 1.67E−04 544/1410/929 254/697/481 1.72 1.18 2.52 4.85E−03 cohort rs1877986 A G 0.62 0.48 0.80 1.73E−04 569/1391/924 283/699/451 0.57 0.41 0.78 5.70E−04 cohort rs11610993 G A 0.43 0.28 0.67 1.76E−04 6/131/1358 3/140/1328 0.41 0.25 0.69 7.19E−04 cohort rs1864924 G A 1.40 1.17 1.67 1.78E−04 210/620/664 192/652/627 1.42 1.15 1.77 1.40E−03 cohort rs17347854 G A 0.61 0.48 0.79 1.79E−04 40/356/1099 38/404/1028 0.61 0.44 0.84 2.13E−03 cohort rs13137776 G A 0.70 0.58 0.84 1.83E−04 148/636/711 158/661/652 0.74 0.59 0.94 1.18E−02 cohort rs3759607 G A 1.96 1.38 2.78 1.90E−04 4/209/1281 4/165/1302 2.10 1.35 3.28 1.06E−03 cohort rs9896077 G A 0.66 0.53 0.82 2.07E−04 209/677/608 196/699/576 0.63 0.47 0.83 1.35E−03 cohort rs10935907 G A 1.59 1.24 2.03 2.12E−04 112/544/838 80/535/856 1.65 1.21 2.23 1.37E−03 cohort rs7625204 A G 1.45 1.19 1.77 2.24E−04 119/980/1866 52/488/931 1.51 1.16 1.96 2.11E−03 cohort rs13431868 A G 1.59 1.24 2.03 2.24E−04 82/554/857 71/538/860 1.70 1.25 2.31 7.44E−04 cohort rs2231496 G A 0.72 0.60 0.86 2.27E−04 133/622/740 140/618/713 0.74 0.60 0.92 6.39E−03 cohort rs1705244 G A 0.60 0.46 0.79 2.28E−04 650/1518/798 307/782/382 0.65 0.46 0.91 1.20E−02 cohort rs2274473 G A 0.55 0.40 0.75 2.28E−04 27/264/1202 26/297/1147 0.58 0.39 0.85 5.84E−03 cohort rs5750116 G A 1.55 1.23 1.97 2.28E−04 139/685/671 129/641/701 1.63 1.20 2.22 1.69E−03 cohort rs912366 G A 1.66 1.27 2.18 2.29E−04 31/393/1071 21/357/1093 1.60 1.14 2.24 6.82E−03 cohort rs1544214 A G 1.38 1.16 1.64 2.36E−04 461/1344/1080 212/678/543 1.40 1.13 1.74 2.38E−03 cohort rs1861326 A G 0.64 0.51 0.82 2.44E−04 226/692/577 238/710/521 0.63 0.47 0.85 1.90E−03 cohort rs2265346 C A 0.54 0.39 0.75 2.59E−04 20/249/1226 20/287/1164 0.60 0.40 0.90 1.27E−02 cohort rs7521242 A G 0.72 0.61 0.86 2.77E−04 630/1424/829 326/707/398 0.71 0.57 0.88 2.19E−03 cohort rs10305439 A C 0.62 0.48 0.80 2.78E−04 245/729/521 269/745/457 0.62 0.45 0.85 2.76E−03 cohort rs1167245 A G 0.62 0.47 0.80 2.79E−04 350/728/417 369/693/408 0.68 0.50 0.92 1.29E−02 cohort rs2495295 G A 0.66 0.52 0.82 2.89E−04 136/608/751 143/629/697 0.65 0.49 0.87 3.00E−03 cohort rs312929 G A 0.75 0.64 0.87 2.96E−04 202/704/589 224/698/549 0.72 0.59 0.88 1.71E−03 cohort rs969356 G A 0.63 0.49 0.81 3.10E−04 207/675/612 192/716/561 0.69 0.51 0.94 2.00E−02 cohort rs5017584 A G 1.74 1.29 2.36 3.25E−04 279/720/496 245/694/531 1.61 1.10 2.37 1.46E−02 cohort rs6491586 G A 1.65 1.26 2.18 3.26E−04 28/377/1090 21/336/1114 1.59 1.13 2.24 8.26E−03 cohort rs842796 A G 1.59 1.23 2.05 3.30E−04 248/697/550 219/684/568 1.72 1.26 2.37 7.49E−04 cohort rs4869033 G A 0.36 0.21 0.63 3.53E−04 244/1142/1580 135/569/767 0.31 0.16 0.63 1.20E−03 cohort rs10973013 A G 0.55 0.40 0.77 3.59E−04 21/256/1218 21/297/1153 0.59 0.40 0.88 9.32E−03 cohort rs886469 G A 0.64 0.50 0.82 3.96E−04 199/671/625 184/708/579 0.70 0.51 0.95 2.12E−02 cohort rs11076320 C A 0.65 0.52 0.83 4.01E−04 233/691/568 249/708/512 0.64 0.48 0.86 2.64E−03 cohort rs2145540 A G 0.56 0.40 0.77 4.02E−04 18/247/1230 14/282/1175 0.51 0.35 0.75 5.69E−04 cohort rs6505669 G A 1.58 1.22 2.03 4.18E−04 59/496/940 52/463/956 1.70 1.24 2.34 9.67E−04 cohort rs9375683 G A 1.49 1.19 1.87 4.39E−04 86/527/882 67/465/939 1.63 1.22 2.18 8.91E−04 cohort rs10814422 G A 0.57 0.42 0.78 4.75E−04 28/284/1182 30/309/1130 0.64 0.44 0.92 1.72E−02 cohort rs72746987 A G 0.40 0.24 0.67 4.89E−04 3/96/1396 4/139/1328 0.43 0.24 0.80 7.44E−03 cohort rs13318232 G A 0.52 0.36 0.75 5.01E−04 17/212/1266 18/264/1189 0.60 0.40 0.90 1.34E−02 cohort rs2268650 A G 0.66 0.53 0.84 5.28E−04 190/697/608 215/695/560 0.64 0.48 0.85 2.27E−03 cohort rs4682522 C A 0.55 0.39 0.77 5.52E−04 29/417/2519 18/224/1229 0.59 0.39 0.90 1.55E−02 cohort rs3798544 A G 1.57 1.21 2.03 5.87E−04 32/400/1062 42/342/1087 1.47 1.08 2.02 1.55E−02 cohort rs6080603 A C 0.62 0.47 0.81 5.91E−04 93/835/2038 46/443/982 0.59 0.42 0.83 2.06E−03 cohort rs10517923 A G 1.61 1.23 2.12 5.93E−04 352/720/422 311/730/429 1.62 1.16 2.26 4.84E−03 cohort rs2104506 A C 0.71 0.59 0.87 5.99E−04 114/593/788 106/608/757 0.75 0.59 0.96 2.07E−02 cohort rs2023650 A G 0.71 0.59 0.87 6.11E−04 81/533/878 98/523/846 0.76 0.60 0.96 2.20E−02 cohort rs8051893 A G 0.67 0.53 0.84 6.22E−04 424/1374/1167 216/699/555 0.69 0.52 0.92 1.05E−02 cohort rs8109631 A G 1.53 1.20 1.96 6.35E−04 119/625/749 109/573/789 1.53 1.13 2.07 6.36E−03 cohort rs331555 A C 0.74 0.62 0.88 6.42E−04 245/1285/1432 141/632/695 0.72 0.58 0.89 2.91E−03 cohort rs1343563 C A 0.60 0.45 0.81 6.82E−04 22/273/1199 23/301/1145 0.61 0.43 0.88 6.99E−03 cohort rs11082492 A C 1.55 1.20 2.00 6.99E−04 31/369/1095 27/347/1095 1.46 1.07 1.99 1.65E−02 cohort rs17546598 A G 1.71 1.25 2.33 7.18E−04 22/465/2471 10/210/1247 1.57 1.08 2.28 1.91E−02 cohort rs1382787 G A 1.35 1.13 1.61 7.52E−04 558/1447/961 288/679/504 1.37 1.10 1.69 4.46E−03 cohort rs6075209 A G 0.64 0.50 0.83 7.71E−04 499/1425/1042 275/687/509 0.63 0.46 0.86 3.35E−03 cohort rs11925875 A G 0.66 0.52 0.84 7.79E−04 271/707/516 304/700/467 0.72 0.53 0.97 3.13E−02 cohort rs13314266 G A 0.51 0.35 0.76 8.20E−04 9/185/1301 11/228/1231 0.60 0.40 0.91 1.49E−02 cohort rs3000490 G A 1.38 1.14 1.66 8.36E−04 248/1186/1532 118/575/778 1.45 1.15 1.83 1.71E−03 cohort rs4289236 A G 1.41 1.15 1.72 8.44E−04 68/450/975 74/406/990 1.37 1.08 1.75 1.04E−02 cohort rs2060411 A G 1.39 1.15 1.69 8.75E−04 228/1159/1579 97/568/806 1.37 1.07 1.74 1.10E−02 cohort rs4643388 G A 1.34 1.12 1.59 9.82E−04 166/639/690 123/628/720 1.32 1.07 1.62 1.06E−02 cohort rs9436636 A G 1.35 1.13 1.61 1.02E−03 446/1361/1079 200/680/554 1.34 1.08 1.67 8.75E−03 cohort rs7327364 A G 0.68 0.53 0.85 1.05E−03 249/686/560 218/746/507 0.69 0.52 0.93 1.30E−02 cohort rs2626130 G A 1.32 1.11 1.55 1.17E−03 471/1436/978 220/698/515 1.29 1.05 1.58 1.61E−02 cohort rs4611134 A G 1.55 1.19 2.01 1.20E−03 388/723/377 322/721/419 1.54 1.11 2.14 1.05E−02 cohort rs17716275 A G 2.03 1.32 3.13 1.32E−03 7/286/2593 3/128/1303 1.91 1.11 3.29 2.01E−02 cohort rs7094941 G A 0.74 0.62 0.89 1.36E−03 160/670/665 188/640/643 0.78 0.63 0.98 3.41E−02 cohort rs1076733 A G 0.67 0.53 0.86 1.37E−03 258/765/471 294/740/433 0.70 0.52 0.95 2.12E−02 cohort rs2290193 C A 0.47 0.30 0.75 1.38E−03 253/1183/1529 142/574/755 0.53 0.31 0.92 2.33E−02 cohort rs10103297 A G 2.03 1.31 3.13 1.46E−03 9/146/1339 7/114/1348 1.84 1.12 3.04 1.64E−02 cohort rs12657484 G A 1.49 1.16 1.90 1.49E−03 133/632/727 107/581/782 1.36 1.01 1.85 4.48E−02 cohort rs7910196 G A 1.47 1.16 1.87 1.59E−03 42/391/1062 26/338/1106 1.36 1.01 1.82 4.11E−02 cohort rs7767024 A G 1.42 1.14 1.77 1.78E−03 37/388/1070 45/361/1065 1.32 1.01 1.72 4.01E−02 cohort rs1474396 A C 1.46 1.15 1.86 1.87E−03 277/717/501 272/684/515 1.35 1.00 1.81 4.91E−02 cohort rs1182878 A G 0.78 0.66 0.91 1.97E−03 314/718/462 319/711/440 0.79 0.65 0.96 1.81E−02 cohort rs2483641 A G 0.59 0.43 0.83 2.06E−03 14/230/1250 16/279/1174 0.65 0.43 0.97 3.34E−02 cohort rs453625 A G 0.62 0.46 0.85 2.44E−03 18/236/1240 19/288/1164 0.66 0.46 0.95 2.70E−02 cohort rs7497613 A G 0.55 0.37 0.81 2.66E−03 649/1470/765 331/720/382 0.65 0.46 0.91 1.17E−02 cohort rs2129571 A G 0.53 0.34 0.80 2.81E−03 17/215/1263 14/269/1186 0.62 0.43 0.90 1.22E−02 cohort rs16861467 G A 0.49 0.31 0.78 2.93E−03 15/205/1275 12/258/1201 0.60 0.41 0.87 7.69E−03 cohort rs10088524 G A 1.57 1.17 2.11 3.00E−03 14/255/1226 10/212/1249 1.46 1.00 2.11 4.73E−02 cohort rs10875941 G A 0.63 0.45 0.89 9.49E−03 118/582/795 141/581/748 0.73 0.54 0.99 4.41E−02 cohort rs7616936 C A 1.77 1.15 2.72 9.52E−03 26/335/1133 24/279/1166 1.47 1.01 2.14 4.46E−02 cohort rs6911817 A G 2.85 1.25 6.50 1.28E−02 2/80/1413 2/58/1411 2.15 1.08 4.25 2.83E−02 cohort rs9658127 A G 2.79 1.15 6.77 2.36E−02 2/83/1409 2/60/1409 2.03 1.05 3.93 3.58E−02 cohort WOSCOPS OR OR End- Marker Prava Count Placebo Count OR L95 U95 P value Source Model point rs2157673 24/85/75 19/93/135 1.56 1.16 2.09 2.99E−03 Caseonly add CVD rs12155847 18/90/76 19/99/129 1.61 1.09 2.37 1.71E−02 Caseonly dom CVD rs9292827 2/3/179 1/22/224 0.27 0.10 0.73 9.50E−03 Caseonly dom CVD rs2695026 5/52/124 16/92/137 0.61 0.43 0.86 4.67E−03 Caseonly add CVD rs205279 0/43/141 0/39/208 1.60 0.99 2.60 5.76E−02 Caseonly add CVD rs17706237 7/61/91 9/65/150 1.52 1.00 2.31 5.28E−02 CaseOnly dom CHD rs10120126 3/16/139 5/44/175 0.48 0.27 0.86 1.30E−02 CaseOnly dom CHD rs1948 19/88/52 27/88/109 1.96 1.29 3.00 1.83E−03 CaseOnly dom CHD rs10088505 24/87/70 23/93/127 1.78 1.20 2.63 4.27E−03 Caseonly dom CVD rs354342 5/51/128 15/90/142 0.62 0.44 0.87 6.35E−03 Caseonly add CVD rs1035618 31/86/66 23/111/111 1.48 1.11 1.98 7.61E−03 Caseonly add CVD rs238272 32/64/63 22/94/108 1.46 1.09 1.96 1.07E−02 CaseOnly add CHD rs10849442 37/100/46 73/100/74 0.59 0.37 0.93 2.26E−02 Caseonly rec CVD rs2376764 30/99/55 71/117/58 0.48 0.29 0.77 2.46E−03 Caseonly rec CVD rs2273816 10/46/103 5/49/170 1.69 1.16 2.47 6.17E−03 CaseOnly add CHD rs2941528 12/50/96 21/112/91 0.58 0.41 0.81 1.38E−03 CaseOnly add CHD rs1615197 38/81/40 28/98/98 2.25 1.44 3.52 3.75E−04 CaseOnly dom CHD rs1349282 459/1274/924 469/1271/918 0.55 0.38 0.79 1.10E−03 cohort dom CVD rs4986146 175/1031/1436 181/1039/1427 0.66 0.50 0.88 4.63E−03 cohort add CVD rs3213616 77/807/1767 79/852/1727 0.62 0.45 0.87 5.26E−03 cohort add CVD rs2008165 1301/6/1343 1261/4/1393 0.62 0.43 0.89 9.37E−03 cohort add CHD rs10500736 230/1135/1290 256/1109/1296 0.52 0.36 0.75 4.18E−04 cohort dom CHD rs7705993 44/77/38 38/117/69 1.44 1.07 1.94 1.57E−02 CaseOnly add CHD rs12556591 66/0/93 115/0/109 0.66 0.44 1.00 4.88E−02 CaseOnly add CHD rs2534752 112/890/1649 129/915/1613 1.74 1.22 2.47 2.10E−03 cohort dom CVD rs4830819 66/0/93 115/0/109 0.66 0.44 1.00 4.88E−02 CaseOnly add CHD rs10189905 15/496/2143 30/434/2195 0.56 0.36 0.88 1.21E−02 cohort add CHD rs316720 531/1320/796 540/1301/814 0.78 0.61 1.00 4.57E−02 cohort add CVD rs3998860 3/44/112 6/80/138 0.70 0.47 1.05 8.17E−02 CaseOnly add CHD rs3732788 0/21/138 3/53/168 0.44 0.26 0.75 2.64E−03 CaseOnly add CHD rs669684 633/1333/689 626/1318/715 0.77 0.60 0.97 3.00E−02 cohort add CVD rs2418412 450/1353/847 454/1264/942 1.58 0.96 2.62 7.27E−02 cohort rec CHD rs13279522 73/693/1889 57/696/1911 0.63 0.44 0.90 1.12E−02 cohort add CHD rs7193741 368/1263/1022 372/1225/1064 1.87 1.10 3.18 2.01E−02 cohort rec CHD rs151806 142/909/1597 124/918/1611 0.67 0.47 0.96 2.92E−02 cohort dom CVD rs9446187 11/338/2307 8/305/2347 2.05 1.19 3.53 9.61E−03 cohort dom CHD rs2793086 3/56/125 11/85/151 0.72 0.50 1.02 6.63E−02 Caseonly add CVD rs17076974 594/1320/729 578/1344/726 1.32 1.02 1.71 3.48E−02 cohort add CHD rs4924215 12/67/80 19/71/134 1.46 0.97 2.21 6.97E−02 CaseOnly dom CHD rs1884897 26/73/60 22/116/86 1.78 0.97 3.29 6.31E−02 CaseOnly rec CHD rs610118 1/18/165 1/37/209 0.62 0.34 1.12 1.10E−01 Caseonly dom CVD rs7179134 102/858/1693 109/872/1674 3.50 1.40 8.72 7.28E−03 cohort rec CVD rs4993917 37/89/58 52/136/59 0.67 0.43 1.03 6.44E−02 Caseonly dom CVD rs7671659 81/726/1845 59/733/1863 1.43 0.99 2.07 5.96E−02 cohort dom CVD rs10889215 30/407/2217 21/395/2247 1.95 1.27 3.00 2.22E−03 cohort add CVD rs9487284 293/1216/1142 335/1259/1063 0.70 0.50 0.99 4.62E−02 cohort dom CVD rs7742508 0/296/2357 0/257/2401 1.93 1.09 3.43 2.42E−02 cohort dom CHD rs2492367 44/578/2033 42/585/2033 0.68 0.46 1.00 4.80E−02 cohort add CVD rs10429616 481/1361/815 479/1282/901 1.54 0.94 2.51 8.52E−02 cohort rec CHD rs2069542 1/49/109 1/51/172 1.49 0.96 2.32 7.85E−02 CaseOnly add CHD rs10155047 18/437/2201 30/467/2163 0.50 0.31 0.80 4.45E−03 cohort add CHD rs4626316 3/118/2537 3/111/2547 0.38 0.15 0.97 4.23E−02 cohort dom CVD rs17138705 0/32/127 6/51/167 0.70 0.44 1.11 1.28E−01 CaseOnly add CHD rs10494924 19/65/100 22/115/110 0.68 0.46 1.00 5.11E−02 Caseonly dom CVD rs33910446 24/74/85 16/113/118 2.23 1.14 4.34 1.87E−02 Caseonly rec CVD rs1051344 431/1243/981 416/1234/1008 0.64 0.45 0.92 1.47E−02 cohort dom CVD rs10444402 7/62/115 18/103/126 0.65 0.47 0.91 1.12E−02 Caseonly add CVD rs7612715 6/242/2408 12/257/2393 0.55 0.31 0.99 4.49E−02 cohort add CVD rs4243071 11/76/97 32/91/124 0.41 0.20 0.85 1.56E−02 Caseonly rec CVD rs624460 350/1250/1054 389/1245/1022 0.74 0.57 0.95 1.78E−02 cohort add CVD rs4866354 0/4/180 0/16/231 0.31 0.10 0.94 3.92E−02 Caseonly dom CVD rs945020 385/1221/1049 395/1260/1003 0.72 0.51 1.01 5.77E−02 cohort dom CVD rs9859901 0/20/139 3/53/168 0.41 0.24 0.72 1.59E−03 CaseOnly add CHD rs7629632 15/83/60 22/87/115 1.72 1.13 2.60 1.10E−02 CaseOnly dom CHD rs17740227 0/48/136 2/45/200 1.53 0.96 2.42 7.13E−02 Caseonly dom CVD rs2263920 11/71/77 36/100/88 0.41 0.20 0.84 1.42E−02 CaseOnly rec CHD rs1538185 101/868/1686 109/864/1680 1.41 0.96 2.07 7.60E−02 cohort dom CHD rs2843171 15/58/111 20/109/118 0.61 0.41 0.89 1.16E−02 Caseonly dom CVD rs4726711 15/62/82 33/109/82 0.62 0.45 0.85 2.88E−03 CaseOnly add CHD rs2263901 11/62/86 10/62/152 1.57 1.12 2.21 9.90E−03 CaseOnly add CHD rs5021480 45/77/62 37/106/104 1.87 1.15 3.04 1.21E−02 Caseonly rec CVD rs1877986 494/1321/831 518/1314/820 0.71 0.48 1.05 8.37E−02 cohort dom CHD rs11610993 0/8/176 0/20/227 0.49 0.21 1.14 9.82E−02 Caseonly dom CVD rs1864924 28/68/63 19/106/99 1.36 1.00 1.84 4.79E−02 CaseOnly add CHD rs17347854 3/41/140 13/70/164 0.62 0.41 0.96 3.17E−02 Caseonly dom CVD rs13137776 11/47/101 27/86/111 0.62 0.45 0.86 3.72E−03 CaseOnly add CHD rs3759607 0/29/130 2/24/198 1.73 0.97 3.09 6.18E−02 CaseOnly dom CHD rs9896077 353/1151/1146 406/1253/996 0.71 0.50 1.00 5.20E−02 cohort dom CVD rs10935907 5/74/80 17/72/135 1.49 0.99 2.25 5.72E−02 CaseOnly dom CHD rs7625204 131/897/1628 118/925/1616 1.38 1.02 1.87 3.67E−02 cohort add CHD rs13431868 8/68/83 10/77/137 1.42 0.94 2.14 9.94E−02 CaseOnly dom CHD rs2231496 8/73/103 26/107/114 0.67 0.49 0.91 1.13E−02 Caseonly add CVD rs1705244 37/65/57 52/123/49 0.52 0.33 0.82 5.01E−03 CaseOnly dom CHD rs2274473 2/17/140 3/46/175 0.48 0.27 0.85 1.21E−02 CaseOnly dom CHD rs5750116 296/1113/1245 232/1174/1254 1.45 1.01 2.09 4.63E−02 cohort dom CHD rs912366 6/50/103 7/45/172 1.79 1.14 2.81 1.13E−02 CaseOnly dom CHD rs1544214 42/66/51 37/102/85 1.35 1.02 1.78 3.72E−02 CaseOnly add CHD rs1861326 28/84/72 32/141/74 0.67 0.45 1.00 4.96E−02 Caseonly dom CVD rs2265346 2/15/141 3/46/173 0.42 0.23 0.76 4.46E−03 CaseOnly dom CHD rs7521242 31/80/48 59/114/51 0.74 0.55 1.00 4.85E−02 CaseOnly add CHD rs10305439 30/71/58 37/125/60 0.63 0.40 0.98 3.91E−02 CaseOnly dom CHD rs1167245 45/78/61 63/134/50 0.51 0.33 0.79 2.73E−03 Caseonly dom CVD rs2495295 19/63/102 22/114/111 0.66 0.45 0.98 3.73E−02 Caseonly dom CVD rs312929 350/1243/1054 406/1240/1014 0.79 0.61 1.01 6.04E−02 cohort add CVD rs969356 15/62/82 31/110/83 0.54 0.36 0.82 3.60E−03 CaseOnly dom CHD rs5017584 45/76/63 35/108/104 1.98 1.21 3.24 6.65E−03 Caseonly rec CVD rs6491586 6/48/105 6/44/174 1.78 1.13 2.80 1.37E−02 CaseOnly dom CHD rs842796 22/80/57 39/88/97 1.38 0.91 2.10 1.35E−01 CaseOnly dom CHD rs4869033 7/81/96 18/106/123 0.47 0.19 1.15 9.76E−02 Caseonly rec CVD rs10973013 2/17/140 3/46/174 0.48 0.27 0.85 1.16E−02 CaseOnly dom CHD rs886469 15/62/82 29/111/84 0.55 0.36 0.83 4.53E−03 CaseOnly dom CHD rs11076320 28/85/71 31/141/73 0.68 0.45 1.02 6.00E−02 Caseonly dom CVD rs2145540 1/18/165 2/32/213 0.70 0.38 1.27 2.37E−01 Caseonly dom CVD rs6505669 10/59/90 9/71/144 1.37 0.90 2.09 1.36E−01 CaseOnly dom CHD rs9375683 128/942/1584 132/928/1601 1.31 0.92 1.86 1.36E−01 cohort dom CVD rs10814422 2/18/139 3/50/170 0.46 0.26 0.80 6.31E−03 CaseOnly dom CHD rs72746987 2/4/178 1/21/225 0.34 0.14 0.86 2.29E−02 Caseonly dom CVD rs13318232 0/20/139 3/54/167 0.40 0.23 0.71 1.55E−03 CaseOnly dom CHD rs2268650 29/83/72 31/138/78 0.71 0.47 1.06 9.15E−02 Caseonly dom CVD rs4682522 0/21/138 1/51/172 0.49 0.28 0.85 1.17E−02 CaseOnly dom CHD rs3798544 1/55/128 2/46/199 1.78 1.14 2.79 1.12E−02 Caseonly dom CVD rs6080603 4/32/123 7/61/156 0.68 0.43 1.09 1.11E−01 CaseOnly dom CHD rs10517923 47/86/49 44/131/71 1.60 1.00 2.55 4.93E−02 Caseonly rec CVD rs2104506 15/47/97 23/104/97 0.65 0.47 0.90 8.45E−03 CaseOnly add CHD rs2023650 5/53/126 16/91/139 0.62 0.44 0.87 5.84E−03 Caseonly add CVD rs8051893 20/81/83 34/128/85 0.63 0.43 0.93 2.13E−02 Caseonly dom CVD rs8109631 17/73/69 19/85/120 1.54 1.02 2.32 4.00E−02 CaseOnly dom CHD rs331555 12/83/89 31/108/108 0.77 0.57 1.04 8.69E−02 Caseonly add CVD rs1343563 1/20/138 3/46/175 0.58 0.34 0.97 3.81E−02 CaseOnly add CHD rs11082492 4/42/113 1/42/181 1.76 1.13 2.74 1.28E−02 CaseOnly add CHD rs17546598 1/34/149 0/25/222 2.07 1.19 3.61 1.02E−02 Caseonly dom CVD rs1382787 36/85/38 40/113/71 1.32 0.98 1.78 6.95E−02 CaseOnly add CHD rs6075209 26/75/58 40/123/61 0.68 0.44 1.07 9.33E−02 CaseOnly dom CHD rs11925875 26/83/75 48/129/70 0.57 0.38 0.85 6.05E−03 Caseonly dom CVD rs13314266 0/18/141 3/49/172 0.40 0.23 0.71 1.61E−03 CaseOnly add CHD rs3000490 15/72/72 16/91/117 1.25 0.91 1.72 1.72E−01 CaseOnly add CHD rs4289236 8/61/115 4/67/176 1.49 1.04 2.13 3.03E−02 Caseonly add CVD rs2060411 17/71/71 12/95/117 1.44 1.03 2.00 3.07E−02 CaseOnly add CHD rs4643388 20/80/84 16/98/133 1.38 1.02 1.86 3.61E−02 Caseonly add CVD rs9436636 27/81/51 28/102/93 1.36 1.00 1.83 4.76E−02 CaseOnly add CHD rs7327364 29/81/74 37/136/74 0.64 0.43 0.96 3.08E−02 Caseonly dom CVD rs2626130 37/89/58 30/122/95 1.37 1.04 1.82 2.74E−02 Caseonly add CVD rs4611134 55/79/50 55/119/73 1.56 1.01 2.43 4.71E−02 Caseonly rec CVD rs17716275 1/20/138 0/14/210 2.26 1.11 4.62 2.45E−02 CaseOnly dom CHD rs7094941 14/64/81 27/116/81 0.66 0.48 0.91 1.06E−02 CaseOnly add CHD rs1076733 34/81/69 40/139/68 0.62 0.41 0.94 2.34E−02 Caseonly dom CVD rs2290193 7/80/97 26/100/121 0.35 0.15 0.83 1.66E−02 Caseonly rec CVD rs10103297 1/14/144 2/6/216 2.74 1.13 6.65 2.60E−02 CaseOnly dom CHD rs12657484 18/85/56 19/95/110 1.76 1.16 2.68 8.14E−03 CaseOnly dom CHD rs7910196 4/54/101 2/54/168 1.72 1.14 2.59 1.01E−02 CaseOnly add CHD rs7767024 2/61/121 4/50/193 1.69 1.13 2.51 1.05E−02 Caseonly add CVD rs1474396 32/100/52 31/118/98 1.73 1.14 2.62 9.39E−03 Caseonly dom CVD rs1182878 41/80/63 57/137/53 0.75 0.57 0.99 4.36E−02 Caseonly add CVD rs2483641 2/17/140 3/44/177 0.50 0.28 0.89 1.93E−02 CaseOnly dom CHD rs453625 1/17/141 2/43/179 0.54 0.31 0.95 3.10E−02 CaseOnly add CHD rs7497613 29/102/53 74/125/48 0.43 0.26 0.70 6.18E−04 Caseonly rec CVD rs2129571 0/19/140 3/52/169 0.40 0.23 0.70 1.30E−03 CaseOnly add CHD rs16861467 0/18/141 3/53/168 0.37 0.21 0.65 5.20E−04 CaseOnly add CHD rs10088524 1/41/142 3/32/212 1.80 1.09 2.96 2.13E−02 Caseonly dom CVD rs10875941 2/55/101 20/97/107 0.51 0.34 0.78 1.71E−03 CaseOnly dom CHD rs7616936 0/42/117 2/28/194 2.30 1.36 3.88 1.83E−03 CaseOnly dom CHD rs6911817 0/12/172 0/3/244 5.32 1.47 19.19 1.08E−02 Caseonly add CVD rs9658127 0/12/172 0/3/244 5.32 1.47 19.19 1.08E−02 Caseonly add CVD

TABLE 5 allele A1 allele Meta-analysis CARE (non- A2 OR OR P value OR OR Marker ref) (ref) OR L95 U95 (random) Prava Count Placebo Count OR L95 U95 P value Source rs11124322 A G 0.64 0.50 0.82 3.92E−04 292/733/469 322/733/416 0.70 0.51 0.95 2.18E−02 cohort rs10193722 C A 71/167/119 100/238/106 0.62 0.46 0.85 3.11E−03 Caseonly rs1051344 C G 0.64 0.51 0.80 1.07E−04 262/694/537 253/734/484 0.64 0.48 0.86 2.62E−03 cohort rs1051334 C A 52/149/156 73/230/140 0.58 0.44 0.78 3.23E−04 Caseonly rs2030057 T C 0.60 0.47 0.75 1.18E−05 47/425/964 61/410/959 0.56 0.42 0.75 7.88E−05 cohort rs10740308 A C 7/79/214 28/125/229 0.61 0.47 0.81 5.28E−04 Caseonly rs10831416 G A 1.73 1.24 2.42 1.26E−03 253/707/534 233/665/573 1.61 1.08 2.42 2.09E−02 cohort rs10831415 G A 62/144/94 50/179/153 1.77 1.17 2.67 7.05E−03 Caseonly rs4657668 G A 1.34 1.14 1.58 4.33E−04 255/675/522 213/689/532 1.32 1.08 1.61 7.53E−03 cohort rs1229430 G A 77/170/110 59/212/173 1.39 1.13 1.70 1.57E−03 Caseonly rs6497117 C T 0.52 0.38 0.70 2.59E−05 308/744/395 328/721/382 0.58 0.40 0.85 5.29E−03 cohort rs12914132 A G 52/159/89 97/179/106 0.60 0.41 0.87 7.98E−03 Caseonly rs1529806 G A 1.42 1.17 1.73 3.89E−04 130/570/752 94/561/779 1.43 1.12 1.82 4.17E−03 cohort rs1594887 G A 30/126/143 19/134/229 1.56 1.22 2.00 3.71E−04 Caseonly rs3732788 C T 0.48 0.32 0.71 2.39E−04 16/212/1267 14/275/1180 0.56 0.38 0.81 2.46E−03 cohort rs16861476 C A 1/35/263 5/83/294 0.47 0.31 0.71 2.92E−04 Caseonly rs1773549 C T 1.45 1.18 1.78 3.68E−04 95/544/812 81/527/826 1.49 1.17 1.91 1.44E−03 cohort rs1737478 A G 29/125/146 20/130/232 1.54 1.20 1.96 6.39E−04 Caseonly rs1560901 A G 1.41 1.16 1.71 5.74E−04 125/573/753 94/551/789 1.41 1.10 1.80 5.75E−03 cohort rs2196180 A G 28/126/146 19/132/231 1.53 1.20 1.96 7.53E−04 Caseonly rs231355 G C 1.38 1.16 1.64 2.11E−04 357/708/387 325/704/403 1.30 1.05 1.61 1.65E−02 cohort rs231358 G A 82/159/59 78/196/108 1.39 1.11 1.74 4.61E−03 Caseonly rs10875941 C T 0.64 0.47 0.88 5.81E−03 118/582/795 141/581/748 0.73 0.54 0.99 4.41E−02 cohort rs2335451 A C 21/111/168 44/157/181 0.70 0.51 0.95 2.33E−02 Caseonly rs9834251 G T 1.75 1.29 2.38 3.12E−04 291/722/482 247/700/524 1.64 1.11 2.41 1.22E−02 cohort rs2358931 G A 66/175/114 47/235/159 1.94 1.29 2.92 1.45E−03 Caseonly rs4765531 A C 0.67 0.54 0.81 6.11E−05 91/566/795 113/564/757 0.70 0.55 0.90 5.60E−03 cohort rs2593270 A G 13/111/176 33/162/187 0.69 0.53 0.88 3.56E−03 Caseonly rs4765531 A C 0.66 0.54 0.81 4.85E−05 91/566/795 113/564/757 0.70 0.55 0.90 5.60E−03 cohort rs2656824 A G 12/111/177 31/157/194 0.71 0.55 0.92 8.72E−03 Caseonly rs302290 C T 1.56 1.24 1.97 1.65E−04 102/571/775 113/529/790 1.46 1.10 1.94 9.55E−03 cohort rs302296 G A 28/144/183 31/140/273 1.54 1.15 2.05 3.34E−03 Caseonly rs3806005 A C 2.25 1.58 3.21 8.04E−06 10/239/1203 9/207/1218 2.03 1.32 3.11 1.26E−03 cohort rs3793048 A C 3/68/228 6/47/328 2.21 1.44 3.41 3.17E−04 Caseonly rs1560901 A G 1.40 1.16 1.71 6.32E−04 125/573/753 94/551/789 1.41 1.10 1.80 5.75E−03 cohort rs3861810 G A 28/127/145 19/132/231 1.54 1.20 1.97 5.90E−04 Caseonly rs7179134 A G 3.72 2.01 6.89 2.88E−05 rs4128766 A G 65/454/933 68/457/909 3.92 1.70 9.02 1.31E−03 cohort rs2148575 A G 0.35 0.20 0.59 1.24E−04 7/96/1392 12/97/1362 0.36 0.19 0.67 1.17E−03 cohort rs4242084 A C 0/12/345 4/38/402 0.26 0.12 0.55 4.34E−04 Caseonly rs5756670 G A 1.75 1.33 2.29 5.75E−05 320/688/443 294/689/451 1.82 1.29 2.56 6.67E−04 cohort rs4328731 A C 66/165/69 72/177/133 1.77 1.26 2.51 1.15E−03 Caseonly rs7094941 G A 0.74 0.61 0.89 1.16E−03 160/670/665 188/640/643 0.78 0.63 0.98 3.41E−02 cohort rs4980176 C A 26/131/143 54/177/151 0.75 0.59 0.95 1.67E−02 Caseonly rs1851830 A G 1.73 1.24 2.42 1.29E−03 218/673/560 175/648/611 1.70 1.12 2.60 1.36E−02 cohort rs6550706 A G 60/168/129 42/210/192 1.91 1.25 2.93 2.76E−03 Caseonly rs10275879 T A 0.50 0.36 0.71 8.02E−05 349/746/400 363/746/362 0.44 0.30 0.65 3.29E−05 cohort rs6950121 A C 44/168/88 105/188/89 0.44 0.29 0.66 6.20E−05 Caseonly rs7765440 T C 2.00 1.49 2.68 4.37E−06 11/210/1229 16/215/1203 1.82 1.26 2.62 1.28E−03 cohort rs7751843 A G 5/59/236 3/52/327 1.69 1.16 2.46 6.03E−03 Caseonly rs2030057 T C 0.60 0.47 0.75 1.18E−05 47/425/964 61/410/959 0.56 0.42 0.75 7.88E−05 cohort rs7901888 A C 6/80/214 27/124/231 0.62 0.47 0.82 6.91E−04 Caseonly rs3998860 A G 0.61 0.49 0.77 2.29E−05 129/851/1903 75/416/941 0.58 0.44 0.76 7.97E−05 cohort rs7913568 G A 6/79/215 31/121/228 0.57 0.43 0.76 9.24E−05 Caseonly rs6931627 G A 0.74 0.63 0.87 3.01E−04 237/758/500 279/720/472 0.75 0.61 0.92 5.65E−03 cohort rs9467561 A C 54/164/139 95/221/128 0.71 0.58 0.87 9.73E−04 Caseonly rs912366 G A 1.61 1.23 2.11 6.04E−04 31/393/1071 21/357/1093 1.60 1.14 2.24 6.82E−03 cohort rs9554735 A G 5/95/200 7/78/297 1.77 1.26 2.49 1.09E−03 Caseonly WOSCOPS OR OR End- Marker Prava Count Placebo Count OR L95 U95 P value Source Model point rs11124322 dom CVD rs10193722 32/81/71 50/133/64 0.55 0.36 0.83 4.27E−03 Caseonly dom CVD rs1051344 431/1243/981 416/1234/1008 0.64 0.45 0.92 1.47E−02 cohort dom CVD rs1051334 19/85/80 41/132/74 0.58 0.39 0.86 7.16E−03 Caseonly dom CVD rs2030057 add CHD rs10740308 3/41/115 6/79/139 0.66 0.44 0.99 4.49E−02 Caseonly add CHD rs10831416 rec CHD rs10831415 30/89/40 23/118/83 2.02 1.12 3.63 1.97E−02 Caseonly rec CHD rs4657668 add CVD rs1229430 33/87/64 31/105/111 1.38 1.05 1.82 2.11E−02 Caseonly add CVD rs6497117 rec CHD rs12914132 26/89/44 68/114/40 0.42 0.25 0.70 9.73E−04 Caseonly rec CHD rs1529806 add CHD rs1594887 17/72/70 13/95/116 1.42 1.02 1.97 3.63E−02 Caseonly add CHD rs3732788 add CHD rs16861476 0/18/141 3/53/168 0.37 0.21 0.65 5.20E−04 Caseonly add CHD rs1773549 add CHD rs1737478 6/62/91 8/66/150 1.36 0.94 1.95 9.86E−02 Caseonly add CHD rs1560901 add CHD rs2196180 17/71/71 13/94/117 1.41 1.02 1.95 3.97E−02 Caseonly add CHD rs231355 add CHD rs231358 58/70/31 53/103/68 1.54 1.16 2.04 2.94E−03 Caseonly add CHD rs10875941 dom CHD rs2335451 3/55/101 20/96/108 0.53 0.35 0.80 2.80E−03 Caseonly dom CHD rs9834251 rec CVD rs2358931 44/73/63 35/109/100 1.96 1.19 3.21 8.02E−03 Caseonly rec CVD rs4765531 add CHD rs2593270 7/52/100 28/84/112 0.61 0.44 0.84 2.90E−03 Caseonly add CHD rs4765531 add CHD rs2656824 7/51/101 28/84/112 0.60 0.43 0.83 2.14E−03 Caseonly add CHD rs302290 dom CVD rs302296 7/76/101 12/68/167 1.79 1.20 2.66 4.39E−03 Caseonly dom CVD rs3806005 dom CHD rs3793048 1/29/129 2/15/207 2.83 1.50 5.36 1.36E−03 Caseonly dom CHD rs1560901 add CHD rs3861810 17/72/70 14/94/116 1.40 1.01 1.93 4.41E−02 Caseonly add CHD rs7179134 102/858/1693 109/872/1674 3.50 1.40 8.72 7.28E−03 cohort rec CVD rs4128766 15/62/107 7/86/154 3.18 1.27 8.01 1.40E−02 Caseonly rec CVD rs2148575 dom CVD rs4242084 0/4/180 0/16/231 0.31 0.10 0.94 3.92E−02 Caseonly dom CVD rs5756670 dom CHD rs4328731 27/88/44 43/97/84 1.64 1.05 2.56 2.96E−02 Caseonly dom CHD rs7094941 add CHD rs4980176 13/64/81 26/117/81 0.64 0.47 0.89 8.15E−03 Caseonly add CHD rs1851830 rec CVD rs6550706 34/79/71 28/94/124 1.78 1.03 3.06 3.84E−02 Caseonly rec CVD rs10275879 rec CHD rs6950121 27/83/49 55/99/70 0.63 0.38 1.05 7.68E−02 Caseonly rec CHD rs7765440 add CHD rs7751843 2/41/115 1/28/194 2.38 1.44 3.93 7.17E−04 Caseonly add CHD rs2030057 add CHD rs7901888 3/41/115 6/79/139 0.66 0.44 0.99 4.49E−02 Caseonly add CHD rs3998860 add CHD rs7913568 3/44/112 6/80/138 0.70 0.47 1.05 8.17E−02 Caseonly add CHD rs6931627 add CVD rs9467561 23/94/67 55/119/73 0.72 0.54 0.95 1.92E−02 Caseonly add CVD rs912366 dom CHD rs9554735 6/46/107 6/45/173 1.64 1.04 2.58 3.48E−02 Caseonly dom CHD

TABLE 6 allele A1 allele Meta-analysis CARE (non- A2 OR OR P value Placebo OR OR Marker ref) (ref) OR L95 U95 (random) Prava Count Count OR L95 U95 rs13129010 A G 1.65 1.30 2.08 3.28E−05 7/89/204 8/76/298 1.69 1.19 2.39 rs4242281 A C 1.93 1.41 2.64 3.42E−05 51/156/149 33/215/196 2.12 1.33 3.38 rs6474228 A G 1.54 1.25 1.90 5.17E−05 17/120/163 27/108/247 1.55 1.14 2.12 rs4240808 A G 0.61 0.48 0.77 5.59E−05 66/181/110 115/215/114 0.63 0.45 0.89 rs13126170 A G 0.65 0.52 0.80 6.32E−05 6/89/262 13/146/285 0.64 0.47 0.87 rs7916629 G A 2.09 1.45 2.99 6.46E−05 43/136/176 25/184/235 2.33 1.39 3.92 rs11721179 A C 0.64 0.51 0.80 6.95E−05 11/85/261 21/140/283 0.65 0.48 0.89 rs2993156 A G 0.66 0.54 0.81 7.06E−05 9/96/252 29/157/257 0.57 0.42 0.77 rs10774580 A G 0.65 0.53 0.81 8.25E−05 48/125/127 56/196/130 0.72 0.53 0.99 rs16885715 G A 1.56 1.25 1.94 8.49E−05 17/95/188 15/85/282 1.71 1.23 2.38 rs4870109 A G 1.86 1.36 2.53 8.51E−05 51/156/148 35/213/194 2.01 1.27 3.19 rs17688430 A C 0.69 0.58 0.83 9.66E−05 7/96/254 18/155/271 0.65 0.50 0.85 rs7332076 A G 2.06 1.43 2.96 9.98E−05 35/147/174 26/195/223 1.83 1.07 3.13 rs694780 G A 0.55 0.41 0.75 1.26E−04 38/157/105 72/175/135 0.61 0.40 0.95 rs4836745 A G 0.68 0.56 0.83 1.30E−04 27/138/192 51/193/200 0.72 0.54 0.95 rs7018577 A G 1.50 1.22 1.86 1.44E−04 18/122/160 19/130/233 1.34 0.98 1.82 rs11585647 A G 0.62 0.48 0.79 1.46E−04 5/64/288 11/107/326 0.67 0.47 0.94 rs4420312 A G 0.66 0.54 0.82 1.51E−04 17/87/196 20/140/222 0.73 0.53 1.00 rs7449527 G A 1.52 1.21 1.91 2.61E−04 13/79/208 13/79/290 1.42 1.01 1.99 rs7839562 A G 1.52 1.21 1.91 2.75E−04 47/177/76 62/196/124 1.45 1.04 2.04 rs2655222 A G 0.29 0.15 0.57 3.05E−04 6/120/174 20/114/248 0.38 0.15 0.97 rs2616548 G A 1.57 1.23 2.00 3.23E−04 10/73/217 9/75/298 1.43 1.00 2.05 rs10497883 G A 0.71 0.59 0.86 3.37E−04 10/90/200 20/134/228 0.75 0.57 0.99 rs6998016 A G 3.99 1.83 8.72 5.20E−04 13/89/198 6/126/250 2.76 1.02 7.46 rs11148285 A G 1.88 1.32 2.70 5.49E−04 37/133/187 27/182/235 1.74 1.03 2.95 rs7305949 G A 2.22 1.62 3.04 5.97E−07 201/674/620 171/681/619 2.50 1.57 4.00 rs264122 A G 0.62 0.51 0.76 2.80E−06 183/654/658 200/642/629 0.54 0.40 0.73 rs1009748 A G 1.37 1.19 1.57 6.63E−06 214/663/617 176/665/629 1.35 1.10 1.65 rs1336400 A G 1.60 1.30 1.96 6.96E−06 306/1284/1371 152/631/686 1.87 1.38 2.54 rs2108425 A G 0.63 0.51 0.77 7.94E−06 181/652/661 201/643/624 0.55 0.40 0.74 rs2327412 G A 1.37 1.19 1.57 1.10E−05 215/665/615 183/664/623 1.34 1.10 1.64 rs17002013 A G 1.56 1.28 1.91 1.16E−05 89/477/929 61/487/923 1.63 1.22 2.17 rs1015199 G A 1.72 1.35 2.20 1.49E−05 18/281/1196 22/266/1183 1.63 1.14 2.33 rs7078016 C A 1.54 1.27 1.87 1.49E−05 282/1256/1343 136/621/675 1.68 1.26 2.23 rs6585412 A G 1.53 1.26 1.86 1.66E−05 281/1256/1347 136/618/678 1.68 1.26 2.23 rs198476 G A 1.67 1.32 2.11 1.91E−05 340/768/384 326/759/385 1.58 1.09 2.30 rs2648694 A G 1.98 1.44 2.72 2.42E−05 172/636/683 156/625/686 2.00 1.25 3.19 rs10945874 A G 1.58 1.28 1.96 2.89E−05 19/277/1197 23/270/1178 1.72 1.25 2.36 rs1190706 A C 0.67 0.56 0.81 3.38E−05 176/666/653 170/666/635 0.61 0.46 0.81 rs3763978 G C 0.75 0.66 0.86 3.75E−05 259/676/559 243/723/503 0.76 0.62 0.92 rs11138314 G A 0.64 0.51 0.79 3.78E−05 57/646/2183 29/302/1103 0.67 0.48 0.92 rs13107334 C A 0.65 0.53 0.80 4.01E−05 104/895/1967 52/452/967 0.67 0.49 0.90 rs6685920 A G 1.60 1.28 2.01 4.01E−05 18/382/1092 17/347/1104 1.83 1.32 2.54 rs2616552 A C 1.42 1.20 1.68 4.06E−05 97/494/904 95/475/901 1.39 1.09 1.78 rs2110564 A C 0.66 0.54 0.81 5.17E−05 260/679/556 227/753/490 0.76 0.57 1.01 rs10012485 G A 0.66 0.54 0.81 5.34E−05 66/494/931 58/525/885 0.76 0.57 1.01 rs1798093 G A 1.75 1.33 2.29 5.98E−05 241/690/564 183/758/530 1.69 1.10 2.61 rs4787415 A G 0.60 0.46 0.77 6.30E−05 323/714/414 325/743/364 0.64 0.44 0.92 rs11734256 G A 0.61 0.48 0.78 7.05E−05 645/1484/756 324/732/378 0.54 0.38 0.78 rs1266489 A G 0.67 0.55 0.81 7.06E−05 257/656/582 256/677/538 0.63 0.47 0.84 rs238250 A C 1.46 1.21 1.76 7.50E−05 62/704/2117 27/322/1083 1.65 1.23 2.22 rs2588350 A G 0.72 0.61 0.85 7.53E−05 57/508/928 79/507/883 0.69 0.54 0.87 rs498657 G A 1.47 1.21 1.77 9.18E−05 43/443/1007 46/403/1020 1.59 1.20 2.11 rs6427807 C A 0.68 0.56 0.83 9.43E−05 477/1399/1084 237/700/529 0.70 0.53 0.93 rs619825 G A 0.56 0.41 0.75 1.01E−04 238/719/536 247/673/551 0.62 0.41 0.94 rs9478241 G A 1.85 1.36 2.52 1.02E−04 193/661/640 158/705/605 1.86 1.18 2.95 rs1727746 A G 1.47 1.21 1.79 1.02E−04 216/667/612 169/670/632 1.57 1.18 2.08 rs2505039 A G 0.76 0.66 0.87 1.04E−04 370/670/455 300/766/405 0.69 0.56 0.86 rs4472926 G A 0.66 0.54 0.82 1.05E−04 154/685/656 177/679/615 0.74 0.54 1.00 rs6539231 A G 0.65 0.52 0.81 1.07E−04 326/757/412 356/736/379 0.62 0.46 0.86 rs7959965 A G 0.76 0.66 0.87 1.09E−04 328/718/448 319/766/386 0.77 0.64 0.94 rs974950 A G 0.67 0.55 0.82 1.13E−04 259/677/558 228/750/492 0.77 0.57 1.03 rs1524962 A G 0.72 0.60 0.85 1.14E−04 81/566/848 122/580/767 0.63 0.49 0.82 rs17821383 A C 0.30 0.16 0.55 1.15E−04 148/947/1791 78/476/880 0.24 0.09 0.64 rs10518335 A G 0.67 0.55 0.82 1.19E−04 59/493/942 57/525/889 0.76 0.57 1.02 rs12265891 A C 1.66 1.28 2.15 1.21E−04 690/1425/771 339/726/369 1.65 1.16 2.36 rs4807536 A G 2.00 1.40 2.85 1.22E−04 4/144/1346 7/126/1338 2.20 1.33 3.64 rs9914580 A G 0.64 0.51 0.80 1.22E−04 34/363/1098 29/380/1062 0.72 0.51 1.01 rs646749 A G 0.56 0.41 0.75 1.24E−04 236/723/536 239/683/548 0.62 0.41 0.95 rs1003322 A C 1.51 1.22 1.86 1.25E−04 72/516/907 67/505/899 1.57 1.15 2.13 rs4660234 A G 1.56 1.24 1.96 1.26E−04 18/382/1095 17/347/1105 1.86 1.31 2.65 rs4038018 G A 0.65 0.52 0.81 1.27E−04 304/693/498 271/747/453 0.65 0.47 0.90 rs7710039 G A 0.68 0.56 0.83 1.32E−04 137/588/769 134/612/725 0.69 0.52 0.91 rs13150189 A G 1.48 1.21 1.81 1.33E−04 111/911/1941 43/443/983 1.38 1.04 1.85 rs12646525 A G 0.68 0.55 0.83 1.34E−04 65/504/926 60/526/885 0.75 0.57 1.01 rs2113334 A G 0.41 0.26 0.65 1.36E−04 180/1056/1730 97/534/840 0.43 0.23 0.83 rs251817 A G 2.19 1.46 3.27 1.37E−04 0/84/1359 3/83/1341 2.09 1.15 3.80 rs2574 C G 1.53 1.23 1.91 1.39E−04 377/740/378 338/715/418 1.48 1.07 2.04 rs12679254 A G 0.68 0.56 0.83 1.40E−04 146/640/709 167/647/657 0.65 0.49 0.87 rs12341095 A G 2.10 1.43 3.09 1.47E−04 138/583/774 98/607/766 2.35 1.30 4.27 rs17048681 C A 1.31 1.14 1.51 1.47E−04 239/709/546 219/690/562 1.26 1.03 1.54 rs1942876 A G 0.56 0.42 0.76 1.48E−04 228/724/543 237/679/554 0.62 0.40 0.95 rs2657940 A G 1.40 1.18 1.66 1.52E−04 82/530/882 59/504/908 1.43 1.11 1.85 rs494111 G A 0.57 0.42 0.76 1.54E−04 237/727/531 241/690/540 0.63 0.42 0.96 rs2060022 G A 0.64 0.51 0.81 1.59E−04 320/753/422 364/713/393 0.58 0.41 0.81 rs7338174 A G 2.16 1.45 3.22 1.59E−04 3/121/1371 0/101/1370 2.01 1.13 3.57 rs12048902 G A 0.76 0.66 0.88 1.61E−04 220/701/574 246/692/532 0.74 0.60 0.90 rs6746182 A G 1.49 1.21 1.83 1.63E−04 99/581/814 92/528/851 1.52 1.12 2.06 rs7276749 A C 0.46 0.31 0.69 1.68E−04 3/109/1378 5/133/1328 0.37 0.19 0.69 rs198460 G A 1.56 1.24 1.97 1.68E−04 339/773/382 327/761/382 1.59 1.09 2.30 rs7785499 A G 1.53 1.23 1.92 1.75E−04 362/729/404 343/725/403 1.41 1.02 1.96 rs996022 C A 0.57 0.42 0.76 1.76E−04 227/724/543 237/677/555 0.63 0.41 0.96 rs7222186 A G 0.64 0.51 0.81 1.79E−04 34/352/1109 25/379/1067 0.73 0.52 1.04 rs198464 G A 1.57 1.24 1.99 1.80E−04 349/771/374 336/765/369 1.44 1.00 2.07 rs16934059 C A 0.68 0.55 0.83 1.80E−04 197/673/625 205/670/595 0.75 0.55 1.02 rs1566221 G A 0.56 0.42 0.76 1.84E−04 14/347/2605 8/175/1288 0.59 0.39 0.88 rs8129810 A G 0.46 0.31 0.69 1.85E−04 3/108/1384 5/133/1333 0.37 0.19 0.69 rs1344081 G A 1.45 1.19 1.77 1.89E−04 60/459/976 74/439/958 1.45 1.09 1.93 rs7918692 A G 1.54 1.23 1.94 1.96E−04 26/352/1117 21/324/1126 1.47 1.07 2.03 rs4686740 A G 1.55 1.23 1.95 2.04E−04 341/721/433 302/709/460 1.42 1.02 1.99 rs12817873 A G 0.77 0.67 0.88 2.05E−04 262/693/538 249/739/481 0.76 0.62 0.93 rs7508 G A 1.48 1.20 1.82 2.08E−04 125/612/758 120/550/801 1.42 1.05 1.93 rs271046 A G 0.57 0.43 0.77 2.13E−04 189/670/636 216/652/603 0.51 0.33 0.78 rs2011318 A G 0.64 0.51 0.81 2.15E−04 21/274/1155 18/268/1147 0.67 0.47 0.95 rs1136046 A G 1.48 1.20 1.83 2.29E−04 59/663/2244 29/317/1125 1.64 1.23 2.18 rs1450092 G A 0.69 0.57 0.84 2.29E−04 43/415/1037 43/464/962 0.63 0.47 0.84 rs7070244 G A 1.45 1.19 1.78 2.37E−04 37/350/1107 32/325/1114 1.42 1.07 1.88 rs892162 G A 0.60 0.46 0.79 2.39E−04 273/736/485 279/695/496 0.64 0.43 0.96 rs6563805 A G 0.65 0.52 0.82 2.41E−04 42/350/1102 35/383/1052 0.76 0.56 1.04 rs9906737 G A 0.65 0.52 0.82 2.42E−04 35/355/1104 30/376/1064 0.71 0.50 1.01 rs475420 G A 1.63 1.25 2.12 2.49E−04 20/235/1237 8/198/1263 1.79 1.24 2.59 rs17644708 G A 0.51 0.36 0.73 2.61E−04 156/606/732 168/601/702 0.58 0.36 0.94 rs7067780 A G 1.53 1.22 1.91 2.61E−04 33/353/1109 30/321/1119 1.43 1.03 1.97 rs4773 A G 0.69 0.56 0.84 2.68E−04 249/694/552 250/712/509 0.65 0.48 0.87 rs6742894 G A 1.53 1.22 1.92 2.69E−04 395/755/343 335/732/404 1.33 0.96 1.85 rs1045916 G A 0.74 0.62 0.87 2.70E−04 225/1125/1533 118/555/760 0.67 0.52 0.86 rs6435378 A G 0.67 0.53 0.83 2.76E−04 298/688/509 264/756/451 0.70 0.51 0.97 rs13411119 A G 1.44 1.18 1.75 2.78E−04 121/612/762 118/565/788 1.33 1.01 1.76 rs1531842 A C 0.68 0.56 0.84 2.79E−04 330/1271/1365 180/641/650 0.65 0.48 0.88 rs9857 G A 0.74 0.63 0.87 2.85E−04 96/554/844 120/608/741 0.68 0.54 0.86 rs9960 A G 1.47 1.19 1.80 2.88E−04 54/483/958 41/442/987 1.55 1.15 2.08 rs13103899 G A 0.67 0.54 0.83 2.88E−04 81/850/1955 39/434/961 0.70 0.52 0.95 rs6848512 G A 0.66 0.53 0.83 2.88E−04 316/740/394 329/731/373 0.75 0.55 1.02 rs10181805 A C 1.36 1.15 1.61 2.95E−04 64/473/957 54/454/963 1.31 1.02 1.67 rs1129570 C A 1.42 1.17 1.71 3.02E−04 47/455/950 50/410/974 1.34 1.01 1.77 rs9986576 A C 1.77 1.30 2.41 3.07E−04 349/1376/1241 156/710/605 1.79 1.13 2.84 rs1352236 A G 0.44 0.28 0.69 3.07E−04 133/614/746 145/609/716 0.59 0.34 1.03 rs7770578 A G 0.65 0.52 0.82 3.13E−04 20/302/1128 20/324/1087 0.69 0.50 0.97 rs2748901 G A 1.58 1.23 2.03 3.14E−04 326/750/419 314/702/454 1.57 1.07 2.30 rs1155875 G A 0.77 0.67 0.89 3.21E−04 286/710/499 298/652/521 0.81 0.66 1.01 rs675163 C A 0.67 0.54 0.83 3.25E−04 15/305/1175 25/315/1131 0.70 0.51 0.95 rs1068705 G A 0.66 0.53 0.83 3.29E−04 335/738/421 342/724/405 0.67 0.48 0.95 rs1505469 G A 1.50 1.20 1.88 3.45E−04 26/322/1147 21/320/1130 1.36 0.99 1.87 rs623400 A G 0.70 0.57 0.85 3.56E−04 107/559/786 115/547/772 0.77 0.58 1.03 rs6040760 G A 1.47 1.19 1.82 3.60E−04 128/565/801 110/562/799 1.72 1.30 2.28 rs17310169 A G 0.68 0.55 0.84 3.68E−04 47/422/1025 63/453/955 0.65 0.48 0.89 rs7623808 A C 4.25 1.92 9.43 3.74E−04 44/369/1081 37/324/1109 4.02 1.31 12.33 rs77638540 A G 0.48 0.32 0.72 3.78E−04 3/110/1382 5/129/1337 0.38 0.21 0.71 rs581401 A G 0.59 0.44 0.79 3.85E−04 239/715/539 240/683/548 0.62 0.41 0.94 rs4251580 A G 0.69 0.56 0.84 3.90E−04 34/355/1106 29/377/1065 0.78 0.59 1.04 rs603940 G A 0.59 0.44 0.79 3.91E−04 238/721/534 242/677/552 0.62 0.40 0.94 rs13117043 G A 1.50 1.20 1.88 4.01E−04 43/468/984 42/389/1039 1.29 0.93 1.79 rs3800202 A G 0.48 0.32 0.72 4.10E−04 3/114/1375 2/136/1329 0.39 0.20 0.76 rs10738948 A G 0.76 0.65 0.88 4.18E−04 202/706/587 231/708/530 0.82 0.65 1.02 rs623584 A G 0.59 0.45 0.79 4.21E−04 238/724/532 243/682/546 0.62 0.41 0.94 rs9557509 A G 1.49 1.20 1.87 4.24E−04 27/383/1084 24/334/1112 1.70 1.21 2.39 rs11668038 G A 1.35 1.14 1.60 4.29E−04 168/985/1731 79/486/868 1.31 1.02 1.69 rs10802865 A C 1.29 1.12 1.49 4.62E−04 697/1481/705 328/745/360 1.40 1.12 1.74 rs17035071 A G 1.44 1.17 1.77 5.05E−04 49/471/975 57/435/979 1.52 1.11 2.09 rs1439269 A G 1.39 1.16 1.68 5.20E−04 118/612/765 113/587/770 1.29 1.02 1.64 rs208025 A G 1.41 1.16 1.72 5.61E−04 93/537/861 96/473/897 1.30 0.98 1.72 rs12608167 G A 0.67 0.53 0.84 5.65E−04 21/337/1137 26/366/1078 0.70 0.50 0.98 rs133871 G A 0.70 0.57 0.85 5.74E−04 173/606/716 182/638/651 0.81 0.60 1.09 rs7068975 A C 1.65 1.24 2.19 5.82E−04 11/240/1244 9/204/1258 1.69 1.10 2.59 rs1866386 A G 0.74 0.62 0.88 5.84E−04 70/500/925 93/548/829 0.69 0.53 0.88 rs1580713 A G 1.57 1.21 2.03 6.11E−04 552/1477/937 251/764/456 1.52 1.04 2.22 rs936671 G A 0.70 0.57 0.86 6.61E−04 93/549/852 109/559/801 0.73 0.54 0.99 rs3732136 A G 1.51 1.19 1.91 6.62E−04 118/604/772 117/568/786 1.32 0.98 1.79 rs17718867 A G 0.72 0.59 0.87 6.84E−04 50/407/1038 46/464/961 0.67 0.51 0.89 rs5764592 G A 1.53 1.20 1.95 7.02E−04 23/261/1211 18/240/1212 1.40 0.99 1.98 rs2880563 G A 1.41 1.16 1.72 7.07E−04 119/563/770 92/541/801 1.31 0.98 1.74 rs1564078 G A 0.78 0.68 0.90 7.07E−04 279/650/563 205/735/530 0.73 0.58 0.90 rs10817479 A G 1.66 1.24 2.23 7.22E−04 0/203/1280 0/157/1305 1.83 1.19 2.81 rs478859 A G 1.26 1.10 1.45 7.28E−04 341/724/430 324/705/442 1.20 0.99 1.46 rs10106852 G A 1.64 1.23 2.19 7.44E−04 190/675/630 167/704/599 1.40 0.92 2.14 rs12659030 A G 1.43 1.16 1.75 7.50E−04 105/584/806 85/532/854 1.48 1.09 2.00 rs1536506 A G 1.49 1.18 1.89 7.74E−04 369/716/408 271/747/453 1.57 1.11 2.23 rs2184393 G A 0.70 0.57 0.86 7.76E−04 437/1361/1166 218/711/540 0.66 0.48 0.90 rs11077308 G A 1.47 1.17 1.84 7.81E−04 42/404/1005 33/375/1026 1.26 0.90 1.75 rs7915250 C G 0.71 0.58 0.87 8.35E−04 225/681/589 260/682/529 0.69 0.51 0.92 rs4689078 G A 1.27 1.10 1.46 8.63E−04 319/719/454 266/733/469 1.23 1.01 1.50 rs2869680 A G 0.75 0.64 0.89 9.44E−04 68/511/872 79/508/847 0.81 0.64 1.03 rs12286877 A G 2.18 1.37 3.45 9.89E−04 0/150/2726 0/62/1368 2.20 1.07 4.55 rs10460737 A G 0.24 0.08 0.70 9.13E−03 0/58/1394 1/68/1365 0.43 0.20 0.92 WOSCOPS CARE OR OR Marker P value Source Prava Count Placebo Count OR L95 U95 P value Source rs13129010 3.07E−03 caseonly 4/48/107 2/44/178 1.90 1.19 3.03 6.81E−03 caseonly rs4242281 1.64E−03 caseonly 21/76/87 20/109/118 1.46 0.76 2.79 2.51E−01 caseonly rs6474228 5.78E−03 caseonly 14/62/83 8/66/150 1.83 1.21 2.79 4.63E−03 caseonly rs4240808 8.21E−03 caseonly 32/99/53 65/118/64 0.61 0.38 0.98 4.06E−02 caseonly rs13126170 4.55E−03 caseonly 5/53/126 9/82/156 0.78 0.52 1.17 2.36E−01 caseonly rs7916629 1.37E−03 caseonly 18/75/90 15/98/130 1.66 0.81 3.41 1.64E−01 caseonly rs11721179 7.62E−03 caseonly 2/34/148 7/65/175 0.60 0.38 0.95 2.87E−02 caseonly rs2993156 2.36E−04 caseonly 8/58/118 14/92/141 0.76 0.51 1.13 1.73E−01 caseonly rs10774580 4.35E−02 caseonly 25/64/70 37/119/68 0.56 0.37 0.86 7.45E−03 caseonly rs16885715 1.34E−03 caseonly 7/49/103 6/52/166 1.58 1.01 2.46 4.38E−02 caseonly rs4870109 2.98E−03 caseonly 21/75/87 20/109/118 1.47 0.77 2.80 2.45E−01 caseonly rs17688430 1.46E−03 caseonly 5/50/129 10/86/151 0.71 0.50 1.01 5.62E−02 caseonly rs7332076 2.75E−02 caseonly 22/69/93 15/103/129 2.18 1.09 4.34 2.70E−02 caseonly rs694780 2.89E−02 caseonly 20/76/63 43/103/78 0.62 0.35 1.10 1.02E−01 caseonly rs4836745 1.94E−02 caseonly 17/78/89 25/128/94 0.65 0.44 0.97 3.26E−02 caseonly rs7018577 6.27E−02 caseonly 13/75/71 13/75/136 1.94 1.28 2.94 1.68E−03 caseonly rs11585647 2.23E−02 caseonly 5/22/157 1/50/196 0.67 0.40 1.12 1.25E−01 caseonly rs4420312 5.30E−02 caseonly 11/49/99 16/91/117 0.64 0.42 0.97 3.58E−02 caseonly rs7449527 4.61E−02 caseonly 7/53/99 3/57/164 1.71 1.10 2.65 1.72E−02 caseonly rs7839562 3.10E−02 caseonly 29/86/44 46/91/87 1.63 1.05 2.53 3.07E−02 caseonly rs2655222 4.34E−02 caseonly 2/46/111 14/71/139 0.20 0.05 0.91 3.78E−02 caseonly rs2616548 4.98E−02 caseonly 3/35/121 1/40/183 1.37 0.83 2.26 2.18E−01 caseonly rs10497883 3.91E−02 caseonly 4/46/109 8/88/128 0.67 0.46 0.98 4.15E−02 caseonly rs6998016 4.55E−02 caseonly 7/44/108 1/64/159 9.63 1.17 79.34 3.53E−02 caseonly rs11148285 3.92E−02 caseonly 17/76/91 10/124/113 2.30 1.02 5.16 4.42E−02 caseonly rs7305949 1.26E−04 cohort 27/74/58 23/115/86 1.74 0.95 3.17 7.16E−02 caseonly rs264122 7.41E−05 cohort 273/1142/1235 279/1125/1251 0.66 0.46 0.95 2.58E−02 cohort rs1009748 3.95E−03 cohort 400/1202/1054 384/1214/1064 1.35 1.05 1.72 1.81E−02 cohort rs1336400 5.89E−05 cohort 19/67/73 19/87/118 1.35 0.90 2.04 1.53E−01 caseonly rs2108425 1.10E−04 cohort 17/56/83 24/106/92 0.62 0.41 0.94 2.45E−02 caseonly rs2327412 4.19E−03 cohort 30/86/68 31/96/120 1.41 1.07 1.86 1.56E−02 caseonly rs17002013 1.00E−03 cohort 8/70/105 6/71/170 1.66 1.11 2.48 1.28E−02 caseonly rs1015199 7.11E−03 cohort 1/36/147 3/29/215 1.66 0.98 2.78 5.77E−02 caseonly rs7078016 3.59E−04 cohort 19/81/84 23/90/134 1.44 0.98 2.12 6.19E−02 caseonly rs6585412 3.56E−04 cohort 19/81/84 23/90/134 1.44 0.98 2.12 6.19E−02 caseonly rs198476 1.68E−02 cohort 613/1353/665 588/1343/710 1.61 1.06 2.46 2.63E−02 cohort rs2648694 3.71E−03 cohort 28/75/81 18/125/104 2.29 1.22 4.29 9.83E−03 caseonly rs10945874 8.43E−04 cohort 2/42/140 3/45/198 1.24 0.81 1.91 3.19E−01 caseonly rs1190706 5.65E−04 cohort 285/1100/1252 285/1176/1190 0.70 0.50 0.99 4.37E−02 cohort rs3763978 6.03E−03 cohort 417/1255/984 411/1224/1024 0.68 0.53 0.87 2.46E−03 cohort rs11138314 1.34E−02 cohort 34/563/2059 46/555/2057 0.59 0.39 0.89 1.22E−02 cohort rs13107334 8.24E−03 cohort 8/52/124 12/85/150 0.74 0.50 1.11 1.49E−01 caseonly rs6685920 2.93E−04 cohort 7/45/132 5/49/193 1.40 0.90 2.18 1.35E−01 caseonly rs2616552 8.81E−03 cohort 9/52/98 6/68/150 1.32 0.92 1.89 1.37E−01 caseonly rs2110564 6.27E−02 cohort 28/74/82 31/139/77 0.56 0.37 0.83 3.82E−03 caseonly rs10012485 5.90E−02 cohort 10/52/122 12/97/138 0.64 0.43 0.95 2.56E−02 caseonly rs1798093 1.71E−02 cohort 473/1222/957 491/1279/890 1.63 1.03 2.59 3.71E−02 cohort rs4787415 1.72E−02 cohort 29/89/41 69/99/56 0.52 0.31 0.85 8.69E−03 caseonly rs11734256 8.84E−04 cohort 37/100/47 59/111/77 0.81 0.51 1.30 3.88E−01 caseonly rs1266489 1.89E−03 cohort 20/73/91 32/113/102 0.74 0.50 1.09 1.26E−01 caseonly rs238250 8.40E−04 cohort 55/719/1881 68/672/1921 1.43 1.03 1.97 3.13E−02 cohort rs2588350 1.62E−03 cohort 7/63/114 17/102/128 0.68 0.49 0.95 2.31E−02 caseonly rs498657 1.33E−03 cohort 4/55/100 7/63/154 1.18 0.81 1.72 4.00E−01 caseonly rs6427807 1.46E−02 cohort 391/1269/993 439/1236/983 0.67 0.47 0.96 2.85E−02 cohort rs619825 2.29E−02 cohort 20/76/63 43/102/78 0.61 0.34 1.09 9.80E−02 caseonly rs9478241 7.99E−03 cohort 21/76/86 19/108/118 1.54 0.80 2.96 1.97E−01 caseonly rs1727746 1.90E−03 cohort 21/86/76 22/98/127 1.50 1.02 2.20 4.18E−02 caseonly rs2505039 7.20E−04 cohort 486/1334/834 527/1350/786 0.78 0.60 1.02 6.83E−02 cohort rs4472926 4.86E−02 cohort 20/66/73 23/115/86 0.71 0.47 1.08 1.10E−01 caseonly rs6539231 3.59E−03 cohort 40/88/56 52/140/55 0.66 0.43 1.02 5.92E−02 caseonly rs7959965 1.14E−02 cohort 30/82/72 44/137/66 0.75 0.57 1.00 4.97E−02 caseonly rs974950 7.47E−02 cohort 28/74/82 31/139/77 0.56 0.37 0.83 3.82E−03 caseonly rs1524962 4.61E−04 cohort 9/60/90 23/86/115 0.78 0.56 1.08 1.28E−01 caseonly rs17821383 4.37E−03 cohort 3/60/96 13/70/141 0.33 0.09 1.18 8.85E−02 caseonly rs10518335 6.53E−02 cohort 11/52/121 13/96/138 0.65 0.44 0.97 3.35E−02 caseonly rs12265891 5.58E−03 cohort 38/76/45 43/100/79 1.27 0.77 2.09 3.43E−01 caseonly rs4807536 2.01E−03 cohort 3/19/162 1/14/232 2.13 1.07 4.24 3.22E−02 caseonly rs9914580 5.56E−02 cohort 5/36/117 6/72/146 0.67 0.42 1.05 7.85E−02 caseonly rs646749 2.76E−02 cohort 20/75/63 43/101/78 0.62 0.35 1.10 9.97E−02 caseonly rs1003322 4.17E−03 cohort 9/58/92 8/64/152 1.52 0.99 2.32 5.29E−02 caseonly rs4660234 5.46E−04 cohort 53/567/2036 57/576/2031 1.32 0.88 1.97 1.80E−01 cohort rs4038018 8.85E−03 cohort 27/65/67 55/105/64 0.55 0.36 0.85 6.49E−03 caseonly rs7710039 8.96E−03 cohort 7/67/110 18/106/123 0.65 0.44 0.96 3.15E−02 caseonly rs13150189 2.74E−02 cohort 12/70/102 9/67/171 1.83 1.23 2.72 3.06E−03 caseonly rs12646525 5.51E−02 cohort 10/52/122 13/96/138 0.64 0.43 0.95 2.56E−02 caseonly rs2113334 1.18E−02 cohort 6/73/105 15/84/148 0.53 0.20 1.41 2.06E−01 caseonly rs251817 1.59E−02 cohort 0/13/170 0/6/241 2.98 1.11 8.03 3.08E−02 caseonly rs2574 1.77E−02 cohort 57/87/39 56/128/63 1.54 1.00 2.38 5.03E−02 caseonly rs12679254 2.98E−03 cohort 14/76/94 30/117/100 0.65 0.44 0.95 2.77E−02 caseonly rs12341095 4.90E−03 cohort 180/1006/1468 154/1001/1503 2.38 1.14 4.96 2.05E−02 cohort rs17048681 2.34E−02 cohort 44/90/50 34/125/88 1.49 1.13 1.98 5.10E−03 caseonly rs1942876 2.82E−02 cohort 20/75/64 43/102/79 0.62 0.35 1.10 1.02E−01 caseonly rs2657940 5.19E−03 cohort 11/62/86 10/62/152 1.57 1.12 2.21 9.90E−03 caseonly rs494111 3.08E−02 cohort 19/77/62 43/104/77 0.59 0.33 1.06 7.90E−02 caseonly rs2060022 1.54E−03 cohort 45/94/45 79/109/59 0.69 0.45 1.07 9.41E−02 caseonly rs7338174 1.75E−02 cohort 1/10/148 1/7/216 2.01 0.79 5.14 1.44E−01 caseonly rs12048902 2.93E−03 cohort 24/90/70 41/120/86 0.87 0.66 1.16 3.46E−01 caseonly rs6746182 7.63E−03 cohort 6/66/87 9/62/153 1.79 1.17 2.73 6.97E−03 caseonly rs7276749 1.84E−03 cohort 0/10/174 1/18/228 0.68 0.31 1.52 3.50E−01 caseonly rs198460 1.48E−02 cohort 620/1368/663 591/1353/713 1.54 1.01 2.34 4.59E−02 cohort rs7785499 3.74E−02 cohort 59/85/40 56/130/61 1.62 1.05 2.49 2.89E−02 caseonly rs996022 3.27E−02 cohort 20/75/64 43/102/79 0.62 0.35 1.10 1.02E−01 caseonly rs7222186 7.77E−02 cohort 6/36/117 6/72/146 0.68 0.44 1.07 9.51E−02 caseonly rs198464 4.86E−02 cohort 50/69/40 42/122/60 2.04 1.27 3.29 3.35E−03 caseonly rs16934059 7.03E−02 cohort 13/64/82 33/105/86 0.57 0.38 0.87 8.36E−03 caseonly rs1566221 1.10E−02 cohort 0/14/145 0/42/182 0.41 0.21 0.78 6.53E−03 caseonly rs8129810 1.89E−03 cohort 0/10/174 1/18/228 0.68 0.31 1.52 3.50E−01 caseonly rs1344081 1.14E−02 cohort 106/820/1729 101/844/1709 1.58 1.10 2.26 1.25E−02 cohort rs7918692 1.91E−02 cohort 8/43/133 3/41/203 1.76 1.11 2.79 1.59E−02 caseonly rs4686740 3.98E−02 cohort 55/87/42 54/122/71 1.53 0.98 2.37 5.90E−02 caseonly rs12817873 7.13E−03 cohort 20/89/75 41/133/73 0.69 0.52 0.93 1.38E−02 caseonly rs7508 2.27E−02 cohort 15/77/67 20/92/112 1.39 0.92 2.10 1.17E−01 caseonly rs271046 2.30E−03 cohort 19/94/71 40/115/92 0.58 0.32 1.05 6.99E−02 caseonly rs2011318 2.57E−02 cohort 2/23/133 8/47/169 0.60 0.38 0.95 2.83E−02 caseonly rs1136046 8.11E−04 cohort 2/35/147 2/43/202 1.16 0.74 1.83 5.13E−01 caseonly rs1450092 1.89E−03 cohort 4/43/112 8/81/135 0.68 0.46 1.01 5.29E−02 caseonly rs7070244 1.43E−02 cohort 8/39/135 3/38/206 1.72 1.15 2.59 8.56E−03 caseonly rs892162 2.95E−02 cohort 20/80/59 51/100/73 0.47 0.27 0.84 9.96E−03 caseonly rs6563805 8.26E−02 cohort 2/24/133 4/54/166 0.59 0.37 0.94 2.75E−02 caseonly rs9906737 5.44E−02 cohort 6/37/116 6/72/146 0.70 0.45 1.10 1.23E−01 caseonly rs475420 1.75E−03 cohort 0/29/155 0/29/217 1.37 0.78 2.38 2.73E−01 caseonly rs17644708 2.65E−02 cohort 13/78/93 31/116/100 0.52 0.26 1.03 5.89E−02 caseonly rs7067780 3.11E−02 cohort 8/43/132 3/38/206 1.93 1.21 3.07 5.99E−03 caseonly rs4773 3.94E−03 cohort 20/73/91 32/111/104 0.77 0.52 1.13 1.79E−01 caseonly rs6742894 8.45E−02 cohort 49/91/44 47/123/77 1.56 0.98 2.46 5.86E−02 caseonly rs1045916 1.39E−03 cohort 157/975/1521 170/995/1496 0.80 0.58 1.10 1.78E−01 cohort rs6435378 3.05E−02 cohort 34/70/55 42/134/48 0.52 0.33 0.82 4.94E−03 caseonly rs13411119 4.53E−02 cohort 22/84/78 18/87/142 1.83 1.24 2.69 2.34E−03 caseonly rs1531842 5.54E−03 cohort 13/54/92 21/89/114 0.76 0.50 1.15 1.90E−01 caseonly rs9857 1.14E−03 cohort 6/64/114 18/82/147 0.83 0.60 1.15 2.67E−01 caseonly rs9960 3.88E−03 cohort 10/57/117 7/63/177 1.41 0.94 2.13 9.91E−02 caseonly rs13103899 2.39E−02 cohort 5/53/126 8/83/156 0.78 0.52 1.17 2.32E−01 caseonly rs6848512 6.96E−02 cohort 38/90/56 65/133/49 0.55 0.35 0.86 8.50E−03 caseonly rs10181805 3.21E−02 cohort 11/74/99 8/76/163 1.58 1.13 2.21 7.18E−03 caseonly rs1129570 4.41E−02 cohort 7/52/100 5/54/165 1.58 1.08 2.31 1.83E−02 caseonly rs9986576 1.30E−02 cohort 21/75/87 20/108/117 1.46 0.76 2.78 2.54E−01 caseonly rs1352236 6.31E−02 cohort 6/62/91 28/84/112 0.27 0.11 0.66 4.24E−03 caseonly rs7770578 3.13E−02 cohort 0/23/136 6/43/174 0.57 0.34 0.94 2.88E−02 caseonly rs2748901 2.05E−02 cohort 517/1250/885 452/1342/868 1.81 1.11 2.95 1.80E−02 cohort rs1155875 5.63E−02 cohort 21/85/52 61/104/59 0.66 0.49 0.89 6.12E−03 caseonly rs675163 2.23E−02 cohort 2/31/151 4/54/189 0.71 0.46 1.11 1.32E−01 caseonly rs1068705 2.34E−02 cohort 615/1268/767 672/1320/661 0.74 0.49 1.11 1.45E−01 cohort rs1505469 6.03E−02 cohort 2/44/113 1/48/175 1.47 0.94 2.30 9.11E−02 caseonly rs623400 7.39E−02 cohort 16/63/105 25/111/111 0.62 0.42 0.92 1.60E−02 caseonly rs6040760 1.37E−04 cohort 18/72/94 23/87/137 1.23 0.83 1.81 2.98E−01 caseonly rs17310169 6.66E−03 cohort 2/54/128 4/81/162 0.81 0.54 1.23 3.22E−01 caseonly rs7623808 1.50E−02 cohort 6/46/132 2/58/187 4.22 0.83 21.33 8.20E−02 caseonly rs77638540 2.41E−03 cohort 0/10/174 1/18/228 0.68 0.31 1.52 3.50E−01 caseonly rs581401 2.53E−02 cohort 19/76/64 43/103/78 0.59 0.33 1.05 7.35E−02 caseonly rs4251580 8.76E−02 cohort 1/35/148 3/76/168 0.55 0.35 0.85 6.68E−03 caseonly rs603940 2.40E−02 cohort 19/77/63 43/103/78 0.59 0.33 1.05 7.35E−02 caseonly rs13117043 1.23E−01 cohort 5/42/112 3/41/180 1.73 1.07 2.78 2.45E−02 caseonly rs3800202 5.25E−03 cohort 0/9/150 1/23/200 0.49 0.22 1.07 7.33E−02 caseonly rs10738948 7.21E−02 cohort 19/77/63 36/118/70 0.74 0.55 1.02 6.20E−02 caseonly rs623584 2.32E−02 cohort 19/76/64 43/104/77 0.59 0.33 1.05 7.35E−02 caseonly rs9557509 2.28E−03 cohort 44/636/1977 46/585/2031 1.42 0.95 2.11 8.72E−02 cohort rs11668038 3.36E−02 cohort 122/885/1648 111/846/1702 1.25 0.91 1.71 1.62E−01 cohort rs10802865 3.12E−03 cohort 625/1329/702 604/1353/706 1.16 0.90 1.50 2.52E−01 cohort rs17035071 8.90E−03 cohort 114/855/1681 112/836/1709 1.22 0.84 1.77 3.03E−01 cohort rs1439269 3.56E−02 cohort 20/72/67 15/75/134 1.74 1.27 2.39 6.20E−04 caseonly rs208025 7.23E−02 cohort 12/79/93 9/89/149 1.52 1.03 2.23 3.55E−02 caseonly rs12608167 3.67E−02 cohort 7/36/141 8/70/169 0.66 0.42 1.02 5.92E−02 caseonly rs133871 1.64E−01 cohort 20/54/85 25/105/94 0.64 0.42 0.96 3.04E−02 caseonly rs7068975 1.62E−02 cohort 3/32/124 1/26/197 2.02 1.16 3.51 1.24E−02 caseonly rs1866386 3.18E−03 cohort 4/57/123 12/80/155 0.81 0.57 1.14 2.23E−01 caseonly rs1580713 3.16E−02 cohort 45/72/41 41/116/66 1.68 1.03 2.75 3.75E−02 caseonly rs936671 4.56E−02 cohort 11/58/90 25/92/107 0.70 0.46 1.06 8.80E−02 caseonly rs3732136 6.98E−02 cohort 20/71/68 16/74/134 1.99 1.32 3.01 1.13E−03 caseonly rs17718867 6.28E−03 cohort 5/45/109 8/82/134 0.74 0.51 1.08 1.18E−01 caseonly rs5764592 5.39E−02 cohort 6/38/140 2/33/212 1.87 1.14 3.07 1.29E−02 caseonly rs2880563 6.81E−02 cohort 14/84/86 14/92/141 1.51 1.03 2.22 3.69E−02 caseonly rs1564078 3.95E−03 cohort 402/1248/992 447/1288/915 0.79 0.61 1.03 8.02E−02 cohort rs10817479 5.83E−03 cohort 0/32/152 2/31/214 1.37 0.81 2.33 2.42E−01 caseonly rs478859 6.17E−02 cohort 47/101/36 57/112/78 1.33 1.02 1.75 3.89E−02 caseonly rs10106852 1.15E−01 cohort 27/77/80 25/124/98 1.56 0.87 2.79 1.38E−01 caseonly rs12659030 1.21E−02 cohort 17/72/70 12/89/123 1.53 1.01 2.30 4.31E−02 caseonly rs1536506 1.06E−02 cohort 47/79/58 48/127/72 1.43 0.90 2.26 1.29E−01 caseonly rs2184393 7.98E−03 cohort 18/61/80 32/97/95 0.72 0.48 1.08 1.13E−01 caseonly rs11077308 1.75E−01 cohort 4/52/103 2/48/174 1.86 1.18 2.93 7.39E−03 caseonly rs7915250 1.04E−02 cohort 28/71/84 41/104/101 0.81 0.55 1.19 2.83E−01 caseonly rs4689078 3.84E−02 cohort 37/104/43 36/126/85 1.45 1.08 1.93 1.28E−02 caseonly rs2869680 8.13E−02 cohort 4/64/116 15/97/135 0.70 0.50 0.98 3.59E−02 caseonly rs12286877 3.26E−02 cohort 0/13/171 1/7/239 2.30 0.93 5.69 7.06E−02 caseonly rs10460737 2.98E−02 cohort 0/1/183 0/13/234 0.10 0.01 0.75 2.54E−02 caseonly PROVEIT OR OR End- Marker Atorv Count Prav Count OR L95 U95 P value Source Model point rs13129010 6/47/138 5/51/196 1.39 0.89 2.16 1.44E−01 caseonly dom CHD rs4242281 37/78/76 27/127/98 2.08 1.20 3.60 8.70E−03 caseonly rec CVD rs6474228 9/87/95 19/90/143 1.32 0.90 1.93 1.52E−01 caseonly dom CHD rs4240808 28/97/66 59/123/70 0.56 0.34 0.92 2.26E−02 caseonly rec CVD rs13126170 6/37/148 7/81/164 0.53 0.34 0.82 4.23E−03 caseonly dom CVD rs7916629 21/82/86 15/101/136 2.11 1.05 4.26 3.73E−02 caseonly rec CVD rs11721179 14/41/136 12/80/160 0.64 0.41 0.99 4.53E−02 caseonly dom CVD rs2993156 11/57/123 23/84/145 0.75 0.50 1.10 1.42E−01 caseonly dom CVD rs10774580 26/85/80 40/132/80 0.63 0.43 0.94 2.27E−02 caseonly dom CHD rs16885715 10/60/121 9/67/176 1.34 0.89 2.00 1.59E−01 caseonly dom CHD rs4870109 37/78/76 28/124/98 1.97 1.14 3.40 1.48E−02 caseonly rec CVD rs17688430 4/51/136 10/77/165 0.77 0.54 1.11 1.57E−01 caseonly add CVD rs7332076 23/69/99 14/100/138 2.40 1.18 4.88 1.62E−02 caseonly rec CVD rs694780 19/106/66 50/108/94 0.40 0.21 0.73 3.11E−03 caseonly rec CHD rs4836745 13/76/102 25/119/108 0.65 0.44 0.96 2.82E−02 caseonly dom CVD rs7018577 15/79/97 18/83/151 1.44 0.98 2.12 6.13E−02 caseonly dom CHD rs11585647 10/26/155 14/61/177 0.49 0.30 0.80 4.76E−03 caseonly dom CVD rs4420312 8/56/127 10/106/136 0.59 0.40 0.87 8.31E−03 caseonly dom CHD rs7449527 8/61/122 8/60/184 1.53 1.01 2.30 4.28E−02 caseonly dom CHD rs7839562 47/95/49 39/125/88 1.54 1.01 2.34 4.35E−02 caseonly dom CHD rs2655222 3/80/108 17/71/164 0.23 0.07 0.80 2.09E−02 caseonly rec CHD rs2616548 8/57/126 2/52/198 2.02 1.28 3.16 2.29E−03 caseonly dom CHD rs10497883 3/57/131 13/88/151 0.68 0.48 0.96 2.91E−02 caseonly add CHD rs6998016 9/61/121 2/73/177 6.19 1.27 30.09 2.39E−02 caseonly rec CHD rs11148285 27/72/92 22/101/129 1.87 1.01 3.48 4.67E−02 caseonly rec CVD rs7305949 130/459/419 133/443/434 2.34 1.29 4.22 4.97E−03 cohort rec CHD rs264122 144/421/454 136/459/419 0.72 0.50 1.05 8.92E−02 cohort dom CHD rs1009748 121/455/444 118/435/460 1.43 1.09 1.88 1.06E−02 cohort add CVD rs1336400 151/404/459 116/431/465 1.46 1.00 2.12 4.82E−02 cohort dom CHD rs2108425 148/415/447 138/469/405 0.77 0.53 1.12 1.69E−01 cohort dom CHD rs2327412 122/453/443 119/431/463 1.38 1.05 1.81 2.08E−02 cohort add CVD rs17002013 54/346/616 57/351/604 1.38 0.94 2.02 9.55E−02 cohort dom CVD rs1015199 19/226/775 11/200/803 1.93 1.23 3.03 4.06E−03 cohort dom CVD rs7078016 140/415/466 112/439/466 1.41 0.97 2.04 7.29E−02 cohort dom CVD rs6585412 144/404/469 116/433/465 1.39 0.96 2.02 8.12E−02 cohort dom CVD rs198476 65/85/41 55/132/65 1.85 1.21 2.84 4.85E−03 caseonly rec CHD rs2648694 108/459/453 113/452/451 1.72 0.95 3.11 7.49E−02 cohort rec CVD rs10945874 22/196/799 20/201/795 1.72 1.15 2.58 8.16E−03 cohort add CVD rs1190706 103/476/441 129/443/445 0.76 0.52 1.10 1.42E−01 cohort dom CVD rs3763978 154/448/418 171/478/365 0.84 0.65 1.10 2.06E−01 cohort add CVD rs11138314 22/228/765 19/256/740 0.64 0.43 0.95 2.83E−02 cohort add CHD rs13107334 46/286/687 37/293/683 0.53 0.35 0.80 2.36E−03 cohort dom CVD rs6685920 28/243/750 19/227/771 1.45 0.93 2.25 9.96E−02 cohort dom CVD rs2616552 86/353/581 73/362/581 1.55 1.15 2.08 3.98E−03 cohort add CHD rs2110564 182/476/360 204/470/341 0.60 0.40 0.89 1.17E−02 cohort dom CVD rs10012485 61/341/619 47/357/613 0.54 0.36 0.79 1.78E−03 cohort dom CVD rs1798093 187/469/364 160/456/396 2.00 1.17 3.42 1.13E−02 cohort rec CHD rs4787415 33/101/57 64/118/70 0.62 0.38 0.99 4.76E−02 caseonly rec CHD rs11734256 219/511/278 226/491/287 0.57 0.36 0.89 1.46E−02 cohort rec CVD rs1266489 169/473/368 180/468/364 0.67 0.45 0.98 4.00E−02 cohort dom CVD rs238250 22/239/759 22/241/752 1.24 0.86 1.80 2.50E−01 cohort add CVD rs2588350 52/340/616 41/363/606 0.82 0.59 1.13 2.30E−01 cohort add CVD rs498657 8/66/117 4/69/179 1.57 1.10 2.24 1.40E−02 caseonly add CHD rs6427807 157/456/393 179/464/369 0.66 0.45 0.97 3.26E−02 cohort dom CVD rs619825 19/107/65 50/109/93 0.40 0.21 0.73 3.11E−03 caseonly rec CHD rs9478241 37/78/76 27/127/98 2.08 1.20 3.60 8.70E−03 caseonly rec CVD rs1727746 154/450/409 120/441/449 1.30 0.89 1.90 1.68E−01 cohort dom CVD rs2505039 252/494/269 254/499/258 0.84 0.65 1.09 1.97E−01 cohort add CHD rs4472926 22/63/106 29/123/100 0.53 0.36 0.78 1.17E−03 caseonly dom CHD rs6539231 51/80/60 60/131/61 0.68 0.45 1.05 7.89E−02 caseonly dom CVD rs7959965 34/92/65 67/115/70 0.74 0.57 0.97 2.87E−02 caseonly add CVD rs974950 179/455/376 201/455/352 0.64 0.43 0.94 2.37E−02 cohort dom CVD rs1524962 11/64/116 15/105/132 0.80 0.58 1.10 1.70E−01 caseonly add CHD rs17821383 5/70/116 18/89/145 0.35 0.13 0.96 4.18E−02 caseonly rec CHD rs10518335 9/47/135 9/99/143 0.55 0.37 0.82 3.26E−03 caseonly dom CVD rs12265891 53/82/56 39/127/85 2.13 1.33 3.41 1.78E−03 caseonly rec CHD rs4807536 1/16/174 1/14/237 1.53 0.74 3.16 2.50E−01 caseonly dom CVD rs9914580 3/41/147 10/82/160 0.51 0.33 0.78 2.05E−03 caseonly dom CHD rs646749 19/106/66 50/108/94 0.40 0.21 0.73 3.11E−03 caseonly rec CHD rs1003322 11/70/110 5/82/165 1.41 0.95 2.08 8.60E−02 caseonly dom CHD rs4660234 28/238/750 20/222/774 1.45 0.93 2.25 9.97E−02 cohort dom CHD rs4038018 44/88/59 68/119/65 0.76 0.50 1.17 2.11E−01 caseonly dom CHD rs7710039 11/63/117 17/102/133 0.70 0.48 1.03 7.21E−02 caseonly dom CVD rs13150189 7/70/114 18/65/169 1.36 0.92 2.02 1.22E−01 caseonly dom CVD rs12646525 65/338/616 46/360/605 0.59 0.40 0.87 7.91E−03 cohort dom CVD rs2113334 7/73/111 27/92/133 0.29 0.12 0.70 6.07E−03 caseonly rec CVD rs251817 1/22/168 0/17/235 2.02 1.06 3.86 3.35E−02 caseonly add CVD rs2574 258/474/287 237/537/242 1.62 1.07 2.44 2.30E−02 cohort rec CVD rs12679254 19/77/95 26/115/111 0.79 0.53 1.16 2.21E−01 caseonly dom CVD rs12341095 79/404/536 64/384/565 1.63 0.82 3.24 1.68E−01 cohort rec CHD rs17048681 30/91/70 30/114/108 1.25 0.95 1.66 1.15E−01 caseonly add CVD rs1942876 18/108/65 48/108/96 0.41 0.23 0.76 4.18E−03 caseonly rec CHD rs2657940 7/75/109 12/80/160 1.20 0.86 1.67 2.77E−01 caseonly add CHD rs494111 19/107/65 49/109/94 0.44 0.25 0.79 5.96E−03 caseonly rec CHD rs2060022 42/81/68 72/101/79 0.72 0.46 1.12 1.40E−01 caseonly rec CVD rs7338174 1/24/166 1/14/237 2.50 1.25 4.99 9.45E−03 caseonly dom CHD rs12048902 20/77/94 53/90/109 0.72 0.55 0.94 1.73E−02 caseonly add CVD rs6746182 73/376/568 65/375/576 1.25 0.86 1.81 2.38E−01 cohort dom CHD rs7276749 4/84/931 4/108/904 0.45 0.22 0.90 2.45E−02 cohort dom CVD rs198460 273/496/244 243/509/253 1.55 1.02 2.36 3.93E−02 cohort rec CHD rs7785499 258/486/267 214/516/281 1.68 1.09 2.61 1.97E−02 cohort rec CVD rs996022 18/108/65 48/108/96 0.41 0.23 0.76 4.18E−03 caseonly rec CHD rs7222186 2/40/148 9/82/161 0.50 0.32 0.77 1.48E−03 caseonly dom CHD rs198464 291/482/231 263/493/248 1.44 0.96 2.17 7.90E−02 cohort rec CHD rs16934059 119/460/439 121/463/430 0.65 0.45 0.95 2.65E−02 cohort dom CHD rs1566221 4/99/917 3/125/887 0.68 0.37 1.26 2.22E−01 cohort add CHD rs8129810 3/84/933 5/107/902 0.45 0.22 0.91 2.69E−02 cohort dom CVD rs1344081 8/61/122 8/68/176 1.31 0.88 1.96 1.86E−01 caseonly dom CVD rs7918692 0/52/139 3/48/201 1.48 0.95 2.32 8.37E−02 caseonly dom CVD rs4686740 53/85/53 45/141/66 1.86 1.17 2.97 8.84E−03 caseonly rec CVD rs12817873 165/458/398 179/482/355 0.85 0.65 1.10 2.15E−01 cohort add CVD rs7508 10/91/90 15/87/150 1.65 1.13 2.43 1.03E−02 caseonly dom CHD rs271046 29/89/73 50/103/99 0.68 0.40 1.18 1.74E−01 caseonly rec CVD rs2011318 1/34/156 3/64/185 0.63 0.40 0.99 4.35E−02 caseonly add CHD rs1136046 5/47/139 2/50/200 1.48 0.98 2.22 6.15E−02 caseonly add CVD rs1450092 6/51/134 10/79/163 0.81 0.57 1.15 2.41E−01 caseonly add CHD rs7070244 3/56/132 5/56/191 1.30 0.87 1.94 2.06E−01 caseonly add CVD rs892162 29/99/63 54/127/71 0.64 0.39 1.06 8.48E−02 caseonly rec CHD rs6563805 3/29/159 8/66/178 0.53 0.35 0.80 2.73E−03 caseonly add CHD rs9906737 2/43/146 9/83/160 0.53 0.35 0.81 3.19E−03 caseonly dom CHD rs475420 2/38/151 1/36/215 1.57 0.95 2.59 7.80E−02 caseonly dom CVD rs17644708 7/101/83 25/122/105 0.34 0.14 0.81 1.45E−02 caseonly rec CVD rs7067780 3/53/135 7/50/195 1.41 0.91 2.18 1.24E−01 caseonly dom CVD rs4773 28/86/77 52/120/80 0.68 0.45 1.01 5.68E−02 caseonly dom CVD rs6742894 60/81/50 50/138/64 1.94 1.24 3.03 3.53E−03 caseonly rec CVD rs1045916 15/61/115 20/103/129 0.79 0.58 1.07 1.29E−01 caseonly add CHD rs6435378 33/84/74 46/125/81 0.74 0.50 1.10 1.40E−01 caseonly dom CHD rs13411119 23/82/86 24/98/130 1.32 0.89 1.94 1.69E−01 caseonly dom CVD rs1531842 17/74/100 21/123/108 0.67 0.46 0.98 4.15E−02 caseonly dom CHD rs9857 12/63/116 15/108/129 0.78 0.57 1.07 1.18E−01 caseonly add CVD rs9960 11/57/123 8/64/180 1.37 0.92 2.06 1.25E−01 caseonly dom CVD rs13103899 6/37/148 7/82/163 0.53 0.34 0.81 3.72E−03 caseonly dom CVD rs6848512 48/84/59 65/131/56 0.64 0.41 0.98 4.02E−02 caseonly dom CVD rs10181805 16/60/115 10/79/163 1.28 0.93 1.75 1.27E−01 caseonly add CVD rs1129570 10/65/116 6/73/173 1.41 1.00 1.98 4.80E−02 caseonly add CHD rs9986576 36/79/76 27/126/98 2.00 1.15 3.47 1.36E−02 caseonly rec CVD rs1352236 10/84/97 30/93/129 0.39 0.18 0.84 1.60E−02 caseonly rec CHD rs7770578 3/35/153 6/66/180 0.65 0.43 0.99 4.58E−02 caseonly add CHD rs2748901 226/504/290 196/502/318 1.43 0.92 2.23 1.14E−01 cohort rec CHD rs1155875 32/84/75 58/111/83 0.79 0.61 1.03 7.69E−02 caseonly add CHD rs675163 1/33/157 5/64/183 0.58 0.38 0.90 1.44E−02 caseonly add CVD rs1068705 44/84/63 55/141/56 0.58 0.38 0.89 1.23E−02 caseonly dom CHD rs1505469 5/44/142 2/36/213 1.85 1.20 2.85 5.58E−03 caseonly add CHD rs623400 20/55/116 25/100/127 0.65 0.44 0.96 3.00E−02 caseonly dom CVD rs6040760 21/70/99 18/84/150 1.34 0.91 1.97 1.35E−01 caseonly dom CVD rs17310169 4/43/143 9/79/164 0.61 0.40 0.92 2.01E−02 caseonly dom CVD rs7623808 7/37/147 2/55/195 4.79 0.98 23.38 5.28E−02 caseonly rec CVD rs77638540 6/76/935 4/106/906 0.49 0.24 1.00 5.04E−02 cohort dom CVD rs581401 137/494/385 185/471/359 0.54 0.31 0.95 3.34E−02 cohort rec CHD rs4251580 4/28/159 4/63/185 0.64 0.42 0.98 4.06E−02 caseonly add CVD rs603940 136/503/380 182/481/354 0.55 0.31 0.96 3.64E−02 cohort rec CHD rs13117043 6/61/124 5/55/192 1.74 1.15 2.64 9.53E−03 caseonly dom CHD rs3800202 2/67/937 1/77/922 0.59 0.29 1.20 1.43E−01 cohort add CHD rs10738948 14/99/78 43/120/88 0.68 0.51 0.91 9.76E−03 caseonly add CHD rs623584 141/482/390 186/460/360 0.56 0.33 0.98 4.18E−02 cohort rec CHD rs9557509 8/47/136 5/55/192 1.29 0.83 2.00 2.62E−01 caseonly dom CHD rs11668038 16/82/93 15/83/154 1.54 1.11 2.12 8.96E−03 caseonly add CHD rs10802865 57/88/46 49/137/66 1.29 0.98 1.69 6.73E−02 caseonly add CHD rs17035071 10/73/108 8/73/171 1.60 1.07 2.37 2.06E−02 caseonly dom CHD rs1439269 21/83/87 22/97/133 1.27 0.94 1.72 1.25E−01 caseonly add CHD rs208025 8/80/102 11/78/162 1.55 1.05 2.29 2.60E−02 caseonly dom CVD rs12608167 23/209/785 21/253/740 0.63 0.40 0.98 4.24E−02 cohort dom CVD rs133871 19/73/99 27/124/101 0.59 0.40 0.87 8.11E−03 caseonly dom CHD rs7068975 0/33/158 1/34/216 1.32 0.78 2.22 3.05E−01 caseonly dom CHD rs1866386 6/61/124 12/93/147 0.77 0.55 1.08 1.32E−01 caseonly add CVD rs1580713 39/103/49 37/138/77 1.55 0.94 2.56 8.88E−02 caseonly rec CHD rs936671 14/60/117 21/102/129 0.64 0.44 0.95 2.62E−02 caseonly dom CHD rs3732136 22/84/85 25/94/133 1.42 0.96 2.09 8.12E−02 caseonly dom CHD rs17718867 5/51/135 10/79/163 0.77 0.54 1.10 1.57E−01 caseonly add CHD rs5764592 3/44/144 6/41/205 1.48 0.91 2.42 1.15E−01 caseonly dom CVD rs2880563 15/85/90 23/86/143 1.51 1.02 2.24 3.78E−02 caseonly dom CVD rs1564078 29/98/64 53/115/84 0.86 0.66 1.14 2.98E−01 caseonly add CHD rs10817479 2/23/166 0/20/232 1.77 0.95 3.31 7.42E−02 caseonly dom CVD rs478859 49/92/50 59/99/94 1.32 1.01 1.73 4.14E−02 caseonly add CVD rs10106852 40/78/73 28/118/106 2.19 1.29 3.71 3.79E−03 caseonly rec CVD rs12659030 10/82/99 16/92/144 1.27 0.86 1.86 2.24E−01 caseonly dom CHD rs1536506 56/80/55 56/132/64 1.44 0.93 2.23 1.05E−01 caseonly rec CVD rs2184393 30/78/83 44/116/92 0.75 0.51 1.11 1.51E−01 caseonly dom CHD rs11077308 1/63/127 4/58/190 1.55 1.02 2.36 3.98E−02 caseonly dom CHD rs7915250 33/78/80 41/128/83 0.66 0.44 0.99 4.43E−02 caseonly dom CVD rs4689078 39/98/54 44/123/85 1.20 0.91 1.57 2.00E−01 caseonly add CVD rs2869680 7/72/112 21/103/128 0.72 0.52 0.99 4.22E−02 caseonly add CVD rs12286877 1/18/172 1/13/236 2.05 0.92 4.57 8.07E−02 caseonly dom CVD rs10460737 0/1/190 1/11/240 0.10 0.01 0.85 3.53E−02 caseonly add CVD

TABLE 7 allele allele Meta-analysis A1 A2 P value CARE WOSCOPS Marker (non-ref) (ref) OR OR L95 OR U95 (random) Prava Count Placebo Count OR OR L95 OR U95 P value Source Prava Count Placebo Count rs1336400 A G 1.56 1.28 1.89 7.06E−06 306/1284/1371 152/631/686 1.68 1.27 2.22 2.79E−04 cohort rs10787944 G A  32/172/152  40/162/240 1.63 1.22 2.17 8.59E−04 Caseonly  19/81/82  22/91/132 rs13103899 G A 0.67 0.54 0.83 2.51E−04  81/850/1955  39/434/961 0.70 0.52 0.95 2.39E−02 cohort rs13121569 G A  6/91/260  13/147/284 0.66 0.49 0.89 7.50E−03 Caseonly  5/53/126  8/83/156 rs6563805 A G 0.64 0.50 0.82 4.51E−04  42/350/1102  35/383/1052 0.76 0.56 1.04 8.26E−02 cohort rs1324012 A G  5/68/227  9/105/268 0.78 0.57 1.06 1.15E−01 Caseonly  2/26/129  4/57/163 rs17048681 G T 1.30 1.13 1.50 2.15E−04 239/709/546 219/690/562 1.26 1.03 1.54 2.34E−02 cohort rs1559557 G A  55/182/120  51/200/193 1.34 1.09 1.65 6.39E−03 Caseonly  48/85/51  33/127/87 rs7132840 T G 0.74 0.65 0.86 3.61E−05 341/693/418 312/761/361 0.75 0.61 0.91 4.20E−03 cohort rs1877527 G A  59/177/121  92/238/114 0.75 0.61 0.93 7.37E−03 Caseonly  32/83/69  46/137/64 rs12635482 C A 0.61 0.45 0.81 7.53E−04 235/712/548 275/738/458 0.54 0.34 0.86 8.70E−03 cohort rs1917527 A C  22/152/126  70/194/118 0.34 0.21 0.57 4.02E−05 Caseonly  27/74/58  50/99/75 rs198476 G A 1.69 1.34 2.13 1.17E−05 340/768/384 326/759/385 1.58 1.09 2.30 1.68E−02 cohort 613/1353/665 588/1343/710 rs198462 G A  74/153/73  67/214/101 1.57 1.08 2.28 1.90E−02 Caseonly  50/69/40  41/122/61 rs11178579 T G 0.77 0.67 0.89 2.86E−04 259/693/542 245/735/490 0.76 0.63 0.93 8.77E−03 cohort rs2132241 A G  51/153/153  74/228/142 0.74 0.60 0.90 3.60E−03 Caseonly  20/89/75  41/132/74 rs3844207 G C 0.75 0.65 0.86 4.20E−05 321/694/479 295/766/409 0.73 0.60 0.89 2.08E−03 cohort rs2270588 G A  59/165/133  93/235/116 0.72 0.59 0.88 1.46E−03 Caseonly  28/87/69  45/136/66 rs304597 A G 2.70 1.54 4.73 5.08E−04  61/409/980  48/448/938 1.95 0.89 4.29 9.56E−02 cohort rs304601 A G  18/101/238  10/144/290 2.28 1.03 5.03 4.10E−02 Caseonly  10/55/119  4/75/168 rs12553453 C A 1.32 1.12 1.56 7.32E−04 314/693/445 292/668/473 1.22 0.98 1.50 7.15E−02 cohort rs471579 A C  70/142/88  72/174/136 1.26 1.02 1.56 3.39E−02 Caseonly  32/82/45  27/103/94 rs2768652 C T 1.33 1.14 1.54 1.76E−04 261/675/514 241/665/527 1.22 0.98 1.51 7.06E−02 cohort rs7873371 A G  70/143/87  73/175/134 1.25 1.01 1.55 4.05E−02 Caseonly  32/82/45  28/103/93 rs11178579 T G 0.77 0.67 0.88 2.30E−04 259/693/542 245/735/490 0.76 0.63 0.93 8.77E−03 cohort rs9325191 A C  51/154/152  74/228/142 0.74 0.60 0.91 4.36E−03 Caseonly  20/89/75  41/134/72 rs10945874 T C 1.59 1.28 1.97 2.76E−05  19/277/1197  23/270/1178 1.72 1.25 2.36 8.43E−04 cohort rs9346951 A G  7/76/274  4/67/373 1.56 1.12 2.15 7.68E−03 Caseonly  2/42/140  3/45/199 rs13107334 G T 0.69 0.58 0.83 5.80E−05 104/895/1967  52/452/967 0.69 0.53 0.89 4.84E−03 cohort rs988146 G A  6/88/263  13/146/285 0.66 0.50 0.87 3.02E−03 Caseonly  5/53/126  9/82/156 WOSCOPS PROVEIT End- Marker OR OR L95 OR U95 P value Source Atorv Count Prav Count OR OR L95 OR U95 P value Source Model point rs1336400 151/404/459 116/431/465 1.46 1.00 2.12 4.82E−02 cohort dom CVD rs10787944 1.45 0.99 2.14 5.84E−02 Caseonly  29/84/77  29/101/122 1.37 0.93 2.01 1.15E−01 Caseonly dom CVD rs13103899 dom CVD rs13121569 0.78 0.52 1.17 2.32E−01 Caseonly  6/38/147  7/84/161 0.52 0.34 0.80 3.10E−03 Caseonly dom CVD rs6563805 add CHD rs1324012 0.60 0.38 0.96 3.12E−02 Caseonly  3/30/158  10/68/174 0.51 0.34 0.76 1.08E−03 Caseonly add CHD rs17048681 add CVD rs1559557 1.53 1.16 2.02 2.89E−03 Caseonly  32/83/76  30/114/108 1.19 0.90 1.56 2.26E−01 Caseonly add CVD rs7132840 add CVD rs1877527 0.77 0.58 1.02 6.90E−02 Caseonly  31/93/67  64/117/71 0.72 0.55 0.94 1.70E−02 Caseonly add CVD rs12635482 rec CHD rs1917527 0.73 0.44 1.24 2.46E−01 Caseonly  22/98/70  48/117/87 0.57 0.33 1.00 4.86E−02 Caseonly rec CHD rs198476 1.61 1.06 2.46 2.63E−02 cohort rec CHD rs198462 2.12 1.31 3.42 2.23E−03 Caseonly  67/83/41  55/132/65 1.92 1.26 2.94 2.58E−03 Caseonly rec CHD rs11178579 162/444/403 177/462/365 0.85 0.65 1.10 2.20E−01 cohort add CVD rs2132241 0.70 0.52 0.94 1.66E−02 Caseonly  26/87/78  45/121/86 0.79 0.60 1.04 9.47E−02 Caseonly add CVD rs3844207 190/491/336 235/471/306 0.78 0.60 1.01 5.47E−02 cohort add CVD rs2270588 0.75 0.57 1.00 5.34E−02 Caseonly  30/93/68  62/122/68 0.70 0.53 0.92 1.07E−02 Caseonly add CVD rs304597 rec CVD rs304601 3.93 1.20 12.87 2.38E−02 Caseonly  13/52/126  6/70/176 3.63 1.24 10.64 1.88E−02 Caseonly rec CVD rs12553453 add CHD rs471579 1.62 1.20 2.19 1.84E−03 Caseonly  48/80/63  35/132/85 1.27 0.97 1.66 8.39E−02 Caseonly add CHD rs2768652 add CHD rs7873371 1.59 1.17 2.15 2.68E−03 Caseonly  47/82/62  35/129/88 1.31 1.00 1.71 5.23E−02 Caseonly add CHD rs11178579 162/444/403 177/462/365 0.85 0.65 1.10 2.20E−01 cohort add CVD rs9325191 0.69 0.51 0.92 1.19E−02 Caseonly  26/86/79  45/121/86 0.78 0.59 1.03 7.96E−02 Caseonly add CVD rs10945874  22/196/799  20/201/795 1.72 1.15 2.58 8.16E−03 cohort add CVD rs9346951 1.25 0.81 1.92 3.09E−01 Caseonly  5/45/141  0/43/209 1.88 1.22 2.91 4.63E−03 Caseonly add CVD rs13107334  46/286/687  37/293/683 0.60 0.43 0.86 4.97E−03 cohort add CVD rs988146 0.80 0.56 1.14 2.15E−01 Caseonly  6/37/148  7/80/165 0.64 0.44 0.93 2.04E−02 Caseonly add CVD

TABLE 8 Original SNP Genotyped SNP (rs #) (rs #) LD (r{circumflex over ( )}2) rs10193722 rs11124322 1 rs1051334 rs1051344 0.9637 rs10740308 rs2030057 0.9457 rs10831415 rs10831416 1 rs1229430 rs4657668 0.9445 rs12914132 rs6497117 0.9642 rs1594887 rs1529806 1 rs16861476 rs3732788 1 rs1737478 rs1773549 1 rs2196180 rs1560901 1 rs231358 rs231355 0.9636 rs2335451 rs10875941 1 rs2358931 rs9834251 0.8864 rs2593270 rs4765531 1 rs2656824 rs4765531 1 rs302296 rs302290 1 rs3793048 rs3806005 1 rs3861810 rs1560901 1 rs4128766 rs7179134 0.951 rs4242084 rs2148575 1 rs4328731 rs5756670 1 rs4980176 rs7094941 1 rs6550706 rs1851830 1 rs6950121 rs10275879 1 rs7751843 rs7765440 1 rs7901888 rs2030057 1 rs7913568 rs3998860 0.9736 rs9467561 rs6931627 1 rs9554735 rs912366 0.9646 rs10787944 rs1336400 1 rs13121569 rs13103899 1 rs1324012 rs6563805 1 rs1559557 rs17048681 0.8814 rs1877527 rs7132840 0.9591 rs1917527 rs12635482 0.9293 rs198462 rs198476 0.9823 rs2132241 rs11178579 1 rs2270588 rs3844207 1 rs304601 rs304597 0.9732 rs471579 rs12553453 0.931 rs7873371 rs2768652 0.8956 rs9325191 rs11178579 1 rs9346951 rs10945874 0.9567 rs988146 rs13107334 0.9491

TABLE 9 ALLELE SNP rs # SOURCE (A1) MODEL NMISS OR SE L95 U95 STAT P HW_PVALUE ALLELE_FREQ PRAVA_ALLELE_FREQ PLACEBO_ALLELE_FREQ rs198460 Genotyped G REC 682 1.552 0.1926 1.064 2.264 2.284 0.02238 0.02592 0.47507 0.50167 0.4542 rs603940 Genotyped G REC 682 0.614 0.2233 0.3962 0.9509 −2.185 0.02885 0.812 0.40469 0.38833 0.4175 rs10021016 Genotyped G GEN 682 7.495 0.02358 0.8438 0.26393 0.29667 0.2382 rs1003148 Imputed C ADD 674 0.691 0.1112 0.5556 0.8592 −3.325 0.000885 0.04475 0.40059 0.34783 0.4427 rs1003148 Imputed C GEN 674 11.71 0.002865 0.04475 0.40059 0.34783 0.4427 rs1003148 Imputed C REC 674 0.511 0.2158 0.3345 0.7794 −3.115 0.001839 0.04475 0.40059 0.34783 0.4427 rs10046799 Imputed C ADD 671 0.784 0.1099 0.6321 0.9726 −2.212 0.02694 0.1595 0.55365 0.52055 0.5792 rs10046799 Imputed C GEN 671 4.972 0.08326 0.1595 0.55365 0.52055 0.5792 rs10051148 Imputed C DOM 681 0.561 0.1597 0.4104 0.7675 −3.617 0.000298 0.9326 0.34728 0.30833 0.378 rs10054055 Imputed T DOM 681 0.561 0.1597 0.4104 0.7675 −3.617 0.000298 0.9326 0.34728 0.30833 0.378 rs10067895 Imputed A DOM 672 0.561 0.1605 0.4097 0.7686 −3.6 0.000319 0.9321 0.34598 0.3064 0.3773 rs1008705 Imputed C DOM 505 1.49 0.1837 1.04 2.136 2.172 0.02985 0.9137 0.28812 0.3211 0.2631 rs10105871 Imputed C DOM 592 1.731 0.1743 1.23 2.436 3.149 0.001636 0.2592 0.38429 0.42278 0.3544 rs10116807 Imputed A GEN 652 8.336 0.01548 1 0.22469 0.25087 0.2041 rs10116807 Imputed A REC 652 3.065 0.389 1.43 6.569 2.88 0.003983 1 0.22469 0.25087 0.2041 rs10121941 Imputed C DOM 682 0.529 0.2074 0.352 0.7937 −3.074 0.00211 0.6748 0.10191 0.07333 0.1243 rs10128638 Genotyped G DOM 682 0.575 0.1787 0.4054 0.8167 −3.094 0.001978 0.9389 0.49047 0.45167 0.5209 rs1012924 Imputed G ADD 682 0.518 0.1922 0.3551 0.7544 −3.426 0.000612 0.3055 0.10484 0.07167 0.1309 rs1012924 Imputed G DOM 682 0.474 0.2097 0.3145 0.7155 −3.556 0.000376 0.3055 0.10484 0.07167 0.1309 rs1016030 Genotyped G ADD 680 1.4 0.1137 1.12 1.749 2.956 0.00312 0.6897 0.40074 0.44482 0.3661 rs1016030 Genotyped G GEN 680 8.902 0.01167 0.6897 0.40074 0.44482 0.3661 rs1017558 Imputed A REC 668 1.905 0.2304 1.213 2.992 2.798 0.005138 0.4004 0.35853 0.36735 0.3516 rs10183431 Imputed T DOM 677 1.604 0.1584 1.176 2.188 2.983 0.002854 0.06064 0.24372 0.27534 0.2192 rs10195401 Imputed C DOM 671 1.633 0.1636 1.185 2.251 2.998 0.002721 0.9348 0.38227 0.41723 0.3547 rs10239416 Imputed A DOM 658 0.618 0.1624 0.4496 0.8497 −2.963 0.003046 0.8667 0.36702 0.32653 0.3997 rs1032188 Imputed G GEN 682 6.08 0.04784 1 0.30352 0.27167 0.3285 rs1032188 Imputed G REC 682 0.55 0.2837 0.3157 0.9599 −2.104 0.03536 1 0.30352 0.27167 0.3285 rs10468988 Imputed G ADD 679 1.579 0.1261 1.233 2.022 3.624 0.00029 0.6914 0.26068 0.30936 0.2224 rs10478919 Imputed G DOM 681 0.551 0.1595 0.4029 0.753 −3.738 0.000186 1 0.34802 0.30667 0.3806 rs10506623 Imputed C DOM 682 0.591 0.1642 0.4287 0.8159 −3.199 0.001378 0.8737 0.40176 0.36667 0.4293 rs10506626 Imputed A DOM 682 0.565 0.1629 0.4107 0.7779 −3.501 0.000463 0.9364 0.40029 0.36667 0.4267 rs10509477 Imputed T DOM 682 1.772 0.1576 1.301 2.413 3.63 0.000284 1 0.29692 0.335 0.267 rs10511071 Imputed C DOM 682 1.705 0.2034 1.144 2.541 2.623 0.008711 0.3705 0.09457 0.11333 0.0798 rs10511072 Imputed G DOM 682 1.705 0.2034 1.144 2.541 2.623 0.008711 0.3705 0.09457 0.11333 0.0798 rs10511199 Imputed C ADD 679 1.5 0.1343 1.153 1.952 3.019 0.00254 1 0.21944 0.25671 0.1903 rs10513283 Imputed G GEN 680 13.78 0.001017 0.06901 0.19706 0.2408 0.1627 rs10520072 Imputed T DOM 681 0.561 0.1597 0.4104 0.7675 −3.617 0.000298 0.9326 0.34728 0.30833 0.378 rs1065639 Imputed C DOM 645 1.663 0.1678 1.197 2.311 3.031 0.002438 0.3536 0.37132 0.40071 0.3485 rs10733846 Imputed G ADD 676 0.554 0.146 0.4165 0.7381 −4.04 5.35E−05 0.02372 0.19009 0.1388 0.2308 rs10733846 Imputed G DOM 676 0.557 0.1721 0.3978 0.7808 −3.398 0.000679 0.02372 0.19009 0.1388 0.2308 rs10737390 Imputed T DOM 678 0.561 0.161 0.4094 0.7694 −3.588 0.000333 0.4645 0.38274 0.33833 0.418 rs10749293 Imputed G DOM 682 1.794 0.1572 1.319 2.442 3.72 0.000199 1 0.29252 0.33167 0.2618 rs10752159 Imputed G DOM 676 1.431 0.1604 1.045 1.96 2.234 0.02545 1 0.21598 0.24329 0.1944 rs10753760 Imputed T ADD 650 1.411 0.1167 1.122 1.773 2.949 0.003192 0.6867 0.41692 0.46466 0.3801 rs10753760 Imputed T GEN 650 9.074 0.01071 0.6867 0.41692 0.46466 0.3801 rs10757887 Imputed C DOM 677 0.616 0.1602 0.4502 0.8435 −3.023 0.002503 0.8353 0.24446 0.21477 0.2678 rs10758326 Imputed A ADD 679 0.73 0.1149 0.5831 0.9149 −2.734 0.006266 0.7443 0.37923 0.33893 0.4108 rs10758326 Imputed A GEN 679 8.015 0.01818 0.7443 0.37923 0.33893 0.4108 rs10758326 Imputed A REC 679 0.554 0.2314 0.3523 0.8726 −2.549 0.01081 0.7443 0.37923 0.33893 0.4108 rs10762236 Genotyped G ADD 682 0.583 0.1422 0.4409 0.77 −3.797 0.000146 0.0221 0.19941 0.15 0.2382 rs10765769 Imputed C ADD 676 1.445 0.1127 1.159 1.802 3.266 0.001089 0.6368 0.42456 0.47475 0.3852 rs10765769 Imputed C GEN 676 10.87 0.004364 0.6368 0.42456 0.47475 0.3852 rs10784891 Imputed C ADD 656 0.692 0.117 0.5504 0.8705 −3.146 0.001655 0.5819 0.45503 0.40972 0.4905 rs10784891 Imputed C DOM 656 0.57 0.1761 0.4039 0.8053 −3.19 0.001424 0.5819 0.45503 0.40972 0.4905 rs10787923 Imputed G DOM 672 1.834 0.1588 1.343 2.504 3.819 0.000134 1 0.29464 0.33502 0.2627 rs10787949 Imputed A DOM 682 1.79 0.1585 1.312 2.442 3.671 0.000241 1 0.30132 0.34 0.2709 rs10787951 Imputed G DOM 682 1.79 0.1585 1.312 2.442 3.671 0.000241 1 0.30132 0.34 0.2709 rs10787983 Imputed C DOM 682 1.786 0.1574 1.312 2.431 3.685 0.000229 1 0.29545 0.335 0.2644 rs10788380 Imputed C ADD 675 1.411 0.1153 1.125 1.769 2.984 0.002844 0.2184 0.49333 0.53716 0.4591 rs10788380 Imputed C DOM 675 1.762 0.1889 1.217 2.552 2.999 0.002704 0.2184 0.49333 0.53716 0.4591 rs10788380 Imputed C GEN 675 9.862 0.007218 0.2184 0.49333 0.53716 0.4591 rs10814418 Imputed G DOM 680 0.533 0.2074 0.3547 0.7998 −3.037 0.002389 0.6755 0.10221 0.07383 0.1243 rs10831417 Imputed A ADD 674 1.436 0.1147 1.147 1.798 3.154 0.001613 0.8092 0.39688 0.44463 0.359 rs10831417 Imputed A GEN 674 10.39 0.005538 8.09E−01 0.39688 0.44463 0.359 rs10831422 Imputed C ADD 676 1.421 0.1143 1.135 1.777 3.071 0.002131 0.8726 0.39941 0.44631 0.3624 rs10831422 Imputed C GEN 676 9.86 0.007226 0.8726 0.39941 0.44631 0.3624 rs10862931 Imputed C GEN 676 12.36 0.002073 0.2988 0.33284 0.28885 0.3671 rs10865197 Imputed C DOM 679 1.604 0.1581 1.177 2.186 2.988 0.002806 0.04888 0.24448 0.27609 0.2199 rs10871302 Imputed A DOM 677 1.561 0.1787 1.099 2.215 2.49 0.01276 0.5241 0.13959 0.16498 0.1197 rs10877463 Imputed C DOM 681 0.735 0.1583 0.5392 1.003 −1.941 0.05228 0.1829 0.35756 0.34281 0.3691 rs10877468 Imputed C DOM 681 0.745 0.1584 0.5465 1.017 −1.855 0.06358 0.2438 0.35756 0.34448 0.3678 rs10879240 Imputed C ADD 561 0.604 0.1586 0.4424 0.824 −3.18 0.001472 1.43E−14 0.34581 0.30632 0.3782 rs10879242 Imputed A DOM 600 0.502 0.1832 0.3504 0.7186 −3.764 0.000167 1 0.45083 0.41098 0.4821 rs10879245 Imputed G DOM 600 0.502 0.1832 0.3504 0.7186 −3.764 0.000167 1 0.45083 0.41098 0.4821 rs10879249 Imputed T DOM 676 0.583 0.1653 0.4214 0.8058 −3.266 0.001091 0.9363 0.40385 0.36745 0.4325 rs10886452 Imputed A DOM 682 1.79 0.1585 1.312 2.442 3.671 0.000241 1 0.30132 0.34 0.2709 rs10886463 Imputed C DOM 682 1.79 0.1585 1.312 2.442 3.671 0.000241 1 0.30132 0.34 0.2709 rs10886465 Imputed A DOM 682 1.778 0.1589 1.302 2.427 3.622 0.000293 0.9278 0.30279 0.34 0.2736 rs10886526 Imputed C DOM 681 1.762 0.1577 1.293 2.4 3.591 0.000329 1 0.29589 0.33278 0.267 rs10902437 Imputed G ADD 658 1.415 0.1115 1.137 1.761 3.113 0.001853 0.03266 0.38754 0.43857 0.3466 rs10941126 Imputed G ADD 682 0.187 0.4378 0.0793 0.441 −3.83 0.000128 0.06181 0.03739 0.015 0.055 rs10941126 Imputed G DOM 682 0.19 0.451 0.0786 0.4606 −3.679 0.000234 0.06181 0.03739 0.015 0.055 rs10947871 Imputed A DOM 682 1.569 0.1754 1.112 2.213 2.567 0.01026 0.1579 0.14223 0.16667 0.123 rs10972978 Imputed G DOM 658 0.518 0.2117 0.3418 0.7839 −3.11 0.001873 0.6698 0.10258 0.07292 0.1257 rs10973012 Imputed A DOM 682 0.529 0.2074 0.352 0.7937 −3.074 0.00211 0.6748 0.10191 0.07333 0.1243 rs10974028 Genotyped G ADD 682 0.605 0.1547 0.4467 0.8194 −3.247 0.001165 0.3256 0.16349 0.125 0.1937 rs10974028 Genotyped G DOM 682 0.516 0.1777 0.3642 0.7308 −3.725 0.000196 0.3256 0.16349 0.125 0.1937 rs11021302 Imputed A ADD 681 1.413 0.1142 1.13 1.768 3.029 0.002455 0.873 0.39794 0.44333 0.3622 rs11021302 Imputed A GEN 681 9.725 0.007733 0.873 0.39794 0.44333 0.3622 rs11099644 Imputed G REC 668 1.905 0.2304 1.213 2.992 2.798 0.005138 0.4004 0.35853 0.36735 0.3516 rs11138315 Imputed G ADD 646 0.682 0.1861 0.4732 0.9815 −2.06 0.03937 0.2275 0.11068 0.09123 0.126 rs11149802 Imputed T DOM 677 1.561 0.1787 1.099 2.215 2.49 0.01276 0.5241 0.13959 0.16498 0.1197 rs1116596 Imputed T DOM 681 0.551 0.1595 0.4029 0.753 −3.738 0.000186 1 0.34802 0.30667 0.3806 rs11178531 Imputed A ADD 678 0.722 0.1139 0.5774 0.9022 −2.863 0.004194 0.7006 0.47788 0.43624 0.5105 rs11178531 Imputed A DOM 678 0.557 0.1766 0.3942 0.7879 −3.31 0.000934 0.7006 0.47788 0.43624 0.5105 rs11178575 Imputed C GEN 679 9.118 0.01047 0.5966 0.31885 0.35067 0.294 rs11178575 Imputed C REC 679 2.174 0.2571 1.313 3.598 3.019 0.002532 0.5966 0.31885 0.35067 0.294 rs11178577 Imputed T GEN 680 9.117 0.01048 0.6589 0.31912 0.35067 0.2945 rs11178577 Imputed T REC 680 2.173 0.2571 1.313 3.597 3.019 0.002537 0.6589 0.31912 0.35067 0.2945 rs11178583 Imputed A DOM 665 0.567 0.1672 0.4082 0.7862 −3.399 0.000677 1 0.40827 0.37113 0.4372 rs11178589 Imputed T DOM 678 0.593 0.1662 0.4283 0.8217 −3.142 0.001679 1 0.41593 0.3796 0.4446 rs11178594 Imputed C DOM 680 0.579 0.1651 0.4187 0.7999 −3.312 0.000926 0.9365 0.40294 0.36745 0.4306 rs11178602 Imputed T DOM 680 0.57 0.165 0.4126 0.788 −3.404 0.000665 0.8735 0.40221 0.36577 0.4306 rs11178648 Imputed T DOM 680 0.564 0.1631 0.4095 0.7761 −3.514 0.000442 0.8107 0.40074 0.36622 0.4278 rs11198877 Imputed T DOM 682 1.79 0.1585 1.312 2.442 3.671 0.000241 1 0.30132 0.34 0.2709 rs11198942 Imputed T DOM 680 1.797 0.1579 1.319 2.449 3.712 0.000206 1 0.29706 0.33612 0.2664 rs11221075 Imputed A ADD 674 0.628 0.1738 0.4466 0.8827 −2.678 0.007404 0.4847 0.12685 0.09966 0.1481 rs11242020 Imputed T DOM 682 0.548 0.1595 0.4011 0.7494 −3.769 0.000164 0.9329 0.34824 0.30667 0.3809 rs11242021 Imputed T DOM 682 0.56 0.1597 0.4098 0.7664 −3.626 0.000288 0.9329 0.34824 0.30833 0.3796 rs11242022 Imputed T DOM 682 0.56 0.1597 0.4098 0.7664 −3.626 0.000288 0.9329 0.34824 0.30833 0.3796 rs11242023 Imputed T DOM 682 0.564 0.1596 0.4123 0.7707 −3.592 0.000328 1 0.34531 0.30667 0.3757 rs1149350 Imputed A DOM 680 1.537 0.1609 1.121 2.106 2.672 0.007551 0.1324 0.21029 0.23913 0.1877 rs1150143 Imputed G DOM 658 1.631 0.1628 1.186 2.245 3.007 0.002639 0.1849 0.32827 0.35366 0.3086 rs11576627 Imputed T ADD 682 1.785 0.1742 1.268 2.511 3.325 0.000885 0.05306 0.12463 0.15833 0.0982 rs11576627 Imputed T DOM 682 1.844 0.1815 1.292 2.632 3.373 0.000744 0.05306 0.12463 0.15833 0.0982 rs11602189 Imputed A DOM 677 0.604 0.1575 0.4435 0.8223 −3.203 0.001362 0.5429 0.32939 0.2862 0.3632 rs11605163 Imputed A DOM 679 2.068 0.229 1.32 3.239 3.173 0.001509 0.7687 0.07143 0.09532 0.0526 rs11615214 Imputed G ADD 660 0.645 0.1143 0.5156 0.807 −3.837 0.000125 0.02544 0.37652 0.31507 0.4253 rs11615214 Imputed G GEN 660 15.05 0.000541 0.02544 0.37652 0.31507 0.4253 rs11642394 Imputed C DOM 677 1.561 0.1787 1.099 2.215 2.49 0.01276 0.5241 0.13959 0.16498 0.1197 rs11644943 Imputed A ADD 655 1.327 0.1361 1.017 1.733 2.081 0.03739 0.6522 0.22214 0.24829 0.2011 rs11656608 Imputed T DOM 681 0.649 0.1794 0.4567 0.9228 −2.408 0.01605 1 0.14317 0.12375 0.1584 rs11661309 Imputed A ADD 676 0.626 0.1446 0.4718 0.8317 −3.234 0.00122 0.6206 0.19231 0.15152 0.2243 rs11661309 Imputed A DOM 676 0.601 0.1674 0.4325 0.8338 −3.046 0.002323 0.6206 0.19231 0.15152 0.2243 rs11666131 Imputed A ADD 675 1.512 0.136 1.158 1.974 3.04 0.002366 0.4389 0.22444 0.26102 0.1961 rs11743355 Imputed C ADD 650 0.164 0.4716 0.0652 0.4139 −3.83 0.000128 0.05102 0.03692 0.01394 0.0551 rs11743355 Imputed C DOM 650 0.166 0.4861 0.064 0.4303 −3.695 0.00022 0.05102 0.03692 0.01394 0.0551 rs11746806 Imputed T ADD 682 0.217 0.4129 0.0965 0.4867 −3.704 0.000213 0.06816 0.03812 0.01667 0.055 rs11746806 Imputed T DOM 682 0.223 0.4255 0.0967 0.5123 −3.532 0.000412 0.06816 0.03812 0.01667 0.055 rs11746959 Imputed T ADD 682 0.187 0.4378 0.0793 0.441 −3.83 0.000128 0.06181 0.03739 0.015 0.055 rs11746959 Imputed T DOM 682 0.19 0.451 0.0786 0.4606 −3.679 0.000234 0.06181 0.03739 0.015 0.055 rs11749272 Imputed T DOM 679 0.552 0.16 0.4036 0.7559 −3.709 0.000208 1 0.34831 0.30705 0.3806 rs11901899 Imputed A DOM 668 1.459 0.1585 1.069 1.99 2.382 0.0172 1 0.26422 0.29223 0.2419 rs11926319 Imputed G ADD 675 0.479 0.2053 0.3205 0.7167 −3.583 0.00034 0.8261 0.09778 0.06397 0.1243 rs11926319 Imputed G DOM 675 0.466 0.2155 0.3052 0.7104 −3.546 0.000391 0.8261 0.09778 0.06397 0.1243 rs11956952 Imputed C DOM 671 0.633 0.1593 0.4632 0.8648 −2.872 0.00408 0.7761 0.28465 0.24662 0.3147 rs12025826 Imputed G DOM 664 1.73 0.166 1.249 2.395 3.3 0.000968 0.05275 0.40286 0.45313 0.3644 rs1204522 Imputed C GEN 676 11.67 0.002917 0.87 0.37796 0.33054 0.4153 rs1204524 Imputed A GEN 678 11.89 0.002625 0.8065 0.37832 0.33054 0.4158 rs12153185 Imputed T DOM 672 0.561 0.1605 0.4097 0.7686 −3.6 0.000319 0.9321 0.34598 0.3064 0.3773 rs12182651 Imputed T ADD 678 2.104 0.213 1.386 3.194 3.492 0.000479 0.6166 0.08481 0.11371 0.062 rs12182651 Imputed T DOM 678 2.304 0.2264 1.478 3.592 3.687 0.000227 0.6166 0.08481 0.11371 0.062 rs12193568 Imputed G DOM 565 1.551 0.1819 1.086 2.215 2.413 0.01581 0.3148 0.17788 0.20751 0.1538 rs12264914 Imputed C DOM 361 0.591 0.2158 0.3873 0.9024 −2.436 0.01486 0.08135 0.34349 0.29063 0.3856 rs12307767 Imputed C DOM 661 0.729 0.1608 0.532 0.9993 −1.964 0.04953 0.2737 0.36157 0.34589 0.374 rs1232298 Imputed G REC 658 1.65 0.2751 0.9623 2.829 1.82 0.06874 0.2441 0.31839 0.32118 0.3162 rs12407412 Imputed C ADD 682 1.785 0.1742 1.268 2.511 3.325 0.000885 0.05306 0.12463 0.15833 0.0982 rs12407412 Imputed C DOM 682 1.844 0.1815 1.292 2.632 3.373 0.000744 0.05306 0.12463 0.15833 0.0982 rs12420184 Imputed G DOM 681 0.542 0.1789 0.3816 0.7695 −3.424 0.000617 0.4694 0.15639 0.125 0.1811 rs12422750 Imputed A DOM 679 0.756 0.1585 0.5538 1.031 −1.769 0.07688 0.1821 0.35935 0.34564 0.3701 rs12446951 Imputed A ADD 520 2.018 0.2623 1.207 3.375 2.678 0.007409 0.4988 0.06923 0.09389 0.0498 rs12446951 Imputed A DOM 520 2.001 0.2641 1.192 3.358 2.626 0.008639 0.4988 0.06923 0.09389 0.0498 rs12457400 Imputed G DOM 680 0.553 0.201 0.3727 0.8196 −2.95 0.003178 0.6917 0.10882 0.08361 0.1286 rs1247340 Imputed C DOM 680 1.537 0.1609 1.121 2.106 2.672 0.007551 0.1324 0.21029 0.23913 0.1877 rs1247341 Imputed C DOM 680 1.537 0.1609 1.121 2.106 2.672 0.007551 0.1324 0.21029 0.23913 0.1877 rs12521291 Imputed G ADD 673 0.684 0.1186 0.5424 0.8634 −3.198 0.001382 0.4434 0.34398 0.30034 0.3787 rs12526849 Imputed T ADD 656 1.462 0.113 1.172 1.825 3.364 0.000769 0.2246 0.40473 0.45819 0.3631 rs12526849 Imputed T GEN 656 11.33 0.003474 0.2246 0.40473 0.45819 0.3631 rs12543110 Imputed G DOM 681 1.542 0.1596 1.127 2.108 2.712 0.006696 0.106 0.23128 0.25585 0.212 rs12678600 Imputed A DOM 675 0.617 0.1585 0.4524 0.8419 −3.046 0.002319 0.7936 0.32889 0.28859 0.3607 rs12719415 Imputed T DOM 673 0.546 0.1604 0.3989 0.748 −3.771 0.000163 0.548 0.34027 0.29522 0.375 rs12831292 Imputed G DOM 678 0.574 0.1652 0.4153 0.7936 −3.359 0.000782 0.9364 0.40339 0.367 0.4318 rs12923993 Imputed C DOM 677 1.561 0.1787 1.099 2.215 2.49 0.01276 0.5241 0.13959 0.16498 0.1197 rs12936964 Imputed T DOM 673 1.718 0.1622 1.25 2.362 3.338 0.000844 0.6161 0.35958 0.40372 0.3249 rs12960663 Imputed G ADD 672 0.639 0.1447 0.4809 0.8478 −3.101 0.001927 0.5336 0.19122 0.15203 0.2221 rs13038146 Imputed C ADD 681 1.338 0.1141 1.07 1.674 2.554 0.01063 0.2789 0.3583 0.39667 0.3281 rs13038146 Imputed C GEN 681 7.872 0.01953 0.2789 0.3583 0.39667 0.3281 rs13134222 Imputed A GEN 597 9.274 0.009687 0.917 0.26884 0.23408 0.297 rs13172910 Imputed A DOM 675 0.633 0.159 0.4637 0.8646 −2.875 0.004042 0.7779 0.28667 0.25 0.3156 rs13194907 Imputed A ADD 682 2.264 0.2373 1.422 3.606 3.444 0.000573 0.205 0.06598 0.09167 0.0458 rs13194907 Imputed A DOM 682 2.432 0.2521 1.484 3.986 3.525 0.000423 0.205 0.06598 0.09167 0.0458 rs13195745 Imputed A ADD 682 2.264 0.2373 1.422 3.606 3.444 0.000573 0.205 0.06598 0.09167 0.0458 rs13195745 Imputed A DOM 682 2.432 0.2521 1.484 3.986 3.525 0.000423 0.205 0.06598 0.09167 0.0458 rs1321432 Imputed A REC 681 2.324 0.2254 1.494 3.615 3.741 0.000183 0.5731 0.3884 0.44314 0.3455 rs1321457 Imputed G REC 665 2.293 0.2272 1.469 3.58 3.653 0.000259 0.7441 0.38872 0.44178 0.3472 rs13265054 Imputed T DOM 671 0.623 0.1591 0.4561 0.8511 −2.973 0.002945 0.7921 0.32489 0.28716 0.3547 rs13282131 Imputed C GEN 675 7.767 0.02058 0.8765 0.44889 0.48639 0.4199 rs13353526 Imputed C DOM 674 1.752 0.2045 1.174 2.617 2.743 0.006085 0.3687 0.09496 0.11486 0.0794 rs1336382 Imputed T DOM 682 1.772 0.1576 1.301 2.413 3.63 2.84E−04 1 0.29692 0.335 0.267 rs1336383 Imputed T DOM 682 1.772 0.1576 1.301 2.413 3.63 0.000284 1 0.29692 0.335 0.267 rs1336407 Imputed T DOM 682 1.772 0.1576 1.301 2.413 3.63 0.000284 1 0.29692 0.335 0.267 rs1336409 Imputed T DOM 682 1.772 0.1576 1.301 2.413 3.63 0.000284 1 0.29692 0.335 0.267 rs1336596 Imputed A DOM 682 0.565 0.1607 0.412 0.7735 −3.558 0.000374 0.9327 0.34751 0.31333 0.3743 rs1343560 Imputed T ADD 678 0.521 0.1923 0.3575 0.7596 −3.39 0.000699 0.3076 0.10546 0.07239 0.1312 rs1343560 Imputed T DOM 678 0.478 0.2098 0.3168 0.7211 −3.518 0.000435 0.3076 0.10546 0.07239 0.1312 rs1361987 Imputed T GEN 682 12.45 0.001975 0.9355 0.3849 0.335 0.4241 rs1386153 Imputed T ADD 677 0.694 0.1194 0.5493 0.8772 −3.057 0.002235 0.7936 0.32718 0.28261 0.3624 rs1386153 Imputed T DOM 677 0.603 0.1574 0.4431 0.8213 −3.21 0.001326 0.7936 0.32718 0.28261 0.3624 rs1394015 Imputed C DOM 669 1.658 0.1636 1.203 2.285 3.091 0.001993 0.4527 0.36472 0.39384 0.3422 rs1407038 Imputed A REC 678 2.31 0.2263 1.483 3.599 3.7 0.000215 0.8076 0.38422 0.4375 0.3429 rs1407039 Imputed A REC 680 2.185 0.221 1.417 3.37 3.538 4.04E−04 0.748 0.39412 0.44631 0.3534 rs1412802 Imputed T GEN 681 6.558 0.03767 0.785 0.30176 0.27 0.3268 rs1414865 Imputed T DOM 682 1.79 0.1585 1.312 2.442 3.671 0.000241 1 0.30132 0.34 0.2709 rs1414873 Imputed A DOM 682 1.786 0.1574 1.312 2.431 3.685 0.000229 1 0.29545 0.335 0.2644 rs1414876 Imputed C DOM 682 1.786 0.1574 1.312 2.431 3.685 0.000229 1 0.29545 0.335 0.2644 rs1418671 Imputed C REC 655 2.259 0.2305 1.437 3.549 3.534 0.000409 0.2728 0.36336 0.41493 0.3229 rs1419490 Genotyped T GEN 682 12.66 0.001783 0.9357 0.38416 0.33333 0.4241 rs1434507 Imputed A ADD 681 1.547 0.1268 1.206 1.983 3.439 0.000584 0.8411 0.25698 0.30333 0.2205 rs1434508 Imputed T ADD 681 1.536 0.1268 1.198 1.97 3.388 0.000705 0.9202 0.25771 0.30333 0.2218 rs1435205 Imputed A ADD 679 1.5 0.1343 1.153 1.952 3.019 0.00254 1 0.21944 0.25671 0.1903 rs1443928 Imputed C REC 672 0.59 0.1812 0.4133 0.8409 −2.917 0.003539 0.5875 0.53571 0.50169 0.5625 rs1452235 Imputed G GEN 682 12.53 0.001899 0.2617 0.33065 0.28667 0.3652 rs1452236 Imputed G GEN 681 12.63 0.001811 0.2989 0.33113 0.28667 0.3661 rs1452237 Imputed G GEN 682 12.53 0.001899 0.2617 0.33065 0.28667 0.3652 rs1452243 Genotyped T GEN 682 12.53 0.001899 0.2617 0.33065 0.28667 0.3652 rs1463768 Genotyped G REC 682 1.527 0.2037 1.025 2.277 2.08 0.03755 0.3847 0.40982 0.435 0.3901 rs1463769 Imputed G REC 682 1.561 0.2044 1.045 2.33 2.177 0.02947 0.428 0.40836 0.435 0.3874 rs1472435 Imputed A ADD 675 0.581 0.2266 0.3727 0.9061 −2.395 0.01663 0.3725 0.07111 0.05201 0.0862 rs1472435 Imputed A DOM 675 0.6 0.2382 0.376 0.9566 −2.146 0.03185 0.3725 0.07111 0.05201 0.0862 rs1476714 Imputed A DOM 681 0.558 0.1599 0.4076 0.7628 −3.654 0.000258 1 0.34802 0.30769 0.3796 rs1495159 Imputed G ADD 671 0.664 0.125 0.5195 0.8479 −3.281 0.001036 0.8591 0.31967 0.27721 0.3528 rs1495159 Imputed G GEN 671 11.32 0.003475 0.8591 0.31967 0.27721 0.3528 rs1495375 Imputed A DOM 674 0.571 0.1673 0.4111 0.7921 −3.353 0.0008 1 0.42507 0.3902 0.4524 rs1495376 Imputed T DOM 649 0.594 0.1848 0.4134 0.8529 −2.821 0.004787 0.8753 0.4923 0.46986 0.5095 rs1495377 Imputed G DOM 652 0.615 0.1836 0.4294 0.8819 −2.644 0.008185 0.9375 0.49233 0.47183 0.5082 rs1495381 Imputed T GEN 682 10.43 0.005444 0.3777 0.39443 0.43 0.3665 rs1495381 Imputed T REC 682 2.043 0.2213 1.324 3.152 3.229 0.001243 0.3777 0.39443 0.43 0.3665 rs1498992 Imputed G DOM 681 0.583 0.1567 0.4286 0.7922 −3.446 0.000568 0.4296 0.32159 0.27592 0.3573 rs1499001 Imputed T DOM 661 0.587 0.1603 0.4291 0.8042 −3.32 0.000901 0.5609 0.27761 0.22837 0.3159 rs1512988 Imputed A DOM 681 0.588 0.1643 0.4264 0.8118 −3.229 0.001243 0.9365 0.40088 0.36455 0.4293 rs1512989 Imputed T DOM 681 0.588 0.1643 0.4264 0.8118 −3.229 0.001243 0.9365 0.40088 0.36455 0.4293 rs1512991 Imputed T ADD 677 0.734 0.1143 0.5865 0.9181 −2.707 0.006791 0.6434 0.46824 0.42929 0.4987 rs1512991 Imputed T DOM 677 0.588 0.1751 0.4173 0.8289 −3.032 0.002431 0.6434 0.46824 0.42929 0.4987 rs1516855 Imputed G REC 657 1.965 0.2424 1.222 3.16 2.786 0.005328 0.1374 0.38052 0.41176 0.356 rs1527450 Imputed T ADD 670 1.426 0.1148 1.139 1.787 3.093 0.001982 0.7474 0.39776 0.44463 0.3602 rs1527450 Imputed T GEN 670 9.977 0.006814 0.7474 0.39776 0.44463 0.3602 rs1567740 Imputed T DOM 679 0.584 0.165 0.4224 0.8064 −3.264 0.001098 0.8732 0.40206 0.367 0.4293 rs1572573 Imputed A ADD 657 1.745 0.1419 1.321 2.305 3.923 8.73E−05 0.1585 0.18798 0.23693 0.15 rs1572573 Imputed A DOM 657 2.014 0.1694 1.445 2.807 4.132 3.60E−05 0.1585 0.18798 0.23693 0.15 rs1584003 Imputed C DOM 673 1.97 0.1803 1.384 2.806 3.761 0.000169 0.2788 0.47028 0.5119 0.438 rs1584005 Imputed C DOM 665 1.936 0.181 1.358 2.761 3.652 0.000261 0.2759 0.46842 0.50692 0.4388 rs1585771 Imputed G ADD 674 1.481 0.1242 1.161 1.889 3.162 0.001567 0.3712 0.26261 0.30678 0.2282 rs1592015 Imputed G DOM 681 0.523 0.1726 0.373 0.7337 −3.754 0.000174 0.43 0.17621 0.13712 0.2068 rs1594885 Imputed A ADD 681 1.561 0.1254 1.221 1.995 3.551 0.000384 0.6918 0.26211 0.31 0.2244 rs1603232 Imputed A DOM 655 0.631 0.1827 0.4408 0.902 −2.525 0.01159 1 0.48779 0.47038 0.5014 rs1614565 Imputed C DOM 671 0.574 0.1797 0.4034 0.816 −3.091 0.001993 0.9385 0.48957 0.46949 0.5053 rs1648200 Imputed G ADD 623 1.473 0.135 1.13 1.919 2.868 0.004134 0.833 0.25522 0.29478 0.2254 rs16877387 Imputed C GEN 677 11.65 0.002959 0.3017 0.33678 0.38047 0.3026 rs16877387 Imputed C REC 677 2.249 0.2423 1.399 3.616 3.345 0.000823 0.3017 0.33678 0.38047 0.3026 rs16938626 Imputed G DOM 663 0.631 0.1588 0.4625 0.8618 −2.897 0.00377 0.9255 0.29261 0.25676 0.3215 rs1694334 Imputed G ADD 599 0.664 0.1373 0.5072 0.8688 −2.984 0.002847 0.01892 0.24207 0.1954 0.2781 rs16998821 Imputed C DOM 681 0.523 0.1726 0.373 0.7337 −3.754 0.000174 0.43 0.17621 0.13712 0.2068 rs1700400 Imputed T ADD 672 0.695 0.131 0.5378 0.8989 −2.774 0.005544 0.5481 0.25967 0.22297 0.2886 rs17007620 Imputed G ADD 599 1.567 0.1431 1.184 2.074 3.138 0.001699 0.8194 0.23372 0.27308 0.2035 rs17007620 Imputed G DOM 599 1.743 0.171 1.247 2.437 3.251 0.001149 0.8194 0.23372 0.27308 0.2035 rs17023290 Imputed C DOM 682 1.705 0.2034 1.144 2.541 2.623 0.008711 0.3705 0.09457 0.11333 0.0798 rs17047957 Imputed C DOM 681 1.493 0.168 1.074 2.074 2.384 0.01712 0.4202 0.17181 0.19231 0.1558 rs1705237 Imputed A DOM 666 0.566 0.1803 0.3973 0.8057 −3.158 0.001589 0.8767 0.48649 0.4622 0.5053 rs1705261 Imputed A GEN 682 10.46 0.005353 0.4226 0.39296 0.43 0.3639 rs1705261 Imputed A REC 682 2.043 0.2213 1.324 3.152 3.229 0.001243 0.4226 0.39296 0.43 0.3639 rs17076972 Imputed C ADD 682 1.427 0.1121 1.146 1.778 3.172 0.001511 1 0.47507 0.52667 0.4346 rs17076972 Imputed C GEN 682 11.26 0.003593 1 0.47507 0.52667 0.4346 rs17076972 Imputed C REC 682 1.816 0.1863 1.26 2.616 3.202 0.001365 1 0.47507 0.52667 0.4346 rs17189710 Imputed T ADD 681 1.338 0.1141 1.07 1.674 2.554 0.01063 0.2789 0.3583 0.39667 0.3281 rs17189710 Imputed T GEN 681 7.872 0.01953 0.2789 0.3583 0.39667 0.3281 rs17196143 Imputed A ADD 682 1.57 0.1416 1.189 2.072 3.183 0.001458 0.6286 0.19721 0.23667 0.1662 rs17353809 Imputed G ADD 674 1.511 0.1348 1.16 1.968 3.062 0.002199 0.9094 0.21588 0.25424 0.186 rs17368986 Imputed A GEN 682 13.99 0.000919 0.07037 0.19721 0.24167 0.1623 rs17369097 Imputed A GEN 681 13.12 0.001413 0.1414 0.19457 0.23833 0.1601 rs17434511 Imputed C GEN 679 13.93 0.000944 0.06935 0.19735 0.24161 0.1627 rs17434589 Imputed C GEN 673 14.2 0.000826 0.06943 0.19837 0.24407 0.1627 rs17434603 Imputed G GEN 680 13.78 0.001017 0.06901 0.19706 0.2408 0.1627 rs17434840 Imputed C GEN 681 13.12 0.001413 0.1414 0.19457 0.23833 0.1601 rs17446418 Imputed G DOM 678 0.537 0.1603 0.3921 0.7351 −3.88 0.000105 0.8045 0.36873 0.31711 0.4092 rs17530747 Imputed T DOM 669 0.525 0.1614 0.383 0.7209 −3.988 6.66E−05 0.8027 0.36398 0.30887 0.4069 rs17604285 Imputed C ADD 681 0.533 0.1972 0.3619 0.7838 −3.195 0.001397 0.2868 0.09912 0.06833 0.1234 rs17604285 Imputed C DOM 681 0.504 0.212 0.3327 0.7638 −3.231 0.001233 0.2868 0.09912 0.06833 0.1234 rs17662322 Imputed T DOM 681 0.555 0.17 0.3978 0.7746 −3.463 0.000535 1 0.18135 0.13712 0.216 rs17769826 Imputed T ADD 677 1.504 0.1347 1.155 1.958 3.029 0.002453 0.9092 0.21492 0.25253 0.1855 rs17821641 Imputed T ADD 679 1.5 0.1343 1.153 1.952 3.019 0.00254 1 0.21944 0.25671 0.1903 rs1782328 Imputed A ADD 647 0.613 0.1454 0.4609 0.8148 −3.369 0.000754 0.1051 0.19706 0.15194 0.2321 rs1796337 Imputed T DOM 669 0.597 0.1833 0.4168 0.8548 −2.816 0.004863 0.5361 0.51121 0.48142 0.5349 rs1798083 Imputed C DOM 674 0.601 0.179 0.4232 0.8536 −2.845 0.004447 0.8775 0.48813 0.46959 0.5026 rs1798085 Imputed T DOM 668 0.578 0.1804 0.4058 0.823 −3.04 0.002368 0.9383 0.48952 0.46928 0.5053 rs1798086 Imputed T DOM 668 0.553 0.1797 0.3886 0.786 −3.3 0.000968 1 0.48653 0.46246 0.5053 rs1798089 Imputed C GEN 675 11.13 0.00383 0.42 0.39333 0.43098 0.3638 rs1798089 Imputed C REC 675 2.101 0.2227 1.358 3.252 3.334 0.000855 0.42 0.39333 0.43098 0.3638 rs1798090 Imputed C GEN 674 10.63 0.004921 0.3765 0.39614 0.43412 0.3664 rs1798090 Imputed C REC 674 2.054 0.2214 1.331 3.17 3.251 0.001151 0.3765 0.39614 0.43412 0.3664 rs1832222 Imputed G DOM 682 1.786 0.1574 1.312 2.431 3.685 0.000229 1 0.29545 0.335 0.2644 rs1838104 Imputed A ADD 668 0.727 0.1159 0.5791 0.9121 −2.754 0.005895 0.3083 0.55539 0.51199 0.5891 rs1838104 Imputed A GEN 668 7.983 0.01848 0.3083 0.55539 0.51199 0.5891 rs1868616 Imputed G ADD 671 0.572 0.1501 0.426 0.7672 −3.725 0.000195 0.7063 0.19001 0.14576 0.2247 rs1874313 Imputed A DOM 674 0.578 0.1655 0.4178 0.7993 −3.314 0.000921 0.9364 0.40504 0.36824 0.4339 rs1884902 Imputed C REC 678 2.217 0.2224 1.434 3.428 3.579 0.000344 0.6303 0.39381 0.44649 0.3522 rs1913201 Imputed G ADD 650 0.692 0.1185 0.5487 0.873 −3.106 0.001894 0.3832 0.44692 0.40175 0.4822 rs1913201 Imputed G DOM 650 0.589 0.1754 0.4175 0.8303 −3.02 0.002528 0.3832 0.44692 0.40175 0.4822 rs1913201 Imputed G GEN 650 10.22 0.006038 0.3832 0.44692 0.40175 0.4822 rs1944279 Imputed A ADD 679 1.579 0.1261 1.233 2.022 3.624 0.00029 0.6914 0.26068 0.30936 0.2224 rs198461 Imputed C DOM 676 0.625 0.1925 0.4287 0.9117 −2.44 0.01467 0.04501 0.52367 0.49495 0.5462 rs1987179 Imputed T DOM 680 0.701 0.1613 0.5109 0.9616 −2.203 0.0276 0.06175 0.20735 0.18562 0.2244 rs1990023 Imputed T DOM 682 0.548 0.1595 0.4011 0.7494 −3.769 0.000164 0.9329 0.34824 0.30667 0.3809 rs2016194 Imputed G DOM 682 0.56 0.1597 0.4098 0.7664 −3.626 0.000288 0.9329 0.34824 0.30833 0.3796 rs2024789 Imputed C ADD 666 0.675 0.1123 0.542 0.8417 −3.495 0.000475 0.3902 0.4542 0.39828 0.4973 rs2024789 Imputed C GEN 666 12.34 0.002095 0.3902 0.4542 0.39828 0.4973 rs2024902 Imputed A ADD 678 2.07 0.2296 1.32 3.246 3.168 0.001535 0.2503 0.07375 0.09732 0.0553 rs2024902 Imputed A DOM 678 2.266 0.2451 1.401 3.663 3.336 0.000849 0.2503 0.07375 0.09732 0.0553 rs2025107 Imputed A ADD 682 2.008 0.2082 1.336 3.02 3.35 0.000808 0.4997 0.09238 0.12 0.0707 rs2025107 Imputed A DOM 682 2.219 0.2217 1.437 3.427 3.596 0.000324 0.4997 0.09238 0.12 0.0707 rs2025108 Imputed T ADD 682 2.008 0.2082 1.336 3.02 3.35 0.000808 0.4997 0.09238 0.12 0.0707 rs2025108 Imputed T DOM 682 2.219 0.2217 1.437 3.427 3.596 0.000324 0.4997 0.09238 0.12 0.0707 rs2062448 Imputed T ADD 674 0.545 0.1992 0.3687 0.805 −3.049 0.002299 0.2633 0.09644 0.06711 0.1197 rs2062448 Imputed T DOM 674 0.517 0.215 0.339 0.7873 −3.072 0.002123 0.2633 0.09644 0.06711 0.1197 rs2063591 Imputed C ADD 677 0.73 0.1136 0.5839 0.9113 −2.777 0.005479 0.8173 0.47858 0.43792 0.5106 rs2063591 Imputed C DOM 677 0.56 0.1767 0.3958 0.7911 −3.287 0.001014 0.8173 0.47858 0.43792 0.5106 rs2065604 Imputed C DOM 682 0.529 0.2074 0.352 0.7937 −3.074 0.00211 0.6748 0.10191 0.07333 0.1243 rs2066238 Imputed T DOM 682 0.521 0.1725 0.3715 0.7305 −3.78 0.000157 0.4294 0.17595 0.13667 0.2068 rs2068051 Imputed G ADD 424 0.612 0.1413 0.464 0.8076 −3.472 0.000517 0.1925 0.58726 0.52332 0.6407 rs2068051 Imputed G GEN 424 12.06 0.002411 0.1925 0.58726 0.52332 0.6407 rs2077702 Genotyped G GEN 682 9.004 0.01108 0.5971 0.31818 0.35 0.2932 rs208757 Imputed G ADD 652 1.552 0.1511 1.154 2.087 2.91 0.003619 0.4981 0.17485 0.20833 0.1484 rs208757 Imputed G DOM 652 1.649 0.1701 1.182 2.302 2.942 0.003266 0.4981 0.17485 0.20833 0.1484 rs2095586 Imputed A DOM 682 1.786 0.1574 1.312 2.431 3.685 0.000229 1 0.29545 0.335 0.2644 rs2108426 Imputed C DOM 682 0.56 0.1597 0.4098 0.7664 −3.626 0.000288 0.9329 0.34824 0.30833 0.3796 rs2110664 Imputed A DOM 643 1.503 0.1611 1.096 2.061 2.53 0.01141 0.8422 0.27138 0.30674 0.2438 rs2132242 Imputed A DOM 680 0.585 0.1661 0.4222 0.8097 −3.231 0.001233 1 0.41544 0.37919 0.4437 rs2151644 Imputed T DOM 679 0.527 0.2075 0.3509 0.7914 −3.088 0.002018 0.6758 0.10236 0.07358 0.125 rs2157752 Genotyped A GEN 682 12.46 0.001973 0.676 0.35557 0.30667 0.394 rs2158958 Imputed A DOM 682 0.56 0.1597 0.4098 0.7664 −3.626 0.000288 0.9329 0.34824 0.30833 0.3796 rs2158961 Imputed G DOM 680 0.564 0.1598 0.412 0.7707 −3.59 0.00033 0.9326 0.34706 0.30833 0.3776 rs2164099 Imputed G ADD 681 1.561 0.1254 1.221 1.995 3.551 0.000384 0.6918 0.26211 0.31 0.2244 rs2173254 Imputed G GEN 675 12.63 0.001808 0.08658 0.34074 0.29561 0.376 rs2173254 Imputed G REC 675 0.382 0.2927 0.2154 0.6786 −3.285 0.001021 0.08658 0.34074 0.29561 0.376 rs2188079 Imputed C ADD 682 1.482 0.1139 1.186 1.853 3.457 0.000547 0.8148 0.42962 0.48333 0.3874 rs2188079 Imputed C GEN 682 12.81 0.001651 0.8148 0.42962 0.48333 0.3874 rs2190304 Imputed G REC 682 0.439 0.2056 0.2933 0.6567 −4.005 6.20E−05 0.2503 0.47947 0.42667 0.5209 rs2190597 Imputed T DOM 681 0.559 0.174 0.3978 0.7868 −3.338 0.000844 0.9387 0.46916 0.43167 0.4987 rs2190598 Imputed T DOM 682 0.56 0.1597 0.4098 0.7664 −3.626 0.000288 0.9329 0.34824 0.30833 0.3796 rs2190600 Imputed A DOM 672 0.561 0.1605 0.4097 0.7686 −3.6 0.000319 0.9321 0.34598 0.3064 0.3773 rs2218084 Imputed T GEN 664 8.488 0.01435 0.02385 0.16416 0.18983 0.1436 rs2218084 Imputed T REC 664 3.657 0.4516 1.509 8.862 2.871 0.004092 0.02385 0.16416 0.18983 0.1436 rs2236290 Genotyped C GEN 680 6.499 0.0388 0.5618 0.36103 0.32667 0.3882 rs2243860 Imputed A GEN 548 9.796 0.00746 0.1582 0.40785 0.45021 0.3746 rs2243860 Imputed A REC 548 2.168 0.2486 1.332 3.529 3.113 0.00185 0.1582 0.40785 0.45021 0.3746 rs2246564 Imputed T DOM 682 0.529 0.2074 0.352 0.7937 −3.074 0.00211 0.6748 0.10191 0.07333 0.1243 rs2248236 Imputed C DOM 681 0.718 0.1608 0.524 0.9842 −2.059 0.03947 0.04865 0.20852 0.18833 0.2244 rs2250340 Imputed T DOM 600 0.514 0.2136 0.3382 0.7813 −3.115 0.001837 0.8378 0.1125 0.08113 0.1373 rs2257192 Imputed G DOM 682 0.529 0.2074 0.352 0.7937 −3.074 0.00211 0.6748 0.10191 0.07333 0.1243 rs2270584 Imputed A DOM 679 0.567 0.1632 0.4117 0.7806 −3.477 0.000507 0.7495 0.40059 0.36622 0.4276 rs2270586 Imputed A DOM 680 0.564 0.1631 0.4095 0.7761 −3.514 0.000442 0.8731 0.4 0.36622 0.4265 rs2270589 Imputed A ADD 682 0.711 0.1121 0.5703 0.8851 −3.048 0.002301 0.877 0.44648 0.40167 0.4817 rs2270589 Imputed A DOM 682 0.552 0.1689 0.3961 0.7679 −3.523 0.000426 0.877 0.44648 0.40167 0.4817 rs2270589 Imputed A GEN 682 12.43 0.001996 0.877 0.44648 0.40167 0.4817 rs2296889 Imputed C DOM 672 1.638 0.1743 1.164 2.305 2.832 0.004632 0.7651 0.15253 0.17508 0.1347 rs2301346 Imputed C ADD 550 1.573 0.133 1.212 2.042 3.407 0.000656 0.2216 0.29818 0.35124 0.2565 rs2301346 Imputed C DOM 550 1.763 0.1765 1.248 2.492 3.214 0.001311 0.2216 0.29818 0.35124 0.2565 rs2327929 Imputed G REC 682 2.122 0.1996 1.435 3.137 3.769 0.000164 0.09898 0.42155 0.47333 0.3809 rs2357486 Imputed C REC 673 2.717 0.2622 1.625 4.542 3.812 0.000138 0.7297 0.33432 0.37752 0.3 rs2373793 Imputed G DOM 646 1.534 0.1778 1.083 2.173 2.407 0.0161 0.1726 0.15402 0.18151 0.1314 rs2377622 Imputed T GEN 552 7.759 0.02066 0.9252 0.34692 0.3125 0.3719 rs2377622 Imputed T REC 552 0.437 0.2982 0.2436 0.784 −2.776 0.005501 0.9252 0.34692 0.3125 0.3719 rs2383903 Imputed G DOM 681 0.614 0.1576 0.4507 0.836 −3.096 0.001959 0.9247 0.28267 0.245 0.3123 rs2389866 Imputed C DOM 681 0.697 0.1612 0.508 0.9558 −2.24 0.02509 0.06186 0.20705 0.185 0.2244 rs2389869 Imputed C DOM 681 0.697 0.1612 0.508 0.9558 −2.24 0.02509 0.06186 0.20705 0.185 0.2244 rs2418541 Imputed A DOM 681 0.551 0.1595 0.4029 0.753 −3.738 0.000186 1 0.34802 0.30667 0.3806 rs2418542 Imputed A DOM 681 0.551 0.1595 0.4029 0.753 −3.738 0.000186 1 0.34802 0.30667 0.3806 rs2418548 Imputed C DOM 630 0.572 0.1639 0.4145 0.788 −3.414 0.00064 0.9279 0.32698 0.29474 0.3536 rs2476976 Imputed C DOM 681 1.728 0.1579 1.268 2.355 3.465 0.00053 0.855 0.29736 0.33278 0.2696 rs2483639 Imputed A DOM 682 0.529 0.2074 0.352 0.7937 −3.074 0.00211 0.6748 0.10191 0.07333 0.1243 rs2483640 Imputed A DOM 682 0.529 0.2074 0.352 0.7937 −3.074 0.00211 0.6748 0.10191 0.07333 0.1243 rs2544780 Imputed T REC 670 1.881 0.2505 1.151 3.073 2.521 0.0117 0.248 0.3194 0.35959 0.2884 rs2586458 Imputed T DOM 322 0.507 0.2771 0.2947 0.8733 −2.449 0.01433 0.4953 0.14286 0.10465 0.1684 rs2593272 Imputed G ADD 682 0.712 0.1296 0.5521 0.9177 −2.623 0.00872 0.6186 0.25953 0.225 0.2866 rs2593273 Imputed T ADD 678 0.699 0.1321 0.5396 0.9057 −2.71 0.006738 0.3627 0.25516 0.2198 0.2829 rs2622499 Imputed G DOM 682 0.726 0.1604 0.5299 0.9939 −1.998 0.04572 0.08586 0.21261 0.19333 0.2277 rs264126 Imputed C DOM 679 0.553 0.1744 0.3932 0.779 −3.392 0.000693 0.9386 0.46981 0.43167 0.5 rs264129 Imputed T DOM 681 0.561 0.1597 0.4104 0.7675 −3.617 0.000298 1 0.34802 0.30833 0.3793 rs2656822 Imputed T ADD 682 0.712 0.1296 0.5521 0.9177 −2.623 0.00872 0.6186 0.25953 0.225 0.2866 rs2656823 Imputed G ADD 682 0.712 0.1296 0.5521 0.9177 −2.623 0.00872 0.6186 0.25953 0.225 0.2866 rs2656825 Imputed T ADD 665 0.702 0.1338 0.5398 0.9119 −2.649 0.00807 0.4115 0.25263 0.21747 0.2802 rs2764766 Imputed C REC 678 1.803 0.2463 1.112 2.922 2.393 0.01673 0.2549 0.32448 0.36364 0.294 rs2793101 Imputed T ADD 680 0.506 0.1889 0.3491 0.732 −3.612 0.000304 1 0.1125 0.07833 0.1395 rs2793101 Imputed T DOM 680 0.501 0.2 0.3385 0.7413 −3.457 0.000547 1 0.1125 0.07833 0.1395 rs2795871 Imputed A ADD 676 0.578 0.2256 0.3717 0.9 −2.427 0.01522 0.3783 0.07175 0.05201 0.0873 rs2795886 Imputed A ADD 681 0.507 0.2747 0.2962 0.8693 −2.47 0.01352 0.0724 0.04919 0.03167 0.063 rs2795886 Imputed A DOM 681 0.517 0.2884 0.2939 0.9104 −2.285 0.02229 0.0724 0.04919 0.03167 0.063 rs2859994 Imputed C GEN 645 9.449 0.008877 0.112 0.37984 0.41986 0.3478 rs2870464 Imputed G DOM 682 1.534 0.1771 1.084 2.171 2.417 0.01564 0.5379 0.14443 0.17 0.1243 rs2875528 Imputed T DOM 682 1.705 0.2034 1.144 2.541 2.623 0.008711 0.3705 0.09457 0.11333 0.0798 rs2876227 Imputed C ADD 640 1.393 0.1179 1.106 1.755 2.811 0.00494 0.226 0.35156 0.39785 0.3158 rs2876227 Imputed C GEN 640 8.788 0.01235 0.226 0.35156 0.39785 0.3158 rs2882097 Imputed A DOM 682 1.772 0.1576 1.301 2.413 3.63 0.000284 1 0.29692 0.335 0.267 rs2921983 Imputed C ADD 640 0.679 0.1387 0.5173 0.8909 −2.793 0.00522 0.5889 0.23984 0.20285 0.2688 rs2987537 Imputed C DOM 682 0.501 0.1957 0.3413 0.735 −3.533 0.000411 0.2158 0.1239 0.09 0.1505 rs2996416 Imputed C ADD 682 0.518 0.1922 0.3551 0.7544 −3.426 0.000612 0.3055 0.10484 0.07167 0.1309 rs2996416 Imputed C DOM 682 0.474 0.2097 0.3145 0.7155 −3.556 0.000376 0.3055 0.10484 0.07167 0.1309 rs3015527 Imputed C ADD 677 0.519 0.1922 0.3558 0.7559 −3.416 0.000635 0.303 0.10487 0.07191 0.131 rs3015527 Imputed C DOM 677 0.476 0.2098 0.3154 0.7179 −3.54 0.000401 0.303 0.10487 0.07191 0.131 rs3015530 Imputed C ADD 682 0.518 0.1922 0.3551 0.7544 −3.426 0.000612 0.3055 0.10484 0.07167 0.1309 rs3015530 Imputed C DOM 682 0.474 0.2097 0.3145 0.7155 −3.556 0.000376 0.3055 0.10484 0.07167 0.1309 rs3015531 Imputed T ADD 682 0.518 0.1922 0.3551 0.7544 −3.426 0.000612 0.3055 0.10484 0.07167 0.1309 rs3015531 Imputed T DOM 682 0.474 0.2097 0.3145 0.7155 −3.556 0.000376 0.3055 0.10484 0.07167 0.1309 rs3015535 Imputed C ADD 682 0.518 0.1922 0.3551 0.7544 −3.426 0.000612 0.3055 0.10484 0.07167 0.1309 rs3015535 Imputed C DOM 682 0.474 0.2097 0.3145 0.7155 −3.556 0.000376 0.3055 0.10484 0.07167 0.1309 rs3019407 Imputed A GEN 675 12.63 0.001808 0.08658 0.34074 0.29561 0.376 rs3019407 Imputed A REC 675 0.382 0.2927 0.2154 0.6786 −3.285 0.001021 0.08658 0.34074 0.29561 0.376 rs36071725 Genotyped C GEN 682 15.36 0.000463 0.6072 0.33724 0.38333 0.301 rs373983 Imputed G DOM 661 1.911 0.1684 1.373 2.658 3.844 0.000121 0.4632 0.39334 0.44692 0.3509 rs3756154 Imputed C DOM 681 0.697 0.1612 0.508 0.9558 −2.24 0.02509 0.06186 0.20705 0.185 0.2244 rs3793044 Imputed C ADD 682 2.264 0.2373 1.422 3.606 3.444 0.000573 0.205 0.06598 0.09167 0.0458 rs3793044 Imputed C DOM 682 2.432 0.2521 1.484 3.986 3.525 0.000423 0.205 0.06598 0.09167 0.0458 rs3793053 Imputed C ADD 672 2.017 0.2117 1.332 3.055 3.316 0.000914 0.6256 0.08705 0.11409 0.0655 rs3793053 Imputed C DOM 672 2.188 0.2249 1.408 3.4 3.48 0.000501 0.6256 0.08705 0.11409 0.0655 rs3796246 Imputed G ADD 682 0.511 0.2045 0.3419 0.7623 −3.287 0.001012 1 0.09531 0.065 0.1191 rs3796246 Imputed G DOM 682 0.497 0.2139 0.3265 0.7551 −3.273 0.001063 1 0.09531 0.065 0.1191 rs3805996 Imputed G ADD 662 2.146 0.2358 1.352 3.407 3.239 0.001199 0.1442 0.07251 0.0976 0.0527 rs3805996 Imputed G DOM 662 2.368 0.2509 1.448 3.871 3.436 0.00059 0.1442 0.07251 0.0976 0.0527 rs3806003 Imputed A ADD 682 2.264 0.2373 1.422 3.606 3.444 0.000573 0.205 0.06598 0.09167 0.0458 rs3806003 Imputed A DOM 682 2.432 0.2521 1.484 3.986 3.525 0.000423 0.205 0.06598 0.09167 0.0458 rs3806004 Imputed T ADD 682 2.008 0.2082 1.336 3.02 3.35 0.000808 0.4997 0.09238 0.12 0.0707 rs3806004 Imputed T DOM 682 2.219 0.2217 1.437 3.427 3.596 0.000324 0.4997 0.09238 0.12 0.0707 rs3806010 Imputed T ADD 682 2.008 0.2082 1.336 3.02 3.35 0.000808 0.4997 0.09238 0.12 0.0707 rs3806010 Imputed T DOM 682 2.219 0.2217 1.437 3.427 3.596 0.000324 0.4997 0.09238 0.12 0.0707 rs3806014 Imputed T ADD 682 2.008 0.2082 1.336 3.02 3.35 0.000808 0.4997 0.09238 0.12 0.0707 rs3806014 Imputed T DOM 682 2.219 0.2217 1.437 3.427 3.596 0.000324 0.4997 0.09238 0.12 0.0707 rs3806015 Imputed A ADD 682 2.008 0.2082 1.336 3.02 3.35 0.000808 0.4997 0.09238 0.12 0.0707 rs3806015 Imputed A DOM 682 2.219 0.2217 1.437 3.427 3.596 0.000324 0.4997 0.09238 0.12 0.0707 rs3806018 Imputed A ADD 682 2.008 0.2082 1.336 3.02 3.35 0.000808 0.4997 0.09238 0.12 0.0707 rs3806018 Imputed A DOM 682 2.219 0.2217 1.437 3.427 3.596 0.000324 0.4997 0.09238 0.12 0.0707 rs3806019 Imputed A ADD 678 2.145 0.2126 1.414 3.253 3.588 0.000333 0.6198 0.08555 0.11538 0.062 rs3806019 Imputed A DOM 678 2.353 0.2258 1.511 3.663 3.788 0.000152 0.6198 0.08555 0.11538 0.062 rs3806024 Imputed T ADD 672 2.017 0.2117 1.332 3.055 3.316 0.000914 0.6256 0.08705 0.11409 0.0655 rs3806024 Imputed T DOM 672 2.188 0.2249 1.408 3.4 3.48 0.000501 0.6256 0.08705 0.11409 0.0655 rs3847825 Imputed G ADD 680 0.691 0.112 0.5544 0.8601 −3.305 0.00095 0.03311 0.37353 0.32107 0.4147 rs3847825 Imputed G GEN 680 11.36 0.003414 0.03311 0.37353 0.32107 0.4147 rs3852001 Genotyped C GEN 682 13.99 0.000919 0.07037 0.19721 0.24167 0.1623 rs3852001 Genotyped C REC 682 4.254 0.4136 1.891 9.569 3.5 0.000465 0.07037 0.19721 0.24167 0.1623 rs3852002 Imputed G GEN 681 13.41 0.001226 0.08816 0.1953 0.23913 0.161 rs3852002 Imputed G REC 681 4.089 0.4152 1.812 9.226 3.392 0.000694 0.08816 0.1953 0.23913 0.161 rs3852003 Imputed A GEN 681 13.41 0.001226 0.08816 0.1953 0.23913 0.161 rs3852003 Imputed A REC 681 4.089 0.4152 1.812 9.226 3.392 0.000694 0.08816 0.1953 0.23913 0.161 rs3942254 Imputed T DOM 678 0.6 0.1651 0.4341 0.8292 −3.094 0.001974 1 0.40413 0.37037 0.4304 rs3945085 Imputed A DOM 682 1.794 0.1572 1.319 2.442 3.72 0.000199 1 0.29252 0.33167 0.2618 rs399485 Imputed A DOM 678 1.537 0.1571 1.129 2.091 2.735 0.006241 0.697 0.26917 0.30705 0.2395 rs4029119 Imputed G ADD 682 0.217 0.4129 0.0965 0.4867 −3.704 0.000213 0.06816 0.03812 0.01667 0.055 rs4029119 Imputed G DOM 682 0.223 0.4255 0.0967 0.5123 −3.532 0.000412 0.06816 0.03812 0.01667 0.055 rs412791 Imputed C GEN 675 12.74 0.001714 0.8702 0.38 0.33054 0.4191 rs4146972 Genotyped T DOM 682 1.42 0.1657 1.026 1.965 2.117 0.0343 0.6059 0.18035 0.19833 0.1662 rs4259369 Imputed C REC 679 0.645 0.1981 0.4374 0.9509 −2.214 0.02681 0.01503 0.42636 0.40468 0.4434 rs4273613 Imputed T ADD 682 0.217 0.4129 0.0965 0.4867 −3.704 0.000213 0.06816 0.03812 0.01667 0.055 rs4273613 Imputed T DOM 682 0.223 0.4255 0.0967 0.5123 −3.532 0.000412 0.06816 0.03812 0.01667 0.055 rs4294022 Imputed C DOM 659 0.632 0.1627 0.4591 0.8687 −2.825 0.004728 1 0.23293 0.19792 0.2601 rs4310554 Genotyped C DOM 682 1.747 0.1888 1.207 2.53 2.956 0.00312 0.2203 0.49707 0.54167 0.462 rs4315598 Imputed T ADD 682 1.338 0.1141 1.07 1.674 2.555 0.01063 0.2786 0.35777 0.39667 0.3272 rs4315598 Imputed T GEN 682 7.867 0.01957 0.2786 0.35777 0.39667 0.3272 rs4370878 Imputed G DOM 682 1.755 0.157 1.29 2.388 3.583 0.00034 0.9265 0.29399 0.33167 0.2644 rs4436200 Imputed C ADD 682 0.718 0.169 0.5154 0.9996 −1.963 0.0497 0.2391 0.1305 0.11 0.1466 rs4444612 Imputed G ADD 682 1.338 0.1141 1.07 1.674 2.555 0.01063 0.2786 0.35777 0.39667 0.3272 rs4444612 Imputed G GEN 682 7.867 0.01957 0.2786 0.35777 0.39667 0.3272 rs4450660 Imputed C DOM 675 1.654 0.1588 1.212 2.258 3.168 0.001533 0.07497 0.24296 0.27778 0.2156 rs4463950 Imputed C DOM 671 0.617 0.1688 0.4431 0.8588 −2.862 0.004214 0.9374 0.43294 0.40541 0.4547 rs4509702 Imputed C DOM 682 1.755 0.157 1.29 2.388 3.583 0.00034 0.9265 0.29399 0.33167 0.2644 rs4533379 Imputed G ADD 681 1.561 0.1254 1.221 1.995 3.551 0.000384 0.6918 0.26211 0.31 0.2244 rs4569984 Imputed A DOM 671 0.645 0.1612 0.4706 0.8853 −2.715 0.006623 0.8278 0.231 0.19661 0.258 rs4570530 Imputed C DOM 681 1.766 0.1571 1.298 2.403 3.62 0.000295 0.9266 0.29369 0.33167 0.2638 rs4571583 Imputed T DOM 666 0.645 0.162 0.4697 0.8862 −2.706 0.006814 0.9134 0.23123 0.19759 0.2573 rs4586678 Imputed A DOM 678 1.637 0.1582 1.2 2.232 3.114 0.001843 0.07807 0.24484 0.27852 0.2184 rs4615971 Imputed C DOM 676 1.8 0.1582 1.32 2.455 3.716 0.000202 0.9269 0.29734 0.33784 0.2658 rs4629229 Imputed G DOM 682 0.521 0.1725 0.3715 0.7305 −3.78 0.000157 0.4294 0.17595 0.13667 0.2068 rs4632512 Imputed T GEN 681 13.12 0.001413 0.1414 0.19457 0.23833 0.1601 rs4641552 Imputed A ADD 678 0.514 0.2311 0.3271 0.8092 −2.876 0.004025 0.7689 0.07153 0.04849 0.0897 rs4682527 Imputed C DOM 656 1.64 0.1669 1.183 2.275 2.966 0.003017 0.3618 0.37805 0.40941 0.3537 rs4688632 Imputed G REC 675 0.538 0.1943 0.3678 0.7876 −3.189 0.001429 0.3557 0.48889 0.45424 0.5158 rs4702720 Imputed A ADD 530 0.596 0.1535 0.4412 0.8051 −3.372 0.000745 0.08183 0.22547 0.17842 0.2647 rs4702720 Imputed A DOM 530 0.541 0.1863 0.3758 0.7798 −3.295 0.000984 0.08183 0.22547 0.17842 0.2647 rs4714484 Imputed A ADD 681 0.631 0.1545 0.4661 0.8539 −2.982 0.002861 0.8896 0.1652 0.13 0.1929 rs4714484 Imputed A DOM 681 0.606 0.1733 0.4315 0.8511 −2.89 0.003849 0.8896 0.1652 0.13 0.1929 rs4725142 Genotyped G REC 682 0.444 0.2656 0.2639 0.7476 −3.055 0.002251 0.2804 0.3585 0.33667 0.3757 rs4725144 Imputed G REC 677 0.427 0.2722 0.2502 0.7275 −3.129 0.001756 0.2734 0.35229 0.32886 0.3707 rs4760785 Imputed A ADD 657 0.709 0.1165 0.5639 0.8903 −2.957 0.003102 0.5823 0.45282 0.41003 0.4864 rs4760785 Imputed A DOM 657 0.595 0.1749 0.4222 0.8382 −2.969 0.002989 0.5823 0.45282 0.41003 0.4864 rs4760894 Imputed T ADD 657 0.709 0.1165 0.5639 0.8903 −2.957 0.003102 0.5823 0.45282 0.41003 0.4864 rs4760894 Imputed T DOM 657 0.595 0.1749 0.4222 0.8382 −2.969 0.002989 0.5823 0.45282 0.41003 0.4864 rs4760895 Imputed A ADD 657 0.709 0.1165 0.5639 0.8903 −2.957 0.003102 0.5823 0.45282 0.41003 0.4864 rs4760895 Imputed A DOM 657 0.595 0.1749 0.4222 0.8382 −2.969 0.002989 0.5823 0.45282 0.41003 0.4864 rs4767184 Imputed C ADD 678 0.704 0.1112 0.5659 0.8752 −3.159 0.001584 0.02822 0.38127 0.3311 0.4208 rs4767184 Imputed C GEN 678 9.99 0.006772 0.02822 0.38127 0.3311 0.4208 rs4773487 Imputed T ADD 682 0.555 0.1837 0.3871 0.7953 −3.207 0.001342 0.2503 0.11364 0.08167 0.1387 rs4780547 Imputed G GEN 682 8.214 0.01646 0.1488 0.22141 0.19167 0.2448 rs4780547 Imputed G REC 682 0.327 0.3979 0.1501 0.7141 −2.806 0.005013 0.1488 0.22141 0.19167 0.2448 rs483159 Imputed T DOM 611 1.742 0.1718 1.244 2.44 3.23 0.001236 0.899 0.19722 0.23432 0.1676 rs4836502 Imputed T DOM 682 0.56 0.1597 0.4098 0.7664 −3.626 0.000288 0.9329 0.34824 0.30833 0.3796 rs4836507 Imputed C DOM 672 0.561 0.1605 0.4097 0.7686 −3.6 0.000319 0.9321 0.34598 0.3064 0.3773 rs4851531 Imputed T DOM 677 0.722 0.1629 0.5246 0.9935 −2 0.0455 1 0.4062 0.37584 0.4301 rs4879931 Imputed G ADD 678 0.672 0.1211 0.5303 0.8526 −3.277 0.00105 0.2044 0.30457 0.25758 0.3412 rs489441 Imputed G ADD 631 1.549 0.1342 1.191 2.015 3.261 0.00111 0.4702 0.2607 0.30545 0.2261 rs489441 Imputed G DOM 631 1.778 0.164 1.289 2.452 3.509 0.00045 0.4702 0.2607 0.30545 0.2261 rs4976276 Imputed T ADD 681 1.45 0.125 1.135 1.853 2.973 0.002945 0.07074 0.3047 0.345 0.273 rs4977681 Imputed C REC 682 2.487 0.278 1.442 4.288 3.278 0.001047 0.7153 0.29912 0.33 0.2749 rs4986197 Imputed G ADD 679 1.564 0.1255 1.223 2 3.563 0.000366 0.6211 0.26215 0.3104 0.2244 rs4986220 Imputed T ADD 681 1.538 0.1266 1.2 1.971 3.4 0.000673 0.8411 0.25698 0.30268 0.2212 rs525462 Imputed A GEN 682 4.513 0.1047 0.1205 0.56012 0.53 0.5838 rs552006 Imputed G GEN 678 9.189 0.01011 0.00901 0.2913 0.32886 0.2618 rs5756669 Imputed C DOM 679 1.798 0.1769 1.271 2.543 3.316 0.000914 1 0.45582 0.49664 0.4239 rs581905 Imputed T DOM 681 1.742 0.218 1.137 2.671 2.548 0.01085 1 0.08003 0.10167 0.063 rs6033138 Imputed C ADD 682 1.338 0.1141 1.07 1.674 2.555 0.01063 0.2786 0.35777 0.39667 0.3272 rs6033138 Imputed C GEN 682 7.867 0.01957 0.2786 0.35777 0.39667 0.3272 rs6040619 Imputed C ADD 677 1.341 0.1132 1.074 1.675 2.594 0.009478 0.2114 0.36115 0.40101 0.3298 rs6040619 Imputed C GEN 677 7.963 0.01866 0.2114 0.36115 0.40101 0.3298 rs6040625 Imputed T ADD 680 1.351 0.1131 1.082 1.686 2.66 0.007824 0.2138 0.36103 0.40167 0.3289 rs6040625 Imputed T GEN 680 8.078 0.01761 0.2138 0.36103 0.40167 0.3289 rs6040630 Imputed A ADD 679 1.356 0.1137 1.085 1.694 2.676 0.007453 0.317 0.35935 0.4 0.3272 rs6040630 Imputed A GEN 679 8.108 0.01735 0.317 0.35935 0.4 0.3272 rs6040633 Imputed A ADD 679 1.356 0.1137 1.085 1.694 2.676 0.007453 0.317 0.35935 0.4 0.3272 rs6040633 Imputed A GEN 679 8.108 0.01735 0.317 0.35935 0.4 0.3272 rs6040634 Imputed T ADD 682 1.306 0.1123 1.048 1.628 2.378 0.01743 0.2463 0.3629 0.4 0.3338 rs6040634 Imputed T GEN 682 6.36 0.0416 0.2463 0.3629 0.4 0.3338 rs6040636 Imputed T ADD 681 1.312 0.1124 1.052 1.635 2.413 0.01583 0.2147 0.3627 0.4 0.3333 rs6040636 Imputed T GEN 681 6.462 0.03952 0.2147 0.3627 0.4 0.3333 rs6040638 Imputed C ADD 682 1.338 0.1141 1.07 1.674 2.555 0.01063 0.2786 0.35777 0.39667 0.3272 rs6040638 Imputed C GEN 682 7.867 0.01957 0.2786 0.35777 0.39667 0.3272 rs6040644 Imputed A ADD 680 1.338 0.1141 1.07 1.674 2.554 0.01065 0.2795 0.35882 0.39799 0.3281 rs6040644 Imputed A GEN 680 7.863 0.01962 0.2795 0.35882 0.39799 0.3281 rs6040667 Imputed T ADD 669 1.394 0.1165 1.11 1.752 2.853 0.004333 0.3047 0.34529 0.38908 0.3112 rs6040667 Imputed T GEN 669 8.924 0.01154 0.3047 0.34529 0.38908 0.3112 rs6040668 Imputed C ADD 669 1.394 0.1165 1.11 1.752 2.853 0.004333 0.3047 0.34529 0.38908 0.3112 rs6040668 Imputed C GEN 669 8.924 0.01154 0.3047 0.34529 0.38908 0.3112 rs6053005 Imputed C DOM 479 0.644 0.2558 0.3901 1.063 −1.72 0.08545 0.7029 0.60334 0.59709 0.6081 rs6054405 Imputed A REC 679 2.249 0.2226 1.454 3.478 3.641 0.000271 0.6876 0.39323 0.44631 0.3517 rs6054427 Genotyped G GEN 682 12.27 0.002167 0.4728 0.39736 0.44667 0.3586 rs6075186 Imputed G DOM 682 0.521 0.1725 0.3715 0.7305 −3.78 0.000157 0.4294 0.17595 0.13667 0.2068 rs608278 Imputed A ADD 594 0.702 0.1219 0.5527 0.8913 −2.904 0.003681 0.8663 0.41835 0.37354 0.4525 rs6111540 Imputed A ADD 630 0.643 0.1186 0.5094 0.8109 −3.727 0.000194 0.8731 0.47619 0.41455 0.5239 rs6131206 Imputed C ADD 668 1.277 0.1203 1.009 1.617 2.033 0.04201 0.3108 0.29865 0.3299 0.2745 rs6131208 Imputed T ADD 669 1.394 0.1165 1.11 1.752 2.853 0.004333 0.3047 0.34529 0.38908 0.3112 rs6131208 Imputed T GEN 669 8.924 0.01154 0.3047 0.34529 0.38908 0.3112 rs6131919 Imputed G DOM 682 0.521 0.1725 0.3715 0.7305 −3.78 0.000157 0.4294 0.17595 0.13667 0.2068 rs6134243 Imputed C ADD 682 1.338 0.1141 1.07 1.674 2.555 0.01063 0.2786 0.35777 0.39667 0.3272 rs6134243 Imputed C GEN 682 7.867 0.01957 0.2786 0.35777 0.39667 0.3272 rs6136020 Imputed A DOM 681 0.511 0.1731 0.3638 0.7171 −3.881 0.000104 0.4267 0.17548 0.13545 0.2068 rs613799 Imputed C DOM 582 1.79 0.1709 1.28 2.502 3.405 0.000663 1 0.28866 0.32738 0.2591 rs644041 Imputed G ADD 621 1.565 0.135 1.201 2.039 3.319 0.000902 0.4688 0.26329 0.30882 0.2278 rs644041 Imputed G DOM 621 1.762 0.165 1.275 2.435 3.433 0.000597 0.4688 0.26329 0.30882 0.2278 rs6464377 Imputed C DOM 681 2.223 0.2258 1.428 3.46 3.538 0.000404 0.5678 0.07269 0.09833 0.0525 rs6474230 Imputed T DOM 681 1.542 0.1596 1.127 2.108 2.712 0.006696 0.106 0.23128 0.25585 0.212 rs6476565 Imputed A DOM 677 0.524 0.2092 0.3479 0.7901 −3.086 0.00203 0.6704 0.10118 0.07239 0.1237 rs6511286 Imputed T ADD 675 1.359 0.1178 1.079 1.712 2.603 0.009243 0.5353 0.31852 0.3557 0.2891 rs6541829 Genotyped C REC 682 1.978 0.3119 1.073 3.646 2.187 0.02875 0.9213 0.2632 0.28833 0.2435 rs6544721 Imputed G DOM 675 1.623 0.1588 1.189 2.216 3.049 0.002295 0.05817 0.24148 0.27458 0.2158 rs6544728 Imputed T DOM 680 1.638 0.158 1.202 2.233 3.124 0.001785 0.03564 0.23971 0.27592 0.2113 rs6565910 Imputed G DOM 675 0.576 0.1625 0.4188 0.7919 −3.395 0.000685 0.1512 0.24963 0.21044 0.2804 rs6581985 Imputed G GEN 661 8.243 0.01622 0.7098 0.29728 0.32646 0.2743 rs6581985 Imputed G REC 661 2.29 0.2899 1.298 4.042 2.859 0.004255 0.7098 0.29728 0.32646 0.2743 rs6685186 Imputed T ADD 680 1.508 0.1138 1.206 1.884 3.606 0.000312 0.9363 0.39926 0.45485 0.3556 rs6685186 Imputed T GEN 680 13.11 0.001423 0.9363 0.39926 0.45485 0.3556 rs670593 Imputed A REC 678 0.594 0.2258 0.3815 0.9244 −2.308 0.02099 0.8731 0.40192 0.38629 0.4142 rs6722640 Imputed T DOM 682 0.696 0.1624 0.5059 0.9562 −2.236 0.02536 0.7521 0.40909 0.37833 0.4332 rs6746170 Imputed A DOM 679 1.647 0.1581 1.208 2.245 3.155 0.001604 0.03549 0.24006 0.27685 0.2113 rs6757316 Imputed A GEN 675 12.53 0.001901 0.4778 0.42222 0.46633 0.3876 rs6805139 Imputed G DOM 681 1.829 0.1922 1.255 2.666 3.141 0.001685 0.4904 0.51101 0.54333 0.4856 rs6808571 Imputed G ADD 675 1.794 0.1564 1.32 2.438 3.736 0.000187 0.5429 0.14889 0.19231 0.1144 rs6816479 Imputed A REC 681 1.903 0.2298 1.213 2.985 2.8 0.005116 0.4521 0.35609 0.36789 0.3469 rs6865976 Imputed C DOM 636 0.514 0.1832 0.3586 0.7355 −3.636 0.000277 0.5254 0.47799 0.42419 0.5195 rs687047 Imputed C ADD 682 0.621 0.1734 0.4423 0.8729 −2.744 0.00607 0.485 0.1261 0.09833 0.1479 rs6871041 Imputed G DOM 625 0.549 0.1652 0.3974 0.7594 −3.626 0.000288 0.7819 0.3176 0.27957 0.3483 rs688358 Imputed A ADD 672 0.627 0.1736 0.4457 0.8804 −2.693 0.007071 0.4853 0.12723 0.09966 0.1489 rs6908481 Imputed C REC 664 2.09 0.2119 1.38 3.166 3.479 0.000503 0.1953 0.39759 0.44138 0.3636 rs6917224 Imputed A ADD 682 1.452 0.1114 1.167 1.806 3.346 0.000821 0.3803 0.40029 0.45167 0.3599 rs6917224 Imputed A GEN 682 11.22 0.003661 0.3803 0.40029 0.45167 0.3599 rs6920677 Imputed G DOM 669 0.657 0.1616 0.4785 0.9016 −2.601 0.009294 0.5131 0.38266 0.3468 0.4113 rs6994498 Imputed G DOM 679 1.535 0.1598 1.122 2.1 2.682 0.007325 0.1286 0.22975 0.25336 0.2113 rs6998772 Imputed T DOM 682 2.585 0.2693 1.525 4.383 3.526 0.000422 0.1493 0.05572 0.07833 0.038 rs7022281 Imputed C ADD 678 0.736 0.1153 0.5872 0.9228 −2.656 0.007896 0.8713 0.38569 0.34783 0.4156 rs7022281 Imputed C GEN 678 7.862 0.01963 0.8713 0.38569 0.34783 0.4156 rs7022281 Imputed C REC 678 0.551 0.2295 0.3514 0.864 −2.597 0.009407 0.8713 0.38569 0.34783 0.4156 rs7043983 Imputed T DOM 678 0.526 0.2092 0.3491 0.7928 −3.07 0.00214 0.6702 0.10103 0.07239 0.1234 rs7077799 Imputed A DOM 682 1.772 0.1576 1.301 2.413 3.63 0.000284 1 0.29692 0.335 0.267 rs7088947 Imputed A ADD 681 0.579 0.2256 0.372 0.9006 −2.424 0.01536 0.3761 0.07122 0.05167 0.0866 rs7089661 Imputed C DOM 682 1.786 0.1574 1.312 2.431 3.685 0.000229 1 0.29545 0.335 0.2644 rs7102072 Imputed A DOM 681 0.569 0.1579 0.4177 0.7758 −3.568 0.00036 0.397 0.28488 0.24167 0.3189 rs710832 Genotyped A REC 682 0.39 0.3429 0.1992 0.7638 −2.746 0.006038 0.2666 0.25293 0.24 0.2631 rs712531 Imputed A DOM 671 1.679 0.1639 1.217 2.315 3.16 0.001579 0.2799 0.36587 0.39691 0.3421 rs7129817 Imputed T ADD 674 0.693 0.1168 0.5509 0.8706 −3.147 0.001649 0.4978 0.34866 0.30201 0.3856 rs7134262 Imputed T GEN 678 19.92 4.72E−05 0.9333 0.35619 0.3796 0.3377 rs7134262 Imputed T REC 678 2.671 0.2439 1.656 4.308 4.027 5.66E−05 0.9333 0.35619 0.3796 0.3377 rs7138300 Imputed C ADD 657 0.709 0.1165 0.5639 0.8903 −2.957 0.003102 0.5823 0.45282 0.41003 0.4864 rs7138300 Imputed C DOM 657 0.595 0.1749 0.4222 0.8382 −2.969 0.002989 0.5823 0.45282 0.41003 0.4864 rs722927 Imputed G ADD 660 0.494 0.2288 0.3152 0.773 −3.085 0.002035 0.2612 0.07652 0.04915 0.0986 rs722927 Imputed G DOM 660 0.474 0.2419 0.2951 0.7616 −3.086 0.002029 0.2612 0.07652 0.04915 0.0986 rs726424 Genotyped G ADD 682 0.709 0.111 0.57 0.8809 −3.102 0.001922 0.02768 0.37757 0.32833 0.4162 rs726424 Genotyped G GEN 682 10.03 0.006653 0.02768 0.37757 0.32833 0.4162 rs7295817 Imputed C ADD 677 0.667 0.1118 0.5356 0.8302 −3.624 0.00029 0.0658 0.40177 0.34343 0.4474 rs7295817 Imputed C GEN 677 13.77 0.001022 0.0658 0.40177 0.34343 0.4474 rs7295817 Imputed C REC 677 0.482 0.218 0.3144 0.739 −3.347 0.000816 0.0658 0.40177 0.34343 0.4474 rs7297372 Imputed A ADD 682 0.69 0.1134 0.5524 0.8617 −3.272 0.001068 0.8151 0.56891 0.52 0.6073 rs7297372 Imputed A GEN 682 10.73 0.00468 0.8151 0.56891 0.52 0.6073 rs7298255 Imputed A ADD 682 0.725 0.1134 0.5804 0.9053 −2.837 0.004558 0.701 0.46701 0.42667 0.4987 rs7298255 Imputed A DOM 682 0.584 0.1737 0.4156 0.8211 −3.095 0.001971 0.701 0.46701 0.42667 0.4987 rs7305832 Imputed C GEN 678 19.92 4.72E−05 0.9333 0.35619 0.3796 0.3377 rs7305832 Imputed C REC 678 2.671 0.2439 1.656 4.308 4.027 5.66E−05 0.9333 0.35619 0.3796 0.3377 rs737542 Imputed A REC 678 1.983 0.312 1.076 3.655 2.194 0.02823 0.8432 0.26327 0.28859 0.2434 rs742827 Imputed A ADD 637 1.408 0.1178 1.118 1.774 2.905 0.003678 0.2603 0.35479 0.40108 0.3189 rs742827 Imputed A GEN 637 8.971 0.01127 0.2603 0.35479 0.40108 0.3189 rs7446891 Imputed G DOM 681 0.561 0.1597 0.4104 0.7675 −3.617 0.000298 0.9326 0.34728 0.30833 0.378 rs7448641 Imputed C ADD 682 0.187 0.4378 0.0793 0.441 −3.83 0.000128 0.06181 0.03739 0.015 0.055 rs7448641 Imputed C DOM 682 0.19 0.451 0.0786 0.4606 −3.679 0.000234 0.06181 0.03739 0.015 0.055 rs7460605 Imputed G DOM 638 1.639 0.1689 1.177 2.283 2.927 0.003421 0.1625 0.40282 0.43816 0.3746 rs7468898 Imputed T ADD 674 1.412 0.1152 1.127 1.77 2.995 0.002747 0.3143 0.45846 0.50334 0.4227 rs7468898 Imputed T GEN 674 9.55 0.008438 0.3143 0.45846 0.50334 0.4227 rs7501186 Imputed A DOM 677 1.561 0.1787 1.099 2.215 2.49 0.01276 0.5241 0.13959 0.16498 0.1197 rs755117 Imputed A DOM 651 1.658 0.1686 1.192 2.308 2.999 0.002709 0.3232 0.19662 0.22664 0.1727 rs7557560 Imputed T GEN 679 8.554 0.01389 0.9031 0.19514 0.21906 0.1763 rs7557560 Imputed T REC 679 3.783 0.4649 1.521 9.41 2.862 0.004208 0.9031 0.19514 0.21906 0.1763 rs7562462 Imputed T DOM 673 1.896 0.1733 1.35 2.662 3.691 0.000223 0.2091 0.43388 0.48294 0.3961 rs757173 Genotyped G DOM 682 0.544 0.1595 0.398 0.7436 −3.817 0.000135 1 0.36217 0.31 0.4031 rs7607447 Imputed T REC 676 1.87 0.2836 1.073 3.26 2.208 0.02726 0.7777 0.28624 0.29798 0.277 rs7639053 Imputed A ADD 682 1.506 0.1344 1.157 1.96 3.046 0.002322 0.9093 0.21408 0.25167 0.1846 rs7648163 Imputed C REC 654 1.993 0.25 1.221 3.252 2.758 0.005822 0.3754 0.32875 0.34896 0.3128 rs7651273 Imputed A GEN 680 14.12 0.00086 0.08957 0.19779 0.24247 0.1627 rs7653190 Imputed C ADD 677 1.504 0.1347 1.155 1.958 3.029 0.002453 0.9092 0.21492 0.25253 0.1855 rs7653685 Genotyped C DOM 682 1.705 0.2034 1.144 2.541 2.623 0.008711 0.3705 0.09457 0.11333 0.0798 rs7684899 Imputed C DOM 682 0.713 0.1608 0.5205 0.9774 −2.102 0.03551 0.04848 0.20894 0.18833 0.2251 rs7701604 Imputed G ADD 682 0.187 0.4378 0.0793 0.441 −3.83 0.000128 0.06181 0.03739 0.015 0.055 rs7701604 Imputed G DOM 682 0.19 0.451 0.0786 0.4606 −3.679 0.000234 0.06181 0.03739 0.015 0.055 rs7703676 Imputed C ADD 682 0.187 0.4378 0.0793 0.441 −3.83 0.000128 0.06181 0.03739 0.015 0.055 rs7703676 Imputed C DOM 682 0.19 0.451 0.0786 0.4606 −3.679 0.000234 0.06181 0.03739 0.015 0.055 rs7711358 Imputed A DOM 677 0.564 0.1602 0.4123 0.7725 −3.571 0.000355 1 0.34934 0.30976 0.3803 rs7713251 Imputed C REC 661 2.098 0.2572 1.267 3.474 2.882 0.003956 0.6634 0.33661 0.37075 0.3093 rs7737608 Imputed G DOM 676 1.904 0.164 1.38 2.625 3.926 8.65E−05 0.5601 0.36169 0.41186 0.3228 rs7755903 Imputed A GEN 681 7.188 0.02748 0.9377 0.42805 0.38833 0.4593 rs7762993 Imputed A ADD 677 1.726 0.1392 1.314 2.268 3.921 8.82E−05 0.219 0.19276 0.24074 0.1553 rs7762993 Imputed A DOM 677 2.011 0.1659 1.453 2.784 4.21 2.55E−05 0.219 0.19276 0.24074 0.1553 rs7767265 Imputed G DOM 663 2.106 0.1643 1.526 2.905 4.533 5.81E−06 0.07386 0.22323 0.27875 0.1809 rs7769415 Imputed C GEN 670 4.537 0.1035 0.9297 0.32239 0.34694 0.3032 rs7771264 Imputed T DOM 654 0.635 0.1631 0.4613 0.8744 −2.783 0.005385 1 0.23471 0.2 0.2615 rs7795792 Imputed T REC 679 0.645 0.1981 0.4374 0.9509 −2.214 0.02681 0.01503 0.42636 0.40468 0.4434 rs7806481 Imputed G REC 682 0.439 0.2056 0.2933 0.6567 −4.005 6.20E−05 0.2503 0.47947 0.42667 0.5209 rs7808536 Imputed G DOM 678 1.455 0.1608 1.062 1.995 2.334 0.01962 0.7257 0.20649 0.2291 0.1887 rs7814819 Imputed G ADD 395 2.408 0.2698 1.419 4.086 3.256 0.001129 1 0.08734 0.12431 0.0561 rs7814819 Imputed G DOM 395 2.577 0.2831 1.48 4.488 3.345 0.000824 1 0.08734 0.12431 0.0561 rs7815952 Imputed T DOM 682 2.585 0.2693 1.525 4.383 3.526 0.000422 0.1493 0.05572 0.07833 0.038 rs7834090 Imputed T DOM 682 2.585 0.2693 1.525 4.383 3.526 0.000422 0.1493 0.05572 0.07833 0.038 rs7859250 Imputed C DOM 679 0.52 0.2089 0.345 0.7824 −3.134 0.001722 0.6726 0.10162 0.07239 0.1243 rs7863577 Genotyped A ADD 682 0.48 0.201 0.3239 0.7122 −3.648 0.000264 0.6823 0.10337 0.07 0.1296 rs7863577 Genotyped A DOM 682 0.479 0.2131 0.3153 0.7268 −3.458 0.000545 0.6823 0.10337 0.07 0.1296 rs7902140 Imputed C ADD 673 0.63 0.1425 0.4765 0.8328 −3.244 0.001178 0.1401 0.19539 0.1532 0.2287 rs7921834 Imputed C DOM 682 1.786 0.1574 1.312 2.431 3.685 0.000229 1 0.29545 0.335 0.2644 rs7939893 Imputed C ADD 682 0.707 0.1129 0.5669 0.8826 −3.066 0.002167 0.005005 0.34311 0.29833 0.3783 rs7939893 Imputed C DOM 682 0.641 0.1573 0.4706 0.8718 −2.832 0.004625 0.005005 0.34311 0.29833 0.3783 rs7955901 Imputed C ADD 675 0.723 0.1135 0.579 0.9035 −2.855 0.00431 0.8771 0.46741 0.42617 0.5 rs7955901 Imputed C DOM 675 0.582 0.1743 0.4133 0.8183 −3.11 0.001869 0.8771 0.46741 0.42617 0.5 rs7956274 Imputed T ADD 677 0.74 0.1141 0.5915 0.9251 −2.642 0.00823 0.6995 0.4675 0.42929 0.4974 rs7956274 Imputed T DOM 677 0.598 0.1747 0.4246 0.8421 −2.944 0.003242 0.6995 0.4675 0.42929 0.4974 rs7957932 Imputed G ADD 671 0.738 0.1147 0.5895 0.9243 −2.646 0.008151 0.6433 0.47615 0.4375 0.5067 rs7957932 Imputed G DOM 671 0.57 0.1775 0.4021 0.8065 −3.171 0.001518 0.6433 0.47615 0.4375 0.5067 rs7984294 Imputed A DOM 678 1.497 0.19 1.032 2.173 2.125 0.03361 0.8479 0.11283 0.13255 0.0974 rs7994286 Imputed A ADD 674 0.538 0.1883 0.3721 0.7784 −3.29 0.001 0.2388 0.10979 0.07653 0.1355 rs7994286 Imputed A DOM 674 0.5 0.2066 0.3333 0.7491 −3.358 0.000784 0.2388 0.10979 0.07653 0.1355 rs8038229 Genotyped A ADD 682 0.809 0.1191 0.6403 1.021 −1.783 0.07457 0.2326 0.29545 0.26833 0.3168 rs8038229 Genotyped A DOM 682 0.742 0.1556 0.547 1.007 −1.918 0.05517 0.2326 0.29545 0.26833 0.3168 rs8043336 Imputed C GEN 647 8.706 0.01287 0.9305 0.34312 0.30851 0.3699 rs8043336 Imputed C REC 647 0.449 0.2712 0.264 0.7645 −2.95 0.003176 0.9305 0.34312 0.30851 0.3699 rs8054431 Imputed T DOM 652 1.625 0.1667 1.172 2.253 2.915 0.003561 0.5067 0.38037 0.41434 0.3538 rs8066502 Imputed T DOM 681 0.683 0.1787 0.4814 0.9701 −2.13 0.03319 1 0.14317 0.12667 0.1562 rs8068714 Imputed T DOM 682 0.671 0.1793 0.4725 0.954 −2.223 0.02623 0.8763 0.14223 0.125 0.1558 rs892575 Imputed T ADD 681 1.549 0.1262 1.21 1.984 3.471 0.000519 0.7644 0.25844 0.305 0.2218 rs892583 Imputed G ADD 679 1.541 0.1267 1.202 1.976 3.414 0.00064 0.9202 0.25847 0.30435 0.2224 rs915494 Imputed A ADD 647 1.548 0.1295 1.201 1.995 3.374 0.00074 0.6962 0.27975 0.32517 0.2438 rs915494 Imputed A DOM 647 1.881 0.1622 1.369 2.585 3.896 9.77E−05 0.6962 0.27975 0.32517 0.2438 rs917295 Imputed G DOM 681 0.561 0.1597 0.4104 0.7675 −3.617 0.000298 0.9326 0.34728 0.30833 0.378 rs922594 Imputed T DOM 681 0.735 0.1583 0.5392 1.003 −1.941 0.05228 0.1829 0.35756 0.34281 0.3691 rs9301653 Imputed T ADD 682 0.518 0.1922 0.3551 0.7544 −3.426 0.000612 0.3055 0.10484 0.07167 0.1309 rs9301653 Imputed T DOM 682 0.474 0.2097 0.3145 0.7155 −3.556 0.000376 0.3055 0.10484 0.07167 0.1309 rs9309988 Imputed G DOM 682 1.705 0.2034 1.144 2.541 2.623 0.008711 0.3705 0.09457 0.11333 0.0798 rs9309989 Genotyped C DOM 682 1.731 0.2018 1.165 2.57 2.718 0.006576 0.1323 0.09824 0.11667 0.0838 rs9310221 Imputed A DOM 631 2.083 0.1765 1.474 2.943 4.157 3.23E−05 0.6253 0.42155 0.46277 0.3883 rs9327555 Imputed T DOM 682 0.56 0.1597 0.4098 0.7664 −3.626 0.000288 0.866 0.34751 0.30833 0.3783 rs937890 Imputed G DOM 638 0.654 0.1848 0.455 0.939 −2.3 0.02143 0.8728 0.14498 0.12633 0.1597 rs9454967 Imputed G ADD 678 2.104 0.213 1.386 3.194 3.492 0.000479 0.6166 0.08481 0.11371 0.062 rs9454967 Imputed G DOM 678 2.304 0.2264 1.478 3.592 3.687 0.000227 0.6166 0.08481 0.11371 0.062 rs9471295 Imputed T DOM 682 1.569 0.1754 1.112 2.213 2.567 0.01026 0.1579 0.14223 0.16667 0.123 rs9477007 Imputed A ADD 651 1.476 0.1133 1.182 1.842 3.433 0.000596 0.225 0.41014 0.46503 0.3671 rs9477007 Imputed A GEN 651 11.79 0.002754 0.225 0.41014 0.46503 0.3671 rs9487279 Imputed T DOM 653 0.61 0.165 0.4417 0.8435 −2.991 0.002778 0.5145 0.3974 0.35986 0.4272 rs949016 Imputed C ADD 682 1.55 0.1262 1.21 1.985 3.473 0.000515 0.7642 0.25806 0.305 0.2212 rs9555973 Imputed G ADD 681 0.538 0.1869 0.3726 0.7754 −3.321 0.000898 0.3277 0.11087 0.07833 0.1365 rs9555973 Imputed G DOM 681 0.501 0.2048 0.3354 0.7487 −3.373 0.000743 0.3277 0.11087 0.07833 0.1365 rs9557510 Imputed G ADD 680 1.629 0.1608 1.188 2.232 3.033 0.002418 0.7519 0.14044 0.17224 0.1155 rs9557510 Imputed G DOM 680 1.768 0.1765 1.251 2.498 3.227 0.001253 0.7519 0.14044 0.17224 0.1155 rs9560584 Imputed T DOM 660 0.489 0.211 0.3233 0.7393 −3.392 0.000695 0.3013 0.10606 0.07388 0.1314 rs9588770 Imputed T DOM 680 0.529 0.2039 0.3549 0.7895 −3.119 0.001815 0.3247 0.11029 0.08 0.1342 rs9588848 Imputed C ADD 682 0.518 0.1922 0.3551 0.7544 −3.426 0.000612 0.3055 0.10484 0.07167 0.1309 rs9588848 Imputed C DOM 682 0.474 0.2097 0.3145 0.7155 −3.556 0.000376 0.3055 0.10484 0.07167 0.1309 rs966583 Imputed A ADD 679 0.729 0.1149 0.5819 0.913 −2.752 0.005926 0.9364 0.40133 0.36409 0.4304 rs966583 Imputed A DOM 679 0.578 0.1648 0.4182 0.7977 −3.332 0.000863 0.9364 0.40133 0.36409 0.4304 rs974130 Genotyped A REC 682 1.891 0.2296 1.206 2.965 2.775 0.005522 0.4535 0.3563 0.36833 0.3469 rs977160 Imputed T ADD 681 1.657 0.1289 1.287 2.133 3.916 8.99E−05 0.919 0.25037 0.30333 0.2087 rs9812206 Imputed G ADD 682 0.481 0.2047 0.3217 0.7177 −3.581 0.000343 0.8253 0.09677 0.06333 0.123 rs9812206 Imputed G DOM 682 0.466 0.215 0.306 0.7107 −3.548 0.000388 0.8253 0.09677 0.06333 0.123 rs9813552 Imputed G ADD 673 0.487 0.2063 0.325 0.7298 −3.487 0.000489 1 0.09658 0.06376 0.1227 rs9813552 Imputed G DOM 673 0.472 0.2155 0.3093 0.7198 −3.486 0.000491 1 0.09658 0.06376 0.1227 rs9815037 Imputed T ADD 682 0.482 0.206 0.3221 0.7224 −3.539 0.000402 1 0.09604 0.06333 0.1217 rs9815037 Imputed T DOM 682 0.467 0.215 0.3063 0.7115 −3.543 0.000395 1 0.09604 0.06333 0.1217 rs9825349 Imputed A ADD 682 0.482 0.206 0.3221 0.7224 −3.539 0.000402 1 0.09604 0.06333 0.1217 rs9825349 Imputed A DOM 682 0.467 0.215 0.3063 0.7115 −3.543 0.000395 1 0.09604 0.06333 0.1217 rs9834217 Imputed T ADD 681 0.483 0.206 0.3226 0.7234 −3.532 0.000413 1 0.09618 0.06355 0.1217 rs9834217 Imputed T DOM 681 0.468 0.215 0.3069 0.7127 −3.535 0.000407 1 0.09618 0.06355 0.1217 rs9840460 Imputed T ADD 682 0.482 0.206 0.3221 0.7224 −3.539 0.000402 1 0.09604 0.06333 0.1217 rs9840460 Imputed T DOM 682 0.467 0.215 0.3063 0.7115 −3.543 0.000395 1 0.09604 0.06333 0.1217 rs9840756 Imputed A ADD 682 0.482 0.206 0.3221 0.7224 −3.539 0.000402 1 0.09604 0.06333 0.1217 rs9840756 Imputed A DOM 682 0.467 0.215 0.3063 0.7115 −3.543 0.000395 1 0.09604 0.06333 0.1217 rs9844801 Imputed C DOM 682 1.705 0.2034 1.144 2.541 2.623 0.008711 0.3705 0.09457 0.11333 0.0798 rs985375 Imputed A GEN 655 11.2 0.003703 0.4705 0.2542 0.2972 0.2209 rs9869187 Imputed C ADD 681 0.488 0.2129 0.3218 0.7413 −3.366 0.000764 0.8111 0.08884 0.05853 0.1126 rs9869187 Imputed C DOM 681 0.497 0.2215 0.3219 0.7671 −3.157 0.001595 0.8111 0.08884 0.05853 0.1126 rs9872327 Imputed T DOM 682 1.705 0.2034 1.144 2.541 2.623 0.008711 0.3705 0.09457 0.11333 0.0798 rs9881685 Imputed A ADD 682 0.481 0.2047 0.3217 0.7177 −3.581 0.000343 0.8253 0.09677 0.06333 0.123 rs9881685 Imputed A DOM 682 0.466 0.215 0.306 0.7107 −3.548 0.000388 0.8253 0.09677 0.06333 0.123 rs9909499 Imputed C DOM 668 1.42 0.1577 1.042 1.934 2.223 0.02622 0.8536 0.2979 0.3266 0.2749 rs9911847 Imputed G DOM 680 0.668 0.1793 0.4702 0.9495 −2.249 0.02452 0.7545 0.14338 0.12667 0.1566 rs9946886 Imputed G REC 232 0.3 0.3567 0.1492 0.6039 −3.374 0.000742 0.08656 0.44828 0.39908 0.4919 rs9958823 Imputed A ADD 679 1.579 0.1261 1.233 2.022 3.624 0.00029 0.6914 0.26068 0.30936 0.2224 rs9965248 Imputed T ADD 671 1.556 0.127 1.213 1.996 3.481 0.0005 0.7646 0.2608 0.30847 0.2234 ALLELE PRAVA_A1_HZ_(—) PRAVA_HET_(—) PRAVA_A2_HZ_(—) PLACEBO_A1_HZ_(—) PLACEBO_HET_(—) PLACEBO_A2_HZ_(—) SNP rs # SOURCE (A1) MODEL NMISS COUNT COUNT COUNT COUNT COUNT COUNT rs198460 Genotyped G REC 682 73 155 72 66 215 101 rs603940 Genotyped G REC 682 38 157 105 72 175 135 rs10021016 Genotyped G GEN 682 29 120 151 17 148 217 rs1003148 Imputed C ADD 674 38 132 129 83 166 126 rs1003148 Imputed C GEN 674 38 132 129 83 166 126 rs1003148 Imputed C REC 674 38 132 129 83 166 126 rs10046799 Imputed C ADD 671 82 140 70 133 173 73 rs10046799 Imputed C GEN 671 82 140 70 133 173 73 rs10051148 Imputed C DOM 681 36 113 151 45 198 138 rs10054055 Imputed T DOM 681 36 113 151 45 198 138 rs10067895 Imputed A DOM 672 36 110 151 45 193 137 rs1008705 Imputed C DOM 505 21 98 99 20 111 156 rs10105871 Imputed C DOM 592 42 135 82 52 132 149 rs10116807 Imputed A GEN 652 23 98 166 10 129 226 rs10116807 Imputed A REC 652 23 98 166 10 129 226 rs10121941 Imputed C DOM 682 2 40 258 6 83 293 rs10128638 Genotyped G DOM 682 66 139 95 97 204 81 rs1012924 Imputed G ADD 682 3 37 260 7 86 289 rs1012924 Imputed G DOM 682 3 37 260 7 86 289 rs1016030 Genotyped G ADD 680 61 144 94 51 177 153 rs1016030 Genotyped G GEN 680 61 144 94 51 177 153 rs1017558 Imputed A REC 668 52 112 130 39 185 150 rs10183431 Imputed T DOM 677 14 135 147 17 133 231 rs10195401 Imputed C DOM 671 45 157 94 52 162 161 rs10239416 Imputed A DOM 658 34 124 136 53 185 126 rs1032188 Imputed G GEN 682 20 123 157 43 165 174 rs1032188 Imputed G REC 682 20 123 157 43 165 174 rs10468988 Imputed G ADD 679 30 125 144 18 133 229 rs10478919 Imputed G DOM 681 36 112 152 46 198 137 rs10506623 Imputed C DOM 682 46 128 126 65 198 119 rs10506626 Imputed A DOM 682 49 122 129 61 204 117 rs10509477 Imputed T DOM 682 26 149 125 34 136 212 rs10511071 Imputed C DOM 682 2 64 234 6 49 327 rs10511072 Imputed G DOM 682 2 64 234 6 49 327 rs10511199 Imputed C ADD 679 21 111 166 11 123 247 rs10513283 Imputed G GEN 680 26 92 181 8 108 265 rs10520072 Imputed T DOM 681 36 113 151 45 198 138 rs1065639 Imputed C DOM 645 35 156 91 48 157 158 rs10733846 Imputed G ADD 676 5 73 221 29 116 232 rs10733846 Imputed G DOM 676 5 73 221 29 116 232 rs10737390 Imputed T DOM 678 42 119 139 62 192 124 rs10749293 Imputed G DOM 682 25 149 126 33 134 215 rs10752159 Imputed G DOM 676 16 113 169 15 117 246 rs10753760 Imputed T ADD 650 61 141 81 49 181 137 rs10753760 Imputed T GEN 650 61 141 81 49 181 137 rs10757887 Imputed C DOM 677 18 92 188 21 161 197 rs10758326 Imputed A ADD 679 32 138 128 68 177 136 rs10758326 Imputed A GEN 679 32 138 128 68 177 136 rs10758326 Imputed A REC 679 32 138 128 68 177 136 rs10762236 Genotyped G ADD 682 7 76 217 30 122 230 rs10765769 Imputed C ADD 676 66 150 81 59 174 146 rs10765769 Imputed C GEN 676 66 150 81 59 174 146 rs10784891 Imputed C ADD 656 49 138 101 83 195 90 rs10784891 Imputed C DOM 656 49 138 101 83 195 90 rs10787923 Imputed G DOM 672 25 149 123 33 131 211 rs10787949 Imputed A DOM 682 27 150 123 35 137 210 rs10787951 Imputed G DOM 682 27 150 123 35 137 210 rs10787983 Imputed C DOM 682 26 149 125 33 136 213 rs10788380 Imputed C ADD 675 78 162 56 78 192 109 rs10788380 Imputed C DOM 675 78 162 56 78 192 109 rs10788380 Imputed C GEN 675 78 162 56 78 192 109 rs10814418 Imputed G DOM 680 2 40 256 6 83 293 rs10831417 Imputed A ADD 674 61 143 94 47 176 153 rs10831417 Imputed A GEN 674 61 143 94 47 176 153 rs10831422 Imputed C ADD 676 61 144 93 48 178 152 rs10831422 Imputed C GEN 676 61 144 93 48 178 152 rs10862931 Imputed C GEN 676 21 129 146 60 159 161 rs10865197 Imputed C DOM 679 14 136 147 17 134 231 rs10871302 Imputed A DOM 677 8 82 207 7 77 296 rs10877463 Imputed C DOM 681 45 115 139 50 182 150 rs10877468 Imputed C DOM 681 45 116 138 49 183 150 rs10879240 Imputed C ADD 561 6 143 104 21 191 96 rs10879242 Imputed A DOM 600 52 113 99 70 184 82 rs10879245 Imputed G DOM 600 52 113 99 70 184 82 rs10879249 Imputed T DOM 676 46 127 125 65 197 116 rs10886452 Imputed A DOM 682 27 150 123 35 137 210 rs10886463 Imputed C DOM 682 27 150 123 35 137 210 rs10886465 Imputed A DOM 682 27 150 123 36 137 209 rs10886526 Imputed C DOM 681 25 149 125 34 136 212 rs10902437 Imputed G ADD 658 61 135 97 51 151 163 rs10941126 Imputed G ADD 682 0 9 291 3 36 343 rs10941126 Imputed G DOM 682 0 9 291 3 36 343 rs10947871 Imputed A DOM 682 5 90 205 4 86 292 rs10972978 Imputed G DOM 658 2 38 248 6 81 283 rs10973012 Imputed A DOM 682 2 40 258 6 83 293 rs10974028 Genotyped G ADD 682 9 57 234 13 122 247 rs10974028 Genotyped G DOM 682 9 57 234 13 122 247 rs11021302 Imputed A ADD 681 61 144 95 48 180 153 rs11021302 Imputed A GEN 681 61 144 95 48 180 153 rs11099644 Imputed G REC 668 52 112 130 39 185 150 rs11138315 Imputed G ADD 646 3 46 236 8 75 278 rs11149802 Imputed T DOM 677 8 82 207 7 77 296 rs1116596 Imputed T DOM 681 36 112 152 46 198 137 rs11178531 Imputed A ADD 678 60 140 98 92 204 84 rs11178531 Imputed A DOM 678 60 140 98 92 204 84 rs11178575 Imputed C GEN 679 44 121 133 28 168 185 rs11178575 Imputed C REC 679 44 121 133 28 168 185 rs11178577 Imputed T GEN 680 44 121 133 28 169 185 rs11178577 Imputed T REC 680 44 121 133 28 169 185 rs11178583 Imputed A DOM 665 46 124 121 65 197 112 rs11178589 Imputed T DOM 678 48 131 120 69 199 111 rs11178594 Imputed C DOM 680 46 127 125 65 199 118 rs11178602 Imputed T DOM 680 46 126 126 65 199 118 rs11178648 Imputed T DOM 680 49 121 129 62 202 117 rs11198877 Imputed T DOM 682 27 150 123 35 137 210 rs11198942 Imputed T DOM 680 26 149 124 34 135 212 rs11221075 Imputed A ADD 674 1 57 238 12 88 278 rs11242020 Imputed T DOM 682 36 112 152 46 199 137 rs11242021 Imputed T DOM 682 36 113 151 46 198 138 rs11242022 Imputed T DOM 682 36 113 151 46 198 138 rs11242023 Imputed T DOM 682 36 112 152 45 197 140 rs1149350 Imputed A DOM 680 11 121 167 12 119 250 rs1150143 Imputed G DOM 658 23 157 107 40 149 182 rs11576627 Imputed T ADD 682 3 89 208 2 71 309 rs11576627 Imputed T DOM 682 3 89 208 2 71 309 rs11602189 Imputed A DOM 677 29 112 156 48 180 152 rs11605163 Imputed A DOM 679 2 53 244 2 36 342 rs11615214 Imputed G ADD 660 31 122 139 76 161 131 rs11615214 Imputed G GEN 660 31 122 139 76 161 131 rs11642394 Imputed C DOM 677 8 82 207 7 77 296 rs11644943 Imputed A ADD 655 21 103 168 9 128 226 rs11656608 Imputed T DOM 681 8 58 233 6 109 267 rs11661309 Imputed A ADD 676 7 76 214 20 130 229 rs11661309 Imputed A DOM 676 7 76 214 20 130 229 rs11666131 Imputed A ADD 675 20 114 161 10 129 241 rs11743355 Imputed C ADD 650 0 8 279 3 34 326 rs11743355 Imputed C DOM 650 0 8 279 3 34 326 rs11746806 Imputed T ADD 682 0 10 290 3 36 343 rs11746806 Imputed T DOM 682 0 10 290 3 36 343 rs11746959 Imputed T ADD 682 0 9 291 3 36 343 rs11746959 Imputed T DOM 682 0 9 291 3 36 343 rs11749272 Imputed T DOM 679 36 111 151 46 198 137 rs11901899 Imputed A DOM 668 22 129 145 24 132 216 rs11926319 Imputed G ADD 675 1 36 260 6 82 290 rs11926319 Imputed G DOM 675 1 36 260 6 82 290 rs11956952 Imputed C DOM 671 21 104 171 35 166 174 rs12025826 Imputed G DOM 664 61 139 88 59 156 161 rs1204522 Imputed C GEN 676 27 143 128 68 178 132 rs1204524 Imputed A GEN 678 27 143 128 68 180 132 rs12153185 Imputed T DOM 672 36 110 151 45 193 137 rs12182651 Imputed T ADD 678 3 62 234 3 41 335 rs12182651 Imputed T DOM 678 3 62 234 3 41 335 rs12193568 Imputed G DOM 565 8 89 156 6 84 222 rs12264914 Imputed C DOM 361 17 59 84 33 89 79 rs12307767 Imputed C DOM 661 44 114 134 49 178 142 rs1232298 Imputed G REC 658 33 119 136 27 180 163 rs12407412 Imputed C ADD 682 3 89 208 2 71 309 rs12407412 Imputed C DOM 682 3 89 208 2 71 309 rs12420184 Imputed G DOM 681 9 57 234 10 118 253 rs12422750 Imputed A DOM 679 45 116 137 51 180 150 rs12446951 Imputed A ADD 520 1 41 187 0 29 262 rs12446951 Imputed A DOM 520 1 41 187 0 29 262 rs12457400 Imputed G DOM 680 4 42 253 5 88 288 rs1247340 Imputed C DOM 680 11 121 167 12 119 250 rs1247341 Imputed C DOM 680 11 121 167 12 119 250 rs12521291 Imputed G ADD 673 28 123 147 56 172 147 rs12526849 Imputed T ADD 656 63 137 87 52 164 153 rs12526849 Imputed T GEN 656 63 137 87 52 164 153 rs12543110 Imputed G DOM 681 17 119 163 27 108 247 rs12678600 Imputed A DOM 675 27 118 153 44 184 149 rs12719415 Imputed T DOM 673 31 111 151 43 199 138 rs12831292 Imputed G DOM 678 46 126 125 65 199 117 rs12923993 Imputed C DOM 677 8 82 207 7 77 296 rs12936964 Imputed T DOM 673 45 149 102 45 155 177 rs12960663 Imputed G ADD 672 7 76 213 20 127 229 rs13038146 Imputed C ADD 681 54 130 116 40 170 171 rs13038146 Imputed C GEN 681 54 130 116 40 170 171 rs13134222 Imputed A GEN 597 10 105 152 32 132 166 rs13172910 Imputed A DOM 675 22 105 171 35 168 174 rs13194907 Imputed A ADD 682 3 49 248 2 31 349 rs13194907 Imputed A DOM 682 3 49 248 2 31 349 rs13195745 Imputed A ADD 682 3 49 248 2 31 349 rs13195745 Imputed A DOM 682 3 49 248 2 31 349 rs1321432 Imputed A REC 681 60 145 94 39 186 157 rs1321457 Imputed G REC 665 59 140 93 39 181 153 rs13265054 Imputed T DOM 671 27 116 153 42 182 151 rs13282131 Imputed C GEN 675 72 142 80 65 190 126 rs13353526 Imputed C DOM 674 2 64 230 6 48 324 rs1336382 Imputed T DOM 682 26 149 125 34 136 212 rs1336383 Imputed T DOM 682 26 149 125 34 136 212 rs1336407 Imputed T DOM 682 26 149 125 34 136 212 rs1336409 Imputed T DOM 682 26 149 125 34 136 212 rs1336596 Imputed A DOM 682 37 114 149 46 194 142 rs1343560 Imputed T ADD 678 3 37 257 7 86 288 rs1343560 Imputed T DOM 678 3 37 257 7 86 288 rs1361987 Imputed T GEN 682 28 145 127 72 180 130 rs1386153 Imputed T ADD 677 27 115 157 47 180 151 rs1386153 Imputed T DOM 677 27 115 157 47 180 151 rs1394015 Imputed C DOM 669 35 160 97 49 160 168 rs1407038 Imputed A REC 678 59 141 96 39 184 159 rs1407039 Imputed A REC 680 61 144 93 42 186 154 rs1412802 Imputed T GEN 681 17 128 155 43 163 175 rs1414865 Imputed T DOM 682 27 150 123 35 137 210 rs1414873 Imputed A DOM 682 26 149 125 33 136 213 rs1414876 Imputed C DOM 682 26 149 125 33 136 213 rs1418671 Imputed C REC 655 57 125 106 36 165 166 rs1419490 Genotyped T GEN 682 28 144 128 72 180 130 rs1434507 Imputed A ADD 681 28 126 146 18 132 231 rs1434508 Imputed T ADD 681 28 126 146 18 133 230 rs1435205 Imputed A ADD 679 21 111 166 11 123 247 rs1443928 Imputed C REC 672 66 165 65 123 177 76 rs1452235 Imputed G GEN 682 21 130 149 60 159 163 rs1452236 Imputed G GEN 681 21 130 149 60 159 162 rs1452237 Imputed G GEN 682 21 130 149 60 159 163 rs1452243 Genotyped T GEN 682 21 130 149 60 159 163 rs1463768 Genotyped G REC 682 63 135 102 57 184 141 rs1463769 Imputed G REC 682 63 135 102 56 184 142 rs1472435 Imputed A ADD 675 0 31 267 5 55 317 rs1472435 Imputed A DOM 675 0 31 267 5 55 317 rs1476714 Imputed A DOM 681 36 112 151 46 198 138 rs1495159 Imputed G ADD 671 19 125 150 48 170 159 rs1495159 Imputed G GEN 671 19 125 150 48 170 159 rs1495375 Imputed A DOM 674 52 127 117 70 202 106 rs1495376 Imputed T DOM 649 70 125 87 86 202 79 rs1495377 Imputed G DOM 652 71 126 87 86 202 80 rs1495381 Imputed T GEN 682 59 140 101 41 198 143 rs1495381 Imputed T REC 682 59 140 101 41 198 143 rs1498992 Imputed G DOM 681 28 109 162 47 179 156 rs1499001 Imputed T DOM 661 16 100 173 38 159 175 rs1512988 Imputed A DOM 681 45 128 126 65 198 119 rs1512989 Imputed T DOM 681 45 128 126 65 198 119 rs1512991 Imputed T ADD 677 57 141 99 88 203 89 rs1512991 Imputed T DOM 677 57 141 99 88 203 89 rs1516855 Imputed G REC 657 49 140 100 37 188 143 rs1527450 Imputed T ADD 670 61 143 94 47 174 151 rs1527450 Imputed T GEN 670 61 143 94 47 174 151 rs1567740 Imputed T DOM 679 46 126 125 65 198 119 rs1572573 Imputed A ADD 657 16 104 167 13 85 272 rs1572573 Imputed A DOM 657 16 104 167 13 85 272 rs1584003 Imputed C DOM 673 70 161 63 86 160 133 rs1584005 Imputed C DOM 665 67 159 63 86 158 132 rs1585771 Imputed G ADD 674 31 119 145 20 133 226 rs1592015 Imputed G DOM 681 10 62 227 14 130 238 rs1594885 Imputed A ADD 681 30 126 144 19 133 229 rs1603232 Imputed A DOM 655 72 126 89 84 201 83 rs1614565 Imputed C DOM 671 75 127 93 85 210 81 rs1648200 Imputed G ADD 623 19 120 129 20 120 215 rs16877387 Imputed C GEN 677 51 124 122 32 166 182 rs16877387 Imputed C REC 677 51 124 122 32 166 182 rs16938626 Imputed G DOM 663 23 106 167 33 170 164 rs1694334 Imputed G ADD 599 10 82 169 36 116 186 rs16998821 Imputed C DOM 681 10 62 227 14 130 238 rs1700400 Imputed T ADD 672 11 110 175 31 155 190 rs17007620 Imputed G ADD 599 16 110 134 15 108 216 rs17007620 Imputed G DOM 599 16 110 134 15 108 216 rs17023290 Imputed C DOM 682 2 64 234 6 49 327 rs17047957 Imputed C DOM 681 7 101 191 16 87 279 rs1705237 Imputed A DOM 666 71 127 93 85 209 81 rs1705261 Imputed A GEN 682 59 140 101 41 196 145 rs1705261 Imputed A REC 682 59 140 101 41 196 145 rs17076972 Imputed C ADD 682 86 144 70 68 196 118 rs17076972 Imputed C GEN 682 86 144 70 68 196 118 rs17076972 Imputed C REC 682 86 144 70 68 196 118 rs17189710 Imputed T ADD 681 54 130 116 40 170 171 rs17189710 Imputed T GEN 681 54 130 116 40 170 171 rs17196143 Imputed A ADD 682 12 118 170 12 103 267 rs17353809 Imputed G ADD 674 22 106 167 10 121 248 rs17368986 Imputed A GEN 682 26 93 181 8 108 266 rs17369097 Imputed A GEN 681 24 95 181 8 106 267 rs17434511 Imputed C GEN 679 26 92 180 8 108 265 rs17434589 Imputed C GEN 673 26 92 177 8 107 263 rs17434603 Imputed G GEN 680 26 92 181 8 108 265 rs17434840 Imputed C GEN 681 24 95 181 8 106 267 rs17446418 Imputed G DOM 678 35 119 144 59 193 128 rs17530747 Imputed T DOM 669 32 117 144 58 190 128 rs17604285 Imputed C ADD 681 2 37 261 7 80 294 rs17604285 Imputed C DOM 681 2 37 261 7 80 294 rs17662322 Imputed T DOM 681 4 74 221 18 129 235 rs17769826 Imputed T ADD 677 22 106 169 10 121 249 rs17821641 Imputed T ADD 679 21 111 166 11 123 247 rs1782328 Imputed A ADD 647 6 74 203 26 117 221 rs1796337 Imputed T DOM 669 77 131 88 102 195 76 rs1798083 Imputed C DOM 674 74 130 92 85 210 83 rs1798085 Imputed T DOM 668 74 127 92 85 209 81 rs1798086 Imputed T DOM 668 73 125 95 85 209 81 rs1798089 Imputed C GEN 675 59 138 100 40 195 143 rs1798089 Imputed C REC 675 59 138 100 40 195 143 rs1798090 Imputed C GEN 674 59 139 98 41 195 142 rs1798090 Imputed C REC 674 59 139 98 41 195 142 rs1832222 Imputed G DOM 682 26 149 125 33 136 213 rs1838104 Imputed A ADD 668 71 157 64 128 187 61 rs1838104 Imputed A GEN 668 71 157 64 128 187 61 rs1868616 Imputed G ADD 671 4 78 213 18 133 225 rs1874313 Imputed A DOM 674 46 126 124 65 198 115 rs1884902 Imputed C REC 678 61 145 93 41 185 153 rs1913201 Imputed G ADD 650 45 139 101 79 194 92 rs1913201 Imputed G DOM 650 45 139 101 79 194 92 rs1913201 Imputed G GEN 650 45 139 101 79 194 92 rs1944279 Imputed A ADD 679 30 125 144 18 133 229 rs198461 Imputed C DOM 676 71 152 74 101 212 66 rs1987179 Imputed T DOM 680 10 91 198 11 149 221 rs1990023 Imputed T DOM 682 36 112 152 46 199 137 rs2016194 Imputed G DOM 682 36 113 151 46 198 138 rs2024789 Imputed C ADD 666 49 133 108 94 186 96 rs2024789 Imputed C GEN 666 49 133 108 94 186 96 rs2024902 Imputed A ADD 678 3 52 243 3 36 341 rs2024902 Imputed A DOM 678 3 52 243 3 36 341 rs2025107 Imputed A ADD 682 3 66 231 4 46 332 rs2025107 Imputed A DOM 682 3 66 231 4 46 332 rs2025108 Imputed T ADD 682 3 66 231 4 46 332 rs2025108 Imputed T DOM 682 3 66 231 4 46 332 rs2062448 Imputed T ADD 674 2 36 260 7 76 293 rs2062448 Imputed T DOM 674 2 36 260 7 76 293 rs2063591 Imputed C ADD 677 61 139 98 92 203 84 rs2063591 Imputed C DOM 677 61 139 98 92 203 84 rs2065604 Imputed C DOM 682 2 40 258 6 83 293 rs2066238 Imputed T DOM 682 10 62 228 14 130 238 rs2068051 Imputed G ADD 424 55 92 46 98 100 33 rs2068051 Imputed G GEN 424 55 92 46 98 100 33 rs2077702 Genotyped G GEN 682 44 122 134 28 168 186 rs208757 Imputed G ADD 652 9 102 177 8 92 264 rs208757 Imputed G DOM 652 9 102 177 8 92 264 rs2095586 Imputed A DOM 682 26 149 125 33 136 213 rs2108426 Imputed C DOM 682 36 113 151 46 198 138 rs2110664 Imputed A DOM 643 24 125 133 22 132 207 rs2132242 Imputed A DOM 680 48 130 120 69 201 112 rs2151644 Imputed T DOM 679 2 40 257 6 83 291 rs2157752 Genotyped A GEN 682 24 136 140 65 171 146 rs2158958 Imputed A DOM 682 36 113 151 46 198 138 rs2158961 Imputed G DOM 680 36 113 151 45 197 138 rs2164099 Imputed G ADD 681 30 126 144 19 133 229 rs2173254 Imputed G GEN 675 17 141 138 51 183 145 rs2173254 Imputed G REC 675 17 141 138 51 183 145 rs2188079 Imputed C ADD 682 71 148 81 53 190 139 rs2188079 Imputed C GEN 682 71 148 81 53 190 139 rs2190304 Imputed G REC 682 44 168 88 105 188 89 rs2190597 Imputed T DOM 681 63 133 104 86 208 87 rs2190598 Imputed T DOM 682 36 113 151 46 198 138 rs2190600 Imputed A DOM 672 36 110 151 45 193 137 rs2218084 Imputed T GEN 664 19 74 202 7 92 270 rs2218084 Imputed T REC 664 19 74 202 7 92 270 rs2236290 Genotyped C GEN 680 30 136 134 62 171 147 rs2243860 Imputed A GEN 548 50 117 74 33 164 110 rs2243860 Imputed A REC 548 50 117 74 33 164 110 rs2246564 Imputed T DOM 682 2 40 258 6 83 293 rs2248236 Imputed C DOM 681 10 93 197 11 149 221 rs2250340 Imputed T DOM 600 2 39 224 6 80 249 rs2257192 Imputed G DOM 682 2 40 258 6 83 293 rs2270584 Imputed A DOM 679 49 121 129 62 201 117 rs2270586 Imputed A DOM 680 49 121 129 61 203 117 rs2270589 Imputed A ADD 682 54 133 113 83 202 97 rs2270589 Imputed A DOM 682 54 133 113 83 202 97 rs2270589 Imputed A GEN 682 54 133 113 83 202 97 rs2296889 Imputed C DOM 672 3 98 196 11 79 285 rs2301346 Imputed C ADD 550 32 106 104 23 112 173 rs2301346 Imputed C DOM 550 32 106 104 23 112 173 rs2327929 Imputed G REC 682 77 130 93 55 181 146 rs2357486 Imputed C REC 673 48 129 121 25 175 175 rs2373793 Imputed G DOM 646 11 84 197 9 75 270 rs2377622 Imputed T GEN 552 18 109 105 49 140 131 rs2377622 Imputed T REC 552 18 109 105 49 140 131 rs2383903 Imputed G DOM 681 22 103 175 33 172 176 rs2389866 Imputed C DOM 681 10 91 199 11 149 221 rs2389869 Imputed C DOM 681 10 91 199 11 149 221 rs2418541 Imputed A DOM 681 36 112 152 46 198 137 rs2418542 Imputed A DOM 681 36 112 152 46 198 137 rs2418548 Imputed C DOM 630 33 102 150 35 174 136 rs2476976 Imputed C DOM 681 25 149 125 34 138 210 rs2483639 Imputed A DOM 682 2 40 258 6 83 293 rs2483640 Imputed A DOM 682 2 40 258 6 83 293 rs2544780 Imputed T REC 670 43 124 125 32 154 192 rs2586458 Imputed T DOM 322 3 21 105 5 55 133 rs2593272 Imputed G ADD 682 12 111 177 31 157 194 rs2593273 Imputed T ADD 678 10 111 177 29 157 194 rs2622499 Imputed G DOM 682 11 94 195 12 150 220 rs264126 Imputed C DOM 679 63 133 104 86 207 86 rs264129 Imputed T DOM 681 36 113 151 46 197 138 rs2656822 Imputed T ADD 682 12 111 177 31 157 194 rs2656823 Imputed G ADD 682 12 111 177 31 157 194 rs2656825 Imputed T ADD 665 9 109 174 29 151 193 rs2764766 Imputed C REC 678 44 128 125 34 156 191 rs2793101 Imputed T ADD 680 1 45 254 7 92 281 rs2793101 Imputed T DOM 680 1 45 254 7 92 281 rs2795871 Imputed A ADD 676 0 31 267 5 56 317 rs2795886 Imputed A ADD 681 0 19 281 4 40 337 rs2795886 Imputed A DOM 681 0 19 281 4 40 337 rs2859994 Imputed C GEN 645 49 143 95 34 181 143 rs2870464 Imputed G DOM 682 9 84 207 7 81 294 rs2875528 Imputed T DOM 682 2 64 234 6 49 327 rs2876227 Imputed C ADD 640 50 122 107 36 156 169 rs2876227 Imputed C GEN 640 50 122 107 36 156 169 rs2882097 Imputed A DOM 682 26 149 125 34 136 212 rs2921983 Imputed C ADD 640 9 96 176 25 143 191 rs2987537 Imputed C DOM 682 5 44 251 9 97 276 rs2996416 Imputed C ADD 682 3 37 260 7 86 289 rs2996416 Imputed C DOM 682 3 37 260 7 86 289 rs3015527 Imputed C ADD 677 3 37 259 7 85 286 rs3015527 Imputed C DOM 677 3 37 259 7 85 286 rs3015530 Imputed C ADD 682 3 37 260 7 86 289 rs3015530 Imputed C DOM 682 3 37 260 7 86 289 rs3015531 Imputed T ADD 682 3 37 260 7 86 289 rs3015531 Imputed T DOM 682 3 37 260 7 86 289 rs3015535 Imputed C ADD 682 3 37 260 7 86 289 rs3015535 Imputed C DOM 682 3 37 260 7 86 289 rs3019407 Imputed A GEN 675 17 141 138 51 183 145 rs3019407 Imputed A REC 675 17 141 138 51 183 145 rs36071725 Genotyped C GEN 682 49 132 119 25 180 177 rs373983 Imputed G DOM 661 55 151 86 52 155 162 rs3756154 Imputed C DOM 681 10 91 199 11 149 221 rs3793044 Imputed C ADD 682 3 49 248 2 31 349 rs3793044 Imputed C DOM 682 3 49 248 2 31 349 rs3793053 Imputed C ADD 672 3 62 233 3 43 328 rs3793053 Imputed C DOM 672 3 62 233 3 43 328 rs3796246 Imputed G ADD 682 1 37 262 5 81 296 rs3796246 Imputed G DOM 682 1 37 262 5 81 296 rs3805996 Imputed G ADD 662 3 51 238 3 33 334 rs3805996 Imputed G DOM 662 3 51 238 3 33 334 rs3806003 Imputed A ADD 682 3 49 248 2 31 349 rs3806003 Imputed A DOM 682 3 49 248 2 31 349 rs3806004 Imputed T ADD 682 3 66 231 4 46 332 rs3806004 Imputed T DOM 682 3 66 231 4 46 332 rs3806010 Imputed T ADD 682 3 66 231 4 46 332 rs3806010 Imputed T DOM 682 3 66 231 4 46 332 rs3806014 Imputed T ADD 682 3 66 231 4 46 332 rs3806014 Imputed T DOM 682 3 66 231 4 46 332 rs3806015 Imputed A ADD 682 3 66 231 4 46 332 rs3806015 Imputed A DOM 682 3 66 231 4 46 332 rs3806018 Imputed A ADD 682 3 66 231 4 46 332 rs3806018 Imputed A DOM 682 3 66 231 4 46 332 rs3806019 Imputed A ADD 678 3 63 233 3 41 335 rs3806019 Imputed A DOM 678 3 63 233 3 41 335 rs3806024 Imputed T ADD 672 3 62 233 3 43 328 rs3806024 Imputed T DOM 672 3 62 233 3 43 328 rs3847825 Imputed G ADD 680 33 126 140 75 166 140 rs3847825 Imputed G GEN 680 33 126 140 75 166 140 rs3852001 Genotyped C GEN 682 26 93 181 8 108 266 rs3852001 Genotyped C REC 682 26 93 181 8 108 266 rs3852002 Imputed G GEN 681 25 93 181 8 107 267 rs3852002 Imputed G REC 681 25 93 181 8 107 267 rs3852003 Imputed A GEN 681 25 93 181 8 107 267 rs3852003 Imputed A REC 681 25 93 181 8 107 267 rs3942254 Imputed T DOM 678 46 128 123 65 198 118 rs3945085 Imputed A DOM 682 25 149 126 33 134 215 rs399485 Imputed A DOM 678 27 129 142 24 134 222 rs4029119 Imputed G ADD 682 0 10 290 3 36 343 rs4029119 Imputed G DOM 682 0 10 290 3 36 343 rs412791 Imputed C GEN 675 27 143 128 69 178 130 rs4146972 Genotyped T DOM 682 8 103 189 16 95 271 rs4259369 Imputed C REC 679 50 142 107 89 159 132 rs4273613 Imputed T ADD 682 0 10 290 3 36 343 rs4273613 Imputed T DOM 682 0 10 290 3 36 343 rs4294022 Imputed C DOM 659 13 88 187 23 147 201 rs4310554 Genotyped C DOM 682 81 163 56 79 195 108 rs4315598 Imputed T ADD 682 54 130 116 40 170 172 rs4315598 Imputed T GEN 682 54 130 116 40 170 172 rs4370878 Imputed G DOM 682 25 149 126 33 136 213 rs4436200 Imputed C ADD 682 5 56 239 10 92 280 rs4444612 Imputed G ADD 682 54 130 116 40 170 172 rs4444612 Imputed G GEN 682 54 130 116 40 170 172 rs4450660 Imputed C DOM 675 15 135 147 16 131 231 rs4463950 Imputed C DOM 671 56 128 112 69 203 103 rs4509702 Imputed C DOM 682 25 149 126 33 136 213 rs4533379 Imputed G ADD 681 30 126 144 19 133 229 rs4569984 Imputed A DOM 671 13 90 192 24 146 206 rs4570530 Imputed C DOM 681 25 149 126 33 135 213 rs4571583 Imputed T DOM 666 13 89 189 23 147 205 rs4586678 Imputed A DOM 678 15 136 147 17 132 231 rs4615971 Imputed C DOM 676 26 148 122 33 136 211 rs4629229 Imputed G DOM 682 10 62 228 14 130 238 rs4632512 Imputed T GEN 681 24 95 181 8 106 267 rs4641552 Imputed A ADD 678 0 29 270 4 60 315 rs4682527 Imputed C DOM 656 39 157 91 49 163 157 rs4688632 Imputed G REC 675 50 168 77 105 182 93 rs4702720 Imputed A ADD 530 11 64 166 23 107 159 rs4702720 Imputed A DOM 530 11 64 166 23 107 159 rs4714484 Imputed A ADD 681 5 68 227 14 119 248 rs4714484 Imputed A DOM 681 5 68 227 14 119 248 rs4725142 Genotyped G REC 682 23 156 121 58 171 153 rs4725144 Imputed G REC 677 21 154 123 56 169 154 rs4760785 Imputed A ADD 657 49 139 101 82 194 92 rs4760785 Imputed A DOM 657 49 139 101 82 194 92 rs4760894 Imputed T ADD 657 49 139 101 82 194 92 rs4760894 Imputed T DOM 657 49 139 101 82 194 92 rs4760895 Imputed A ADD 657 49 139 101 82 194 92 rs4760895 Imputed A DOM 657 49 139 101 82 194 92 rs4767184 Imputed C ADD 678 37 124 138 75 169 135 rs4767184 Imputed C GEN 678 37 124 138 75 169 135 rs4773487 Imputed T ADD 682 3 43 254 9 88 285 rs4780547 Imputed G GEN 682 9 97 194 31 125 226 rs4780547 Imputed G REC 682 9 97 194 31 125 226 rs483159 Imputed T DOM 611 11 105 155 12 90 238 rs4836502 Imputed T DOM 682 36 113 151 46 198 138 rs4836507 Imputed C DOM 672 36 110 151 45 193 137 rs4851531 Imputed T DOM 677 44 136 118 68 190 121 rs4879931 Imputed G ADD 678 22 109 166 48 164 169 rs489441 Imputed G ADD 631 20 128 127 19 123 214 rs489441 Imputed G DOM 631 20 128 127 19 123 214 rs4976276 Imputed T ADD 681 32 143 125 21 166 194 rs4977681 Imputed C REC 682 41 116 143 22 166 194 rs4986197 Imputed G ADD 679 30 125 143 19 133 229 rs4986220 Imputed T ADD 681 28 125 146 18 133 231 rs525462 Imputed A GEN 682 88 142 70 136 174 72 rs552006 Imputed G GEN 678 44 108 146 28 143 209 rs5756669 Imputed C DOM 679 66 164 68 75 173 133 rs581905 Imputed T DOM 681 3 55 242 1 46 334 rs6033138 Imputed C ADD 682 54 130 116 40 170 172 rs6033138 Imputed C GEN 682 54 130 116 40 170 172 rs6040619 Imputed C ADD 677 55 129 114 41 168 170 rs6040619 Imputed C GEN 677 55 129 114 41 168 170 rs6040625 Imputed T ADD 680 55 131 114 41 168 171 rs6040625 Imputed T GEN 680 55 131 114 41 168 171 rs6040630 Imputed A ADD 679 54 132 114 40 168 171 rs6040630 Imputed A GEN 679 54 132 114 40 168 171 rs6040633 Imputed A ADD 679 54 132 114 40 168 171 rs6040633 Imputed A GEN 679 54 132 114 40 168 171 rs6040634 Imputed T ADD 682 54 132 114 43 169 170 rs6040634 Imputed T GEN 682 54 132 114 43 169 170 rs6040636 Imputed T ADD 681 54 132 114 43 168 170 rs6040636 Imputed T GEN 681 54 132 114 43 168 170 rs6040638 Imputed C ADD 682 54 130 116 40 170 172 rs6040638 Imputed C GEN 682 54 130 116 40 170 172 rs6040644 Imputed A ADD 680 54 130 115 40 170 171 rs6040644 Imputed A GEN 680 54 130 115 40 170 171 rs6040667 Imputed T ADD 669 50 128 115 36 162 178 rs6040667 Imputed T GEN 669 50 128 115 36 162 178 rs6040668 Imputed C ADD 669 50 128 115 36 162 178 rs6040668 Imputed C GEN 669 50 128 115 36 162 178 rs6053005 Imputed C DOM 479 78 90 38 94 144 35 rs6054405 Imputed A REC 679 61 144 93 41 186 154 rs6054427 Genotyped G GEN 682 59 150 91 44 186 152 rs6075186 Imputed G DOM 682 10 62 228 14 130 238 rs608278 Imputed A ADD 594 39 114 104 66 173 98 rs6111540 Imputed A ADD 630 45 138 92 99 174 82 rs6131206 Imputed C ADD 668 36 120 135 29 149 199 rs6131208 Imputed T ADD 669 50 128 115 36 162 178 rs6131208 Imputed T GEN 669 50 128 115 36 162 178 rs6131919 Imputed G DOM 682 10 62 228 14 130 238 rs6134243 Imputed C ADD 682 54 130 116 40 170 172 rs6134243 Imputed C GEN 682 54 130 116 40 170 172 rs6136020 Imputed A DOM 681 10 61 228 14 130 238 rs613799 Imputed C DOM 582 20 125 107 28 115 187 rs644041 Imputed G ADD 621 21 126 125 18 123 208 rs644041 Imputed G DOM 621 21 126 125 18 123 208 rs6464377 Imputed C DOM 681 0 59 241 2 36 343 rs6474230 Imputed T DOM 681 17 119 163 27 108 247 rs6476565 Imputed A DOM 677 2 39 256 6 82 292 rs6511286 Imputed T ADD 675 37 138 123 35 148 194 rs6541829 Genotyped C REC 682 28 117 155 20 146 216 rs6544721 Imputed G DOM 675 14 134 147 16 132 232 rs6544728 Imputed T DOM 680 15 135 149 14 133 234 rs6565910 Imputed G DOM 675 19 87 191 30 152 196 rs6581985 Imputed G GEN 661 35 120 136 21 161 188 rs6581985 Imputed G REC 661 35 120 136 21 161 188 rs6685186 Imputed T ADD 680 63 146 90 46 179 156 rs6685186 Imputed T GEN 680 63 146 90 46 179 156 rs670593 Imputed A REC 678 37 157 105 71 172 136 rs6722640 Imputed T DOM 682 47 133 120 69 193 120 rs6746170 Imputed A DOM 679 15 135 148 14 133 234 rs6757316 Imputed A GEN 675 73 131 93 52 189 137 rs6805139 Imputed G DOM 681 78 170 52 95 180 106 rs6808571 Imputed G ADD 675 13 89 197 4 78 294 rs6816479 Imputed A REC 681 52 116 131 39 187 156 rs6865976 Imputed C DOM 636 53 129 95 88 197 74 rs687047 Imputed C ADD 682 1 57 242 12 89 281 rs6871041 Imputed G DOM 625 28 100 151 33 175 138 rs688358 Imputed A ADD 672 1 57 238 12 88 276 rs6908481 Imputed C REC 664 66 124 100 47 178 149 rs6917224 Imputed A ADD 682 64 143 93 51 173 158 rs6917224 Imputed A GEN 682 64 143 93 51 173 158 rs6920677 Imputed G DOM 669 41 124 132 61 184 127 rs6994498 Imputed G DOM 679 16 119 163 27 107 247 rs6998772 Imputed T DOM 682 2 43 255 2 25 355 rs7022281 Imputed C ADD 678 33 142 124 69 177 133 rs7022281 Imputed C GEN 678 33 142 124 69 177 133 rs7022281 Imputed C REC 678 33 142 124 69 177 133 rs7043983 Imputed T DOM 678 2 39 256 6 82 293 rs7077799 Imputed A DOM 682 26 149 125 34 136 212 rs7088947 Imputed A ADD 681 0 31 269 5 56 320 rs7089661 Imputed C DOM 682 26 149 125 33 136 213 rs7102072 Imputed A DOM 681 24 97 179 36 171 174 rs710832 Genotyped A REC 682 12 120 168 37 127 218 rs712531 Imputed A DOM 671 35 161 95 48 164 168 rs7129817 Imputed T ADD 674 30 120 148 56 178 142 rs7134262 Imputed T GEN 678 55 117 127 30 196 153 rs7134262 Imputed T REC 678 55 117 127 30 196 153 rs7138300 Imputed C ADD 657 49 139 101 82 194 92 rs7138300 Imputed C DOM 657 49 139 101 82 194 92 rs722927 Imputed G ADD 660 1 27 267 5 62 298 rs722927 Imputed G DOM 660 1 27 267 5 62 298 rs726424 Genotyped G ADD 682 35 127 138 76 166 140 rs726424 Genotyped G GEN 682 35 127 138 76 166 140 rs7295817 Imputed C ADD 677 36 132 129 85 170 125 rs7295817 Imputed C GEN 677 36 132 129 85 170 125 rs7295817 Imputed C REC 677 36 132 129 85 170 125 rs7297372 Imputed A ADD 682 80 152 68 139 186 57 rs7297372 Imputed A GEN 682 80 152 68 139 186 57 rs7298255 Imputed A ADD 682 57 142 101 89 203 90 rs7298255 Imputed A DOM 682 57 142 101 89 203 90 rs7305832 Imputed C GEN 678 55 117 127 30 196 153 rs7305832 Imputed C REC 678 55 117 127 30 196 153 rs737542 Imputed A REC 678 28 116 154 20 145 215 rs742827 Imputed A ADD 637 50 123 105 37 155 167 rs742827 Imputed A GEN 637 50 123 105 37 155 167 rs7446891 Imputed G DOM 681 36 113 151 45 198 138 rs7448641 Imputed C ADD 682 0 9 291 3 36 343 rs7448641 Imputed C DOM 682 0 9 291 3 36 343 rs7460605 Imputed G DOM 638 52 144 87 60 146 149 rs7468898 Imputed T ADD 674 74 153 72 61 195 119 rs7468898 Imputed T GEN 674 74 153 72 61 195 119 rs7501186 Imputed A DOM 677 8 82 207 7 77 296 rs755117 Imputed A DOM 651 13 105 171 16 93 253 rs7557560 Imputed T GEN 679 18 95 186 7 120 253 rs7557560 Imputed T REC 679 18 95 186 7 120 253 rs7562462 Imputed T DOM 673 65 153 75 70 161 149 rs757173 Genotyped G DOM 682 32 122 146 57 194 131 rs7607447 Imputed T REC 676 33 111 153 24 162 193 rs7639053 Imputed A ADD 682 22 107 171 10 121 251 rs7648163 Imputed C REC 654 45 111 132 31 167 168 rs7651273 Imputed A GEN 680 26 93 180 8 108 265 rs7653190 Imputed C ADD 677 22 106 169 10 121 249 rs7653685 Genotyped C DOM 682 2 64 234 6 49 327 rs7684899 Imputed C DOM 682 10 93 197 11 150 221 rs7701604 Imputed G ADD 682 0 9 291 3 36 343 rs7701604 Imputed G DOM 682 0 9 291 3 36 343 rs7703676 Imputed C ADD 682 0 9 291 3 36 343 rs7703676 Imputed C DOM 682 0 9 291 3 36 343 rs7711358 Imputed A DOM 677 36 112 149 46 197 137 rs7713251 Imputed C REC 661 44 130 120 28 171 168 rs7737608 Imputed G DOM 676 44 155 96 48 150 183 rs7755903 Imputed A GEN 681 44 145 111 80 190 111 rs7762993 Imputed A ADD 677 16 111 170 14 90 276 rs7762993 Imputed A DOM 677 16 111 170 14 90 276 rs7767265 Imputed G DOM 663 22 116 149 19 98 259 rs7769415 Imputed C GEN 670 39 126 129 31 166 179 rs7771264 Imputed T DOM 654 13 88 184 23 147 199 rs7795792 Imputed T REC 679 50 142 107 89 159 132 rs7806481 Imputed G REC 682 44 168 88 105 188 89 rs7808536 Imputed G DOM 678 11 115 173 16 111 252 rs7814819 Imputed G ADD 395 2 41 138 1 22 191 rs7814819 Imputed G DOM 395 2 41 138 1 22 191 rs7815952 Imputed T DOM 682 2 43 255 2 25 355 rs7834090 Imputed T DOM 682 2 43 255 2 25 355 rs7859250 Imputed C DOM 679 2 39 256 6 83 293 rs7863577 Genotyped A ADD 682 1 40 259 7 85 290 rs7863577 Genotyped A DOM 682 1 40 259 7 85 290 rs7902140 Imputed C ADD 673 6 79 212 26 120 230 rs7921834 Imputed C DOM 682 26 149 125 33 136 213 rs7939893 Imputed C ADD 682 33 113 154 64 161 157 rs7939893 Imputed C DOM 682 33 113 154 64 161 157 rs7955901 Imputed C ADD 675 57 140 101 89 199 89 rs7955901 Imputed C DOM 675 57 140 101 89 199 89 rs7956274 Imputed T ADD 677 57 141 99 88 202 90 rs7956274 Imputed T DOM 677 57 141 99 88 202 90 rs7957932 Imputed G ADD 671 60 139 97 89 202 84 rs7957932 Imputed G DOM 671 60 139 97 89 202 84 rs7984294 Imputed A DOM 678 5 69 224 4 66 310 rs7994286 Imputed A ADD 674 3 39 252 8 87 285 rs7994286 Imputed A DOM 674 3 39 252 8 87 285 rs8038229 Genotyped A ADD 682 26 109 165 40 162 180 rs8038229 Genotyped A DOM 682 26 109 165 40 162 180 rs8043336 Imputed C GEN 647 21 132 129 56 158 151 rs8043336 Imputed C REC 647 21 132 129 56 158 151 rs8054431 Imputed T DOM 652 41 155 90 49 161 156 rs8066502 Imputed T DOM 681 8 60 232 6 107 268 rs8068714 Imputed T DOM 682 8 59 233 6 107 269 rs892575 Imputed T ADD 681 28 127 145 19 131 231 rs892583 Imputed G ADD 679 28 126 145 18 133 229 rs915494 Imputed A ADD 647 23 140 123 25 126 210 rs915494 Imputed A DOM 647 23 140 123 25 126 210 rs917295 Imputed G DOM 681 36 113 151 45 198 138 rs922594 Imputed T DOM 681 45 115 139 50 182 150 rs9301653 Imputed T ADD 682 3 37 260 7 86 289 rs9301653 Imputed T DOM 682 3 37 260 7 86 289 rs9309988 Imputed G DOM 682 2 64 234 6 49 327 rs9309989 Genotyped C DOM 682 2 66 232 8 48 326 rs9310221 Imputed A DOM 631 50 161 71 65 141 143 rs9327555 Imputed T DOM 682 36 113 151 45 199 138 rs937890 Imputed G DOM 638 8 55 218 6 102 249 rs9454967 Imputed G ADD 678 3 62 234 3 41 335 rs9454967 Imputed G DOM 678 3 62 234 3 41 335 rs9471295 Imputed T DOM 682 5 90 205 4 86 292 rs9477007 Imputed A ADD 651 65 136 85 52 164 149 rs9477007 Imputed A GEN 651 65 136 85 52 164 149 rs9487279 Imputed T DOM 653 45 118 126 62 187 115 rs949016 Imputed C ADD 682 29 125 146 18 133 231 rs9555973 Imputed G ADD 681 3 41 256 8 88 285 rs9555973 Imputed G DOM 681 3 41 256 8 88 285 rs9557510 Imputed G ADD 680 6 91 202 6 76 299 rs9557510 Imputed G DOM 680 6 91 202 6 76 299 rs9560584 Imputed T DOM 660 3 37 251 7 83 279 rs9588770 Imputed T DOM 680 3 42 255 8 86 286 rs9588848 Imputed C ADD 682 3 37 260 7 86 289 rs9588848 Imputed C DOM 682 3 37 260 7 86 289 rs966583 Imputed A ADD 679 45 127 126 65 198 118 rs966583 Imputed A DOM 679 45 127 126 65 198 118 rs974130 Genotyped A REC 682 52 117 131 39 187 156 rs977160 Imputed T ADD 681 26 130 144 17 125 239 rs9812206 Imputed G ADD 682 1 36 263 6 82 294 rs9812206 Imputed G DOM 682 1 36 263 6 82 294 rs9813552 Imputed G ADD 673 1 36 261 5 82 288 rs9813552 Imputed G DOM 673 1 36 261 5 82 288 rs9815037 Imputed T ADD 682 1 36 263 5 83 294 rs9815037 Imputed T DOM 682 1 36 263 5 83 294 rs9825349 Imputed A ADD 682 1 36 263 5 83 294 rs9825349 Imputed A DOM 682 1 36 263 5 83 294 rs9834217 Imputed T ADD 681 1 36 262 5 83 294 rs9834217 Imputed T DOM 681 1 36 262 5 83 294 rs9840460 Imputed T ADD 682 1 36 263 5 83 294 rs9840460 Imputed T DOM 682 1 36 263 5 83 294 rs9840756 Imputed A ADD 682 1 36 263 5 83 294 rs9840756 Imputed A DOM 682 1 36 263 5 83 294 rs9844801 Imputed C DOM 682 2 64 234 6 49 327 rs985375 Imputed A GEN 655 30 110 146 16 131 222 rs9869187 Imputed C ADD 681 0 35 264 6 74 302 rs9869187 Imputed C DOM 681 0 35 264 6 74 302 rs9872327 Imputed T DOM 682 2 64 234 6 49 327 rs9881685 Imputed A ADD 682 1 36 263 6 82 294 rs9881685 Imputed A DOM 682 1 36 263 6 82 294 rs9909499 Imputed C DOM 668 29 136 132 29 146 196 rs9911847 Imputed G DOM 680 9 58 233 6 107 267 rs9946886 Imputed G REC 232 13 61 35 40 41 42 rs9958823 Imputed A ADD 679 30 125 144 18 133 229 rs9965248 Imputed T ADD 671 27 128 140 20 128 228

TABLE 10 ALLELE SNP rs # SOURCE (A1) MODEL NMISS OR SE L95 U95 STAT P HW_PVALUE ALLELE_FREQ PRAVA_ALLELE_FREQ PLACEBO_ALLELE_FREQ rs198460 Genotyped G REC 383 2.115 0.2449 1.309 3.418 3.058 0.00223 1 0.48695 0.53145 0.45536 rs603940 Genotyped G REC 383 0.5858 0.2988 0.3261 1.052 −1.79 0.07347 0.7489 0.39687 0.36164 0.42188 rs10021016 Genotyped G GEN 383 3.838 0.1467 0.8921 0.25196 0.28931 0.22545 rs1003148 Imputed C ADD 383 0.7355 0.153 0.545 0.9926 −2.009 0.04457 0.9158 0.4047 0.36164 0.43527 rs1003148 Imputed C GEN 383 4.552 0.1027 0.9158 0.4047 0.36164 0.43527 rs1003148 Imputed C REC 383 0.7366 0.2895 0.4176 1.299 −1.056 0.2911 0.9158 0.4047 0.36164 0.43527 rs10046799 Imputed C ADD 381 0.617 0.1556 0.4548 0.837 −3.103 0.00192 0.7499 0.60105 0.53797 0.64574 rs10046799 Imputed C GEN 381 9.722 0.00774 0.7499 0.60105 0.53797 0.64574 rs10051148 Imputed C DOM 383 0.609 0.2097 0.4037 0.9185 −2.365 0.01802 0.6338 0.3107 0.27358 0.33705 rs10054055 Imputed T DOM 383 0.6113 0.2097 0.4053 0.9221 −2.347 0.01893 0.5542 0.31593 0.27987 0.34152 rs10067895 Imputed A DOM 379 0.6022 0.2112 0.398 0.911 −2.401 0.01634 0.724 0.3219 0.28526 0.34753 rs1008705 Imputed C DOM 276 1.451 0.2489 0.8906 2.363 1.495 0.135 0.3442 0.33514 0.36752 0.31132 rs10105871 Imputed C DOM 355 1.427 0.2237 0.9203 2.212 1.589 0.1121 0.3678 0.37887 0.40203 0.36232 rs10116807 Imputed A GEN 376 4.005 0.135 1 0.20346 0.23077 0.18409 rs10116807 Imputed A REC 376 2.952 0.5596 0.9858 8.84 1.934 0.05307 1 0.20346 0.23077 0.18409 rs10121941 Imputed C DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs10128638 Genotyped G DOM 383 0.6529 0.2374 0.41 1.04 −1.796 0.07252 0.4134 0.50783 0.4717 0.53348 rs1012924 Imputed G ADD 383 0.5758 0.2661 0.3418 0.97 −2.074 0.03805 0.7681 0.09661 0.06918 0.11607 rs1012924 Imputed G DOM 383 0.554 0.2856 0.3166 0.9696 −2.068 0.03864 0.7681 0.09661 0.06918 0.11607 rs1016030 Genotyped G ADD 382 1.554 0.1629 1.129 2.139 2.707 0.0068 0.02038 0.40969 0.46519 0.37054 rs1016030 Genotyped G GEN 382 7.336 0.02553 0.02038 0.40969 0.46519 0.37054 rs1017558 Imputed A REC 382 2.201 0.2868 1.254 3.861 2.75 0.00596 0.8317 0.40052 0.45912 0.35874 rs10183431 Imputed T DOM 383 1.719 0.2141 1.13 2.615 2.53 0.01141 0.6453 0.21149 0.24843 0.18527 rs10195401 Imputed C DOM 377 1.766 0.2208 1.146 2.722 2.575 0.01001 0.00985 0.35544 0.39172 0.32955 rs10239416 Imputed A DOM 381 0.5548 0.2123 0.3659 0.8412 −2.775 0.00553 0.497 0.34646 0.29245 0.38514 rs1032188 Imputed G GEN 381 8.656 0.01319 0.3118 0.28084 0.2327 0.31532 rs1032188 Imputed G REC 381 0.2613 0.4645 0.1051 0.6494 −2.89 0.00386 0.3118 0.28084 0.2327 0.31532 rs10468988 Imputed G ADD 380 1.448 0.1681 1.042 2.013 2.202 0.02767 0.3889 0.29342 0.33228 0.26577 rs10478919 Imputed G DOM 383 0.6113 0.2097 0.4053 0.9221 −2.347 0.01893 0.4104 0.31723 0.28302 0.34152 rs10506623 Imputed C DOM 383 0.6268 0.2197 0.4075 0.9641 −2.126 0.03347 0.133 0.39034 0.34591 0.42188 rs10506626 Imputed A DOM 371 0.5858 0.2268 0.3756 0.9138 −2.358 0.0184 0.0525 0.40296 0.35526 0.43607 rs10509477 Imputed T DOM 383 1.367 0.2096 0.9065 2.062 1.491 0.1358 0.4613 0.29373 0.31761 0.27679 rs10511071 Imputed C DOM 383 2.42 0.2725 1.419 4.128 3.244 0.00118 0.3464 0.09138 0.12893 0.06473 rs10511072 Imputed G DOM 383 2.42 0.2725 1.419 4.128 3.244 0.00118 0.3464 0.09138 0.12893 0.06473 rs10511199 Imputed C ADD 379 1.571 0.1825 1.099 2.247 2.475 0.01331 0.3801 0.22559 0.2707 0.19369 rs10513283 Imputed G GEN 383 3.158 0.2061 0.4152 0.19452 0.21384 0.1808 rs10520072 Imputed T DOM 383 0.6021 0.2099 0.3991 0.9085 −2.417 0.01564 0.7244 0.31984 0.28302 0.34598 rs1065639 Imputed C DOM 364 1.785 0.2238 1.151 2.767 2.588 0.00965 0.08775 0.35852 0.40523 0.32464 rs10733846 Imputed G ADD 381 0.6607 0.2049 0.4422 0.9872 −2.023 0.04308 0.3007 0.18241 0.14968 0.20536 rs10733846 Imputed G DOM 381 0.6237 0.2255 0.4009 0.9704 −2.093 0.03632 0.3007 0.18241 0.14968 0.20536 rs10737390 Imputed T DOM 367 0.6571 0.2203 0.4267 1.012 −1.906 0.05666 0.7431 0.39373 0.36218 0.41706 rs10749293 Imputed G DOM 382 1.379 0.2098 0.914 2.08 1.531 0.1257 0.5373 0.29188 0.31761 0.27354 rs10752159 Imputed G DOM 382 1.921 0.2194 1.25 2.953 2.976 0.00292 0.8691 0.19241 0.2327 0.16368 rs10753760 Imputed T ADD 374 1.478 0.1517 1.098 1.99 2.576 0.00999 0.3803 0.37968 0.43506 0.34091 rs10753760 Imputed T GEN 374 6.677 0.0355 0.3803 0.37968 0.43506 0.34091 rs10757887 Imputed C DOM 383 0.5825 0.2158 0.3816 0.8891 −2.505 0.01226 0.1637 0.24021 0.19497 0.27232 rs10758326 Imputed A ADD 382 0.7394 0.1581 0.5424 1.008 −1.91 0.0561 0.2409 0.39921 0.36164 0.42601 rs10758326 Imputed A GEN 382 3.771 0.1518 0.2409 0.39921 0.36164 0.42601 rs10758326 Imputed A REC 382 0.6985 0.3059 0.3835 1.272 −1.173 0.2408 0.2409 0.39921 0.36164 0.42601 rs10762236 Genotyped G ADD 383 0.6676 0.2037 0.4479 0.9952 −1.984 0.04728 0.233 0.18277 0.15094 0.20536 rs10765769 Imputed C ADD 378 1.537 0.1636 1.115 2.118 2.627 0.00862 0.01547 0.42725 0.48089 0.38914 rs10765769 Imputed C GEN 378 6.932 0.03125 1.55E−02 0.42725 0.48089 0.38914 rs10784891 Imputed C ADD 372 0.7477 0.1606 0.5458 1.024 −1.811 0.07022 0.2351 0.40188 0.36129 0.43088 rs10784891 Imputed C DOM 372 0.5753 0.2241 0.3708 0.8925 −2.467 0.01361 0.2351 0.40188 0.36129 0.43088 rs10787923 Imputed G DOM 383 1.391 0.2096 0.9222 2.098 1.574 0.1155 0.5365 0.29112 0.31761 0.27232 rs10787949 Imputed A DOM 382 1.33 0.2097 0.8818 2.006 1.36 0.1737 0.5395 0.29581 0.32075 0.27803 rs10787951 Imputed G DOM 382 1.33 0.2097 0.8818 2.006 1.36 0.1737 0.5395 0.29581 0.32075 0.27803 rs10787983 Imputed C DOM 382 1.351 0.2099 0.8952 2.038 1.432 0.152 0.4588 0.29319 0.31646 0.27679 rs10788380 Imputed C ADD 377 1.299 0.1485 0.9713 1.738 1.764 0.07781 0.6046 0.53581 0.57643 0.50682 rs10788380 Imputed C DOM 377 1.624 0.2633 0.9695 2.721 1.842 0.06541 0.6046 0.53581 0.57643 0.50682 rs10788380 Imputed C GEN 377 3.622 0.1635 0.6046 0.53581 0.57643 0.50682 rs10814418 Imputed G DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs10831417 Imputed A ADD 383 1.615 0.1632 1.173 2.224 2.937 0.00332 0.02621 0.40862 0.46855 0.36607 rs10831417 Imputed A GEN 383 8.69 0.01297 0.02621 0.40862 0.46855 0.36607 rs10831422 Imputed C ADD 378 1.53 0.1629 1.112 2.106 2.611 0.00902 0.03304 0.40212 0.4557 0.36364 rs10831422 Imputed C GEN 378 7.075 0.02908 0.03304 0.40212 0.4557 0.36364 rs10862931 Imputed C GEN 377 3.939 0.1395 0.4279 0.34748 0.30645 0.37613 rs10865197 Imputed C DOM 383 1.719 0.2141 1.13 2.615 2.53 0.01141 0.6453 0.21149 0.24843 0.18527 rs10871302 Imputed A DOM 382 1.272 0.2475 0.7828 2.066 0.9709 0.3316 0.8085 0.12042 0.13836 0.10762 rs10877463 Imputed C DOM 381 0.5962 0.213 0.3927 0.9052 −2.428 0.0152 0.424 0.3399 0.30063 0.36771 rs10877468 Imputed C DOM 375 0.5825 0.2147 0.3824 0.8872 −2.518 0.01181 0.4237 0.34133 0.3 0.37045 rs10879240 Imputed C ADD 383 0.7632 0.1542 0.5641 1.032 −1.753 0.07966 0.6 0.41775 0.37736 0.44643 rs10879242 Imputed A DOM 383 0.643 0.2198 0.418 0.9893 −2.009 0.04455 0.1989 0.39426 0.3522 0.42411 rs10879245 Imputed G DOM 383 0.643 0.2198 0.418 0.9893 −2.009 0.04455 0.1989 0.39426 0.3522 0.42411 rs10879249 Imputed T DOM 383 0.6376 0.2187 0.4154 0.9789 −2.057 0.03964 0.1621 0.38903 0.34591 0.41964 rs10886452 Imputed A DOM 382 1.33 0.2097 0.8818 2.006 1.36 0.1737 0.5395 0.29581 0.32075 0.27803 rs10886463 Imputed C DOM 381 1.346 0.21 0.8919 2.032 1.415 0.157 0.3912 0.29659 0.32075 0.27928 rs10886465 Imputed A DOM 383 1.341 0.2095 0.8897 2.022 1.402 0.161 0.3936 0.29634 0.32075 0.27902 rs10886526 Imputed C DOM 381 1.361 0.21 0.9017 2.054 1.467 0.1423 0.3889 0.29265 0.31646 0.27578 rs10902437 Imputed G ADD 355 1.176 0.1625 0.8556 1.618 1 0.3172 0.1268 0.41972 0.44257 0.40338 rs10941126 Imputed G ADD 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs10941126 Imputed G DOM 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs10947871 Imputed A DOM 383 1.488 0.2326 0.9435 2.348 1.71 0.08731 0.5442 0.14883 0.16667 0.13616 rs10972978 Imputed G DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs10973012 Imputed A DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs10974028 Genotyped G ADD 383 0.6345 0.2091 0.4211 0.956 −2.175 0.02963 0.5604 0.15666 0.12264 0.1808 rs10974028 Genotyped G DOM 383 0.5711 0.2392 0.3573 0.9127 −2.342 0.01918 0.5604 0.15666 0.12264 0.1808 rs11021302 Imputed A ADD 378 1.53 0.1629 1.112 2.106 2.611 0.00902 0.03304 0.40212 0.4557 0.36364 rs11021302 Imputed A GEN 378 7.075 0.02908 0.03304 0.40212 0.4557 0.36364 rs11099644 Imputed G REC 382 2.201 0.2868 1.254 3.861 2.75 0.00596 0.8317 0.40052 0.45912 0.35874 rs11138315 Imputed G ADD 364 0.5496 0.2588 0.3309 0.9128 −2.313 0.02075 0.4098 0.10852 0.07566 0.13208 rs11149802 Imputed T DOM 382 1.272 0.2475 0.7828 2.066 0.9709 0.3316 0.8085 0.12042 0.13836 0.10762 rs1116596 Imputed T DOM 383 0.6113 0.2097 0.4053 0.9221 −2.347 0.01893 0.4104 0.31723 0.28302 0.34152 rs11178531 Imputed A ADD 381 0.778 0.1538 0.5755 1.052 −1.632 0.1027 0.5321 0.42913 0.39172 0.45536 rs11178531 Imputed A DOM 381 0.5967 0.2247 0.3841 0.9269 −2.298 0.02156 0.5321 0.42913 0.39172 0.45536 rs11178575 Imputed C GEN 382 2.149 0.3415 0.6639 0.37696 0.39937 0.36099 rs11178575 Imputed C REC 382 1.549 0.3014 0.8578 2.796 1.451 0.1468 0.6639 0.37696 0.39937 0.36099 rs11178577 Imputed T GEN 383 2.22 0.3296 0.6635 0.37728 0.39937 0.36161 rs11178577 Imputed T REC 383 1.557 0.3014 0.8625 2.811 1.469 0.1418 0.6635 0.37728 0.39937 0.36161 rs11178583 Imputed A DOM 383 0.6376 0.2187 0.4154 0.9789 −2.057 0.03964 0.1621 0.38903 0.34591 0.41964 rs11178589 Imputed T DOM 382 0.6428 0.2192 0.4183 0.9878 −2.016 0.0438 0.1627 0.38874 0.34591 0.41928 rs11178594 Imputed C DOM 383 0.6253 0.2193 0.4068 0.9611 −2.141 0.0323 0.133 0.39034 0.34591 0.42188 rs11178602 Imputed T DOM 383 0.6388 0.2189 0.4159 0.9811 −2.047 0.04066 0.1621 0.38903 0.34591 0.41964 rs11178648 Imputed T DOM 382 0.5988 0.2187 0.3901 0.9193 −2.345 0.01904 0.2351 0.38613 0.33861 0.41964 rs11198877 Imputed T DOM 382 1.33 0.2097 0.8818 2.006 1.36 0.1737 0.5395 0.29581 0.32075 0.27803 rs11198942 Imputed T DOM 383 1.367 0.2096 0.9065 2.062 1.491 0.1358 0.4613 0.29373 0.31761 0.27679 rs11221075 Imputed A ADD 378 0.7098 0.2323 0.4502 1.119 −1.475 0.1401 1 0.12434 0.1051 0.13801 rs11242020 Imputed T DOM 382 0.6024 0.2102 0.399 0.9096 −2.411 0.01591 0.4079 0.31675 0.28165 0.34152 rs11242021 Imputed T DOM 381 0.602 0.2105 0.3986 0.9094 −2.411 0.01591 0.7248 0.32152 0.28481 0.34753 rs11242022 Imputed T DOM 380 0.617 0.2103 0.4086 0.9318 −2.296 0.02168 1 0.31316 0.27987 0.3371 rs11242023 Imputed T DOM 379 0.6116 0.2108 0.4046 0.9244 −2.333 0.01964 0.7243 0.31926 0.28481 0.34389 rs1149350 Imputed A DOM 382 1.97 0.2254 1.266 3.065 3.007 0.00264 0.05226 0.17801 0.22327 0.14574 rs1150143 Imputed G DOM 379 1.782 0.2127 1.175 2.704 2.717 0.00659 0.128 0.32586 0.38217 0.28604 rs11576627 Imputed T ADD 383 1.437 0.2014 0.9684 2.132 1.8 0.0718 0.2168 0.14491 0.17296 0.125 rs11576627 Imputed T DOM 383 1.496 0.2351 0.9433 2.371 1.712 0.08693 0.2168 0.14491 0.17296 0.125 rs11602189 Imputed A DOM 374 0.5948 0.2142 0.3909 0.905 −2.426 0.01527 1 0.31818 0.27124 0.35068 rs11605163 Imputed A DOM 376 2.186 0.3185 1.171 4.08 2.455 0.01408 0.3822 0.0625 0.08654 0.04545 rs11615214 Imputed G ADD 382 0.7639 0.1532 0.5657 1.032 −1.758 0.07882 1 0.38874 0.35127 0.41518 rs11615214 Imputed G GEN 382 3.652 0.161 1 0.38874 0.35127 0.41518 rs11642394 Imputed C DOM 383 1.277 0.2476 0.7859 2.074 0.9866 0.3238 0.8082 0.1201 0.13836 0.10714 rs11644943 Imputed A ADD 380 1.606 0.1767 1.136 2.27 2.68 0.00736 0.7774 0.23816 0.28616 0.20362 rs11656608 Imputed T DOM 383 0.7037 0.2279 0.4502 1.1 −1.542 0.1231 0.8589 0.17363 0.15409 0.1875 rs11661309 Imputed A ADD 383 0.5977 0.199 0.4046 0.8827 −2.587 0.00969 0.1541 0.17493 0.13208 0.20536 rs11661309 Imputed A DOM 383 0.5564 0.2336 0.352 0.8796 −2.509 0.0121 0.1541 0.17493 0.13208 0.20536 rs11666131 Imputed A ADD 382 1.578 0.1755 1.119 2.226 2.6 0.00931 0.2905 0.21466 0.26266 0.1808 rs11743355 Imputed C ADD 379 0.2291 0.7784 0.04984 1.054 −1.893 0.05836 1 0.01715 0.00629 0.025 rs11743355 Imputed C DOM 379 0.2291 0.7784 0.04984 1.054 −1.893 0.05836 1 0.01715 0.00629 0.025 rs11746806 Imputed T ADD 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs11746806 Imputed T DOM 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs11746959 Imputed T ADD 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs11746959 Imputed T DOM 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs11749272 Imputed T DOM 383 0.6113 0.2097 0.4053 0.9221 −2.347 0.01893 0.4104 0.31723 0.28302 0.34152 rs11901899 Imputed A DOM 378 1.83 0.2121 1.208 2.774 2.851 0.00436 0.1985 0.27646 0.33333 0.23649 rs11926319 Imputed G ADD 380 0.3536 0.2967 0.1977 0.6325 −3.504 0.00046 1 0.09868 0.05414 0.13004 rs11926319 Imputed G DOM 380 0.3514 0.3031 0.194 0.6364 −3.451 0.00056 1 0.09868 0.05414 0.13004 rs11956952 Imputed C DOM 378 0.7003 0.2121 0.4621 1.061 −1.679 0.09313 0.2413 0.26984 0.25478 0.28054 rs12025826 Imputed G DOM 377 1.354 0.2159 0.8867 2.067 1.403 0.1607 0.1274 0.38462 0.39809 0.375 rs1204522 Imputed C GEN 378 3.915 0.1412 0.58 0.36243 0.32595 0.38864 rs1204524 Imputed A GEN 378 3.758 0.1527 0.5784 0.36376 0.32803 0.38914 rs12153185 Imputed T DOM 379 0.6022 0.2112 0.398 0.911 −2.401 0.01634 0.724 0.3219 0.28526 0.34753 rs12182651 Imputed T ADD 382 2.387 0.3056 1.311 4.345 2.847 0.00442 0.1765 0.06283 0.09494 0.04018 rs12182651 Imputed T DOM 382 2.904 0.3322 1.514 5.569 3.209 0.00133 0.1765 0.06283 0.09494 0.04018 rs12193568 Imputed G DOM 237 2.406 0.3051 1.323 4.375 2.878 0.00401 0.2704 0.13713 0.18557 0.10357 rs12264914 Imputed C DOM 204 0.7523 0.29 0.4261 1.328 −0.9814 0.3264 0.7359 0.29167 0.2625 0.31048 rs12307767 Imputed C DOM 352 0.5633 0.2206 0.3656 0.868 −2.602 0.00928 0.4648 0.32102 0.27931 0.35024 rs1232298 Imputed G REC 372 2.839 0.3328 1.479 5.45 3.135 0.00172 0.2379 0.32661 0.37742 0.29032 rs12407412 Imputed C ADD 383 1.437 0.2014 0.9684 2.132 1.8 0.0718 0.2168 0.14491 0.17296 0.125 rs12407412 Imputed C DOM 383 1.496 0.2351 0.9433 2.371 1.712 0.08693 0.2168 0.14491 0.17296 0.125 rs12420184 Imputed G DOM 382 0.6069 0.2381 0.3805 0.9678 −2.097 0.03596 0.1285 0.16099 0.1195 0.19058 rs12422750 Imputed A DOM 383 0.5915 0.2116 0.3907 0.8956 −2.481 0.0131 0.2019 0.32637 0.28616 0.35491 rs12446951 Imputed A ADD 266 3.123 0.3652 1.526 6.388 3.118 0.00182 0.1047 0.06767 0.11429 0.03727 rs12446951 Imputed A DOM 266 3.166 0.3883 1.479 6.776 2.968 0.003 0.1047 0.06767 0.11429 0.03727 rs12457400 Imputed G DOM 383 0.6578 0.2682 0.3889 1.113 −1.562 0.1183 0.7834 0.10444 0.08491 0.1183 rs1247340 Imputed C DOM 383 1.98 0.2254 1.273 3.079 3.03 0.00244 0.07793 0.17624 0.22327 0.14286 rs1247341 Imputed C DOM 382 2.017 0.2261 1.295 3.142 3.103 0.00192 0.07501 0.17539 0.22327 0.14126 rs12521291 Imputed G ADD 380 0.6882 0.1569 0.506 0.9361 −2.381 0.01727 0.6567 0.35921 0.3121 0.39238 rs12526849 Imputed T ADD 380 1.357 0.1432 1.025 1.797 2.132 0.03298 0.04681 0.42763 0.47484 0.39367 rs12526849 Imputed T GEN 380 5.531 0.06295 0.04681 0.42763 0.47484 0.39367 rs12543110 Imputed G DOM 383 1.832 0.2138 1.205 2.786 2.832 0.00463 0.4624 0.22454 0.28302 0.18304 rs12678600 Imputed A DOM 381 0.5988 0.211 0.396 0.9055 −2.43 0.01509 0.9081 0.33202 0.28616 0.36486 rs12719415 Imputed T DOM 383 0.6021 0.2099 0.3991 0.9085 −2.417 0.01564 0.7244 0.31984 0.28302 0.34598 rs12831292 Imputed G DOM 382 0.643 0.219 0.4186 0.9878 −2.016 0.04381 0.1627 0.38874 0.34591 0.41928 rs12923993 Imputed C DOM 383 1.277 0.2476 0.7859 2.074 0.9866 0.3238 0.8082 0.1201 0.13836 0.10714 rs12936964 Imputed T DOM 380 1.581 0.2211 1.025 2.439 2.073 0.03817 0.3863 0.38553 0.40823 0.36937 rs12960663 Imputed G ADD 383 0.5977 0.199 0.4046 0.8827 −2.587 0.00969 0.1541 0.17493 0.13208 0.20536 rs13038146 Imputed C ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs13038146 Imputed C GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs13134222 Imputed A GEN 382 6.996 0.03026 0.1929 0.23037 0.18553 0.26233 rs13172910 Imputed A DOM 379 0.6946 0.212 0.4585 1.052 −1.719 0.08561 0.2969 0.27045 0.25478 0.28153 rs13194907 Imputed A ADD 383 2.378 0.3248 1.258 4.495 2.668 0.00763 1 0.05744 0.08491 0.03795 rs13194907 Imputed A DOM 383 2.64 0.3358 1.367 5.099 2.891 0.00384 1 0.05744 0.08491 0.03795 rs13195745 Imputed A ADD 383 2.378 0.3248 1.258 4.495 2.668 0.00763 1 0.05744 0.08491 0.03795 rs13195745 Imputed A DOM 383 2.64 0.3358 1.367 5.099 2.891 0.00384 1 0.05744 0.08491 0.03795 rs1321432 Imputed A REC 383 1.784 0.3115 0.9689 3.286 1.859 0.0631 0.3248 0.37206 0.39308 0.35714 rs1321457 Imputed G REC 383 1.704 0.3084 0.9308 3.118 1.728 0.08407 0.6599 0.36684 0.38679 0.35268 rs13265054 Imputed T DOM 381 0.5995 0.211 0.3965 0.9065 −2.425 0.01529 0.9081 0.33202 0.28616 0.36486 rs13282131 Imputed C GEN 383 4.029 0.1334 0.3575 0.4752 0.51887 0.4442 rs13353526 Imputed C DOM 383 2.299 0.2671 1.362 3.881 3.116 0.00183 0.2304 0.0953 0.13208 0.0692 rs1336382 Imputed T DOM 383 1.367 0.2096 0.9065 2.062 1.491 0.1358 0.4613 0.29373 0.31761 0.27679 rs1336383 Imputed T DOM 383 1.367 0.2096 0.9065 2.062 1.491 0.1358 0.4613 0.29373 0.31761 0.27679 rs1336407 Imputed T DOM 383 1.367 0.2096 0.9065 2.062 1.491 0.1358 0.4613 0.29373 0.31761 0.27679 rs1336409 Imputed T DOM 382 1.355 0.2098 0.8985 2.045 1.45 0.1471 0.4624 0.2945 0.31761 0.27803 rs1336596 Imputed A DOM 380 0.6528 0.2133 0.4297 0.9916 −2 0.04554 0.2643 0.35658 0.32595 0.37838 rs1343560 Imputed T ADD 383 0.5758 0.2661 0.3418 0.97 −2.074 0.03805 0.7681 0.09661 0.06918 0.11607 rs1343560 Imputed T DOM 383 0.554 0.2856 0.3166 0.9696 −2.068 0.03864 0.7681 0.09661 0.06918 0.11607 rs1361987 Imputed T GEN 383 3.272 0.1948 0.4362 0.3577 0.3239 0.3817 rs1386153 Imputed T ADD 379 0.6655 0.164 0.4826 0.9177 −2.484 0.01299 0.8128 0.31662 0.26752 0.35135 rs1386153 Imputed T DOM 379 0.5913 0.212 0.3902 0.8959 −2.478 0.01321 0.8128 0.31662 0.26752 0.35135 rs1394015 Imputed C DOM 356 1.898 0.243 1.179 3.056 2.637 0.00837 0.08154 0.41854 0.47569 0.37972 rs1407038 Imputed A REC 382 1.717 0.3085 0.9381 3.144 1.753 0.07963 0.6601 0.36649 0.38608 0.35268 rs1407039 Imputed A REC 379 1.715 0.3088 0.9365 3.142 1.748 0.08054 0.5818 0.37071 0.38854 0.35811 rs1412802 Imputed T GEN 381 5.343 0.06914 0.3707 0.27428 0.2327 0.30405 rs1414865 Imputed T DOM 382 1.33 0.2097 0.8818 2.006 1.36 0.1737 0.5395 0.29581 0.32075 0.27803 rs1414873 Imputed A DOM 383 1.367 0.2096 0.9065 2.062 1.491 0.1358 0.4613 0.29373 0.31761 0.27679 rs1414876 Imputed C DOM 383 1.367 0.2096 0.9065 2.062 1.491 0.1358 0.4613 0.29373 0.31761 0.27679 rs1418671 Imputed C REC 377 2.067 0.2706 1.216 3.513 2.684 0.00728 0.8338 0.43236 0.4557 0.41553 rs1419490 Genotyped T GEN 383 3.125 0.2096 0.4381 0.3564 0.3239 0.37946 rs1434507 Imputed A ADD 381 1.405 0.1664 1.014 1.947 2.044 0.04098 0.5376 0.29396 0.33019 0.26802 rs1434508 Imputed T ADD 382 1.399 0.1663 1.01 1.938 2.018 0.04355 0.5378 0.2945 0.33019 0.26906 rs1435205 Imputed A ADD 379 1.571 0.1825 1.099 2.247 2.475 0.01331 0.3801 0.22559 0.2707 0.19369 rs1443928 Imputed C REC 380 0.5055 0.2469 0.3116 0.8201 −2.763 0.00572 0.5394 0.51579 0.43671 0.57207 rs1452235 Imputed G GEN 383 4.025 0.1337 0.3156 0.35248 0.31132 0.3817 rs1452236 Imputed G GEN 383 4.025 0.1337 0.3156 0.35248 0.31132 0.3817 rs1452237 Imputed G GEN 383 4.025 0.1337 0.3156 0.35248 0.31132 0.3817 rs1452243 Genotyped T GEN 383 4.025 0.1337 0.3156 0.35248 0.31132 0.3817 rs1463768 Genotyped G REC 383 2.557 0.2969 1.429 4.574 3.162 0.00157 0.6662 0.38251 0.41195 0.36161 rs1463769 Imputed G REC 383 2.557 0.2969 1.429 4.574 3.162 0.00157 0.6662 0.38251 0.41195 0.36161 rs1472435 Imputed A ADD 374 0.3624 0.3387 0.1866 0.704 −2.996 0.00274 0.2433 0.07353 0.0414 0.09677 rs1472435 Imputed A DOM 374 0.3624 0.3387 0.1866 0.704 −2.996 0.00274 0.2433 0.07353 0.0414 0.09677 rs1476714 Imputed A DOM 381 0.5994 0.2104 0.3969 0.9054 −2.432 0.01501 0.6369 0.3189 0.28165 0.34529 rs1495159 Imputed G ADD 377 0.6292 0.1647 0.4556 0.8688 −2.814 0.0049 0.01409 0.27454 0.21935 0.31306 rs1495159 Imputed G GEN 377 8.035 0.018 0.01409 0.27454 0.21935 0.31306 rs1495375 Imputed A DOM 383 0.643 0.2198 0.418 0.9893 −2.009 0.04455 0.1989 0.39426 0.3522 0.42411 rs1495376 Imputed T DOM 371 0.4469 0.2418 0.2782 0.7178 −3.331 0.00086 0.7551 0.47844 0.43182 0.51152 rs1495377 Imputed G DOM 370 0.4491 0.2417 0.2797 0.7213 −3.312 0.00093 0.7556 0.47838 0.43182 0.51157 rs1495381 Imputed T GEN 383 5.394 0.06741 0.7553 0.43473 0.46541 0.41295 rs1495381 Imputed T REC 383 1.786 0.2638 1.065 2.996 2.199 0.02786 0.7553 0.43473 0.46541 0.41295 rs1498992 Imputed G DOM 383 0.6967 0.2093 0.4622 1.05 −1.727 0.08421 0.5379 0.29373 0.27358 0.30804 rs1499001 Imputed T DOM 378 0.6855 0.2116 0.4528 1.038 −1.784 0.07436 0.352 0.2619 0.24214 0.27626 rs1512988 Imputed A DOM 380 0.6145 0.2204 0.3989 0.9466 −2.209 0.02719 0.161 0.39079 0.34494 0.42342 rs1512989 Imputed T DOM 380 0.6145 0.2204 0.3989 0.9466 −2.209 0.02719 0.161 0.39079 0.34494 0.42342 rs1512991 Imputed T ADD 382 0.7489 0.1551 0.5526 1.015 −1.864 0.06235 0.5292 0.41623 0.37342 0.44643 rs1512991 Imputed T DOM 382 0.571 0.2227 0.3691 0.8835 −2.516 0.01186 0.5292 0.41623 0.37342 0.44643 rs1516855 Imputed G REC 382 2.635 0.3326 1.373 5.056 2.913 0.00358 0.3164 0.35864 0.38679 0.33857 rs1527450 Imputed T ADD 383 1.615 0.1632 1.173 2.224 2.937 0.00332 0.02621 0.40862 0.46855 0.36607 rs1527450 Imputed T GEN 383 8.69 0.01297 0.02621 0.40862 0.46855 0.36607 rs1567740 Imputed T DOM 381 0.6186 0.2199 0.402 0.9518 −2.185 0.02891 0.1327 0.39108 0.34591 0.42342 rs1572573 Imputed A ADD 362 1.424 0.201 0.9603 2.112 1.759 0.07865 0.2969 0.18646 0.21622 0.16589 rs1572573 Imputed A DOM 362 1.608 0.2249 1.035 2.498 2.112 0.03472 0.2969 0.18646 0.21622 0.16589 rs1584003 Imputed C DOM 380 1.619 0.2537 0.9846 2.661 1.899 0.05761 0.3047 0.49605 0.52548 0.47534 rs1584005 Imputed C DOM 380 1.619 0.2537 0.9846 2.661 1.899 0.05761 0.3047 0.49605 0.52548 0.47534 rs1585771 Imputed G ADD 382 1.485 0.1701 1.064 2.073 2.325 0.02005 0.44 0.27225 0.31646 0.24107 rs1592015 Imputed G DOM 383 0.6821 0.2397 0.4264 1.091 −1.596 0.1105 0.3197 0.15013 0.12579 0.16741 rs1594885 Imputed A ADD 380 1.429 0.1671 1.03 1.983 2.138 0.03253 0.461 0.29737 0.33544 0.27027 rs1603232 Imputed A DOM 370 0.4692 0.2395 0.2935 0.7503 −3.159 0.00158 0.8353 0.47432 0.43137 0.50461 rs1614565 Imputed C DOM 372 0.4727 0.2424 0.2939 0.7602 −3.091 0.00199 0.6778 0.48253 0.44156 0.51147 rs1648200 Imputed G ADD 363 1.513 0.1861 1.05 2.179 2.224 0.02618 0.02626 0.25207 0.29333 0.223 rs16877387 Imputed C GEN 382 6.901 0.03174 0.8277 0.37304 0.40506 0.35045 rs16877387 Imputed C REC 382 2.182 0.3041 1.202 3.961 2.566 0.01029 0.8277 0.37304 0.40506 0.35045 rs16938626 Imputed G DOM 382 0.5784 0.2111 0.3825 0.8747 −2.594 0.00948 0.5218 0.27618 0.23101 0.30804 rs1694334 Imputed G ADD 351 0.6042 0.1961 0.4114 0.8874 −2.569 0.01019 0.7491 0.21225 0.16443 0.24752 rs16998821 Imputed C DOM 383 0.6821 0.2397 0.4264 1.091 −1.596 0.1105 0.3197 0.15013 0.12579 0.16741 rs1700400 Imputed T ADD 362 0.5776 0.1758 0.4093 0.8151 −3.123 0.00179 0.05211 0.25552 0.19156 0.30288 rs17007620 Imputed G ADD 363 1.653 0.1777 1.167 2.341 2.828 0.00468 1 0.24656 0.3 0.20892 rs17007620 Imputed G DOM 363 1.767 0.2175 1.154 2.707 2.619 0.00883 1 0.24656 0.3 0.20892 rs17023290 Imputed C DOM 383 2.42 0.2725 1.419 4.128 3.244 0.00118 0.3464 0.09138 0.12893 0.06473 rs17047957 Imputed C DOM 383 1.726 0.2428 1.073 2.778 2.249 0.02453 0.4928 0.12924 0.16352 0.10491 rs1705237 Imputed A DOM 369 0.4663 0.2431 0.2895 0.7508 −3.139 0.0017 0.7547 0.48238 0.44079 0.51152 rs1705261 Imputed A GEN 383 5.394 0.06741 0.7553 0.43473 0.46541 0.41295 rs1705261 Imputed A REC 383 1.786 0.2638 1.065 2.996 2.199 0.02786 0.7553 0.43473 0.46541 0.41295 rs17076972 Imputed C ADD 383 1.44 0.1509 1.071 1.935 2.416 0.01568 0.7591 0.46736 0.51887 0.4308 rs17076972 Imputed C GEN 383 6.553 0.03777 0.7591 0.46736 0.51887 0.4308 rs17076972 Imputed C REC 383 1.85 0.2521 1.128 3.032 2.439 0.01473 0.7591 0.46736 0.51887 0.4308 rs17189710 Imputed T ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs17189710 Imputed T GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs17196143 Imputed A ADD 383 1.543 0.1879 1.068 2.231 2.308 0.02098 0.869 0.1893 0.22956 0.16071 rs17353809 Imputed G ADD 382 1.616 0.1806 1.134 2.302 2.658 0.00786 0.3892 0.23037 0.27848 0.19643 rs17368986 Imputed A GEN 381 3.069 0.2155 0.4122 0.19423 0.21384 0.18018 rs17369097 Imputed A GEN 383 4.104 0.1285 0.3319 0.19713 0.21698 0.18304 rs17434511 Imputed C GEN 383 3.158 0.2061 0.4152 0.19452 0.21384 0.1808 rs17434589 Imputed C GEN 376 3.386 0.184 0.4114 0.19548 0.2129 0.18326 rs17434603 Imputed G GEN 383 3.158 0.2061 0.4152 0.19452 0.21384 0.1808 rs17434840 Imputed C GEN 383 4.104 0.1285 0.3319 0.19713 0.21698 0.18304 rs17446418 Imputed G DOM 382 0.6878 0.2135 0.4526 1.045 −1.753 0.07956 0.7451 0.38089 0.34906 0.40359 rs17530747 Imputed T DOM 382 0.6878 0.2135 0.4526 1.045 −1.753 0.07956 0.7451 0.38089 0.34906 0.40359 rs17604285 Imputed C ADD 383 0.4148 0.2819 0.2387 0.7208 −3.122 0.0018 0.4026 0.10183 0.06289 0.12946 rs17604285 Imputed C DOM 383 0.4153 0.2867 0.2368 0.7285 −3.065 0.00218 0.4026 0.10183 0.06289 0.12946 rs17662322 Imputed T DOM 383 0.6835 0.2193 0.4447 1.05 −1.735 0.08267 0.526 0.19974 0.17296 0.21875 rs17769826 Imputed T ADD 382 1.616 0.1806 1.134 2.302 2.658 0.00786 0.3892 0.23037 0.27848 0.19643 rs17821641 Imputed T ADD 379 1.571 0.1825 1.099 2.247 2.475 0.01331 0.3801 0.22559 0.2707 0.19369 rs1782328 Imputed A ADD 356 0.5789 0.2144 0.3803 0.8814 −2.549 0.0108 0.4722 0.17978 0.13667 0.21117 rs1796337 Imputed T DOM 379 0.5422 0.239 0.3394 0.8661 −2.561 0.01043 0.8372 0.49208 0.44937 0.52262 rs1798083 Imputed C DOM 370 0.4733 0.2427 0.2942 0.7617 −3.081 0.00206 0.6044 0.48108 0.43791 0.51152 rs1798085 Imputed T DOM 372 0.4727 0.2424 0.2939 0.7602 −3.091 0.00199 0.6778 0.48253 0.44156 0.51147 rs1798086 Imputed T DOM 370 0.4689 0.2427 0.2914 0.7545 −3.12 0.00181 0.7547 0.48243 0.44118 0.51152 rs1798089 Imputed C GEN 371 5.637 0.0597 0.2536 0.469 0.51316 0.43836 rs1798089 Imputed C REC 371 1.806 0.2499 1.106 2.947 2.365 0.01804 0.2536 0.469 0.51316 0.43836 rs1798090 Imputed C GEN 371 5.595 0.06097 0.2992 0.47035 0.51645 0.43836 rs1798090 Imputed C REC 371 1.806 0.2499 1.106 2.947 2.365 0.01804 0.2992 0.47035 0.51645 0.43836 rs1832222 Imputed G DOM 382 1.351 0.2099 0.8952 2.038 1.432 0.152 0.4588 0.29319 0.31646 0.27679 rs1838104 Imputed A ADD 370 0.6393 0.1498 0.4766 0.8574 −2.987 0.00282 0.3479 0.52568 0.46104 0.57176 rs1838104 Imputed A GEN 370 11.02 0.00404 0.3479 0.52568 0.46104 0.57176 rs1868616 Imputed G ADD 372 0.7123 0.1959 0.4852 1.046 −1.732 0.08332 0.3379 0.2043 0.17419 0.22581 rs1874313 Imputed A DOM 382 0.6182 0.22 0.4017 0.9516 −2.185 0.02885 0.1324 0.39136 0.34591 0.42377 rs1884902 Imputed C REC 379 1.796 0.3119 0.9747 3.31 1.878 0.0604 0.4419 0.36939 0.38854 0.35586 rs1913201 Imputed G ADD 383 0.7632 0.1542 0.5641 1.032 −1.753 0.07966 0.6 0.41775 0.37736 0.44643 rs1913201 Imputed G DOM 383 0.5772 0.2224 0.3733 0.8926 −2.471 0.01349 0.6 0.41775 0.37736 0.44643 rs1913201 Imputed G GEN 383 6.592 0.03704 0.6 0.41775 0.37736 0.44643 rs1944279 Imputed A ADD 377 1.444 0.1687 1.038 2.01 2.179 0.02933 0.3868 0.29576 0.33439 0.26818 rs198461 Imputed C DOM 382 0.4755 0.245 0.2942 0.7685 −3.035 0.00241 0.9187 0.51309 0.46855 0.54484 rs1987179 Imputed T DOM 383 0.6667 0.216 0.4366 1.018 −1.877 0.06051 0.7691 0.22324 0.20126 0.23884 rs1990023 Imputed T DOM 382 0.6024 0.2102 0.399 0.9096 −2.411 0.01591 0.4079 0.31675 0.28165 0.34152 rs2016194 Imputed G DOM 381 0.602 0.2105 0.3986 0.9094 −2.411 0.01591 0.7248 0.32152 0.28481 0.34753 rs2024789 Imputed C ADD 381 0.7464 0.1501 0.5562 1.002 −1.949 0.05131 0.9185 0.49081 0.44937 0.52018 rs2024789 Imputed C GEN 381 3.798 0.1497 0.9185 0.49081 0.44937 0.52018 rs2024902 Imputed A ADD 382 2.395 0.3248 1.267 4.526 2.688 0.00718 1 0.05759 0.08544 0.03795 rs2024902 Imputed A DOM 382 2.659 0.3358 1.377 5.135 2.912 0.00359 1 0.05759 0.08544 0.03795 rs2025107 Imputed A ADD 382 2.387 0.3056 1.311 4.345 2.847 0.00442 0.1765 0.06283 0.09494 0.04018 rs2025107 Imputed A DOM 382 2.904 0.3322 1.514 5.569 3.209 0.00133 0.1765 0.06283 0.09494 0.04018 rs2025108 Imputed T ADD 382 2.387 0.3056 1.311 4.345 2.847 0.00442 0.1765 0.06283 0.09494 0.04018 rs2025108 Imputed T DOM 382 2.904 0.3322 1.514 5.569 3.209 0.00133 0.1765 0.06283 0.09494 0.04018 rs2062448 Imputed T ADD 383 0.4148 0.2819 0.2387 0.7208 −3.122 0.0018 0.4026 0.10183 0.06289 0.12946 rs2062448 Imputed T DOM 383 0.4153 0.2867 0.2368 0.7285 −3.065 0.00218 0.4026 0.10183 0.06289 0.12946 rs2063591 Imputed C ADD 382 0.7711 0.1536 0.5706 1.042 −1.692 0.09058 0.6013 0.42801 0.38924 0.45536 rs2063591 Imputed C DOM 382 0.5884 0.2242 0.3791 0.9131 −2.366 0.018 0.6013 0.42801 0.38924 0.45536 rs2065604 Imputed C DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs2066238 Imputed T DOM 383 0.6821 0.2397 0.4264 1.091 −1.596 0.1105 0.3197 0.15013 0.12579 0.16741 rs2068051 Imputed G ADD 264 0.6426 0.1952 0.4383 0.9422 −2.265 0.02351 0.06451 0.5 0.45045 0.53595 rs2068051 Imputed G GEN 264 5.343 0.06914 0.06451 0.5 0.45045 0.53595 rs2077702 Genotyped G GEN 383 2.22 0.3296 0.6635 0.37728 0.39937 0.36161 rs208757 Imputed G ADD 345 1.353 0.2024 0.9102 2.012 1.495 0.1348 0.8529 0.17536 0.20139 0.15672 rs208757 Imputed G DOM 345 1.453 0.2347 0.917 2.301 1.591 0.1116 0.8529 0.17536 0.20139 0.15672 rs2095586 Imputed A DOM 382 1.351 0.2099 0.8952 2.038 1.432 0.152 0.4588 0.29319 0.31646 0.27679 rs2108426 Imputed C DOM 381 0.5994 0.2104 0.3969 0.9054 −2.432 0.01501 0.6369 0.3189 0.28165 0.34529 rs2110664 Imputed A DOM 349 1.697 0.2201 1.102 2.613 2.403 0.01627 0.1922 0.28797 0.34028 0.25122 rs2132242 Imputed A DOM 382 0.6291 0.2196 0.4091 0.9676 −2.11 0.03486 0.1617 0.39005 0.34591 0.42152 rs2151644 Imputed T DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs2157752 Genotyped A GEN 383 3.356 0.1868 0.3575 0.3329 0.30189 0.35491 rs2158958 Imputed A DOM 383 0.6021 0.2099 0.3991 0.9085 −2.417 0.01564 0.7244 0.31984 0.28302 0.34598 rs2158961 Imputed G DOM 383 0.6113 0.2097 0.4053 0.9221 −2.347 0.01893 0.5542 0.31593 0.27987 0.34152 rs2164099 Imputed G ADD 382 1.424 0.1667 1.027 1.974 2.121 0.03389 0.4616 0.29581 0.33333 0.26906 rs2173254 Imputed G GEN 381 4.978 0.08298 0.06174 0.32546 0.30063 0.34305 rs2173254 Imputed G REC 381 0.3756 0.4421 0.1579 0.8933 −2.215 0.02675 0.06174 0.32546 0.30063 0.34305 rs2188079 Imputed C ADD 383 1.5 0.1541 1.109 2.029 2.63 0.00854 0.6716 0.40339 0.45912 0.36384 rs2188079 Imputed C GEN 383 6.918 0.03146 0.6716 0.40339 0.45912 0.36384 rs2190304 Imputed G REC 383 0.628 0.2629 0.3751 1.051 −1.77 0.0768 0.47 0.4517 0.43082 0.46652 rs2190597 Imputed T DOM 381 0.7825 0.223 0.5054 1.211 −1.1 0.2713 0.8344 0.43045 0.4172 0.43973 rs2190598 Imputed T DOM 383 0.6021 0.2099 0.3991 0.9085 −2.417 0.01564 0.7244 0.31984 0.28302 0.34598 rs2190600 Imputed A DOM 379 0.6022 0.2112 0.398 0.911 −2.401 0.01634 0.724 0.3219 0.28526 0.34753 rs2218084 Imputed T GEN 383 6.969 0.03066 0.3636 0.16971 0.21069 0.14063 rs2218084 Imputed T REC 383 4.673 0.8259 0.9259 23.58 1.867 0.06194 0.3636 0.16971 0.21069 0.14063 rs2236290 Genotyped C GEN 381 3.686 0.1583 1 0.37664 0.33861 0.40359 rs2243860 Imputed A GEN 306 4.567 0.1019 1 0.35131 0.39431 0.3224 rs2243860 Imputed A REC 306 2.063 0.3516 1.035 4.108 2.059 0.03949 1 0.35131 0.39431 0.3224 rs2246564 Imputed T DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs2248236 Imputed C DOM 383 0.6667 0.216 0.4366 1.018 −1.877 0.06051 0.7691 0.22324 0.20126 0.23884 rs2250340 Imputed T DOM 333 0.4723 0.3046 0.26 0.858 −2.463 0.01378 0.3862 0.10511 0.07299 0.12755 rs2257192 Imputed G DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs2270584 Imputed A DOM 382 0.5988 0.2187 0.3901 0.9193 −2.345 0.01904 0.2351 0.38613 0.33861 0.41964 rs2270586 Imputed A DOM 371 0.5858 0.2268 0.3756 0.9138 −2.358 0.0184 0.0525 0.40296 0.35526 0.43607 rs2270589 Imputed A ADD 308 0.6907 0.1757 0.4895 0.9746 −2.106 0.03518 0.1384 0.4724 0.42188 0.50833 rs2270589 Imputed A DOM 308 0.4396 0.2688 0.2596 0.7445 −3.058 0.00223 0.1384 0.4724 0.42188 0.50833 rs2270589 Imputed A GEN 308 9.89 0.00712 0.1384 0.4724 0.42188 0.50833 rs2296889 Imputed C DOM 381 1.88 0.2321 1.193 2.963 2.721 0.00651 0.6901 0.15223 0.19811 0.11937 rs2301346 Imputed C ADD 343 1.627 0.1791 1.145 2.311 2.717 0.00658 0.2971 0.293 0.34932 0.25127 rs2301346 Imputed C DOM 343 2.008 0.2246 1.293 3.119 3.103 0.00191 0.2971 0.293 0.34932 0.25127 rs2327929 Imputed G REC 383 1.756 0.2541 1.068 2.89 2.217 0.02662 0.8372 0.45431 0.47799 0.4375 rs2357486 Imputed C REC 379 1.682 0.4091 0.7542 3.75 1.27 0.2039 0.00149 0.32322 0.33228 0.31674 rs2373793 Imputed G DOM 374 1.775 0.2221 1.149 2.743 2.583 0.00978 0.6199 0.19251 0.22549 0.16968 rs2377622 Imputed T GEN 283 3.778 0.1513 0.6851 0.32686 0.28205 0.35843 rs2377622 Imputed T REC 283 0.5046 0.4168 0.2229 1.142 −1.641 0.1008 0.6851 0.32686 0.28205 0.35843 rs2383903 Imputed G DOM 381 0.5866 0.211 0.3879 0.8871 −2.528 0.01148 0.444 0.27822 0.23418 0.30942 rs2389866 Imputed C DOM 383 0.6667 0.216 0.4366 1.018 −1.877 0.06051 0.7691 0.22324 0.20126 0.23884 rs2389869 Imputed C DOM 383 0.6667 0.216 0.4366 1.018 −1.877 0.06051 0.7691 0.22324 0.20126 0.23884 rs2418541 Imputed A DOM 383 0.6113 0.2097 0.4053 0.9221 −2.347 0.01893 0.4104 0.31723 0.28302 0.34152 rs2418542 Imputed A DOM 383 0.6113 0.2097 0.4053 0.9221 −2.347 0.01893 0.4104 0.31723 0.28302 0.34152 rs2418548 Imputed C DOM 378 0.6382 0.211 0.4221 0.965 −2.129 0.03326 0.4132 0.32672 0.29618 0.34842 rs2476976 Imputed C DOM 382 1.351 0.2099 0.8952 2.038 1.432 0.152 0.4588 0.29319 0.31646 0.27679 rs2483639 Imputed A DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs2483640 Imputed A DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs2544780 Imputed T REC 381 1.683 0.3502 0.8473 3.344 1.487 0.137 0.7246 0.3189 0.32166 0.31696 rs2586458 Imputed T DOM 323 0.4393 0.2682 0.2597 0.7431 −3.067 0.00216 0.65 0.14396 0.09929 0.17857 rs2593272 Imputed G ADD 383 0.5962 0.1685 0.4285 0.8294 −3.07 0.00214 0.05071 0.26762 0.2044 0.3125 rs2593273 Imputed T ADD 383 0.5962 0.1685 0.4285 0.8294 −3.07 0.00214 0.05071 0.26762 0.2044 0.3125 rs2622499 Imputed G DOM 383 0.6667 0.216 0.4366 1.018 −1.877 0.06051 0.7691 0.22324 0.20126 0.23884 rs264126 Imputed C DOM 381 0.7975 0.2216 0.5165 1.231 −1.022 0.307 1 0.42782 0.4172 0.43527 rs264129 Imputed T DOM 383 0.6113 0.2097 0.4053 0.9221 −2.347 0.01893 0.5542 0.31593 0.27987 0.34152 rs2656822 Imputed T ADD 383 0.5962 0.1685 0.4285 0.8294 −3.07 0.00214 0.05071 0.26762 0.2044 0.3125 rs2656823 Imputed G ADD 383 0.5962 0.1685 0.4285 0.8294 −3.07 0.00214 0.05071 0.26762 0.2044 0.3125 rs2656825 Imputed T ADD 362 0.558 0.1868 0.387 0.8047 −3.123 0.00179 0.4731 0.23895 0.17763 0.28333 rs2764766 Imputed C REC 383 1.776 0.3462 0.901 3.5 1.659 0.09717 0.8147 0.32115 0.32704 0.31696 rs2793101 Imputed T ADD 383 0.6263 0.2568 0.3786 1.036 −1.822 0.06842 0.2863 0.10705 0.08491 0.12277 rs2793101 Imputed T DOM 383 0.5997 0.2668 0.3555 1.012 −1.916 0.05534 0.2863 0.10705 0.08491 0.12277 rs2795871 Imputed A ADD 382 0.3627 0.3488 0.1831 0.7186 −2.908 0.00364 0.2402 0.06806 0.03774 0.08969 rs2795886 Imputed A ADD 383 0.3343 0.376 0.16 0.6986 −2.914 0.00357 0.3826 0.06005 0.03145 0.08036 rs2795886 Imputed A DOM 383 0.3343 0.376 0.16 0.6986 −2.914 0.00357 0.3826 0.06005 0.03145 0.08036 rs2859994 Imputed C GEN 378 6.173 0.04567 0.2908 0.41931 0.47115 0.38288 rs2870464 Imputed G DOM 383 1.373 0.2699 0.8092 2.331 1.176 0.2398 0.7607 0.09399 0.11006 0.08259 rs2875528 Imputed T DOM 383 2.42 0.2725 1.419 4.128 3.244 0.00118 0.3464 0.09138 0.12893 0.06473 rs2876227 Imputed C ADD 380 1.396 0.1502 1.04 1.874 2.221 0.02634 0.1846 0.36579 0.41026 0.33482 rs2876227 Imputed C GEN 380 5.549 0.06238 0.1846 0.36579 0.41026 0.33482 rs2882097 Imputed A DOM 383 1.367 0.2096 0.9065 2.062 1.491 0.1358 0.4613 0.29373 0.31761 0.27679 rs2921983 Imputed C ADD 375 0.5761 0.1731 0.4103 0.8087 −3.187 0.00144 0.04386 0.26 0.19355 0.30682 rs2987537 Imputed C DOM 383 0.5886 0.2614 0.3526 0.9826 −2.027 0.04264 0.8057 0.1188 0.09119 0.13839 rs2996416 Imputed C ADD 382 0.5791 0.2661 0.3437 0.9755 −2.053 0.04007 0.7684 0.09686 0.06962 0.11607 rs2996416 Imputed C DOM 382 0.5573 0.2856 0.3184 0.9754 −2.047 0.04066 0.7684 0.09686 0.06962 0.11607 rs3015527 Imputed C ADD 377 0.5922 0.2667 0.3511 0.9989 −1.964 0.04953 0.7661 0.09682 0.07051 0.11538 rs3015527 Imputed C DOM 377 0.572 0.2869 0.326 1.004 −1.947 0.05151 0.7661 0.09682 0.07051 0.11538 rs3015530 Imputed C ADD 383 0.5758 0.2661 0.3418 0.97 −2.074 0.03805 0.7681 0.09661 0.06918 0.11607 rs3015530 Imputed C DOM 383 0.554 0.2856 0.3166 0.9696 −2.068 0.03864 0.7681 0.09661 0.06918 0.11607 rs3015531 Imputed T ADD 383 0.5758 0.2661 0.3418 0.97 −2.074 0.03805 0.7681 0.09661 0.06918 0.11607 rs3015531 Imputed T DOM 383 0.554 0.2856 0.3166 0.9696 −2.068 0.03864 0.7681 0.09661 0.06918 0.11607 rs3015535 Imputed C ADD 383 0.5758 0.2661 0.3418 0.97 −2.074 0.03805 0.7681 0.09661 0.06918 0.11607 rs3015535 Imputed C DOM 383 0.554 0.2856 0.3166 0.9696 −2.068 0.03864 0.7681 0.09661 0.06918 0.11607 rs3019407 Imputed A GEN 381 5.56 0.06205 0.1023 0.32546 0.30063 0.34305 rs3019407 Imputed A REC 381 0.3598 0.4403 0.1518 0.8529 −2.321 0.02026 0.1023 0.32546 0.30063 0.34305 rs36071725 Genotyped C GEN 383 4.835 0.08914 0.9112 0.35248 0.39623 0.32143 rs373983 Imputed G DOM 380 1.266 0.2223 0.8189 1.957 1.061 0.2888 0.7504 0.41053 0.42038 0.40359 rs3756154 Imputed C DOM 383 0.6667 0.216 0.4366 1.018 −1.877 0.06051 0.7691 0.22324 0.20126 0.23884 rs3793044 Imputed C ADD 383 2.378 0.3248 1.258 4.495 2.668 0.00763 1 0.05744 0.08491 0.03795 rs3793044 Imputed C DOM 383 2.64 0.3358 1.367 5.099 2.891 0.00384 1 0.05744 0.08491 0.03795 rs3793053 Imputed C ADD 380 2.28 0.3065 1.25 4.157 2.689 0.00717 0.1626 0.06184 0.09177 0.04054 rs3793053 Imputed C DOM 380 2.764 0.3341 1.436 5.32 3.042 0.00235 0.1626 0.06184 0.09177 0.04054 rs3796246 Imputed G ADD 383 0.3513 0.2964 0.1965 0.6279 −3.53 0.00042 1 0.09791 0.05346 0.12946 rs3796246 Imputed G DOM 383 0.3489 0.3028 0.1928 0.6316 −3.478 0.00051 1 0.09791 0.05346 0.12946 rs3805996 Imputed G ADD 382 2.395 0.3248 1.267 4.526 2.688 0.00718 1 0.05759 0.08544 0.03795 rs3805996 Imputed G DOM 382 2.659 0.3358 1.377 5.135 2.912 0.00359 1 0.05759 0.08544 0.03795 rs3806003 Imputed A ADD 383 2.378 0.3248 1.258 4.495 2.668 0.00763 1 0.05744 0.08491 0.03795 rs3806003 Imputed A DOM 383 2.64 0.3358 1.367 5.099 2.891 0.00384 1 0.05744 0.08491 0.03795 rs3806004 Imputed T ADD 382 2.473 0.3048 1.361 4.493 2.97 0.00298 0.193 0.06414 0.0981 0.04018 rs3806004 Imputed T DOM 382 3.015 0.3305 1.578 5.763 3.339 0.00084 0.193 0.06414 0.0981 0.04018 rs3806010 Imputed T ADD 382 2.387 0.3056 1.311 4.345 2.847 0.00442 0.1765 0.06283 0.09494 0.04018 rs3806010 Imputed T DOM 382 2.904 0.3322 1.514 5.569 3.209 0.00133 0.1765 0.06283 0.09494 0.04018 rs3806014 Imputed T ADD 382 2.387 0.3056 1.311 4.345 2.847 0.00442 0.1765 0.06283 0.09494 0.04018 rs3806014 Imputed T DOM 382 2.904 0.3322 1.514 5.569 3.209 0.00133 0.1765 0.06283 0.09494 0.04018 rs3806015 Imputed A ADD 382 2.387 0.3056 1.311 4.345 2.847 0.00442 0.1765 0.06283 0.09494 0.04018 rs3806015 Imputed A DOM 382 2.904 0.3322 1.514 5.569 3.209 0.00133 0.1765 0.06283 0.09494 0.04018 rs3806018 Imputed A ADD 382 2.387 0.3056 1.311 4.345 2.847 0.00442 0.1765 0.06283 0.09494 0.04018 rs3806018 Imputed A DOM 382 2.904 0.3322 1.514 5.569 3.209 0.00133 0.1765 0.06283 0.09494 0.04018 rs3806019 Imputed A ADD 382 2.387 0.3056 1.311 4.345 2.847 0.00442 0.1765 0.06283 0.09494 0.04018 rs3806019 Imputed A DOM 382 2.904 0.3322 1.514 5.569 3.209 0.00133 0.1765 0.06283 0.09494 0.04018 rs3806024 Imputed T ADD 382 2.274 0.3063 1.248 4.146 2.682 0.00732 0.1608 0.06152 0.09119 0.04036 rs3806024 Imputed T DOM 382 2.756 0.334 1.432 5.303 3.035 0.0024 0.1608 0.06152 0.09119 0.04036 rs3847825 Imputed G ADD 382 0.7535 0.1544 0.5568 1.02 −1.833 0.06673 0.9143 0.39005 0.35127 0.41741 rs3847825 Imputed G GEN 382 4.284 0.1174 0.9143 0.39005 0.35127 0.41741 rs3852001 Genotyped C GEN 383 4.104 0.1285 0.3319 0.19713 0.21698 0.18304 rs3852001 Genotyped C REC 383 2.797 0.5134 1.023 7.653 2.004 0.04512 0.3319 0.19713 0.21698 0.18304 rs3852002 Imputed G GEN 383 4.104 0.1285 0.3319 0.19713 0.21698 0.18304 rs3852002 Imputed G REC 383 2.797 0.5134 1.023 7.653 2.004 0.04512 0.3319 0.19713 0.21698 0.18304 rs3852003 Imputed A GEN 383 4.104 0.1285 0.3319 0.19713 0.21698 0.18304 rs3852003 Imputed A REC 383 2.797 0.5134 1.023 7.653 2.004 0.04512 0.3319 0.19713 0.21698 0.18304 rs3942254 Imputed T DOM 351 0.5955 0.227 0.3817 0.9293 −2.283 0.02242 0.737 0.38746 0.33916 0.42067 rs3945085 Imputed A DOM 383 1.391 0.2096 0.9222 2.098 1.574 0.1155 0.5365 0.29112 0.31761 0.27232 rs399485 Imputed A DOM 382 1.379 0.2101 0.9136 2.082 1.53 0.126 0.6346 0.31283 0.33648 0.29596 rs4029119 Imputed G ADD 382 0.1157 1.052 0.01473 0.9094 −2.05 0.04034 1 0.01571 0.00316 0.02455 rs4029119 Imputed G DOM 382 0.1157 1.052 0.01473 0.9094 −2.05 0.04034 1 0.01571 0.00316 0.02455 rs412791 Imputed C GEN 367 2.832 0.2427 0.5643 0.34605 0.31731 0.3673 rs4146972 Genotyped T DOM 383 1.672 0.2418 1.041 2.685 2.125 0.03357 0.4985 0.13055 0.16352 0.10714 rs4259369 Imputed C REC 383 0.4161 0.2795 0.2406 0.7196 −3.137 0.00171 0.6078 0.46867 0.39937 0.51786 rs4273613 Imputed T ADD 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs4273613 Imputed T DOM 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs4294022 Imputed C DOM 383 0.5507 0.2147 0.3616 0.8388 −2.779 0.00546 0.3404 0.25065 0.21384 0.27679 rs4310554 Genotyped C DOM 383 1.609 0.2628 0.9616 2.694 1.811 0.07014 0.681 0.53786 0.57547 0.51116 rs4315598 Imputed T ADD 382 1.42 0.1496 1.06 1.904 2.347 0.01894 0.1477 0.35864 0.40566 0.32511 rs4315598 Imputed T GEN 382 6.306 0.04271 0.1477 0.35864 0.40566 0.32511 rs4370878 Imputed G DOM 383 1.391 0.2096 0.9222 2.098 1.574 0.1155 0.5365 0.29112 0.31761 0.27232 rs4436200 Imputed C ADD 383 0.5856 0.2343 0.37 0.9269 −2.284 0.02238 0.6515 0.12794 0.09434 0.15179 rs4444612 Imputed G ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs4444612 Imputed G GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs4450660 Imputed C DOM 383 1.719 0.2141 1.13 2.615 2.53 0.01141 0.6453 0.21149 0.24843 0.18527 rs4463950 Imputed C DOM 379 0.5555 0.2195 0.3613 0.8542 −2.678 0.00741 0.05998 0.43272 0.37342 0.47511 rs4509702 Imputed C DOM 383 1.391 0.2096 0.9222 2.098 1.574 0.1155 0.5365 0.29112 0.31761 0.27232 rs4533379 Imputed G ADD 380 1.429 0.1671 1.03 1.983 2.138 0.03253 0.461 0.29737 0.33544 0.27027 rs4569984 Imputed A DOM 374 0.5254 0.2168 0.3436 0.8036 −2.969 0.00299 0.2184 0.25401 0.21474 0.28211 rs4570530 Imputed C DOM 383 1.391 0.2096 0.9222 2.098 1.574 0.1155 0.5365 0.29112 0.31761 0.27232 rs4571583 Imputed T DOM 383 0.5381 0.2149 0.3531 0.8199 −2.884 0.00392 0.2723 0.24804 0.21069 0.27455 rs4586678 Imputed A DOM 383 1.719 0.2141 1.13 2.615 2.53 0.01141 0.6453 0.21149 0.24843 0.18527 rs4615971 Imputed C DOM 382 1.351 0.2099 0.8952 2.038 1.432 0.152 0.4588 0.29319 0.31646 0.27679 rs4629229 Imputed G DOM 383 0.6821 0.2397 0.4264 1.091 −1.596 0.1105 0.3197 0.15013 0.12579 0.16741 rs4632512 Imputed T GEN 383 4.104 0.1285 0.3319 0.19713 0.21698 0.18304 rs4641552 Imputed A ADD 377 0.5381 0.2751 0.3138 0.9226 −2.253 0.02427 1 0.09682 0.06731 0.11765 rs4682527 Imputed C DOM 364 1.785 0.2238 1.151 2.767 2.588 0.00965 0.08775 0.35852 0.40523 0.32464 rs4688632 Imputed G REC 373 0.656 0.2381 0.4113 1.046 −1.77 0.07666 0.12 0.52145 0.49026 0.54338 rs4702720 Imputed A ADD 320 0.6922 0.2059 0.4623 1.036 −1.787 0.07392 0.7262 0.2 0.16541 0.2246 rs4702720 Imputed A DOM 320 0.7001 0.2406 0.4369 1.122 −1.481 0.1385 0.7262 0.2 0.16541 0.2246 rs4714484 Imputed A ADD 383 0.5988 0.1942 0.4093 0.8761 −2.641 0.00827 0.1255 0.18538 0.13836 0.21875 rs4714484 Imputed A DOM 383 0.5097 0.2319 0.3235 0.803 −2.906 0.00366 0.1255 0.18538 0.13836 0.21875 rs4725142 Genotyped G REC 383 0.3868 0.3771 0.1847 0.81 −2.519 0.01178 0.9099 0.34204 0.3239 0.35491 rs4725144 Imputed G REC 383 0.3868 0.3771 0.1847 0.81 −2.519 0.01178 0.9099 0.34204 0.3239 0.35491 rs4760785 Imputed A ADD 383 0.7632 0.1542 0.5641 1.032 −1.753 0.07966 0.6 0.41775 0.37736 0.44643 rs4760785 Imputed A DOM 383 0.5772 0.2224 0.3733 0.8926 −2.471 0.01349 0.6 0.41775 0.37736 0.44643 rs4760894 Imputed T ADD 383 0.7632 0.1542 0.5641 1.032 −1.753 0.07966 0.6 0.41775 0.37736 0.44643 rs4760894 Imputed T DOM 383 0.5772 0.2224 0.3733 0.8926 −2.471 0.01349 0.6 0.41775 0.37736 0.44643 rs4760895 Imputed A ADD 383 0.7632 0.1542 0.5641 1.032 −1.753 0.07966 0.6 0.41775 0.37736 0.44643 rs4760895 Imputed A DOM 383 0.5772 0.2224 0.3733 0.8926 −2.471 0.01349 0.6 0.41775 0.37736 0.44643 rs4767184 Imputed C ADD 375 0.7432 0.1558 0.5476 1.009 −1.905 0.05677 1 0.392 0.35065 0.42081 rs4767184 Imputed C GEN 375 4.92 0.08545 1 0.392 0.35065 0.42081 rs4773487 Imputed T ADD 380 0.5534 0.2659 0.3287 0.932 −2.225 0.02609 0.7794 0.1 0.07006 0.12108 rs4780547 Imputed G GEN 382 1.722 0.4228 1 0.22644 0.21519 0.23438 rs4780547 Imputed G REC 382 0.5086 0.5339 0.1786 1.448 −1.266 0.2054 1 0.22644 0.21519 0.23438 rs483159 Imputed T DOM 369 1.242 0.2188 0.8087 1.906 0.9893 0.3225 0.7497 0.20461 0.21711 0.19585 rs4836502 Imputed T DOM 383 0.6021 0.2099 0.3991 0.9085 −2.417 0.01564 0.7244 0.31984 0.28302 0.34598 rs4836507 Imputed C DOM 376 0.6042 0.212 0.3988 0.9154 −2.377 0.01745 0.5558 0.32048 0.28387 0.34615 rs4851531 Imputed T DOM 380 0.5595 0.2166 0.366 0.8553 −2.682 0.00733 0.665 0.38553 0.35127 0.40991 rs4879931 Imputed G ADD 382 0.7554 0.1662 0.5453 1.046 −1.688 0.09145 0.2407 0.32199 0.28931 0.34529 rs489441 Imputed G ADD 357 1.491 0.172 1.064 2.089 2.322 0.02024 0.4487 0.29552 0.34354 0.2619 rs489441 Imputed G DOM 357 1.551 0.2175 1.013 2.376 2.018 0.04362 0.4487 0.29552 0.34354 0.2619 rs4976276 Imputed T ADD 382 1.499 0.1578 1.1 2.042 2.566 0.01029 0.6569 0.35995 0.41456 0.32143 rs4977681 Imputed C REC 380 2.078 0.3396 1.068 4.042 2.153 0.03132 0.1768 0.34868 0.37898 0.32735 rs4986197 Imputed G ADD 379 1.42 0.1672 1.023 1.97 2.097 0.03598 0.4609 0.29683 0.33439 0.27027 rs4986220 Imputed T ADD 383 1.437 0.1677 1.034 1.996 2.162 0.03065 0.3893 0.29243 0.33019 0.26563 rs525462 Imputed A GEN 382 9.552 0.00843 0.9148 0.6034 0.54088 0.64798 rs552006 Imputed G GEN 380 6.857 0.03243 0.3034 0.27237 0.31447 0.24208 rs5756669 Imputed C DOM 383 1.639 0.2271 1.05 2.558 2.175 0.02962 0.8346 0.42428 0.44654 0.40848 rs581905 Imputed T DOM 383 1.341 0.2854 0.7666 2.347 1.029 0.3036 0.7263 0.08094 0.09119 0.07366 rs6033138 Imputed C ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs6033138 Imputed C GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs6040619 Imputed C ADD 374 1.432 0.1515 1.064 1.927 2.368 0.01789 0.1811 0.3623 0.41026 0.32798 rs6040619 Imputed C GEN 374 6.205 0.04493 0.1811 0.3623 0.41026 0.32798 rs6040625 Imputed T ADD 380 1.45 0.1506 1.079 1.947 2.466 0.01364 0.1459 0.35658 0.40705 0.32143 rs6040625 Imputed T GEN 380 6.611 0.03669 0.1459 0.35658 0.40705 0.32143 rs6040630 Imputed A ADD 383 1.444 0.1501 1.076 1.938 2.448 0.01435 0.1808 0.3564 0.40566 0.32143 rs6040630 Imputed A GEN 383 6.635 0.03624 0.1808 0.3564 0.40566 0.32143 rs6040633 Imputed A ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs6040633 Imputed A GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs6040634 Imputed T ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs6040634 Imputed T GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs6040636 Imputed T ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs6040636 Imputed T GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs6040638 Imputed C ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs6040638 Imputed C GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs6040644 Imputed A ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs6040644 Imputed A GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs6040667 Imputed T ADD 381 1.419 0.1495 1.058 1.902 2.339 0.01935 0.09512 0.35696 0.40446 0.32366 rs6040667 Imputed T GEN 381 6.102 0.04731 0.09512 0.35696 0.40446 0.32366 rs6040668 Imputed C ADD 381 1.419 0.1495 1.058 1.902 2.339 0.01935 0.09512 0.35696 0.40446 0.32366 rs6040668 Imputed C GEN 381 6.102 0.04731 0.09512 0.35696 0.40446 0.32366 rs6053005 Imputed C DOM 283 0.3707 0.3223 0.1971 0.6972 −3.079 0.00207 0.3237 0.59717 0.52542 0.64848 rs6054405 Imputed A REC 379 1.796 0.3119 0.9747 3.31 1.878 0.0604 0.4419 0.36939 0.38854 0.35586 rs6054427 Genotyped G GEN 383 3.524 0.1717 0.1355 0.39687 0.43082 0.37277 rs6075186 Imputed G DOM 383 0.6821 0.2397 0.4264 1.091 −1.596 0.1105 0.3197 0.15013 0.12579 0.16741 rs608278 Imputed A ADD 345 0.6427 0.1607 0.4691 0.8807 −2.751 0.00594 0.9142 0.48116 0.42414 0.5225 rs6111540 Imputed A ADD 347 0.7778 0.1612 0.5671 1.067 −1.558 0.1191 0.5914 0.48271 0.44178 0.51244 rs6131206 Imputed C ADD 380 1.462 0.1555 1.078 1.983 2.445 0.01449 0.1924 0.31447 0.36306 0.28027 rs6131208 Imputed T ADD 381 1.419 0.1495 1.058 1.902 2.339 0.01935 0.09512 0.35696 0.40446 0.32366 rs6131208 Imputed T GEN 381 6.102 0.04731 0.09512 0.35696 0.40446 0.32366 rs6131919 Imputed G DOM 383 0.6821 0.2397 0.4264 1.091 −1.596 0.1105 0.3197 0.15013 0.12579 0.16741 rs6134243 Imputed C ADD 383 1.429 0.1494 1.066 1.915 2.388 0.01695 0.1203 0.3577 0.40566 0.32366 rs6134243 Imputed C GEN 383 6.537 0.03806 0.1203 0.3577 0.40566 0.32366 rs6136020 Imputed A DOM 383 0.6821 0.2397 0.4264 1.091 −1.596 0.1105 0.3197 0.15013 0.12579 0.16741 rs613799 Imputed C DOM 373 1.426 0.2134 0.9386 2.167 1.663 0.0963 0.4587 0.29759 0.32566 0.27828 rs644041 Imputed G ADD 349 1.523 0.1742 1.082 2.142 2.415 0.01575 0.5224 0.29799 0.35 0.26316 rs644041 Imputed G DOM 349 1.58 0.2213 1.024 2.438 2.067 0.03874 0.5224 0.29799 0.35 0.26316 rs6464377 Imputed C DOM 383 1.743 0.2989 0.9701 3.131 1.859 0.06309 1 0.0718 0.08805 0.06027 rs6474230 Imputed T DOM 383 1.832 0.2138 1.205 2.786 2.832 0.00463 0.4624 0.22454 0.28302 0.18304 rs6476565 Imputed A DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs6511286 Imputed T ADD 382 1.657 0.1628 1.204 2.28 3.103 0.00192 0.9052 0.31021 0.37107 0.26682 rs6541829 Genotyped C REC 383 3.048 0.4236 1.329 6.991 2.631 0.00851 0.7014 0.27415 0.29874 0.2567 rs6544721 Imputed G DOM 383 1.782 0.2114 1.178 2.697 2.733 0.00628 0.7817 0.24413 0.29245 0.20982 rs6544728 Imputed T DOM 377 1.8 0.2171 1.177 2.755 2.709 0.00675 0.7509 0.20424 0.24522 0.175 rs6565910 Imputed G DOM 383 0.6325 0.2139 0.4159 0.9619 −2.141 0.03224 0.3965 0.23629 0.19811 0.26339 rs6581985 Imputed G GEN 383 5.059 0.07972 0.6393 0.32115 0.34277 0.3058 rs6581985 Imputed G REC 383 2.122 0.3548 1.058 4.253 2.12 0.03402 0.6393 0.32115 0.34277 0.3058 rs6685186 Imputed T ADD 383 1.364 0.1533 1.01 1.842 2.026 0.04275 0.9138 0.38251 0.42453 0.35268 rs6685186 Imputed T GEN 383 4.244 0.1198 0.9138 0.38251 0.42453 0.35268 rs670593 Imputed A REC 383 0.6178 0.2944 0.347 1.1 −1.636 0.1018 0.6696 0.39817 0.36478 0.42188 rs6722640 Imputed T DOM 382 0.5778 0.2162 0.3783 0.8827 −2.537 0.01117 0.5916 0.38874 0.35849 0.41031 rs6746170 Imputed A DOM 380 1.811 0.2168 1.184 2.77 2.739 0.00616 0.7506 0.20263 0.24367 0.17342 rs6757316 Imputed A GEN 380 5.94 0.05131 0.535 0.44737 0.49367 0.41441 rs6805139 Imputed G DOM 376 1.64 0.2386 1.028 2.618 2.074 0.03807 0.1787 0.47606 0.51613 0.44796 rs6808571 Imputed G ADD 378 1.439 0.2034 0.9658 2.143 1.789 0.07364 1 0.15741 0.18671 0.13636 rs6816479 Imputed A REC 383 2.214 0.2867 1.262 3.883 2.772 0.00557 0.8315 0.40078 0.45912 0.35938 rs6865976 Imputed C DOM 305 0.5474 0.2612 0.3281 0.9134 −2.307 0.02106 0.646 0.47377 0.42692 0.50857 rs687047 Imputed C ADD 383 0.7104 0.232 0.4509 1.119 −1.474 0.1405 0.8148 0.12272 0.10377 0.13616 rs6871041 Imputed G DOM 367 0.6093 0.2145 0.4002 0.9278 −2.31 0.02092 0.7102 0.29837 0.26144 0.32477 rs688358 Imputed A ADD 382 0.6857 0.2311 0.4359 1.079 −1.632 0.1026 0.4845 0.12304 0.10127 0.13839 rs6908481 Imputed C REC 375 1.848 0.262 1.106 3.088 2.344 0.01908 0.7545 0.45333 0.46452 0.44545 rs6917224 Imputed A ADD 382 1.351 0.1419 1.023 1.784 2.118 0.0342 0.02099 0.42408 0.47152 0.39063 rs6917224 Imputed A GEN 382 6.409 0.04058 0.02099 0.42408 0.47152 0.39063 rs6920677 Imputed G DOM 380 0.5128 0.2196 0.3335 0.7886 −3.041 0.00235 0.5212 0.39868 0.31847 0.45516 rs6994498 Imputed G DOM 383 1.832 0.2138 1.205 2.786 2.832 0.00463 0.4624 0.22454 0.28302 0.18304 rs6998772 Imputed T DOM 383 2.739 0.4524 1.128 6.647 2.227 0.02596 0.00643 0.03394 0.05031 0.02232 rs7022281 Imputed C ADD 382 0.7264 0.1589 0.532 0.9919 −2.011 0.04432 0.1999 0.39791 0.35849 0.42601 rs7022281 Imputed C GEN 382 4.073 0.1305 0.1999 0.39791 0.35849 0.42601 rs7022281 Imputed C REC 382 0.6555 0.3107 0.3565 1.205 −1.359 0.174 0.1999 0.39791 0.35849 0.42601 rs7043983 Imputed T DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs7077799 Imputed A DOM 382 1.355 0.2098 0.8985 2.045 1.45 0.1471 0.4624 0.2945 0.31761 0.27803 rs7088947 Imputed A ADD 383 0.3545 0.3478 0.1793 0.7009 −2.982 0.00287 0.2394 0.06919 0.03774 0.09152 rs7089661 Imputed C DOM 382 1.351 0.2099 0.8952 2.038 1.432 0.152 0.4588 0.29319 0.31646 0.27679 rs7102072 Imputed A DOM 381 0.6088 0.2112 0.4024 0.9209 −2.35 0.01876 0.902 0.29265 0.25316 0.32063 rs710832 Genotyped A REC 383 0.2657 0.5623 0.08825 0.7997 −2.357 0.0184 0.5936 0.25849 0.24214 0.27009 rs712531 Imputed A DOM 371 1.787 0.2215 1.158 2.759 2.622 0.00874 0.0548 0.35445 0.40323 0.31944 rs7129817 Imputed T ADD 383 0.6903 0.1578 0.5066 0.9405 −2.348 0.01886 0.6497 0.34204 0.2956 0.375 rs7134262 Imputed T GEN 383 3.342 0.1881 0.3841 0.37728 0.40252 0.35938 rs7134262 Imputed T REC 383 1.737 0.3064 0.9527 3.167 1.802 0.07156 0.3841 0.37728 0.40252 0.35938 rs7138300 Imputed C ADD 383 0.7632 0.1542 0.5641 1.032 −1.753 0.07966 0.6 0.41775 0.37736 0.44643 rs7138300 Imputed C DOM 383 0.5772 0.2224 0.3733 0.8926 −2.471 0.01349 0.6 0.41775 0.37736 0.44643 rs722927 Imputed G ADD 383 0.4322 0.319 0.2313 0.8077 −2.63 0.00855 0.7112 0.07572 0.04717 0.09598 rs722927 Imputed G DOM 383 0.433 0.3231 0.2299 0.8157 −2.59 0.00958 0.7112 0.07572 0.04717 0.09598 rs726424 Genotyped G ADD 383 0.7473 0.1542 0.5524 1.011 −1.889 0.05889 0.9144 0.38903 0.34906 0.41741 rs726424 Genotyped G GEN 383 4.55 0.1028 0.9144 0.38903 0.34906 0.41741 rs7295817 Imputed C ADD 381 0.7394 0.1533 0.5475 0.9985 −1.97 0.04885 0.9158 0.40551 0.36306 0.43527 rs7295817 Imputed C GEN 381 4.446 0.1083 0.9158 0.40551 0.36306 0.43527 rs7295817 Imputed C REC 381 0.747 0.2896 0.4235 1.318 −1.007 0.3139 0.9158 0.40551 0.36306 0.43527 rs7297372 Imputed A ADD 338 0.7506 0.1757 0.532 1.059 −1.633 0.1025 0.00146 0.53846 0.50368 0.56188 rs7297372 Imputed A GEN 338 2.895 0.2351 0.00146 0.53846 0.50368 0.56188 rs7298255 Imputed A ADD 382 0.7489 0.1551 0.5526 1.015 −1.864 0.06235 0.5292 0.41623 0.37342 0.44643 rs7298255 Imputed A DOM 382 0.571 0.2227 0.3691 0.8835 −2.516 0.01186 0.5292 0.41623 0.37342 0.44643 rs7305832 Imputed C GEN 383 3.342 0.1881 0.3841 0.37728 0.40252 0.35938 rs7305832 Imputed C REC 383 1.737 0.3064 0.9527 3.167 1.802 0.07156 0.3841 0.37728 0.40252 0.35938 rs737542 Imputed A REC 381 3.431 0.4396 1.45 8.122 2.804 0.00504 0.6064 0.27297 0.30063 0.25336 rs742827 Imputed A ADD 361 1.416 0.1525 1.05 1.91 2.282 0.02249 0.1122 0.36704 0.41391 0.33333 rs742827 Imputed A GEN 361 5.995 0.0499 0.1122 0.36704 0.41391 0.33333 rs7446891 Imputed G DOM 373 0.5964 0.2125 0.3932 0.9046 −2.432 0.01503 0.6302 0.31099 0.27419 0.33716 rs7448641 Imputed C ADD 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs7448641 Imputed C DOM 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs7460605 Imputed G DOM 361 1.533 0.2243 0.988 2.38 1.906 0.05662 0.2254 0.39474 0.42105 0.3756 rs7468898 Imputed T ADD 379 1.539 0.1544 1.137 2.083 2.791 0.00526 0.7518 0.42084 0.48089 0.37838 rs7468898 Imputed T GEN 379 7.907 0.01919 0.7518 0.42084 0.48089 0.37838 rs7501186 Imputed A DOM 383 1.277 0.2476 0.7859 2.074 0.9866 0.3238 0.8082 0.1201 0.13836 0.10714 rs755117 Imputed A DOM 375 1.758 0.223 1.135 2.722 2.53 0.01142 0.8628 0.18267 0.22436 0.15297 rs7557560 Imputed T GEN 383 10.8 0.00451 0.08079 0.20104 0.24528 0.16964 rs7557560 Imputed T REC 383 6.446 0.567 2.122 19.58 3.286 0.00102 0.08079 0.20104 0.24528 0.16964 rs7562462 Imputed T DOM 380 1.588 0.2435 0.9851 2.559 1.898 0.05765 0.2578 0.46974 0.50316 0.44595 rs757173 Genotyped G DOM 383 0.683 0.2133 0.4496 1.038 −1.787 0.0739 0.8284 0.3812 0.34906 0.40402 rs7607447 Imputed T REC 332 1.964 0.3733 0.9451 4.083 1.809 0.0705 0.8998 0.31928 0.34173 0.30311 rs7639053 Imputed A ADD 383 1.6 0.1803 1.124 2.278 2.608 0.00912 0.3899 0.22977 0.27673 0.19643 rs7648163 Imputed C REC 358 2.989 0.3458 1.518 5.886 3.166 0.00154 0.816 0.34916 0.39333 0.31731 rs7651273 Imputed A GEN 383 3.158 0.2061 0.4152 0.19452 0.21384 0.1808 rs7653190 Imputed C ADD 382 1.616 0.1806 1.134 2.302 2.658 0.00786 0.3892 0.23037 0.27848 0.19643 rs7653685 Genotyped C DOM 383 2.42 0.2725 1.419 4.128 3.244 0.00118 0.758 0.09269 0.12893 0.06696 rs7684899 Imputed C DOM 383 0.6667 0.216 0.4366 1.018 −1.877 0.06051 0.7691 0.22324 0.20126 0.23884 rs7701604 Imputed G ADD 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs7701604 Imputed G DOM 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs7703676 Imputed C ADD 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs7703676 Imputed C DOM 383 0.235 0.778 0.05116 1.08 −1.861 0.0627 1 0.01697 0.00629 0.02455 rs7711358 Imputed A DOM 383 0.6113 0.2097 0.4053 0.9221 −2.347 0.01893 0.4104 0.31723 0.28302 0.34152 rs7713251 Imputed C REC 367 2.559 0.3384 1.319 4.968 2.777 0.00548 0.7295 0.34605 0.38816 0.31628 rs7737608 Imputed G DOM 382 1.5 0.2234 0.9683 2.324 1.816 0.06938 0.6005 0.41754 0.4462 0.39732 rs7755903 Imputed A GEN 382 9.733 0.0077 1 0.42539 0.36478 0.46861 rs7762993 Imputed A ADD 378 1.373 0.1976 0.9323 2.023 1.605 0.1084 0.2987 0.18122 0.20701 0.1629 rs7762993 Imputed A DOM 378 1.537 0.2206 0.9974 2.368 1.948 0.0514 0.2987 0.18122 0.20701 0.1629 rs7767265 Imputed G DOM 382 1.53 0.2141 1.005 2.327 1.985 0.04716 0.453 0.21859 0.24843 0.19731 rs7769415 Imputed C GEN 376 3.721 0.1556 0.9073 0.32846 0.34295 0.31818 rs7771264 Imputed T DOM 383 0.5507 0.2147 0.3616 0.8388 −2.779 0.00546 0.3404 0.25065 0.21384 0.27679 rs7795792 Imputed T REC 383 0.4161 0.2795 0.2406 0.7196 −3.137 0.00171 0.6078 0.46867 0.39937 0.51786 rs7806481 Imputed G REC 383 0.628 0.2629 0.3751 1.051 −1.77 0.0768 0.47 0.4517 0.43082 0.46652 rs7808536 Imputed G DOM 383 1.952 0.2193 1.27 3 3.05 0.00229 1 0.19191 0.23899 0.15848 rs7814819 Imputed G ADD 225 1.743 0.3691 0.8454 3.593 1.505 0.1324 1 0.07333 0.09551 0.05882 rs7814819 Imputed G DOM 225 1.939 0.386 0.9098 4.131 1.715 0.08632 1 0.07333 0.09551 0.05882 rs7815952 Imputed T DOM 383 2.739 0.4524 1.128 6.647 2.227 0.02596 0.00643 0.03394 0.05031 0.02232 rs7834090 Imputed T DOM 383 2.739 0.4524 1.128 6.647 2.227 0.02596 0.00643 0.03394 0.05031 0.02232 rs7859250 Imputed C DOM 383 0.4711 0.3006 0.2614 0.8493 −2.503 0.0123 0.2271 0.09138 0.06289 0.11161 rs7863577 Genotyped A ADD 383 0.5916 0.2865 0.3374 1.037 −1.832 0.06689 0.7318 0.08225 0.05975 0.09821 rs7863577 Genotyped A DOM 383 0.5571 0.3041 0.307 1.011 −1.924 0.0544 0.7318 0.08225 0.05975 0.09821 rs7902140 Imputed C ADD 378 0.622 0.2115 0.4109 0.9414 −2.245 0.02475 0.5866 0.16931 0.13226 0.19507 rs7921834 Imputed C DOM 382 1.351 0.2099 0.8952 2.038 1.432 0.152 0.4588 0.29319 0.31646 0.27679 rs7939893 Imputed C ADD 382 0.8314 0.1592 0.6085 1.136 −1.16 0.2462 0.4351 0.3534 0.33333 0.36771 rs7939893 Imputed C DOM 382 0.6782 0.2127 0.447 1.029 −1.826 0.0679 0.4351 0.3534 0.33333 0.36771 rs7955901 Imputed C ADD 383 0.7632 0.1542 0.5641 1.032 −1.753 0.07966 0.6 0.41775 0.37736 0.44643 rs7955901 Imputed C DOM 383 0.5772 0.2224 0.3733 0.8926 −2.471 0.01349 0.6 0.41775 0.37736 0.44643 rs7956274 Imputed T ADD 382 0.7489 0.1551 0.5526 1.015 −1.864 0.06235 0.5292 0.41623 0.37342 0.44643 rs7956274 Imputed T DOM 382 0.571 0.2227 0.3691 0.8835 −2.516 0.01186 0.5292 0.41623 0.37342 0.44643 rs7957932 Imputed G ADD 380 0.7622 0.1541 0.5635 1.031 −1.762 0.07806 0.6008 0.42895 0.38854 0.4574 rs7957932 Imputed G DOM 380 0.5724 0.2251 0.3682 0.8898 −2.479 0.01319 0.6008 0.42895 0.38854 0.4574 rs7984294 Imputed A DOM 341 1.992 0.4122 0.888 4.468 1.672 0.09458 1 0.03959 0.05594 0.02778 rs7994286 Imputed A ADD 377 0.5714 0.2665 0.3389 0.9633 −2.1 0.03571 0.7705 0.09814 0.07006 0.11818 rs7994286 Imputed A DOM 377 0.5491 0.2859 0.3135 0.9616 −2.097 0.03601 0.7705 0.09814 0.07006 0.11818 rs8038229 Genotyped A ADD 383 0.6055 0.165 0.4381 0.8367 −3.04 0.00237 0.3986 0.30418 0.24528 0.34598 rs8038229 Genotyped A DOM 383 0.534 0.2122 0.3523 0.8093 −2.957 0.0031 0.3986 0.30418 0.24528 0.34598 rs8043336 Imputed C GEN 370 8.202 0.01656 0.3028 0.34865 0.2987 0.38426 rs8043336 Imputed C REC 370 0.3477 0.3977 0.1595 0.758 −2.657 0.00789 0.3028 0.34865 0.2987 0.38426 rs8054431 Imputed T DOM 372 2.022 0.2234 1.305 3.133 3.153 0.00162 0.3127 0.3629 0.42308 0.31944 rs8066502 Imputed T DOM 383 0.6823 0.229 0.4356 1.069 −1.669 0.09506 0.8575 0.17232 0.15094 0.1875 rs8068714 Imputed T DOM 383 0.7037 0.2279 0.4502 1.1 −1.542 0.1231 0.8589 0.17363 0.15409 0.1875 rs892575 Imputed T ADD 383 1.417 0.1666 1.022 1.964 2.092 0.03642 0.4618 0.29634 0.33333 0.27009 rs892583 Imputed G ADD 383 1.437 0.1677 1.034 1.996 2.162 0.03065 0.3893 0.29243 0.33019 0.26563 rs915494 Imputed A ADD 374 1.204 0.1605 0.8791 1.649 1.157 0.2474 0.3776 0.28877 0.31046 0.27376 rs915494 Imputed A DOM 374 1.279 0.2121 0.8439 1.938 1.16 0.2462 0.3776 0.28877 0.31046 0.27376 rs917295 Imputed G DOM 383 0.6021 0.2099 0.3991 0.9085 −2.417 0.01564 0.7244 0.31984 0.28302 0.34598 rs922594 Imputed T DOM 375 0.5825 0.2147 0.3824 0.8872 −2.518 0.01181 0.4237 0.34133 0.3 0.37045 rs9301653 Imputed T ADD 383 0.5758 0.2661 0.3418 0.97 −2.074 0.03805 0.7681 0.09661 0.06918 0.11607 rs9301653 Imputed T DOM 383 0.554 0.2856 0.3166 0.9696 −2.068 0.03864 0.7681 0.09661 0.06918 0.11607 rs9309988 Imputed G DOM 383 2.42 0.2725 1.419 4.128 3.244 0.00118 0.758 0.09269 0.12893 0.06696 rs9309989 Genotyped C DOM 383 2.42 0.2725 1.419 4.128 3.244 0.00118 0.758 0.09269 0.12893 0.06696 rs9310221 Imputed A DOM 352 1.531 0.2314 0.9727 2.41 1.84 0.06574 0.7387 0.39915 0.40972 0.39183 rs9327555 Imputed T DOM 383 0.6021 0.2099 0.3991 0.9085 −2.417 0.01564 0.7244 0.31984 0.28302 0.34598 rs937890 Imputed G DOM 383 0.7037 0.2279 0.4502 1.1 −1.542 0.1231 0.8589 0.17363 0.15409 0.1875 rs9454967 Imputed G ADD 382 2.387 0.3056 1.311 4.345 2.847 0.00442 0.1765 0.06283 0.09494 0.04018 rs9454967 Imputed G DOM 382 2.904 0.3322 1.514 5.569 3.209 0.00133 0.1765 0.06283 0.09494 0.04018 rs9471295 Imputed T DOM 383 1.488 0.2326 0.9435 2.348 1.71 0.08731 0.5442 0.14883 0.16667 0.13616 rs9477007 Imputed A ADD 380 1.357 0.1432 1.025 1.797 2.132 0.03298 0.04681 0.42763 0.47484 0.39367 rs9477007 Imputed A GEN 380 5.531 0.06295 0.04681 0.42763 0.47484 0.39367 rs9487279 Imputed T DOM 366 0.5667 0.2254 0.3643 0.8814 −2.52 0.01173 0.1024 0.40164 0.33882 0.44626 rs949016 Imputed C ADD 383 1.437 0.1677 1.034 1.996 2.162 0.03065 0.3893 0.29243 0.33019 0.26563 rs9555973 Imputed G ADD 379 0.5702 0.2704 0.3356 0.9686 −2.078 0.03773 0.7618 0.09499 0.06731 0.11435 rs9555973 Imputed G DOM 379 0.5463 0.2905 0.3091 0.9655 −2.081 0.03744 0.7618 0.09499 0.06731 0.11435 rs9557510 Imputed G ADD 383 1.582 0.1986 1.072 2.334 2.308 0.02098 0.2295 0.15144 0.18868 0.125 rs9557510 Imputed G DOM 383 1.775 0.2327 1.125 2.801 2.466 0.01365 0.2295 0.15144 0.18868 0.125 rs9560584 Imputed T DOM 382 0.5572 0.2856 0.3184 0.9752 −2.048 0.04058 0.7684 0.09686 0.06962 0.11607 rs9588770 Imputed T DOM 381 0.497 0.2943 0.2792 0.8849 −2.376 0.01752 0.7612 0.09449 0.06329 0.11659 rs9588848 Imputed C ADD 383 0.5758 0.2661 0.3418 0.97 −2.074 0.03805 0.7681 0.09661 0.06918 0.11607 rs9588848 Imputed C DOM 383 0.554 0.2856 0.3166 0.9696 −2.068 0.03864 0.7681 0.09661 0.06918 0.11607 rs966583 Imputed A ADD 382 0.7239 0.1599 0.5291 0.9903 −2.021 0.04332 0.1993 0.39398 0.34906 0.42601 rs966583 Imputed A DOM 382 0.6175 0.2202 0.4011 0.9507 −2.189 0.02856 0.1993 0.39398 0.34906 0.42601 rs974130 Genotyped A REC 383 2.214 0.2867 1.262 3.883 2.772 0.00557 0.8315 0.40078 0.45912 0.35938 rs977160 Imputed T ADD 382 1.378 0.1666 0.9945 1.911 1.927 0.05403 0.7069 0.28403 0.31761 0.26009 rs9812206 Imputed G ADD 383 0.3883 0.2849 0.2221 0.6787 −3.321 0.0009 0.7825 0.10183 0.05975 0.1317 rs9812206 Imputed G DOM 383 0.3876 0.2917 0.2188 0.6867 −3.248 0.00116 0.7825 0.10183 0.05975 0.1317 rs9813552 Imputed G ADD 379 0.3826 0.2913 0.2162 0.6772 −3.298 0.00097 1 0.09894 0.05732 0.12838 rs9813552 Imputed G DOM 379 0.3816 0.2983 0.2127 0.6847 −3.23 0.00124 1 0.09894 0.05732 0.12838 rs9815037 Imputed T ADD 382 0.3819 0.2906 0.2161 0.675 −3.313 0.00092 1 0.09817 0.0566 0.1278 rs9815037 Imputed T DOM 382 0.3809 0.2976 0.2125 0.6825 −3.243 0.00118 1 0.09817 0.0566 0.1278 rs9825349 Imputed A ADD 382 0.3819 0.2906 0.2161 0.675 −3.313 0.00092 1 0.09817 0.0566 0.1278 rs9825349 Imputed A DOM 382 0.3809 0.2976 0.2125 0.6825 −3.243 0.00118 1 0.09817 0.0566 0.1278 rs9834217 Imputed T ADD 382 0.3819 0.2906 0.2161 0.675 −3.313 0.00092 1 0.09817 0.0566 0.1278 rs9834217 Imputed T DOM 382 0.3809 0.2976 0.2125 0.6825 −3.243 0.00118 1 0.09817 0.0566 0.1278 rs9840460 Imputed T ADD 382 0.3819 0.2906 0.2161 0.675 −3.313 0.00092 1 0.09817 0.0566 0.1278 rs9840460 Imputed T DOM 382 0.3809 0.2976 0.2125 0.6825 −3.243 0.00118 1 0.09817 0.0566 0.1278 rs9840756 Imputed A ADD 380 0.3808 0.291 0.2153 0.6737 −3.317 0.00091 1 0.09868 0.05696 0.12838 rs9840756 Imputed A DOM 380 0.3798 0.298 0.2118 0.681 −3.249 0.00116 1 0.09868 0.05696 0.12838 rs9844801 Imputed C DOM 383 2.42 0.2725 1.419 4.128 3.244 0.00118 0.3464 0.09138 0.12893 0.06473 rs985375 Imputed A GEN 374 5.977 0.05036 0.5979 0.26471 0.30844 0.23409 rs9869187 Imputed C ADD 383 0.4258 0.2859 0.2431 0.7458 −2.986 0.00283 1 0.09661 0.05975 0.12277 rs9869187 Imputed C DOM 383 0.4271 0.294 0.24 0.7599 −2.894 0.0038 1 0.09661 0.05975 0.12277 rs9872327 Imputed T DOM 383 2.42 0.2725 1.419 4.128 3.244 0.00118 0.3464 0.09138 0.12893 0.06473 rs9881685 Imputed A ADD 379 0.377 0.2935 0.2121 0.6701 −3.324 0.00089 0.5599 0.09894 0.05769 0.1278 rs9881685 Imputed A DOM 379 0.3761 0.298 0.2098 0.6745 −3.282 0.00103 0.5599 0.09894 0.05769 0.1278 rs9909499 Imputed C DOM 362 1.559 0.2159 1.021 2.381 2.058 0.03962 0.08453 0.2721 0.29801 0.25355 rs9911847 Imputed G DOM 382 0.6877 0.2291 0.4389 1.078 −1.634 0.1023 0.8576 0.17277 0.1519 0.1875 rs9946886 Imputed G REC 156 0.3262 0.5121 0.1196 0.8902 −2.187 0.02873 0.3882 0.36218 0.29452 0.42169 rs9958823 Imputed A ADD 377 1.444 0.1687 1.038 2.01 2.179 0.02933 0.3868 0.29576 0.33439 0.26818 rs9965248 Imputed T ADD 379 1.399 0.167 1.009 1.941 2.011 0.04433 0.537 0.29551 0.33121 0.27027 ALLELE PLACEBO_(—) PLACEBO_(—) PLACEBO_(—) SNP rs # SOURCE (A1) MODEL NMISS PRAVA_A1_HZ_COUNT PRAVA_HET_COUNT PRAVA_A2_HZ_COUNT A1_HZ_COUNT HET_COUNT A2_HZ_COUNT rs198460 Genotyped G REC 383 50 69 40 41 122 61 rs603940 Genotyped G REC 383 19 77 63 43 103 78 rs10021016 Genotyped G GEN 383 14 64 81 11 79 134 rs1003148 Imputed C ADD 383 22 71 66 40 115 69 rs1003148 Imputed C GEN 383 22 71 66 40 115 69 rs1003148 Imputed C REC 383 22 71 66 40 115 69 rs10046799 Imputed C ADD 381 44 82 32 92 104 27 rs10046799 Imputed C GEN 381 44 82 32 92 104 27 rs10051148 Imputed C DOM 383 16 55 88 23 105 96 rs10054055 Imputed T DOM 383 17 55 87 24 105 95 rs10067895 Imputed A DOM 379 17 55 84 24 107 92 rs1008705 Imputed C DOM 276 13 60 44 14 71 74 rs10105871 Imputed C DOM 355 23 73 52 32 86 89 rs10116807 Imputed A GEN 376 10 52 94 5 71 144 rs10116807 Imputed A REC 376 10 52 94 5 71 144 rs10121941 Imputed C DOM 383 2 16 141 3 44 177 rs10128638 Genotyped G DOM 383 39 72 48 64 111 49 rs1012924 Imputed G ADD 383 1 20 138 3 46 175 rs1012924 Imputed G DOM 383 1 20 138 3 46 175 rs1016030 Genotyped G ADD 382 29 89 40 24 118 82 rs1016030 Genotyped G GEN 382 29 89 40 24 118 82 rs1017558 Imputed A REC 382 35 76 48 25 110 88 rs10183431 Imputed T DOM 383 6 67 86 9 65 150 rs10195401 Imputed C DOM 377 14 95 48 22 101 97 rs10239416 Imputed A DOM 381 16 61 82 33 105 84 rs1032188 Imputed G GEN 381 6 62 91 28 84 110 rs1032188 Imputed G REC 381 6 62 91 28 84 110 rs10468988 Imputed G ADD 380 17 71 70 12 94 116 rs10478919 Imputed G DOM 383 18 54 87 24 105 95 rs10506623 Imputed C DOM 383 18 74 67 33 123 68 rs10506626 Imputed A DOM 371 18 72 62 33 125 61 rs10509477 Imputed T DOM 383 16 69 74 20 84 120 rs10511071 Imputed C DOM 383 0 41 118 1 27 196 rs10511072 Imputed G DOM 383 0 41 118 1 27 196 rs10511199 Imputed C ADD 379 10 65 82 6 74 142 rs10513283 Imputed G GEN 383 11 46 102 6 69 149 rs10520072 Imputed T DOM 383 17 56 86 24 107 93 rs1065639 Imputed C DOM 364 19 86 48 20 97 94 rs10733846 Imputed G ADD 381 3 41 113 6 80 138 rs10733846 Imputed G DOM 381 3 41 113 6 80 138 rs10737390 Imputed T DOM 367 22 69 65 33 110 68 rs10749293 Imputed G DOM 382 16 69 74 19 84 120 rs10752159 Imputed G DOM 382 5 64 90 8 57 158 rs10753760 Imputed T ADD 374 31 72 51 27 96 97 rs10753760 Imputed T GEN 374 31 72 51 27 96 97 rs10757887 Imputed C DOM 383 9 44 106 18 86 120 rs10758326 Imputed A ADD 382 19 77 63 36 118 69 rs10758326 Imputed A GEN 382 19 77 63 36 118 69 rs10758326 Imputed A REC 382 19 77 63 36 118 69 rs10762236 Genotyped G ADD 383 3 42 114 6 80 138 rs10765769 Imputed C ADD 378 31 89 37 26 120 75 rs10765769 Imputed C GEN 378 31 89 37 26 120 75 rs10784891 Imputed C ADD 372 22 68 65 32 123 62 rs10784891 Imputed C DOM 372 22 68 65 32 123 62 rs10787923 Imputed G DOM 383 16 69 74 19 84 121 rs10787949 Imputed A DOM 382 17 68 74 19 86 118 rs10787951 Imputed G DOM 382 17 68 74 19 86 118 rs10787983 Imputed C DOM 382 16 68 74 20 84 120 rs10788380 Imputed C ADD 377 51 79 27 60 103 57 rs10788380 Imputed C DOM 377 51 79 27 60 103 57 rs10788380 Imputed C GEN 377 51 79 27 60 103 57 rs10814418 Imputed G DOM 383 2 16 141 3 44 177 rs10831417 Imputed A ADD 383 30 89 40 23 118 83 rs10831417 Imputed A GEN 383 30 89 40 23 118 83 rs10831422 Imputed C ADD 378 29 86 43 22 116 82 rs10831422 Imputed C GEN 378 29 86 43 22 116 82 rs10862931 Imputed C GEN 377 15 65 75 34 99 89 rs10865197 Imputed C DOM 383 6 67 86 9 65 150 rs10871302 Imputed A DOM 382 4 36 119 2 44 177 rs10877463 Imputed C DOM 381 15 65 78 25 114 84 rs10877468 Imputed C DOM 375 15 63 77 25 113 82 rs10879240 Imputed C ADD 383 26 68 65 38 124 62 rs10879242 Imputed A DOM 383 19 74 66 34 122 68 rs10879245 Imputed G DOM 383 19 74 66 34 122 68 rs10879249 Imputed T DOM 383 18 74 67 33 122 69 rs10886452 Imputed A DOM 382 17 68 74 19 86 118 rs10886463 Imputed C DOM 381 17 68 74 20 84 118 rs10886465 Imputed A DOM 383 17 68 74 20 85 119 rs10886526 Imputed C DOM 381 16 68 74 20 83 120 rs10902437 Imputed G ADD 355 20 91 37 35 97 75 rs10941126 Imputed G ADD 383 0 2 157 0 11 213 rs10941126 Imputed G DOM 383 0 2 157 0 11 213 rs10947871 Imputed A DOM 383 2 49 108 8 45 171 rs10972978 Imputed G DOM 383 2 16 141 3 44 177 rs10973012 Imputed A DOM 383 2 16 141 3 44 177 rs10974028 Genotyped G ADD 383 4 31 124 7 67 150 rs10974028 Genotyped G DOM 383 4 31 124 7 67 150 rs11021302 Imputed A ADD 378 29 86 43 22 116 82 rs11021302 Imputed A GEN 378 29 86 43 22 116 82 rs11099644 Imputed G REC 382 35 76 48 25 110 88 rs11138315 Imputed G ADD 364 0 23 129 6 44 162 rs11149802 Imputed T DOM 382 4 36 119 2 44 177 rs1116596 Imputed T DOM 383 18 54 87 24 105 95 rs11178531 Imputed A ADD 381 27 69 61 40 124 60 rs11178531 Imputed A DOM 381 27 69 61 40 124 60 rs11178575 Imputed C GEN 382 27 73 59 25 111 87 rs11178575 Imputed C REC 382 27 73 59 25 111 87 rs11178577 Imputed T GEN 383 27 73 59 25 112 87 rs11178577 Imputed T REC 383 27 73 59 25 112 87 rs11178583 Imputed A DOM 383 18 74 67 33 122 69 rs11178589 Imputed T DOM 382 18 74 67 33 121 69 rs11178594 Imputed C DOM 383 18 74 67 33 123 68 rs11178602 Imputed T DOM 383 18 74 67 33 122 69 rs11178648 Imputed T DOM 382 18 71 69 33 122 69 rs11198877 Imputed T DOM 382 17 68 74 19 86 118 rs11198942 Imputed T DOM 383 16 69 74 20 84 120 rs11221075 Imputed A ADD 378 2 29 126 4 53 164 rs11242020 Imputed T DOM 382 18 53 87 24 105 95 rs11242021 Imputed T DOM 381 17 56 85 24 107 92 rs11242022 Imputed T DOM 380 16 57 86 21 107 93 rs11242023 Imputed T DOM 379 17 56 85 23 106 92 rs1149350 Imputed A DOM 382 8 55 96 10 45 168 rs1150143 Imputed G DOM 379 24 72 61 23 81 118 rs11576627 Imputed T ADD 383 6 43 110 5 46 173 rs11576627 Imputed T DOM 383 6 43 110 5 46 173 rs11602189 Imputed A DOM 374 12 59 82 26 103 92 rs11605163 Imputed A DOM 376 0 27 129 0 20 200 rs11615214 Imputed G ADD 382 21 69 68 37 112 75 rs11615214 Imputed G GEN 382 21 69 68 37 112 75 rs11642394 Imputed C DOM 383 4 36 119 2 44 178 rs11644943 Imputed A ADD 380 9 73 77 11 68 142 rs11656608 Imputed T DOM 383 6 37 116 6 72 146 rs11661309 Imputed A ADD 383 4 34 121 12 68 144 rs11661309 Imputed A DOM 383 4 34 121 12 68 144 rs11666131 Imputed A ADD 382 11 61 86 10 61 153 rs11743355 Imputed C ADD 379 0 2 157 0 11 209 rs11743355 Imputed C DOM 379 0 2 157 0 11 209 rs11746806 Imputed T ADD 383 0 2 157 0 11 213 rs11746806 Imputed T DOM 383 0 2 157 0 11 213 rs11746959 Imputed T ADD 383 0 2 157 0 11 213 rs11746959 Imputed T DOM 383 0 2 157 0 11 213 rs11749272 Imputed T DOM 383 18 54 87 24 105 95 rs11901899 Imputed A DOM 378 18 68 70 16 73 133 rs11926319 Imputed G ADD 380 0 17 140 3 52 168 rs11926319 Imputed G DOM 380 0 17 140 3 52 168 rs11956952 Imputed C DOM 378 17 46 94 15 94 112 rs12025826 Imputed G DOM 377 24 77 56 39 87 94 rs1204522 Imputed C GEN 378 14 75 69 33 105 82 rs1204524 Imputed A GEN 378 14 75 68 33 106 82 rs12153185 Imputed T DOM 379 17 55 84 24 107 92 rs12182651 Imputed T ADD 382 1 28 129 2 14 208 rs12182651 Imputed T DOM 382 1 28 129 2 14 208 rs12193568 Imputed G DOM 237 1 34 62 1 27 112 rs12264914 Imputed C DOM 204 5 32 43 11 55 58 rs12307767 Imputed C DOM 352 13 55 77 20 105 82 rs1232298 Imputed G REC 372 29 59 67 16 94 107 rs12407412 Imputed C ADD 383 6 43 110 5 46 173 rs12407412 Imputed C DOM 383 6 43 110 5 46 173 rs12420184 Imputed G DOM 382 2 34 123 12 61 150 rs12422750 Imputed A DOM 383 13 65 81 22 115 87 rs12446951 Imputed A ADD 266 3 18 84 0 12 149 rs12446951 Imputed A DOM 266 3 18 84 0 12 149 rs12457400 Imputed G DOM 383 1 25 133 2 49 173 rs1247340 Imputed C DOM 383 8 55 96 9 46 169 rs1247341 Imputed C DOM 382 8 55 96 9 45 169 rs12521291 Imputed G ADD 380 19 60 78 32 111 80 rs12526849 Imputed T ADD 380 42 67 50 37 100 84 rs12526849 Imputed T GEN 380 42 67 50 37 100 84 rs12543110 Imputed G DOM 383 14 62 83 8 66 150 rs12678600 Imputed A DOM 381 14 63 82 27 108 87 rs12719415 Imputed T DOM 383 17 56 86 24 107 93 rs12831292 Imputed G DOM 382 18 74 67 33 121 69 rs12923993 Imputed C DOM 383 4 36 119 2 44 178 rs12936964 Imputed T DOM 380 19 91 48 33 98 91 rs12960663 Imputed G ADD 383 4 34 121 12 68 144 rs13038146 Imputed C ADD 383 27 75 57 29 87 108 rs13038146 Imputed C GEN 383 27 75 57 29 87 108 rs13134222 Imputed A GEN 382 5 49 105 20 77 126 rs13172910 Imputed A DOM 379 17 46 94 15 95 112 rs13194907 Imputed A ADD 383 0 27 132 1 15 208 rs13194907 Imputed A DOM 383 0 27 132 1 15 208 rs13195745 Imputed A ADD 383 0 27 132 1 15 208 rs13195745 Imputed A DOM 383 0 27 132 1 15 208 rs1321432 Imputed A REC 383 26 73 60 22 116 86 rs1321457 Imputed G REC 383 26 71 62 23 112 89 rs13265054 Imputed T DOM 381 14 63 82 27 108 87 rs13282131 Imputed C GEN 383 44 77 38 47 105 72 rs13353526 Imputed C DOM 383 0 42 117 1 29 194 rs1336382 Imputed T DOM 383 16 69 74 20 84 120 rs1336383 Imputed T DOM 383 16 69 74 20 84 120 rs1336407 Imputed T DOM 383 16 69 74 20 84 120 rs1336409 Imputed T DOM 382 16 69 74 20 84 119 rs1336596 Imputed A DOM 380 18 67 73 25 118 79 rs1343560 Imputed T ADD 383 1 20 138 3 46 175 rs1343560 Imputed T DOM 383 1 20 138 3 46 175 rs1361987 Imputed T GEN 383 14 75 70 31 109 84 rs1386153 Imputed T ADD 379 12 60 85 27 102 93 rs1386153 Imputed T DOM 379 12 60 85 27 102 93 rs1394015 Imputed C DOM 356 27 83 34 27 107 78 rs1407038 Imputed A REC 382 26 70 62 23 112 89 rs1407039 Imputed A REC 379 26 70 61 23 113 86 rs1412802 Imputed T GEN 381 8 58 93 24 87 111 rs1414865 Imputed T DOM 382 17 68 74 19 86 118 rs1414873 Imputed A DOM 383 16 69 74 20 84 120 rs1414876 Imputed C DOM 383 16 69 74 20 84 120 rs1418671 Imputed C REC 377 39 66 53 30 122 67 rs1419490 Genotyped T GEN 383 14 75 70 31 108 85 rs1434507 Imputed A ADD 381 17 71 71 13 93 116 rs1434508 Imputed T ADD 382 17 71 71 13 94 116 rs1435205 Imputed A ADD 379 10 65 82 6 74 142 rs1443928 Imputed C REC 380 31 76 51 73 108 41 rs1452235 Imputed G GEN 383 16 67 76 36 99 89 rs1452236 Imputed G GEN 383 16 67 76 36 99 89 rs1452237 Imputed G GEN 383 16 67 76 36 99 89 rs1452243 Genotyped T GEN 383 16 67 76 36 99 89 rs1463768 Genotyped G REC 383 36 59 64 22 118 84 rs1463769 Imputed G REC 383 36 59 64 22 118 84 rs1472435 Imputed A ADD 374 0 13 144 0 42 175 rs1472435 Imputed A DOM 374 0 13 144 0 42 175 rs1476714 Imputed A DOM 381 17 55 86 24 106 93 rs1495159 Imputed G ADD 377 11 46 98 27 85 110 rs1495159 Imputed G GEN 377 11 46 98 27 85 110 rs1495375 Imputed A DOM 383 19 74 66 34 122 68 rs1495376 Imputed T DOM 371 35 63 56 48 126 43 rs1495377 Imputed G DOM 370 35 63 56 48 125 43 rs1495381 Imputed T GEN 383 40 68 51 34 117 73 rs1495381 Imputed T REC 383 40 68 51 34 117 73 rs1498992 Imputed G DOM 383 14 59 86 16 106 102 rs1499001 Imputed T DOM 378 11 55 93 11 99 109 rs1512988 Imputed A DOM 380 18 73 67 33 122 67 rs1512989 Imputed T DOM 380 18 73 67 33 122 67 rs1512991 Imputed T ADD 382 25 68 65 38 124 62 rs1512991 Imputed T DOM 382 25 68 65 38 124 62 rs1516855 Imputed G REC 382 27 69 63 17 117 89 rs1527450 Imputed T ADD 383 30 89 40 23 118 83 rs1527450 Imputed T GEN 383 30 89 40 23 118 83 rs1567740 Imputed T DOM 381 18 74 67 33 122 67 rs1572573 Imputed A ADD 362 3 58 87 6 59 149 rs1572573 Imputed A DOM 362 3 58 87 6 59 149 rs1584003 Imputed C DOM 380 38 89 30 50 112 61 rs1584005 Imputed C DOM 380 38 89 30 50 112 61 rs1585771 Imputed G ADD 382 15 70 73 10 88 126 rs1592015 Imputed G DOM 383 4 32 123 7 61 156 rs1594885 Imputed A ADD 380 17 72 69 13 94 115 rs1603232 Imputed A DOM 370 35 62 56 47 125 45 rs1614565 Imputed C DOM 372 36 64 54 48 127 43 rs1648200 Imputed G ADD 363 9 70 71 6 83 124 rs16877387 Imputed C GEN 382 30 68 60 22 113 89 rs16877387 Imputed C REC 382 30 68 60 22 113 89 rs16938626 Imputed G DOM 382 9 55 94 17 104 103 rs1694334 Imputed G ADD 351 6 37 106 11 78 113 rs16998821 Imputed C DOM 383 4 32 123 7 61 156 rs1700400 Imputed T ADD 362 6 47 101 25 76 107 rs17007620 Imputed G ADD 363 13 64 73 9 71 133 rs17007620 Imputed G DOM 363 13 64 73 9 71 133 rs17023290 Imputed C DOM 383 0 41 118 1 27 196 rs17047957 Imputed C DOM 383 5 42 112 3 41 180 rs1705237 Imputed A DOM 369 36 62 54 48 126 43 rs1705261 Imputed A GEN 383 40 68 51 34 117 73 rs1705261 Imputed A REC 383 40 68 51 34 117 73 rs17076972 Imputed C ADD 383 44 77 38 38 117 69 rs17076972 Imputed C GEN 383 44 77 38 38 117 69 rs17076972 Imputed C REC 383 44 77 38 38 117 69 rs17189710 Imputed T ADD 383 27 75 57 29 87 108 rs17189710 Imputed T GEN 383 27 75 57 29 87 108 rs17196143 Imputed A ADD 383 10 53 96 4 64 156 rs17353809 Imputed G ADD 382 11 66 81 6 76 142 rs17368986 Imputed A GEN 381 11 46 102 6 68 148 rs17369097 Imputed A GEN 383 12 45 102 6 70 148 rs17434511 Imputed C GEN 383 11 46 102 6 69 149 rs17434589 Imputed C GEN 376 11 44 100 6 69 146 rs17434603 Imputed G GEN 383 11 46 102 6 69 149 rs17434840 Imputed C GEN 383 12 45 102 6 70 148 rs17446418 Imputed G DOM 382 22 67 70 35 110 78 rs17530747 Imputed T DOM 382 22 67 70 35 110 78 rs17604285 Imputed C ADD 383 0 20 139 2 54 168 rs17604285 Imputed C DOM 383 0 20 139 2 54 168 rs17662322 Imputed T DOM 383 5 45 109 8 82 134 rs17769826 Imputed T ADD 382 11 66 81 6 76 142 rs17821641 Imputed T ADD 379 10 65 82 6 74 142 rs1782328 Imputed A ADD 356 3 35 112 6 75 125 rs1796337 Imputed T DOM 379 37 68 53 56 119 46 rs1798083 Imputed C DOM 370 35 64 54 48 126 43 rs1798085 Imputed T DOM 372 36 64 54 48 127 43 rs1798086 Imputed T DOM 370 36 63 54 48 126 43 rs1798089 Imputed C GEN 371 46 64 42 41 110 68 rs1798089 Imputed C REC 371 46 64 42 41 110 68 rs1798090 Imputed C GEN 371 46 65 41 41 110 68 rs1798090 Imputed C REC 371 46 65 41 41 110 68 rs1832222 Imputed G DOM 382 16 68 74 20 84 120 rs1838104 Imputed A ADD 370 38 66 50 69 109 38 rs1838104 Imputed A GEN 370 38 66 50 69 109 38 rs1868616 Imputed G ADD 372 4 46 105 8 82 127 rs1874313 Imputed A DOM 382 18 74 67 33 123 67 rs1884902 Imputed C REC 379 26 70 61 22 114 86 rs1913201 Imputed G ADD 383 26 68 65 38 124 62 rs1913201 Imputed G DOM 383 26 68 65 38 124 62 rs1913201 Imputed G GEN 383 26 68 65 38 124 62 rs1944279 Imputed A ADD 377 17 71 69 12 94 114 rs198461 Imputed C DOM 382 40 69 50 61 121 41 rs1987179 Imputed T DOM 383 10 44 105 10 87 127 rs1990023 Imputed T DOM 382 18 53 87 24 105 95 rs2016194 Imputed G DOM 381 17 56 85 24 107 92 rs2024789 Imputed C ADD 381 31 80 47 60 112 51 rs2024789 Imputed C GEN 381 31 80 47 60 112 51 rs2024902 Imputed A ADD 382 0 27 131 1 15 208 rs2024902 Imputed A DOM 382 0 27 131 1 15 208 rs2025107 Imputed A ADD 382 1 28 129 2 14 208 rs2025107 Imputed A DOM 382 1 28 129 2 14 208 rs2025108 Imputed T ADD 382 1 28 129 2 14 208 rs2025108 Imputed T DOM 382 1 28 129 2 14 208 rs2062448 Imputed T ADD 383 0 20 139 2 54 168 rs2062448 Imputed T DOM 383 0 20 139 2 54 168 rs2063591 Imputed C ADD 382 27 69 62 40 124 60 rs2063591 Imputed C DOM 382 27 69 62 40 124 60 rs2065604 Imputed C DOM 383 2 16 141 3 44 177 rs2066238 Imputed T DOM 383 4 32 123 7 61 156 rs2068051 Imputed G ADD 264 20 60 31 38 88 27 rs2068051 Imputed G GEN 264 20 60 31 38 88 27 rs2077702 Genotyped G GEN 383 27 73 59 25 112 87 rs208757 Imputed G ADD 345 5 48 91 6 51 144 rs208757 Imputed G DOM 345 5 48 91 6 51 144 rs2095586 Imputed A DOM 382 16 68 74 20 84 120 rs2108426 Imputed C DOM 381 17 55 86 24 106 93 rs2110664 Imputed A DOM 349 18 62 64 16 71 118 rs2132242 Imputed A DOM 382 18 74 67 33 122 68 rs2151644 Imputed T DOM 383 2 16 141 3 44 177 rs2157752 Genotyped A GEN 383 11 74 74 27 105 92 rs2158958 Imputed A DOM 383 17 56 86 24 107 93 rs2158961 Imputed G DOM 383 17 55 87 24 105 95 rs2164099 Imputed G ADD 382 17 72 70 13 94 116 rs2173254 Imputed G GEN 381 7 81 70 25 103 95 rs2173254 Imputed G REC 381 7 81 70 25 103 95 rs2188079 Imputed C ADD 383 32 82 45 28 107 89 rs2188079 Imputed C GEN 383 32 82 45 28 107 89 rs2190304 Imputed G REC 383 27 83 49 55 99 70 rs2190597 Imputed T DOM 381 29 73 55 40 117 67 rs2190598 Imputed T DOM 383 17 56 86 24 107 93 rs2190600 Imputed A DOM 379 17 55 84 24 107 92 rs2218084 Imputed T GEN 383 6 55 98 2 59 163 rs2218084 Imputed T REC 383 6 55 98 2 59 163 rs2236290 Genotyped C GEN 381 17 73 68 37 106 80 rs2243860 Imputed A GEN 306 21 55 47 17 84 82 rs2243860 Imputed A REC 306 21 55 47 17 84 82 rs2246564 Imputed T DOM 383 2 16 141 3 44 177 rs2248236 Imputed C DOM 383 10 44 105 10 87 127 rs2250340 Imputed T DOM 333 2 16 119 3 44 149 rs2257192 Imputed G DOM 383 2 16 141 3 44 177 rs2270584 Imputed A DOM 382 18 71 69 33 122 69 rs2270586 Imputed A DOM 371 18 72 62 33 125 61 rs2270589 Imputed A ADD 308 25 58 45 37 109 34 rs2270589 Imputed A DOM 308 25 58 45 37 109 34 rs2270589 Imputed A GEN 308 25 58 45 37 109 34 rs2296889 Imputed C DOM 381 7 49 103 3 47 172 rs2301346 Imputed C ADD 343 12 78 56 13 73 111 rs2301346 Imputed C DOM 343 12 78 56 13 73 111 rs2327929 Imputed G REC 383 42 68 49 38 120 66 rs2357486 Imputed C REC 379 14 77 67 12 116 93 rs2373793 Imputed G DOM 374 4 61 88 8 59 154 rs2377622 Imputed T GEN 283 9 48 60 23 73 70 rs2377622 Imputed T REC 283 9 48 60 23 73 70 rs2383903 Imputed G DOM 381 9 56 93 17 104 102 rs2389866 Imputed C DOM 383 10 44 105 10 87 127 rs2389869 Imputed C DOM 383 10 44 105 10 87 127 rs2418541 Imputed A DOM 383 18 54 87 24 105 95 rs2418542 Imputed A DOM 383 18 54 87 24 105 95 rs2418548 Imputed C DOM 378 19 55 83 25 104 92 rs2476976 Imputed C DOM 382 16 68 74 20 84 120 rs2483639 Imputed A DOM 383 2 16 141 3 44 177 rs2483640 Imputed A DOM 383 2 16 141 3 44 177 rs2544780 Imputed T REC 381 20 61 76 17 108 99 rs2586458 Imputed T DOM 323 2 24 115 3 59 120 rs2593272 Imputed G ADD 383 7 51 101 28 84 112 rs2593273 Imputed T ADD 383 7 51 101 28 84 112 rs2622499 Imputed G DOM 383 10 44 105 10 87 127 rs264126 Imputed C DOM 381 30 71 56 40 115 69 rs264129 Imputed T DOM 383 17 55 87 24 105 95 rs2656822 Imputed T ADD 383 7 51 101 28 84 112 rs2656823 Imputed G ADD 383 7 51 101 28 84 112 rs2656825 Imputed T ADD 362 3 48 101 20 79 111 rs2764766 Imputed C REC 383 21 62 76 17 108 99 rs2793101 Imputed T ADD 383 1 25 133 1 53 170 rs2793101 Imputed T DOM 383 1 25 133 1 53 170 rs2795871 Imputed A ADD 382 0 12 147 0 40 183 rs2795886 Imputed A ADD 383 0 10 149 0 36 188 rs2795886 Imputed A DOM 383 0 10 149 0 36 188 rs2859994 Imputed C GEN 378 33 81 42 28 114 80 rs2870464 Imputed G DOM 383 2 31 126 2 33 189 rs2875528 Imputed T DOM 383 0 41 118 1 27 196 rs2876227 Imputed C ADD 380 27 74 55 30 90 104 rs2876227 Imputed C GEN 380 27 74 55 30 90 104 rs2882097 Imputed A DOM 383 16 69 74 20 84 120 rs2921983 Imputed C ADD 375 6 48 101 27 81 112 rs2987537 Imputed C DOM 383 2 25 132 4 54 166 rs2996416 Imputed C ADD 382 1 20 137 3 46 175 rs2996416 Imputed C DOM 382 1 20 137 3 46 175 rs3015527 Imputed C ADD 377 1 20 135 3 45 173 rs3015527 Imputed C DOM 377 1 20 135 3 45 173 rs3015530 Imputed C ADD 383 1 20 138 3 46 175 rs3015530 Imputed C DOM 383 1 20 138 3 46 175 rs3015531 Imputed T ADD 383 1 20 138 3 46 175 rs3015531 Imputed T DOM 383 1 20 138 3 46 175 rs3015535 Imputed C ADD 383 1 20 138 3 46 175 rs3015535 Imputed C DOM 383 1 20 138 3 46 175 rs3019407 Imputed A GEN 381 7 81 70 26 101 96 rs3019407 Imputed A REC 381 7 81 70 26 101 96 rs36071725 Genotyped C GEN 383 24 78 57 24 96 104 rs373983 Imputed G DOM 380 24 84 49 38 104 81 rs3756154 Imputed C DOM 383 10 44 105 10 87 127 rs3793044 Imputed C ADD 383 0 27 132 1 15 208 rs3793044 Imputed C DOM 383 0 27 132 1 15 208 rs3793053 Imputed C ADD 380 1 27 130 2 14 206 rs3793053 Imputed C DOM 380 1 27 130 2 14 206 rs3796246 Imputed G ADD 383 0 17 142 3 52 169 rs3796246 Imputed G DOM 383 0 17 142 3 52 169 rs3805996 Imputed G ADD 382 0 27 131 1 15 208 rs3805996 Imputed G DOM 382 0 27 131 1 15 208 rs3806003 Imputed A ADD 383 0 27 132 1 15 208 rs3806003 Imputed A DOM 383 0 27 132 1 15 208 rs3806004 Imputed T ADD 382 1 29 128 2 14 208 rs3806004 Imputed T DOM 382 1 29 128 2 14 208 rs3806010 Imputed T ADD 382 1 28 129 2 14 208 rs3806010 Imputed T DOM 382 1 28 129 2 14 208 rs3806014 Imputed T ADD 382 1 28 129 2 14 208 rs3806014 Imputed T DOM 382 1 28 129 2 14 208 rs3806015 Imputed A ADD 382 1 28 129 2 14 208 rs3806015 Imputed A DOM 382 1 28 129 2 14 208 rs3806018 Imputed A ADD 382 1 28 129 2 14 208 rs3806018 Imputed A DOM 382 1 28 129 2 14 208 rs3806019 Imputed A ADD 382 1 28 129 2 14 208 rs3806019 Imputed A DOM 382 1 28 129 2 14 208 rs3806024 Imputed T ADD 382 1 27 131 2 14 207 rs3806024 Imputed T DOM 382 1 27 131 2 14 207 rs3847825 Imputed G ADD 382 21 69 68 36 115 73 rs3847825 Imputed G GEN 382 21 69 68 36 115 73 rs3852001 Genotyped C GEN 383 12 45 102 6 70 148 rs3852001 Genotyped C REC 383 12 45 102 6 70 148 rs3852002 Imputed G GEN 383 12 45 102 6 70 148 rs3852002 Imputed G REC 383 12 45 102 6 70 148 rs3852003 Imputed A GEN 383 12 45 102 6 70 148 rs3852003 Imputed A REC 383 12 45 102 6 70 148 rs3942254 Imputed T DOM 351 18 61 64 33 109 66 rs3945085 Imputed A DOM 383 16 69 74 19 84 121 rs399485 Imputed A DOM 382 15 77 67 20 92 111 rs4029119 Imputed G ADD 382 0 1 157 0 11 213 rs4029119 Imputed G DOM 382 0 1 157 0 11 213 rs412791 Imputed C GEN 367 13 73 70 28 99 84 rs4146972 Genotyped T DOM 383 5 42 112 3 42 179 rs4259369 Imputed C REC 383 21 85 53 60 112 52 rs4273613 Imputed T ADD 383 0 2 157 0 11 213 rs4273613 Imputed T DOM 383 0 2 157 0 11 213 rs4294022 Imputed C DOM 383 9 50 100 11 102 111 rs4310554 Genotyped C DOM 383 51 81 27 62 105 57 rs4315598 Imputed T ADD 382 27 75 57 29 87 107 rs4315598 Imputed T GEN 382 27 75 57 29 87 107 rs4370878 Imputed G DOM 383 16 69 74 19 84 121 rs4436200 Imputed C ADD 383 0 30 129 7 54 163 rs4444612 Imputed G ADD 383 27 75 57 29 87 108 rs4444612 Imputed G GEN 383 27 75 57 29 87 108 rs4450660 Imputed C DOM 383 6 67 86 9 65 150 rs4463950 Imputed C DOM 379 27 64 67 53 104 64 rs4509702 Imputed C DOM 383 16 69 74 19 84 121 rs4533379 Imputed G ADD 380 17 72 69 13 94 115 rs4569984 Imputed A DOM 374 9 49 98 10 103 105 rs4570530 Imputed C DOM 383 16 69 74 19 84 121 rs4571583 Imputed T DOM 383 9 49 101 10 103 111 rs4586678 Imputed A DOM 383 6 67 86 9 65 150 rs4615971 Imputed C DOM 382 16 68 74 20 84 120 rs4629229 Imputed G DOM 383 4 32 123 7 61 156 rs4632512 Imputed T GEN 383 12 45 102 6 70 148 rs4641552 Imputed A ADD 377 1 19 136 2 48 171 rs4682527 Imputed C DOM 364 19 86 48 20 97 94 rs4688632 Imputed G REC 373 37 77 40 72 94 53 rs4702720 Imputed A ADD 320 3 38 92 11 62 114 rs4702720 Imputed A DOM 320 3 38 92 11 62 114 rs4714484 Imputed A ADD 383 6 32 121 12 74 138 rs4714484 Imputed A DOM 383 6 32 121 12 74 138 rs4725142 Genotyped G REC 383 10 83 66 34 91 99 rs4725144 Imputed G REC 383 10 83 66 34 91 99 rs4760785 Imputed A ADD 383 26 68 65 38 124 62 rs4760785 Imputed A DOM 383 26 68 65 38 124 62 rs4760894 Imputed T ADD 383 26 68 65 38 124 62 rs4760894 Imputed T DOM 383 26 68 65 38 124 62 rs4760895 Imputed A ADD 383 26 68 65 38 124 62 rs4760895 Imputed A DOM 383 26 68 65 38 124 62 rs4767184 Imputed C ADD 375 21 66 67 36 114 71 rs4767184 Imputed C GEN 375 21 66 67 36 114 71 rs4773487 Imputed T ADD 380 1 20 136 3 48 172 rs4780547 Imputed G GEN 382 5 58 95 14 77 133 rs4780547 Imputed G REC 382 5 58 95 14 77 133 rs483159 Imputed T DOM 369 5 56 91 9 67 141 rs4836502 Imputed T DOM 383 17 56 86 24 107 93 rs4836507 Imputed C DOM 376 17 54 84 24 105 92 rs4851531 Imputed T DOM 380 24 63 71 30 122 70 rs4879931 Imputed G ADD 382 12 68 79 22 110 91 rs489441 Imputed G ADD 357 16 69 62 12 86 112 rs489441 Imputed G DOM 357 16 69 62 12 86 112 rs4976276 Imputed T ADD 382 24 83 51 23 98 103 rs4977681 Imputed C REC 380 23 73 61 17 112 94 rs4986197 Imputed G ADD 379 17 71 69 13 94 115 rs4986220 Imputed T ADD 383 17 71 71 12 95 117 rs525462 Imputed A GEN 382 45 82 32 93 103 27 rs552006 Imputed G GEN 380 16 68 75 8 91 122 rs5756669 Imputed C DOM 383 27 88 44 43 97 84 rs581905 Imputed T DOM 383 1 27 131 2 29 193 rs6033138 Imputed C ADD 383 27 75 57 29 87 108 rs6033138 Imputed C GEN 383 27 75 57 29 87 108 rs6040619 Imputed C ADD 374 27 74 55 28 87 103 rs6040619 Imputed C GEN 374 27 74 55 28 87 103 rs6040625 Imputed T ADD 380 27 73 56 28 88 108 rs6040625 Imputed T GEN 380 27 73 56 28 88 108 rs6040630 Imputed A ADD 383 27 75 57 28 88 108 rs6040630 Imputed A GEN 383 27 75 57 28 88 108 rs6040633 Imputed A ADD 383 27 75 57 29 87 108 rs6040633 Imputed A GEN 383 27 75 57 29 87 108 rs6040634 Imputed T ADD 383 27 75 57 29 87 108 rs6040634 Imputed T GEN 383 27 75 57 29 87 108 rs6040636 Imputed T ADD 383 27 75 57 29 87 108 rs6040636 Imputed T GEN 383 27 75 57 29 87 108 rs6040638 Imputed C ADD 383 27 75 57 29 87 108 rs6040638 Imputed C GEN 383 27 75 57 29 87 108 rs6040644 Imputed A ADD 383 27 75 57 29 87 108 rs6040644 Imputed A GEN 383 27 75 57 29 87 108 rs6040667 Imputed T ADD 381 27 73 57 29 87 108 rs6040667 Imputed T GEN 381 27 73 57 29 87 108 rs6040668 Imputed C ADD 381 27 73 57 29 87 108 rs6040668 Imputed C GEN 381 27 73 57 29 87 108 rs6053005 Imputed C DOM 283 37 50 31 68 78 19 rs6054405 Imputed A REC 379 26 70 61 22 114 86 rs6054427 Genotyped G GEN 383 28 81 50 25 117 82 rs6075186 Imputed G DOM 383 4 32 123 7 61 156 rs608278 Imputed A ADD 345 24 75 46 55 99 46 rs6111540 Imputed A ADD 347 30 69 47 48 110 43 rs6131206 Imputed C ADD 380 22 70 65 21 83 119 rs6131208 Imputed T ADD 381 27 73 57 29 87 108 rs6131208 Imputed T GEN 381 27 73 57 29 87 108 rs6131919 Imputed G DOM 383 4 32 123 7 61 156 rs6134243 Imputed C ADD 383 27 75 57 29 87 108 rs6134243 Imputed C GEN 383 27 75 57 29 87 108 rs6136020 Imputed A DOM 383 4 32 123 7 61 156 rs613799 Imputed C DOM 373 16 67 69 20 83 118 rs644041 Imputed G ADD 349 16 66 58 12 86 111 rs644041 Imputed G DOM 349 16 66 58 12 86 111 rs6464377 Imputed C DOM 383 0 28 131 2 23 199 rs6474230 Imputed T DOM 383 14 62 83 8 66 150 rs6476565 Imputed A DOM 383 2 16 141 3 44 177 rs6511286 Imputed T ADD 382 22 74 63 14 91 118 rs6541829 Genotyped C REC 383 18 59 82 9 97 118 rs6544721 Imputed G DOM 383 12 69 78 12 70 142 rs6544728 Imputed T DOM 377 6 65 86 8 61 151 rs6565910 Imputed G DOM 383 5 53 101 13 92 119 rs6581985 Imputed G GEN 383 22 65 72 15 107 102 rs6581985 Imputed G REC 383 22 65 72 15 107 102 rs6685186 Imputed T ADD 383 27 81 51 28 102 94 rs6685186 Imputed T GEN 383 27 81 51 28 102 94 rs670593 Imputed A REC 383 20 76 63 43 103 78 rs6722640 Imputed T DOM 382 25 64 70 30 123 70 rs6746170 Imputed A DOM 380 6 65 87 8 61 153 rs6757316 Imputed A GEN 380 37 82 39 42 100 80 rs6805139 Imputed G DOM 376 41 78 36 51 96 74 rs6808571 Imputed G ADD 378 6 47 105 3 54 163 rs6816479 Imputed A REC 383 35 76 48 25 111 88 rs6865976 Imputed C DOM 305 25 61 44 41 96 38 rs687047 Imputed C ADD 383 2 29 128 4 53 167 rs6871041 Imputed G DOM 367 14 52 87 20 99 95 rs688358 Imputed A ADD 382 2 28 128 5 52 167 rs6908481 Imputed C REC 375 40 64 51 35 126 59 rs6917224 Imputed A ADD 382 43 63 52 37 101 86 rs6917224 Imputed A GEN 382 43 63 52 37 101 86 rs6920677 Imputed G DOM 380 12 76 69 45 113 65 rs6994498 Imputed G DOM 383 14 62 83 8 66 150 rs6998772 Imputed T DOM 383 1 14 144 2 6 216 rs7022281 Imputed C ADD 382 18 78 63 36 118 69 rs7022281 Imputed C GEN 382 18 78 63 36 118 69 rs7022281 Imputed C REC 382 18 78 63 36 118 69 rs7043983 Imputed T DOM 383 2 16 141 3 44 177 rs7077799 Imputed A DOM 382 16 69 74 20 84 119 rs7088947 Imputed A ADD 383 0 12 147 0 41 183 rs7089661 Imputed C DOM 382 16 68 74 20 84 120 rs7102072 Imputed A DOM 381 12 56 90 21 101 101 rs710832 Genotyped A REC 383 4 69 86 19 83 122 rs712531 Imputed A DOM 371 19 87 49 19 100 97 rs7129817 Imputed T ADD 383 15 64 80 32 104 88 rs7134262 Imputed T GEN 383 27 74 58 23 115 86 rs7134262 Imputed T REC 383 27 74 58 23 115 86 rs7138300 Imputed C ADD 383 26 68 65 38 124 62 rs7138300 Imputed C DOM 383 26 68 65 38 124 62 rs722927 Imputed G ADD 383 0 15 144 1 41 182 rs722927 Imputed G DOM 383 0 15 144 1 41 182 rs726424 Genotyped G ADD 383 21 69 69 36 115 73 rs726424 Genotyped G GEN 383 21 69 69 36 115 73 rs7295817 Imputed C ADD 381 22 70 65 40 115 69 rs7295817 Imputed C GEN 381 22 70 65 40 115 69 rs7295817 Imputed C REC 381 22 70 65 40 115 69 rs7297372 Imputed A ADD 338 29 79 28 54 119 29 rs7297372 Imputed A GEN 338 29 79 28 54 119 29 rs7298255 Imputed A ADD 382 25 68 65 38 124 62 rs7298255 Imputed A DOM 382 25 68 65 38 124 62 rs7305832 Imputed C GEN 383 27 74 58 23 115 86 rs7305832 Imputed C REC 383 27 74 58 23 115 86 rs737542 Imputed A REC 381 18 59 81 8 97 118 rs742827 Imputed A ADD 361 27 71 53 29 82 99 rs742827 Imputed A GEN 361 27 71 53 29 82 99 rs7446891 Imputed G DOM 373 16 53 86 22 103 93 rs7448641 Imputed C ADD 383 0 2 157 0 11 213 rs7448641 Imputed C DOM 383 0 2 157 0 11 213 rs7460605 Imputed G DOM 361 26 76 50 36 85 88 rs7468898 Imputed T ADD 379 34 83 40 31 106 85 rs7468898 Imputed T GEN 379 34 83 40 31 106 85 rs7501186 Imputed A DOM 383 4 36 119 2 44 178 rs755117 Imputed A DOM 375 7 56 93 6 55 158 rs7557560 Imputed T GEN 383 17 44 98 4 68 152 rs7557560 Imputed T REC 383 17 44 98 4 68 152 rs7562462 Imputed T DOM 380 35 89 34 43 112 67 rs757173 Genotyped G DOM 383 22 67 70 35 111 78 rs7607447 Imputed T REC 332 19 57 63 14 89 90 rs7639053 Imputed A ADD 383 11 66 82 6 76 142 rs7648163 Imputed C REC 358 27 64 59 15 102 91 rs7651273 Imputed A GEN 383 11 46 102 6 69 149 rs7653190 Imputed C ADD 382 11 66 81 6 76 142 rs7653685 Genotyped C DOM 383 0 41 118 2 26 196 rs7684899 Imputed C DOM 383 10 44 105 10 87 127 rs7701604 Imputed G ADD 383 0 2 157 0 11 213 rs7701604 Imputed G DOM 383 0 2 157 0 11 213 rs7703676 Imputed C ADD 383 0 2 157 0 11 213 rs7703676 Imputed C DOM 383 0 2 157 0 11 213 rs7711358 Imputed A DOM 383 18 54 87 24 105 95 rs7713251 Imputed C REC 367 26 66 60 16 104 95 rs7737608 Imputed G DOM 382 29 83 46 40 98 86 rs7755903 Imputed A GEN 382 17 82 60 52 105 66 rs7762993 Imputed A ADD 378 3 59 95 6 60 155 rs7762993 Imputed A DOM 378 3 59 95 6 60 155 rs7767265 Imputed G DOM 382 9 61 89 12 64 147 rs7769415 Imputed C GEN 376 22 63 71 19 102 99 rs7771264 Imputed T DOM 383 9 50 100 11 102 111 rs7795792 Imputed T REC 383 21 85 53 60 112 52 rs7806481 Imputed G REC 383 27 83 49 55 99 70 rs7808536 Imputed G DOM 383 7 62 90 7 57 160 rs7814819 Imputed G ADD 225 0 17 72 1 14 121 rs7814819 Imputed G DOM 225 0 17 72 1 14 121 rs7815952 Imputed T DOM 383 1 14 144 2 6 216 rs7834090 Imputed T DOM 383 1 14 144 2 6 216 rs7859250 Imputed C DOM 383 2 16 141 3 44 177 rs7863577 Genotyped A ADD 383 1 17 141 2 40 182 rs7863577 Genotyped A DOM 383 1 17 141 2 40 182 rs7902140 Imputed C ADD 378 3 35 117 6 75 142 rs7921834 Imputed C DOM 382 16 68 74 20 84 120 rs7939893 Imputed C ADD 382 20 66 73 24 116 83 rs7939893 Imputed C DOM 382 20 66 73 24 116 83 rs7955901 Imputed C ADD 383 26 68 65 38 124 62 rs7955901 Imputed C DOM 383 26 68 65 38 124 62 rs7956274 Imputed T ADD 382 25 68 65 38 124 62 rs7956274 Imputed T DOM 382 25 68 65 38 124 62 rs7957932 Imputed G ADD 380 27 68 62 40 124 59 rs7957932 Imputed G DOM 380 27 68 62 40 124 59 rs7984294 Imputed A DOM 341 0 16 127 0 11 187 rs7994286 Imputed A ADD 377 1 20 136 3 46 171 rs7994286 Imputed A DOM 377 1 20 136 3 46 171 rs8038229 Genotyped A ADD 383 11 56 92 28 99 97 rs8038229 Genotyped A DOM 383 11 56 92 28 99 97 rs8043336 Imputed C GEN 370 9 74 71 31 104 81 rs8043336 Imputed C REC 370 9 74 71 31 104 81 rs8054431 Imputed T DOM 372 22 88 46 22 94 100 rs8066502 Imputed T DOM 383 6 36 117 6 72 146 rs8068714 Imputed T DOM 383 6 37 116 6 72 146 rs892575 Imputed T ADD 383 17 72 70 13 95 116 rs892583 Imputed G ADD 383 17 71 71 12 95 117 rs915494 Imputed A ADD 374 16 63 74 19 83 119 rs915494 Imputed A DOM 374 16 63 74 19 83 119 rs917295 Imputed G DOM 383 17 56 86 24 107 93 rs922594 Imputed T DOM 375 15 63 77 25 113 82 rs9301653 Imputed T ADD 383 1 20 138 3 46 175 rs9301653 Imputed T DOM 383 1 20 138 3 46 175 rs9309988 Imputed G DOM 383 0 41 118 2 26 196 rs9309989 Genotyped C DOM 383 0 41 118 2 26 196 rs9310221 Imputed A DOM 352 17 84 43 37 89 82 rs9327555 Imputed T DOM 383 17 56 86 24 107 93 rs937890 Imputed G DOM 383 6 37 116 6 72 146 rs9454967 Imputed G ADD 382 1 28 129 2 14 208 rs9454967 Imputed G DOM 382 1 28 129 2 14 208 rs9471295 Imputed T DOM 383 2 49 108 8 45 171 rs9477007 Imputed A ADD 380 42 67 50 37 100 84 rs9477007 Imputed A GEN 380 42 67 50 37 100 84 rs9487279 Imputed T DOM 366 13 77 62 38 115 61 rs949016 Imputed C ADD 383 17 71 71 12 95 117 rs9555973 Imputed G ADD 379 1 19 136 3 45 175 rs9555973 Imputed G DOM 379 1 19 136 3 45 175 rs9557510 Imputed G ADD 383 6 48 105 6 44 174 rs9557510 Imputed G DOM 383 6 48 105 6 44 174 rs9560584 Imputed T DOM 382 1 20 137 3 46 175 rs9588770 Imputed T DOM 381 1 18 139 3 46 174 rs9588848 Imputed C ADD 383 1 20 138 3 46 175 rs9588848 Imputed C DOM 383 1 20 138 3 46 175 rs966583 Imputed A ADD 382 19 73 67 34 122 67 rs966583 Imputed A DOM 382 19 73 67 34 122 67 rs974130 Genotyped A REC 383 35 76 48 25 111 88 rs977160 Imputed T ADD 382 17 67 75 12 92 119 rs9812206 Imputed G ADD 383 0 19 140 3 53 168 rs9812206 Imputed G DOM 383 0 19 140 3 53 168 rs9813552 Imputed G ADD 379 0 18 139 3 51 168 rs9813552 Imputed G DOM 379 0 18 139 3 51 168 rs9815037 Imputed T ADD 382 0 18 141 3 51 169 rs9815037 Imputed T DOM 382 0 18 141 3 51 169 rs9825349 Imputed A ADD 382 0 18 141 3 51 169 rs9825349 Imputed A DOM 382 0 18 141 3 51 169 rs9834217 Imputed T ADD 382 0 18 141 3 51 169 rs9834217 Imputed T DOM 382 0 18 141 3 51 169 rs9840460 Imputed T ADD 382 0 18 141 3 51 169 rs9840460 Imputed T DOM 382 0 18 141 3 51 169 rs9840756 Imputed A ADD 380 0 18 140 3 51 168 rs9840756 Imputed A DOM 380 0 18 140 3 51 168 rs9844801 Imputed C DOM 383 0 41 118 1 27 196 rs985375 Imputed A GEN 374 15 65 74 9 85 126 rs9869187 Imputed C ADD 383 0 19 140 3 49 172 rs9869187 Imputed C DOM 383 0 19 140 3 49 172 rs9872327 Imputed T DOM 383 0 41 118 1 27 196 rs9881685 Imputed A ADD 379 0 18 138 2 53 168 rs9881685 Imputed A DOM 379 0 18 138 2 53 168 rs9909499 Imputed C DOM 362 7 76 68 13 81 117 rs9911847 Imputed G DOM 382 6 36 116 6 72 146 rs9946886 Imputed G REC 156 6 31 36 17 36 30 rs9958823 Imputed A ADD 377 17 71 69 12 94 114 rs9965248 Imputed T ADD 379 17 70 70 13 94 115

TABLE 11 ALLELE SNP rs # SOURCE (A1) MODEL NMISS OR SE L95 U95 STAT P HW_PVALUE ALLELE_FREQ ATORVA_ALLELE_FREQ PRAVA_ALLELE_FREQ rs198460 Genotyped G REC 443 1.956 0.2218 1.267 3.021 3.026 0.00248 1 0.51129 0.56021 0.47421 rs603940 Genotyped G REC 443 0.3862 0.3119 0.2095 0.7117 −3.05 0.00229 0.9214 0.39955 0.37958 0.41468 rs10021016 Genotyped G GEN 443 6.477 0.03922 0.7144 0.26298 0.29843 0.23611 rs1003148 Imputed C ADD 427 0.7405 0.1452 0.5572 0.9843 −2.069 0.03853 0.9214 0.42974 0.38798 0.46107 rs1003148 Imputed C GEN 427 6.652 0.03594 0.9214 0.42974 0.38798 0.46107 rs1003148 Imputed C REC 427 0.4879 0.2786 0.2826 0.8423 −2.576 0.01 0.9214 0.42974 0.38798 0.46107 rs10046799 Imputed C ADD 440 0.7946 0.1374 0.607 1.04 −1.672 0.09444 0.4976 0.5625 0.5291 0.58765 rs10046799 Imputed C GEN 440 9.736 0.00769 0.4976 0.5625 0.5291 0.58765 rs10051148 Imputed C DOM 443 0.6399 0.1948 0.4368 0.9373 −2.293 0.02187 0.8242 0.30813 0.2801 0.32937 rs10054055 Imputed T DOM 440 0.5872 0.2006 0.3963 0.8702 −2.653 0.00797 0.3313 0.32841 0.29365 0.35458 rs10067895 Imputed A DOM 440 0.577 0.2025 0.388 0.8581 −2.716 0.00661 0.07522 0.34886 0.31316 0.376 rs1008705 Imputed C DOM 353 2.01 0.2249 1.294 3.124 3.106 0.0019 0.6981 0.28895 0.32667 0.26108 rs10105871 Imputed C DOM 382 1.492 0.219 0.9712 2.291 1.827 0.06776 0.1311 0.38351 0.41212 0.36175 rs10116807 Imputed A GEN 436 7.758 0.02068 0.8866 0.21216 0.25263 0.18089 rs10116807 Imputed A REC 436 2.869 0.4949 1.087 7.568 2.129 0.03322 0.8866 0.21216 0.25263 0.18089 rs10121941 Imputed C DOM 443 1.177 0.2597 0.7077 1.959 6.29E−01 0.5296 0.5598 0.08691 0.09424 0.08135 rs10128638 Genotyped G DOM 443 0.6667 0.2297 0.425 1.046 −1.765 0.07748 1 0.52483 0.49738 0.54563 rs1012924 Imputed G ADD 438 1.725 0.2225 1.115 2.668 2.451 0.01426 0.1759 0.11872 0.14894 0.096 rs1012924 Imputed G DOM 438 1.754 0.2318 1.113 2.762 2.423 0.01539 0.1759 0.11872 0.14894 0.096 rs1016030 Genotyped G ADD 442 1.159 0.1474 0.8678 1.547 0.9985 0.318 1 0.36425 0.3822 0.3506 rs1016030 Genotyped G GEN 442 1.088 0.5805 1 0.36425 0.3822 0.3506 rs1017558 Imputed A REC 430 0.7905 0.293 0.4452 1.404 −0.8024 0.4223 0.3984 0.35349 0.32787 0.37247 rs10183431 Imputed T DOM 438 1.231 0.1969 0.8366 1.81 1.054 0.292 0.4508 0.25342 0.26064 0.248 rs10195401 Imputed C DOM 440 1.047 0.206 0.6991 1.568 0.2228 0.8237 0.112 0.4 0.40263 0.398 rs10239416 Imputed A DOM 431 1.361 0.2052 0.9105 2.035 1.503 0.1328 0.8386 0.38399 0.41444 0.36066 rs1032188 Imputed G GEN 443 6.472 0.03932 0.5638 0.29007 0.27225 0.30357 rs1032188 Imputed G REC 443 0.3936 0.3872 0.1843 0.8406 −2.408 0.01603 0.5638 0.29007 0.27225 0.30357 rs10468988 Imputed G ADD 438 1.083 0.1637 0.7858 1.493 0.4879 0.6256 0.7885 0.23174 0.23947 0.22581 rs10478919 Imputed G DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.00954 0.1134 0.34312 0.3089 0.36905 rs10506623 Imputed C DOM 442 0.7185 0.204 0.4817 1.072 −1.621 0.1051 0.6908 0.3948 0.36316 0.41865 rs10506626 Imputed A DOM 443 0.6807 0.2015 0.4586 1.01 −1.909 0.05621 0.5504 0.39391 0.35602 0.42262 rs10509477 Imputed T DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.36911 0.30754 rs10511071 Imputed C DOM 443 0.8286 0.2404 0.5173 1.327 −0.7821 0.4342 0.8039 0.10722 0.09686 0.11508 rs10511072 Imputed G DOM 443 0.8286 0.2404 0.5173 1.327 −0.7821 0.4342 0.8039 0.10722 0.09686 0.11508 rs10511199 Imputed C ADD 442 1.021 0.1625 0.7424 1.404 0.1273 0.8987 0.8924 0.22624 0.22895 0.22421 rs10513283 Imputed G GEN 442 1.393 0.4984 0.6226 0.17534 0.19211 0.1627 rs10520072 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs1065639 Imputed C DOM 209 2.955 1.237 0.2613 33.41 0.8755 0.3813 1 0.00718 0.01111 0.0042 rs10733846 Imputed G ADD 435 0.8325 0.1945 0.5686 1.219 −0.9428 0.3458 0.4814 0.16207 0.14706 0.17339 rs10733846 Imputed G DOM 435 0.7557 0.2153 0.4955 1.152 −1.301 0.1933 0.4814 0.16207 0.14706 0.17339 rs10737390 Imputed T DOM 418 1.128 0.213 0.7431 1.712 0.5659 0.5715 0.3626 0.40909 0.41899 0.40167 rs10749293 Imputed G DOM 441 1.442 0.1947 0.9847 2.113 1.881 0.05998 0.1901 0.322 0.35789 0.29482 rs10752159 Imputed G DOM 442 1.434 0.2005 0.968 2.124 1.798 0.07223 0.5658 0.20814 0.22513 0.19522 rs10753760 Imputed T ADD 423 0.9252 0.1361 0.7085 1.208 −0.5713 0.5678 0.01675 0.41844 0.41081 0.42437 rs10753760 Imputed T GEN 423 0.3766 0.8284 0.01675 0.41844 0.41081 0.42437 rs10757887 Imputed C DOM 443 1.073 0.1955 0.7315 1.574 0.3608 0.7182 0.05609 0.2754 0.28272 0.26984 rs10758326 Imputed A ADD 440 0.6884 0.1481 0.515 0.9203 −2.521 0.01172 0.5467 0.38523 0.34211 0.418 rs10758326 Imputed A GEN 440 9.42 0.009 0.5467 0.38523 0.34211 0.418 rs10758326 Imputed A REC 440 0.3854 0.3129 0.2087 0.7116 −3.047 0.00231 0.5467 0.38523 0.34211 0.418 rs10762236 Genotyped G ADD 443 0.93 0.1858 0.6461 1.339 −0.3906 0.6961 0.5219 0.18172 0.17539 0.18651 rs10765769 Imputed C ADD 441 1.226 0.1457 0.9215 1.631 1.399 0.1618 0.8413 0.38776 0.4127 0.36905 rs10765769 Imputed C GEN 441 2.026 0.3632 0.8413 0.38776 0.4127 0.36905 rs10784891 Imputed C ADD 422 0.7472 0.1404 0.5675 0.9839 −2.076 0.03794 0.4305 0.4455 0.40489 0.47689 rs10784891 Imputed C DOM 422 0.7374 0.2125 0.4862 1.118 −1.433 0.1518 0.4305 0.4455 0.40489 0.47689 rs10787923 Imputed G DOM 439 1.448 0.1952 0.9878 2.123 1.897 0.05785 0.1572 0.32232 0.35904 0.29482 rs10787949 Imputed A DOM 442 1.352 0.1976 0.9177 1.991 1.525 0.1272 0.1377 0.33937 0.37173 0.31474 rs10787951 Imputed G DOM 441 1.349 0.1976 0.9157 1.987 1.514 0.1299 0.1364 0.339 0.37105 0.31474 rs10787983 Imputed C DOM 441 1.351 0.1964 0.9194 1.986 1.532 0.1255 0.1642 0.33447 0.36911 0.308 rs10788380 Imputed C ADD 438 1.318 0.1398 1.002 1.733 1.973 0.04851 0.9239 0.49658 0.53723 0.466 rs10788380 Imputed C DOM 438 1.663 0.2322 1.055 2.621 2.191 0.02847 0.9239 0.49658 0.53723 0.466 rs10788380 Imputed C GEN 438 4.897 0.08641 0.9239 0.49658 0.53723 0.466 rs10814418 Imputed G DOM 442 1.184 0.2598 0.7118 1.97 0.6512 0.5149 0.7613 0.0871 0.09474 0.08135 rs10831417 Imputed A ADD 443 1.151 0.1492 0.8595 1.543 0.9453 0.3445 0.6065 0.35779 0.37435 0.34524 rs10831417 Imputed A GEN 443 0.969 0.616 0.6065 0.35779 0.37435 0.34524 rs10831422 Imputed C ADD 441 1.164 0.1481 0.871 1.557 1.028 0.304 0.918 0.36281 0.38095 0.34921 rs10831422 Imputed C GEN 441 1.057 0.5895 0.918 0.36281 0.38095 0.34921 rs10862931 Imputed C GEN 439 6.025 0.04917 0.8337 0.34966 0.38158 0.3253 rs10865197 Imputed C DOM 438 1.231 0.1969 0.8366 1.81 1.054 0.292 0.4508 0.25342 0.26064 0.248 rs10871302 Imputed A DOM 443 2.011 0.2218 1.302 3.107 3.15 0.00163 0.4471 0.14447 0.17801 0.11905 rs10877463 Imputed C DOM 443 0.5826 0.1985 0.3948 0.8597 −2.722 0.0065 0.6802 0.36005 0.31675 0.39286 rs10877468 Imputed C DOM 442 0.5848 0.1985 0.3963 0.8629 −2.703 0.00688 0.6808 0.35973 0.31675 0.39243 rs10879240 Imputed C ADD 428 0.7296 0.1403 0.5542 0.9605 −2.247 0.02462 0.434 0.44743 0.40426 0.48125 rs10879242 Imputed A DOM 421 0.7102 0.2081 0.4724 1.068 −1.644 0.1001 0.9197 0.40855 0.37297 0.43644 rs10879245 Imputed G DOM 421 0.7102 0.2081 0.4724 1.068 −1.644 0.1001 0.9197 0.40855 0.37297 0.43644 rs10879249 Imputed T DOM 440 0.7247 0.2038 0.486 1.081 −1.58 0.1141 0.7662 0.39773 0.36579 0.422 rs10886452 Imputed A DOM 440 1.376 0.1972 0.9349 2.025 1.619 0.1055 0.1648 0.33523 0.37368 0.306 rs10886463 Imputed C DOM 442 1.352 0.1976 0.9177 1.991 1.525 0.1272 0.1118 0.3405 0.37435 0.31474 rs10886465 Imputed A DOM 441 1.355 0.1976 0.9197 1.995 1.536 0.1245 0.1364 0.339 0.37435 0.312 rs10886526 Imputed C DOM 439 1.364 0.197 0.9275 2.007 1.578 0.1146 0.2383 0.33257 0.36772 0.306 rs10902437 Imputed G ADD 393 1.494 0.1583 1.095 2.037 2.534 0.01127 0.6725 0.39186 0.43558 0.36087 rs10941126 Imputed G ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.07341 rs10941126 Imputed G DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.07341 rs10947871 Imputed A DOM 391 2.143 0.2487 1.316 3.49 3.065 0.00218 1 0.11893 0.15805 0.08756 rs10972978 Imputed G DOM 437 1.24 0.2619 0.7423 2.072 0.8222 0.4109 0.5546 0.08696 0.09626 0.08 rs10973012 Imputed A DOM 443 1.177 0.2597 0.7077 1.959 0.6286 0.5296 0.5598 0.08691 0.09424 0.08135 rs10974028 Genotyped G ADD 443 1.203 0.1904 0.8287 1.748 0.9728 0.3306 0.726 0.16027 0.17277 0.15079 rs10974028 Genotyped G DOM 443 1.224 0.2126 0.807 1.857 0.9516 0.3413 0.726 0.16027 0.17277 0.15079 rs11021302 Imputed A ADD 441 1.164 0.1481 0.871 1.557 1.028 0.304 0.918 0.36281 0.38095 0.34921 rs11021302 Imputed A GEN 441 1.057 0.5895 0.918 0.36281 0.38095 0.34921 rs11099644 Imputed G REC 430 0.7905 0.293 0.4452 1.404 −0.8024 0.4223 0.3984 0.35349 0.32787 0.37247 rs11138315 Imputed G ADD 443 0.5453 0.2248 0.351 0.8473 −2.697 0.00699 0.2265 0.13544 0.10209 0.16071 rs11149802 Imputed T DOM 443 2.011 0.2218 1.302 3.107 3.15 0.00163 0.4471 0.14447 0.17801 0.11905 rs1116596 Imputed T DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.00954 0.1134 0.34312 0.3089 0.36905 rs11178531 Imputed A ADD 439 0.7197 0.1371 0.5501 0.9416 −2.399 0.01643 0.3881 0.46811 0.42105 0.50402 rs11178531 Imputed A DOM 439 0.6936 0.2116 0.4581 1.05 −1.729 0.08386 0.3881 0.46811 0.42105 0.50402 rs11178575 Imputed C GEN 441 8.684 0.01301 0.3129 0.30385 0.3534 0.266 rs11178575 Imputed C REC 441 2.252 0.3587 1.115 4.549 2.263 0.02362 0.3129 0.30385 0.3534 0.266 rs11178577 Imputed T GEN 439 8.67 0.0131 0.2621 0.30752 0.35789 0.26908 rs11178577 Imputed T REC 439 2.243 0.3588 1.11 4.532 2.252 0.02435 0.2621 0.30752 0.35789 0.26908 rs11178583 Imputed A DOM 443 0.7338 0.2032 0.4927 1.093 −1.523 0.1277 0.6922 0.39503 0.36387 0.41865 rs11178589 Imputed T DOM 437 0.7215 0.2047 0.4831 1.078 −1.595 0.1108 0.8419 0.39931 0.36579 0.4251 rs11178594 Imputed C DOM 441 0.7044 0.202 0.4741 1.046 −1.735 0.08274 1 0.40249 0.36842 0.42829 rs11178602 Imputed T DOM 439 0.7005 0.2027 0.4709 1.042 −1.757 0.079 1 0.40205 0.36772 0.428 rs11178648 Imputed T DOM 440 0.6786 0.2027 0.4561 1.01 −1.912 0.05581 0.4852 0.39432 0.35714 0.42231 rs11198877 Imputed T DOM 441 1.369 0.1971 0.9302 2.014 1.593 0.1113 0.1996 0.3356 0.37368 0.30677 rs11198942 Imputed T DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.36911 0.30754 rs11221075 Imputed A ADD 417 0.4912 0.2448 0.304 0.7936 −2.904 0.00369 1 0.11391 0.07542 0.14286 rs11242020 Imputed T DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.00954 0.1134 0.34312 0.3089 0.36905 rs11242021 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs11242022 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs11242023 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs1149350 Imputed A DOM 443 0.8901 0.2092 0.5906 1.341 −0.5566 0.5778 0.01047 0.21445 0.18848 0.23413 rs1150143 Imputed G DOM 435 1.007 0.2015 0.6785 1.495 0.03498 0.9721 0.1573 0.38851 0.38978 0.38755 rs11576627 Imputed T ADD 441 1.439 0.1975 0.977 2.119 1.842 0.06547 0.01289 0.12358 0.15 0.10359 rs11576627 Imputed T DOM 441 1.57 0.2354 0.9899 2.491 1.917 0.05525 0.01289 0.12358 0.15 0.10359 rs11602189 Imputed A DOM 440 0.8739 0.1947 0.5967 1.28 −0.6923 0.4888 0.3294 0.32727 0.31579 0.336 rs11605163 Imputed A DOM 440 1.075 0.249 0.6597 1.751 0.2893 0.7723 0.4443 0.10341 0.11111 0.09761 rs11615214 Imputed G ADD 437 0.7544 0.1432 0.5697 0.9989 −1.968 0.04908 0.9205 0.39359 0.35526 0.42308 rs11615214 Imputed G GEN 437 8.718 0.01279 0.9205 0.39359 0.35526 0.42308 rs11642394 Imputed C DOM 443 2.011 0.2218 1.302 3.107 3.15 0.00163 0.4471 0.14447 0.17801 0.11905 rs11644943 Imputed A ADD 421 1.464 0.1665 1.056 2.029 2.29 0.02202 0.7836 0.22922 0.26776 0.19958 rs11656608 Imputed T DOM 442 0.5127 0.2187 0.334 0.7871 −3.055 0.00225 0.8632 0.16403 0.11842 0.19841 rs11661309 Imputed A ADD 439 0.8005 0.1812 0.5612 1.142 −1.228 0.2194 0.872 0.18109 0.16138 0.196 rs11661309 Imputed A DOM 439 0.8571 0.2089 0.5691 1.291 −0.7383 0.4603 0.872 0.18109 0.16138 0.196 rs11666131 Imputed A ADD 441 1.074 0.1682 0.772 1.493 0.4219 0.6731 0.2245 0.22676 0.23158 0.22311 rs11743355 Imputed C ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.07341 rs11743355 Imputed C DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.07341 rs11746806 Imputed T ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.07341 rs11746806 Imputed T DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.07341 rs11746959 Imputed T ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.07341 rs11746959 Imputed T DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.07341 rs11749272 Imputed T DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.00954 0.1134 0.34312 0.3089 0.36905 rs11901899 Imputed A DOM 426 1.452 0.1995 0.9821 2.147 1.869 0.06157 0.3322 0.27582 0.30707 0.25207 rs11926319 Imputed G ADD 443 0.9777 0.2632 0.5837 1.638 −0.08556 0.9318 0.4982 0.07675 0.07592 0.07738 rs11926319 Imputed G DOM 443 1.007 0.269 0.5945 1.706 0.02639 0.9789 0.4982 0.07675 0.07592 0.07738 rs11956952 Imputed C DOM 418 0.6491 0.2055 0.4339 0.971 −2.103 0.03544 1 0.24282 0.21858 0.2617 rs12025826 Imputed G DOM 434 1.459 0.2095 0.9676 2.199 1.803 0.07141 1 0.41705 0.4328 0.40524 rs1204522 Imputed C GEN 422 0.09565 0.9533 0.9146 0.34834 0.35326 0.34454 rs1204524 Imputed A GEN 422 0.09565 0.9533 0.9146 0.34834 0.35326 0.34454 rs12153185 Imputed T DOM 441 0.5728 0.2023 0.3853 0.8516 −2.754 0.00589 0.07489 0.35034 0.31316 0.37849 rs12182651 Imputed T ADD 441 0.982 0.2314 0.624 1.545 −0.07863 0.9373 0.07328 0.0907 0.08947 0.09163 rs12182651 Imputed T DOM 441 0.9744 0.2621 0.583 1.629 −0.09893 0.9212 0.07328 0.0907 0.08947 0.09163 rs12193568 Imputed G DOM 361 1.618 0.2464 0.9984 2.623 1.953 0.05077 0.1009 0.14958 0.17296 0.13119 rs12264914 Imputed C DOM 311 0.4742 0.2385 0.2971 0.7568 −3.128 0.00176 1 0.25723 0.20652 0.29769 rs12307767 Imputed C DOM 419 0.6033 0.203 0.4053 0.8981 −2.489 0.0128 0.8317 0.3568 0.31564 0.3875 rs1232298 Imputed G REC 408 1.995 0.3003 1.107 3.593 2.299 0.0215 0.08143 0.34681 0.38483 0.31739 rs12407412 Imputed C ADD 441 1.439 0.1975 0.977 2.119 1.842 0.06547 0.01289 0.12358 0.15 0.10359 rs12407412 Imputed C DOM 441 1.57 0.2354 0.9899 2.491 1.917 0.05525 0.01289 0.12358 0.15 0.10359 rs12420184 Imputed G DOM 438 1.429 0.2168 0.9343 2.185 1.647 0.09966 1 0.14954 0.16931 0.13454 rs12422750 Imputed A DOM 442 0.5888 0.1966 0.4005 0.8656 −2.694 0.00706 0.2411 0.33597 0.29474 0.36706 rs12446951 Imputed A ADD 310 1.549 0.2897 0.8777 2.732 1.51 0.1312 0.7534 0.10161 0.12411 0.08284 rs12446951 Imputed A DOM 310 1.63 0.2998 0.9057 2.933 1.63 0.1032 0.7534 0.10161 0.12411 0.08284 rs12457400 Imputed G DOM 443 0.578 0.2524 0.3525 0.948 −2.172 0.02987 0.8041 0.10497 0.08115 0.12302 rs1247340 Imputed C DOM 441 0.9041 0.2098 0.5993 1.364 −0.4802 0.6311 0.0397 0.20522 0.17895 0.2251 rs1247341 Imputed C DOM 441 0.919 0.2102 0.6087 1.387 −0.4021 0.6876 0.05636 0.20408 0.18063 0.222 rs12521291 Imputed G ADD 435 1.07 0.1477 0.8008 1.429 0.4556 0.6486 0.9172 0.35747 0.36559 0.35141 rs12526849 Imputed T ADD 436 1.012 0.1389 0.7712 1.329 0.08887 0.9292 0.4209 0.39106 0.39362 0.38911 rs12526849 Imputed T GEN 436 1.863 0.394 0.4209 0.39106 0.39362 0.38911 rs12543110 Imputed G DOM 443 1.32 0.1941 0.9026 1.931 1.432 0.1521 0.6236 0.26298 0.27487 0.25397 rs12678600 Imputed A DOM 439 0.7992 0.198 0.5421 1.178 −1.132 0.2575 1 0.31663 0.29894 0.33 rs12719415 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs12831292 Imputed G DOM 436 0.7047 0.2039 0.4725 1.051 −1.716 0.08609 1 0.40367 0.37097 0.428 rs12923993 Imputed C DOM 443 2.011 0.2218 1.302 3.107 3.15 0.00163 0.4471 0.14447 0.17801 0.11905 rs12936964 Imputed T DOM 431 1.123 0.2052 0.7508 1.678 0.5634 0.5732 0.2205 0.38167 0.37097 0.3898 rs12960663 Imputed G ADD 435 0.797 0.1843 0.5553 1.144 −1.231 0.2182 0.8698 0.17701 0.15775 0.19153 rs13038146 Imputed C ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.38743 0.31151 rs13038146 Imputed C GEN 443 6.692 0.03523 0.2479 0.34424 0.38743 0.31151 rs13134222 Imputed A GEN 442 4.511 0.1048 0.6117 0.24887 0.28158 0.22421 rs13172910 Imputed A DOM 417 0.6398 0.2054 0.4278 0.9571 −2.174 0.02974 1 0.2446 0.21858 0.26496 rs13194907 Imputed A ADD 443 1.091 0.2583 0.6574 1.81 0.3362 0.7367 0.279 0.07336 0.07592 0.07143 rs13194907 Imputed A DOM 443 1.162 0.2804 0.6707 2.013 0.5355 0.5923 0.279 0.07336 0.07592 0.07143 rs13195745 Imputed A ADD 443 1.091 0.2583 0.6574 1.81 0.3362 0.7367 0.279 0.07336 0.07592 0.07143 rs13195745 Imputed A DOM 443 1.162 0.2804 0.6707 2.013 0.5355 0.5923 0.279 0.07336 0.07592 0.07143 rs1321432 Imputed A REC 443 0.9755 0.2643 0.5811 1.638 −0.09385 0.9252 0.108 0.38036 0.37696 0.38294 rs1321457 Imputed G REC 435 0.9425 0.2789 0.5456 1.628 −0.2122 0.8319 0.3005 0.36207 0.3617 0.36235 rs13265054 Imputed T DOM 434 0.7541 0.1998 0.5098 1.116 −1.413 0.1577 0.8248 0.31567 0.29412 0.33198 rs13282131 Imputed C GEN 440 6.641 0.03614 0.8464 0.43864 0.47105 0.414 rs13353526 Imputed C DOM 438 0.8239 0.2338 0.521 1.303 −0.8286 0.4073 1 0.12785 0.11842 0.13508 rs1336382 Imputed T DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.36911 0.30754 rs1336383 Imputed T DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.36911 0.30754 rs1336407 Imputed T DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.36911 0.30876 rs1336409 Imputed T DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.36911 0.30876 rs1336596 Imputed A DOM 440 0.9849 0.205 0.659 1.472 −0.07439 0.9407 0.4737 0.36932 0.37632 0.364 rs1343560 Imputed T ADD 437 1.717 0.2225 1.11 2.656 2.43 0.01509 0.1757 0.11899 0.14894 0.09639 rs1343560 Imputed T DOM 437 1.745 0.2319 1.108 2.75 2.402 0.0163 0.1757 0.11899 0.14894 0.09639 rs1361987 Imputed T GEN 443 0.4112 0.8142 0.8328 0.34199 0.34817 0.3373 rs1386153 Imputed T ADD 441 0.8596 0.1501 0.6405 1.154 −1.008 0.3137 0.3322 0.32993 0.31316 0.34263 rs1386153 Imputed T DOM 441 0.8546 0.1947 0.5835 1.252 −0.8069 0.4197 0.3322 0.32993 0.31316 0.34263 rs1394015 Imputed C DOM 372 2.85 1.231 0.2552 31.84 0.8507 0.3949 1 0.00403 0.00633 0.00234 rs1407038 Imputed A REC 443 0.9523 0.2749 0.5556 1.632 −0.178 0.8588 0.1496 0.35892 0.35864 0.35913 rs1407039 Imputed A REC 443 0.9755 0.2643 0.5811 1.638 −0.09385 0.9252 0.108 0.38036 0.37696 0.38294 rs1412802 Imputed T GEN 428 3.851 0.1458 0.7178 0.27804 0.25543 0.29508 rs1414865 Imputed T DOM 442 1.352 0.1976 0.9177 1.991 1.525 0.1272 0.1377 0.33937 0.37173 0.31474 rs1414873 Imputed A DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.36911 0.30876 rs1414876 Imputed C DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.36911 0.30876 rs1418671 Imputed C REC 424 1.095 0.2783 0.6345 1.889 0.3255 0.7448 0.6846 0.39623 0.4011 0.39256 rs1419490 Genotyped T GEN 443 0.3173 0.8533 1 0.33634 0.3377 0.33532 rs1434507 Imputed A ADD 442 1.053 0.1646 0.7624 1.453 0.3112 0.7556 1 0.22624 0.23037 0.22311 rs1434508 Imputed T ADD 442 1.053 0.1646 0.7624 1.453 0.3112 0.7556 1 0.22624 0.23037 0.22311 rs1435205 Imputed A ADD 442 1.021 0.1625 0.7424 1.404 0.1273 0.8987 0.8924 0.22624 0.22895 0.22421 rs1443928 Imputed C REC 435 0.9918 0.2124 0.6541 1.504 −0.03862 0.9692 0.1711 0.57126 0.56806 0.57377 rs1452235 Imputed G GEN 443 5.506 0.06375 0.5227 0.33296 0.36911 0.30556 rs1452236 Imputed G GEN 443 5.506 0.06375 0.5227 0.33296 0.36911 0.30556 rs1452237 Imputed G GEN 443 5.506 0.06375 0.5227 0.33296 0.36911 0.30556 rs1452243 Genotyped T GEN 443 5.995 0.04992 0.6732 0.33973 0.37435 0.31349 rs1463768 Genotyped G REC 443 1.844 0.2673 1.092 3.114 2.29 0.02201 0.5464 0.38262 0.42932 0.34722 rs1463769 Imputed G REC 443 1.844 0.2673 1.092 3.114 2.29 0.02201 0.5464 0.38262 0.42932 0.34722 rs1472435 Imputed A ADD 437 0.5361 0.3365 0.2772 1.037 −1.853 0.0639 0.6259 0.05378 0.03704 0.06653 rs1472435 Imputed A DOM 437 0.5361 0.3365 0.2772 1.037 −1.853 0.0639 0.6259 0.05378 0.03704 0.06653 rs1476714 Imputed A DOM 439 0.5924 0.2025 0.3983 0.8811 −2.585 0.00974 0.1129 0.3451 0.31316 0.36948 rs1495159 Imputed G ADD 429 1.318 0.1505 0.9813 1.77 1.835 0.06656 0.6567 0.31935 0.35135 0.29508 rs1495159 Imputed G GEN 429 9.642 0.00806 0.6567 0.31935 0.35135 0.29508 rs1495375 Imputed A DOM 421 0.7102 0.2081 0.4724 1.068 −1.644 0.1001 0.9197 0.40855 0.37297 0.43644 rs1495376 Imputed T DOM 424 0.774 0.2264 0.4966 1.206 −1.132 0.2577 0.3834 0.48231 0.45652 0.50208 rs1495377 Imputed G DOM 425 0.7814 0.2265 0.5013 1.218 −1.089 0.2762 0.4372 0.48118 0.45652 0.5 rs1495381 Imputed T GEN 442 7.762 0.02063 0.2705 0.38575 0.43421 0.34921 rs1495381 Imputed T REC 442 2.08 0.2834 1.194 3.626 2.584 0.00975 0.2705 0.38575 0.43421 0.34921 rs1498992 Imputed G DOM 428 0.7274 0.1999 0.4916 1.076 −1.592 0.1114 0.4588 0.35047 0.32337 0.3709 rs1499001 Imputed T DOM 437 0.7573 0.1974 0.5144 1.115 −1.409 0.159 0.2889 0.28375 0.26203 0.3 rs1512988 Imputed A DOM 442 0.7185 0.204 0.4817 1.072 −1.621 0.1051 0.6908 0.3948 0.36316 0.41865 rs1512989 Imputed T DOM 442 0.7185 0.204 0.4817 1.072 −1.621 0.1051 0.6908 0.3948 0.36316 0.41865 rs1512991 Imputed T ADD 425 0.7106 0.1399 0.5401 0.9348 −2.442 0.01462 0.3804 0.45647 0.4071 0.4938 rs1512991 Imputed T DOM 425 0.6965 0.2131 0.4587 1.057 −1.698 0.08957 0.3804 0.45647 0.4071 0.4938 rs1516855 Imputed G REC 398 1.236 0.2928 0.6964 2.195 0.7243 0.4689 0.2364 0.36935 0.38571 0.3565 rs1527450 Imputed T ADD 441 1.146 0.1493 0.8556 1.536 0.9151 0.3601 0.6792 0.35714 0.37302 0.34524 rs1527450 Imputed T GEN 441 0.8647 0.649 0.6792 0.35714 0.37302 0.34524 rs1567740 Imputed T DOM 439 0.7204 0.2038 0.4831 1.074 −1.609 0.1076 0.8422 0.39863 0.36579 0.42369 rs1572573 Imputed A ADD 396 1.012 0.2009 0.6826 1.501 0.05984 0.9523 0.00264 0.18813 0.18786 0.18834 rs1572573 Imputed A DOM 396 1.019 0.2128 0.6715 1.546 0.08849 0.9295 0.00264 0.18813 0.18786 0.18834 rs1584003 Imputed C DOM 432 0.6043 0.2157 0.396 0.9221 −2.336 0.0195 0.2438 0.45255 0.42063 0.47737 rs1584005 Imputed C DOM 427 0.6032 0.2163 0.3947 0.9217 −2.337 0.01944 0.2831 0.45082 0.41979 0.475 rs1585771 Imputed G ADD 433 0.9914 0.1575 0.728 1.35 −0.05515 0.956 1 0.26559 0.26486 0.26613 rs1592015 Imputed G DOM 443 1.138 0.2135 0.7487 1.729 0.6045 0.5455 0.2352 0.16817 0.17801 0.16071 rs1594885 Imputed A ADD 440 1.083 0.1634 0.7863 1.492 0.4891 0.6248 0.7887 0.23182 0.23947 0.226 rs1603232 Imputed A DOM 412 0.7502 0.2319 0.4761 1.182 −1.239 0.2152 0.49 0.49029 0.46111 0.51293 rs1614565 Imputed C DOM 439 0.7578 0.2237 0.4888 1.175 −1.24 0.2151 0.6336 0.49089 0.46296 0.512 rs1648200 Imputed G ADD 411 1.299 0.1675 0.9357 1.804 1.563 0.118 1 0.24331 0.26816 0.22414 rs16877387 Imputed C GEN 436 2.224 0.3289 0.5854 0.32569 0.31649 0.33266 rs16877387 Imputed C REC 436 1.186 0.3054 0.6518 2.158 0.5586 0.5764 0.5854 0.32569 0.31649 0.33266 rs16938626 Imputed G DOM 435 0.7689 0.1982 0.5213 1.134 −1.326 0.1849 0.3923 0.26552 0.24866 0.27823 rs1694334 Imputed G ADD 399 1.156 0.1835 0.8068 1.657 0.7904 0.4293 0.5371 0.20426 0.21765 0.19432 rs16998821 Imputed C DOM 443 1.138 0.2135 0.7487 1.729 0.6045 0.5455 0.2352 0.16817 0.17801 0.16071 rs1700400 Imputed T ADD 417 0.9427 0.1613 0.6872 1.293 −0.3659 0.7144 0.1293 0.23141 0.22652 0.23517 rs17007620 Imputed G ADD 408 1.033 0.1717 0.7377 1.446 0.1877 0.8511 1 0.22181 0.22599 0.21861 rs17007620 Imputed G DOM 408 1.127 0.206 0.7523 1.687 0.5784 0.563 1 0.22181 0.22599 0.21861 rs17023290 Imputed C DOM 443 0.8286 0.2404 0.5173 1.327 −0.7821 0.4342 0.8039 0.10722 0.09686 0.11508 rs17047957 Imputed C DOM 439 1.801 0.2129 1.187 2.734 2.765 0.0057 0.6092 0.16856 0.20635 0.14 rs1705237 Imputed A DOM 439 0.7578 0.2237 0.4888 1.175 −1.24 0.2151 0.6336 0.49089 0.46296 0.512 rs1705261 Imputed A GEN 442 7.113 0.02854 0.5499 0.39367 0.43947 0.35913 rs1705261 Imputed A REC 442 2.005 0.2767 1.166 3.449 2.514 0.01192 0.5499 0.39367 0.43947 0.35913 rs17076972 Imputed C ADD 442 1.031 0.1393 0.7845 1.355 0.2183 0.8272 0.5032 0.45814 0.46335 0.45418 rs17076972 Imputed C GEN 442 0.2344 0.8894 0.5032 0.45814 0.46335 0.45418 rs17076972 Imputed C REC 442 0.9776 0.2403 0.6104 1.566 −0.09436 0.9248 0.5032 0.45814 0.46335 0.45418 rs17189710 Imputed T ADD 430 1.382 0.1457 1.039 1.839 2.22 0.02639 0.3369 0.34535 0.38649 0.31429 rs17189710 Imputed T GEN 430 6.752 0.03418 0.3369 0.34535 0.38649 0.31429 rs17196143 Imputed A ADD 443 0.7066 0.186 0.4907 1.017 −1.867 0.06189 1 0.17946 0.15183 0.2004 rs17353809 Imputed G ADD 433 0.9859 0.1679 0.7095 1.37 −0.0846 0.9326 0.569 0.21478 0.21351 0.21573 rs17368986 Imputed A GEN 442 1.393 0.4984 0.6226 0.17534 0.19211 0.1627 rs17369097 Imputed A GEN 443 1.248 0.5357 0.6275 0.17946 0.19634 0.16667 rs17434511 Imputed C GEN 442 1.393 0.4984 0.6226 0.17534 0.19211 0.1627 rs17434589 Imputed C GEN 442 1.393 0.4984 0.6226 0.17534 0.19211 0.1627 rs17434603 Imputed G GEN 442 1.393 0.4984 0.6226 0.17534 0.19211 0.1627 rs17434840 Imputed C GEN 443 1.248 0.5357 0.6275 0.17946 0.19634 0.16667 rs17446418 Imputed G DOM 380 1.044 0.2158 0.6838 1.593 0.1982 0.8429 0.03708 0.32895 0.33537 0.32407 rs17530747 Imputed T DOM 374 1.033 0.2172 0.6751 1.582 0.1511 0.8799 0.0203 0.3369 0.34375 0.33178 rs17604285 Imputed C ADD 443 0.9476 0.2663 0.5622 1.597 −0.2023 0.8397 0.09538 0.07788 0.07592 0.07937 rs17604285 Imputed C DOM 443 0.9476 0.2663 0.5622 1.597 −0.2023 0.8397 0.09538 0.07788 0.07592 0.07937 rs17662322 Imputed T DOM 443 0.7561 0.2081 0.5029 1.137 −1.344 0.179 0.8723 0.18059 0.15969 0.19643 rs17769826 Imputed T ADD 433 0.9859 0.1679 0.7095 1.37 −0.0846 0.9326 0.569 0.21478 0.21351 0.21573 rs17821641 Imputed T ADD 442 1.021 0.1625 0.7424 1.404 0.1273 0.8987 0.8924 0.22624 0.22895 0.22421 rs1782328 Imputed A ADD 426 0.96 0.1915 0.6595 1.397 −0.213 0.8313 0.305 0.17136 0.16758 0.17418 rs1796337 Imputed T DOM 428 0.6991 0.2365 0.4398 1.111 −1.514 0.1301 0.1753 0.51285 0.47581 0.54132 rs1798083 Imputed C DOM 441 0.7428 0.2255 0.4774 1.156 −1.318 0.1874 0.7038 0.5 0.47105 0.52191 rs1798085 Imputed T DOM 439 0.7578 0.2237 0.4888 1.175 −1.24 0.2151 0.6336 0.49089 0.46296 0.512 rs1798086 Imputed T DOM 416 0.7565 0.2341 0.4781 1.197 −1.192 0.2332 0.6948 0.50361 0.47826 0.52371 rs1798089 Imputed C GEN 366 2.947 0.2291 2.13E−06 0.29235 0.31908 0.27336 rs1798089 Imputed C REC 366 2.307 0.5861 0.7314 7.277 1.426 0.1538 2.13E−06 0.29235 0.31908 0.27336 rs1798090 Imputed C GEN 367 3.038 0.2189 1.37E−06 0.29292 0.32026 0.27336 rs1798090 Imputed C REC 367 2.295 0.5861 0.7275 7.238 1.417 0.1564 1.37E−06 0.29292 0.32026 0.27336 rs1832222 Imputed G DOM 443 1.344 0.1965 0.9144 1.975 1.504 0.1325 0.2005 0.33521 0.36911 0.30952 rs1838104 Imputed A ADD 440 0.9138 0.1404 0.694 1.203 −0.6418 0.521 0.5608 0.56591 0.55526 0.574 rs1838104 Imputed A GEN 440 0.6345 0.7281 0.5608 0.56591 0.55526 0.574 rs1868616 Imputed G ADD 437 0.8179 0.1786 0.5764 1.161 −1.126 0.2602 0.8751 0.18764 0.17021 0.2008 rs1874313 Imputed A DOM 443 0.7338 0.2032 0.4927 1.093 −1.523 0.1277 0.6922 0.39503 0.36387 0.41865 rs1884902 Imputed C REC 443 0.9755 0.2643 0.5811 1.638 −0.09385 0.9252 0.108 0.38036 0.37696 0.38294 rs1913201 Imputed G ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.40541 0.48988 rs1913201 Imputed G DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.40541 0.48988 rs1913201 Imputed G GEN 432 6.276 0.04338 0.438 0.4537 0.40541 0.48988 rs1944279 Imputed A ADD 438 1.083 0.1637 0.7858 1.493 0.4879 0.6256 0.7885 0.23174 0.23947 0.22581 rs198461 Imputed C DOM 433 0.5222 0.221 0.3386 0.8052 −2.94 0.00328 0.6307 0.48614 0.43548 0.52429 rs1987179 Imputed T DOM 417 0.5176 0.2237 0.3339 0.8024 −2.944 0.00324 0.8637 0.17266 0.13462 0.20213 rs1990023 Imputed T DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.00954 0.1134 0.34312 0.3089 0.36905 rs2016194 Imputed G DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs2024789 Imputed C ADD 440 0.9942 0.1364 0.7609 1.299 −0.0427 0.9659 0.8491 0.50682 0.50529 0.50797 rs2024789 Imputed C GEN 440 0.0158 0.9921 0.8491 0.50682 0.50529 0.50797 rs2024902 Imputed A ADD 442 1.087 0.2583 0.655 1.803 0.3216 0.7477 0.2797 0.07353 0.07592 0.07171 rs2024902 Imputed A DOM 442 1.157 0.2804 0.6678 2.005 0.52 0.6031 0.2797 0.07353 0.07592 0.07171 rs2025107 Imputed A ADD 442 0.9899 0.2312 0.6292 1.557 −0.04381 0.9651 0.0729 0.0905 0.08947 0.09127 rs2025107 Imputed A DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.08947 0.09127 rs2025108 Imputed T ADD 442 0.9899 0.2312 0.6292 1.557 −0.04381 0.9651 0.0729 0.0905 0.08947 0.09127 rs2025108 Imputed T DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.08947 0.09127 rs2062448 Imputed T ADD 442 0.913 0.2688 0.5391 1.546 −0.3387 0.7348 0.09556 0.07692 0.07368 0.07937 rs2062448 Imputed T DOM 442 0.913 0.2688 0.5391 1.546 −0.3387 0.7348 0.09556 0.07692 0.07368 0.07937 rs2063591 Imputed C ADD 441 0.7255 0.1363 0.5554 0.9478 −2.353 0.01861 0.2947 0.47506 0.42932 0.51 rs2063591 Imputed C DOM 441 0.6936 0.2125 0.4573 1.052 −1.722 0.08515 0.2947 0.47506 0.42932 0.51 rs2065604 Imputed C DOM 443 1.177 0.2597 0.7077 1.959 0.6286 0.5296 0.5598 0.08691 0.09424 0.08135 rs2066238 Imputed T DOM 443 1.138 0.2135 0.7487 1.729 0.6045 0.5455 0.2352 0.16817 0.17801 0.16071 rs2068051 Imputed G ADD 269 0.9214 0.1888 0.6364 1.334 −0.4337 0.6645 0.3082 0.60223 0.59009 0.61076 rs2068051 Imputed G GEN 269 0.367 0.8324 0.3082 0.60223 0.59009 0.61076 rs2077702 Genotyped G GEN 443 8.422 0.01483 0.4324 0.30361 0.3534 0.26587 rs208757 Imputed G ADD 435 1.552 0.175 1.101 2.187 2.512 0.01201 0.6456 0.19425 0.23545 0.1626 rs208757 Imputed G DOM 435 1.858 0.2057 1.241 2.78 3.011 0.0026 0.6456 0.19425 0.23545 0.1626 rs2095586 Imputed A DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.3355 0.33145 0.36649 0.30478 rs2108426 Imputed C DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs2110664 Imputed A DOM 399 1.47 0.2058 0.9818 2.2 1.871 0.06136 1 0.27569 0.30523 0.2533 rs2132242 Imputed A DOM 440 0.6978 0.2022 0.4695 1.037 −1.78 0.07505 1 0.40341 0.36842 0.43 rs2151644 Imputed T DOM 442 1.184 0.2598 0.7118 1.97 0.6512 0.5149 0.7613 0.0871 0.09474 0.08135 rs2157752 Genotyped A GEN 443 0.5489 0.76 0.372 0.30474 0.29843 0.30952 rs2158958 Imputed A DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs2158961 Imputed G DOM 443 0.6399 0.1948 0.4368 0.9373 −2.293 0.02187 0.8242 0.30813 0.2801 0.32937 rs2164099 Imputed G ADD 441 1.075 0.1633 0.7809 1.481 0.4457 0.6558 0.6902 0.23243 0.23947 0.22709 rs2173254 Imputed G GEN 438 0.524 0.7695 0.9154 0.34132 0.35185 0.33333 rs2173254 Imputed G REC 438 1.019 0.3061 0.5595 1.857 0.06273 0.95 0.9154 0.34132 0.35185 0.33333 rs2188079 Imputed C ADD 443 1.028 0.1399 0.7818 1.353 0.2006 0.841 0.563 0.43905 0.44503 0.43452 rs2188079 Imputed C GEN 443 1.2 0.5489 0.563 0.43905 0.44503 0.43452 rs2190304 Imputed G REC 443 1.465 0.2335 0.9272 2.316 1.636 0.1017 1 0.47517 0.47906 0.47222 rs2190597 Imputed T DOM 440 0.6496 0.2095 0.4309 0.9795 −2.059 0.0395 0.1008 0.44318 0.42021 0.46032 rs2190598 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs2190600 Imputed A DOM 440 0.577 0.2025 0.388 0.8581 −2.716 0.00661 0.07522 0.34886 0.31316 0.376 rs2218084 Imputed T GEN 440 5.731 0.05696 0.3138 0.17159 0.17368 0.17 rs2218084 Imputed T REC 440 2.942 0.5498 1.002 8.643 1.963 0.04966 0.3138 0.17159 0.17368 0.17 rs2236290 Genotyped C GEN 441 6.206 0.04491 0.9174 0.35488 0.31675 0.384 rs2243860 Imputed A GEN 354 2.941 0.2298 0.4422 0.4096 0.44737 0.38119 rs2243860 Imputed A REC 354 1.553 0.289 0.8812 2.736 1.522 0.1279 0.4422 0.4096 0.44737 0.38119 rs2246564 Imputed T DOM 443 1.177 0.2597 0.7077 1.959 0.6286 0.5296 0.5598 0.08691 0.09424 0.08135 rs2248236 Imputed C DOM 443 0.5404 0.2044 0.362 0.8067 −3.011 0.0026 0.8852 0.20655 0.17016 0.23413 rs2250340 Imputed T DOM 410 1.184 0.2617 0.709 1.978 0.6458 0.5184 0.7706 0.0939 0.10169 0.08798 rs2257192 Imputed G DOM 443 1.177 0.2597 0.7077 1.959 0.6286 0.5296 0.5598 0.08691 0.09424 0.08135 rs2270584 Imputed A DOM 441 0.6747 0.2026 0.4536 1.004 −1.942 0.05211 0.4848 0.39342 0.35526 0.42231 rs2270586 Imputed A DOM 442 0.6883 0.2018 0.4634 1.022 −1.851 0.06423 0.4864 0.39367 0.35602 0.42231 rs2270589 Imputed A ADD 391 0.6468 0.1498 0.4822 0.8674 −2.909 0.00362 0.7615 0.48082 0.42059 0.52715 rs2270589 Imputed A DOM 391 0.5799 0.2334 0.367 0.9163 −2.335 0.01956 0.7615 0.48082 0.42059 0.52715 rs2270589 Imputed A GEN 391 8.473 0.01446 0.7615 0.48082 0.42059 0.52715 rs2296889 Imputed C DOM 437 0.9005 0.2162 0.5895 1.376 −0.485 0.6277 0.3269 0.17849 0.18182 0.176 rs2301346 Imputed C ADD 357 1.001 0.1711 0.7159 1.4 0.005922 0.9953 0.4976 0.26611 0.26563 0.2665 rs2301346 Imputed C DOM 357 1.026 0.2191 0.6675 1.576 0.1152 0.9083 0.4976 0.26611 0.26563 0.2665 rs2327929 Imputed G REC 441 1.411 0.2475 0.8684 2.291 1.39 0.1645 0.4376 0.42857 0.44764 0.414 rs2357486 Imputed C REC 436 0.8855 0.316 0.4766 1.645 −0.385 0.7003 0.9136 0.32683 0.32181 0.33065 rs2373793 Imputed G DOM 435 1.599 0.2233 1.032 2.477 2.103 0.03546 1 0.14253 0.17368 0.11837 rs2377622 Imputed T GEN 291 8.41 0.01492 1 0.38832 0.33333 0.42857 rs2377622 Imputed T REC 291 0.2954 0.4232 0.1289 0.677 −2.882 0.00396 1 0.38832 0.33333 0.42857 rs2383903 Imputed G DOM 443 0.7568 0.1968 0.5146 1.113 −1.416 0.1569 0.4634 0.26411 0.24607 0.27778 rs2389866 Imputed C DOM 443 0.5404 0.2044 0.362 0.8067 −3.011 0.0026 0.8852 0.20655 0.17016 0.23413 rs2389869 Imputed C DOM 443 0.5404 0.2044 0.362 0.8067 −3.011 0.0026 0.8852 0.20655 0.17016 0.23413 rs2418541 Imputed A DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.00954 0.1134 0.34312 0.3089 0.36905 rs2418542 Imputed A DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.00954 0.1134 0.34312 0.3089 0.36905 rs2418548 Imputed C DOM 442 0.6036 0.2017 0.4065 0.8963 −2.503 0.01231 0.01683 0.35633 0.32199 0.38247 rs2476976 Imputed C DOM 442 1.391 0.1963 0.9466 2.044 1.68 0.09288 0.2817 0.32919 0.36387 0.30279 rs2483639 Imputed A DOM 443 1.177 0.2597 0.7077 1.959 0.6286 0.5296 0.5598 0.08691 0.09424 0.08135 rs2483640 Imputed A DOM 443 1.177 0.2597 0.7077 1.959 0.6286 0.5296 0.5598 0.08691 0.09424 0.08135 rs2544780 Imputed T REC 442 3.054 0.3822 1.444 6.46 2.921 0.00349 0.3055 0.29638 0.33246 0.26892 rs2586458 Imputed T DOM 372 1.439 0.2465 0.8877 2.333 1.477 0.1397 1 0.13172 0.14744 0.12037 rs2593272 Imputed G ADD 443 0.9033 0.1559 0.6654 1.226 −0.6524 0.5141 0.1147 0.23702 0.22775 0.24405 rs2593273 Imputed T ADD 426 0.9769 0.1588 0.7156 1.334 −0.1474 0.8828 0.03674 0.22418 0.2234 0.22479 rs2622499 Imputed G DOM 443 0.5404 0.2044 0.362 0.8067 −3.011 0.0026 0.8852 0.20655 0.17016 0.23413 rs264126 Imputed C DOM 439 0.6379 0.2093 0.4232 0.9615 −2.148 0.03174 0.08131 0.44191 0.41755 0.46016 rs264129 Imputed T DOM 443 0.6399 0.1948 0.4368 0.9373 −2.293 0.02187 0.8242 0.30813 0.2801 0.32937 rs2656822 Imputed T ADD 443 0.9033 0.1559 0.6654 1.226 −0.6524 0.5141 0.1147 0.23702 0.22775 0.24405 rs2656823 Imputed G ADD 443 0.9033 0.1559 0.6654 1.226 −0.6524 0.5141 0.1147 0.23702 0.22775 0.24405 rs2656825 Imputed T ADD 420 0.986 0.1592 0.7217 1.347 −0.08844 0.9295 0.03522 0.225 0.2246 0.22532 rs2764766 Imputed C REC 443 3.069 0.3822 1.451 6.491 2.934 0.00335 0.3053 0.29684 0.33246 0.26984 rs2793101 Imputed T ADD 442 1.081 0.236 0.6809 1.717 0.3309 0.7407 0.7843 0.09615 0.09948 0.09363 rs2793101 Imputed T DOM 442 1.046 0.2497 0.6414 1.707 0.1818 0.8557 0.7843 0.09615 0.09948 0.09363 rs2795871 Imputed A ADD 435 0.5722 0.339 0.2944 1.112 −1.647 0.09966 0.6186 0.05172 0.03763 0.06225 rs2795886 Imputed A ADD 442 0.5272 0.3735 0.2535 1.096 −1.714 0.08652 1 0.04299 0.02895 0.05357 rs2795886 Imputed A DOM 442 0.5272 0.3735 0.2535 1.096 −1.714 0.08652 1 0.04299 0.02895 0.05357 rs2859994 Imputed C GEN 436 0.8834 0.643 0.4109 0.36927 0.37234 0.36694 rs2870464 Imputed G DOM 441 1.969 0.2225 1.273 3.045 3.045 0.00233 0.4419 0.14399 0.17632 0.11952 rs2875528 Imputed T DOM 443 0.8843 0.2352 0.5577 1.402 −0.5227 0.6012 1 0.11851 0.10995 0.125 rs2876227 Imputed C ADD 442 1.389 0.1445 1.046 1.843 2.272 0.02309 0.4631 0.34502 0.38743 0.31275 rs2876227 Imputed C GEN 442 6.593 0.03701 0.4631 0.34502 0.38743 0.31275 rs2882097 Imputed A DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.36911 0.30754 rs2921983 Imputed C ADD 416 0.8945 0.167 0.6448 1.241 −0.6677 0.5043 0.2479 0.21755 0.20718 0.22553 rs2987537 Imputed C DOM 438 1.58 0.2184 1.03 2.424 2.095 0.03621 0.718 0.15753 0.18617 0.136 rs2996416 Imputed C ADD 438 1.725 0.2225 1.115 2.668 2.451 0.01426 0.1759 0.11872 0.14894 0.096 rs2996416 Imputed C DOM 438 1.754 0.2318 1.113 2.762 2.423 0.01539 0.1759 0.11872 0.14894 0.096 rs3015527 Imputed C ADD 398 1.884 0.2353 1.188 2.989 2.693 0.00708 0.3323 0.11558 0.15029 0.08889 rs3015527 Imputed C DOM 398 1.945 0.2451 1.203 3.144 2.714 0.00664 0.3323 0.11558 0.15029 0.08889 rs3015530 Imputed C ADD 438 1.725 0.2225 1.115 2.668 2.451 0.01426 0.1759 0.11872 0.14894 0.096 rs3015530 Imputed C DOM 438 1.754 0.2318 1.113 2.762 2.423 0.01539 0.1759 0.11872 0.14894 0.096 rs3015531 Imputed T ADD 438 1.725 0.2225 1.115 2.668 2.451 0.01426 0.1759 0.11872 0.14894 0.096 rs3015531 Imputed T DOM 438 1.754 0.2318 1.113 2.762 2.423 0.01539 0.1759 0.11872 0.14894 0.096 rs3015535 Imputed C ADD 438 1.725 0.2225 1.115 2.668 2.451 0.01426 0.1759 0.11872 0.14894 0.096 rs3015535 Imputed C DOM 438 1.754 0.2318 1.113 2.762 2.423 0.01539 0.1759 0.11872 0.14894 0.096 rs3019407 Imputed A GEN 439 0.7217 0.6971 1 0.33941 0.35185 0.33 rs3019407 Imputed A REC 439 1.025 0.306 0.5627 1.867 0.08058 0.9358 1 0.33941 0.35185 0.33 rs36071725 Genotyped C GEN 443 0.6419 0.7255 0.5846 0.31828 0.31414 0.32143 rs373983 Imputed G DOM 414 1.954 0.2168 1.277 2.988 3.089 0.00201 0.9193 0.41063 0.45355 0.37662 rs3756154 Imputed C DOM 416 0.5162 0.2209 0.3348 0.7959 −2.993 0.00276 1 0.17668 0.13736 0.20726 rs3793044 Imputed C ADD 443 1.091 0.2583 0.6574 1.81 0.3362 0.7367 0.279 0.07336 0.07592 0.07143 rs3793044 Imputed C DOM 443 1.162 0.2804 0.6707 2.013 0.5355 0.5923 0.279 0.07336 0.07592 0.07143 rs3793053 Imputed C ADD 436 0.995 0.236 0.6266 1.58 −0.02103 0.9832 0.06405 0.0883 0.08777 0.08871 rs3793053 Imputed C DOM 436 0.9919 0.2675 0.5872 1.676 −0.03035 0.9758 0.06405 0.0883 0.08777 0.08871 rs3796246 Imputed G ADD 442 0.9554 0.2625 0.5711 1.598 −0.1737 0.8621 0.5013 0.07805 0.07592 0.07968 rs3796246 Imputed G DOM 442 0.9829 0.2682 0.5811 1.663 −0.06425 0.9488 0.5013 0.07805 0.07592 0.07968 rs3805996 Imputed G ADD 421 1.042 0.2655 0.6195 1.754 0.1561 0.876 0.2844 0.07601 0.07692 0.07531 rs3805996 Imputed G DOM 421 1.106 0.2862 0.631 1.938 0.3512 0.7254 0.2844 0.07601 0.07692 0.07531 rs3806003 Imputed A ADD 443 1.091 0.2583 0.6574 1.81 0.3362 0.7367 0.279 0.07336 0.07592 0.07143 rs3806003 Imputed A DOM 443 1.162 0.2804 0.6707 2.013 0.5355 0.5923 0.279 0.07336 0.07592 0.07143 rs3806004 Imputed T ADD 442 0.9899 0.2312 0.6292 1.557 −0.04381 0.9651 0.0729 0.0905 0.08947 0.09127 rs3806004 Imputed T DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.08947 0.09127 rs3806010 Imputed T ADD 442 0.9899 0.2312 0.6292 1.557 −0.04381 0.9651 0.0729 0.0905 0.08947 0.09127 rs3806010 Imputed T DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.08947 0.09127 rs3806014 Imputed T ADD 430 1.014 0.234 0.6412 1.605 0.06078 0.9515 0.06876 0.0907 0.09016 0.09109 rs3806014 Imputed T DOM 430 1.002 0.2658 0.5954 1.688 0.008889 0.9929 0.06876 0.0907 0.09016 0.09109 rs3806015 Imputed A ADD 426 1.004 0.2345 0.634 1.589 0.01643 0.9869 0.07007 0.09155 0.09066 0.09221 rs3806015 Imputed A DOM 426 0.9945 0.2663 0.5902 1.676 −0.02059 0.9836 0.07007 0.09155 0.09066 0.09221 rs3806018 Imputed A ADD 442 0.9899 0.2312 0.6292 1.557 −0.04381 0.9651 0.0729 0.0905 0.08947 0.09127 rs3806018 Imputed A DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.08947 0.09127 rs3806019 Imputed A ADD 438 0.974 0.2319 0.6182 1.534 −0.1137 0.9095 0.07445 0.09132 0.08995 0.09237 rs3806019 Imputed A DOM 438 0.9676 0.2625 0.5784 1.619 −0.1255 0.9001 0.07445 0.09132 0.08995 0.09237 rs3806024 Imputed T ADD 442 1.029 0.2268 0.6599 1.605 0.1274 0.8986 0.03996 0.09276 0.09424 0.09163 rs3806024 Imputed T DOM 442 1.001 0.2605 0.601 1.669 0.005209 0.9958 0.03996 0.09276 0.09424 0.09163 rs3847825 Imputed G ADD 440 0.7616 0.1432 0.5752 1.008 −1.901 0.05729 1 0.38523 0.34737 0.414 rs3847825 Imputed G GEN 440 6.939 0.03113 1 0.38523 0.34737 0.414 rs3852001 Genotyped C GEN 443 0.9298 0.6282 0.6332 0.18172 0.19634 0.17063 rs3852001 Genotyped C REC 443 1.348 0.5124 0.4937 3.68 0.5827 0.5601 0.6332 0.18172 0.19634 0.17063 rs3852002 Imputed G GEN 443 1.248 0.5357 0.6275 0.17946 0.19634 0.16667 rs3852002 Imputed G REC 443 1.348 0.5124 0.4937 3.68 0.5827 0.5601 0.6275 0.17946 0.19634 0.16667 rs3852003 Imputed A GEN 442 1.289 0.525 0.6277 0.17986 0.19737 0.16667 rs3852003 Imputed A REC 442 1.351 0.5124 0.4947 3.687 0.5864 0.5576 0.6277 0.17986 0.19737 0.16667 rs3942254 Imputed T DOM 420 0.6591 0.2081 0.4383 0.991 −2.004 0.04512 0.1836 0.39167 0.35393 0.41942 rs3945085 Imputed A DOM 441 1.324 0.1969 0.9003 1.948 1.427 0.1537 0.05672 0.34014 0.37435 0.314 rs399485 Imputed A DOM 437 1.648 0.1968 1.12 2.423 2.538 0.01116 0.3195 0.25973 0.29211 0.23482 rs4029119 Imputed G ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.07341 rs4029119 Imputed G DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.07341 rs412791 Imputed C GEN 432 0.1413 0.9318 0.8291 0.33565 0.33957 0.33265 rs4146972 Genotyped T DOM 443 1.832 0.2123 1.208 2.777 2.851 0.00436 0.7362 0.17043 0.20942 0.14087 rs4259369 Imputed C REC 440 0.659 0.2526 0.4017 1.081 −1.651 0.09871 0.3808 0.42727 0.39005 0.45582 rs4273613 Imputed T ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.07341 rs4273613 Imputed T DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.07341 rs4294022 Imputed C DOM 441 1.051 0.1977 0.7133 1.548 0.251 0.8018 0.25 0.2483 0.25132 0.24603 rs4310554 Genotyped C DOM 443 1.561 0.2379 0.9794 2.489 1.872 0.06115 0.9242 0.52032 0.55497 0.49405 rs4315598 Imputed T ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.38743 0.31151 rs4315598 Imputed T GEN 443 6.692 0.03523 0.2479 0.34424 0.38743 0.31151 rs4370878 Imputed G DOM 440 1.312 0.1971 0.8916 1.931 1.378 0.1682 0.1648 0.33523 0.36842 0.31 rs4436200 Imputed C ADD 442 0.543 0.2248 0.3494 0.8436 −2.716 0.0066 0.2274 0.13575 0.10209 0.16135 rs4444612 Imputed G ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.38743 0.31151 rs4444612 Imputed G GEN 443 6.692 0.03523 0.2479 0.34424 0.38743 0.31151 rs4450660 Imputed C DOM 438 1.275 0.1965 0.8675 1.874 1.236 0.2163 0.378 0.25457 0.26316 0.24798 rs4463950 Imputed C DOM 438 0.7997 0.211 0.5288 1.209 −1.06 0.2893 0.18 0.46347 0.44415 0.478 rs4509702 Imputed C DOM 440 1.312 0.1971 0.8916 1.931 1.378 0.1682 0.1648 0.33523 0.36842 0.31 rs4533379 Imputed G ADD 441 1.075 0.1633 0.7809 1.481 0.4457 0.6558 0.6902 0.23243 0.23947 0.22709 rs4569984 Imputed A DOM 426 1.031 0.2026 0.6932 1.534 0.1516 0.8795 0.498 0.23357 0.22973 0.23651 rs4570530 Imputed C DOM 440 1.312 0.1971 0.8916 1.931 1.378 0.1682 0.1648 0.33523 0.36842 0.31 rs4571583 Imputed T DOM 439 1.001 0.1996 0.6767 1.48 0.002892 0.9977 0.3419 0.22665 0.22222 0.23 rs4586678 Imputed A DOM 442 1.235 0.1959 0.8415 1.813 1.079 0.2807 0.4569 0.25679 0.26316 0.25198 rs4615971 Imputed C DOM 440 1.347 0.1965 0.9164 1.98 1.516 0.1296 0.2375 0.33182 0.36579 0.306 rs4629229 Imputed G DOM 443 1.138 0.2135 0.7487 1.729 0.6045 0.5455 0.2352 0.16817 0.17801 0.16071 rs4632512 Imputed T GEN 443 1.248 0.5357 0.6275 0.17946 0.19634 0.16667 rs4641552 Imputed A ADD 437 0.6214 0.279 0.3596 1.074 −1.705 0.08817 1 0.07323 0.05585 0.08635 rs4682527 Imputed C DOM 209 2.955 1.237 0.2613 33.41 0.8755 0.3813 1 0.00718 0.01111 0.0042 rs4688632 Imputed G REC 429 0.6822 0.2335 0.4316 1.078 −1.638 0.1014 0.00063 0.45338 0.41892 0.47951 rs4702720 Imputed A ADD 359 0.757 0.1808 0.5311 1.079 −1.54 0.1236 1 0.24652 0.21935 0.26716 rs4702720 Imputed A DOM 359 0.6462 0.2205 0.4194 0.9956 −1.98 0.04769 1 0.24652 0.21935 0.26716 rs4714484 Imputed A ADD 439 0.8396 0.1992 0.5682 1.241 −0.8775 0.3802 0.3702 0.15718 0.1455 0.166 rs4714484 Imputed A DOM 439 0.8278 0.2185 0.5394 1.27 −0.8651 0.387 0.3702 0.15718 0.1455 0.166 rs4725142 Genotyped G REC 443 1.186 0.2801 0.6847 2.053 0.6082 0.5431 0.1412 0.34537 0.35864 0.33532 rs4725144 Imputed G REC 438 1.136 0.2871 0.647 1.994 0.4432 0.6576 0.1657 0.33904 0.3484 0.332 rs4760785 Imputed A ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.40541 0.48988 rs4760785 Imputed A DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.40541 0.48988 rs4760894 Imputed T ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.40541 0.48988 rs4760894 Imputed T DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.40541 0.48988 rs4760895 Imputed A ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.40541 0.48988 rs4760895 Imputed A DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.40541 0.48988 rs4767184 Imputed C ADD 425 0.7759 0.1466 0.5822 1.034 −1.732 0.08334 0.8408 0.40353 0.3674 0.43033 rs4767184 Imputed C GEN 425 8.173 0.0168 0.8408 0.40353 0.3674 0.43033 rs4773487 Imputed T ADD 436 1.73 0.2227 1.118 2.676 2.461 0.01385 0.1754 0.11927 0.14973 0.09639 rs4780547 Imputed G GEN 442 7.627 0.02207 0.3901 0.26244 0.22775 0.28884 rs4780547 Imputed G REC 442 0.2881 0.4519 0.1188 0.6985 −2.754 0.00588 0.3901 0.26244 0.22775 0.28884 rs483159 Imputed T DOM 386 1.953 0.219 1.271 2.999 3.056 0.00225 0.3957 0.18264 0.22561 0.1509 rs4836502 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs4836507 Imputed C DOM 442 0.5803 0.2019 0.3906 0.862 −2.696 0.00703 0.09482 0.34955 0.31414 0.37649 rs4851531 Imputed T DOM 442 0.6071 0.2055 0.4058 0.9082 −2.428 0.01517 0.2107 0.44231 0.40052 0.4741 rs4879931 Imputed G ADD 438 0.7451 0.1533 0.5517 1.006 −1.92 0.05489 0.5791 0.31279 0.28042 0.33735 rs489441 Imputed G ADD 409 1.224 0.1644 0.8866 1.689 1.228 0.2195 0.6152 0.26773 0.28736 0.25319 rs489441 Imputed G DOM 409 1.384 0.2043 0.9276 2.066 1.592 0.1114 0.6152 0.26773 0.28736 0.25319 rs4976276 Imputed T ADD 440 0.9836 0.1502 0.7328 1.32 −0.1103 0.9121 0.5816 0.31591 0.31316 0.318 rs4977681 Imputed C REC 441 0.9851 0.323 0.523 1.856 −0.04633 0.9631 0.7396 0.31293 0.30105 0.322 rs4986197 Imputed G ADD 440 1.083 0.1634 0.7863 1.492 0.4891 0.6248 0.7887 0.23182 0.23947 0.226 rs4986220 Imputed T ADD 442 1.075 0.1653 0.7775 1.486 0.4371 0.6621 1 0.21946 0.22632 0.21429 rs525462 Imputed A GEN 440 8.36 0.0153 0.4957 0.57045 0.53704 0.59562 rs552006 Imputed G GEN 443 0.4432 0.8012 0.8062 0.26298 0.26178 0.26389 rs5756669 Imputed C DOM 443 1.061 0.217 0.6932 1.623 0.2716 0.7859 0.08691 0.48646 0.50262 0.47421 rs581905 Imputed T DOM 442 2.177 0.2555 1.32 3.593 3.045 0.00232 1 0.09955 0.13089 0.0757 rs6033138 Imputed C ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.38743 0.31151 rs6033138 Imputed C GEN 443 6.692 0.03523 0.2479 0.34424 0.38743 0.31151 rs6040619 Imputed C ADD 439 1.429 0.1436 1.079 1.894 2.487 0.01287 0.3441 0.34852 0.39628 0.31275 rs6040619 Imputed C GEN 439 7.276 0.02631 0.3441 0.34852 0.39628 0.31275 rs6040625 Imputed T ADD 442 1.414 0.1431 1.068 1.871 2.419 0.01557 0.3449 0.34729 0.39267 0.31275 rs6040625 Imputed T GEN 442 6.967 0.0307 0.3449 0.34729 0.39267 0.31275 rs6040630 Imputed A ADD 441 1.401 0.1436 1.058 1.857 2.349 0.01881 0.2464 0.34467 0.38947 0.31076 rs6040630 Imputed A GEN 441 6.767 0.03392 0.2464 0.34467 0.38947 0.31076 rs6040633 Imputed A ADD 442 1.391 0.1433 1.05 1.842 2.302 0.02133 0.2489 0.34502 0.38947 0.31151 rs6040633 Imputed A GEN 442 6.683 0.03539 0.2489 0.34502 0.38947 0.31151 rs6040634 Imputed T ADD 441 1.404 0.1433 1.06 1.859 2.368 0.01791 0.295 0.34694 0.39211 0.31275 rs6040634 Imputed T GEN 441 6.855 0.03246 0.295 0.34694 0.39211 0.31275 rs6040636 Imputed T ADD 443 1.371 0.1435 1.034 1.816 2.196 0.0281 0.2458 0.34312 0.38482 0.31151 rs6040636 Imputed T GEN 443 6.529 0.03821 0.2458 0.34312 0.38482 0.31151 rs6040638 Imputed C ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.38743 0.31151 rs6040638 Imputed C GEN 443 6.692 0.03523 0.2479 0.34424 0.38743 0.31151 rs6040644 Imputed A ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.38743 0.31151 rs6040644 Imputed A GEN 443 6.692 0.03523 0.2479 0.34424 0.38743 0.31151 rs6040667 Imputed T ADD 424 1.422 0.1447 1.071 1.888 2.432 0.01502 0.3997 0.35731 0.40385 0.32231 rs6040667 Imputed T GEN 424 7.201 0.02731 0.3997 0.35731 0.40385 0.32231 rs6040668 Imputed C ADD 440 1.398 0.1448 1.053 1.857 2.314 0.02064 0.5278 0.34659 0.38947 0.314 rs6040668 Imputed C GEN 440 6.796 0.03345 0.5278 0.34659 0.38947 0.314 rs6053005 Imputed C DOM 275 0.4506 0.309 0.2459 0.8257 −2.58 0.00989 0.0865 0.56909 0.53361 0.59615 rs6054405 Imputed A REC 443 0.9755 0.2643 0.5811 1.638 −0.09385 0.9252 0.108 0.38036 0.37696 0.38294 rs6054427 Genotyped G GEN 443 0.8477 0.6545 0.1259 0.36907 0.35602 0.37897 rs6075186 Imputed G DOM 443 1.138 0.2135 0.7487 1.729 0.6045 0.5455 0.2352 0.16817 0.17801 0.16071 rs608278 Imputed A ADD 351 1.166 0.1563 0.8582 1.584 0.9815 0.3263 0.7448 0.43305 0.45364 0.4175 rs6111540 Imputed A ADD 380 0.9692 0.145 0.7295 1.288 −0.2155 0.8294 0.1209 0.45921 0.45181 0.46495 rs6131206 Imputed C ADD 424 1.493 0.1554 1.101 2.025 2.581 0.00986 0.2791 0.28066 0.3288 0.24375 rs6131208 Imputed T ADD 440 1.387 0.1445 1.045 1.841 2.263 0.02364 0.2909 0.34091 0.3836 0.30876 rs6131208 Imputed T GEN 440 6.748 0.03426 0.2909 0.34091 0.3836 0.30876 rs6131919 Imputed G DOM 443 1.138 0.2135 0.7487 1.729 0.6045 0.5455 0.2352 0.16817 0.17801 0.16071 rs6134243 Imputed C ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.38743 0.31151 rs6134243 Imputed C GEN 443 6.692 0.03523 0.2479 0.34424 0.38743 0.31151 rs6136020 Imputed A DOM 441 1.061 0.2134 0.6982 1.612 0.2765 0.7822 0.1646 0.1644 0.17016 0.16 rs613799 Imputed C DOM 420 1.391 0.2013 0.9378 2.065 1.641 0.1008 0.1798 0.32262 0.35912 0.29498 rs644041 Imputed G ADD 402 1.202 0.1659 0.8685 1.664 1.111 0.2667 0.6136 0.27114 0.28947 0.25758 rs644041 Imputed G DOM 402 1.351 0.2068 0.9007 2.026 1.454 0.1459 0.6136 0.27114 0.28947 0.25758 rs6464377 Imputed C DOM 443 1.043 0.2788 0.6037 1.801 0.1498 0.8809 0.4889 0.07223 0.07068 0.07341 rs6474230 Imputed T DOM 443 1.32 0.1941 0.9026 1.931 1.432 0.1521 0.6236 0.26298 0.27487 0.25397 rs6476565 Imputed A DOM 442 1.184 0.2598 0.7118 1.97 0.6512 0.5149 0.7613 0.0871 0.09474 0.08135 rs6511286 Imputed T ADD 442 1.099 0.1394 0.8364 1.444 0.6778 0.4979 0.1082 0.33371 0.34737 0.32341 rs6541829 Genotyped C REC 443 2.003 0.3363 1.036 3.873 2.066 0.03883 0.1994 0.2833 0.2801 0.28571 rs6544721 Imputed G DOM 436 1.236 0.1963 0.8409 1.815 1.077 0.2814 0.454 0.25803 0.26455 0.25304 rs6544728 Imputed T DOM 439 1.333 0.197 0.9058 1.961 1.458 0.1448 0.7087 0.25854 0.26862 0.251 rs6565910 Imputed G DOM 433 1.047 0.1973 0.7112 1.541 0.2331 0.8157 0.7258 0.28753 0.29144 0.28455 rs6581985 Imputed G GEN 408 7.356 0.02528 0.3553 0.31127 0.35714 0.27682 rs6581985 Imputed G REC 408 2.451 0.3667 1.195 5.028 2.445 0.01449 0.3553 0.31127 0.35714 0.27682 rs6685186 Imputed T ADD 426 1.015 0.1482 0.7591 1.357 0.1003 0.9201 0.3984 0.35329 0.35519 0.35185 rs6685186 Imputed T GEN 426 0.5003 0.7787 0.3984 0.35329 0.35519 0.35185 rs670593 Imputed A REC 442 0.3987 0.3133 0.2158 0.7367 −2.935 0.00333 0.7665 0.40045 0.38158 0.41468 rs6722640 Imputed T DOM 441 0.5987 0.207 0.399 0.8983 −2.478 0.01322 0.2486 0.44671 0.40576 0.478 rs6746170 Imputed A DOM 442 1.346 0.196 0.9168 1.977 1.517 0.1293 0.8072 0.26471 0.27749 0.25498 rs6757316 Imputed A GEN 431 3.593 0.1659 0.01072 0.43155 0.45946 0.41057 rs6805139 Imputed G DOM 442 1.417 0.2237 0.9138 2.197 1.557 0.1194 0.00028 0.52941 0.56283 0.50398 rs6808571 Imputed G ADD 440 1.138 0.1981 0.7719 1.678 0.6528 0.5139 1 0.14091 0.15 0.134 rs6816479 Imputed A REC 430 0.7905 0.293 0.4452 1.404 −0.8024 0.4223 0.3984 0.35349 0.32787 0.37247 rs6865976 Imputed C DOM 401 1.085 0.2308 0.69 1.705 0.352 0.7249 0.2704 0.47382 0.48276 0.46696 rs687047 Imputed C ADD 443 0.5642 0.2311 0.3587 0.8876 −2.476 0.01329 0.8186 0.11512 0.08377 0.13889 rs6871041 Imputed G DOM 418 0.6503 0.2006 0.4389 0.9635 −2.145 0.03192 0.6303 0.2823 0.25824 0.30085 rs688358 Imputed A ADD 427 0.5756 0.2319 0.3653 0.9068 −2.382 0.01723 0.8183 0.1171 0.08602 0.14108 rs6908481 Imputed C REC 400 1.391 0.2704 0.8186 2.363 1.22 0.2226 0.7579 0.41875 0.43275 0.4083 rs6917224 Imputed A ADD 441 0.959 0.1367 0.7336 1.254 −0.3058 0.7597 0.1287 0.37642 0.37105 0.38048 rs6917224 Imputed A GEN 441 2.699 0.2593 0.1287 0.37642 0.37105 0.38048 rs6920677 Imputed G DOM 438 0.9579 0.2018 0.645 1.422 −0.2133 0.8311 0.6893 0.39384 0.37831 0.40562 rs6994498 Imputed G DOM 443 1.32 0.1941 0.9026 1.931 1.432 0.1521 0.6236 0.26298 0.27487 0.25397 rs6998772 Imputed T DOM 442 1.182 0.3637 0.5795 2.411 0.4595 0.6459 1 0.04299 0.04712 0.03984 rs7022281 Imputed C ADD 441 0.6915 0.1481 0.5172 0.9244 −2.491 0.01275 0.548 0.38776 0.34392 0.42063 rs7022281 Imputed C GEN 441 9.434 0.00894 0.548 0.38776 0.34392 0.42063 rs7022281 Imputed C REC 441 0.386 0.3115 0.2096 0.7108 −3.056 0.00224 0.548 0.38776 0.34392 0.42063 rs7043983 Imputed T DOM 438 1.147 0.2639 0.6835 1.923 0.5181 0.6044 0.5344 0.08447 0.09043 0.08 rs7077799 Imputed A DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.36911 0.30876 rs7088947 Imputed A ADD 436 0.5704 0.339 0.2936 1.108 −1.656 0.0977 0.6185 0.05161 0.03743 0.06225 rs7089661 Imputed C DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.3355 0.33145 0.36649 0.30478 rs7102072 Imputed A DOM 439 0.9567 0.1978 0.6492 1.41 −0.224 0.8228 0.5412 0.26651 0.25926 0.272 rs710832 Genotyped A REC 443 0.4518 0.4871 0.1739 1.174 −1.631 0.1029 0.4404 0.24492 0.21466 0.26786 rs712531 Imputed A DOM 275 2.784 1.233 0.2485 31.19 0.8305 0.4063 1 0.00545 0.00833 0.00323 rs7129817 Imputed T ADD 441 0.9401 0.1475 0.7041 1.255 −0.4191 0.6751 0.4609 0.3424 0.33598 0.34722 rs7134262 Imputed T GEN 438 5.456 0.06536 1 0.3379 0.37632 0.30847 rs7134262 Imputed T REC 438 1.986 0.3091 1.084 3.641 2.22 0.02641 1 0.3379 0.37632 0.30847 rs7138300 Imputed C ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.40541 0.48988 rs7138300 Imputed C DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.40541 0.48988 rs722927 Imputed G ADD 435 0.8492 0.2939 0.4774 1.511 −0.5561 0.5782 1 0.06207 0.05645 0.06627 rs722927 Imputed G DOM 435 0.874 0.3014 0.4842 1.578 −0.4468 0.655 1 0.06207 0.05645 0.06627 rs726424 Genotyped G ADD 443 0.7827 0.1433 0.5911 1.037 −1.709 0.08742 0.6906 0.38939 0.35602 0.41468 rs726424 Genotyped G GEN 443 7.021 0.02989 0.6906 0.38939 0.35602 0.41468 rs7295817 Imputed C ADD 424 0.727 0.1447 0.5475 0.9655 −2.203 0.02761 1 0.42807 0.38187 0.46281 rs7295817 Imputed C GEN 424 6.629 0.03635 1 0.42807 0.38187 0.46281 rs7295817 Imputed C REC 424 0.4929 0.2774 0.2862 0.849 −2.55 0.01077 1 0.42807 0.38187 0.46281 rs7297372 Imputed A ADD 435 0.7305 0.1423 0.5526 0.9655 −2.207 0.02734 1 0.55977 0.51862 0.59109 rs7297372 Imputed A GEN 435 4.87 0.08761 1 0.55977 0.51862 0.59109 rs7298255 Imputed A ADD 443 0.7433 0.1356 0.5699 0.9696 −2.188 0.02869 0.2143 0.46163 0.41885 0.49405 rs7298255 Imputed A DOM 443 0.74 0.2089 0.4914 1.114 −1.442 0.1493 0.2143 0.46163 0.41885 0.49405 rs7305832 Imputed C GEN 442 5.607 0.06061 1 0.33597 0.37435 0.30677 rs7305832 Imputed C REC 442 2.008 0.3089 1.096 3.678 2.256 0.02404 1 0.33597 0.37435 0.30677 rs737542 Imputed A REC 425 2.077 0.347 1.052 4.1 2.107 0.03514 0.1461 0.27765 0.27596 0.27893 rs742827 Imputed A ADD 437 1.396 0.145 1.051 1.855 2.3 0.02146 0.4608 0.34668 0.38947 0.31377 rs742827 Imputed A GEN 437 6.499 0.03879 0.4608 0.34668 0.38947 0.31377 rs7446891 Imputed G DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs7448641 Imputed C ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.07341 rs7448641 Imputed C DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.07341 rs7460605 Imputed G DOM 412 1.481 0.222 0.9584 2.288 1.769 0.07694 0.1313 0.42961 0.46369 0.40343 rs7468898 Imputed T ADD 426 1.05 0.1419 0.795 1.386 0.3429 0.7317 0.6273 0.47183 0.48077 0.46516 rs7468898 Imputed T GEN 426 1.795 0.4075 0.6273 0.47183 0.48077 0.46516 rs7501186 Imputed A DOM 443 2.011 0.2218 1.302 3.107 3.15 0.00163 0.4471 0.14447 0.17801 0.11905 rs755117 Imputed A DOM 418 0.7161 0.2216 0.4638 1.106 −1.507 0.1319 0.07503 0.16627 0.14641 0.18143 rs7557560 Imputed T GEN 437 3.838 0.1467 0.05904 0.20938 0.20213 0.21486 rs7557560 Imputed T REC 437 1.621 0.4101 0.7258 3.622 1.179 0.2386 0.05904 0.20938 0.20213 0.21486 rs7562462 Imputed T DOM 436 0.6891 0.2101 0.4565 1.04 −1.772 0.07634 0.2049 0.43349 0.40576 0.4551 rs757173 Genotyped G DOM 443 1.033 0.2035 0.6933 1.54 0.1606 0.8724 0.01107 0.37359 0.3822 0.36706 rs7607447 Imputed T REC 410 2.337 0.3138 1.264 4.323 2.706 0.00681 0.3717 0.33049 0.37288 0.29828 rs7639053 Imputed A ADD 443 1.02 0.1656 0.7375 1.411 0.1214 0.9034 0.6744 0.21558 0.21728 0.21429 rs7648163 Imputed C REC 421 0.941 0.3004 0.5223 1.695 −0.2025 0.8396 0.06007 0.32542 0.32222 0.3278 rs7651273 Imputed A GEN 442 1.393 0.4984 0.6226 0.17534 0.19211 0.1627 rs7653190 Imputed C ADD 433 0.9859 0.1679 0.7095 1.37 −0.0846 0.9326 0.569 0.21478 0.21351 0.21573 rs7653685 Genotyped C DOM 443 0.8286 0.2404 0.5173 1.327 −0.7821 0.4342 0.8039 0.10722 0.09686 0.11508 rs7684899 Imputed C DOM 417 0.5176 0.2237 0.3339 0.8024 −2.944 0.00324 0.8637 0.17266 0.13462 0.20213 rs7701604 Imputed G ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.07341 rs7701604 Imputed G DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.07341 rs7703676 Imputed C ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.07341 rs7703676 Imputed C DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.07341 rs7711358 Imputed A DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.00954 0.1134 0.34312 0.3089 0.36905 rs7713251 Imputed C REC 433 1.11 0.3089 0.6058 2.033 0.3374 0.7358 0.08847 0.30485 0.29894 0.30943 rs7737608 Imputed G DOM 399 0.7496 0.2094 0.4973 1.13 −1.376 0.1687 0.912 0.34712 0.32164 0.36623 rs7755903 Imputed A GEN 426 0.886 0.6421 1 0.41197 0.41129 0.4125 rs7762993 Imputed A ADD 431 1.066 0.1948 0.7276 1.561 0.3271 0.7436 0.00187 0.18213 0.18548 0.17959 rs7762993 Imputed A DOM 431 1.079 0.2057 0.7207 1.614 0.3676 0.7132 0.00187 0.18213 0.18548 0.17959 rs7767265 Imputed G DOM 430 1.155 0.1977 0.7839 1.702 0.7283 0.4664 0.0128 0.24419 0.25936 0.23251 rs7769415 Imputed C GEN 433 11.76 0.0028 0.2034 0.34642 0.41176 0.29675 rs7771264 Imputed T DOM 441 1.051 0.1977 0.7133 1.548 0.251 0.8018 0.25 0.2483 0.25132 0.24603 rs7795792 Imputed T REC 440 0.659 0.2526 0.4017 1.081 −1.651 0.09871 0.3808 0.42727 0.39005 0.45582 rs7806481 Imputed G REC 443 1.465 0.2335 0.9272 2.316 1.636 0.1017 1 0.47517 0.47906 0.47222 rs7808536 Imputed G DOM 409 1.374 0.2138 0.904 2.09 1.488 0.1368 0.7448 0.18582 0.2095 0.16739 rs7814819 Imputed G ADD 250 2.296 0.3362 1.188 4.438 2.472 0.01342 1 0.088 0.12736 0.05903 rs7814819 Imputed G DOM 250 2.549 0.3553 1.271 5.115 2.634 0.00844 1 0.088 0.12736 0.05903 rs7815952 Imputed T DOM 442 1.182 0.3637 0.5795 2.411 0.4595 0.6459 1 0.04299 0.04712 0.03984 rs7834090 Imputed T DOM 442 1.182 0.3637 0.5795 2.411 0.4595 0.6459 1 0.04299 0.04712 0.03984 rs7859250 Imputed C DOM 442 1.184 0.2598 0.7118 1.97 0.6512 0.5149 0.7613 0.0871 0.09474 0.08135 rs7863577 Genotyped A ADD 443 1.029 0.2235 0.6639 1.595 0.1275 0.8986 0.01049 0.10835 0.10995 0.10714 rs7863577 Genotyped A DOM 443 0.9475 0.2573 0.5723 1.569 −0.2095 0.8341 0.01049 0.10835 0.10995 0.10714 rs7902140 Imputed C ADD 442 0.9423 0.1886 0.6511 1.364 −0.3154 0.7525 0.2408 0.16968 0.16492 0.17331 rs7921834 Imputed C DOM 440 1.347 0.1965 0.9164 1.98 1.516 0.1296 0.2375 0.33182 0.36579 0.306 rs7939893 Imputed C ADD 441 0.6916 0.1478 0.5177 0.924 −2.495 0.01261 0.3875 0.32653 0.27895 0.36255 rs7939893 Imputed C DOM 441 0.506 0.1982 0.3431 0.7463 −3.437 0.00059 0.3875 0.32653 0.27895 0.36255 rs7955901 Imputed C ADD 440 0.7285 0.1367 0.5573 0.9524 −2.316 0.02054 0.2142 0.46364 0.41842 0.498 rs7955901 Imputed C DOM 440 0.7139 0.2105 0.4726 1.078 −1.601 0.1093 0.2142 0.46364 0.41842 0.498 rs7956274 Imputed T ADD 426 0.7156 0.1398 0.5441 0.9412 −2.394 0.01667 0.3288 0.45423 0.40659 0.48975 rs7956274 Imputed T DOM 426 0.7031 0.2129 0.4633 1.067 −1.655 0.098 0.3288 0.45423 0.40659 0.48975 rs7957932 Imputed G ADD 439 0.7234 0.1368 0.5533 0.9459 −2.366 0.01797 0.3884 0.47039 0.42408 0.50605 rs7957932 Imputed G DOM 439 0.6888 0.212 0.4546 1.044 −1.758 0.07871 0.3884 0.47039 0.42408 0.50605 rs7984294 Imputed A DOM 437 2.115 0.2464 1.305 3.429 3.041 0.00236 0.6016 0.10069 0.13564 0.0743 rs7994286 Imputed A ADD 436 1.764 0.2224 1.141 2.727 2.552 0.0107 0.1747 0.12041 0.15241 0.09639 rs7994286 Imputed A DOM 436 1.796 0.2315 1.141 2.828 2.529 0.01143 0.1747 0.12041 0.15241 0.09639 rs8038229 Genotyped A ADD 443 0.6909 0.1538 0.5111 0.934 −2.404 0.01622 0.8204 0.29684 0.25393 0.32937 rs8038229 Genotyped A DOM 443 0.666 0.1948 0.4546 0.9756 −2.087 0.03693 0.8204 0.29684 0.25393 0.32937 rs8043336 Imputed C GEN 418 0.2115 0.8997 0.4595 0.36124 0.35955 0.3625 rs8043336 Imputed C REC 418 0.9456 0.301 0.5242 1.706 −0.186 0.8525 0.4595 0.36124 0.35955 0.3625 rs8054431 Imputed T DOM 399 1.148 0.2121 0.7573 1.739 0.6492 0.5162 0.01816 0.36842 0.37791 0.36123 rs8066502 Imputed T DOM 442 0.5122 0.2187 0.3337 0.7864 −3.059 0.00222 0.7257 0.16176 0.1178 0.19522 rs8068714 Imputed T DOM 442 0.5127 0.2187 0.334 0.7871 −3.055 0.00225 0.8632 0.16403 0.11842 0.19841 rs892575 Imputed T ADD 442 1.044 0.1635 0.7579 1.439 0.2645 0.7914 1 0.22624 0.23037 0.22311 rs892583 Imputed G ADD 438 1.079 0.1657 0.7796 1.492 0.457 0.6477 1 0.22146 0.22872 0.216 rs915494 Imputed A ADD 422 1.399 0.1473 1.048 1.868 2.281 0.02256 0.1185 0.32227 0.36828 0.28602 rs915494 Imputed A DOM 422 1.486 0.1999 1.004 2.199 1.982 0.0475 0.1185 0.32227 0.36828 0.28602 rs917295 Imputed G DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs922594 Imputed T DOM 443 0.5826 0.1985 0.3948 0.8597 −2.722 0.0065 0.6802 0.36005 0.31675 0.39286 rs9301653 Imputed T ADD 438 1.725 0.2225 1.115 2.668 2.451 0.01426 0.1759 0.11872 0.14894 0.096 rs9301653 Imputed T DOM 438 1.754 0.2318 1.113 2.762 2.423 0.01539 0.1759 0.11872 0.14894 0.096 rs9309988 Imputed G DOM 443 0.8286 0.2404 0.5173 1.327 −0.7821 0.4342 0.8039 0.10722 0.09686 0.11508 rs9309989 Genotyped C DOM 443 0.771 0.2394 0.4822 1.233 −1.086 0.2774 1 0.11174 0.09686 0.12302 rs9310221 Imputed A DOM 393 0.8966 0.2237 0.5784 1.39 −0.4881 0.6255 0.1503 0.42875 0.42604 0.4308 rs9327555 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.00964 0.1134 0.34312 0.31152 0.36706 rs937890 Imputed G DOM 442 0.5127 0.2187 0.334 0.7871 −3.055 0.00225 0.8632 0.16403 0.11842 0.19841 rs9454967 Imputed G ADD 441 0.982 0.2314 0.624 1.545 −0.07863 0.9373 0.07328 0.0907 0.08947 0.09163 rs9454967 Imputed G DOM 441 0.9744 0.2621 0.583 1.629 −0.09893 0.9212 0.07328 0.0907 0.08947 0.09163 rs9471295 Imputed T DOM 443 1.784 0.2155 1.169 2.721 2.686 0.00722 0.7052 0.14786 0.18586 0.11905 rs9477007 Imputed A ADD 436 1.012 0.1389 0.7712 1.329 0.08887 0.9292 0.4209 0.39106 0.39362 0.38911 rs9477007 Imputed A GEN 436 1.863 0.394 0.4209 0.39106 0.39362 0.38911 rs9487279 Imputed T DOM 420 1.094 0.2113 0.7229 1.655 0.4244 0.6713 0.4873 0.42976 0.41892 0.4383 rs949016 Imputed C ADD 441 1.063 0.1656 0.7682 1.47 0.3676 0.7132 1 0.21882 0.22487 0.21429 rs9555973 Imputed G ADD 437 1.732 0.2221 1.12 2.676 2.472 0.01343 0.1748 0.12014 0.15079 0.09677 rs9555973 Imputed G DOM 437 1.761 0.2314 1.119 2.772 2.446 0.01443 0.1748 0.12014 0.15079 0.09677 rs9557510 Imputed G ADD 443 1.342 0.1885 0.9272 1.941 1.559 0.119 0.08093 0.14447 0.16754 0.12698 rs9557510 Imputed G DOM 443 1.316 0.2241 0.848 2.042 1.224 0.2208 0.08093 0.14447 0.16754 0.12698 rs9560584 Imputed T DOM 435 1.792 0.2322 1.137 2.824 2.512 0.01202 0.1752 0.11954 0.15135 0.096 rs9588770 Imputed T DOM 443 1.714 0.2282 1.096 2.68 2.36 0.01827 0.8302 0.12754 0.15707 0.10516 rs9588848 Imputed C ADD 438 1.725 0.2225 1.115 2.668 2.451 0.01426 0.1759 0.11872 0.14894 0.096 rs9588848 Imputed C DOM 438 1.754 0.2318 1.113 2.762 2.423 0.01539 0.1759 0.11872 0.14894 0.096 rs966583 Imputed A ADD 439 0.7596 0.1431 0.5738 1.005 −1.922 0.05464 1 0.40091 0.36579 0.42771 rs966583 Imputed A DOM 439 0.6781 0.203 0.4555 1.01 −1.913 0.0557 1 0.40091 0.36579 0.42771 rs974130 Genotyped A REC 443 0.8861 0.2801 0.5118 1.534 −0.4317 0.6659 0.4714 0.3623 0.34293 0.37698 rs977160 Imputed T ADD 438 0.9972 0.168 0.7174 1.386 −0.0169 0.9865 0.8862 0.21119 0.21011 0.212 rs9812206 Imputed G ADD 442 1.042 0.2668 0.6177 1.758 0.1545 0.8772 0.09556 0.07692 0.07853 0.0757 rs9812206 Imputed G DOM 442 1.042 0.2668 0.6177 1.758 0.1545 0.8772 0.09556 0.07692 0.07853 0.0757 rs9813552 Imputed G ADD 442 1.042 0.2623 0.6235 1.743 0.1586 0.874 0.4984 0.07692 0.07853 0.0757 rs9813552 Imputed G DOM 442 1.077 0.2681 0.6368 1.821 0.2766 0.7821 0.4984 0.07692 0.07853 0.0757 rs9815037 Imputed T ADD 443 1.048 0.2622 0.6267 1.752 0.1778 0.8589 0.4982 0.07675 0.07853 0.0754 rs9815037 Imputed T DOM 443 1.083 0.2681 0.6401 1.831 0.2958 0.7674 0.4982 0.07675 0.07853 0.0754 rs9825349 Imputed A ADD 443 1.048 0.2622 0.6267 1.752 0.1778 0.8589 0.4982 0.07675 0.07853 0.0754 rs9825349 Imputed A DOM 443 1.083 0.2681 0.6401 1.831 0.2958 0.7674 0.4982 0.07675 0.07853 0.0754 rs9834217 Imputed T ADD 443 1.017 0.2611 0.6096 1.696 0.06425 0.9488 0.5011 0.07788 0.07853 0.07738 rs9834217 Imputed T DOM 443 1.049 0.2668 0.6218 1.77 0.179 0.858 0.5011 0.07788 0.07853 0.07738 rs9840460 Imputed T ADD 443 1.017 0.2611 0.6096 1.696 0.06425 0.9488 0.5011 0.07788 0.07853 0.07738 rs9840460 Imputed T DOM 443 1.049 0.2668 0.6218 1.77 0.179 0.858 0.5011 0.07788 0.07853 0.07738 rs9840756 Imputed A ADD 437 0.9995 0.2614 0.5988 1.668 −0.00192 0.9985 0.5026 0.07895 0.07895 0.07895 rs9840756 Imputed A DOM 437 1.031 0.2671 0.6105 1.74 0.1127 0.9103 0.5026 0.07895 0.07895 0.07895 rs9844801 Imputed C DOM 443 0.8286 0.2404 0.5173 1.327 −0.7821 0.4342 0.8039 0.10722 0.09686 0.11508 rs985375 Imputed A GEN 423 0.2263 0.893 0.8976 0.25296 0.25137 0.25417 rs9869187 Imputed C ADD 442 1.037 0.2669 0.6147 1.75 0.1366 0.8914 0.09536 0.07805 0.07895 0.07738 rs9869187 Imputed C DOM 442 1.037 0.2669 0.6147 1.75 0.1366 0.8914 0.09536 0.07805 0.07895 0.07738 rs9872327 Imputed T DOM 443 0.8286 0.2404 0.5173 1.327 −0.7821 0.4342 0.8039 0.10722 0.09686 0.11508 rs9881685 Imputed A ADD 440 1.041 0.2668 0.6172 1.756 0.151 0.88 0.09541 0.07727 0.07895 0.076 rs9881685 Imputed A DOM 440 1.041 0.2668 0.6172 1.756 0.151 0.88 0.09541 0.07727 0.07895 0.076 rs9909499 Imputed C DOM 422 1.716 0.1997 1.161 2.539 2.706 0.00681 0.6472 0.3045 0.33516 0.28125 rs9911847 Imputed G DOM 442 0.5127 0.2187 0.334 0.7871 −3.055 0.00225 0.8632 0.16403 0.11842 0.19841 rs9958823 Imputed A ADD 438 1.083 0.1637 0.7858 1.493 0.4879 0.6256 0.7885 0.23174 0.23947 0.22581 rs9965248 Imputed T ADD 437 1.002 0.1681 0.721 1.394 0.01427 0.9886 0.8864 0.21167 0.21123 0.212 ALLELE PRAVA_(—) PRAVA_(—) PRAVA_(—) SNP rs # SOURCE (A1) MODEL NMISS ATORVA_A1_HZ_COUNT ATORVA_HET_COUNT ATORVA_A2_HZ_COUNT A1_HZ_COUNT HET_COUNT A2_HZ_COUNT rs198460 Genotyped G REC 443 64 86 41 52 135 65 rs603940 Genotyped G REC 443 19 107 65 51 107 94 rs10021016 Genotyped G GEN 443 20 74 97 12 95 145 rs1003148 Imputed C ADD 427 23 96 64 55 115 74 rs1003148 Imputed C GEN 427 23 96 64 55 115 74 rs1003148 Imputed C REC 427 23 96 64 55 115 74 rs10046799 Imputed C ADD 440 61 78 50 82 131 38 rs10046799 Imputed C GEN 440 61 78 50 82 131 38 rs10051148 Imputed C DOM 443 20 67 104 23 120 109 rs10054055 Imputed T DOM 440 23 65 101 29 120 102 rs10067895 Imputed A DOM 440 27 65 98 35 118 97 rs1008705 Imputed C DOM 353 11 76 63 20 66 117 rs10105871 Imputed C DOM 382 22 92 51 27 103 87 rs10116807 Imputed A GEN 436 13 70 107 7 75 164 rs10116807 Imputed A REC 436 13 70 107 7 75 164 rs10121941 Imputed C DOM 443 2 32 157 2 37 213 rs10128638 Genotyped G DOM 443 50 90 51 72 131 49 rs1012924 Imputed G ADD 438 2 52 134 1 46 203 rs1012924 Imputed G DOM 438 2 52 134 1 46 203 rs1016030 Genotyped G ADD 442 27 92 72 31 114 106 rs1016030 Genotyped G GEN 442 27 92 72 31 114 106 rs1017558 Imputed A REC 430 22 76 85 36 112 99 rs10183431 Imputed T DOM 438 11 76 101 20 84 146 rs10195401 Imputed C DOM 440 27 99 64 35 129 86 rs10239416 Imputed A DOM 431 31 93 63 31 114 99 rs1032188 Imputed G GEN 443 10 84 97 30 93 129 rs1032188 Imputed G REC 443 10 84 97 30 93 129 rs10468988 Imputed G ADD 438 9 73 108 13 86 149 rs10478919 Imputed G DOM 443 26 66 99 34 118 100 rs10506623 Imputed C DOM 442 26 86 78 45 121 86 rs10506626 Imputed A DOM 443 26 84 81 46 121 85 rs10509477 Imputed T DOM 443 29 83 79 27 101 124 rs10511071 Imputed C DOM 443 1 35 155 3 52 197 rs10511072 Imputed G DOM 443 1 35 155 3 52 197 rs10511199 Imputed C ADD 442 10 67 113 13 87 152 rs10513283 Imputed G GEN 442 7 59 124 8 66 178 rs10520072 Imputed T DOM 443 27 65 99 33 119 100 rs1065639 Imputed C DOM 209 0 2 88 0 1 118 rs10733846 Imputed G ADD 435 5 45 137 4 78 166 rs10733846 Imputed G DOM 435 5 45 137 4 78 166 rs10737390 Imputed T DOM 418 30 90 59 35 122 82 rs10749293 Imputed G DOM 441 26 84 80 26 96 129 rs10752159 Imputed G DOM 442 7 72 112 14 70 167 rs10753760 Imputed T ADD 423 36 80 69 50 102 86 rs10753760 Imputed T GEN 423 36 80 69 50 102 86 rs10757887 Imputed C DOM 443 19 70 102 23 90 139 rs10758326 Imputed A ADD 440 16 98 76 46 117 87 rs10758326 Imputed A GEN 440 16 98 76 46 117 87 rs10758326 Imputed A REC 440 16 98 76 46 117 87 rs10762236 Genotyped G ADD 443 7 53 131 5 84 163 rs10765769 Imputed C ADD 441 31 94 64 34 118 100 rs10765769 Imputed C GEN 441 31 94 64 34 118 100 rs10784891 Imputed C ADD 422 30 89 65 58 111 69 rs10784891 Imputed C DOM 422 30 89 65 58 111 69 rs10787923 Imputed G DOM 439 26 83 79 26 96 129 rs10787949 Imputed A DOM 442 29 84 78 29 100 122 rs10787951 Imputed G DOM 441 29 83 78 29 100 122 rs10787983 Imputed C DOM 441 29 83 79 27 100 123 rs10788380 Imputed C ADD 438 51 100 37 56 121 73 rs10788380 Imputed C DOM 438 51 100 37 56 121 73 rs10788380 Imputed C GEN 438 51 100 37 56 121 73 rs10814418 Imputed G DOM 442 2 32 156 2 37 213 rs10831417 Imputed A ADD 443 25 93 73 29 116 107 rs10831417 Imputed A GEN 443 25 93 73 29 116 107 rs10831422 Imputed C ADD 441 27 90 72 30 116 106 rs10831422 Imputed C GEN 441 27 90 72 30 116 106 rs10862931 Imputed C GEN 439 32 81 77 23 116 110 rs10865197 Imputed C DOM 438 11 76 101 20 84 146 rs10871302 Imputed A DOM 443 3 62 126 8 44 200 rs10877463 Imputed C DOM 443 21 79 91 34 130 88 rs10877468 Imputed C DOM 442 21 79 91 34 129 88 rs10879240 Imputed C ADD 428 30 92 66 60 111 69 rs10879242 Imputed A DOM 421 26 86 73 45 116 75 rs10879245 Imputed G DOM 421 26 86 73 45 116 75 rs10879249 Imputed T DOM 440 26 87 77 45 121 84 rs10886452 Imputed A DOM 440 30 82 78 26 101 123 rs10886463 Imputed C DOM 442 30 83 78 29 100 122 rs10886465 Imputed A DOM 441 30 83 78 28 100 122 rs10886526 Imputed C DOM 439 28 83 78 26 101 123 rs10902437 Imputed G ADD 393 34 74 55 24 118 88 rs10941126 Imputed G ADD 443 3 22 166 7 23 222 rs10941126 Imputed G DOM 443 3 22 166 7 23 222 rs10947871 Imputed A DOM 391 3 49 122 2 34 181 rs10972978 Imputed G DOM 437 2 32 153 2 36 212 rs10973012 Imputed A DOM 443 2 32 157 2 37 213 rs10974028 Genotyped G ADD 443 5 56 130 5 66 181 rs10974028 Genotyped G DOM 443 5 56 130 5 66 181 rs11021302 Imputed A ADD 441 27 90 72 30 116 106 rs11021302 Imputed A GEN 441 27 90 72 30 116 106 rs11099644 Imputed G REC 430 22 76 85 36 112 99 rs11138315 Imputed G ADD 443 2 35 154 9 63 180 rs11149802 Imputed T DOM 443 3 62 126 8 44 200 rs1116596 Imputed T DOM 443 26 66 99 34 118 100 rs11178531 Imputed A ADD 439 34 92 64 67 117 65 rs11178531 Imputed A DOM 439 34 92 64 67 117 65 rs11178575 Imputed C GEN 441 22 91 78 14 105 131 rs11178575 Imputed C REC 441 22 91 78 14 105 131 rs11178577 Imputed T GEN 439 22 92 76 14 106 129 rs11178577 Imputed T REC 439 22 92 76 14 106 129 rs11178583 Imputed A DOM 443 26 87 78 45 121 86 rs11178589 Imputed T DOM 437 26 87 77 45 120 82 rs11178594 Imputed C DOM 441 26 88 76 45 125 81 rs11178602 Imputed T DOM 439 26 87 76 45 124 81 rs11178648 Imputed T DOM 440 26 83 80 46 120 85 rs11198877 Imputed T DOM 441 30 82 78 26 102 123 rs11198942 Imputed T DOM 443 29 83 79 27 101 124 rs11221075 Imputed A ADD 417 0 27 152 5 58 175 rs11242020 Imputed T DOM 443 26 66 99 34 118 100 rs11242021 Imputed T DOM 443 27 65 99 33 119 100 rs11242022 Imputed T DOM 443 27 65 99 33 119 100 rs11242023 Imputed T DOM 443 27 65 99 33 119 100 rs1149350 Imputed A DOM 443 6 60 125 24 70 158 rs1150143 Imputed G DOM 435 31 83 72 42 109 98 rs11576627 Imputed T ADD 441 7 43 140 6 40 205 rs11576627 Imputed T DOM 441 7 43 140 6 40 205 rs11602189 Imputed A DOM 440 17 86 87 25 118 107 rs11605163 Imputed A DOM 440 4 34 151 2 45 204 rs11615214 Imputed G ADD 437 18 99 73 49 111 87 rs11615214 Imputed G GEN 437 18 99 73 49 111 87 rs11642394 Imputed C DOM 443 3 62 126 8 44 200 rs11644943 Imputed A ADD 421 13 72 98 10 75 153 rs11656608 Imputed T DOM 442 2 41 147 9 82 161 rs11661309 Imputed A ADD 439 3 55 131 12 74 164 rs11661309 Imputed A DOM 439 3 55 131 12 74 164 rs11666131 Imputed A ADD 441 6 76 108 12 88 151 rs11743355 Imputed C ADD 443 3 22 166 7 23 222 rs11743355 Imputed C DOM 443 3 22 166 7 23 222 rs11746806 Imputed T ADD 443 3 22 166 7 23 222 rs11746806 Imputed T DOM 443 3 22 166 7 23 222 rs11746959 Imputed T ADD 443 3 22 166 7 23 222 rs11746959 Imputed T DOM 443 3 22 166 7 23 222 rs11749272 Imputed T DOM 443 26 66 99 34 118 100 rs11901899 Imputed A DOM 426 14 85 85 14 94 134 rs11926319 Imputed G ADD 443 0 29 162 1 37 214 rs11926319 Imputed G DOM 443 0 29 162 1 37 214 rs11956952 Imputed C DOM 418 12 56 115 12 99 124 rs12025826 Imputed G DOM 434 29 103 54 46 109 93 rs1204522 Imputed C GEN 422 24 82 78 28 108 102 rs1204524 Imputed A GEN 422 24 82 78 28 108 102 rs12153185 Imputed T DOM 441 27 65 98 36 118 97 rs12182651 Imputed T ADD 441 3 28 159 4 38 209 rs12182651 Imputed T DOM 441 3 28 159 4 38 209 rs12193568 Imputed G DOM 361 5 45 109 7 39 156 rs12264914 Imputed C DOM 311 8 41 89 12 79 82 rs12307767 Imputed C DOM 419 20 73 86 32 122 86 rs1232298 Imputed G REC 408 33 71 74 24 98 108 rs12407412 Imputed C ADD 441 7 43 140 6 40 205 rs12407412 Imputed C DOM 441 7 43 140 6 40 205 rs12420184 Imputed G DOM 438 4 56 129 5 57 187 rs12422750 Imputed A DOM 442 17 78 95 27 131 94 rs12446951 Imputed A ADD 310 1 33 107 1 26 142 rs12446951 Imputed A DOM 310 1 33 107 1 26 142 rs12457400 Imputed G DOM 443 2 27 162 2 58 192 rs1247340 Imputed C DOM 441 4 60 126 22 69 160 rs1247341 Imputed C DOM 441 4 61 126 21 69 160 rs12521291 Imputed G ADD 435 21 94 71 35 105 109 rs12526849 Imputed T ADD 436 34 80 74 37 119 92 rs12526849 Imputed T GEN 436 34 80 74 37 119 92 rs12543110 Imputed G DOM 443 9 87 95 19 90 143 rs12678600 Imputed A DOM 439 18 77 94 26 113 111 rs12719415 Imputed T DOM 443 27 65 99 33 119 100 rs12831292 Imputed G DOM 436 26 86 74 45 124 81 rs12923993 Imputed C DOM 443 3 62 126 8 44 200 rs12936964 Imputed T DOM 431 23 92 71 46 99 100 rs12960663 Imputed G ADD 435 3 53 131 11 73 164 rs13038146 Imputed C ADD 443 34 80 77 24 109 119 rs13038146 Imputed C GEN 443 34 80 77 24 109 119 rs13134222 Imputed A GEN 442 13 81 96 12 89 151 rs13172910 Imputed A DOM 417 12 56 115 13 98 123 rs13194907 Imputed A ADD 443 1 27 163 3 30 219 rs13194907 Imputed A DOM 443 1 27 163 3 30 219 rs13195745 Imputed A ADD 443 1 27 163 3 30 219 rs13195745 Imputed A DOM 443 1 27 163 3 30 219 rs1321432 Imputed A REC 443 31 82 78 41 111 100 rs1321457 Imputed G REC 435 26 84 78 36 107 104 rs13265054 Imputed T DOM 434 17 76 94 25 114 108 rs13282131 Imputed C GEN 440 47 85 58 39 129 82 rs13353526 Imputed C DOM 438 2 41 147 5 57 186 rs1336382 Imputed T DOM 443 29 83 79 27 101 124 rs1336383 Imputed T DOM 443 29 83 79 27 101 124 rs1336407 Imputed T DOM 442 29 83 79 27 101 123 rs1336409 Imputed T DOM 442 29 83 79 27 101 123 rs1336596 Imputed A DOM 440 28 87 75 28 126 96 rs1343560 Imputed T ADD 437 2 52 134 1 46 202 rs1343560 Imputed T DOM 437 2 52 134 1 46 202 rs1361987 Imputed T GEN 443 25 83 83 28 114 110 rs1386153 Imputed T ADD 441 16 87 87 27 118 106 rs1386153 Imputed T DOM 441 16 87 87 27 118 106 rs1394015 Imputed C DOM 372 0 2 156 0 1 213 rs1407038 Imputed A REC 443 27 83 81 37 107 108 rs1407039 Imputed A REC 443 31 82 78 41 111 100 rs1412802 Imputed T GEN 428 8 78 98 23 98 123 rs1414865 Imputed T DOM 442 29 84 78 29 100 122 rs1414873 Imputed A DOM 442 29 83 79 27 101 123 rs1414876 Imputed C DOM 442 29 83 79 27 101 123 rs1418671 Imputed C REC 424 29 88 65 35 120 87 rs1419490 Genotyped T GEN 443 23 83 85 27 115 110 rs1434507 Imputed A ADD 442 9 70 112 13 86 152 rs1434508 Imputed T ADD 442 9 70 112 13 86 152 rs1435205 Imputed A ADD 442 10 67 113 13 87 152 rs1443928 Imputed C REC 435 65 87 39 84 112 48 rs1452235 Imputed G GEN 443 30 81 80 22 110 120 rs1452236 Imputed G GEN 443 30 81 80 22 110 120 rs1452237 Imputed G GEN 443 30 81 80 22 110 120 rs1452243 Genotyped T GEN 443 31 81 79 22 114 116 rs1463768 Genotyped G REC 443 38 88 65 30 115 107 rs1463769 Imputed G REC 443 38 88 65 30 115 107 rs1472435 Imputed A ADD 437 0 14 175 0 33 215 rs1472435 Imputed A DOM 437 0 14 175 0 33 215 rs1476714 Imputed A DOM 439 27 65 98 33 118 98 rs1495159 Imputed G ADD 429 18 94 73 28 88 128 rs1495159 Imputed G GEN 429 18 94 73 28 88 128 rs1495375 Imputed A DOM 421 26 86 73 45 116 75 rs1495376 Imputed T DOM 424 36 96 52 58 125 57 rs1495377 Imputed G DOM 425 36 96 52 58 125 58 rs1495381 Imputed T GEN 442 35 95 60 25 126 101 rs1495381 Imputed T REC 442 35 95 60 25 126 101 rs1498992 Imputed G DOM 428 22 75 87 34 113 97 rs1499001 Imputed T DOM 437 16 66 105 24 102 124 rs1512988 Imputed A DOM 442 26 86 78 45 121 86 rs1512989 Imputed T DOM 442 26 86 78 45 121 86 rs1512991 Imputed T ADD 425 30 89 64 63 113 66 rs1512991 Imputed T DOM 425 30 89 64 63 113 66 rs1516855 Imputed G REC 398 29 77 69 31 97 95 rs1527450 Imputed T ADD 441 25 91 73 29 116 107 rs1527450 Imputed T GEN 441 25 91 73 29 116 107 rs1567740 Imputed T DOM 439 26 87 77 45 121 83 rs1572573 Imputed A ADD 396 2 61 110 3 78 142 rs1572573 Imputed A DOM 396 2 61 110 3 78 142 rs1584003 Imputed C DOM 432 35 89 65 47 138 58 rs1584005 Imputed C DOM 427 35 87 65 46 136 58 rs1585771 Imputed G ADD 433 13 72 100 17 98 133 rs1592015 Imputed G DOM 443 8 52 131 8 65 179 rs1594885 Imputed A ADD 440 9 73 108 13 87 150 rs1603232 Imputed A DOM 412 36 94 50 59 120 53 rs1614565 Imputed C DOM 439 39 97 53 64 128 58 rs1648200 Imputed G ADD 411 14 68 97 10 84 138 rs16877387 Imputed C GEN 436 23 73 92 26 113 109 rs16877387 Imputed C REC 436 23 73 92 26 113 109 rs16938626 Imputed G DOM 435 15 63 109 19 100 129 rs1694334 Imputed G ADD 399 7 60 103 7 75 147 rs16998821 Imputed C DOM 443 8 52 131 8 65 179 rs1700400 Imputed T ADD 417 12 58 111 16 79 141 rs17007620 Imputed G ADD 408 7 66 104 13 75 143 rs17007620 Imputed G DOM 408 7 66 104 13 75 143 rs17023290 Imputed C DOM 443 1 35 155 3 52 197 rs17047957 Imputed C DOM 439 7 64 118 7 56 187 rs1705237 Imputed A DOM 439 39 97 53 64 128 58 rs1705261 Imputed A GEN 442 37 93 60 28 125 99 rs1705261 Imputed A REC 442 37 93 60 28 125 99 rs17076972 Imputed C ADD 442 38 101 52 51 126 74 rs17076972 Imputed C GEN 442 38 101 52 51 126 74 rs17076972 Imputed C REC 442 38 101 52 51 126 74 rs17189710 Imputed T ADD 430 33 77 75 23 108 114 rs17189710 Imputed T GEN 430 33 77 75 23 108 114 rs17196143 Imputed A ADD 443 2 54 135 12 77 163 rs17353809 Imputed G ADD 433 10 59 116 12 83 153 rs17368986 Imputed A GEN 442 7 59 124 8 66 178 rs17369097 Imputed A GEN 443 8 59 124 8 68 176 rs17434511 Imputed C GEN 442 7 59 124 8 66 178 rs17434589 Imputed C GEN 442 7 59 124 8 66 178 rs17434603 Imputed G GEN 442 7 59 124 8 66 178 rs17434840 Imputed C GEN 443 8 59 124 8 68 176 rs17446418 Imputed G DOM 380 14 82 68 18 104 94 rs17530747 Imputed T DOM 374 14 82 64 18 106 90 rs17604285 Imputed C ADD 443 0 29 162 0 40 212 rs17604285 Imputed C DOM 443 0 29 162 0 40 212 rs17662322 Imputed T DOM 443 5 51 135 10 79 163 rs17769826 Imputed T ADD 433 10 59 116 12 83 153 rs17821641 Imputed T ADD 442 10 67 113 13 87 152 rs1782328 Imputed A ADD 426 5 51 126 4 77 163 rs1796337 Imputed T DOM 428 38 101 47 67 128 47 rs1798083 Imputed C DOM 441 41 97 52 67 128 56 rs1798085 Imputed T DOM 439 39 97 53 64 128 58 rs1798086 Imputed T DOM 416 41 94 49 62 119 51 rs1798089 Imputed C GEN 366 8 81 63 5 107 102 rs1798089 Imputed C REC 366 8 81 63 5 107 102 rs1798090 Imputed C GEN 367 8 82 63 5 107 102 rs1798090 Imputed C REC 367 8 82 63 5 107 102 rs1832222 Imputed G DOM 443 29 83 79 27 102 123 rs1838104 Imputed A ADD 440 61 89 40 83 121 46 rs1838104 Imputed A GEN 440 61 89 40 83 121 46 rs1868616 Imputed G ADD 437 6 52 130 10 80 159 rs1874313 Imputed A DOM 443 26 87 78 45 121 86 rs1884902 Imputed C REC 443 31 82 78 41 111 100 rs1913201 Imputed G ADD 432 30 90 65 63 116 68 rs1913201 Imputed G DOM 432 30 90 65 63 116 68 rs1913201 Imputed G GEN 432 30 90 65 63 116 68 rs1944279 Imputed A ADD 438 9 73 108 13 86 149 rs198461 Imputed C DOM 433 40 82 64 65 129 53 rs1987179 Imputed T DOM 417 6 37 139 7 81 147 rs1990023 Imputed T DOM 443 26 66 99 34 118 100 rs2016194 Imputed G DOM 443 27 65 99 33 119 100 rs2024789 Imputed C ADD 440 49 93 47 65 125 61 rs2024789 Imputed C GEN 440 49 93 47 65 125 61 rs2024902 Imputed A ADD 442 1 27 163 3 30 218 rs2024902 Imputed A DOM 442 1 27 163 3 30 218 rs2025107 Imputed A ADD 442 3 28 159 4 38 210 rs2025107 Imputed A DOM 442 3 28 159 4 38 210 rs2025108 Imputed T ADD 442 3 28 159 4 38 210 rs2025108 Imputed T DOM 442 3 28 159 4 38 210 rs2062448 Imputed T ADD 442 0 28 162 0 40 212 rs2062448 Imputed T DOM 442 0 28 162 0 40 212 rs2063591 Imputed C ADD 441 36 92 63 69 117 64 rs2063591 Imputed C DOM 441 36 92 63 69 117 64 rs2065604 Imputed C DOM 443 2 32 157 2 37 213 rs2066238 Imputed T DOM 443 8 52 131 8 65 179 rs2068051 Imputed G ADD 269 36 59 16 57 79 22 rs2068051 Imputed G GEN 269 36 59 16 57 79 22 rs2077702 Genotyped G GEN 443 22 91 78 15 104 133 rs208757 Imputed G ADD 435 8 73 108 10 60 176 rs208757 Imputed G DOM 435 8 73 108 10 60 176 rs2095586 Imputed A DOM 442 28 84 79 25 103 123 rs2108426 Imputed C DOM 443 27 65 99 33 119 100 rs2110664 Imputed A DOM 399 14 77 81 16 83 128 rs2132242 Imputed A DOM 440 26 88 76 45 125 80 rs2151644 Imputed T DOM 442 2 32 156 2 37 213 rs2157752 Genotyped A GEN 443 20 74 97 25 106 121 rs2158958 Imputed A DOM 443 27 65 99 33 119 100 rs2158961 Imputed G DOM 443 20 67 104 23 120 109 rs2164099 Imputed G ADD 441 9 73 108 13 88 150 rs2173254 Imputed G GEN 438 22 89 78 28 110 111 rs2173254 Imputed G REC 438 22 89 78 28 110 111 rs2188079 Imputed C ADD 443 39 92 60 43 133 76 rs2188079 Imputed C GEN 443 39 92 60 43 133 76 rs2190304 Imputed G REC 443 50 83 58 50 138 64 rs2190597 Imputed T DOM 440 42 74 72 53 126 73 rs2190598 Imputed T DOM 443 27 65 99 33 119 100 rs2190600 Imputed A DOM 440 27 65 98 35 118 97 rs2218084 Imputed T GEN 440 11 44 135 5 75 170 rs2218084 Imputed T REC 440 11 44 135 5 75 170 rs2236290 Genotyped C GEN 441 16 89 86 40 112 98 rs2243860 Imputed A GEN 354 33 70 49 30 94 78 rs2243860 Imputed A REC 354 33 70 49 30 94 78 rs2246564 Imputed T DOM 443 2 32 157 2 37 213 rs2248236 Imputed C DOM 443 9 47 135 9 100 143 rs2250340 Imputed T DOM 410 2 32 143 2 37 194 rs2257192 Imputed G DOM 443 2 32 157 2 37 213 rs2270584 Imputed A DOM 441 26 83 81 46 120 85 rs2270586 Imputed A DOM 442 26 84 81 46 120 85 rs2270589 Imputed A ADD 391 30 83 57 62 109 50 rs2270589 Imputed A DOM 391 30 83 57 62 109 50 rs2270589 Imputed A GEN 391 30 83 57 62 109 50 rs2296889 Imputed C DOM 437 10 48 129 7 74 169 rs2301346 Imputed C ADD 357 12 61 87 16 73 108 rs2301346 Imputed C DOM 357 12 61 87 16 73 108 rs2327929 Imputed G REC 441 42 87 62 43 121 86 rs2357486 Imputed C REC 436 19 83 86 28 108 112 rs2373793 Imputed G DOM 435 6 54 130 3 52 190 rs2377622 Imputed T GEN 291 10 62 51 34 76 58 rs2377622 Imputed T REC 291 10 62 51 34 76 58 rs2383903 Imputed G DOM 443 15 64 112 19 102 131 rs2389866 Imputed C DOM 443 9 47 135 9 100 143 rs2389869 Imputed C DOM 443 9 47 135 9 100 143 rs2418541 Imputed A DOM 443 26 66 99 34 118 100 rs2418542 Imputed A DOM 443 26 66 99 34 118 100 rs2418548 Imputed C DOM 442 29 65 97 39 114 98 rs2476976 Imputed C DOM 442 27 85 79 26 100 125 rs2483639 Imputed A DOM 443 2 32 157 2 37 213 rs2483640 Imputed A DOM 443 2 32 157 2 37 213 rs2544780 Imputed T REC 442 23 81 87 11 113 127 rs2586458 Imputed T DOM 372 2 42 112 4 44 168 rs2593272 Imputed G ADD 443 12 63 116 19 85 148 rs2593273 Imputed T ADD 426 12 60 116 17 73 148 rs2622499 Imputed G DOM 443 9 47 135 9 100 143 rs264126 Imputed C DOM 439 42 73 73 53 125 73 rs264129 Imputed T DOM 443 20 67 104 23 120 109 rs2656822 Imputed T ADD 443 12 63 116 19 85 148 rs2656823 Imputed G ADD 443 12 63 116 19 85 148 rs2656825 Imputed T ADD 420 12 60 115 17 71 145 rs2764766 Imputed C REC 443 23 81 87 11 114 127 rs2793101 Imputed T ADD 442 2 34 155 1 45 205 rs2793101 Imputed T DOM 442 2 34 155 1 45 205 rs2795871 Imputed A ADD 435 0 14 172 0 31 218 rs2795886 Imputed A ADD 442 0 11 179 0 27 225 rs2795886 Imputed A DOM 442 0 11 179 0 27 225 rs2859994 Imputed C GEN 436 22 96 70 33 116 99 rs2870464 Imputed G DOM 441 3 61 126 8 44 199 rs2875528 Imputed T DOM 443 1 40 150 5 53 194 rs2876227 Imputed C ADD 442 33 82 76 23 111 117 rs2876227 Imputed C GEN 442 33 82 76 23 111 117 rs2882097 Imputed A DOM 443 29 83 79 27 101 124 rs2921983 Imputed C ADD 416 9 57 115 15 76 144 rs2987537 Imputed C DOM 438 6 58 124 6 56 188 rs2996416 Imputed C ADD 438 2 52 134 1 46 203 rs2996416 Imputed C DOM 438 2 52 134 1 46 203 rs3015527 Imputed C ADD 398 2 48 123 1 38 186 rs3015527 Imputed C DOM 398 2 48 123 1 38 186 rs3015530 Imputed C ADD 438 2 52 134 1 46 203 rs3015530 Imputed C DOM 438 2 52 134 1 46 203 rs3015531 Imputed T ADD 438 2 52 134 1 46 203 rs3015531 Imputed T DOM 438 2 52 134 1 46 203 rs3015535 Imputed C ADD 438 2 52 134 1 46 203 rs3015535 Imputed C DOM 438 2 52 134 1 46 203 rs3019407 Imputed A GEN 439 22 89 78 28 109 113 rs3019407 Imputed A REC 439 22 89 78 28 109 113 rs36071725 Genotyped C GEN 443 16 88 87 26 110 116 rs373983 Imputed G DOM 414 31 104 48 38 98 95 rs3756154 Imputed C DOM 416 6 38 138 7 83 144 rs3793044 Imputed C ADD 443 1 27 163 3 30 219 rs3793044 Imputed C DOM 443 1 27 163 3 30 219 rs3793053 Imputed C ADD 436 3 27 158 4 36 208 rs3793053 Imputed C DOM 436 3 27 158 4 36 208 rs3796246 Imputed G ADD 442 0 29 162 1 38 212 rs3796246 Imputed G DOM 442 0 29 162 1 38 212 rs3805996 Imputed G ADD 421 1 26 155 3 30 206 rs3805996 Imputed G DOM 421 1 26 155 3 30 206 rs3806003 Imputed A ADD 443 1 27 163 3 30 219 rs3806003 Imputed A DOM 443 1 27 163 3 30 219 rs3806004 Imputed T ADD 442 3 28 159 4 38 210 rs3806004 Imputed T DOM 442 3 28 159 4 38 210 rs3806010 Imputed T ADD 442 3 28 159 4 38 210 rs3806010 Imputed T DOM 442 3 28 159 4 38 210 rs3806014 Imputed T ADD 430 3 27 153 4 37 206 rs3806014 Imputed T DOM 430 3 27 153 4 37 206 rs3806015 Imputed A ADD 426 3 27 152 4 37 203 rs3806015 Imputed A DOM 426 3 27 152 4 37 203 rs3806018 Imputed A ADD 442 3 28 159 4 38 210 rs3806018 Imputed A DOM 442 3 28 159 4 38 210 rs3806019 Imputed A ADD 438 3 28 158 4 38 207 rs3806019 Imputed A DOM 438 3 28 158 4 38 207 rs3806024 Imputed T ADD 442 4 28 159 4 38 209 rs3806024 Imputed T DOM 442 4 28 159 4 38 209 rs3847825 Imputed G ADD 440 18 96 76 47 113 90 rs3847825 Imputed G GEN 440 18 96 76 47 113 90 rs3852001 Genotyped C GEN 443 8 59 124 8 70 174 rs3852001 Genotyped C REC 443 8 59 124 8 70 174 rs3852002 Imputed G GEN 443 8 59 124 8 68 176 rs3852002 Imputed G REC 443 8 59 124 8 68 176 rs3852003 Imputed A GEN 442 8 59 123 8 68 176 rs3852003 Imputed A REC 442 8 59 123 8 68 176 rs3942254 Imputed T DOM 420 26 74 78 45 113 84 rs3945085 Imputed A DOM 441 31 81 79 29 99 122 rs399485 Imputed A DOM 437 10 91 89 15 86 146 rs4029119 Imputed G ADD 443 3 22 166 7 23 222 rs4029119 Imputed G DOM 443 3 22 166 7 23 222 rs412791 Imputed C GEN 432 23 81 83 27 109 109 rs4146972 Genotyped T DOM 443 7 66 118 7 57 188 rs4259369 Imputed C REC 440 30 89 72 55 117 77 rs4273613 Imputed T ADD 443 3 22 166 7 23 222 rs4273613 Imputed T DOM 443 3 22 166 7 23 222 rs4294022 Imputed C DOM 441 14 67 108 18 88 146 rs4310554 Genotyped C DOM 443 56 100 35 63 123 66 rs4315598 Imputed T ADD 443 34 80 77 24 109 119 rs4315598 Imputed T GEN 443 34 80 77 24 109 119 rs4370878 Imputed G DOM 440 29 82 79 27 101 122 rs4436200 Imputed C ADD 442 2 35 154 9 63 179 rs4444612 Imputed G ADD 443 34 80 77 24 109 119 rs4444612 Imputed G GEN 443 34 80 77 24 109 119 rs4450660 Imputed C DOM 438 11 78 101 21 81 146 rs4463950 Imputed C DOM 438 41 85 62 60 119 71 rs4509702 Imputed C DOM 440 29 82 79 27 101 122 rs4533379 Imputed G ADD 441 9 73 108 13 88 150 rs4569984 Imputed A DOM 426 10 65 110 16 82 143 rs4570530 Imputed C DOM 440 29 82 79 27 101 122 rs4571583 Imputed T DOM 439 10 64 115 16 83 151 rs4586678 Imputed A DOM 442 11 78 101 21 85 146 rs4615971 Imputed C DOM 440 28 83 79 26 101 123 rs4629229 Imputed G DOM 443 8 52 131 8 65 179 rs4632512 Imputed T GEN 443 8 59 124 8 68 176 rs4641552 Imputed A ADD 437 0 21 167 2 39 208 rs4682527 Imputed C DOM 209 0 2 88 0 1 118 rs4688632 Imputed G REC 429 38 79 68 68 98 78 rs4702720 Imputed A ADD 359 10 48 97 12 85 107 rs4702720 Imputed A DOM 359 10 48 97 12 85 107 rs4714484 Imputed A ADD 439 3 49 137 5 73 172 rs4714484 Imputed A DOM 439 3 49 137 5 73 172 rs4725142 Genotyped G REC 443 28 81 82 32 105 115 rs4725144 Imputed G REC 438 26 79 83 31 104 115 rs4760785 Imputed A ADD 432 30 90 65 63 116 68 rs4760785 Imputed A DOM 432 30 90 65 63 116 68 rs4760894 Imputed T ADD 432 30 90 65 63 116 68 rs4760894 Imputed T DOM 432 30 90 65 63 116 68 rs4760895 Imputed A ADD 432 30 90 65 63 116 68 rs4760895 Imputed A DOM 432 30 90 65 63 116 68 rs4767184 Imputed C ADD 425 18 97 66 50 110 84 rs4767184 Imputed C GEN 425 18 97 66 50 110 84 rs4773487 Imputed T ADD 436 2 52 133 1 46 202 rs4780547 Imputed G GEN 442 7 73 111 27 91 133 rs4780547 Imputed G REC 442 7 73 111 27 91 133 rs483159 Imputed T DOM 386 4 66 94 6 55 161 rs4836502 Imputed T DOM 443 27 65 99 33 119 100 rs4836507 Imputed C DOM 442 27 66 98 35 119 97 rs4851531 Imputed T DOM 442 36 81 74 57 124 70 rs4879931 Imputed G ADD 438 10 86 93 30 108 111 rs489441 Imputed G ADD 409 11 78 85 16 87 132 rs489441 Imputed G DOM 409 11 78 85 16 87 132 rs4976276 Imputed T ADD 440 17 85 88 24 111 115 rs4977681 Imputed C REC 441 19 77 95 26 109 115 rs4986197 Imputed G ADD 440 9 73 108 13 87 150 rs4986220 Imputed T ADD 442 9 68 113 12 84 156 rs525462 Imputed A GEN 440 62 79 48 85 129 37 rs552006 Imputed G GEN 443 11 78 102 18 97 137 rs5756669 Imputed C DOM 443 54 84 53 60 119 73 rs581905 Imputed T DOM 442 2 46 143 2 34 215 rs6033138 Imputed C ADD 443 34 80 77 24 109 119 rs6033138 Imputed C GEN 443 34 80 77 24 109 119 rs6040619 Imputed C ADD 439 34 81 73 24 109 118 rs6040619 Imputed C GEN 439 34 81 73 24 109 118 rs6040625 Imputed T ADD 442 34 82 75 24 109 118 rs6040625 Imputed T GEN 442 34 82 75 24 109 118 rs6040630 Imputed A ADD 441 34 80 76 24 108 119 rs6040630 Imputed A GEN 441 34 80 76 24 108 119 rs6040633 Imputed A ADD 442 34 80 76 24 109 119 rs6040633 Imputed A GEN 442 34 80 76 24 109 119 rs6040634 Imputed T ADD 441 34 81 75 24 109 118 rs6040634 Imputed T GEN 441 34 81 75 24 109 118 rs6040636 Imputed T ADD 443 34 79 78 24 109 119 rs6040636 Imputed T GEN 443 34 79 78 24 109 119 rs6040638 Imputed C ADD 443 34 80 77 24 109 119 rs6040638 Imputed C GEN 443 34 80 77 24 109 119 rs6040644 Imputed A ADD 443 34 80 77 24 109 119 rs6040644 Imputed A GEN 443 34 80 77 24 109 119 rs6040667 Imputed T ADD 424 34 79 69 24 108 110 rs6040667 Imputed T GEN 424 34 79 69 24 108 110 rs6040668 Imputed C ADD 440 33 82 75 23 111 116 rs6040668 Imputed C GEN 440 33 82 75 23 111 116 rs6053005 Imputed C DOM 275 41 45 33 55 76 25 rs6054405 Imputed A REC 443 31 82 78 41 111 100 rs6054427 Genotyped G GEN 443 29 78 84 39 113 100 rs6075186 Imputed G DOM 443 8 52 131 8 65 179 rs608278 Imputed A ADD 351 31 75 45 33 101 66 rs6111540 Imputed A ADD 380 35 80 51 53 93 68 rs6131206 Imputed C ADD 424 23 75 86 15 87 138 rs6131208 Imputed T ADD 440 33 79 77 23 109 119 rs6131208 Imputed T GEN 440 33 79 77 23 109 119 rs6131919 Imputed G DOM 443 8 52 131 8 65 179 rs6134243 Imputed C ADD 443 34 80 77 24 109 119 rs6134243 Imputed C GEN 443 34 80 77 24 109 119 rs6136020 Imputed A DOM 441 8 49 134 8 64 178 rs613799 Imputed C DOM 420 26 78 77 24 93 122 rs644041 Imputed G ADD 402 11 77 83 16 87 128 rs644041 Imputed G DOM 402 11 77 83 16 87 128 rs6464377 Imputed C DOM 443 0 27 164 3 31 218 rs6474230 Imputed T DOM 443 9 87 95 19 90 143 rs6476565 Imputed A DOM 442 2 32 156 2 37 213 rs6511286 Imputed T ADD 442 24 84 82 33 97 122 rs6541829 Genotyped C REC 443 24 59 108 17 110 125 rs6544721 Imputed G DOM 436 11 78 100 21 83 143 rs6544728 Imputed T DOM 439 10 81 97 21 84 146 rs6565910 Imputed G DOM 433 15 79 93 19 102 125 rs6581985 Imputed G GEN 408 22 81 72 13 103 117 rs6581985 Imputed G REC 408 22 81 72 13 103 117 rs6685186 Imputed T ADD 426 23 84 76 26 119 98 rs6685186 Imputed T GEN 426 23 84 76 26 119 98 rs670593 Imputed A REC 442 19 107 64 50 109 93 rs6722640 Imputed T DOM 441 37 81 73 57 125 68 rs6746170 Imputed A DOM 442 11 84 96 21 86 144 rs6757316 Imputed A GEN 431 31 108 46 36 130 80 rs6805139 Imputed G DOM 442 67 81 43 76 101 74 rs6808571 Imputed G ADD 440 5 47 138 3 61 186 rs6816479 Imputed A REC 430 22 76 85 36 112 99 rs6865976 Imputed C DOM 401 38 92 44 46 120 61 rs687047 Imputed C ADD 443 0 32 159 5 60 187 rs6871041 Imputed G DOM 418 16 62 104 15 112 109 rs688358 Imputed A ADD 427 0 32 154 5 58 178 rs6908481 Imputed C REC 400 35 78 58 37 113 79 rs6917224 Imputed A ADD 441 33 75 82 37 117 97 rs6917224 Imputed A GEN 441 33 75 82 37 117 97 rs6920677 Imputed G DOM 438 25 93 71 45 112 92 rs6994498 Imputed G DOM 443 9 87 95 19 90 143 rs6998772 Imputed T DOM 442 0 18 173 0 20 231 rs7022281 Imputed C ADD 441 16 98 75 47 118 87 rs7022281 Imputed C GEN 441 16 98 75 47 118 87 rs7022281 Imputed C REC 441 16 98 75 47 118 87 rs7043983 Imputed T DOM 438 2 30 156 2 36 212 rs7077799 Imputed A DOM 442 29 83 79 27 101 123 rs7088947 Imputed A ADD 436 0 14 173 0 31 218 rs7089661 Imputed C DOM 442 28 84 79 25 103 123 rs7102072 Imputed A DOM 439 10 78 101 18 100 132 rs710832 Genotyped A REC 443 6 70 115 17 101 134 rs712531 Imputed A DOM 275 0 2 118 0 1 154 rs7129817 Imputed T ADD 441 20 87 82 28 119 105 rs7134262 Imputed T GEN 438 29 85 76 21 111 116 rs7134262 Imputed T REC 438 29 85 76 21 111 116 rs7138300 Imputed C ADD 432 30 90 65 63 116 68 rs7138300 Imputed C DOM 432 30 90 65 63 116 68 rs722927 Imputed G ADD 435 0 21 165 1 31 217 rs722927 Imputed G DOM 435 0 21 165 1 31 217 rs726424 Genotyped G ADD 443 18 100 73 47 115 90 rs726424 Genotyped G GEN 443 18 100 73 47 115 90 rs7295817 Imputed C ADD 424 23 93 66 55 114 73 rs7295817 Imputed C GEN 424 23 93 66 55 114 73 rs7295817 Imputed C REC 424 23 93 66 55 114 73 rs7297372 Imputed A ADD 435 50 95 43 86 120 41 rs7297372 Imputed A GEN 435 50 95 43 86 120 41 rs7298255 Imputed A ADD 443 34 92 65 67 115 70 rs7298255 Imputed A DOM 443 34 92 65 67 115 70 rs7305832 Imputed C GEN 442 29 85 77 21 112 118 rs7305832 Imputed C REC 442 29 85 77 21 112 118 rs737542 Imputed A REC 425 23 55 105 16 103 123 rs742827 Imputed A ADD 437 33 82 75 23 109 115 rs742827 Imputed A GEN 437 33 82 75 23 109 115 rs7446891 Imputed G DOM 443 27 65 99 33 119 100 rs7448641 Imputed C ADD 443 3 22 166 7 23 222 rs7448641 Imputed C DOM 443 3 22 166 7 23 222 rs7460605 Imputed G DOM 412 33 100 46 35 118 80 rs7468898 Imputed T ADD 426 44 87 51 48 131 65 rs7468898 Imputed T GEN 426 44 87 51 48 131 65 rs7501186 Imputed A DOM 443 3 62 126 8 44 200 rs755117 Imputed A DOM 418 7 39 135 10 66 161 rs7557560 Imputed T GEN 437 14 48 126 12 83 154 rs7557560 Imputed T REC 437 14 48 126 12 83 154 rs7562462 Imputed T DOM 436 31 93 67 44 135 66 rs757173 Genotyped G DOM 443 23 100 68 26 133 93 rs7607447 Imputed T REC 410 30 72 75 19 101 113 rs7639053 Imputed A ADD 443 10 63 118 12 84 156 rs7648163 Imputed C REC 421 22 72 86 31 96 114 rs7651273 Imputed A GEN 442 7 59 124 8 66 178 rs7653190 Imputed C ADD 433 10 59 116 12 83 153 rs7653685 Genotyped C DOM 443 1 35 155 3 52 197 rs7684899 Imputed C DOM 417 6 37 139 7 81 147 rs7701604 Imputed G ADD 443 3 22 166 7 23 222 rs7701604 Imputed G DOM 443 3 22 166 7 23 222 rs7703676 Imputed C ADD 443 3 22 166 7 23 222 rs7703676 Imputed C DOM 443 3 22 166 7 23 222 rs7711358 Imputed A DOM 443 26 66 99 34 118 100 rs7713251 Imputed C REC 433 22 69 98 26 99 119 rs7737608 Imputed G DOM 399 18 74 79 29 109 90 rs7755903 Imputed A GEN 426 29 95 62 43 112 85 rs7762993 Imputed A ADD 431 2 65 119 3 82 160 rs7762993 Imputed A DOM 431 2 65 119 3 82 160 rs7767265 Imputed G DOM 430 9 79 99 7 99 137 rs7769415 Imputed C GEN 433 35 84 68 23 100 123 rs7771264 Imputed T DOM 441 14 67 108 18 88 146 rs7795792 Imputed T REC 440 30 89 72 55 117 77 rs7806481 Imputed G REC 443 50 83 58 50 138 64 rs7808536 Imputed G DOM 409 8 59 112 7 63 160 rs7814819 Imputed G ADD 250 1 25 80 1 15 128 rs7814819 Imputed G DOM 250 1 25 80 1 15 128 rs7815952 Imputed T DOM 442 0 18 173 0 20 231 rs7834090 Imputed T DOM 442 0 18 173 0 20 231 rs7859250 Imputed C DOM 442 2 32 156 2 37 213 rs7863577 Genotyped A ADD 443 6 30 155 5 44 203 rs7863577 Genotyped A DOM 443 6 30 155 5 44 203 rs7902140 Imputed C ADD 442 5 53 133 4 79 168 rs7921834 Imputed C DOM 440 28 83 79 26 101 123 rs7939893 Imputed C ADD 441 22 62 106 29 124 98 rs7939893 Imputed C DOM 441 22 62 106 29 124 98 rs7955901 Imputed C ADD 440 34 91 65 67 115 68 rs7955901 Imputed C DOM 440 34 91 65 67 115 68 rs7956274 Imputed T ADD 426 30 88 64 63 113 68 rs7956274 Imputed T DOM 426 30 88 64 63 113 68 rs7957932 Imputed G ADD 439 35 92 64 67 117 64 rs7957932 Imputed G DOM 439 35 92 64 67 117 64 rs7984294 Imputed A DOM 437 2 47 139 1 35 213 rs7994286 Imputed A ADD 436 2 53 132 1 46 202 rs7994286 Imputed A DOM 436 2 53 132 1 46 202 rs8038229 Genotyped A ADD 443 12 73 106 28 110 114 rs8038229 Genotyped A DOM 443 12 73 106 28 110 114 rs8043336 Imputed C GEN 418 23 82 73 35 104 101 rs8043336 Imputed C REC 418 23 82 73 35 104 101 rs8054431 Imputed T DOM 399 19 92 61 24 116 87 rs8066502 Imputed T DOM 442 2 41 148 8 82 161 rs8068714 Imputed T DOM 442 2 41 147 9 82 161 rs892575 Imputed T ADD 442 9 70 112 13 86 152 rs892583 Imputed G ADD 438 9 68 111 12 84 154 rs915494 Imputed A ADD 422 29 79 78 22 91 123 rs915494 Imputed A DOM 422 29 79 78 22 91 123 rs917295 Imputed G DOM 443 27 65 99 33 119 100 rs922594 Imputed T DOM 443 21 79 91 34 130 88 rs9301653 Imputed T ADD 438 2 52 134 1 46 203 rs9301653 Imputed T DOM 438 2 52 134 1 46 203 rs9309988 Imputed G DOM 443 1 35 155 3 52 197 rs9309989 Genotyped C DOM 443 1 35 155 4 54 194 rs9310221 Imputed A DOM 393 29 86 54 36 121 67 rs9327555 Imputed T DOM 443 27 65 99 33 119 100 rs937890 Imputed G DOM 442 2 41 147 9 82 161 rs9454967 Imputed G ADD 441 3 28 159 4 38 209 rs9454967 Imputed G DOM 441 3 28 159 4 38 209 rs9471295 Imputed T DOM 443 5 61 125 3 54 195 rs9477007 Imputed A ADD 436 34 80 74 37 119 92 rs9477007 Imputed A GEN 436 34 80 74 37 119 92 rs9487279 Imputed T DOM 420 29 97 59 52 102 81 rs949016 Imputed C ADD 441 9 67 113 12 84 156 rs9555973 Imputed G ADD 437 2 53 134 1 46 201 rs9555973 Imputed G DOM 437 2 53 134 1 46 201 rs9557510 Imputed G ADD 443 9 46 136 5 54 193 rs9557510 Imputed G DOM 443 9 46 136 5 54 193 rs9560584 Imputed T DOM 435 2 52 131 1 46 203 rs9588770 Imputed T DOM 443 3 54 134 3 47 202 rs9588848 Imputed C ADD 438 2 52 134 1 46 203 rs9588848 Imputed C DOM 438 2 52 134 1 46 203 rs966583 Imputed A ADD 439 26 87 77 44 125 80 rs966583 Imputed A DOM 439 26 87 77 44 125 80 rs974130 Genotyped A REC 443 25 81 85 37 116 99 rs977160 Imputed T ADD 438 9 61 118 11 84 155 rs9812206 Imputed G ADD 442 0 30 161 0 38 213 rs9812206 Imputed G DOM 442 0 30 161 0 38 213 rs9813552 Imputed G ADD 442 0 30 161 1 36 214 rs9813552 Imputed G DOM 442 0 30 161 1 36 214 rs9815037 Imputed T ADD 443 0 30 161 1 36 215 rs9815037 Imputed T DOM 443 0 30 161 1 36 215 rs9825349 Imputed A ADD 443 0 30 161 1 36 215 rs9825349 Imputed A DOM 443 0 30 161 1 36 215 rs9834217 Imputed T ADD 443 0 30 161 1 37 214 rs9834217 Imputed T DOM 443 0 30 161 1 37 214 rs9840460 Imputed T ADD 443 0 30 161 1 37 214 rs9840460 Imputed T DOM 443 0 30 161 1 37 214 rs9840756 Imputed A ADD 437 0 30 160 1 37 209 rs9840756 Imputed A DOM 437 0 30 160 1 37 209 rs9844801 Imputed C DOM 443 1 35 155 3 52 197 rs985375 Imputed A GEN 423 12 68 103 14 94 132 rs9869187 Imputed C ADD 442 0 30 160 0 39 213 rs9869187 Imputed C DOM 442 0 30 160 0 39 213 rs9872327 Imputed T DOM 443 1 35 155 3 52 197 rs9881685 Imputed A ADD 440 0 30 160 0 38 212 rs9881685 Imputed A DOM 440 0 30 160 0 38 212 rs9909499 Imputed C DOM 422 15 92 75 26 83 131 rs9911847 Imputed G DOM 442 2 41 147 9 82 161 rs9958823 Imputed A ADD 438 9 73 108 13 86 149 rs9965248 Imputed T ADD 437 9 61 117 11 84 155

TABLE 12 ALLELE SNP rs # SOURCE (A1) MODEL P P(R) OR OR(R) Q I rs198460 Genotyped G RECESSIVE 2.29E−04 0.000229 1.7469 1.7469 0.3205 0 rs603940 Genotyped G RECESSIVE 4.77E−03 0.004769 0.6036 0.6036 0.9004 0 rs10021016 Genotyped G GENOTYPIC 1.53E−03 0.001532 2.2715 2.2715 0.7583 0 rs1003148 Imputed C ADDITIVE 1.09E−04 0.0001087 0.706 0.706 0.7408 0 rs1003148 Imputed C GENOTYPIC 0.0001585 0.0001585 0.4899 0.4899 0.518 0 rs1003148 Imputed C RECESSIVE 0.001753 0.00218 0.5819 0.5829 0.3099 3.02 rs10046799 Imputed C ADDITIVE 3.21E−04 0.003933 0.724 0.7134 0.2084 36.82 rs10046799 Imputed C GENOTYPIC 0.0005855 0.003461 0.5342 0.5221 0.2386 28.01 rs10051148 Imputed C DOMINANT 1.63E−05 1.63E−05 0.5783 0.5783 0.7565 0 rs10054055 Imputed T DOMINANT 1.71E−05 1.71E−05 0.5791 0.5791 0.7456 0 rs10067895 Imputed A DOMINANT 1.57E−05 1.57E−05 0.5759 0.5759 0.7904 0 rs1008705 Imputed C DOMINANT 8.42E−03 0.00842 1.4761 1.4761 0.9317 0 rs10105871 Imputed C DOMINANT 5.40E−04 0.0005398 1.6092 1.6092 0.4959 0 rs10116807 Imputed A GENOTYPIC 4.73E−04 0.0004726 3.0952 3.0952 0.9876 0 rs10116807 Imputed A RECESSIVE 5.24E−04 5.24E−04 3.0277 3.0277 0.956 0 rs10121941 Imputed C DOMINANT 7.75E−05 7.75E−05 0.5093 0.5093 0.7525 0 rs10128638 Genotyped G DOMINANT 3.84E−04 0.0003837 0.6023 0.6023 0.6707 0 rs1012924 Imputed G ADDITIVE 6.55E−05 6.55E−05 0.5369 0.5369 0.7455 0 rs1012924 Imputed G DOMINANT 4.31E−05 4.31E−05 0.5009 0.5009 0.6615 0 rs1016030 Genotyped G ADDITIVE 7.02E−05 7.02E−05 1.4487 1.4487 0.5994 0 rs1016030 Genotyped G GENOTYPIC 8.31E−05 8.31E−05 2.1351 2.1351 0.6388 0 rs1017558 Imputed A RECESSIVE 9.48E−05 9.48E−05 2.016 2.016 0.6946 0 rs10183431 Imputed T DOMINANT 9.50E−05 9.50E−05 1.6438 1.6438 0.7949 0 rs10195401 Imputed C DOMINANT 8.08E−05 8.08E−05 1.679 1.679 0.7757 0 rs10239416 Imputed A DOMINANT 5.37E−05 5.37E−05 0.5939 0.5939 0.6861 0 rs1032188 Imputed G GENOTYPIC 0.0003684 0.004755 0.411 0.3885 0.2102 36.31 rs1032188 Imputed G RECESSIVE 0.0009593 0.01499 0.4495 0.4153 0.1711 46.62 rs10468988 Imputed G ADDITIVE 2.45E−05 2.45E−05 1.5305 1.5305 0.6802 0 rs10478919 Imputed G DOMINANT 1.10E−05 1.10E−05 0.5722 0.5722 0.6924 0 rs10506623 Imputed C DOMINANT 1.26E−04 0.0001255 0.6039 0.6039 0.8321 0 rs10506626 Imputed A DOMINANT 2.45E−05 2.45E−05 0.5722 0.5722 0.8985 0 rs10509477 Imputed T DOMINANT 1.46E−04 0.000146 1.6135 1.6135 0.3224 0 rs10511071 Imputed C DOMINANT 5.30E−05 8.76E−05 1.9326 1.9381 0.3031 5.72 rs10511072 Imputed G DOMINANT 5.30E−05 8.76E−05 1.9326 1.9381 0.3031 5.72 rs10511199 Imputed C ADDITIVE 9.67E−05 9.67E−05 1.5246 1.5246 0.8383 0 rs10513283 Imputed G GENOTYPIC 8.48E−05 8.48E−05 3.6142 3.6142 0.3734 0 rs10520072 Imputed T DOMINANT 1.41E−05 1.41E−05 0.5759 0.5759 0.7897 0 rs1065639 Imputed C DOMINANT 6.94E−05 6.94E−05 1.7059 1.7059 0.8002 0 rs10733846 Imputed G ADDITIVE 8.04E−06 8.04E−06 0.5881 0.5881 0.4857 0 rs10733846 Imputed G DOMINANT 7.17E−05 7.17E−05 0.5809 0.5809 0.6915 0 rs10737390 Imputed T DOMINANT 5.78E−05 5.78E−05 0.5929 0.5929 0.5632 0 rs10749293 Imputed G DOMINANT 9.87E−05 0.0001063 1.6321 1.6316 0.3156 0.71 rs10752159 Imputed G DOMINANT 0.0003712 0.001012 1.5856 1.5961 0.2786 14.82 rs10753760 Imputed T ADDITIVE 9.28E−05 9.28E−05 1.4355 1.4355 0.8085 0 rs10753760 Imputed T GENOTYPIC 8.65E−05 8.65E−05 2.1142 2.1142 0.8438 0 rs10757887 Imputed C DOMINANT 8.87E−05 8.87E−05 0.604 0.604 0.8342 0 rs10758326 Imputed A ADDITIVE 8.55E−04 0.0008545 0.7335 0.7335 0.95 0 rs10758326 Imputed A GENOTYPIC 0.001038 0.001038 0.5194 0.5194 0.7462 0 rs10758326 Imputed A RECESSIVE 6.13E−03 0.006132 0.603 0.603 0.5469 0 rs10762236 Genotyped G ADDITIVE 2.14E−05 2.14E−05 0.6093 0.6093 0.584 0 rs10765769 Imputed C ADDITIVE 2.91E−05 2.91E−05 1.474 1.474 0.756 0 rs10765769 Imputed C GENOTYPIC 5.17E−05 5.17E−05 2.1499 2.1499 0.7054 0 rs10784891 Imputed C ADDITIVE 0.0003093 0.0003093 0.711 0.711 0.6979 0 rs10784891 Imputed C DOMINANT 5.54E−05 5.54E−05 0.5722 0.5722 0.9756 0 rs10787923 Imputed G DOMINANT 6.47E−05 1.80E−04 1.6581 1.6522 0.2931 9.54 rs10787949 Imputed A DOMINANT 1.77E−04 0.001337 1.6068 1.5927 0.2585 21.69 rs10787951 Imputed G DOMINANT 0.0001766 0.001337 1.6068 1.5927 0.2585 21.69 rs10787983 Imputed C DOMINANT 1.40E−04 0.0004442 1.6153 1.6079 0.2874 11.66 rs10788380 Imputed C ADDITIVE 0.0005839 0.0005839 1.3678 1.3678 0.66 0 rs10788380 Imputed C DOMINANT 4.48E−04 4.48E−04 1.7138 1.7138 0.8013 0 rs10788380 Imputed C GENOTYPIC 0.0004936 0.0004936 1.8999 1.8999 0.7216 0 rs10814418 Imputed G DOMINANT 8.78E−05 8.78E−05 0.5119 0.5119 0.7369 0 rs10831417 Imputed A ADDITIVE 1.96E−05 1.96E−05 1.4929 1.4929 0.5559 0 rs10831417 Imputed A GENOTYPIC 1.73E−05 1.73E−05 2.3097 2.3097 0.6056 0 rs10831422 Imputed C ADDITIVE 5.92E−05 5.92E−05 1.4561 1.4561 0.7103 0 rs10831422 Imputed C GENOTYPIC 4.43E−05 4.43E−05 2.2133 2.2133 0.7026 0 rs10862931 Imputed C GENOTYPIC 9.68E−05 9.68E−05 0.4267 0.4267 0.4634 0 rs10865197 Imputed C DOMINANT 9.34E−05 9.34E−05 1.6437 1.6437 0.7947 0 rs10871302 Imputed A DOMINANT 0.009612 0.009612 1.4552 1.4552 0.5024 0 rs10877463 Imputed C DOMINANT 2.64E−03 0.002642 0.6825 0.6825 0.4291 0 rs10877468 Imputed C DOMINANT 2.82E−03 0.002816 0.6833 0.6833 0.3554 0 rs10879240 Imputed C ADDITIVE 5.13E−04 0.001027 0.6811 0.6808 0.2896 10.85 rs10879242 Imputed A DOMINANT 2.95E−05 2.95E−05 0.5555 0.5555 0.3862 0 rs10879245 Imputed G DOMINANT 2.95E−05 2.95E−05 0.5555 0.5555 0.3862 0 rs10879249 Imputed T DOMINANT 1.19E−04 0.0001194 0.6021 0.6021 0.7426 0 rs10886452 Imputed A DOMINANT 1.77E−04 0.001337 1.6068 1.5927 0.2585 21.69 rs10886463 Imputed C DOMINANT 1.54E−04 6.44E−04 1.6141 1.6047 0.2786 14.82 rs10886465 Imputed A DOMINANT 0.00019 0.0006506 1.604 1.596 0.2834 13.1 rs10886526 Imputed C DOMINANT 1.74E−04 0.0001743 1.6053 1.6053 0.3255 0 rs10902437 Imputed G ADDITIVE 1.74E−03 1.74E−03 1.3336 1.3336 0.3478 0 rs10941126 Imputed G ADDITIVE 2.13E−05 2.13E−05 0.1976 0.1976 0.798 0 rs10941126 Imputed G DOMINANT 3.85E−05 3.85E−05 0.2007 0.2007 0.8145 0 rs10947871 Imputed A DOMINANT 2.08E−03 0.002076 1.5391 1.5391 0.8556 0 rs10972978 Imputed G DOMINANT 6.77E−05 6.77E−05 0.5018 0.5018 0.7975 0 rs10973012 Imputed A DOMINANT 7.75E−05 7.75E−05 0.5093 0.5093 0.7525 0 rs10974028 Genotyped G ADDITIVE 9.41E−05 9.41E−05 0.6153 0.6153 0.8548 0 rs10974028 Genotyped G DOMINANT 1.15E−05 1.15E−05 0.5349 0.5349 0.733 0 rs11021302 Imputed A ADDITIVE 6.97E−05 6.97E−05 1.4505 1.4505 0.6892 0 rs11021302 Imputed A GENOTYPIC 4.72E−05 4.72E−05 2.2069 2.2069 0.695 0 rs11099644 Imputed G RECESSIVE 9.48E−05 9.48E−05 2.016 2.016 0.6946 0 rs11138315 Imputed G ADDITIVE 0.002501 0.002501 0.6333 0.6333 0.4998 0 rs11149802 Imputed T DOMINANT 9.61E−03 0.009612 1.4552 1.4552 0.5024 0 rs1116596 Imputed T DOMINANT 1.10E−05 1.10E−05 0.5722 0.5722 0.6924 0 rs11178531 Imputed A ADDITIVE 0.001066 0.001066 0.7412 0.7412 0.6947 0 rs11178531 Imputed A DOMINANT 5.75E−05 5.75E−05 0.572 0.572 0.8111 0 rs11178575 Imputed C GENOTYPIC 0.002546 0.002546 1.8735 1.8735 0.3907 0 rs11178575 Imputed C RECESSIVE 0.001194 0.001194 1.8848 1.8848 0.3922 0 rs11178577 Imputed T GENOTYPIC 0.002616 0.002616 1.87 1.87 0.3948 0 rs11178577 Imputed T RECESSIVE 0.001154 0.001154 1.8884 1.8884 0.4001 0 rs11178583 Imputed A DOMINANT 7.82E−05 7.82E−05 0.5918 0.5918 0.6676 0 rs11178589 Imputed T DOMINANT 0.0001977 0.0001977 0.6108 0.6108 0.7703 0 rs11178594 Imputed C DOMINANT 8.34E−05 8.34E−05 0.5951 0.5951 0.7778 0 rs11178602 Imputed T DOMINANT 7.78E−05 7.78E−05 0.5942 0.5942 0.6786 0 rs11178648 Imputed T DOMINANT 2.45E−05 2.45E−05 0.576 0.576 0.8248 0 rs11198877 Imputed T DOMINANT 0.0001766 0.001337 1.6068 1.5927 0.2585 21.69 rs11198942 Imputed T DOMINANT 0.0001123 0.0002521 1.6276 1.6227 0.2973 7.94 rs11221075 Imputed A ADDITIVE 0.002456 0.002456 0.6561 0.6561 0.6722 0 rs11242020 Imputed T DOMINANT 8.24E−06 8.24E−06 0.5675 0.5675 0.7214 0 rs11242021 Imputed T DOMINANT 1.39E−05 1.39E−05 0.5753 0.5753 0.7864 0 rs11242022 Imputed T DOMINANT 1.90E−05 1.90E−05 0.5805 0.5805 0.7156 0 rs11242023 Imputed T DOMINANT 1.94E−05 1.94E−05 0.5807 0.5807 0.7577 0 rs1149350 Imputed A DOMINANT 8.78E−05 8.78E−05 1.6713 1.6713 0.3701 0 rs1150143 Imputed G DOMINANT 5.41E−05 5.41E−05 1.6852 1.6852 0.741 0 rs11576627 Imputed T ADDITIVE 2.21E−04 0.0002213 1.6268 1.6268 0.4154 0 rs11576627 Imputed T DOMINANT 0.0002026 0.0002026 1.7055 1.7055 0.4813 0 rs11602189 Imputed A DOMINANT 5.90E−05 5.90E−05 0.6007 0.6007 0.9545 0 rs11605163 Imputed A DOMINANT 6.08E−05 6.08E−05 2.1075 2.1075 0.8875 0 rs11615214 Imputed G ADDITIVE 3.71E−05 3.71E−05 0.6853 0.6853 0.3765 0 rs11615214 Imputed G GENOTYPIC 9.43E−05 0.001874 0.4648 0.4738 0.2292 30.83 rs11642394 Imputed C DOMINANT 0.009359 0.009359 1.4572 1.4572 0.5108 0 rs11644943 Imputed A ADDITIVE 0.001027 0.001027 1.4247 1.4247 0.3922 0 rs11656608 Imputed T DOMINANT 4.43E−03 0.004428 0.6695 0.6695 0.7811 0 rs11661309 Imputed A ADDITIVE 3.52E−05 3.52E−05 0.6163 0.6163 0.8488 0 rs11661309 Imputed A DOMINANT 8.21E−05 8.21E−05 0.5852 0.5852 0.7907 0 rs11666131 Imputed A ADDITIVE 6.47E−05 6.47E−05 1.5364 1.5364 0.8474 0 rs11743355 Imputed C ADDITIVE 2.07E−05 2.07E−05 0.1796 0.1796 0.7144 0 rs11743355 Imputed C DOMINANT 3.53E−05 3.53E−05 0.1817 0.1817 0.7255 0 rs11746806 Imputed T ADDITIVE 3.41E−05 3.41E−05 0.2206 0.2206 0.9267 0 rs11746806 Imputed T DOMINANT 6.55E−05 6.55E−05 0.2253 0.2253 0.9509 0 rs11746959 Imputed T ADDITIVE 2.13E−05 2.13E−05 0.1976 0.1976 0.798 0 rs11746959 Imputed T DOMINANT 3.85E−05 3.85E−05 0.2007 0.2007 0.8145 0 rs11749272 Imputed T DOMINANT 1.23E−05 1.23E−05 0.5734 0.5734 0.7009 0 rs11901899 Imputed A DOMINANT 0.0003007 0.0003007 1.5824 1.5824 0.3922 0 rs11926319 Imputed G ADDITIVE 7.83E−07 7.83E−07 0.4343 0.4343 0.3992 0 rs11926319 Imputed G DOMINANT 1.01E−06 1.01E−06 0.4237 0.4237 0.4489 0 rs11956952 Imputed C DOMINANT 0.0009505 0.0009505 0.6564 0.6564 0.7028 0 rs12025826 Imputed G DOMINANT 0.0005142 0.0005142 1.5794 1.5794 0.3682 0 rs1204522 Imputed C GENOTYPIC 8.61E−05 8.61E−05 0.4353 0.4353 0.6828 0 rs1204524 Imputed A GENOTYPIC 8.54E−05 8.54E−05 0.4351 0.4351 0.6472 0 rs12153185 Imputed T DOMINANT 1.57E−05 1.57E−05 0.5759 0.5759 0.7904 0 rs12182651 Imputed T ADDITIVE 7.03E−06 7.03E−06 2.1926 2.1926 0.7348 0 rs12182651 Imputed T DOMINANT 1.21E−06 1.21E−06 2.4795 2.4795 0.5648 0 rs12193568 Imputed G DOMINANT 0.000391 0.004677 1.7403 1.8042 0.2164 34.55 rs12264914 Imputed C DOMINANT 1.11E−02 0.01109 0.6442 0.6442 0.505 0 rs12307767 Imputed C DOMINANT 0.001811 0.001811 0.6667 0.6667 0.3444 0 rs1232298 Imputed G RECESSIVE 0.0006722 0.006032 2.0566 2.0955 0.2088 36.69 rs12407412 Imputed C ADDITIVE 0.0002213 0.0002213 1.6268 1.6268 0.4154 0 rs12407412 Imputed C DOMINANT 2.03E−04 0.0002026 1.7055 1.7055 0.4813 0 rs12420184 Imputed G DOMINANT 6.39E−05 6.39E−05 0.5645 0.5645 0.7037 0 rs12422750 Imputed A DOMINANT 0.00369 0.00369 0.6919 0.6919 0.3546 0 rs12446951 Imputed A ADDITIVE 6.52E−05 6.52E−05 2.3413 2.3413 0.3314 0 rs12446951 Imputed A DOMINANT 0.0001226 0.0001226 2.3135 2.3135 0.3285 0 rs12457400 Imputed G DOMINANT 0.0009766 0.0009766 0.5884 0.5884 0.6035 0 rs1247340 Imputed C DOMINANT 8.32E−05 8.32E−05 1.6742 1.6742 0.3604 0 rs1247341 Imputed C DOMINANT 7.02E−05 7.02E−05 1.684 1.684 0.3274 0 rs12521291 Imputed G ADDITIVE 6.67E−05 6.67E−05 0.6857 0.6857 0.9769 0 rs12526849 Imputed T ADDITIVE 7.52E−05 7.52E−05 1.4208 1.4208 0.6829 0 rs12526849 Imputed T GENOTYPIC 7.73E−05 7.73E−05 2.0445 2.0445 0.7856 0 rs12543110 Imputed G DOMINANT 0.0001096 0.0001096 1.6401 1.6401 0.5183 0 rs12678600 Imputed A DOMINANT 9.83E−05 9.83E−05 0.6104 0.6104 0.9092 0 rs12719415 Imputed T DOMINANT 8.10E−06 8.10E−06 0.5662 0.5662 0.7128 0 rs12831292 Imputed G DOMINANT 9.77E−05 9.77E−05 0.5982 0.5982 0.6795 0 rs12923993 Imputed C DOMINANT 0.009359 0.009359 1.4572 1.4572 0.5108 0 rs12936964 Imputed T DOMINANT 9.02E−05 9.02E−05 1.6688 1.6688 0.7618 0 rs12960663 Imputed G ADDITIVE 5.61E−05 5.61E−05 0.6241 0.6241 0.7884 0 rs13038146 Imputed C ADDITIVE 0.0005045 0.0005045 1.3708 1.3708 0.7263 0 rs13038146 Imputed C GENOTYPIC 0.0006517 0.0006517 1.9308 1.9308 0.8764 0 rs13134222 Imputed A GENOTYPIC 9.86E−05 9.86E−05 0.3011 0.3011 0.8224 0 rs13172910 Imputed A DOMINANT 0.0008666 0.0008666 0.6547 0.6547 0.7269 0 rs13194907 Imputed A ADDITIVE 1.34E−05 1.34E−05 2.303 2.303 0.9028 0 rs13194907 Imputed A DOMINANT 5.24E−06 5.24E−06 2.505 2.505 0.845 0 rs13195745 Imputed A ADDITIVE 1.34E−05 1.34E−05 2.303 2.303 0.9028 0 rs13195745 Imputed A DOMINANT 5.24E−06 5.24E−06 2.505 2.505 0.845 0 rs1321432 Imputed A RECESSIVE 3.78E−05 3.78E−05 2.1221 2.1221 0.4916 0 rs1321457 Imputed G RECESSIVE 7.32E−05 7.32E−05 2.0656 2.0656 0.4383 0 rs13265054 Imputed T DOMINANT 1.26E−04 0.0001261 0.6144 0.6144 0.8838 0 rs13282131 Imputed C GENOTYPIC 6.83E−04 0.0006831 1.8412 1.8412 0.8885 0 rs13353526 Imputed C DOMINANT 4.66E−05 4.66E−05 1.9371 1.9371 0.4192 0 rs1336382 Imputed T DOMINANT 1.46E−04 1.46E−04 1.6135 1.6135 0.3224 0 rs1336383 Imputed T DOMINANT 0.000146 0.000146 1.6135 1.6135 0.3224 0 rs1336407 Imputed T DOMINANT 0.000146 0.000146 1.6135 1.6135 0.3224 0 rs1336409 Imputed T DOMINANT 1.62E−04 0.0002489 1.6085 1.6059 0.3065 4.35 rs1336596 Imputed A DOMINANT 5.25E−05 5.25E−05 0.5951 0.5951 0.5868 0 rs1343560 Imputed T ADDITIVE 7.42E−05 7.42E−05 0.5393 0.5393 0.7611 0 rs1343560 Imputed T DOMINANT 4.91E−05 4.91E−05 0.5034 0.5034 0.6771 0 rs1361987 Imputed T GENOTYPIC 9.25E−05 9.25E−05 0.4404 0.4404 0.5591 0 rs1386153 Imputed T ADDITIVE 8.36E−05 8.36E−05 0.6841 0.6841 0.8357 0 rs1386153 Imputed T DOMINANT 5.01E−05 5.01E−05 0.599 0.599 0.9393 0 rs1394015 Imputed C DOMINANT 5.43E−05 5.43E−05 1.7294 1.7294 0.6444 0 rs1407038 Imputed A RECESSIVE 5.83E−05 5.83E−05 2.0823 2.0823 0.4381 0 rs1407039 Imputed A RECESSIVE 9.91E−05 9.91E−05 2.0129 2.0129 0.5236 0 rs1412802 Imputed T GENOTYPIC 0.0007205 0.0007205 0.4264 0.4264 0.7234 0 rs1414865 Imputed T DOMINANT 0.0001766 0.001337 1.6068 1.5927 0.2585 21.69 rs1414873 Imputed A DOMINANT 0.000122 0.0001815 1.6219 1.6195 0.3077 3.88 rs1414876 Imputed C DOMINANT 0.000122 0.0001815 1.6219 1.6195 0.3077 3.88 rs1418671 Imputed C RECESSIVE 9.36E−06 9.36E−06 2.1762 2.1762 0.8027 0 rs1419490 Genotyped T GENOTYPIC 8.94E−05 8.94E−05 0.4398 0.4398 0.5307 0 rs1434507 Imputed A ADDITIVE 7.02E−05 7.02E−05 1.4932 1.4932 0.6454 0 rs1434508 Imputed T ADDITIVE 9.01E−05 9.01E−05 1.4841 1.4841 0.6551 0 rs1435205 Imputed A ADDITIVE 9.67E−05 9.67E−05 1.5246 1.5246 0.8383 0 rs1443928 Imputed C RECESSIVE 6.72E−05 6.72E−05 0.5586 0.5586 0.6157 0 rs1452235 Imputed G GENOTYPIC 7.97E−05 7.97E−05 0.4269 0.4269 0.4549 0 rs1452236 Imputed G GENOTYPIC 7.57E−05 7.57E−05 0.4257 0.4257 0.4487 0 rs1452237 Imputed G GENOTYPIC 7.97E−05 7.97E−05 0.4269 0.4269 0.4549 0 rs1452243 Genotyped T GENOTYPIC 7.97E−05 7.97E−05 0.4269 0.4269 0.4549 0 rs1463768 Genotyped G RECESSIVE 4.61E−04 0.01223 1.8009 1.8886 0.1522 51.22 rs1463769 Imputed G RECESSIVE 3.34E−04 0.007743 1.8295 1.9062 0.171 46.65 rs1472435 Imputed A ADDITIVE 0.0002548 0.001662 0.5022 0.4908 0.2466 25.51 rs1472435 Imputed A DOMINANT 5.02E−04 0.004002 0.5076 0.4938 0.2238 32.42 rs1476714 Imputed A DOMINANT 1.19E−05 1.19E−05 0.5726 0.5726 0.7844 0 rs1495159 Imputed G ADDITIVE 1.61E−05 1.61E−05 0.6509 0.6509 0.7963 0 rs1495159 Imputed G GENOTYPIC 7.70E−05 7.70E−05 0.3915 0.3915 0.8463 0 rs1495375 Imputed A DOMINANT 0.0001025 0.0001025 0.5962 0.5962 0.6659 0 rs1495376 Imputed T DOMINANT 2.01E−05 2.01E−05 0.5347 0.5347 0.3504 0 rs1495377 Imputed G DOMINANT 3.97E−05 7.56E−05 0.5484 0.5467 0.2993 7.17 rs1495381 Imputed T GENOTYPIC 0.0009636 0.0009636 1.8616 1.8616 0.5241 0 rs1495381 Imputed T RECESSIVE 0.0001018 0.0001018 1.9326 1.9326 0.6962 0 rs1498992 Imputed G DOMINANT 1.48E−04 0.0001483 0.6213 0.6213 0.4944 0 rs1499001 Imputed T DOMINANT 0.0001967 0.0001967 0.6214 0.6214 0.5607 0 rs1512988 Imputed A DOMINANT 9.29E−05 9.29E−05 0.5976 0.5976 0.8745 0 rs1512989 Imputed T DOMINANT 9.29E−05 9.29E−05 0.5976 0.5976 0.8745 0 rs1512991 Imputed T ADDITIVE 1.02E−03 0.001016 0.7391 0.7391 0.9158 0 rs1512991 Imputed T DOMINANT 8.22E−05 8.22E−05 0.5816 0.5816 0.9166 0 rs1516855 Imputed G RECESSIVE 7.25E−05 7.25E−05 2.1755 2.1755 0.4759 0 rs1527450 Imputed T ADDITIVE 2.46E−05 2.46E−05 1.486 1.486 0.5328 0 rs1527450 Imputed T GENOTYPIC 2.19E−05 2.19E−05 2.2868 2.2868 0.5806 0 rs1567740 Imputed T DOMINANT 8.80E−05 8.80E−05 0.596 0.596 0.8322 0 rs1572573 Imputed A ADDITIVE 2.45E−05 2.45E−05 1.6309 1.6309 0.4087 0 rs1572573 Imputed A DOMINANT 4.83E−06 4.83E−06 1.8564 1.8564 0.424 0 rs1584003 Imputed C DOMINANT 3.11E−05 3.11E−05 1.8445 1.8445 0.5284 0 rs1584005 Imputed C DOMINANT 4.62E−05 4.62E−05 1.8227 1.8227 0.5661 0 rs1585771 Imputed G ADDITIVE 8.69E−05 8.69E−05 1.4824 1.4824 0.9898 0 rs1592015 Imputed G DOMINANT 6.94E−05 6.94E−05 0.5728 0.5728 0.3692 0 rs1594885 Imputed A ADDITIVE 3.75E−05 3.75E−05 1.5121 1.5121 0.6724 0 rs1603232 Imputed A DOMINANT 8.75E−05 8.75E−05 0.5656 0.5656 0.3264 0 rs1614565 Imputed C DOMINANT 1.53E−05 1.53E−05 0.5357 0.5357 0.5207 0 rs1648200 Imputed G ADDITIVE 0.0002847 0.0002847 1.4867 1.4867 0.9072 0 rs16877387 Imputed C GENOTYPIC 6.36E−05 6.36E−05 2.2411 2.2411 0.7064 0 rs16877387 Imputed C RECESSIVE 2.50E−05 2.50E−05 2.2227 2.2227 0.938 0 rs16938626 Imputed G DOMINANT 1.07E−04 0.0001071 0.6116 0.6116 0.7404 0 rs1694334 Imputed G ADDITIVE 8.91E−05 8.91E−05 0.6436 0.6436 0.6943 0 rs16998821 Imputed C DOMINANT 6.94E−05 6.94E−05 0.5728 0.5728 0.3692 0 rs1700400 Imputed T ADDITIVE 4.31E−05 4.31E−05 0.6508 0.6508 0.3976 0 rs17007620 Imputed G ADDITIVE 2.46E−05 2.46E−05 1.6003 1.6003 0.8148 0 rs17007620 Imputed G DOMINANT 3.02E−05 3.02E−05 1.7521 1.7521 0.9606 0 rs17023290 Imputed C DOMINANT 5.30E−05 8.76E−05 1.9326 1.9381 0.3031 5.72 rs17047957 Imputed C DOMINANT 0.001192 0.001192 1.5648 1.5648 0.6233 0 rs1705237 Imputed A DOMINANT 1.05E−05 1.05E−05 0.5283 0.5283 0.5228 0 rs1705261 Imputed A GENOTYPIC 0.0008093 0.0008093 1.8782 1.8782 0.4997 0 rs1705261 Imputed A RECESSIVE 0.0001018 0.0001018 1.9326 1.9326 0.6962 0 rs17076972 Imputed C ADDITIVE 6.68E−05 6.68E−05 1.4316 1.4316 0.9615 0 rs17076972 Imputed C GENOTYPIC 4.84E−05 4.84E−05 2.0743 2.0743 0.953 0 rs17076972 Imputed C RECESSIVE 5.68E−05 5.68E−05 1.8279 1.8279 0.9528 0 rs17189710 Imputed T ADDITIVE 0.0005045 0.0005045 1.3708 1.3708 0.7263 0 rs17189710 Imputed T GENOTYPIC 0.0006517 0.0006517 1.9308 1.9308 0.8764 0 rs17196143 Imputed A ADDITIVE 8.38E−05 8.38E−05 1.5602 1.5602 0.9412 0 rs17353809 Imputed G ADDITIVE 5.27E−05 5.27E−05 1.5478 1.5478 0.7656 0 rs17368986 Imputed A GENOTYPIC 8.61E−05 8.61E−05 3.6103 3.6103 0.3631 0 rs17369097 Imputed A GENOTYPIC 9.78E−05 9.78E−05 3.572 3.572 0.5084 0 rs17434511 Imputed C GENOTYPIC 8.13E−05 8.13E−05 3.6271 3.6271 0.3688 0 rs17434589 Imputed C GENOTYPIC 7.42E−05 7.42E−05 3.6546 3.6546 0.3705 0 rs17434603 Imputed G GENOTYPIC 8.48E−05 8.48E−05 3.6142 3.6142 0.3734 0 rs17434840 Imputed C GENOTYPIC 9.78E−05 9.78E−05 3.572 3.572 0.5084 0 rs17446418 Imputed G DOMINANT 3.25E−05 3.25E−05 0.587 0.587 0.3535 0 rs17530747 Imputed T DOMINANT 2.26E−05 2.63E−05 0.5795 0.5797 0.3143 1.26 rs17604285 Imputed C ADDITIVE 1.05E−05 1.05E−05 0.4906 0.4906 0.4675 0 rs17604285 Imputed C DOMINANT 9.86E−06 9.86E−06 0.4707 0.4707 0.5868 0 rs17662322 Imputed T DOMINANT 0.0001449 0.0001449 0.6002 0.6002 0.4533 0 rs17769826 Imputed T ADDITIVE 5.88E−05 5.88E−05 1.5431 1.5431 0.7499 0 rs17821641 Imputed T ADDITIVE 9.67E−05 9.67E−05 1.5246 1.5246 0.8383 0 rs1782328 Imputed A ADDITIVE 2.46E−05 2.46E−05 0.6019 0.6019 0.8261 0 rs1796337 Imputed T DOMINANT 0.0001492 0.0001492 0.576 0.576 0.7496 0 rs1798083 Imputed C DOMINANT 3.81E−05 3.81E−05 0.5525 0.5525 0.4283 0 rs1798085 Imputed T DOMINANT 1.84E−05 1.84E−05 0.538 0.538 0.506 0 rs1798086 Imputed T DOMINANT 6.52E−06 6.52E−06 0.5214 0.5214 0.5861 0 rs1798089 Imputed C GENOTYPIC 0.0003263 0.0003263 1.9613 1.9613 0.6074 0 rs1798089 Imputed C RECESSIVE 4.85E−05 4.85E−05 1.9649 1.9649 0.6513 0 rs1798090 Imputed C GENOTYPIC 0.0002913 0.0002913 1.9722 1.9722 0.6702 0 rs1798090 Imputed C RECESSIVE 6.28E−05 6.28E−05 1.941 1.941 0.6999 0 rs1832222 Imputed G DOMINANT 0.0001402 0.0004442 1.6153 1.6079 0.2874 11.66 rs1838104 Imputed A ADDITIVE 6.20E−05 6.20E−05 0.6927 0.6927 0.4982 0 rs1838104 Imputed A GENOTYPIC 7.67E−05 7.67E−05 0.4828 0.4828 0.4457 0 rs1868616 Imputed G ADDITIVE 6.07E−05 6.07E−05 0.6201 0.6201 0.3729 0 rs1874313 Imputed A DOMINANT 7.43E−05 7.43E−05 0.5922 0.5922 0.8066 0 rs1884902 Imputed C RECESSIVE 6.21E−05 6.21E−05 2.0651 2.0651 0.5825 0 rs1913201 Imputed G ADDITIVE 0.0004149 0.0004149 0.7177 0.7177 0.6151 0 rs1913201 Imputed G DOMINANT 9.54E−05 9.54E−05 0.5843 0.5843 0.9445 0 rs1913201 Imputed G GENOTYPIC 0.001991 0.001991 0.5555 0.5555 0.4282 0 rs1944279 Imputed A ADDITIVE 2.61E−05 2.61E−05 1.5292 1.5292 0.6713 0 rs198461 Imputed C DOMINANT 0.0001487 0.0001487 0.5632 0.5632 0.3797 0 rs1987179 Imputed T DOMINANT 0.003872 0.003872 0.6885 0.6885 0.8528 0 rs1990023 Imputed T DOMINANT 8.24E−06 8.24E−06 0.5675 0.5675 0.7214 0 rs2016194 Imputed G DOMINANT 1.39E−05 1.39E−05 0.5753 0.5753 0.7864 0 rs2024789 Imputed C ADDITIVE 7.32E−05 7.32E−05 0.7001 0.7001 0.5939 0 rs2024789 Imputed C GENOTYPIC 9.80E−05 9.80E−05 0.4935 0.4935 0.6182 0 rs2024902 Imputed A ADDITIVE 3.48E−05 3.48E−05 2.1731 2.1731 0.7139 0 rs2024902 Imputed A DOMINANT 1.02E−05 1.02E−05 2.3955 2.3955 0.7005 0 rs2025107 Imputed A ADDITIVE 1.24E−05 1.24E−05 2.1211 2.1211 0.6401 0 rs2025107 Imputed A DOMINANT 1.83E−06 1.83E−06 2.4108 2.4108 0.5006 0 rs2025108 Imputed T ADDITIVE 1.24E−05 1.24E−05 2.1211 2.1211 0.6401 0 rs2025108 Imputed T DOMINANT 1.83E−06 1.83E−06 2.4108 2.4108 0.5006 0 rs2062448 Imputed T ADDITIVE 1.78E−05 1.78E−05 0.4975 0.4975 0.4296 0 rs2062448 Imputed T DOMINANT 1.73E−05 1.73E−05 0.4776 0.4776 0.5425 0 rs2063591 Imputed C ADDITIVE 0.001202 0.001202 0.7439 0.7439 0.7716 0 rs2063591 Imputed C DOMINANT 5.22E−05 5.22E−05 0.5704 0.5704 0.86 0 rs2065604 Imputed C DOMINANT 7.75E−05 7.75E−05 0.5093 0.5093 0.7525 0 rs2066238 Imputed T DOMINANT 6.31E−05 6.31E−05 0.5711 0.5711 0.3613 0 rs2068051 Imputed G ADDITIVE 3.45E−05 3.45E−05 0.6225 0.6225 0.8406 0 rs2068051 Imputed G GENOTYPIC 5.01E−05 5.01E−05 0.3895 0.3895 0.8309 0 rs2077702 Genotyped G GENOTYPIC 0.002605 0.002605 1.8705 1.8705 0.3942 0 rs208757 Imputed G ADDITIVE 0.001261 0.001261 1.4776 1.4776 0.5869 0 rs208757 Imputed G DOMINANT 0.0009161 0.0009161 1.5787 1.5787 0.6624 0 rs2095586 Imputed A DOMINANT 0.0001402 0.0004442 1.6153 1.6079 0.2874 11.66 rs2108426 Imputed C DOMINANT 1.31E−05 1.31E−05 0.5744 0.5744 0.799 0 rs2110664 Imputed A DOMINANT 0.0005399 0.0005399 1.568 1.568 0.6563 0 rs2132242 Imputed A DOMINANT 0.0001181 0.0001181 0.6005 0.6005 0.7904 0 rs2151644 Imputed T DOMINANT 7.40E−05 7.40E−05 0.5083 0.5083 0.7589 0 rs2157752 Genotyped A GENOTYPIC 7.96E−05 7.96E−05 0.4178 0.4178 0.6318 0 rs2158958 Imputed A DOMINANT 1.37E−05 1.37E−05 0.5753 0.5753 0.7855 0 rs2158961 Imputed G DOMINANT 1.89E−05 1.89E−05 0.5806 0.5806 0.7575 0 rs2164099 Imputed G ADDITIVE 3.91E−05 3.91E−05 1.51 1.51 0.6597 0 rs2173254 Imputed G GENOTYPIC 4.24E−05 4.24E−05 0.3535 0.3535 0.8105 0 rs2173254 Imputed G RECESSIVE 7.44E−05 7.44E−05 0.3802 0.3802 0.9734 0 rs2188079 Imputed C ADDITIVE 1.42E−05 1.42E−05 1.4883 1.4883 0.9498 0 rs2188079 Imputed C GENOTYPIC 1.20E−05 1.20E−05 2.2697 2.2697 0.9606 0 rs2190304 Imputed G RECESSIVE 2.19E−05 9.93E−05 0.5028 0.5057 0.2831 13.22 rs2190597 Imputed T DOMINANT 0.0009376 0.007487 0.6352 0.6427 0.2354 28.98 rs2190598 Imputed T DOMINANT 1.37E−05 1.37E−05 0.5753 0.5753 0.7855 0 rs2190600 Imputed A DOMINANT 1.57E−05 1.57E−05 0.5759 0.5759 0.7904 0 rs2218084 Imputed T GENOTYPIC 0.0004323 0.0004323 4.066 4.066 0.7112 0 rs2218084 Imputed T RECESSIVE 0.0006382 0.0006382 3.8693 3.8693 0.7945 0 rs2236290 Genotyped C GENOTYPIC 0.001515 0.001515 0.5241 0.5241 0.9756 0 rs2243860 Imputed A GENOTYPIC 0.0002795 0.0002795 2.2455 2.2455 0.9794 0 rs2243860 Imputed A RECESSIVE 0.000191 0.000191 2.1324 2.1324 0.9082 0 rs2246564 Imputed T DOMINANT 7.75E−05 7.75E−05 0.5093 0.5093 0.7525 0 rs2248236 Imputed C DOMINANT 0.00556 0.00556 0.6993 0.6993 0.7827 0 rs2250340 Imputed T DOMINANT 7.34E−05 7.34E−05 0.4999 0.4999 0.8201 0 rs2257192 Imputed G DOMINANT 7.75E−05 7.75E−05 0.5093 0.5093 0.7525 0 rs2270584 Imputed A DOMINANT 2.79E−05 2.79E−05 0.5781 0.5781 0.841 0 rs2270586 Imputed A DOMINANT 2.34E−05 2.34E−05 0.5711 0.5711 0.8905 0 rs2270589 Imputed A ADDITIVE 0.0002129 0.0002129 0.7047 0.7047 0.8921 0 rs2270589 Imputed A DOMINANT 4.02E−06 4.02E−06 0.5172 0.5172 0.475 0 rs2270589 Imputed A GENOTYPIC 0.0008832 0.0008832 0.5338 0.5338 0.9242 0 rs2296889 Imputed C DOMINANT 9.73E−05 9.73E−05 1.7214 1.7214 0.635 0 rs2301346 Imputed C ADDITIVE 1.33E−05 1.33E−05 1.592 1.592 0.8797 0 rs2301346 Imputed C DOMINANT 8.84E−06 8.84E−06 1.8528 1.8528 0.6487 0 rs2327929 Imputed G RECESSIVE 1.47E−05 1.47E−05 1.9741 1.9741 0.5579 0 rs2357486 Imputed C RECESSIVE 9.81E−05 9.81E−05 2.3629 2.3629 0.3237 0 rs2373793 Imputed G DOMINANT 0.0004772 0.0004772 1.624 1.624 0.608 0 rs2377622 Imputed T GENOTYPIC 0.001009 0.001009 0.4327 0.4327 0.9416 0 rs2377622 Imputed T RECESSIVE 0.001315 0.001315 0.4588 0.4588 0.779 0 rs2383903 Imputed G DOMINANT 6.50E−05 6.50E−05 0.6039 0.6039 0.8634 0 rs2389866 Imputed C DOMINANT 0.003524 0.003524 0.6859 0.6859 0.8694 0 rs2389869 Imputed C DOMINANT 0.003524 0.003524 0.6859 0.6859 0.8694 0 rs2418541 Imputed A DOMINANT 1.10E−05 1.10E−05 0.5722 0.5722 0.6924 0 rs2418542 Imputed A DOMINANT 1.10E−05 1.10E−05 0.5722 0.5722 0.6924 0 rs2418548 Imputed C DOMINANT 6.29E−05 6.29E−05 0.5957 0.5957 0.6795 0 rs2476976 Imputed C DOMINANT 0.0002836 0.0002836 1.5809 1.5809 0.3487 0 rs2483639 Imputed A DOMINANT 7.75E−05 7.75E−05 0.5093 0.5093 0.7525 0 rs2483640 Imputed A DOMINANT 7.75E−05 7.75E−05 0.5093 0.5093 0.7525 0 rs2544780 Imputed T RECESSIVE 0.003543 0.003543 1.8115 1.8115 0.7962 0 rs2586458 Imputed T DOMINANT 9.34E−05 9.34E−05 0.471 0.471 0.709 0 rs2593272 Imputed G ADDITIVE 7.80E−05 7.80E−05 0.6664 0.6664 0.4045 0 rs2593273 Imputed T ADDITIVE 5.67E−05 5.67E−05 0.658 0.658 0.4571 0 rs2622499 Imputed G DOMINANT 0.006454 0.006454 0.7042 0.7042 0.7526 0 rs264126 Imputed C DOMINANT 0.0009755 0.0163 0.6364 0.6476 0.1951 40.44 rs264129 Imputed T DOMINANT 1.71E−05 1.71E−05 0.5791 0.5791 0.7456 0 rs2656822 Imputed T ADDITIVE 7.80E−05 7.80E−05 0.6664 0.6664 0.4045 0 rs2656823 Imputed G ADDITIVE 7.80E−05 7.80E−05 0.6664 0.6664 0.4045 0 rs2656825 Imputed T ADDITIVE 7.13E−05 7.13E−05 0.6492 0.6492 0.3189 0 rs2764766 Imputed C RECESSIVE 0.003593 0.003593 1.7939 1.7939 0.9717 0 rs2793101 Imputed T ADDITIVE 6.64E−05 6.64E−05 0.545 0.545 0.5015 0 rs2793101 Imputed T DOMINANT 9.02E−05 9.02E−05 0.5344 0.5344 0.5893 0 rs2795871 Imputed A ADDITIVE 0.0002982 0.0014 0.504 0.4941 0.2612 20.77 rs2795886 Imputed A ADDITIVE 0.0002045 0.0002045 0.4388 0.4388 0.3702 0 rs2795886 Imputed A DOMINANT 0.0003345 0.0003345 0.4401 0.4401 0.3569 0 rs2859994 Imputed C GENOTYPIC 8.11E−05 8.11E−05 2.2234 2.2234 0.9879 0 rs2870464 Imputed G DOMINANT 0.007714 0.007714 1.4837 1.4837 0.7312 0 rs2875528 Imputed T DOMINANT 5.30E−05 8.76E−05 1.9326 1.9381 0.3031 5.72 rs2876227 Imputed C ADDITIVE 0.0003398 0.0003398 1.3941 1.3941 0.991 0 rs2876227 Imputed C GENOTYPIC 0.0005058 0.0005058 1.9894 1.9894 0.6903 0 rs2882097 Imputed A DOMINANT 0.000146 0.000146 1.6135 1.6135 0.3224 0 rs2921983 Imputed C ADDITIVE 3.03E−05 3.03E−05 0.6367 0.6367 0.4592 0 rs2987537 Imputed C DOMINANT 5.27E−05 5.27E−05 0.5308 0.5308 0.6212 0 rs2996416 Imputed C ADDITIVE 6.90E−05 6.90E−05 0.5379 0.5379 0.7323 0 rs2996416 Imputed C DOMINANT 4.54E−05 4.54E−05 0.5019 0.5019 0.6494 0 rs3015527 Imputed C ADDITIVE 8.85E−05 8.85E−05 0.5427 0.5427 0.6864 0 rs3015527 Imputed C DOMINANT 6.15E−05 6.15E−05 0.5073 0.5073 0.6044 0 rs3015530 Imputed C ADDITIVE 6.55E−05 6.55E−05 0.5369 0.5369 0.7455 0 rs3015530 Imputed C DOMINANT 4.31E−05 4.31E−05 0.5009 0.5009 0.6615 0 rs3015531 Imputed T ADDITIVE 6.55E−05 6.55E−05 0.5369 0.5369 0.7455 0 rs3015531 Imputed T DOMINANT 4.31E−05 4.31E−05 0.5009 0.5009 0.6615 0 rs3015535 Imputed C ADDITIVE 6.55E−05 6.55E−05 0.5369 0.5369 0.7455 0 rs3015535 Imputed C DOMINANT 4.31E−05 4.31E−05 0.5009 0.5009 0.6615 0 rs3019407 Imputed A GENOTYPIC 3.61E−05 3.61E−05 0.3507 0.3507 0.848 0 rs3019407 Imputed A RECESSIVE 5.80E−05 5.80E−05 0.3753 0.3753 0.9087 0 rs36071725 Genotyped C GENOTYPIC 2.77E−05 2.77E−05 2.4392 2.4392 0.3383 0 rs373983 Imputed G DOMINANT 0.0002104 0.02216 1.6446 1.5957 0.1398 54.13 rs3756154 Imputed C DOMINANT 0.003524 0.003524 0.6859 0.6859 0.8694 0 rs3793044 Imputed C ADDITIVE 1.34E−05 1.34E−05 2.303 2.303 0.9028 0 rs3793044 Imputed C DOMINANT 5.24E−06 5.24E−06 2.505 2.505 0.845 0 rs3793053 Imputed C ADDITIVE 2.09E−05 2.09E−05 2.0984 2.0984 0.7421 0 rs3793053 Imputed C DOMINANT 4.49E−06 4.49E−06 2.3534 2.3534 0.5617 0 rs3796246 Imputed G ADDITIVE 2.47E−06 6.16E−06 0.4525 0.4504 0.2993 7.17 rs3796246 Imputed G DOMINANT 2.87E−06 2.87E−06 0.4415 0.4415 0.3413 0 rs3805996 Imputed G ADDITIVE 2.67E−05 2.67E−05 2.2289 2.2289 0.7845 0 rs3805996 Imputed G DOMINANT 6.94E−06 6.94E−06 2.4684 2.4684 0.7822 0 rs3806003 Imputed A ADDITIVE 1.34E−05 1.34E−05 2.303 2.303 0.9028 0 rs3806003 Imputed A DOMINANT 5.24E−06 5.24E−06 2.505 2.505 0.845 0 rs3806004 Imputed T ADDITIVE 8.98E−06 8.98E−06 2.1456 2.1456 0.5726 0 rs3806004 Imputed T DOMINANT 1.26E−06 1.26E−06 2.4405 2.4405 0.4411 0 rs3806010 Imputed T ADDITIVE 1.24E−05 1.24E−05 2.1211 2.1211 0.6401 0 rs3806010 Imputed T DOMINANT 1.83E−06 1.83E−06 2.4108 2.4108 0.5006 0 rs3806014 Imputed T ADDITIVE 1.24E−05 1.24E−05 2.1211 2.1211 0.6401 0 rs3806014 Imputed T DOMINANT 1.83E−06 1.83E−06 2.4108 2.4108 0.5006 0 rs3806015 Imputed A ADDITIVE 1.24E−05 1.24E−05 2.1211 2.1211 0.6401 0 rs3806015 Imputed A DOMINANT 1.83E−06 1.83E−06 2.4108 2.4108 0.5006 0 rs3806018 Imputed A ADDITIVE 1.24E−05 1.24E−05 2.1211 2.1211 0.6401 0 rs3806018 Imputed A DOMINANT 1.83E−06 1.83E−06 2.4108 2.4108 0.5006 0 rs3806019 Imputed A ADDITIVE 4.82E−06 4.82E−06 2.2211 2.2211 0.774 0 rs3806019 Imputed A DOMINANT 7.89E−07 7.89E−07 2.5148 2.5148 0.6004 0 rs3806024 Imputed T ADDITIVE 2.13E−05 2.13E−05 2.0967 2.0967 0.7474 0 rs3806024 Imputed T DOMINANT 4.58E−06 4.58E−06 2.3513 2.3513 0.5665 0 rs3847825 Imputed G ADDITIVE 0.0001755 0.0001755 0.7117 0.7117 0.6477 0 rs3847825 Imputed G GENOTYPIC 0.0004069 0.0004069 0.504 0.504 0.39 0 rs3852001 Genotyped C GENOTYPIC 5.01E−05 5.01E−05 3.7361 3.7361 0.4411 0 rs3852001 Genotyped C RECESSIVE 6.81E−05 6.81E−05 3.6068 3.6068 0.5248 0 rs3852002 Imputed G GENOTYPIC 6.98E−05 6.98E−05 3.6551 3.6551 0.4732 0 rs3852002 Imputed G RECESSIVE 9.73E−05 9.73E−05 3.5189 3.5189 0.5652 0 rs3852003 Imputed A GENOTYPIC 6.98E−05 6.98E−05 3.6551 3.6551 0.4732 0 rs3852003 Imputed A RECESSIVE 9.73E−05 9.73E−05 3.5189 3.5189 0.5652 0 rs3942254 Imputed T DOMINANT 0.0001204 0.0001204 0.5984 0.5984 0.9786 0 rs3945085 Imputed A DOMINANT 8.89E−05 8.89E−05 1.637 1.637 0.3315 0 rs399485 Imputed A DOMINANT 0.001889 0.001889 1.4784 1.4784 0.6793 0 rs4029119 Imputed G ADDITIVE 2.71E−05 2.71E−05 0.1993 0.1993 0.5787 0 rs4029119 Imputed G DOMINANT 5.28E−05 5.28E−05 0.203 0.203 0.5644 0 rs412791 Imputed C GENOTYPIC 9.99E−05 9.99E−05 0.4339 0.4339 0.5099 0 rs4146972 Genotyped T DOMINANT 0.003205 0.003205 1.4961 1.4961 0.5773 0 rs4259369 Imputed C RECESSIVE 0.0002939 0.00425 0.557 0.5415 0.2009 38.87 rs4273613 Imputed T ADDITIVE 3.41E−05 3.41E−05 0.2206 0.2206 0.9267 0 rs4273613 Imputed T DOMINANT 6.55E−05 6.55E−05 0.2253 0.2253 0.9509 0 rs4294022 Imputed C DOMINANT 8.50E−05 8.50E−05 0.6007 0.6007 0.6113 0 rs4310554 Genotyped C DOMINANT 0.0005487 0.0005487 1.6987 1.6987 0.7993 0 rs4315598 Imputed T ADDITIVE 0.0005594 0.0005594 1.3676 1.3676 0.7519 0 rs4315598 Imputed T GENOTYPIC 0.0006963 0.0006963 1.9242 1.9242 0.8583 0 rs4370878 Imputed G DOMINANT 0.0001382 0.0001382 1.6143 1.6143 0.3748 0 rs4436200 Imputed C ADDITIVE 0.00342 0.00342 0.6695 0.6695 0.4811 0 rs4444612 Imputed G ADDITIVE 0.0005045 0.0005045 1.3708 1.3708 0.7263 0 rs4444612 Imputed G GENOTYPIC 0.0006517 0.0006517 1.9308 1.9308 0.8764 0 rs4450660 Imputed C DOMINANT 5.07E−05 5.07E−05 1.6768 1.6768 0.885 0 rs4463950 Imputed C DOMINANT 9.57E−05 9.57E−05 0.5933 0.5933 0.705 0 rs4509702 Imputed C DOMINANT 0.0001382 0.0001382 1.6143 1.6143 0.3748 0 rs4533379 Imputed G ADDITIVE 3.75E−05 3.75E−05 1.5121 1.5121 0.6724 0 rs4569984 Imputed A DOMINANT 7.78E−05 7.78E−05 0.5998 0.5998 0.4464 0 rs4570530 Imputed C DOMINANT 0.0001225 0.0001225 1.6207 1.6207 0.3622 0 rs4571583 Imputed T DOMINANT 9.79E−05 9.79E−05 0.6041 0.6041 0.5 0 rs4586678 Imputed A DOMINANT 6.09E−05 6.09E−05 1.6655 1.6655 0.8543 0 rs4615971 Imputed C DOMINANT 0.0001283 0.0006247 1.6223 1.612 0.275 16.09 rs4629229 Imputed G DOMINANT 6.31E−05 6.31E−05 0.5711 0.5711 0.3613 0 rs4632512 Imputed T GENOTYPIC 9.78E−05 9.78E−05 3.572 3.572 0.5084 0 rs4641552 Imputed A ADDITIVE 0.0002608 0.0002608 0.5241 0.5241 0.9002 0 rs4682527 Imputed C DOMINANT 8.72E−05 8.72E−05 1.6904 1.6904 0.7615 0 rs4688632 Imputed G RECESSIVE 0.0003309 0.0003309 0.5825 0.5825 0.5195 0 rs4702720 Imputed A ADDITIVE 0.0001627 0.0001627 0.6287 0.6287 0.5601 0 rs4702720 Imputed A DOMINANT 0.0004444 0.0004444 0.5961 0.5961 0.3979 0 rs4714484 Imputed A ADDITIVE 6.98E−05 6.98E−05 0.6183 0.6183 0.8333 0 rs4714484 Imputed A DOMINANT 5.02E−05 5.02E−05 0.5696 0.5696 0.55 0 rs4725142 Genotyped G RECESSIVE 7.87E−05 7.87E−05 0.4243 0.4243 0.7642 0 rs4725144 Imputed G RECESSIVE 6.02E−05 6.02E−05 0.4125 0.4125 0.8332 0 rs4760785 Imputed A ADDITIVE 0.0006364 0.0006364 0.728 0.728 0.7009 0 rs4760785 Imputed A DOMINANT 0.0001126 0.0001126 0.5881 0.5881 0.915 0 rs4760894 Imputed T ADDITIVE 0.0006364 0.0006364 0.728 0.728 0.7009 0 rs4760894 Imputed T DOMINANT 0.0001126 0.0001126 0.5881 0.5881 0.915 0 rs4760895 Imputed A ADDITIVE 0.0006364 0.0006364 0.728 0.728 0.7009 0 rs4760895 Imputed A DOMINANT 0.0001126 0.0001126 0.5881 0.5881 0.915 0 rs4767184 Imputed C ADDITIVE 0.0002343 0.0002343 0.7168 0.7168 0.7754 0 rs4767184 Imputed C GENOTYPIC 0.0008747 0.0008747 0.5298 0.5298 0.5351 0 rs4773487 Imputed T ADDITIVE 9.48E−05 9.48E−05 0.5543 0.5543 0.9938 0 rs4780547 Imputed G GENOTYPIC 0.002606 0.002606 0.3778 0.3778 0.4518 0 rs4780547 Imputed G RECESSIVE 0.002641 0.002641 0.3832 0.3832 0.5083 0 rs483159 Imputed T DOMINANT 0.001618 0.01337 1.5311 1.5114 0.2239 32.38 rs4836502 Imputed T DOMINANT 1.37E−05 1.37E−05 0.5753 0.5753 0.7855 0 rs4836507 Imputed C DOMINANT 1.68E−05 1.68E−05 0.5765 0.5765 0.7813 0 rs4851531 Imputed T DOMINANT 0.00133 0.00133 0.6585 0.6585 0.3468 0 rs4879931 Imputed G ADDITIVE 0.0002697 0.0002697 0.7001 0.7001 0.5714 0 rs489441 Imputed G ADDITIVE 6.35E−05 6.35E−05 1.5268 1.5268 0.8611 0 rs489441 Imputed G DOMINANT 5.90E−05 5.90E−05 1.6921 1.6921 0.6161 0 rs4976276 Imputed T ADDITIVE 8.75E−05 8.75E−05 1.4687 1.4687 0.8689 0 rs4977681 Imputed C RECESSIVE 9.61E−05 9.61E−05 2.314 2.314 0.6823 0 rs4986197 Imputed G ADDITIVE 3.97E−05 3.97E−05 1.5105 1.5105 0.6441 0 rs4986220 Imputed T ADDITIVE 5.91E−05 5.91E−05 1.5005 1.5005 0.7465 0 rs525462 Imputed A GENOTYPIC 0.0007973 0.004961 0.5445 0.5308 0.2306 30.4 rs552006 Imputed G GENOTYPIC 9.06E−05 9.06E−05 2.4662 2.4662 0.4679 0 rs5756669 Imputed C DOMINANT 7.71E−05 7.71E−05 1.7362 1.7362 0.7477 0 rs581905 Imputed T DOMINANT 0.008112 0.008112 1.5819 1.5819 0.4663 0 rs6033138 Imputed C ADDITIVE 0.0005045 0.0005045 1.3708 1.3708 0.7263 0 rs6033138 Imputed C GENOTYPIC 0.0006517 0.0006517 1.9308 1.9308 0.8764 0 rs6040619 Imputed C ADDITIVE 0.000474 0.000474 1.3729 1.3729 0.7285 0 rs6040619 Imputed C GENOTYPIC 0.0005591 0.0005591 1.9442 1.9442 0.9167 0 rs6040625 Imputed T ADDITIVE 0.0003079 0.0003079 1.3859 1.3859 0.7073 0 rs6040625 Imputed T GENOTYPIC 0.000416 0.000416 1.9717 1.9717 0.9604 0 rs6040630 Imputed A ADDITIVE 0.0003026 0.0003026 1.3874 1.3874 0.7384 0 rs6040630 Imputed A GENOTYPIC 0.0004609 0.0004609 1.9676 1.9676 0.9146 0 rs6040633 Imputed A ADDITIVE 0.0003456 0.0003456 1.3823 1.3823 0.78 0 rs6040633 Imputed A GENOTYPIC 0.0005613 0.0005613 1.945 1.945 0.8535 0 rs6040634 Imputed T ADDITIVE 0.00085 0.00085 1.3491 1.3491 0.6301 0 rs6040634 Imputed T GENOTYPIC 0.001411 0.001411 1.8378 1.8378 0.9672 0 rs6040636 Imputed T ADDITIVE 0.0007597 0.0007597 1.3531 1.3531 0.6477 0 rs6040636 Imputed T GENOTYPIC 0.001336 0.001336 1.8436 1.8436 0.9771 0 rs6040638 Imputed C ADDITIVE 0.0005045 0.0005045 1.3708 1.3708 0.7263 0 rs6040638 Imputed C GENOTYPIC 0.0006517 0.0006517 1.9308 1.9308 0.8764 0 rs6040644 Imputed A ADDITIVE 0.0005045 0.0005045 1.3708 1.3708 0.7263 0 rs6040644 Imputed A GENOTYPIC 0.0006517 0.0006517 1.9308 1.9308 0.8764 0 rs6040667 Imputed T ADDITIVE 0.0002261 0.0002261 1.4034 1.4034 0.9253 0 rs6040667 Imputed T GENOTYPIC 0.0003915 0.0003915 2.0113 2.0113 0.742 0 rs6040668 Imputed C ADDITIVE 0.0002261 0.0002261 1.4034 1.4034 0.9253 0 rs6040668 Imputed C GENOTYPIC 0.0003915 0.0003915 2.0113 2.0113 0.742 0 rs6053005 Imputed C DOMINANT 0.00111 0.01291 0.5203 0.5059 0.1794 44.53 rs6054405 Imputed A RECESSIVE 5.03E−05 5.03E−05 2.0846 2.0846 0.5572 0 rs6054427 Genotyped G GENOTYPIC 9.31E−05 9.31E−05 2.1425 2.1425 0.5656 0 rs6075186 Imputed G DOMINANT 6.31E−05 6.31E−05 0.5711 0.5711 0.3613 0 rs608278 Imputed A ADDITIVE 7.01E−05 7.01E−05 0.6797 0.6797 0.6622 0 rs6111540 Imputed A ADDITIVE 8.63E−05 8.63E−05 0.6872 0.6872 0.3404 0 rs6131206 Imputed C ADDITIVE 0.001921 0.001921 1.3434 1.3434 0.4914 0 rs6131208 Imputed T ADDITIVE 0.0002261 0.0002261 1.4034 1.4034 0.9253 0 rs6131208 Imputed T GENOTYPIC 0.0003915 0.0003915 2.0113 2.0113 0.742 0 rs6131919 Imputed G DOMINANT 6.31E−05 6.31E−05 0.5711 0.5711 0.3613 0 rs6134243 Imputed C ADDITIVE 0.0005045 0.0005045 1.3708 1.3708 0.7263 0 rs6134243 Imputed C GENOTYPIC 0.0006517 0.0006517 1.9308 1.9308 0.8764 0 rs6136020 Imputed A DOMINANT 4.47E−05 4.47E−05 0.564 0.564 0.3277 0 rs613799 Imputed C DOMINANT 0.0002168 0.0002168 1.6378 1.6378 0.4057 0 rs644041 Imputed G ADDITIVE 4.10E−05 4.10E−05 1.5491 1.5491 0.9018 0 rs644041 Imputed G DOMINANT 6.67E−05 6.67E−05 1.6947 1.6947 0.6929 0 rs6464377 Imputed C DOMINANT 8.03E−05 8.03E−05 2.035 2.035 0.5161 0 rs6474230 Imputed T DOMINANT 0.0001096 0.0001096 1.6401 1.6401 0.5183 0 rs6476565 Imputed A DOMINANT 7.38E−05 7.38E−05 0.5063 0.5063 0.7702 0 rs6511286 Imputed T ADDITIVE 8.56E−05 8.56E−05 1.4548 1.4548 0.3238 0 rs6541829 Genotyped C RECESSIVE 0.0008971 0.0008971 2.3027 2.3027 0.4111 0 rs6544721 Imputed G DOMINANT 4.51E−05 4.51E−05 1.6786 1.6786 0.7237 0 rs6544728 Imputed T DOMINANT 3.81E−05 3.81E−05 1.6924 1.6924 0.7254 0 rs6565910 Imputed G DOMINANT 6.35E−05 6.35E−05 0.596 0.596 0.7271 0 rs6581985 Imputed G GENOTYPIC 0.0008728 0.0008728 2.1776 2.1776 0.7023 0 rs6581985 Imputed G RECESSIVE 0.0003781 0.0003781 2.2212 2.2212 0.8679 0 rs6685186 Imputed T ADDITIVE 4.04E−05 4.04E−05 1.4552 1.4552 0.5991 0 rs6685186 Imputed T GENOTYPIC 7.87E−05 7.87E−05 2.1208 2.1208 0.5157 0 rs670593 Imputed A RECESSIVE 0.004705 0.004705 0.6026 0.6026 0.9153 0 rs6722640 Imputed T DOMINANT 0.0009277 0.0009277 0.6505 0.6505 0.4929 0 rs6746170 Imputed A DOMINANT 3.13E−05 3.13E−05 1.7022 1.7022 0.7235 0 rs6757316 Imputed A GENOTYPIC 0.0002411 0.0002411 1.9498 1.9498 0.7316 0 rs6805139 Imputed G DOMINANT 0.000179 0.000179 1.7522 1.7522 0.7218 0 rs6808571 Imputed G ADDITIVE 5.06E−05 5.06E−05 1.6529 1.6529 0.3901 0 rs6816479 Imputed A RECESSIVE 8.91E−05 8.91E−05 2.0191 2.0191 0.6804 0 rs6865976 Imputed C DOMINANT 1.69E−05 1.69E−05 0.5245 0.5245 0.8417 0 rs687047 Imputed C ADDITIVE 0.002064 0.002064 0.6519 0.6519 0.6436 0 rs6871041 Imputed G DOMINANT 1.86E−05 1.86E−05 0.571 0.571 0.7023 0 rs688358 Imputed A ADDITIVE 0.001723 0.001723 0.6472 0.6472 0.7547 0 rs6908481 Imputed C RECESSIVE 2.93E−05 2.93E−05 1.9907 1.9907 0.715 0 rs6917224 Imputed A ADDITIVE 8.07E−05 8.07E−05 1.4126 1.4126 0.6894 0 rs6917224 Imputed A GENOTYPIC 6.12E−05 6.12E−05 2.0516 2.0516 0.8021 0 rs6920677 Imputed G DOMINANT 9.74E−05 9.74E−05 0.6022 0.6022 0.3637 0 rs6994498 Imputed G DOMINANT 0.0001214 0.0001214 1.6355 1.6355 0.5075 0 rs6998772 Imputed T DOMINANT 3.05E−05 3.05E−05 2.6244 2.6244 0.9125 0 rs7022281 Imputed C ADDITIVE 0.0008616 0.0008616 0.7327 0.7327 0.9461 0 rs7022281 Imputed C GENOTYPIC 0.0008065 0.0008065 0.5109 0.5109 0.8632 0 rs7022281 Imputed C RECESSIVE 0.003772 0.003772 0.5858 0.5858 0.653 0 rs7043983 Imputed T DOMINANT 7.81E−05 7.81E−05 0.5075 0.5075 0.763 0 rs7077799 Imputed A DOMINANT 0.0001618 0.0002489 1.6085 1.6059 0.3065 4.35 rs7088947 Imputed A ADDITIVE 0.0002561 0.002122 0.5006 0.4865 0.237 28.49 rs7089661 Imputed C DOMINANT 0.0001402 0.0004442 1.6153 1.6079 0.2874 11.66 rs7102072 Imputed A DOMINANT 2.00E−05 2.00E−05 0.5832 0.5832 0.7992 0 rs710832 Genotyped A RECESSIVE 0.0003556 0.0003556 0.3515 0.3515 0.5598 0 rs712531 Imputed A DOMINANT 4.12E−05 4.12E−05 1.7164 1.7164 0.821 0 rs7129817 Imputed T ADDITIVE 8.64E−05 8.64E−05 0.6917 0.6917 0.9871 0 rs7134262 Imputed T GENOTYPIC 0.000667 0.000667 2.0059 2.0059 0.482 0 rs7134262 Imputed T RECESSIVE 1.92E−05 0.0001342 2.2604 2.2418 0.2719 17.17 rs7138300 Imputed C ADDITIVE 0.0006364 0.0006364 0.728 0.728 0.7009 0 rs7138300 Imputed C DOMINANT 0.0001126 0.0001126 0.5881 0.5881 0.915 0 rs722927 Imputed G ADDITIVE 5.34E−05 5.34E−05 0.4718 0.4718 0.7351 0 rs722927 Imputed G DOMINANT 5.76E−05 5.76E−05 0.4589 0.4589 0.8222 0 rs726424 Genotyped G ADDITIVE 0.0002921 0.0002921 0.7216 0.7216 0.7796 0 rs726424 Genotyped G GENOTYPIC 0.0006575 0.0006575 0.5204 0.5204 0.4936 0 rs7295817 Imputed C ADDITIVE 4.33E−05 4.33E−05 0.6912 0.6912 0.586 0 rs7295817 Imputed C GENOTYPIC 6.93E−05 6.93E−05 0.4694 0.4694 0.3851 0 rs7295817 Imputed C RECESSIVE 0.001037 0.01025 0.5648 0.5757 0.2268 31.55 rs7297372 Imputed A ADDITIVE 0.0002771 0.0002771 0.7072 0.7072 0.6868 0 rs7297372 Imputed A GENOTYPIC 0.0002766 0.0002766 0.4963 0.4963 0.7085 0 rs7298255 Imputed A ADDITIVE 0.0006976 0.0006976 0.7332 0.7332 0.8654 0 rs7298255 Imputed A DOMINANT 6.68E−05 6.68E−05 0.5792 0.5792 0.9355 0 rs7305832 Imputed C GENOTYPIC 0.000667 0.000667 2.0059 2.0059 0.482 0 rs7305832 Imputed C RECESSIVE 1.92E−05 0.0001342 2.2604 2.2418 0.2719 17.17 rs737542 Imputed A RECESSIVE 0.0006435 0.0007974 2.3828 2.3899 0.3091 3.32 rs742827 Imputed A ADDITIVE 0.0002216 0.0002216 1.411 1.411 0.9765 0 rs742827 Imputed A GENOTYPIC 0.0004335 0.0004335 2.0079 2.0079 0.73 0 rs7446891 Imputed G DOMINANT 1.34E−05 1.34E−05 0.5737 0.5737 0.819 0 rs7448641 Imputed C ADDITIVE 2.13E−05 2.13E−05 0.1976 0.1976 0.798 0 rs7448641 Imputed C DOMINANT 3.85E−05 3.85E−05 0.2007 0.2007 0.8145 0 rs7460605 Imputed G DOMINANT 0.0004965 0.0004965 1.5998 1.5998 0.8118 0 rs7468898 Imputed T ADDITIVE 4.70E−05 4.70E−05 1.4562 1.4562 0.6548 0 rs7468898 Imputed T GENOTYPIC 5.27E−05 5.27E−05 2.1254 2.1254 0.7376 0 rs7501186 Imputed A DOMINANT 0.009359 0.009359 1.4572 1.4572 0.5108 0 rs755117 Imputed A DOMINANT 8.93E−05 8.93E−05 1.6937 1.6937 0.8341 0 rs7557560 Imputed T GENOTYPIC 1.52E−05 1.52E−05 4.8002 4.8002 0.5006 0 rs7557560 Imputed T RECESSIVE 1.73E−05 1.73E−05 4.6869 4.6869 0.4673 0 rs7562462 Imputed T DOMINANT 3.98E−05 3.98E−05 1.7863 1.7863 0.5531 0 rs757173 Genotyped G DOMINANT 3.67E−05 3.67E−05 0.5903 0.5903 0.3929 0 rs7607447 Imputed T RECESSIVE 0.004354 0.004354 1.9039 1.9039 0.9167 0 rs7639053 Imputed A ADDITIVE 6.32E−05 6.32E−05 1.5389 1.5389 0.7877 0 rs7648163 Imputed C RECESSIVE 4.30E−05 4.30E−05 2.2905 2.2905 0.3422 0 rs7651273 Imputed A GENOTYPIC 7.69E−05 7.69E−05 3.6491 3.6491 0.3606 0 rs7653190 Imputed C ADDITIVE 5.88E−05 5.88E−05 1.5431 1.5431 0.7499 0 rs7653685 Genotyped C DOMINANT 5.30E−05 8.76E−05 1.9326 1.9381 0.3031 5.72 rs7684899 Imputed C DOMINANT 0.005003 0.005003 0.6963 0.6963 0.8023 0 rs7701604 Imputed G ADDITIVE 2.13E−05 2.13E−05 0.1976 0.1976 0.798 0 rs7701604 Imputed G DOMINANT 3.85E−05 3.85E−05 0.2007 0.2007 0.8145 0 rs7703676 Imputed C ADDITIVE 2.13E−05 2.13E−05 0.1976 0.1976 0.798 0 rs7703676 Imputed C DOMINANT 3.85E−05 3.85E−05 0.2007 0.2007 0.8145 0 rs7711358 Imputed A DOMINANT 2.03E−05 2.03E−05 0.5813 0.5813 0.7623 0 rs7713251 Imputed C RECESSIVE 7.07E−05 7.07E−05 2.2563 2.2563 0.6403 0 rs7737608 Imputed G DOMINANT 2.24E−05 2.24E−05 1.7514 1.7514 0.3895 0 rs7755903 Imputed A GENOTYPIC 9.90E−05 9.90E−05 0.4763 0.4763 0.3374 0 rs7762993 Imputed A ADDITIVE 3.64E−05 3.64E−05 1.5999 1.5999 0.3438 0 rs7762993 Imputed A DOMINANT 5.71E−06 5.71E−06 1.8249 1.8249 0.3301 0 rs7767265 Imputed G DOMINANT 1.54E−06 9.09E−05 1.8708 1.8488 0.2364 28.66 rs7769415 Imputed C GENOTYPIC 0.01222 0.01222 1.7102 1.7102 0.8943 0 rs7771264 Imputed T DOMINANT 9.73E−05 9.73E−05 0.6028 0.6028 0.5969 0 rs7795792 Imputed T RECESSIVE 0.0002939 0.00425 0.557 0.5415 0.2009 38.87 rs7806481 Imputed G RECESSIVE 2.19E−05 9.93E−05 0.5028 0.5057 0.2831 13.22 rs7808536 Imputed G DOMINANT 0.0002294 0.00065 1.6124 1.6227 0.2799 14.36 rs7814819 Imputed G ADDITIVE 0.000435 0.000435 2.1517 2.1517 0.4796 0 rs7814819 Imputed G DOMINANT 0.0002065 0.0002065 2.333 2.333 0.5524 0 rs7815952 Imputed T DOMINANT 3.05E−05 3.05E−05 2.6244 2.6244 0.9125 0 rs7834090 Imputed T DOMINANT 3.05E−05 3.05E−05 2.6244 2.6244 0.9125 0 rs7859250 Imputed C DOMINANT 6.27E−05 6.27E−05 0.5033 0.5033 0.7889 0 rs7863577 Genotyped A ADDITIVE 5.37E−05 5.37E−05 0.5145 0.5145 0.5515 0 rs7863577 Genotyped A DOMINANT 8.32E−05 8.32E−05 0.5032 0.5032 0.6829 0 rs7902140 Imputed C ADDITIVE 8.00E−05 8.00E−05 0.6274 0.6274 0.9605 0 rs7921834 Imputed C DOMINANT 0.0001402 0.0004442 1.6153 1.6079 0.2874 11.66 rs7939893 Imputed C ADDITIVE 0.001509 0.001509 0.7466 0.7466 0.4075 0 rs7939893 Imputed C DOMINANT 0.0007741 0.0007741 0.6536 0.6536 0.8293 0 rs7955901 Imputed C ADDITIVE 0.0008458 0.0008458 0.7371 0.7371 0.7791 0 rs7955901 Imputed C DOMINANT 7.14E−05 7.14E−05 0.5799 0.5799 0.9786 0 rs7956274 Imputed T ADDITIVE 0.001224 0.001224 0.7429 0.7429 0.9488 0 rs7956274 Imputed T DOMINANT 0.0001094 0.0001094 0.5876 0.5876 0.8703 0 rs7957932 Imputed G ADDITIVE 0.001498 0.001498 0.7467 0.7467 0.8677 0 rs7957932 Imputed G DOMINANT 5.69E−05 5.69E−05 0.5706 0.5706 0.9859 0 rs7984294 Imputed A DOMINANT 0.00858 0.00858 1.5738 1.5738 0.5291 0 rs7994286 Imputed A ADDITIVE 9.63E−05 9.63E−05 0.549 0.549 0.854 0 rs7994286 Imputed A DOMINANT 7.82E−05 7.82E−05 0.5161 0.5161 0.7893 0 rs8038229 Genotyped A ADDITIVE 0.001259 0.01927 0.7324 0.7157 0.155 50.55 rs8038229 Genotyped A DOMINANT 0.0009849 0.007544 0.6614 0.6497 0.2113 36.01 rs8043336 Imputed C GENOTYPIC 7.96E−05 7.96E−05 0.3958 0.3958 0.4455 0 rs8043336 Imputed C RECESSIVE 8.36E−05 8.36E−05 0.4142 0.4142 0.5943 0 rs8054431 Imputed T DOMINANT 2.45E−05 2.45E−05 1.7571 1.7571 0.4329 0 rs8066502 Imputed T DOMINANT 0.006801 0.006801 0.683 0.683 0.9956 0 rs8068714 Imputed T DOMINANT 0.006941 0.006941 0.6836 0.6836 0.8713 0 rs892575 Imputed T ADDITIVE 5.64E−05 5.64E−05 1.4995 1.4995 0.67 0 rs892583 Imputed G ADDITIVE 5.66E−05 5.66E−05 1.5024 1.5024 0.7396 0 rs915494 Imputed A ADDITIVE 0.0008012 0.008128 1.402 1.3898 0.223 32.66 rs915494 Imputed A DOMINANT 0.0001453 0.01549 1.6314 1.5891 0.1486 52.08 rs917295 Imputed G DOMINANT 1.41E−05 1.41E−05 0.5759 0.5759 0.7897 0 rs922594 Imputed T DOMINANT 0.00224 0.00224 0.6774 0.6774 0.3822 0 rs9301653 Imputed T ADDITIVE 6.55E−05 6.55E−05 0.5369 0.5369 0.7455 0 rs9301653 Imputed T DOMINANT 4.31E−05 4.31E−05 0.5009 0.5009 0.6615 0 rs9309988 Imputed G DOMINANT 5.30E−05 8.76E−05 1.9326 1.9381 0.3031 5.72 rs9309989 Genotyped C DOMINANT 3.87E−05 3.87E−05 1.9491 1.9491 0.3231 0 rs9310221 Imputed A DOMINANT 9.78E−06 3.80E−05 1.86 1.8519 0.2901 10.65 rs9327555 Imputed T DOMINANT 1.37E−05 1.37E−05 0.5753 0.5753 0.7855 0 rs937890 Imputed G DOMINANT 0.005817 0.005817 0.6731 0.6731 0.8017 0 rs9454967 Imputed G ADDITIVE 7.03E−06 7.03E−06 2.1926 2.1926 0.7348 0 rs9454967 Imputed G DOMINANT 1.21E−06 1.21E−06 2.4795 2.4795 0.5648 0 rs9471295 Imputed T DOMINANT 0.002076 0.002076 1.5391 1.5391 0.8556 0 rs9477007 Imputed A ADDITIVE 5.88E−05 5.88E−05 1.429 1.429 0.6453 0 rs9477007 Imputed A GENOTYPIC 5.42E−05 5.42E−05 2.0759 2.0759 0.7341 0 rs9487279 Imputed T DOMINANT 9.53E−05 9.53E−05 0.5948 0.5948 0.7903 0 rs949016 Imputed C ADDITIVE 4.61E−05 4.61E−05 1.5082 1.5082 0.7183 0 rs9555973 Imputed G ADDITIVE 9.09E−05 9.09E−05 0.5479 0.5479 0.8574 0 rs9555973 Imputed G DOMINANT 7.60E−05 7.60E−05 0.5157 0.5157 0.808 0 rs9557510 Imputed G ADDITIVE 0.0001379 0.0001379 1.6102 1.6102 0.9088 0 rs9557510 Imputed G DOMINANT 4.86E−05 4.86E−05 1.7706 1.7706 0.9892 0 rs9560584 Imputed T DOMINANT 8.00E−05 8.00E−05 0.512 0.512 0.7127 0 rs9588770 Imputed T DOMINANT 8.97E−05 8.97E−05 0.5187 0.5187 0.86 0 rs9588848 Imputed C ADDITIVE 6.55E−05 6.55E−05 0.5369 0.5369 0.7455 0 rs9588848 Imputed C DOMINANT 4.31E−05 4.31E−05 0.5009 0.5009 0.6615 0 rs966583 Imputed A ADDITIVE 0.00064 0.00064 0.7272 0.7272 0.9721 0 rs966583 Imputed A DOMINANT 6.94E−05 6.94E−05 0.5916 0.5916 0.8081 0 rs974130 Genotyped A RECESSIVE 9.67E−05 9.67E−05 2.0112 2.0112 0.6677 0 rs977160 Imputed T ADDITIVE 1.90E−05 1.90E−05 1.5465 1.5465 0.3814 0 rs9812206 Imputed G ADDITIVE 1.27E−06 1.27E−06 0.4469 0.4469 0.5437 0 rs9812206 Imputed G DOMINANT 1.72E−06 1.72E−06 0.4369 0.4369 0.61 0 rs9813552 Imputed G ADDITIVE 2.01E−06 2.01E−06 0.4493 0.4493 0.4991 0 rs9813552 Imputed G DOMINANT 2.40E−06 2.40E−06 0.4387 0.4387 0.5642 0 rs9815037 Imputed T ADDITIVE 1.57E−06 1.57E−06 0.4461 0.4461 0.5119 0 rs9815037 Imputed T DOMINANT 1.83E−06 1.83E−06 0.4354 0.4354 0.5792 0 rs9825349 Imputed A ADDITIVE 1.57E−06 1.57E−06 0.4461 0.4461 0.5119 0 rs9825349 Imputed A DOMINANT 1.83E−06 1.83E−06 0.4354 0.4354 0.5792 0 rs9834217 Imputed T ADDITIVE 1.61E−06 1.61E−06 0.4466 0.4466 0.5093 0 rs9834217 Imputed T DOMINANT 1.89E−06 1.89E−06 0.4359 0.4359 0.5761 0 rs9840460 Imputed T ADDITIVE 1.57E−06 1.57E−06 0.4461 0.4461 0.5119 0 rs9840460 Imputed T DOMINANT 1.83E−06 1.83E−06 0.4354 0.4354 0.5792 0 rs9840756 Imputed A ADDITIVE 1.55E−06 1.55E−06 0.4458 0.4458 0.5071 0 rs9840756 Imputed A DOMINANT 1.81E−06 1.81E−06 0.435 0.435 0.5742 0 rs9844801 Imputed C DOMINANT 5.30E−05 8.76E−05 1.9326 1.9381 0.3031 5.72 rs985375 Imputed A GENOTYPIC 6.39E−05 6.39E−05 2.8891 2.8891 0.9861 0 rs9869187 Imputed C ADDITIVE 7.35E−06 7.35E−06 0.4651 0.4651 0.7004 0 rs9869187 Imputed C DOMINANT 2.02E−05 2.02E−05 0.4704 0.4704 0.6809 0 rs9872327 Imputed T DOMINANT 5.30E−05 8.76E−05 1.9326 1.9381 0.3031 5.72 rs9881685 Imputed A ADDITIVE 1.31E−06 1.31E−06 0.4438 0.4438 0.4978 0 rs9881685 Imputed A DOMINANT 1.61E−06 1.61E−06 0.4332 0.4332 0.5585 0 rs9909499 Imputed C DOMINANT 0.002624 0.002624 1.4669 1.4669 0.7269 0 rs9911847 Imputed G DOMINANT 0.00547 0.00547 0.6755 0.6755 0.9212 0 rs9946886 Imputed G RECESSIVE 5.84E−05 5.84E−05 0.3084 0.3084 0.8937 0 rs9958823 Imputed A ADDITIVE 2.61E−05 2.61E−05 1.5292 1.5292 0.6713 0 rs9965248 Imputed T ADDITIVE 6.66E−05 6.66E−05 1.4965 1.4965 0.6122 0

TABLE 13 ALLELE SNP rs # SOURCE (A1) MODEL P P(R) OR OR(R) Q I rs198460 Genotyped G RECESSIVE 2.05E−06 2.05E−06 1.8108 1.8108 0.5587 0 rs603940 Genotyped G RECESSIVE 7.32E−05 7.32E−05 0.5405 0.5405 0.4588 0 rs10021016 Genotyped G GENOTYPIC 5.48E−05 5.48E−05 2.3945 2.3945 0.8903 0 rs1003148 Imputed C ADDITIVE 1.19E−05 1.19E−05 0.7154 0.7154 0.9106 0 rs1003148 Imputed C GENOTYPIC 8.14E−06 8.14E−06 0.4872 0.4872 0.8101 0 rs1003148 Imputed C RECESSIVE 5.89E−05 5.89E−05 0.5541 0.5541 0.5169 0 rs10046799 Imputed C ADDITIVE 8.59E−05 8.59E−05 0.7444 0.7444 0.3859 0 rs10046799 Imputed C GENOTYPIC 6.10E−05 6.10E−05 0.5427 0.5427 0.4931 0 rs10051148 Imputed C DOMINANT 1.16E−06 1.16E−06 0.596 0.596 0.8669 0 rs10054055 Imputed T DOMINANT 4.36E−07 4.36E−07 0.5814 0.5814 0.9471 0 rs10067895 Imputed A DOMINANT 3.37E−07 3.37E−07 0.5762 0.5762 0.9653 0 rs1008705 Imputed C DOMINANT 9.36E−05 9.36E−05 1.6202 1.6202 0.516 0 rs10105871 Imputed C DOMINANT 9.54E−05 9.54E−05 1.5752 1.5752 0.7598 0 rs10116807 Imputed A GENOTYPIC 2.35E−05 2.35E−05 3.1548 3.1548 0.994 0 rs10116807 Imputed A RECESSIVE 4.72E−05 4.72E−05 2.9802 2.9802 0.9943 0 rs10121941 Imputed C DOMINANT 3.10E−03 1.47E−01 0.6558 0.6652 0.0252 72.84 rs10128638 Genotyped G DOMINANT 7.89E−05 7.89E−05 0.6196 0.6196 0.8513 0 rs1012924 Imputed G ADDITIVE 6.22E−02 5.77E−01 0.7882 0.8017 0.0001 89.23 rs1012924 Imputed G DOMINANT 6.06E−02 0.5529 0.7739 0.7744 0.0001 89.62 rs1016030 Genotyped G ADDITIVE 9.82E−05 9.82E−05 1.3592 1.3592 0.3844 0 rs1016030 Genotyped G GENOTYPIC 0.0001503 0.0001808 1.8631 1.8624 0.3605 1.98 rs1017558 Imputed A RECESSIVE 3.63E−03 0.1741 1.5611 1.5084 0.0227 73.6 rs10183431 Imputed T DOMINANT 1.18E−04 0.0001179 1.5094 1.5094 0.452 0 rs10195401 Imputed C DOMINANT 5.75E−04 0.01653 1.4645 1.4526 0.1484 47.59 rs10239416 Imputed A DOMINANT 8.79E−03 0.3403 0.7512 0.7725 0.0026 83.15 rs1032188 Imputed G GENOTYPIC 3.23E−05 3.23E−05 0.415 0.415 0.4549 0 rs1032188 Imputed G RECESSIVE 4.57E−05 4.57E−05 0.4331 0.4331 0.3757 0 rs10468988 Imputed G ADDITIVE 1.19E−04 0.005354 1.3915 1.3736 0.1822 41.27 rs10478919 Imputed G DOMINANT 3.36E−07 3.36E−07 0.5781 0.5781 0.9145 0 rs10506623 Imputed C DOMINANT 4.11E−05 4.11E−05 0.6355 0.6355 0.7566 0 rs10506626 Imputed A DOMINANT 4.77E−06 4.77E−06 0.6029 0.6029 0.7652 0 rs10509477 Imputed T DOMINANT 5.09E−05 5.09E−05 1.5361 1.5361 0.4725 0 rs10511071 Imputed C DOMINANT 0.003653 0.1786 1.4802 1.4969 0.0084 79.08 rs10511072 Imputed G DOMINANT 3.65E−03 1.79E−01 1.4802 1.4969 0.0084 79.08 rs10511199 Imputed C ADDITIVE 9.12E−04 2.82E−02 1.348 1.3411 0.1188 53.05 rs10513283 Imputed G GENOTYPIC 3.27E−04 1.14E−02 2.7233 2.5889 0.1701 43.55 rs10520072 Imputed T DOMINANT 4.33E−07 4.33E−07 0.5808 0.5808 0.9574 0 rs1065639 Imputed C DOMINANT 5.13E−05 5.13E−05 1.7169 1.7169 0.8785 0 rs10733846 Imputed G ADDITIVE 1.71E−05 5.53E−04 0.6464 0.6552 0.2454 28.81 rs10733846 Imputed G DOMINANT 5.14E−05 5.14E−05 0.6265 0.6265 0.543 0 rs10737390 Imputed T DOMINANT 1.70E−03 0.1499 0.7059 0.7364 0.0305 71.34 rs10749293 Imputed G DOMINANT 1.78E−05 1.78E−05 1.5736 1.5736 0.524 0 rs10752159 Imputed G DOMINANT 7.32E−05 7.32E−05 1.5394 1.5394 0.5089 0 rs10753760 Imputed T ADDITIVE 3.60E−03 0.1365 1.2495 1.2446 0.0275 72.17 rs10753760 Imputed T GENOTYPIC 3.73E−03 0.1448 1.579 1.5661 0.0247 72.99 rs10757887 Imputed C DOMINANT 2.10E−03 0.09341 0.7185 0.7262 0.048 67.07 rs10758326 Imputed A ADDITIVE 3.12E−05 3.12E−05 0.7205 0.7205 0.9344 0 rs10758326 Imputed A GENOTYPIC 1.46E−05 1.46E−05 0.4748 0.4748 0.6437 0 rs10758326 Imputed A RECESSIVE 9.28E−05 9.28E−05 0.5372 0.5372 0.3903 0 rs10762236 Genotyped G ADDITIVE 1.41E−04 1.36E−02 0.6866 0.7015 0.1342 50.22 rs10765769 Imputed C ADDITIVE 1.89E−05 1.89E−05 1.3977 1.3977 0.5396 0 rs10765769 Imputed C GENOTYPIC 4.04E−05 4.04E−05 1.9329 1.9329 0.5283 0 rs10784891 Imputed C ADDITIVE 3.30E−05 3.30E−05 0.7221 0.7221 0.8883 0 rs10784891 Imputed C DOMINANT 3.17E−05 3.17E−05 0.6171 0.6171 0.6062 0 rs10787923 Imputed G DOMINANT 1.17E−05 1.17E−05 1.5929 1.5929 0.4856 0 rs10787949 Imputed A DOMINANT 6.84E−05 6.84E−05 1.5282 1.5282 0.4028 0 rs10787951 Imputed G DOMINANT 7.02E−05 7.02E−05 1.5272 1.5272 0.4 0 rs10787983 Imputed C DOMINANT 5.52E−05 5.52E−05 1.5334 1.5334 0.4235 0 rs10788380 Imputed C ADDITIVE 7.51E−05 7.51E−05 1.3528 1.3528 0.8856 0 rs10788380 Imputed C DOMINANT 3.53E−05 3.53E−05 1.6982 1.6982 0.9632 0 rs10788380 Imputed C GENOTYPIC 6.34E−05 6.34E−05 1.8532 1.8532 0.9102 0 rs10814418 Imputed G DOMINANT 3.49E−03 1.53E−01 0.6592 0.6683 0.0249 72.93 rs10831417 Imputed A ADDITIVE 3.85E−05 3.11E−04 1.3868 1.3856 0.2831 20.76 rs10831417 Imputed A GENOTYPIC 4.55E−05 6.53E−04 1.9715 1.9609 0.2571 26.37 rs10831422 Imputed C ADDITIVE 8.06E−05 8.06E−05 1.366 1.366 0.4125 0 rs10831422 Imputed C GENOTYPIC 6.96E−05 6.96E−05 1.9315 1.9315 0.3829 0 rs10862931 Imputed C GENOTYPIC 5.74E−02 0.5627 0.7112 0.7348 0.0002 88.45 rs10865197 Imputed C DOMINANT 1.16E−04 0.0001158 1.5096 1.5096 0.4518 0 rs10871302 Imputed A DOMINANT 1.00E−04 0.0001 1.6031 1.6031 0.379 0 rs10877463 Imputed C DOMINANT 6.35E−05 6.35E−05 0.6518 0.6518 0.5839 0 rs10877468 Imputed C DOMINANT 7.07E−05 7.07E−05 0.653 0.653 0.5247 0 rs10879240 Imputed C ADDITIVE 3.80E−05 3.80E−05 0.6993 0.6993 0.5299 0 rs10879242 Imputed A DOMINANT 1.18E−05 1.18E−05 0.6 0.6 0.4258 0 rs10879245 Imputed G DOMINANT 1.18E−05 1.18E−05 0.6 0.6 0.4258 0 rs10879249 Imputed T DOMINANT 4.34E−05 4.34E−05 0.6359 0.6359 0.7079 0 rs10886452 Imputed A DOMINANT 5.56E−05 5.56E−05 1.5358 1.5358 0.4242 0 rs10886463 Imputed C DOMINANT 6.07E−05 6.07E−05 1.533 1.533 0.4181 0 rs10886465 Imputed A DOMINANT 7.14E−05 7.14E−05 1.5271 1.5271 0.4344 0 rs10886526 Imputed C DOMINANT 6.05E−05 6.05E−05 1.5311 1.5311 0.4839 0 rs10902437 Imputed G ADDITIVE 6.85E−05 6.85E−05 1.3724 1.3724 0.531 0 rs10941126 Imputed G ADDITIVE 8.37E−03 1.24E−01 0.5451 0.3771 0.0037 82.12 rs10941126 Imputed G DOMINANT 1.51E−02 1.69E−01 0.5356 0.3959 0.0036 82.2 rs10947871 Imputed A DOMINANT 2.83E−05 2.83E−05 1.6668 1.6668 0.5021 0 rs10972978 Imputed G DOMINANT 4.09E−03 0.1884 0.6606 0.6715 0.0152 76.11 rs10973012 Imputed A DOMINANT 3.10E−03 0.1472 0.6558 0.6652 0.0252 72.84 rs10974028 Genotyped G ADDITIVE 6.17E−03 2.38E−01 0.7519 0.7698 0.0127 77.08 rs10974028 Genotyped G DOMINANT 1.85E−03 2.16E−01 0.6916 0.7096 0.0051 81.08 rs11021302 Imputed A ADDITIVE 9.21E−05 9.21E−05 1.3623 1.3623 0.4193 0 rs11021302 Imputed A GENOTYPIC 7.34E−05 7.34E−05 1.9274 1.9274 0.3854 0 rs11099644 Imputed G RECESSIVE 3.63E−03 1.74E−01 1.5611 1.5084 0.0227 73.6 rs11138315 Imputed G ADDITIVE 5.97E−05 5.97E−05 0.6045 0.6045 0.6837 0 rs11149802 Imputed T DOMINANT 1.00E−04 1.00E−04 1.6031 1.6031 0.379 0 rs1116596 Imputed T DOMINANT 3.36E−07 3.36E−07 0.5781 0.5781 0.9145 0 rs11178531 Imputed A ADDITIVE 5.04E−05 5.04E−05 0.7345 0.7345 0.9113 0 rs11178531 Imputed A DOMINANT 1.62E−05 1.62E−05 0.6062 0.6062 0.7273 0 rs11178575 Imputed C GENOTYPIC 7.77E−05 7.77E−05 2.0518 2.0518 0.4613 0 rs11178575 Imputed C RECESSIVE 8.55E−05 8.55E−05 1.9633 1.9633 0.6307 0 rs11178577 Imputed T GENOTYPIC 8.19E−05 8.19E−05 2.0467 2.0467 0.4668 0 rs11178577 Imputed T RECESSIVE 8.45E−05 8.45E−05 1.9643 1.9643 0.6423 0 rs11178583 Imputed A DOMINANT 3.48E−05 3.48E−05 0.6311 0.6311 0.6157 0 rs11178589 Imputed T DOMINANT 6.58E−05 6.58E−05 0.6416 0.6416 0.759 0 rs11178594 Imputed C DOMINANT 2.21E−05 2.21E−05 0.6259 0.6259 0.7529 0 rs11178602 Imputed T DOMINANT 1.96E−05 1.96E−05 0.6239 0.6239 0.7278 0 rs11178648 Imputed T DOMINANT 4.60E−06 4.60E−06 0.6044 0.6044 0.7746 0 rs11198877 Imputed T DOMINANT 5.89E−05 5.89E−05 1.5335 1.5335 0.418 0 rs11198942 Imputed T DOMINANT 4.04E−05 4.04E−05 1.5455 1.5455 0.4358 0 rs11221075 Imputed A ADDITIVE 4.74E−05 4.74E−05 0.6113 0.6113 0.5392 0 rs11242020 Imputed T DOMINANT 2.55E−07 2.55E−07 0.5746 0.5746 0.9225 0 rs11242021 Imputed T DOMINANT 4.26E−07 4.26E−07 0.5804 0.5804 0.9558 0 rs11242022 Imputed T DOMINANT 5.79E−07 5.79E−07 0.5841 0.5841 0.9318 0 rs11242023 Imputed T DOMINANT 5.92E−07 5.92E−07 0.5843 0.5843 0.9496 0 rs1149350 Imputed A DOMINANT 2.45E−03 1.30E−01 1.3997 1.3907 0.0257 72.68 rs1150143 Imputed G DOMINANT 6.34E−04 3.31E−02 1.4503 1.4366 0.0937 57.77 rs11576627 Imputed T ADDITIVE 4.22E−05 4.22E−05 1.5665 1.5665 0.6281 0 rs11576627 Imputed T DOMINANT 3.05E−05 3.05E−05 1.6676 1.6676 0.7461 0 rs11602189 Imputed A DOMINANT 1.82E−04 0.001317 0.6717 0.6744 0.2718 23.24 rs11605163 Imputed A DOMINANT 0.000708 0.02749 1.6562 1.6712 0.0948 57.56 rs11615214 Imputed G ADDITIVE 5.75E−06 5.75E−06 0.7047 0.7047 0.5765 0 rs11615214 Imputed G GENOTYPIC 2.91E−06 2.91E−06 0.4566 0.4566 0.4781 0 rs11642394 Imputed C DOMINANT 9.69E−05 9.69E−05 1.6046 1.6046 0.3847 0 rs11644943 Imputed A ADDITIVE 6.34E−05 6.34E−05 1.4362 1.4362 0.687 0 rs11656608 Imputed T DOMINANT 5.19E−05 5.19E−05 0.6191 0.6191 0.5685 0 rs11661309 Imputed A ADDITIVE 3.44E−05 3.44E−05 0.6656 0.6656 0.471 0 rs11661309 Imputed A DOMINANT 2.13E−04 8.96E−04 0.6556 0.657 0.2991 17.16 rs11666131 Imputed A ADDITIVE 3.25E−04 6.19E−03 1.3849 1.3772 0.1964 38.55 rs11743355 Imputed C ADDITIVE 1.07E−02 1.27E−01 0.5495 0.3573 0.0028 82.99 rs11743355 Imputed C DOMINANT 1.87E−02 1.70E−01 0.5389 0.3746 0.0027 83.11 rs11746806 Imputed T ADDITIVE 8.22E−03 0.1202 0.5498 0.3996 0.0061 80.4 rs11746806 Imputed T DOMINANT 1.56E−02 1.68E−01 0.5436 0.4204 0.006 80.44 rs11746959 Imputed T ADDITIVE 8.37E−03 1.24E−01 0.5451 0.3771 0.0037 82.12 rs11746959 Imputed T DOMINANT 1.51E−02 1.69E−01 0.5356 0.3959 0.0036 82.2 rs11749272 Imputed T DOMINANT 3.75E−07 3.75E−07 0.5789 0.5789 0.9197 0 rs11901899 Imputed A DOMINANT 5.05E−05 5.05E−05 1.5436 1.5436 0.6491 0 rs11926319 Imputed G ADDITIVE 2.62E−05 3.51E−02 0.5502 0.5519 0.0242 73.13 rs11926319 Imputed G DOMINANT 4.50E−05 0.04527 0.5488 0.5505 0.0199 74.48 rs11956952 Imputed C DOMINANT 8.97E−05 8.97E−05 0.6544 0.6544 0.9288 0 rs12025826 Imputed G DOMINANT 9.61E−05 9.61E−05 1.5444 1.5444 0.6337 0 rs1204522 Imputed C GENOTYPIC 1.76E−03 0.09323 0.5754 0.5955 0.0532 65.92 rs1204524 Imputed A GENOTYPIC 1.75E−03 0.09548 0.5752 0.5962 0.0519 66.2 rs12153185 Imputed T DOMINANT 3.02E−07 3.02E−07 0.575 0.575 0.965 0 rs12182651 Imputed T ADDITIVE 4.03E−04 6.63E−02 1.6379 1.6775 0.0204 74.32 rs12182651 Imputed T DOMINANT 9.90E−05 0.06125 1.8091 1.8433 0.0126 77.13 rs12193568 Imputed G DOMINANT 5.33E−05 5.33E−05 1.7043 1.7043 0.4515 0 rs12264914 Imputed C DOMINANT 9.89E−05 9.89E−05 0.5796 0.5796 0.4664 0 rs12307767 Imputed C DOMINANT 7.20E−05 7.20E−05 0.6476 0.6476 0.5868 0 rs1232298 Imputed G RECESSIVE 4.05E−05 4.05E−05 2.0359 2.0359 0.4524 0 rs12407412 Imputed C ADDITIVE 4.22E−05 4.22E−05 1.5665 1.5665 0.6281 0 rs12407412 Imputed C DOMINANT 3.05E−05 3.05E−05 1.6676 1.6676 0.7461 0 rs12420184 Imputed G DOMINANT 1.51E−02 0.4077 0.7481 0.7745 0.0016 84.53 rs12422750 Imputed A DOMINANT 9.60E−05 9.60E−05 0.6598 0.6598 0.5137 0 rs12446951 Imputed A ADDITIVE 3.93E−05 1.09E−04 2.0253 2.0349 0.3226 11.62 rs12446951 Imputed A DOMINANT 4.82E−05 4.82E−05 2.049 2.049 0.3973 0 rs12457400 Imputed G DOMINANT 7.89E−05 7.89E−05 0.5854 0.5854 0.8723 0 rs1247340 Imputed C DOMINANT 2.05E−03 0.1157 1.4086 1.4002 0.0296 71.6 rs1247341 Imputed C DOMINANT 1.57E−03 1.02E−01 1.4213 1.4156 0.0312 71.17 rs12521291 Imputed G ADDITIVE 1.87E−03 1.09E−01 0.7805 0.7921 0.04 68.92 rs12526849 Imputed T ADDITIVE 7.17E−04 0.03214 1.2878 1.2722 0.1105 54.59 rs12526849 Imputed T GENOTYPIC 3.38E−04 5.04E−03 1.7306 1.7075 0.2173 34.49 rs12543110 Imputed G DOMINANT 5.89E−05 5.89E−05 1.5358 1.5358 0.5248 0 rs12678600 Imputed A DOMINANT 1.00E−04 1.00E−04 0.6602 0.6602 0.5151 0 rs12719415 Imputed T DOMINANT 2.53E−07 2.53E−07 0.5739 0.5739 0.9166 0 rs12831292 Imputed G DOMINANT 2.63E−05 2.63E−05 0.6278 0.6278 0.7312 0 rs12923993 Imputed C DOMINANT 9.69E−05 9.69E−05 1.6046 1.6046 0.3847 0 rs12936964 Imputed T DOMINANT 3.11E−04 2.93E−03 1.4884 1.4756 0.2539 27.04 rs12960663 Imputed G ADDITIVE 4.89E−05 4.89E−05 0.6695 0.6695 0.515 0 rs13038146 Imputed C ADDITIVE 3.11E−05 3.11E−05 1.376 1.376 0.9378 0 rs13038146 Imputed C GENOTYPIC 2.11E−05 2.11E−05 2.0071 2.0071 0.9192 0 rs13134222 Imputed A GENOTYPIC 1.96E−02 3.26E−01 0.5583 0.5463 0.0028 82.95 rs13172910 Imputed A DOMINANT 7.00E−05 7.00E−05 0.6505 0.6505 0.9366 0 rs13194907 Imputed A ADDITIVE 0.0002176 0.02467 1.7666 1.7835 0.0668 63.04 rs13194907 Imputed A DOMINANT 6.05E−05 0.01168 1.9281 1.9369 0.0827 59.88 rs13195745 Imputed A ADDITIVE 2.18E−04 2.47E−02 1.7666 1.7835 0.0668 63.04 rs13195745 Imputed A DOMINANT 6.05E−05 1.17E−02 1.9281 1.9369 0.0827 59.88 rs1321432 Imputed A RECESSIVE 8.48E−04 0.08213 1.6508 1.6057 0.0423 68.39 rs1321457 Imputed G RECESSIVE 0.001376 0.1001 1.6314 1.5668 0.0465 67.4 rs13265054 Imputed T DOMINANT 6.52E−05 6.52E−05 0.6518 0.6518 0.6806 0 rs13282131 Imputed C GENOTYPIC 6.27E−05 6.27E−05 1.8345 1.8345 0.9895 0 rs13353526 Imputed C DOMINANT 0.004081 0.1849 1.4667 1.4829 0.0079 79.32 rs1336382 Imputed T DOMINANT 5.09E−05 5.09E−05 1.5361 1.5361 0.4725 0 rs1336383 Imputed T DOMINANT 5.09E−05 5.09E−05 1.5361 1.5361 0.4725 0 rs1336407 Imputed T DOMINANT 5.93E−05 5.93E−05 1.5308 1.5308 0.4544 0 rs1336409 Imputed T DOMINANT 6.50E−05 6.50E−05 1.5274 1.5274 0.444 0 rs1336596 Imputed A DOMINANT 5.26E−04 3.65E−02 0.6858 0.7027 0.0985 56.85 rs1343560 Imputed T ADDITIVE 6.41E−02 5.75E−01 0.7895 0.8024 0.0001 89.05 rs1343560 Imputed T DOMINANT 6.21E−02 5.51E−01 0.775 0.7751 0.0001 89.44 rs1361987 Imputed T GENOTYPIC 2.87E−03 1.52E−01 0.5945 0.6201 0.0307 71.3 rs1386153 Imputed T ADDITIVE 0.0001163 0.0001163 0.7313 0.7313 0.4314 0 rs1386153 Imputed T DOMINANT 0.0001226 0.0004692 0.6655 0.6672 0.3089 14.88 rs1394015 Imputed C DOMINANT 4.04E−05 4.04E−05 1.7398 1.7398 0.8288 0 rs1407038 Imputed A RECESSIVE 1.15E−03 0.09526 1.6392 1.5778 0.0445 67.86 rs1407039 Imputed A RECESSIVE 1.54E−03 0.08002 1.6009 1.5561 0.0626 63.92 rs1412802 Imputed T GENOTYPIC 9.49E−05 9.49E−05 0.4269 0.4269 0.9393 0 rs1414865 Imputed T DOMINANT 6.84E−05 6.84E−05 1.5282 1.5282 0.4028 0 rs1414873 Imputed A DOMINANT 5.05E−05 5.05E−05 1.5365 1.5365 0.433 0 rs1414876 Imputed C DOMINANT 5.05E−05 5.05E−05 1.5365 1.5365 0.433 0 rs1418671 Imputed C RECESSIVE 8.77E−05 1.17E−02 1.79 1.752 0.1097 54.76 rs1419490 Genotyped T GENOTYPIC 1.69E−03 1.04E−01 0.5757 0.6036 0.051 66.41 rs1434507 Imputed A ADDITIVE 3.80E−04 1.15E−02 1.3574 1.3388 0.175 42.63 rs1434508 Imputed T ADDITIVE 4.60E−04 1.09E−02 1.3515 1.3341 0.1863 40.49 rs1435205 Imputed A ADDITIVE 9.12E−04 2.82E−02 1.348 1.3411 0.1188 53.05 rs1443928 Imputed C RECESSIVE 9.45E−04 4.30E−02 0.6717 0.6702 0.0739 61.62 rs1452235 Imputed G GENOTYPIC 5.06E−02 5.71E−01 0.7054 0.7381 0.0001 88.72 rs1452236 Imputed G GENOTYPIC 4.94E−02 5.70E−01 0.7041 0.7369 0.0001 88.77 rs1452237 Imputed G GENOTYPIC 5.06E−02 5.71E−01 0.7054 0.7381 0.0001 88.72 rs1452243 Genotyped T GENOTYPIC 5.39E−02 5.77E−01 0.7092 0.7402 0.0001 88.89 rs1463768 Genotyped G RECESSIVE 2.87E−05 3.63E−05 1.813 1.8163 0.3578 2.71 rs1463769 Imputed G RECESSIVE 2.08E−05 2.08E−05 1.8336 1.8336 0.3916 0 rs1472435 Imputed A ADDITIVE 4.20E−05 4.20E−05 0.5101 0.5101 0.5038 0 rs1472435 Imputed A DOMINANT 8.16E−05 8.16E−05 0.5146 0.5146 0.4725 0 rs1476714 Imputed A DOMINANT 3.69E−07 3.69E−07 0.5781 0.5781 0.9536 0 rs1495159 Imputed G ADDITIVE 0.009749 0.3924 0.8068 0.8189 0.0005 86.97 rs1495159 Imputed G GENOTYPIC 3.08E−03 1.34E−01 0.5615 0.5708 0.0278 72.1 rs1495375 Imputed A DOMINANT 3.20E−05 3.20E−05 0.6273 0.6273 0.709 0 rs1495376 Imputed T DOMINANT 2.76E−05 3.75E−04 0.5966 0.5952 0.2528 27.28 rs1495377 Imputed G DOMINANT 5.28E−05 0.0006669 0.6086 0.6065 0.2463 28.63 rs1495381 Imputed T GENOTYPIC 1.97E−05 1.97E−05 1.9868 1.9868 0.6544 0 rs1495381 Imputed T RECESSIVE 3.14E−06 3.14E−06 1.9704 1.9704 0.904 0 rs1498992 Imputed G DOMINANT 4.91E−05 4.91E−05 0.6496 0.6496 0.6335 0 rs1499001 Imputed T DOMINANT 9.99E−05 9.99E−05 0.6588 0.6588 0.5929 0 rs1512988 Imputed A DOMINANT 3.15E−05 3.15E−05 0.6309 0.6309 0.7406 0 rs1512989 Imputed T DOMINANT 3.15E−05 3.15E−05 0.6309 0.6309 0.7406 0 rs1512991 Imputed T ADDITIVE 4.36E−05 4.36E−05 0.7304 0.7304 0.9674 0 rs1512991 Imputed T DOMINANT 2.35E−05 2.35E−05 0.6133 0.6133 0.7725 0 rs1516855 Imputed G RECESSIVE 2.16E−04 3.15E−03 1.8266 1.832 0.214 35.15 rs1527450 Imputed T ADDITIVE 4.98E−05 0.0004174 1.3805 1.3796 0.2782 21.84 rs1527450 Imputed T GENOTYPIC 5.39E−05 0.0005959 1.9591 1.9507 0.2671 24.24 rs1567740 Imputed T DOMINANT 3.10E−05 3.10E−05 0.6303 0.6303 0.7208 0 rs1572573 Imputed A ADDITIVE 2.29E−04 0.04251 1.4476 1.3911 0.0856 59.31 rs1572573 Imputed A DOMINANT 9.40E−05 4.64E−02 1.562 1.5083 0.0429 68.24 rs1584003 Imputed C DOMINANT 3.34E−02 0.561 1.2949 1.2466 0.0001 89.29 rs1584005 Imputed C DOMINANT 4.02E−02 5.68E−01 1.2838 1.2385 0.0001 89 rs1585771 Imputed G ADDITIVE 1.04E−03 0.04355 1.3199 1.3042 0.0982 56.91 rs1592015 Imputed G DOMINANT 0.002751 0.1964 0.7042 0.7334 0.018 75.11 rs1594885 Imputed A ADDITIVE 0.000164 0.004814 1.3801 1.3638 0.201 37.68 rs1603232 Imputed A DOMINANT 6.82E−05 7.72E−05 0.6125 0.6124 0.3627 1.4 rs1614565 Imputed C DOMINANT 1.67E−05 2.91E−05 0.5932 0.5932 0.3482 5.22 rs1648200 Imputed G ADDITIVE 9.92E−05 9.92E−05 1.428 1.428 0.791 0 rs16877387 Imputed C GENOTYPIC 5.85E−04 2.88E−02 1.7999 1.7462 0.1152 53.73 rs16877387 Imputed C RECESSIVE 1.06E−04 0.00243 1.8666 1.8409 0.2165 34.65 rs16938626 Imputed G DOMINANT 6.97E−05 6.97E−05 0.6537 0.6537 0.5901 0 rs1694334 Imputed G ADDITIVE 3.41E−03 1.76E−01 0.7552 0.7708 0.0228 73.54 rs16998821 Imputed C DOMINANT 2.75E−03 1.96E−01 0.7042 0.7334 0.018 75.11 rs1700400 Imputed T ADDITIVE 2.87E−04 1.62E−02 0.7267 0.7259 0.1095 54.78 rs17007620 Imputed G ADDITIVE 0.0002711 0.02062 1.4055 1.3946 0.0989 56.78 rs17007620 Imputed G DOMINANT 0.0001384 0.003404 1.5358 1.5258 0.1998 37.9 rs17023290 Imputed C DOMINANT 0.003653 0.1786 1.4802 1.4969 0.0084 79.08 rs17047957 Imputed C DOMINANT 2.41E−05 2.41E−05 1.6313 1.6313 0.7603 0 rs1705237 Imputed A DOMINANT 1.23E−05 3.98E−05 0.5877 0.5877 0.326 10.78 rs1705261 Imputed A GENOTYPIC 2.16E−05 2.16E−05 1.9729 1.9729 0.7039 0 rs1705261 Imputed A RECESSIVE 3.71E−06 3.71E−06 1.9521 1.9521 0.9207 0 rs17076972 Imputed C ADDITIVE 0.0005241 0.01788 1.2997 1.2903 0.1408 48.99 rs17076972 Imputed C GENOTYPIC 0.0004395 0.02097 1.7025 1.6732 0.1233 52.23 rs17076972 Imputed C RECESSIVE 7.62E−04 4.50E−02 1.5342 1.5023 0.0868 59.08 rs17189710 Imputed T ADDITIVE 3.68E−05 3.68E−05 1.3739 1.3739 0.9395 0 rs17189710 Imputed T GENOTYPIC 2.19E−05 2.19E−05 2.0119 2.0119 0.9089 0 rs17196143 Imputed A ADDITIVE 1.68E−02 4.65E−01 1.2599 1.2043 0.0013 84.9 rs17353809 Imputed G ADDITIVE 7.94E−04 4.73E−02 1.3563 1.3441 0.0746 61.48 rs17368986 Imputed A GENOTYPIC 0.0003311 0.01194 2.721 2.5843 0.1676 44.02 rs17369097 Imputed A GENOTYPIC 2.42E−04 1.85E−03 2.7571 2.7036 0.2673 24.2 rs17434511 Imputed C GENOTYPIC 0.0003164 0.0117 2.7302 2.5932 0.1672 44.1 rs17434589 Imputed C GENOTYPIC 0.0002946 0.01171 2.7449 2.6054 0.1643 44.62 rs17434603 Imputed G GENOTYPIC 0.0003271 0.01143 2.7233 2.5889 0.1701 43.55 rs17434840 Imputed C GENOTYPIC 0.0002417 0.001846 2.7571 2.7036 0.2673 24.2 rs17446418 Imputed G DOMINANT 0.0005194 0.08804 0.6822 0.714 0.0469 67.33 rs17530747 Imputed T DOMINANT 0.0003577 0.0827 0.6735 0.7062 0.0438 68.03 rs17604285 Imputed C ADDITIVE 0.0001077 0.01983 0.5857 0.5921 0.0823 59.95 rs17604285 Imputed C DOMINANT 0.0001272 0.02188 0.5769 0.5823 0.0746 61.48 rs17662322 Imputed T DOMINANT 8.83E−05 8.83E−05 0.6424 0.6424 0.4888 0 rs17769826 Imputed T ADDITIVE 0.0008578 0.04731 1.3535 1.3419 0.0766 61.08 rs17821641 Imputed T ADDITIVE 0.0009123 0.02815 1.348 1.3411 0.1188 53.05 rs1782328 Imputed A ADDITIVE 0.0002285 0.0184 0.687 0.6954 0.116 53.58 rs1796337 Imputed T DOMINANT 5.74E−05 5.74E−05 0.6075 0.6075 0.7452 0 rs1798083 Imputed C DOMINANT 2.91E−05 2.91E−05 0.602 0.602 0.3963 0 rs1798085 Imputed T DOMINANT 1.95E−05 3.15E−05 0.5952 0.5951 0.3506 4.59 rs1798086 Imputed T DOMINANT 8.08E−06 1.64E−05 0.5778 0.5781 0.3453 5.95 rs1798089 Imputed C GENOTYPIC 9.52E−05 9.52E−05 2.0099 2.0099 0.7968 0 rs1798089 Imputed C RECESSIVE 1.73E−05 1.73E−05 1.9885 1.9885 0.8721 0 rs1798090 Imputed C GENOTYPIC 8.44E−05 8.44E−05 2.0204 2.0204 0.8325 0 rs1798090 Imputed C RECESSIVE 2.27E−05 2.27E−05 1.9652 1.9652 0.894 0 rs1832222 Imputed G DOMINANT 5.87E−05 5.87E−05 1.5311 1.5311 0.4163 0 rs1838104 Imputed A ADDITIVE 0.0002117 0.003729 0.7525 0.7527 0.2031 37.26 rs1838104 Imputed A GENOTYPIC 0.0002138 0.002807 0.5646 0.5645 0.2213 33.7 rs1868616 Imputed G ADDITIVE 7.48E−05 0.0004629 0.6753 0.6791 0.2929 18.56 rs1874313 Imputed A DOMINANT 3.30E−05 3.30E−05 0.6312 0.6312 0.6562 0 rs1884902 Imputed C RECESSIVE 0.001151 0.07621 1.6251 1.5839 0.0555 65.41 rs1913201 Imputed G ADDITIVE 1.89E−05 1.89E−05 0.7164 0.7164 0.8808 0 rs1913201 Imputed G DOMINANT 2.91E−05 2.91E−05 0.6172 0.6172 0.7641 0 rs1913201 Imputed G GENOTYPIC 7.80E−05 7.80E−05 0.5351 0.5351 0.6861 0 rs1944279 Imputed A ADDITIVE 0.0001257 0.005478 1.3904 1.3724 0.1829 41.13 rs198461 Imputed C DOMINANT 1.66E−06 1.66E−06 0.5498 0.5498 0.6534 0 rs1987179 Imputed T DOMINANT 7.08E−05 7.08E−05 0.641 0.641 0.5343 0 rs1990023 Imputed T DOMINANT 2.55E−07 2.55E−07 0.5746 0.5746 0.9225 0 rs2016194 Imputed G DOMINANT 4.26E−07 4.26E−07 0.5804 0.5804 0.9558 0 rs2024789 Imputed C ADDITIVE 0.0008551 0.04722 0.7786 0.789 0.0866 59.13 rs2024789 Imputed C GENOTYPIC 0.001077 0.04627 0.6104 0.625 0.0938 57.75 rs2024902 Imputed A ADDITIVE 0.0004002 0.02334 1.7111 1.7273 0.0887 58.72 rs2024902 Imputed A DOMINANT 9.43E−05 0.01112 1.8804 1.8895 0.0981 56.93 rs2025107 Imputed A ADDITIVE 0.0005021 0.06161 1.6166 1.6531 0.0272 72.27 rs2025107 Imputed A DOMINANT 0.0001126 0.05784 1.7901 1.8228 0.0156 75.95 rs2025108 Imputed T ADDITIVE 0.0005021 0.06161 1.6166 1.6531 0.0272 72.27 rs2025108 Imputed T DOMINANT 0.0001126 0.05784 1.7901 1.8228 0.0156 75.95 rs2062448 Imputed T ADDITIVE 0.0001197 0.0124 0.5855 0.5897 0.1132 54.1 rs2062448 Imputed T DOMINANT 0.0001438 0.01375 0.5765 0.5801 0.1057 55.5 rs2063591 Imputed C ADDITIVE 6.31E−05 6.31E−05 0.7382 0.7382 0.9476 0 rs2063591 Imputed C DOMINANT 1.50E−05 1.50E−05 0.6047 0.6047 0.7317 0 rs2065604 Imputed C DOMINANT 0.003098 0.1472 0.6558 0.6652 0.0252 72.84 rs2066238 Imputed T DOMINANT 0.00258 0.1967 0.7027 0.7323 0.0172 75.39 rs2068051 Imputed G ADDITIVE 0.0001657 0.004859 0.6917 0.7008 0.2023 37.41 rs2068051 Imputed G GENOTYPIC 0.0002673 0.007654 0.4817 0.4968 0.1931 39.2 rs2077702 Genotyped G GENOTYPIC 9.79E−05 9.79E−05 2.0248 2.0248 0.5151 0 rs208757 Imputed G ADDITIVE 4.49E−05 4.49E−05 1.5013 1.5013 0.8401 0 rs208757 Imputed G DOMINANT 9.41E−06 9.41E−06 1.6603 1.6603 0.7321 0 rs2095586 Imputed A DOMINANT 5.72E−05 5.72E−05 1.532 1.532 0.4194 0 rs2108426 Imputed C DOMINANT 4.02E−07 4.02E−07 0.5797 0.5797 0.9591 0 rs2110664 Imputed A DOMINANT 8.67E−05 8.67E−05 1.5394 1.5394 0.8744 0 rs2132242 Imputed A DOMINANT 2.72E−05 2.72E−05 0.6282 0.6282 0.7958 0 rs2151644 Imputed T DOMINANT 0.003131 0.1517 0.656 0.6657 0.0236 73.31 rs2157752 Genotyped A GENOTYPIC 0.0009168 0.05016 0.5431 0.5628 0.0902 58.44 rs2158958 Imputed A DOMINANT 4.20E−07 4.20E−07 0.5804 0.5804 0.9556 0 rs2158961 Imputed G DOMINANT 1.33E−06 1.33E−06 0.5977 0.5977 0.8737 0 rs2164099 Imputed G ADDITIVE 0.0001863 0.006344 1.376 1.3584 0.1883 40.11 rs2173254 Imputed G GENOTYPIC 0.002362 0.118 0.5447 0.533 0.0217 73.89 rs2173254 Imputed G RECESSIVE 0.002217 0.0789 0.5578 0.5403 0.042 68.46 rs2188079 Imputed C ADDITIVE 0.0001838 0.02268 1.3319 1.321 0.0862 59.19 rs2188079 Imputed C GENOTYPIC 0.0001122 0.0128 1.8273 1.7987 0.1109 54.53 rs2190304 Imputed G RECESSIVE 0.01058 0.4116 0.7116 0.7366 0.0005 86.94 rs2190597 Imputed T DOMINANT 9.78E−05 9.78E−05 0.6395 0.6395 0.4926 0 rs2190598 Imputed T DOMINANT 4.20E−07 4.20E−07 0.5804 0.5804 0.9556 0 rs2190600 Imputed A DOMINANT 3.37E−07 3.37E−07 0.5762 0.5762 0.9653 0 rs2218084 Imputed T GENOTYPIC 9.58E−05 9.58E−05 3.531 3.531 0.7772 0 rs2218084 Imputed T RECESSIVE 8.93E−05 8.93E−05 3.5234 3.5234 0.8908 0 rs2236290 Genotyped C GENOTYPIC 6.42E−05 6.42E−05 0.4993 0.4993 0.9011 0 rs2243860 Imputed A GENOTYPIC 7.41E−05 7.41E−05 2.0648 2.0648 0.8032 0 rs2243860 Imputed A RECESSIVE 8.56E−05 8.56E−05 1.9204 1.9204 0.6639 0 rs2246564 Imputed T DOMINANT 0.003098 0.1472 0.6558 0.6652 0.0252 72.84 rs2248236 Imputed C DOMINANT 7.76E−05 7.76E−05 0.6498 0.6498 0.545 0 rs2250340 Imputed T DOMINANT 0.003303 0.1528 0.6523 0.6609 0.0229 73.54 rs2257192 Imputed G DOMINANT 0.003098 0.1472 0.6558 0.6652 0.0252 72.84 rs2270584 Imputed A DOMINANT 4.80E−06 4.80E−06 0.605 0.605 0.7982 0 rs2270586 Imputed A DOMINANT 5.31E−06 5.31E−06 0.6041 0.6041 0.7347 0 rs2270589 Imputed A ADDITIVE 2.81E−06 2.81E−06 0.6877 0.6877 0.8813 0 rs2270589 Imputed A DOMINANT 2.60E−07 2.60E−07 0.5336 0.5336 0.71 0 rs2270589 Imputed A GENOTYPIC 1.28E−05 1.28E−05 0.4977 0.4977 0.7794 0 rs2296889 Imputed C DOMINANT 0.002588 0.1138 1.4232 1.4076 0.0374 69.56 rs2301346 Imputed C ADDITIVE 0.0002178 0.0338 1.3978 1.3772 0.0701 62.37 rs2301346 Imputed C DOMINANT 0.0001352 0.02587 1.5644 1.5455 0.0672 62.97 rs2327929 Imputed G RECESSIVE 1.06E−05 1.06E−05 1.7928 1.7928 0.4369 0 rs2357486 Imputed C RECESSIVE 0.00295 0.1854 1.7126 1.6148 0.024 73.18 rs2373793 Imputed G DOMINANT 4.57E−05 4.57E−05 1.617 1.617 0.8752 0 rs2377622 Imputed T GENOTYPIC 2.11E−05 2.11E−05 0.3896 0.3896 0.7037 0 rs2377622 Imputed T RECESSIVE 2.44E−05 2.44E−05 0.4115 0.4115 0.6397 0 rs2383903 Imputed G DOMINANT 3.69E−05 3.69E−05 0.645 0.645 0.6185 0 rs2389866 Imputed C DOMINANT 4.60E−05 4.60E−05 0.6408 0.6408 0.6066 0 rs2389869 Imputed C DOMINANT 4.60E−05 4.60E−05 0.6408 0.6408 0.6066 0 rs2418541 Imputed A DOMINANT 3.36E−07 3.36E−07 0.5781 0.5781 0.9145 0 rs2418542 Imputed A DOMINANT 3.36E−07 3.36E−07 0.5781 0.5781 0.9145 0 rs2418548 Imputed C DOMINANT 2.36E−06 2.36E−06 0.598 0.598 0.9168 0 rs2476976 Imputed C DOMINANT 7.42E−05 7.42E−05 1.5229 1.5229 0.5546 0 rs2483639 Imputed A DOMINANT 0.003098 0.1472 0.6558 0.6652 0.0252 72.84 rs2483640 Imputed A DOMINANT 0.003098 0.1472 0.6558 0.6652 0.0252 72.84 rs2544780 Imputed T RECESSIVE 7.90E−05 7.90E−05 2.0334 2.0334 0.4674 0 rs2586458 Imputed T DOMINANT 0.03011 0.336 0.7195 0.6895 0.0016 84.47 rs2593272 Imputed G ADDITIVE 0.0002545 0.004989 0.7307 0.7296 0.1874 40.27 rs2593273 Imputed T ADDITIVE 0.0005623 0.03 0.7408 0.7417 0.0868 59.09 rs2622499 Imputed G DOMINANT 9.25E−05 9.25E−05 0.6531 0.6531 0.5221 0 rs264126 Imputed C DOMINANT 8.31E−05 8.31E−05 0.6369 0.6369 0.4319 0 rs264129 Imputed T DOMINANT 1.21E−06 1.21E−06 0.5966 0.5966 0.8652 0 rs2656822 Imputed T ADDITIVE 0.0002545 0.004989 0.7307 0.7296 0.1874 40.27 rs2656823 Imputed G ADDITIVE 0.0002545 0.004989 0.7307 0.7296 0.1874 40.27 rs2656825 Imputed T ADDITIVE 0.0008702 0.04621 0.7415 0.7347 0.0581 64.86 rs2764766 Imputed C RECESSIVE 8.08E−05 8.08E−05 2.0146 2.0146 0.461 0 rs2793101 Imputed T ADDITIVE 0.001506 0.1134 0.6664 0.691 0.0408 68.75 rs2793101 Imputed T DOMINANT 0.001377 0.07663 0.6498 0.6704 0.0666 63.09 rs2795871 Imputed A ADDITIVE 7.48E−05 7.48E−05 0.5195 0.5195 0.5044 0 rs2795886 Imputed A ADDITIVE 4.74E−05 4.74E−05 0.4603 0.4603 0.6122 0 rs2795886 Imputed A DOMINANT 7.68E−05 7.68E−05 0.4623 0.4623 0.6008 0 rs2859994 Imputed C GENOTYPIC 0.001111 0.04898 1.7472 1.7054 0.0857 59.3 rs2870464 Imputed G DOMINANT 9.42E−05 9.42E−05 1.6183 1.6183 0.5381 0 rs2875528 Imputed T DOMINANT 0.00249 0.1329 1.4996 1.5256 0.0141 76.54 rs2876227 Imputed C ADDITIVE 2.20E−05 2.20E−05 1.3926 1.3926 0.9997 0 rs2876227 Imputed C GENOTYPIC 1.68E−05 1.68E−05 2.0556 2.0556 0.8801 0 rs2882097 Imputed A DOMINANT 5.09E−05 5.09E−05 1.5361 1.5361 0.4725 0 rs2921983 Imputed C ADDITIVE 0.0001118 0.003732 0.7041 0.7047 0.1767 42.31 rs2987537 Imputed C DOMINANT 0.03897 0.4969 0.7689 0.776 0.0002 88.03 rs2996416 Imputed C ADDITIVE 0.0637 0.5796 0.7893 0.8032 0.0001 89.2 rs2996416 Imputed C DOMINANT 0.06194 0.5554 0.775 0.7758 0.0001 89.6 rs3015527 Imputed C ADDITIVE 0.07495 0.6564 0.7934 0.8312 0.0001 89.8 rs3015527 Imputed C DOMINANT 0.07947 0.6402 0.7832 0.8084 0 90.3 rs3015530 Imputed C ADDITIVE 0.06224 0.577 0.7882 0.8017 0.0001 89.23 rs3015530 Imputed C DOMINANT 0.06057 0.5529 0.7739 0.7744 0.0001 89.62 rs3015531 Imputed T ADDITIVE 0.06224 0.577 0.7882 0.8017 0.0001 89.23 rs3015531 Imputed T DOMINANT 0.06057 0.5529 0.7739 0.7744 0.0001 89.62 rs3015535 Imputed C ADDITIVE 0.06224 0.577 0.7882 0.8017 0.0001 89.23 rs3015535 Imputed C DOMINANT 0.06057 0.5529 0.7739 0.7744 0.0001 89.62 rs3019407 Imputed A GENOTYPIC 0.002403 0.1245 0.5457 0.5319 0.0182 75.03 rs3019407 Imputed A RECESSIVE 0.001969 0.0794 0.5543 0.5343 0.0367 69.74 rs36071725 Genotyped C GENOTYPIC 0.0009841 0.1525 1.8209 1.6916 0.0188 74.82 rs373983 Imputed G DOMINANT 1.77E−06 4.87E−05 1.7251 1.7129 0.2675 24.16 rs3756154 Imputed C DOMINANT 5.58E−05 5.58E−05 0.638 0.638 0.5323 0 rs3793044 Imputed C ADDITIVE 0.0002176 0.02467 1.7666 1.7835 0.0668 63.04 rs3793044 Imputed C DOMINANT 6.05E−05 0.01168 1.9281 1.9369 0.0827 59.88 rs3793053 Imputed C ADDITIVE 0.0006473 0.05829 1.6129 1.6372 0.0373 69.61 rs3793053 Imputed C DOMINANT 0.0001802 0.05295 1.7738 1.7934 0.0253 72.81 rs3796246 Imputed G ADDITIVE 4.93E−05 0.03123 0.5626 0.5598 0.033 70.67 rs3796246 Imputed G DOMINANT 7.61E−05 0.03997 0.5604 0.5582 0.0279 72.06 rs3805996 Imputed G ADDITIVE 0.0004631 0.03555 1.7203 1.7316 0.0645 63.52 rs3805996 Imputed G DOMINANT 0.0001039 0.01905 1.8935 1.8966 0.069 62.59 rs3806003 Imputed A ADDITIVE 0.0002176 0.02467 1.7666 1.7835 0.0668 63.04 rs3806003 Imputed A DOMINANT 6.05E−05 0.01168 1.9281 1.9369 0.0827 59.88 rs3806004 Imputed T ADDITIVE 0.0004046 0.06127 1.629 1.6716 0.0232 73.43 rs3806004 Imputed T DOMINANT 8.69E−05 0.05774 1.806 1.8451 0.013 76.96 rs3806010 Imputed T ADDITIVE 0.0005021 0.06161 1.6166 1.6531 0.0272 72.27 rs3806010 Imputed T DOMINANT 0.0001126 0.05784 1.7901 1.8228 0.0156 75.95 rs3806014 Imputed T ADDITIVE 0.0003765 0.04916 1.6371 1.6672 0.0355 70.04 rs3806014 Imputed T DOMINANT 8.67E−05 0.04874 1.8125 1.8369 0.0201 74.42 rs3806015 Imputed A ADDITIVE 0.0004101 0.05336 1.6326 1.6624 0.0328 70.72 rs3806015 Imputed A DOMINANT 9.18E−05 0.05129 1.8094 1.8329 0.019 74.77 rs3806018 Imputed A ADDITIVE 0.0005021 0.06161 1.6166 1.6531 0.0272 72.27 rs3806018 Imputed A DOMINANT 0.0001126 0.05784 1.7901 1.8228 0.0156 75.95 rs3806019 Imputed A ADDITIVE 0.0003369 0.06994 1.6486 1.6857 0.017 75.46 rs3806019 Imputed A DOMINANT 7.78E−05 0.06342 1.8244 1.854 0.0108 77.94 rs3806024 Imputed T ADDITIVE 0.0005633 0.04683 1.6102 1.6476 0.0429 68.25 rs3806024 Imputed T DOMINANT 0.0001927 0.05215 1.7603 1.7924 0.0243 73.09 rs3847825 Imputed G ADDITIVE 2.82E−05 2.82E−05 0.7256 0.7256 0.8316 0 rs3847825 Imputed G GENOTYPIC 1.92E−05 1.92E−05 0.492 0.492 0.6711 0 rs3852001 Genotyped C GENOTYPIC 0.0001464 0.003339 2.8436 2.7528 0.2138 35.18 rs3852001 Genotyped C RECESSIVE 0.0002312 0.004125 2.7294 2.6501 0.2177 34.41 rs3852002 Imputed G GENOTYPIC 0.0001829 0.002345 2.8057 2.7354 0.2427 29.38 rs3852002 Imputed G RECESSIVE 0.0003087 0.003378 2.6791 2.6162 0.2416 29.6 rs3852003 Imputed A GENOTYPIC 0.0001804 0.002239 2.8085 2.7392 0.2448 28.95 rs3852003 Imputed A RECESSIVE 0.0003059 0.003283 2.6808 2.6185 0.243 29.31 rs3942254 Imputed T DOMINANT 1.57E−05 1.57E−05 0.6155 0.6155 0.9263 0 rs3945085 Imputed A DOMINANT 4.70E−05 4.70E−05 1.5394 1.5394 0.4131 0 rs399485 Imputed A DOMINANT 6.74E−05 6.74E−05 1.5257 1.5257 0.824 0 rs4029119 Imputed G ADDITIVE 0.009526 0.1165 0.5497 0.3516 0.0037 82.15 rs4029119 Imputed G DOMINANT 0.01808 0.1591 0.5432 0.3678 0.0036 82.19 rs412791 Imputed C GENOTYPIC 0.001957 0.1114 0.5748 0.6018 0.0485 66.96 rs4146972 Genotyped T DOMINANT 5.77E−05 5.77E−05 1.5876 1.5876 0.6206 0 rs4259369 Imputed C RECESSIVE 8.16E−05 8.16E−05 0.5849 0.5849 0.3771 0 rs4273613 Imputed T ADDITIVE 0.008222 0.1202 0.5498 0.3996 0.0061 80.4 rs4273613 Imputed T DOMINANT 0.01557 0.1677 0.5436 0.4204 0.006 80.44 rs4294022 Imputed C DOMINANT 0.001643 0.075 0.7108 0.7149 0.0535 65.84 rs4310554 Genotyped C DOMINANT 8.90E−05 8.90E−05 1.6571 1.6571 0.9259 0 rs4315598 Imputed T ADDITIVE 3.44E−05 3.44E−05 1.3737 1.3737 0.9473 0 rs4315598 Imputed T GENOTYPIC 2.26E−05 2.26E−05 2.0022 2.0022 0.9124 0 rs4370878 Imputed G DOMINANT 7.67E−05 7.67E−05 1.5204 1.5204 0.455 0 rs4436200 Imputed C ADDITIVE 9.10E−05 9.10E−05 0.6326 0.6326 0.5686 0 rs4444612 Imputed G ADDITIVE 3.11E−05 3.11E−05 1.376 1.376 0.9378 0 rs4444612 Imputed G GENOTYPIC 2.11E−05 2.11E−05 2.0071 2.0071 0.9192 0 rs4450660 Imputed C DOMINANT 4.65E−05 4.65E−05 1.546 1.546 0.4995 0 rs4463950 Imputed C DOMINANT 0.0001125 0.0001125 0.6464 0.6464 0.456 0 rs4509702 Imputed C DOMINANT 7.67E−05 7.67E−05 1.5204 1.5204 0.455 0 rs4533379 Imputed G ADDITIVE 0.0001806 0.006299 1.3772 1.3597 0.1875 40.27 rs4569984 Imputed A DOMINANT 0.001158 0.06124 0.7017 0.7047 0.0591 64.65 rs4570530 Imputed C DOMINANT 6.91E−05 6.91E−05 1.5246 1.5246 0.4388 0 rs4571583 Imputed T DOMINANT 0.001089 0.04319 0.7015 0.7036 0.0837 59.69 rs4586678 Imputed A DOMINANT 7.84E−05 7.84E−05 1.5241 1.5241 0.4333 0 rs4615971 Imputed C DOMINANT 5.32E−05 5.32E−05 1.5364 1.5364 0.4014 0 rs4629229 Imputed G DOMINANT 0.00258 0.1967 0.7027 0.7323 0.0172 75.39 rs4632512 Imputed T GENOTYPIC 0.0002417 0.001846 2.7571 2.7036 0.2673 24.2 rs4641552 Imputed A ADDITIVE 6.42E−05 6.42E−05 0.5503 0.5503 0.8687 0 rs4682527 Imputed C DOMINANT 6.46E−05 6.46E−05 1.7014 1.7014 0.8635 0 rs4688632 Imputed G RECESSIVE 9.44E−05 9.44E−05 0.6102 0.6102 0.6914 0 rs4702720 Imputed A ADDITIVE 6.79E−05 6.79E−05 0.6668 0.6668 0.5886 0 rs4702720 Imputed A DOMINANT 5.81E−05 5.81E−05 0.6111 0.6111 0.6679 0 rs4714484 Imputed A ADDITIVE 0.0001156 0.0001156 0.6714 0.6714 0.4129 0 rs4714484 Imputed A DOMINANT 0.0001018 0.0005019 0.6342 0.6347 0.2947 18.15 rs4725142 Genotyped G RECESSIVE 0.006009 0.1578 0.6241 0.5998 0.0142 76.48 rs4725144 Imputed G RECESSIVE 0.003615 0.1263 0.601 0.5821 0.0196 74.58 rs4760785 Imputed A ADDITIVE 2.89E−05 2.89E−05 0.7236 0.7236 0.9224 0 rs4760785 Imputed A DOMINANT 3.37E−05 3.37E−05 0.6199 0.6199 0.7756 0 rs4760894 Imputed T ADDITIVE 2.89E−05 2.89E−05 0.7236 0.7236 0.9224 0 rs4760894 Imputed T DOMINANT 3.37E−05 3.37E−05 0.6199 0.6199 0.7756 0 rs4760895 Imputed A ADDITIVE 2.89E−05 2.89E−05 0.7236 0.7236 0.9224 0 rs4760895 Imputed A DOMINANT 3.37E−05 3.37E−05 0.6199 0.6199 0.7756 0 rs4767184 Imputed C ADDITIVE 5.36E−05 5.36E−05 0.7326 0.7326 0.8638 0 rs4767184 Imputed C GENOTYPIC 4.89E−05 4.89E−05 0.5118 0.5118 0.7734 0 rs4773487 Imputed T ADDITIVE 0.06464 0.5842 0.7937 0.8107 0.0001 88.81 rs4780547 Imputed G GENOTYPIC 5.45E−05 5.45E−05 0.3432 0.3432 0.6588 0 rs4780547 Imputed G RECESSIVE 5.24E−05 5.24E−05 0.3485 0.3485 0.7035 0 rs483159 Imputed T DOMINANT 1.80E−05 9.87E−05 1.6374 1.6337 0.3052 15.73 rs4836502 Imputed T DOMINANT 4.20E−07 4.20E−07 0.5804 0.5804 0.9556 0 rs4836507 Imputed C DOMINANT 3.81E−07 3.81E−07 0.5776 0.5776 0.9618 0 rs4851531 Imputed T DOMINANT 6.05E−05 6.05E−05 0.6433 0.6433 0.6076 0 rs4879931 Imputed G ADDITIVE 4.07E−05 4.07E−05 0.7128 0.7128 0.8034 0 rs489441 Imputed G ADDITIVE 5.61E−05 5.61E−05 1.4311 1.4311 0.5197 0 rs489441 Imputed G DOMINANT 2.23E−05 2.23E−05 1.5959 1.5959 0.6258 0 rs4976276 Imputed T ADDITIVE 0.001258 0.05097 1.303 1.2929 0.0811 60.2 rs4977681 Imputed C RECESSIVE 0.00128 0.05237 1.78 1.7408 0.0817 60.08 rs4986197 Imputed G ADDITIVE 0.0001721 0.0051 1.3789 1.3622 0.1995 37.96 rs4986220 Imputed T ADDITIVE 0.0002571 0.00494 1.3704 1.3563 0.2157 34.81 rs525462 Imputed A GENOTYPIC 8.63E−05 8.63E−05 0.5509 0.5509 0.4841 0 rs552006 Imputed G GENOTYPIC 0.001362 0.0951 1.9014 1.8396 0.056 65.31 rs5756669 Imputed C DOMINANT 0.0005154 0.01565 1.5032 1.4817 0.1536 46.63 rs581905 Imputed T DOMINANT 9.62E−05 9.62E−05 1.7493 1.7493 0.4492 0 rs6033138 Imputed C ADDITIVE 3.11E−05 3.11E−05 1.376 1.376 0.9378 0 rs6033138 Imputed C GENOTYPIC 2.11E−05 2.11E−05 2.0071 2.0071 0.9192 0 rs6040619 Imputed C ADDITIVE 1.85E−05 1.85E−05 1.3887 1.3887 0.9157 0 rs6040619 Imputed C GENOTYPIC 1.34E−05 1.34E−05 2.0393 2.0393 0.8907 0 rs6040625 Imputed T ADDITIVE 1.40E−05 1.40E−05 1.3939 1.3939 0.9254 0 rs6040625 Imputed T GENOTYPIC 1.13E−05 1.13E−05 2.049 2.049 0.9295 0 rs6040630 Imputed A ADDITIVE 1.64E−05 1.64E−05 1.3913 1.3913 0.9442 0 rs6040630 Imputed A GENOTYPIC 1.40E−05 1.40E−05 2.0387 2.0387 0.936 0 rs6040633 Imputed A ADDITIVE 2.09E−05 2.09E−05 1.3848 1.3848 0.9611 0 rs6040633 Imputed A GENOTYPIC 1.80E−05 1.80E−05 2.0179 2.0179 0.921 0 rs6040634 Imputed T ADDITIVE 4.42E−05 4.42E−05 1.3644 1.3644 0.8661 0 rs6040634 Imputed T GENOTYPIC 4.35E−05 4.35E−05 1.9421 1.9421 0.8577 0 rs6040636 Imputed T ADDITIVE 5.80E−05 5.80E−05 1.3581 1.3581 0.8982 0 rs6040636 Imputed T GENOTYPIC 5.08E−05 5.08E−05 1.9311 1.9311 0.8975 0 rs6040638 Imputed C ADDITIVE 3.11E−05 3.11E−05 1.376 1.376 0.9378 0 rs6040638 Imputed C GENOTYPIC 2.11E−05 2.11E−05 2.0071 2.0071 0.9192 0 rs6040644 Imputed A ADDITIVE 3.11E−05 3.11E−05 1.376 1.376 0.9378 0 rs6040644 Imputed A GENOTYPIC 2.11E−05 2.11E−05 2.0071 2.0071 0.9192 0 rs6040667 Imputed T ADDITIVE 9.98E−06 9.98E−06 1.4087 1.4087 0.9927 0 rs6040667 Imputed T GENOTYPIC 9.55E−06 9.55E−06 2.0887 2.0887 0.8885 0 rs6040668 Imputed C ADDITIVE 1.34E−05 1.34E−05 1.4018 1.4018 0.9954 0 rs6040668 Imputed C GENOTYPIC 1.18E−05 1.18E−05 2.0792 2.0792 0.9007 0 rs6053005 Imputed C DOMINANT 3.48E−05 3.48E−05 0.4986 0.4986 0.3762 0 rs6054405 Imputed A RECESSIVE 0.0009988 0.07764 1.6353 1.5918 0.0508 66.45 rs6054427 Genotyped G GENOTYPIC 0.002955 0.1457 1.6159 1.564 0.0304 71.38 rs6075186 Imputed G DOMINANT 0.00258 0.1967 0.7027 0.7323 0.0172 75.39 rs608278 Imputed A ADDITIVE 0.004256 0.2162 0.7899 0.8041 0.0123 77.26 rs6111540 Imputed A ADDITIVE 0.0006805 0.04588 0.7626 0.7772 0.0894 58.58 rs6131206 Imputed C ADDITIVE 6.54E−05 6.54E−05 1.3826 1.3826 0.6671 0 rs6131208 Imputed T ADDITIVE 1.51E−05 1.51E−05 1.3987 1.3987 0.9933 0 rs6131208 Imputed T GENOTYPIC 1.23E−05 1.23E−05 2.0749 2.0749 0.9062 0 rs6131919 Imputed G DOMINANT 0.00258 0.1967 0.7027 0.7323 0.0172 75.39 rs6134243 Imputed C ADDITIVE 3.11E−05 3.11E−05 1.376 1.376 0.9378 0 rs6134243 Imputed C GENOTYPIC 2.11E−05 2.11E−05 2.0071 2.0071 0.9192 0 rs6136020 Imputed A DOMINANT 0.001123 0.128 0.6825 0.7095 0.029 71.76 rs613799 Imputed C DOMINANT 6.64E−05 6.64E−05 1.5582 1.5582 0.563 0 rs644041 Imputed G ADDITIVE 5.13E−05 5.13E−05 1.4383 1.4383 0.434 0 rs644041 Imputed G DOMINANT 3.43E−05 3.43E−05 1.5867 1.5867 0.604 0 rs6464377 Imputed C DOMINANT 0.0006889 0.03533 1.6713 1.6228 0.1067 55.32 rs6474230 Imputed T DOMINANT 5.89E−05 5.89E−05 1.5358 1.5358 0.5248 0 rs6476565 Imputed A DOMINANT 0.003196 0.152 0.6555 0.6646 0.0232 73.43 rs6511286 Imputed T ADDITIVE 0.0002903 0.007727 1.3303 1.3382 0.1549 46.38 rs6541829 Genotyped C RECESSIVE 9.75E−05 9.75E−05 2.1906 2.1906 0.675 0 rs6544721 Imputed G DOMINANT 6.03E−05 6.03E−05 1.5337 1.5337 0.3986 0 rs6544728 Imputed T DOMINANT 2.14E−05 2.14E−05 1.5769 1.5769 0.5608 0 rs6565910 Imputed G DOMINANT 0.001296 0.07989 0.7061 0.72 0.0544 65.66 rs6581985 Imputed G GENOTYPIC 2.27E−05 2.27E−05 2.3281 2.3281 0.8 0 rs6581985 Imputed G RECESSIVE 1.65E−05 1.65E−05 2.2816 2.2816 0.9608 0 rs6685186 Imputed T ADDITIVE 0.0003893 0.03193 1.3177 1.2933 0.1024 56.12 rs6685186 Imputed T GENOTYPIC 0.0003148 0.008032 1.8077 1.753 0.2038 37.13 rs670593 Imputed A RECESSIVE 9.20E−05 9.20E−05 0.5443 0.5443 0.5165 0 rs6722640 Imputed T DOMINANT 3.75E−05 3.75E−05 0.6354 0.6354 0.7462 0 rs6746170 Imputed A DOMINANT 1.59E−05 1.59E−05 1.5871 1.5871 0.5677 0 rs6757316 Imputed A GENOTYPIC 7.94E−05 7.94E−05 1.8639 1.8639 0.8329 0 rs6805139 Imputed G DOMINANT 6.87E−05 6.87E−05 1.6408 1.6408 0.6877 0 rs6808571 Imputed G ADDITIVE 0.0001557 0.005296 1.488 1.4637 0.1931 39.2 rs6816479 Imputed A RECESSIVE 0.003461 0.1734 1.5638 1.5108 0.0221 73.76 rs6865976 Imputed C DOMINANT 0.000638 0.09658 0.6509 0.6693 0.03 71.48 rs687047 Imputed C ADDITIVE 8.99E−05 8.99E−05 0.6274 0.6274 0.7784 0 rs6871041 Imputed G DOMINANT 1.95E−06 1.95E−06 0.5936 0.5936 0.8021 0 rs688358 Imputed A ADDITIVE 9.13E−05 9.13E−05 0.6275 0.6275 0.8668 0 rs6908481 Imputed C RECESSIVE 2.63E−05 2.63E−05 1.8066 1.8066 0.4929 0 rs6917224 Imputed A ADDITIVE 0.001611 0.08952 1.2619 1.2426 0.0537 65.81 rs6917224 Imputed A GENOTYPIC 0.0004783 0.01846 1.6983 1.6636 0.1376 49.58 rs6920677 Imputed G DOMINANT 0.0006978 0.02695 0.6902 0.689 0.1022 56.16 rs6994498 Imputed G DOMINANT 6.45E−05 6.45E−05 1.5326 1.5326 0.525 0 rs6998772 Imputed T DOMINANT 0.0001667 0.007582 2.0855 2.0402 0.1794 41.79 rs7022281 Imputed C ADDITIVE 3.37E−05 3.37E−05 0.7208 0.7208 0.9446 0 rs7022281 Imputed C GENOTYPIC 1.15E−05 1.15E−05 0.4698 0.4698 0.7053 0 rs7022281 Imputed C RECESSIVE 5.13E−05 5.13E−05 0.5256 0.5256 0.4654 0 rs7043983 Imputed T DOMINANT 0.002465 0.1237 0.6468 0.6573 0.0334 70.58 rs7077799 Imputed A DOMINANT 6.50E−05 6.50E−05 1.5274 1.5274 0.444 0 rs7088947 Imputed A ADDITIVE 6.35E−05 6.35E−05 0.5164 0.5164 0.4696 0 rs7089661 Imputed C DOMINANT 5.72E−05 5.72E−05 1.532 1.532 0.4194 0 rs7102072 Imputed A DOMINANT 0.0002045 0.02025 0.6732 0.6851 0.1048 55.66 rs710832 Genotyped A RECESSIVE 9.58E−05 9.58E−05 0.3757 0.3757 0.7653 0 rs712531 Imputed A DOMINANT 3.11E−05 3.11E−05 1.7258 1.7258 0.9033 0 rs7129817 Imputed T ADDITIVE 0.0004049 0.005979 0.7557 0.7602 0.2144 35.05 rs7134262 Imputed T GENOTYPIC 3.73E−05 3.73E−05 2.0446 2.0446 0.769 0 rs7134262 Imputed T RECESSIVE 1.57E−06 1.57E−06 2.1811 2.1811 0.5132 0 rs7138300 Imputed C ADDITIVE 2.89E−05 2.89E−05 0.7236 0.7236 0.9224 0 rs7138300 Imputed C DOMINANT 3.37E−05 3.37E−05 0.6199 0.6199 0.7756 0 rs722927 Imputed G ADDITIVE 0.0002059 0.003095 0.5581 0.5621 0.2265 32.66 rs722927 Imputed G DOMINANT 0.0002882 0.006064 0.554 0.5592 0.1936 39.11 rs726424 Genotyped G ADDITIVE 6.99E−05 6.99E−05 0.7384 0.7384 0.8568 0 rs726424 Genotyped G GENOTYPIC 4.04E−05 4.04E−05 0.5084 0.5084 0.769 0 rs7295817 Imputed C ADDITIVE 3.56E−06 3.56E−06 0.701 0.701 0.8251 0 rs7295817 Imputed C GENOTYPIC 2.94E−06 2.94E−06 0.4697 0.4697 0.6858 0 rs7295817 Imputed C RECESSIVE 3.56E−05 3.56E−05 0.5434 0.5434 0.4419 0 rs7297372 Imputed A ADDITIVE 2.15E−05 2.15E−05 0.7143 0.7143 0.9056 0 rs7297372 Imputed A GENOTYPIC 2.33E−05 2.33E−05 0.5078 0.5078 0.9111 0 rs7298255 Imputed A ADDITIVE 5.48E−05 5.48E−05 0.7363 0.7363 0.9823 0 rs7298255 Imputed A DOMINANT 3.71E−05 3.71E−05 0.6235 0.6235 0.616 0 rs7305832 Imputed C GENOTYPIC 3.46E−05 3.46E−05 2.0496 2.0496 0.7658 0 rs7305832 Imputed C RECESSIVE 1.42E−06 1.42E−06 2.1877 2.1877 0.5185 0 rs737542 Imputed A RECESSIVE 6.40E−05 6.40E−05 2.2711 2.2711 0.5666 0 rs742827 Imputed A ADDITIVE 1.36E−05 1.36E−05 1.4066 1.4066 0.9977 0 rs742827 Imputed A GENOTYPIC 1.47E−05 1.47E−05 2.0678 2.0678 0.9063 0 rs7446891 Imputed G DOMINANT 4.14E−07 4.14E−07 0.5792 0.5792 0.9644 0 rs7448641 Imputed C ADDITIVE 0.008373 0.1243 0.5451 0.3771 0.0037 82.12 rs7448641 Imputed C DOMINANT 0.0151 0.1693 0.5356 0.3959 0.0036 82.2 rs7460605 Imputed G DOMINANT 9.83E−05 9.83E−05 1.5669 1.5669 0.9301 0 rs7468898 Imputed T ADDITIVE 0.0003194 0.01248 1.3212 1.3172 0.1401 49.12 rs7468898 Imputed T GENOTYPIC 0.0002964 0.008259 1.7563 1.7465 0.1684 43.86 rs7501186 Imputed A DOMINANT 9.69E−05 9.69E−05 1.6046 1.6046 0.3847 0 rs755117 Imputed A DOMINANT 0.01024 0.3598 1.3434 1.288 0.0039 81.94 rs7557560 Imputed T GENOTYPIC 0.0001246 0.01108 2.8561 3.1286 0.074 61.59 rs7557560 Imputed T RECESSIVE 6.13E−05 0.00416 2.9547 3.1843 0.1154 53.69 rs7562462 Imputed T DOMINANT 0.01544 0.4455 1.3282 1.2791 0.0007 86.22 rs757173 Genotyped G DOMINANT 0.0006476 0.08534 0.6914 0.7167 0.0461 67.51 rs7607447 Imputed T RECESSIVE 9.84E−05 9.84E−05 2.0418 2.0418 0.8641 0 rs7639053 Imputed A ADDITIVE 0.00063 0.02671 1.3617 1.3527 0.1105 54.61 rs7648163 Imputed C RECESSIVE 0.001045 0.07747 1.7344 1.7565 0.0313 71.14 rs7651273 Imputed A GENOTYPIC 0.0003041 0.01221 2.7407 2.6004 0.1624 44.99 rs7653190 Imputed C ADDITIVE 0.0008578 0.04731 1.3535 1.3419 0.0766 61.08 rs7653685 Genotyped C DOMINANT 0.003653 0.1786 1.4802 1.4969 0.0084 79.08 rs7684899 Imputed C DOMINANT 9.54E−05 9.54E−05 0.6466 0.6466 0.5013 0 rs7701604 Imputed G ADDITIVE 0.008373 0.1243 0.5451 0.3771 0.0037 82.12 rs7701604 Imputed G DOMINANT 0.0151 0.1693 0.5356 0.3959 0.0036 82.2 rs7703676 Imputed C ADDITIVE 0.008373 0.1243 0.5451 0.3771 0.0037 82.12 rs7703676 Imputed C DOMINANT 0.0151 0.1693 0.5356 0.3959 0.0036 82.2 rs7711358 Imputed A DOMINANT 6.11E−07 6.11E−07 0.5846 0.5846 0.9519 0 rs7713251 Imputed C RECESSIVE 0.0004673 0.01381 1.817 1.8103 0.1436 48.48 rs7737608 Imputed G DOMINANT 0.004374 0.3589 1.3752 1.2994 0.0019 83.98 rs7755903 Imputed A GENOTYPIC 0.000545 0.01934 0.5737 0.5711 0.1208 52.69 rs7762993 Imputed A ADDITIVE 0.0001907 0.02185 1.4428 1.3966 0.1265 51.63 rs7762993 Imputed A DOMINANT 5.98E−05 0.0279 1.5641 1.5155 0.0621 64.02 rs7767265 Imputed G DOMINANT 1.02E−05 0.01409 1.6165 1.5706 0.0624 63.96 rs7769415 Imputed C GENOTYPIC 8.18E−05 8.18E−05 2.0029 2.0029 0.4259 0 rs7771264 Imputed T DOMINANT 0.001814 0.07578 0.7128 0.7164 0.055 65.53 rs7795792 Imputed T RECESSIVE 8.16E−05 8.16E−05 0.5849 0.5849 0.3771 0 rs7806481 Imputed G RECESSIVE 0.01058 0.4116 0.7116 0.7366 0.0005 86.94 rs7808536 Imputed G DOMINANT 8.83E−05 8.83E−05 1.5445 1.5445 0.4545 0 rs7814819 Imputed G ADDITIVE 1.73E−05 1.73E−05 2.1934 2.1934 0.7688 0 rs7814819 Imputed G DOMINANT 5.48E−06 5.48E−06 2.3941 2.3941 0.8199 0 rs7815952 Imputed T DOMINANT 0.0001667 0.007582 2.0855 2.0402 0.1794 41.79 rs7834090 Imputed T DOMINANT 0.0001667 0.007582 2.0855 2.0402 0.1794 41.79 rs7859250 Imputed C DOMINANT 0.002865 0.1511 0.6526 0.6624 0.0221 73.76 rs7863577 Genotyped A ADDITIVE 0.001489 0.09537 0.6564 0.6635 0.037 69.66 rs7863577 Genotyped A DOMINANT 0.0007401 0.03086 0.6143 0.6263 0.1159 53.59 rs7902140 Imputed C ADDITIVE 0.0004487 0.01039 0.7037 0.7112 0.1881 40.15 rs7921834 Imputed C DOMINANT 5.72E−05 5.72E−05 1.5321 1.5321 0.4195 0 rs7939893 Imputed C ADDITIVE 6.01E−05 6.01E−05 0.7308 0.7308 0.6443 0 rs7939893 Imputed C DOMINANT 2.83E−06 2.83E−06 0.607 0.607 0.54 0 rs7955901 Imputed C ADDITIVE 4.86E−05 4.86E−05 0.7344 0.7344 0.959 0 rs7955901 Imputed C DOMINANT 2.65E−05 2.65E−05 0.617 0.617 0.71 0 rs7956274 Imputed T ADDITIVE 5.90E−05 5.90E−05 0.7346 0.7346 0.9732 0 rs7956274 Imputed T DOMINANT 3.36E−05 3.36E−05 0.6194 0.6194 0.7678 0 rs7957932 Imputed G ADDITIVE 7.64E−05 7.64E−05 0.7393 0.7393 0.9682 0 rs7957932 Imputed G DOMINANT 1.49E−05 1.49E−05 0.604 0.604 0.7593 0 rs7984294 Imputed A DOMINANT 9.75E−05 9.75E−05 1.7346 1.7346 0.5063 0 rs7994286 Imputed A ADDITIVE 0.07908 0.6072 0.8008 0.8163 0.0001 89.29 rs7994286 Imputed A DOMINANT 0.08583 0.5854 0.7921 0.7921 0.0001 89.54 rs8038229 Genotyped A ADDITIVE 6.08E−05 9.60E−05 0.7204 0.7188 0.3455 5.89 rs8038229 Genotyped A DOMINANT 9.63E−05 9.63E−05 0.6627 0.6627 0.4576 0 rs8043336 Imputed C GENOTYPIC 0.00137 0.05581 0.5451 0.5279 0.0522 66.13 rs8043336 Imputed C RECESSIVE 0.001089 0.03846 0.5559 0.5432 0.0772 60.96 rs8054431 Imputed T DOMINANT 8.98E−05 0.00368 1.557 1.5551 0.1739 42.83 rs8066502 Imputed T DOMINANT 8.43E−05 8.43E−05 0.6277 0.6277 0.5424 0 rs8068714 Imputed T DOMINANT 8.71E−05 8.71E−05 0.6283 0.6283 0.5356 0 rs892575 Imputed T ADDITIVE 0.0003596 0.01472 1.3576 1.3374 0.1542 46.51 rs892583 Imputed G ADDITIVE 0.0002367 0.004322 1.3734 1.3595 0.2211 33.74 rs915494 Imputed A ADDITIVE 5.04E−05 5.04E−05 1.401 1.401 0.4759 0 rs915494 Imputed A DOMINANT 1.99E−05 7.05E−05 1.5873 1.5804 0.3261 10.76 rs917295 Imputed G DOMINANT 4.33E−07 4.33E−07 0.5808 0.5808 0.9574 0 rs922594 Imputed T DOMINANT 5.29E−05 5.29E−05 0.6483 0.6483 0.5564 0 rs9301653 Imputed T ADDITIVE 0.06224 0.577 0.7882 0.8017 0.0001 89.23 rs9301653 Imputed T DOMINANT 0.06057 0.5529 0.7739 0.7744 0.0001 89.62 rs9309988 Imputed G DOMINANT 0.003653 0.1786 1.4802 1.4969 0.0084 79.08 rs9309989 Genotyped C DOMINANT 0.005145 0.2346 1.4559 1.4701 0.0036 82.24 rs9310221 Imputed A DOMINANT 0.0004892 0.152 1.5136 1.4374 0.0126 77.16 rs9327555 Imputed T DOMINANT 4.20E−07 4.20E−07 0.5804 0.5804 0.9556 0 rs937890 Imputed G DOMINANT 6.84E−05 6.84E−05 0.6201 0.6201 0.5639 0 rs9454967 Imputed G ADDITIVE 0.000403 0.06626 1.6379 1.6775 0.0204 74.32 rs9454967 Imputed G DOMINANT 9.90E−05 0.06125 1.8091 1.8433 0.0126 77.13 rs9471295 Imputed T DOMINANT 5.22E−05 5.22E−05 1.6081 1.6081 0.834 0 rs9477007 Imputed A ADDITIVE 0.0006021 0.03371 1.2928 1.2761 0.1007 56.44 rs9477007 Imputed A GENOTYPIC 0.0002564 0.005808 1.7495 1.7219 0.1967 38.49 rs9487279 Imputed T DOMINANT 0.002105 0.09969 0.7072 0.7196 0.0492 66.8 rs949016 Imputed C ADDITIVE 0.0002405 0.007834 1.372 1.3542 0.1841 40.91 rs9555973 Imputed G ADDITIVE 0.07024 0.5911 0.7954 0.8108 0.0001 89 rs9555973 Imputed G DOMINANT 0.07631 0.5694 0.7863 0.7867 0.0001 89.22 rs9557510 Imputed G ADDITIVE 5.36E−05 5.36E−05 1.5231 1.5231 0.7181 0 rs9557510 Imputed G DOMINANT 4.27E−05 4.27E−05 1.6282 1.6282 0.5332 0 rs9560584 Imputed T DOMINANT 0.0887 0.5829 0.792 0.7896 0.0001 89.53 rs9588770 Imputed T DOMINANT 0.07854 0.5309 0.7885 0.772 0.0001 88.8 rs9588848 Imputed C ADDITIVE 0.06224 0.577 0.7882 0.8017 0.0001 89.23 rs9588848 Imputed C DOMINANT 0.06057 0.5529 0.7739 0.7744 0.0001 89.62 rs966583 Imputed A ADDITIVE 9.26E−05 9.26E−05 0.7367 0.7367 0.9674 0 rs966583 Imputed A DOMINANT 1.20E−05 1.20E−05 0.6161 0.6161 0.8284 0 rs974130 Genotyped A RECESSIVE 0.002277 0.101 1.5851 1.5579 0.0437 68.05 rs977160 Imputed T ADDITIVE 0.0002651 0.05569 1.3742 1.3339 0.0564 65.23 rs9812206 Imputed G ADDITIVE 5.56E−05 0.05202 0.5663 0.5775 0.0221 73.76 rs9812206 Imputed G DOMINANT 8.50E−05 0.05567 0.5652 0.5728 0.021 74.13 rs9813552 Imputed G ADDITIVE 9.05E−05 0.0567 0.5743 0.5799 0.0208 74.16 rs9813552 Imputed G DOMINANT 0.0001441 0.07188 0.5733 0.5795 0.0165 75.64 rs9815037 Imputed T ADDITIVE 7.92E−05 0.0586 0.5721 0.5786 0.0188 74.84 rs9815037 Imputed T DOMINANT 0.0001241 0.07373 0.5708 0.5779 0.0148 76.27 rs9825349 Imputed A ADDITIVE 7.92E−05 0.0586 0.5721 0.5786 0.0188 74.84 rs9825349 Imputed A DOMINANT 0.0001241 0.07373 0.5708 0.5779 0.0148 76.27 rs9834217 Imputed T ADDITIVE 6.37E−05 0.04695 0.5683 0.5735 0.024 73.19 rs9834217 Imputed T DOMINANT 9.99E−05 0.05997 0.5668 0.5725 0.0192 74.7 rs9840460 Imputed T ADDITIVE 6.24E−05 0.0469 0.5679 0.5732 0.0239 73.23 rs9840460 Imputed T DOMINANT 9.77E−05 0.05992 0.5664 0.5721 0.0191 74.75 rs9840756 Imputed A ADDITIVE 5.29E−05 0.04056 0.5646 0.5694 0.0275 72.18 rs9840756 Imputed A DOMINANT 8.32E−05 0.05269 0.563 0.5684 0.022 73.8 rs9844801 Imputed C DOMINANT 0.003653 0.1786 1.4802 1.4969 0.0084 79.08 rs985375 Imputed A GENOTYPIC 0.0005024 0.0184 2.1795 2.1225 0.1411 48.93 rs9869187 Imputed C ADDITIVE 0.0002129 0.05227 0.587 0.5974 0.0378 69.48 rs9869187 Imputed C DOMINANT 0.0005049 0.05719 0.5988 0.6038 0.0436 68.07 rs9872327 Imputed T DOMINANT 0.003653 0.1786 1.4802 1.4969 0.0084 79.08 rs9881685 Imputed A ADDITIVE 5.96E−05 0.0538 0.5653 0.5735 0.0205 74.27 rs9881685 Imputed A DOMINANT 8.36E−05 0.0568 0.5632 0.5683 0.0192 74.71 rs9909499 Imputed C DOMINANT 6.59E−05 6.59E−05 1.5349 1.5349 0.7556 0 rs9911847 Imputed G DOMINANT 6.59E−05 6.59E−05 0.6229 0.6229 0.5677 0 rs9946886 Imputed G RECESSIVE 5.84E−05 5.84E−05 0.3084 0.3084 0.8937 0 rs9958823 Imputed A ADDITIVE 0.0001257 0.005478 1.3904 1.3724 0.1829 41.13 rs9965248 Imputed T ADDITIVE 0.0006176 0.03664 1.3453 1.3168 0.1086 54.95

TABLE 14 PRA- PRA- PLA- PLA- PRA- PLA- VA_ PRA- VA_ CEBO_ PLA- CEBO_ VA_ CEBO_ A1_ VA_ A2_ A1_ CEBO_ A2_ AL- HW_ AL- AL- AL- HZ_ HET_ HZ_ HZ_ HET_ HZ_ SNP LELE MOD- PVA LELE_ LELE_ LELE_ CO- CO- CO- CO- CO- CO- rs # SOURCE (A1) EL NMISS OR SE L95 U95 STAT P LUE FREQ FREQ FREQ UNT UNT UNT UNT UNT UNT rs577638540 Geno- T DOM 800 0.3686 0.3223 0.196 0.6931 −3.097 0.001952 0.3047 0.0375 0.021008 0.05079 1 13 343 1 43 399 typed rs72746987 Geno- A DOM 800 0.3351 0.3134 0.1813 0.6195 −3.488 0.000487 1 0.04 0.019608 0.056433 0 14 343 1 48 394 typed rs10021016 Geno- G GEN 800 7.997 0.01834 0.8563 0.26563 0.294118 0.242664 35 140 182 20 175 248 typed rs10021016 Geno- G REC 800 2.242 0.2913 1.266 3.967 2.771 0.005589 0.8563 0.26563 0.294118 0.242664 35 140 182 20 175 248 typed rs10051148 Imputed C DOM 796 0.6544 0.1465 0.491 0.8722 −2.893 0.003813 0.8139 0.34296 0.315493 0.365079 44 136 175 51 220 170 rs10054055 Imputed T DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.9376 0.345 0.317927 0.366817 44 139 174 52 221 170 rs10067895 Imputed A DOM 791 0.6716 0.1473 0.5032 0.8964 −2.703 0.006874 0.6933 0.34324 0.316901 0.364679 44 137 174 52 214 170 rs10100725 Imputed C DOM 800 0.5483 0.1594 0.4011 0.7494 −3.769 0.000164 0.2765 0.17813 0.141457 0.207675 12 77 268 18 148 277 rs10128531 Imputed T ADD 742 1.482 0.1557 1.092 2.011 2.526 0.01154 0.7542 0.13612 0.159159 0.117359 7 92 234 5 86 318 rs10181743 Imputed G ADD 762 1.488 0.1083 1.204 1.84 3.673 0.00024 0.5529 0.42126 0.473837 0.37799 72 182 90 59 198 161 rs10199127 Imputed T DOM 780 1.486 0.1462 1.116 1.98 2.712 0.006692 0.4327 0.28846 0.315714 0.266279 28 165 157 32 165 233 rs10270624 Imputed G DOM 750 1.438 0.1529 1.066 1.94 2.375 0.01754 0.5731 0.20333 0.224036 0.186441 11 129 197 17 120 276 rs1030006 Imputed G REC 797 1.663 0.1726 1.186 2.333 2.947 0.003209 0.8313 0.46926 0.495775 0.447964 96 160 99 81 234 127 rs1031811 Imputed A REC 792 1.684 0.2618 1.008 2.813 1.991 0.04646 0.5994 0.2822 0.291785 0.274487 37 132 184 29 183 227 rs10430870 Geno- G GEN 800 8.659 0.01317 0.1303 0.24938 0.282913 0.222348 36 130 191 22 153 268 typed rs10430870 Geno- G REC 800 2.178 0.2884 1.237 3.833 2.698 0.006973 0.1303 0.24938 0.282913 0.222348 36 130 191 22 153 268 typed rs10469597 Imputed A GEN 739 11.61 0.003011 0.04142 0.27267 0.308735 0.243243 43 119 170 23 152 232 rs10469597 Imputed A REC 739 2.519 0.2716 1.479 4.289 3.401 0.00067 0.04142 0.27267 0.308735 0.243243 43 119 170 23 152 232 rs10478919 Imputed G DOM 797 0.6489 0.1462 0.4872 0.8644 −2.957 0.003109 0.7533 0.34316 0.314607 0.366213 44 136 176 52 219 170 rs10506623 Imputed C ADD 777 0.7349 0.1071 0.5957 0.9066 −2.875 0.004041 1 0.39961 0.362069 0.43007 50 152 146 74 221 134 rs10506623 Imputed C DOM 777 0.6128 0.1531 0.454 0.8273 −3.199 0.001381 1 0.39961 0.362069 0.43007 50 152 146 74 221 134 rs10506626 Imputed A ADD 795 0.7463 0.105 0.6075 0.9169 −2.786 0.005339 0.8818 0.39308 0.356742 0.422551 53 148 155 71 229 139 rs10506626 Imputed A DOM 795 0.5922 0.1495 0.4418 0.7938 −3.504 0.000458 0.8818 0.39308 0.356742 0.422551 53 148 155 71 229 139 rs10509477 Imputed T DOM 800 1.654 0.1456 1.243 2.2 3.456 0.000547 0.9326 0.29688 0.329132 0.27088 31 173 153 40 160 243 rs10517918 Imported G REC 798 1.697 0.1851 1.181 2.439 2.858 0.004265 0.7175 0.42669 0.460674 0.399321 81 166 109 67 219 156 rs10517924 Imputed A REC 800 1.803 0.1754 1.279 2.543 3.362 0.000773 0.4338 0.45625 0.488796 0.430023 96 157 104 76 229 138 rs10519362 Imputed G DOM 784 1.5 0.1539 1.109 2.028 2.634 0.00844 1 0.17985 0.201705 0.162037 9 124 219 16 108 308 rs10520072 Imputed T DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.8149 0.34563 0.317927 0.367946 44 139 174 53 220 170 rs10737390 Imputed T DOM 787 0.5772 0.1513 0.4291 0.7764 −3.632 0.000281 0.7109 0.40089 0.365819 0.429561 58 143 153 71 230 132 rs10742851 Imputed T REC 800 0.406 0.2924 0.2289 0.7202 −3.083 0.002051 1 0.29 0.268908 0.306998 17 158 182 50 172 221 rs10743685 Imputed G GEN 795 12.35 0.002076 0.1392 0.39937 0.443662 0.363636 79 157 119 58 204 178 rs10743685 Imputed G REC 795 1.943 0.1919 1.334 2.831 3.462 0.000536 0.1392 0.39937 0.443662 0.363636 79 157 119 58 204 178 rs10749293 Imputed G DOM 797 1.637 0.1456 1.231 2.178 3.387 0.000706 0.8656 0.29674 0.328652 0.270975 31 172 153 40 159 242 rs10749294 Imputed A DOM 798 1.575 0.1455 1.184 2.095 3.123 0.00179 0.7216 0.27256 0.300562 0.25 24 166 166 33 155 254 rs10753760 Imputed T ADD 745 1.391 0.1067 1.128 1.715 3.093 0.001984 0.5446 0.4094 0.456061 0.372289 71 159 100 58 193 164 rs10753760 Imputed T GEN 745 9.763 0.007586 0.5446 0.4094 0.456061 0.372289 71 159 100 58 193 164 rs10772362 Imputed T ADD 800 0.6338 0.1259 0.4952 0.8112 −3.621 0.000293 0.2824 0.2375 0.194678 0.272009 7 125 225 32 177 234 rs10784891 Imputed C ADD 765 0.7164 0.1084 0.5792 0.886 −3.077 0.002092 0.3414 0.44575 0.404692 0.478774 54 168 119 91 224 109 rs10784891 Imputed C DOM 765 0.631 0.1608 0.4604 0.8648 −2.863 0.004193 0.3414 0.44575 0.404692 0.478774 54 168 119 91 224 109 rs10784891 Imputed C GEN 765 9.725 0.007731 0.3414 0.44575 0.404692 0.478774 54 168 119 91 224 109 rs10787923 Imputed G DOM 796 1.647 0.1457 1.238 2.191 3.425 0.000616 0.8652 0.29648 0.328652 0.270455 31 172 153 40 158 242 rs10787924 Imputed T DOM 797 1.585 0.1456 1.191 2.109 3.163 0.001564 0.7885 0.27227 0.300562 0.249433 24 166 166 33 154 254 rs10787949 Imputed A DOM 800 1.634 0.1456 1.228 2.173 3.373 0.000745 1 0.29688 0.330532 0.269752 32 172 153 38 163 242 rs10787951 Imputed G DOM 800 1.634 0.1456 1.228 2.173 3.373 0.000745 1 0.29688 0.330532 0.269752 32 172 153 38 163 242 rs10787983 Imputed C DOM 798 1.614 0.1449 1.215 2.144 3.304 0.000953 0.8644 0.29261 0.32493 0.26644 30 172 155 37 161 243 rs10794733 Imputed C ADD 786 0.765 0.1126 0.6135 0.9539 −2.379 0.01734 0.934 0.31361 0.2849 0.336782 31 138 182 47 199 189 rs10818280 Imputed C DOM 788 0.7042 0.1448 0.5302 0.9353 −2.422 0.01544 0.7332 0.29759 0.26204 0.326437 25 135 193 47 190 198 rs10860586 Imputed A ADD 796 1.322 0.1036 1.079 1.62 2.695 0.007028 0.8315 0.48995 0.523876 0.4625 97 179 80 92 223 125 rs10860586 Imputed A GEN 796 7.298 0.02602 0.8315 0.48995 0.523876 0.4625 97 179 80 92 223 125 rs10870473 Imputed A ADD 371 0.54 0.1831 0.3772 0.773 −3.366 0.000762 0.894 0.2655 0.207317 0.311594 7 54 103 18 93 96 rs10870473 Imputed A DOM 371 0.4734 0.2198 0.3077 0.7283 −3.402 0.000668 0.894 0.2655 0.207317 0.311594 7 54 103 18 93 96 rs10879240 Imputed C ADD 791 0.7324 0.1067 0.5942 0.9027 −2.92 0.003505 0.2791 0.43805 0.40085 0.468037 53 177 123 91 228 119 rs10879240 Imputed C GEN 791 8.522 0.0141 0.2791 0.43805 0.40085 0.468037 53 177 123 91 228 119 rs10879242 Imputed A ADD 793 0.741 0.1058 0.6022 0.9117 −2.834 0.0046 0.941 0.40038 0.364789 0.429224 52 155 148 74 228 136 rs10879242 Imputed A DOM 793 0.6085 0.1511 0.4525 0.8182 −3.288 0.00101 0.941 0.40038 0.364789 0.429224 52 155 148 74 228 136 rs10879245 Imputed G ADD 793 0.741 0.1058 0.6022 0.9117 −2.834 0.0046 0.941 0.40038 0.364789 0.429224 52 155 148 74 228 136 rs10879245 Imputed G DOM 793 0.6085 0.1511 0.4525 0.8182 −3.288 0.00101 0.941 0.40038 0.364789 0.429224 52 155 148 74 228 136 rs10879249 Imputed T ADD 795 0.7264 0.1064 0.5897 0.8947 −3.006 0.00265 1 0.3956 0.357746 0.426136 50 154 151 74 227 139 rs10879249 Imputed T DOM 795 0.6001 0.151 0.4464 0.8068 −3.382 0.00072 1 0.3956 0.357746 0.426136 50 154 151 74 227 139 rs10886429 Imputed A DOM 797 1.634 0.1459 1.228 2.175 3.365 0.000766 0.9325 0.29737 0.328652 0.272109 31 172 153 40 160 241 rs10886449 Imputed G DOM 800 1.594 0.145 1.2 2.119 3.217 0.001297 0.7887 0.27188 0.302521 0.247178 25 166 166 32 155 256 rs10886451 Imputed G DOM 800 1.594 0.145 1.2 2.119 3.217 0.001297 0.7887 0.27188 0.302521 0.247178 25 166 166 32 155 256 rs10886452 Imputed A DOM 800 1.634 0.1456 1.228 2.173 3.373 0.000745 1 0.29688 0.330532 0.269752 32 172 153 38 163 242 rs10886456 Imputed G DOM 800 1.594 0.145 1.2 2.119 3.217 0.001297 7.89E−01 0.27188 0.302521 0.247178 25 166 166 32 155 256 rs10886463 Imputed C DOM 800 1.624 0.1458 1.221 2.162 3.327 0.000878 0.9328 0.29875 0.330532 0.273138 32 172 153 40 162 241 rs10886465 Imputed A DOM 800 1.664 0.1454 1.251 2.212 3.503 0.000461 1 0.295 0.329132 0.267494 31 173 153 38 161 244 rs10886526 Imputed C DOM 798 1.614 0.1449 1.215 2.144 3.304 0.000953 0.8644 0.29261 0.32493 0.26644 30 172 155 37 161 243 rs10922903 Imputed C REC 800 0.4885 0.1995 0.3304 0.7222 −3.591 0.000329 0.8845 0.41813 0.37535 0.452596 44 180 133 97 207 139 rs10941126 Imputed G ADD 800 0.2198 0.3906 0.1022 0.4726 −3.878 0.000105 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs10941126 Imputed G DOM 800 0.2258 0.4052 0.102 0.4995 −3.673 0.00024 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs10947980 Imputed G ADD 798 0.7397 0.1176 0.5875 0.9314 −2.564 0.01033 0.7851 0.26504 0.232493 0.291383 19 128 210 35 187 219 rs11059376 Imputed T ADD 720 1.559 0.1386 1.188 2.045 3.203 0.001362 0.8067 0.18681 0.222741 0.157895 16 111 194 10 106 283 rs11072995 Imputed T GEN 793 9.167 0.01022 0.9062 0.18474 0.210452 0.164009 19 111 224 7 130 302 rs11072995 Imputed T REC 793 3.578 0.4502 1.481 8.646 2.832 0.004626 0.9062 0.18474 0.210452 0.164009 19 111 224 7 130 302 rs11081202 Geno- G GEN 800 7.034 0.02969 0.04263 0.29875 0.305322 0.293454 35 148 174 24 212 207 typed rs11081202 Geno- G REC 800 1.887 0.2769 1.097 3.248 2.294 0.0218 0.04263 0.29875 0.305322 0.293454 35 148 174 24 212 207 typed rs110965 Imputed C GEN 737 5.271 0.07169 0.4545 0.33175 0.354545 0.313268 44 146 140 32 191 184 rs11124962 Imputed A DOM 790 1.469 0.1461 1.103 1.956 2.63 0.008532 0.00528 0.23418 0.26204 0.21167 15 155 183 14 157 266 rs1116596 Imputed T DOM 794 0.6531 0.1466 0.49 0.8704 −2.907 0.003646 0.8136 0.34446 0.316384 0.367045 44 136 174 52 219 169 rs11178531 Imputed A ADD 796 0.7599 0.1049 0.6187 0.9334 −2.618 0.008858 0.4338 0.46734 0.432394 0.495465 68 171 116 100 237 104 rs11178531 Imputed A DOM 796 0.6258 0.1604 0.4569 0.857 −2.922 0.003477 0.4338 0.46734 0.432394 0.495465 68 171 116 100 237 104 rs11178583 Imputed A ADD 796 0.7274 0.1063 0.5906 0.896 −2.993 0.002762 0.9411 0.39573 0.358146 0.426136 50 155 151 74 227 139 rs11178583 Imputed A DOM 796 0.6032 0.1509 0.4488 0.8108 −3.35 0.000809 0.9411 0.39573 0.358146 0.426136 50 155 151 74 227 139 rs11178589 Imputed T ADD 787 0.7243 0.1059 0.5885 0.8915 −3.044 0.002334 0.9413 0.40915 0.368946 0.441514 52 155 144 79 227 130 rs11178589 Imputed T DOM 787 0.5988 0.1526 0.444 0.8075 −3.362 0.000775 0.9413 0.40915 0.368946 0.441514 52 155 144 79 227 130 rs11178594 Imputed C ADD 797 0.7305 0.1059 0.5936 0.8991 −2.964 0.003033 1 0.39837 0.360563 0.428733 51 154 150 75 229 138 rs11178594 Imputed C DOM 797 0.5995 0.1509 0.446 0.8058 −3.391 0.000696 1 0.39837 0.360563 0.428733 51 154 150 75 229 138 rs11178602 Imputed T ADD 795 0.7265 0.1059 0.5904 0.8941 −3.018 0.002545 0.9411 0.39748 0.358757 0.428571 51 152 151 75 228 138 rs11178602 Imputed T DOM 795 0.592 0.1508 0.4405 0.7956 −3.476 0.00051 0.9411 0.39748 0.358757 0.428571 51 152 151 75 228 138 rs11178648 Imputed T ADD 794 0.7481 0.1053 0.6086 0.9195 −2.757 0.00584 0.9407 0.39232 0.356338 0.421412 53 147 155 70 230 139 rs11178648 Imputed T DOM 794 0.5905 0.1497 0.4403 0.7918 −3.52 0.000432 0.9407 0.39232 0.356338 0.421412 53 147 155 70 230 139 rs11198877 Imputed T DOM 800 1.634 0.1456 1.228 2.173 3.373 0.000745 1 0.29688 0.330532 0.269752 32 172 153 38 163 242 rs11198942 Imputed T DOM 800 1.654 0.1456 1.243 2.2 3.456 0.000547 0.9326 0.29688 0.329132 0.27088 31 173 153 40 160 243 rs11221075 Imputed A ADD 725 0.6446 0.1613 0.4698 0.8842 −2.723 0.006476 0.2665 0.13586 0.107256 0.158088 2 64 251 15 99 294 rs11242020 Imputed T DOM 798 0.6462 0.1462 0.4852 0.8606 −2.987 0.002819 0.754 0.34336 0.314607 0.366516 44 136 176 52 220 170 rs11242021 Imputed T DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.7549 0.34625 0.317927 0.369074 44 139 174 54 219 170 rs11242022 Imputed T DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.7549 0.34625 0.317927 0.369074 44 139 174 54 219 170 rs11242023 Imputed T DOM 795 0.6676 0.1469 0.5005 0.8904 −2.75 0.00596 0.7538 0.34403 0.317416 0.365604 44 138 174 52 217 170 rs1149349 Imputed T DOM 798 1.696 0.1575 1.245 2.309 3.352 0.000802 0.6129 0.16729 0.19888 0.141723 11 120 226 9 107 325 rs1149350 Imputed A ADD 789 1.592 0.131 1.232 2.058 3.552 0.000383 0.3353 0.21103 0.249288 0.180365 17 141 193 13 132 293 rs1149350 Imputed A DOM 789 1.701 0.1501 1.267 2.282 3.539 0.000401 0.3353 0.21103 0.249288 0.180365 17 141 193 13 132 293 rs11576627 Imputed T ADD 800 1.72 0.1612 1.254 2.358 3.364 0.000769 0.04851 0.12313 0.154062 0.098194 3 104 250 3 81 359 rs11576627 Imputed T DOM 800 1.805 0.1683 1.298 2.51 3.508 0.000451 0.04851 0.12313 0.154062 0.098194 3 104 250 3 81 359 rs11630050 Imputed G GEN 778 8.696 0.01294 1 0.20373 0.227666 0.184455 22 114 211 10 139 282 rs11630050 Imputed G REC 778 3.097 0.3961 1.425 6.731 2.854 0.004317 1 0.20373 0.227666 0.184455 22 114 211 10 139 282 rs11633024 Imputed C GEN 778 8.696 0.01294 1 0.20373 0.227666 0.184455 22 114 211 10 139 282 rs11633024 Imputed C REC 778 3.097 0.3961 1.425 6.731 2.854 0.004317 1 0.20373 0.227666 0.184455 22 114 211 10 139 282 rs11636298 Imputed G GEN 800 9.499 0.008657 0.9089 0.19125 0.217087 0.170429 20 115 222 8 135 300 rs11636298 Imputed G REC 800 3.433 0.4298 1.478 7.972 2.87 0.004111 0.9089 0.19125 0.217087 0.170429 20 115 222 8 135 300 rs11637363 Imputed C GEN 774 9.788 0.007493 1 0.20607 0.231778 0.185615 23 113 207 10 140 281 rs11637363 Imputed C REC 774 3.309 0.3942 1.528 7.166 3.035 0.002402 1 0.20607 0.231778 0.185615 23 113 207 10 140 281 rs11637813 Imputed A GEN 778 8.696 0.01294 1 0.20373 0.227666 0.184455 22 114 211 10 139 282 rs11637813 Imputed A REC 778 3.097 0.3961 1.425 6.731 2.854 0.004317 1 0.20373 0.227666 0.184455 22 114 211 10 139 282 rs11638043 Imputed C GEN 777 8.808 0.01223 0.9134 0.20785 0.232558 0.188222 23 114 207 11 141 281 rs11638043 Imputed C REC 777 2.984 0.3815 1.413 6.303 2.866 0.00416 0.9134 0.20785 0.232558 0.188222 23 114 207 11 141 281 rs11638115 Imputed A GEN 793 9.167 0.01022 0.9062 0.18474 0.210452 0.164009 19 111 224 7 130 302 rs11638115 Imputed A REC 793 3.578 0.4502 1.481 8.646 2.832 0.004626 0.9062 0.18474 0.210452 0.164009 19 111 224 7 130 302 rs11638444 Imputed C GEN 799 9.274 0.009687 0.8201 0.19149 0.217087 0.170814 20 115 222 8 135 299 rs11717157 Imputed T ADD 800 1.366 0.1079 1.105 1.688 2.889 0.00386 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs11717157 Imputed T GEN 800 9.972 0.006832 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs11724055 Imputed A DOM 798 0.6341 0.1569 0.4662 0.8624 −2.903 0.003694 0.2128 0.17043 0.140845 0.194131 6 88 261 12 148 283 rs11743355 Imputed C ADD 732 0.2056 0.4133 0.0915 0.4623 −3.827 0.00013 0.01351 0.03689 0.01548 0.05379 0 10 313 4 36 369 rs11743355 Imputed C DOM 732 0.2102 0.4294 0.0906 0.4878 −3.632 0.000282 0.01351 0.03689 0.01548 0.05379 0 10 313 4 36 369 rs11746806 Imputed T ADD 800 0.2198 0.3906 0.1022 0.4726 −3.878 0.000105 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs11746806 Imputed t DOM 800 0.2258 0.4052 0.102 0.4995 −3.673 0.00024 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs11746959 Imputed T ADD 800 0.2198 0.3906 0.1022 0.4726 −3.878 0.000105 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs11746959 Imputed T DOM 800 0.2258 0.4052 0.102 0.4995 −3.673 0.00024 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs11749272 Imputed T DOM 797 0.6489 0.1462 0.4872 0.8644 −2.957 0.003109 0.7533 0.34316 0.314607 0.366213 44 136 176 52 219 170 rs11839636 Imputed C GEN 789 12.4 0.002029 0.3879 0.29087 0.336158 0.254023 42 154 158 30 161 244 rs11839785 Imputed C GEN 782 12.37 0.002065 0.2578 0.289 0.334758 0.25174 42 151 158 30 157 244 rs11853619 Imputed C GEN 799 9.423 0.008993 0.9088 0.19086 0.217087 0.169683 20 115 222 8 134 300 rs11853619 Imputed C REC 799 3.396 0.4296 1.463 7.882 2.846 0.004433 0.9088 0.19086 0.217087 0.169683 20 115 222 8 134 300 rs11856780 Imputed A GEN 799 9.423 0.008993 0.9088 0.19086 0.217087 0.169683 20 115 222 8 134 300 rs11856780 Imputed A REC 799 3.396 0.4296 1.463 7.882 2.846 0.004433 0.9088 0.19086 0.217087 0.169683 20 115 222 8 134 300 rs11901899 Imputed A DOM 767 1.388 0.1476 1.039 1.853 2.22 0.02644 0.4548 0.26206 0.288406 0.240521 24 151 170 24 155 243 rs11903290 Imputed C REC 793 1.68 0.2618 1.006 2.807 1.982 0.04748 0.598 0.28121 0.29096 0.273349 37 132 185 29 182 228 rs11909480 Imputed G ADD 797 0.3557 0.3375 0.1836 0.6892 −3.063 0.00219 0.591 0.03325 0.016854 0.046485 0 12 344 1 39 401 rs11909480 Imputed G DOM 797 0.3552 0.3405 0.1822 0.6924 −3.04 0.002368 0.591 0.03325 0.016854 0.046485 0 12 344 1 39 401 rs11910289 Imputed T ADD 765 1.705 0.2347 1.077 2.702 2.274 0.02295 1 0.05556 0.070175 0.043735 1 46 295 1 35 387 rs11910289 Imputed T DOM 765 1.77 0.2428 1.1 2.848 2.351 0.01871 1 0.05556 0.070175 0.043735 1 46 295 1 35 387 rs11920375 Geno- C GEN 800 10.36 0.005635 0.9394 0.3675 0.407563 0.335214 63 165 129 44 209 190 typed rs11926319 Imputed G DOM 799 0.5553 0.1951 0.3788 0.8139 −3.015 0.002567 0.6789 0.09449 0.071429 0.113122 3 45 309 5 90 347 rs11933744 Imputed T REC 799 2.427 0.2805 1.401 4.206 3.162 0.001567 1 0.27722 0.30112 0.257919 39 137 181 22 184 236 rs11934919 Imputed C REC 799 2.427 0.2805 1.401 4.206 3.162 0.001567 1 0.27722 0.30112 0.257919 39 137 181 22 184 236 rs11934957 Imputed C REC 799 2.427 0.2805 1.401 4.206 3.162 0.001567 1 0.27722 0.30112 0.257919 39 137 181 22 184 236 rs11959206 Imputed A REC 795 0.528 0.177 0.3733 0.7469 −3.609 0.000307 1 0.48805 0.44051 0.526018 62 187 104 127 211 104 rs12038613 Imputed C REC 783 0.4896 0.2003 0.3306 0.7249 −3.566 0.000363 0.9417 0.42209 0.376791 0.458525 44 175 130 96 206 132 rs12151417 Imputed T DOM 763 1.463 0.1495 1.091 1.961 2.545 0.01093 0.7585 0.2287 0.255814 0.206444 19 138 187 19 135 265 rs12153185 Imputed T DOM 792 0.6694 0.1472 0.5016 0.8933 −2.726 0.006403 0.6938 0.34343 0.316901 0.364989 44 137 174 52 215 170 rs12182651 Imputed T DOM 799 1.856 0.1976 1.26 2.734 3.131 0.001743 0.8332 0.09199 0.115169 0.073363 4 74 278 3 59 381 rs12235345 Imputed C DOM 793 2.195 0.2213 1.423 3.387 3.553 0.000382 0.3614 0.06368 0.086402 0.045455 0 61 292 1 38 401 rs12324786 Imputed T GEN 793 9.167 0.01022 0.9062 0.18474 0.210452 0.164009 19 111 224 7 130 302 rs12324786 Imputed T REC 793 3.578 0.4502 1.481 8.646 2.832 0.004626 0.9062 0.18474 0.210452 0.164009 19 111 224 7 130 302 rs12336958 Imputed G DOM 738 1.777 0.159 1.301 2.427 3.617 0.000298 0.2787 0.38821 0.428135 0.356448 49 182 96 55 183 173 rs12407412 Imputed C ADD 800 1.72 0.1612 1.254 2.358 3.364 0.000769 0.04851 0.12313 0.154062 0.098194 3 104 250 3 81 359 rs12407412 Imputed C DOM 800 1.805 0.1683 1.298 2.51 3.508 0.000451 0.04851 0.12313 0.154062 0.098194 3 104 250 3 81 359 rs12418971 Imputed C GEN 765 9.69 0.007866 0.1822 0.2549 0.290698 0.225653 36 128 180 21 148 252 rs12418971 Imputed C REC 765 2.279 0.2931 1.283 4.048 2.811 0.004945 0.1822 0.2549 0.290698 0.225653 36 128 180 21 148 252 rs1241967 Imputed T REC 798 0.3933 0.2549 0.2387 0.6482 −3.661 0.000252 0.2143 0.35088 0.308451 0.384876 23 173 159 67 207 169 rs12420184 Imputed G DOM 796 0.5503 0.165 0.3982 0.7604 −3.619 0.000295 0.5898 0.15515 0.125 0.179545 10 69 277 11 136 293 rs12433968 Imputed T DOM 762 0.5602 0.1482 0.419 0.749 −3.91 9.23−05 0.1676 0.29921 0.25 0.338863 20 130 190 40 206 176 rs12445477 Imputed A DOM 771 0.5609 0.2128 0.3696 0.8512 −2.717 0.006591 0.2176 0.07847 0.058997 0.09375 1 38 300 1 79 352 rs12447191 Geno- T ADD 800 0.6857 0.1355 0.5258 0.8943 −2.785 0.005354 0.8153 0.18625 0.159664 0.207675 5 104 248 21 142 280 typed rs12447191 Geno- T DOM 800 0.7141 0.1537 0.5284 0.9651 −2.191 0.02846 0.8153 0.18625 0.159664 0.207675 5 104 248 21 142 280 typed rs12465349 Imputed A REC 781 1.474 0.166 1.065 2.041 2.338 0.01938 0.3161 0.52369 0.555085 0.497658 108 177 69 99 227 101 rs1247340 Imputed C ADD 798 1.541 0.1317 1.191 1.995 3.286 0.001016 0.1597 0.20551 0.240169 0.177602 14 143 199 13 131 298 rs1247340 Imputed C DOM 798 1.679 0.1496 1.252 2.251 3.461 0.000538 0.1597 0.20551 0.240169 0.177602 14 143 199 13 131 298 rs1247341 Imputed C ADD 797 1.534 0.1317 1.185 1.986 3.248 0.001161 0.1917 0.20514 0.239437 0.177602 14 142 199 13 131 298 rs1247341 Imputed C DOM 797 1.668 0.1498 1.244 2.237 3.416 0.000635 0.1917 0.20514 0.239437 0.177602 14 142 199 13 131 298 rs1247343 Imputed C DOM 787 1.673 0.158 1.228 2.281 3.258 0.001121 0.6121 0.169 0.2 0.144165 11 118 221 9 108 320 rs12509758 Imputed C DOM 799 1.449 0.1495 1.081 1.942 2.48 0.01313 0.5762 0.19712 0.219101 0.179458 11 134 211 17 125 301 rs12515472 Imputed A DOM 799 1.337 0.1509 0.9948 1.798 1.925 0.0542 0.6528 0.19524 0.20927 0.183973 11 127 218 17 129 297 rs12548906 Imputed G ADD 761 1.308 0.1403 0.9936 1.722 1.914 0.05563 0.7959 0.16886 0.188235 0.153207 14 100 226 6 117 298 rs12596240 Imputed G DOM 800 0.5814 0.1491 0.434 0.7787 −3.637 0.000275 0.824 0.3925 0.348739 0.427765 49 151 157 76 227 140 rs12618781 Imputed A DOM 792 0.6189 0.1597 0.4526 0.8463 −3.005 0.002655 0.7209 0.46338 0.428977 0.490909 69 164 119 98 236 106 rs12678600 Imputed A DOM 800 0.6105 0.1458 0.4588 0.8125 −3.384 0.000715 0.5684 0.31813 0.280112 0.348758 30 140 187 47 215 181 rs12692229 Imputed T ADD 795 1.248 0.1075 1.011 1.541 2.063 0.03912 0.7574 0.35723 0.383853 0.335973 47 177 129 52 193 197 rs12713324 Imputed T DOM 779 1.464 0.1484 1.094 1.958 2.566 0.01029 0.8375 0.22465 0.252149 0.202326 19 138 192 19 136 275 rs12719415 Imputed T DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 4.86E−03 0.8149 0.34563 0.317927 0.367946 44 139 174 53 220 170 rs12820589 Imputed G ADD 757 1.483 0.1384 1.13 1.945 2.846 0.004422 0.07407 0.18758 0.219298 0.161446 12 126 204 7 120 288 rs12820589 Imputed G DOM 757 1.498 0.1543 1.107 2.028 2.621 0.008774 0.07407 0.18758 0.219298 0.161446 12 126 204 7 120 288 rs12831292 Imputed G ADD 788 0.73 0.1065 0.5925 0.8994 −2.955 0.003122 0.941 0.40102 0.362857 0.431507 51 152 147 75 228 135 rs12831292 Imputed G DOM 788 0.5953 0.1521 0.4418 0.802 −3.411 0.000647 0.941 0.40102 0.362857 0.431507 51 152 147 75 228 135 rs13012636 Imputed G REC 794 1.692 0.2617 1.013 2.827 2.01 0.04442 0.5987 0.28149 0.291785 0.273243 37 132 184 29 183 229 rs13038146 Imputed C ADD 800 1.353 0.1061 1.099 1.666 2.854 0.004317 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs13038146 Imputed C GEN 800 9.956 0.006888 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs13038146 Imputed C REC 800 1.892 0.2107 1.252 2.859 3.026 0.002474 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs13089860 Imputed A DOM 653 0.647 0.1731 0.4609 0.9083 −2.516 0.01188 5.01E−07 0.49617 0.446735 0.535912 72 116 103 121 146 95 rs13102419 Imputed T REC 779 1.798 0.1756 1.274 2.536 3.339 0.000841 0.3489 0.46213 0.494253 0.436195 96 152 100 77 222 132 rs13194907 Imputed A ADD 800 1.998 0.2096 1.325 3.013 3.302 0.00096 0.2635 0.06938 0.092437 0.05079 4 58 295 2 41 400 rs13194907 Imputed A DOM 800 2.076 0.2229 1.341 3.213 3.276 1.05E−03 0.2635 0.06938 0.092437 0.05079 4 58 295 2 41 400 rs13195745 Imputed A ADD 799 1.993 0.2097 1.322 3.006 3.29 0.001001 0.2638 0.06946 0.092437 0.050905 4 58 295 2 41 399 rs13195745 Imputed A DOM 799 2.07 0.223 1.337 3.204 3.263 0.001101 0.2638 0.06946 0.092437 0.050905 4 58 295 2 41 399 rs13265054 Imputed T DOM 798 0.6161 0.146 0.4628 0.8202 −3.318 0.000908 0.4633 0.3183 0.281513 0.348073 30 141 186 46 215 180 rs13273002 Imputed A GEN 798 12.57 0.001864 0.4182 0.22619 0.190141 0.255079 9 117 229 36 154 253 rs13282131 Imputed C ADD 797 1.33 0.1054 1.081 1.635 2.702 0.006897 0.5189 0.44668 0.480282 0.419683 82 177 96 72 227 143 rs13282131 Imputed C GEN 797 7.883 0.01942 0.5189 0.44668 0.480282 0.419683 82 177 96 72 227 143 rs13282131 Imputed C REC 797 1.605 0.1832 1.121 2.299 2.583 0.009794 0.5189 0.44668 0.480282 0.419683 82 177 96 72 227 143 rs1330052 Imputed G GEN 800 15.12 0.00052 0.2006 0.32813 0.379552 0.286682 52 167 138 42 170 231 rs1335721 Imputed A REC 783 0.4896 0.2003 0.3306 0.7249 −3.566 0.000363 0.9417 0.42209 0.376791 0.458525 44 175 130 96 206 132 rs1336382 Imputed T DOM 795 1.652 0.146 1.241 2.2 3.438 0.000587 0.8653 0.29686 0.328652 0.271071 31 172 153 40 158 241 rs1336383 Imputed T DOM 800 1.654 0.1456 1.243 2.2 3.456 0.000547 0.9326 0.29688 0.329132 0.27088 31 173 153 40 160 243 rs1336407 Imputed T DOM 800 1.62 0.1448 1.22 2.152 3.335 0.000854 0.9322 0.29313 0.32493 0.267494 30 172 155 38 161 244 rs1336409 Imputed T DOM 800 1.62 0.1448 1.22 2.152 3.335 0.000854 0.9322 0.29313 0.32493 0.267494 30 172 155 38 161 244 rs1336596 Imputed A DOM 796 0.5452 0.1487 0.4073 0.7298 −4.078 4.54E−05 0.3514 0.35239 0.312676 0.384354 45 132 178 60 219 162 rs13387284 Imputed A DOM 760 0.6185 0.1611 0.451 0.8482 −2.982 0.002863 0.8837 0.45526 0.420588 0.483333 65 156 119 91 224 105 rs13401462 Imputed C DOM 760 1.748 0.1697 1.254 2.438 3.292 0.000996 0.7164 0.47632 0.507396 0.451422 79 185 74 96 189 137 rs13409045 Imputed T ADD 792 0.7208 0.1088 0.5824 0.8921 −3.01 0.002612 0.5973 0.37942 0.338983 0.4121 40 160 154 70 221 147 rs1349284 Imputed C GEN 800 9.296 0.009578 0.7594 0.36125 0.397759 0.331828 60 164 133 42 210 191 rs1355715 Imputed T ADD 800 0.4791 0.2123 0.316 0.7263 −3.467 0.000527 0.6107 0.07375 0.047619 0.094808 1 32 324 4 76 363 rs1357696 Imputed A GEN 782 10.92 0.004251 0.5414 0.37404 0.411932 0.343023 63 164 125 42 211 177 rs1357698 Imputed A GEN 781 11.09 0.003915 0.5411 0.37452 0.413105 0.343023 63 164 124 42 211 177 rs1357699 Imputed T GEN 781 11.09 0.003915 0.5411 0.37452 0.413105 0.343023 63 164 124 42 211 177 rs1363273 Imputed C REC 780 0.5424 0.1801 0.3811 0.772 −3.397 0.000682 0.5195 0.48397 0.448276 0.512731 60 192 96 118 207 107 rs1373601 Imputed A DOM 731 0.6665 0.1502 0.4966 0.8946 −2.702 0.006895 0.3096 0.32216 0.286585 0.351117 32 124 172 50 183 170 rs1375829 Imputed C GEN 800 9.296 0.009578 0.7594 0.36125 0.397759 0.331828 60 164 133 42 210 191 rs1395748 Imputed G DOM 800 0.6151 0.1445 0.4634 0.8164 −3.364 0.000769 0.5437 0.285 0.239496 0.32167 19 133 205 42 201 200 rs1414865 Imputed T DOM 800 1.634 0.1456 1.228 2.173 3.373 0.000745 1 0.29688 0.330532 0.269752 32 172 153 38 163 242 rs1414873 Imputed A DOM 800 1.62 0.1448 1.22 2.152 3.335 0.000854 0.9322 0.29313 0.32493 0.267494 30 172 155 38 161 244 rs1414876 Imputed C DOM 800 1.62 0.1448 1.22 2.152 3.335 0.000854 0.9322 0.29313 0.32493 0.267494 30 172 155 38 161 244 rs1424643 Imputed G ADD 778 1.348 0.1253 1.054 1.723 2.38 0.0173 0.538 0.22494 0.252857 0.202103 18 141 191 18 137 273 rs1424643 Imputed G DOM 778 1.485 0.149 1.109 1.988 2.654 0.007946 0.538 0.22494 0.252857 0.202103 18 141 191 18 137 273 rs1424648 Imputed T DOM 784 1.357 0.1474 1.017 1.812 2.073 0.03819 0.4118 0.22449 0.248563 0.205275 18 137 193 17 145 274 rs1429321 Imputed A DOM 797 1.456 0.1473 1.091 1.943 2.549 0.01079 0.838 0.22208 0.2493 0.2 19 140 198 19 138 283 rs1429326 Imputed T ADD 792 1.336 0.1238 1.048 1.702 2.338 0.01941 0.8363 0.22033 0.247887 0.197941 18 140 197 19 135 283 rs1429326 Imputed T DOM 792 1.48 0.1477 1.108 1.977 2.653 0.007971 0.8363 0.22033 0.247887 0.197941 18 140 197 19 135 283 rs1444741 Imputed A DOM 728 0.6595 0.1504 0.4911 0.8857 −2.767 0.005653 0.3937 0.31868 0.282875 0.34788 31 123 173 48 183 170 rs1449916 Imputed C DOM 588 0.5892 0.1909 0.4052 0.8566 −2.771 0.005596 0.7419 0.4915 0.450368 0.526899 59 127 86 85 163 68 rs1459523 Imputed A ADD 800 1.366 0.1079 1.105 1.688 2.889 0.00386 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs1459523 Imputed A GEN 800 9.972 0.006832 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs1466352 Imputed T GEN 797 9.958 0.00688 0.821 0.37641 0.412676 0.347285 65 163 127 46 215 181 rs1466353 Imputed G GEN 796 10.02 0.006658 0.8212 0.37626 0.412429 0.347285 65 162 127 46 215 181 rs1476714 Imputed A DOM 797 0.6618 0.1469 0.4962 0.8826 −2.81 0.004957 0.8142 0.34567 0.31831 0.367647 44 138 173 53 219 170 rs1486723 Imputed C REC 800 0.4458 0.2394 0.2789 0.7127 −3.375 0.000739 0.8155 0.3475 0.315126 0.373589 28 169 160 70 191 182 rs1495375 Imputed A ADD 793 0.741 0.1058 0.6022 0.9117 −2.834 0.0046 0.941 0.40038 0.364789 0.429224 52 155 148 74 228 136 rs1495375 Imputed A DOM 793 0.6085 0.1511 0.4525 0.8182 −3.288 0.00101 0.941 0.40038 0.364789 0.429224 52 155 148 74 228 136 rs1495381 Imputed T GEN 799 8.222 0.01639 0.2696 0.40175 0.431373 0.377828 69 170 118 52 230 160 rs1495381 Imputed T REC 799 1.776 0.2004 1.199 2.631 2.867 0.004141 0.2696 0.40175 0.431373 0.377828 69 170 118 52 230 160 rs1498061 Imputed C ADD 385 0.4939 0.2066 0.3294 0.7405 −3.414 0.00064 0.07449 0.1961 0.144118 0.237209 3 43 124 6 90 119 rs1498992 Imputed G DOM 795 0.5981 0.1449 0.4502 0.7944 −3.549 0.000387 0.571 0.3239 0.280282 0.359091 33 133 189 54 208 178 rs1499001 Imputed T DOM 763 0.5667 0.1498 0.4225 0.76 −3.793 0.000149 0.5785 0.26606 0.218475 0.304502 18 113 210 39 179 204 rs1512988 Imputed A ADD 795 0.7274 0.1066 0.5903 0.8964 −2.987 0.002819 1 0.39371 0.355932 0.424036 49 154 151 74 226 141 rs1512988 Imputed A DOM 795 0.6077 0.151 0.452 0.817 −3.298 0.000973 1 0.39371 0.355932 0.424036 49 154 151 74 226 141 rs1512989 Imputed T ADD 795 0.7274 0.1066 0.5903 0.8964 −2.987 0.002819 1 0.39371 0.355932 0.424036 49 154 151 74 226 141 rs1512989 Imputed T DOM 795 0.6077 0.151 0.452 0.817 −3.298 0.000973 1 0.39371 0.355932 0.424036 49 154 151 74 226 141 rs1512991 Imputed T ADD 795 0.7286 0.1054 0.5926 0.8957 −3.005 0.002655 0.4324 0.46101 0.421127 0.493182 63 173 119 100 234 106 rs1512991 Imputed T DOM 795 0.6184 0.1596 0.4523 0.8456 −3.011 0.002605 0.4324 0.46101 0.421127 0.493182 63 173 119 100 234 106 rs1512991 Imputed T GEN 795 9.858 0.007235 0.4324 0.46101 0.421127 0.493182 63 173 119 100 234 106 rs1524303 Imputed T GEN 793 9.356 0.009296 0.7608 0.36948 0.407303 0.338673 62 166 128 44 208 185 rs1524306 Imputed C ADD 800 1.366 0.1079 1.105 1.688 2.889 0.00386 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs1524306 Imputed C GEN 800 9.972 0.006832 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs1524310 Imputed G ADD 800 1.366 0.1079 1.105 1.688 2.889 0.00386 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs1524310 Imputed G GEN 800 9.972 0.006832 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs1524321 Imputed C GEN 796 10.02 0.006673 0.8212 0.37626 0.412429 0.347285 65 162 127 46 215 181 rs1527059 Imputed A DOM 799 0.5689 0.2041 0.3813 0.8488 −2.763 0.005727 0.3612 0.08573 0.067416 0.100451 5 38 313 3 83 357 rs152707 Imputed A ADD 800 0.684 0.1058 0.5559 0.8415 −3.592 0.000328 0.6633 0.42063 0.372549 0.459368 45 176 136 93 221 129 rs152707 Imputed A GEN 800 13.34 0.001266 0.6633 0.42063 0.372549 0.459368 45 176 136 93 221 129 rs152712 Geno- C ADD 799 0.6783 0.106 0.5511 0.8349 −3.663 0.00025 0.5157 0.42553 0.376751 0.464932 45 179 133 95 221 126 typed rs152712 Geno- C GEN 799 14.09 0.00087 0.5157 0.42553 0.376751 0.464932 45 179 133 95 221 126 typed rs1533994 Imputed T GEN 799 10.31 0.005765 0.763 0.37484 0.411765 0.345023 65 164 128 45 215 182 rs1535866 Imputed G DOM 793 1.391 0.148 1.041 1.86 2.232 0.02564 0.9166 0.21564 0.239437 0.196347 18 134 203 18 136 284 rs1563773 Imputed T GEN 798 10.17 0.006179 0.7628 0.37531 0.411765 0.345805 65 164 128 45 215 181 rs1563774 Imputed T GEN 794 9.994 0.006759 0.5981 0.37846 0.414326 0.349315 65 165 126 45 216 177 rs1567740 Imputed T ADD 796 0.7274 0.1063 0.5906 0.896 −2.993 0.002762 0.9411 0.39573 0.358146 0.426136 50 155 151 74 227 139 rs1567740 Imputed T DOM 796 0.6032 0.1509 0.4488 0.8108 −3.35 0.000809 0.9411 0.39573 0.358146 0.426136 50 155 151 74 227 139 rs1572573 Imputed A DOM 770 1.748 0.1541 1.292 2.365 3.624 0.00029 0.5616 0.19221 0.22929 0.163194 15 125 198 16 109 307 rs1577497 Imputed C REC 786 0.4912 0.2002 0.3317 0.7272 −3.551 0.000384 0.9417 0.42112 0.377143 0.456422 44 176 130 96 206 134 rs1581514 Imputed T ADD 795 1.353 0.108 1.095 1.671 2.797 0.005152 0.5417 0.36541 0.403361 0.334475 60 168 129 42 209 187 rs1581514 Imputed T GEN 795 9.607 0.008202 0.5417 0.36541 0.403361 0.334475 60 168 129 42 209 187 rs1582321 Imputed T DOM 800 0.5814 0.1491 0.434 0.7787 −3.637 0.000275 0.824 0.3925 0.348739 0.427765 49 151 157 76 227 140 rs1582322 Imputed A DOM 799 0.5859 0.1493 0.4373 0.785 −3.581 0.000342 0.824 0.39299 0.351124 0.426637 50 150 156 75 228 140 rs1582323 Imputed A DOM 798 0.5825 0.1494 0.4346 0.7807 −3.617 0.000298 0.8238 0.39286 0.350704 0.426637 50 149 156 75 228 140 rs1592485 Imputed C DOM 799 0.5835 0.15 0.4349 0.7829 −3.592 0.000328 0.5061 0.39737 0.355742 0.430995 53 148 156 78 225 139 rs1600954 Imputed T ADD 759 1.379 0.106 1.12 1.697 3.029 0.002457 0.8845 0.48748 0.531343 0.45283 87 182 66 92 200 132 rs1600954 Imputed T GEN 759 11.97 0.002519 0.8845 0.48748 0.531343 0.45283 87 182 66 92 200 132 rs16938626 Imputed G DOM 797 0.612 0.1451 0.4605 0.8132 −3.385 0.000711 1 0.28043 0.24507 0.308824 26 122 207 36 201 205 rs16964300 Imputed G ADD 800 0.6771 0.135 0.5197 0.8821 −2.889 0.003862 0.9076 0.1875 0.159664 0.209932 5 104 248 22 142 279 rs16964300 Imputed G DOM 800 0.7073 0.1536 0.5234 0.9558 −2.254 0.02418 0.9076 0.1875 0.159664 0.209932 5 104 248 22 142 279 rs16986282 Imputed G DOM 800 0.3124 0.3551 0.1558 0.6267 −3.276 0.001053 0.5896 0.03313 0.016807 0.046275 1 10 346 0 41 402 rs17007620 Imputed G ADD 696 1.421 0.1303 1.101 1.834 2.696 0.007027 0.8349 0.23922 0.269868 0.215736 20 123 159 21 128 245 rs17007620 Imputed G DOM 696 1.572 0.1588 1.152 2.146 2.85 0.004376 0.8349 0.23922 0.269868 0.215736 20 123 159 21 128 245 rs17014326 Imputed G DOM 794 0.5837 0.145 0.4393 0.7755 −3.713 0.000205 0.7323 0.29408 0.246479 0.332574 22 131 202 44 204 191 rs17047957 Imputed C DOM 785 1.47 0.1535 1.088 1.986 2.51 0.01207 0.6344 0.1828 0.203704 0.165899 10 123 218 18 108 308 rs1705261 Imputed A REC 798 1.775 0.1989 1.202 2.622 2.885 0.003908 0.3391 0.40351 0.435393 0.377828 70 170 116 53 228 161 rs17073341 Imputed A ADD 800 2.568 0.2635 1.532 4.305 3.58 0.000344 1 0.04375 0.064426 0.027088 1 44 312 0 24 419 rs17073341 Imputed A DOM 800 2.569 0.2659 1.525 4.326 3.548 0.000388 1 0.04375 0.064426 0.027088 1 44 312 0 24 419 rs17138702 Imputed G ADD 797 0.5527 0.1573 0.406 0.7522 −3.77 0.000163 0.3509 0.13174 0.095506 0.160998 2 64 290 15 112 314 rs17189710 Imputed T ADD 795 1.359 0.1063 1.103 1.673 2.882 0.003957 0.3973 0.36038 0.40113 0.327664 64 156 134 45 199 197 rs17189710 Imputed T GEN 795 10.06 0.006549 0.3973 0.36038 0.40113 0.327664 64 156 134 45 199 197 rs17189710 Imputed T REC 795 1.896 0.2108 1.254 2.866 3.034 0.002411 0.3973 0.36038 0.40113 0.327664 64 156 134 45 199 197 rs17310176 Imputed T ADD 800 0.6381 0.1364 0.4884 0.8336 −3.294 0.000988 0.22 0.17375 0.138655 0.202032 10 79 268 19 141 283 rs17310176 Imputed T DOM 800 0.5794 0.1584 0.4248 0.7903 −3.446 0.00057 0.22 0.17375 0.138655 0.202032 10 79 268 19 141 283 rs17358860 Imputed A DOM 800 0.6291 0.1568 0.4626 0.8555 −2.955 0.003129 0.2583 0.17 0.140056 0.194131 6 88 263 12 148 283 rs17370541 Imputed T GEN 752 13.88 0.000967 0.3116 0.37434 0.426647 0.332536 67 151 116 45 188 185 rs17370541 Imputed T REC 752 2.075 0.2103 1.374 3.133 3.469 0.000522 0.3116 0.37434 0.426647 0.332536 67 151 116 45 188 185 rs17526574 Imputed G GEN 800 11.97 0.002516 0.2278 0.28875 0.333333 0.252822 43 152 162 31 162 250 rs17530747 Imputed T DOM 797 0.5794 0.1476 0.4338 0.7738 −3.698 0.000218 0.9395 0.36951 0.320225 0.409297 39 150 167 69 223 149 rs17649114 Imputed C DOM 800 1.543 0.1498 1.151 2.07 2.898 0.00376 0.5766 0.19625 0.22409 0.173815 13 134 210 15 124 304 rs17766172 Imputed A REC 770 0.3869 0.2703 0.2278 0.6573 −3.512 0.000444 0.3748 0.33571 0.324047 0.344988 20 181 140 61 174 194 rs1818885 Imputed G GEN 794 10.03 0.006649 0.5911 0.36146 0.400568 0.330317 59 164 129 41 210 191 rs1832222 Imputed G DOM 799 1.612 0.1449 1.214 2.142 3.295 0.000984 0.9321 0.29349 0.32493 0.2681 30 172 155 38 161 243 rs1861327 Imputed G DOM 800 0.5814 0.1491 0.434 0.7787 −3.637 0.000275 0.824 0.3925 0.348739 0.427765 49 151 157 76 227 140 rs1868581 Imputed G ADD 800 1.366 0.1079 1.105 1.688 2.889 0.00386 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs1868581 Imputed G GEN 800 9.972 0.006832 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs1874313 Imputed A ADD 797 0.7419 0.1059 0.6029 0.913 −2.819 0.004818 0.8824 0.3946 0.359155 0.423077 51 153 151 74 226 142 rs1874313 Imputed A DOM 797 0.615 0.1508 0.4577 0.8265 −3.224 0.001263 0.8824 0.3946 0.359155 0.423077 51 153 151 74 226 142 rs1876409 Imputed C DOM 800 0.6151 0.1445 0.4634 0.8164 −3.364 0.000769 0.5437 0.285 0.239496 0.32167 19 133 205 42 201 200 rs1913201 Imputed G ADD 771 0.7218 0.1078 0.5844 0.8916 −3.025 0.002485 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs1913201 Imputed G DOM 771 0.6464 0.1598 0.4726 0.8841 −2.731 0.006318 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs1913201 Imputed G GEN 771 9.268 0.009717 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs1916922 Imputed T GEN 800 9.972 0.006832 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs1936871 Geno- G DOM 800 0.571 0.1536 0.4226 0.7716 −3.647 0.000265 0.6638 0.42188 0.394958 0.443567 67 148 142 72 249 122 typed rs1961157 Imputed T REC 800 0.6068 0.1891 0.4189 0.8791 −2.642 0.00825 0.6171 0.45 0.413165 0.479684 55 185 117 103 219 121 rs1987179 Imputed T ADD 800 0.7138 0.1326 0.5504 0.9257 −2.542 0.01103 0.03097 0.20625 0.179272 0.227991 10 108 239 14 174 255 rs1987179 Imputed T DOM 800 0.6634 0.1489 0.4955 0.8883 −2.756 0.005859 0.03097 0.20625 0.179272 0.227991 10 108 239 14 174 255 rs1990023 Imputed T DOM 798 0.6462 0.1462 0.4852 0.8606 −2.987 0.002819 0.754 0.34336 0.314607 0.366516 44 136 176 52 220 170 rs1995025 Imputed C DOM 775 1.608 0.1638 1.167 2.217 2.901 0.003714 0.4655 0.14323 0.17192 0.119718 8 104 237 5 92 329 rs2016194 Imputed G DOM 799 0.6626 0.1466 0.4971 0.8832 −2.807 0.004996 0.8145 0.34543 0.317927 0.367647 44 139 174 53 219 170 rs2023651 Imputed T ADD 797 0.682 0.1247 0.5341 0.8707 −3.07 0.002139 0.1305 0.22773 0.191011 0.25737 14 108 234 35 157 249 rs2024902 Imputed A ADD 800 1.998 0.2096 1.325 3.013 3.302 0.00096 0.2635 0.06938 0.092437 0.05079 4 58 295 2 41 400 rs2024902 Imputed A DOM 800 2.076 0.2229 1.341 3.213 3.276 0.001053 0.2635 0.06938 0.092437 0.05079 4 58 295 2 41 400 rs2025107 Imputed A DOM 799 1.856 0.1976 1.26 2.734 3.131 0.001743 0.8332 0.09199 0.115169 0.073363 4 74 278 3 59 381 rs2025108 Imputed T DOM 799 1.856 0.1976 1.26 2.734 3.131 0.001743 0.8332 0.09199 0.115169 0.073363 4 74 278 3 59 381 rs2031987 Imputed T GEN 795 12.3 0.002134 0.2253 0.28616 0.331461 0.249431 42 152 162 30 159 250 rs2052428 Imputed C DOM 784 0.5903 0.1642 0.4279 0.8144 −3.21 0.001327 0.0995 0.46939 0.431818 0.5 67 170 115 94 244 94 rs2053230 Imputed C ADD 722 0.5414 0.1548 0.3998 0.7333 −3.964 7.36E−05 4.60E−06 0.18767 0.145511 0.221805 1 92 230 7 163 229 rs2062448 Imputed T DOM 788 0.5462 0.1963 0.3718 0.8024 −3.081 0.00206 0.1524 0.09708 0.072443 0.116972 4 43 305 7 88 341 rs2063420 Imputed C REC 780 1.755 0.1868 1.217 2.531 3.01 0.002608 0.8266 0.43013 0.464183 0.402552 81 162 106 65 217 149 rs2063591 Imputed C ADD 797 0.7519 0.1046 0.6125 0.9229 −2.727 0.006392 0.5698 0.47177 0.435211 0.501131 69 171 115 104 235 103 rs2063591 Imputed C DOM 797 0.6237 0.1609 0.4551 0.855 −2.934 0.003349 0.5698 0.47177 0.435211 0.501131 69 171 115 104 235 103 rs208026 Geno- A DOM 800 1.457 0.1466 1.093 1.941 2.565 0.01032 0.8428 0.23188 0.259104 0.209932 21 143 193 23 140 280 typed rs208029 Imputed T DOM 786 1.41 0.1496 1.052 1.891 2.298 0.02157 0.9177 0.22137 0.242165 0.204598 17 136 198 22 134 279 rs208757 Imputed G DOM 799 1.423 0.1463 1.068 1.895 2.411 0.01592 0.4251 0.22966 0.256303 0.208145 23 137 197 23 138 281 rs2095586 Imputed A DOM 785 1.655 0.1465 1.242 2.205 3.438 0.000586 0.8644 0.29745 0.331412 0.270548 30 170 147 38 161 239 rs2095606 Imputed A DOM 786 0.5466 0.1493 0.4079 0.7324 −4.046 5.20E−05 0.8151 0.35242 0.311966 0.385057 42 135 174 57 221 157 rs2102374 Imputed A ADD 790 0.6269 0.1219 0.4937 0.7961 −3.831 0.000128 0.781 0.25886 0.211429 0.296591 14 120 216 37 187 216 rs2102374 Imputed A DOM 790 0.5989 0.1465 0.4494 0.798 −3.501 0.000464 0.781 0.25886 0.211429 0.296591 14 120 216 37 187 216 rs2108426 Imputed C DOM 799 0.6626 0.1466 0.4971 0.8832 −2.807 0.004996 0.8145 0.34543 0.317927 0.367647 44 139 174 53 219 170 rs2110664 Imputed A DOM 744 1.429 0.1493 1.066 1.915 2.391 0.01682 0.5169 0.27218 0.300898 0.24878 26 149 159 25 154 231 rs2132242 Imputed A ADD 793 0.7317 0.1056 0.5948 0.9 −2.957 0.003104 0.8835 0.40984 0.371469 0.440774 53 157 144 79 229 131 rs2132242 Imputed A DOM 793 0.6043 0.1522 0.4484 0.8143 −3.309 0.000936 0.8835 0.40984 0.371469 0.440774 53 157 144 79 229 131 rs2158958 Imputed A DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.8149 0.34563 0.317927 0.367946 44 139 174 53 220 170 rs2158961 Imputed G DOM 796 0.6544 0.1465 0.491 0.8722 −2.893 0.003813 0.8139 0.34296 0.315493 0.365079 44 136 175 51 220 170 rs2163046 Imputed A DOM 775 1.474 0.149 1.101 1.973 2.603 0.009245 0.8374 0.22516 0.252874 0.202576 19 138 191 19 135 273 rs2180286 Imputed G DOM 798 0.6211 0.164 0.4503 0.8566 −2.903 0.003694 0.3579 0.49875 0.469188 0.522676 89 157 111 116 229 96 rs2180684 Imputed A DOM 800 1.684 0.1876 1.166 2.433 2.779 0.005451 0.05232 0.10313 0.120448 0.089165 5 76 276 9 61 373 rs2188079 Imputed C ADD 798 1.333 0.1034 1.088 1.632 2.775 0.005514 0.7718 0.42043 0.461972 0.387133 81 166 108 62 219 162 rs2188079 Imputed C GEN 798 10.2 0.006111 0.7718 0.42043 0.461972 0.387133 81 166 108 62 219 162 rs2190598 Imputed T DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.8149 0.34563 0.317927 0.367946 44 139 174 53 220 170 rs2190600 Imputed A DOM 791 0.6716 0.1473 0.5032 0.8964 −2.703 0.006874 0.6933 0.34324 0.316901 0.364679 44 137 174 52 214 170 rs2224184 Geno- T DOM 800 0.6357 0.1621 0.4626 0.8735 −2.794 0.005199 0.2036 0.495 0.466387 0.518059 89 155 113 116 227 100 typed rs2247066 Imputed A DOM 800 0.6151 0.1445 0.4634 0.8164 −3.364 0.000769 0.5437 0.285 0.239496 0.32167 19 133 205 42 201 200 rs2248236 Imputed C ADD 728 0.6377 0.1466 0.4784 0.85 −3.068 0.002153 0.1692 0.18063 0.147516 0.206897 6 83 233 12 144 250 rs2248236 Imputed C DOM 728 0.6049 0.1624 0.44 0.8317 −3.095 0.00197 0.1692 0.18063 0.147516 0.206897 6 83 233 12 144 250 rs2265733 Imputed C ADD 790 0.6269 0.1219 0.4937 0.7961 −3.831 0.000128 0.781 0.25886 0.211429 0.296591 14 120 216 37 187 216 rs2265733 Imputed C DOM 790 0.5989 0.1465 0.4494 0.798 −3.501 0.000464 0.781 0.25886 0.211429 0.296591 14 120 216 37 187 216 rs2270584 Imputed A ADD 796 0.7437 0.1051 0.6052 0.9138 −2.818 0.004834 0.8821 0.39322 0.356338 0.422902 53 147 155 71 231 139 rs2270584 Imputed A DOM 796 0.5859 0.1496 0.437 0.7855 −3.574 0.000351 0.8821 0.39322 0.356338 0.422902 53 147 155 71 231 139 rs2270586 Imputed A ADD 795 0.7444 0.1051 0.6059 0.9147 −2.808 0.004978 0.8818 0.39308 0.356338 0.422727 53 147 155 71 230 139 rs2270586 Imputed A DOM 795 0.5879 0.1496 0.4385 0.7883 −3.55 0.000385 0.8818 0.39308 0.356338 0.422727 53 147 155 71 230 139 rs229775 Imputed A REC 798 0.3933 0.2549 0.2387 0.6482 −3.661 0.000252 0.2143 0.35088 0.308451 0.384876 23 173 159 67 207 169 rs229815 Imputed T REC 762 0.4053 0.2727 0.2375 0.6916 −3.312 0.000925 0.1243 0.33727 0.297935 0.368794 20 162 157 57 198 168 rs229829 Imputed C REC 797 0.5066 0.2182 0.3303 0.7769 −3.117 0.001827 0.3711 0.38896 0.344633 0.424379 35 174 145 79 218 146 rs229831 Imputed A REC 797 0.3945 0.2549 0.2394 0.6501 −3.65 0.000263 0.2138 0.35132 0.309322 0.384876 23 173 158 67 207 169 rs2317057 Imputed T ADD 623 0.7125 0.1358 0.546 0.9298 −2.496 0.01256 0.3235 0.23917 0.20471 0.266571 14 85 177 26 133 188 rs2322100 Geno- T REC 800 1.768 0.28 1.021 3.061 2.035 0.04187 0.2233 0.28375 0.285714 0.282167 33 138 186 24 202 217 typed rs2322101 Imputed A REC 799 1.764 0.28 1.019 3.053 2.026 0.04276 0.2237 0.28348 0.285714 0.281674 33 138 186 24 201 217 rs2327929 Imputed G REC 799 1.996 0.1838 1.392 2.862 3.761 0.000169 0.09589 0.4224 0.470506 0.383747 89 157 110 65 210 168 rs2332844 Imputed A ADD 681 1.802 0.1484 1.347 2.41 3.969 7.22E−05 0.4407 0.81718 0.86526 0.77748 230 73 5 228 124 21 rs2332844 Imputed A REC 681 1.849 0.1698 1.326 2.579 3.62 0.000295 0.4407 0.81718 0.86526 0.77748 230 73 5 228 124 21 rs2349170 Imputed G DOM 797 1.638 0.1487 1.224 2.192 3.319 0.000903 0.1438 0.21706 0.245787 0.193878 12 151 193 18 135 288 rs2356722 Imputed G DOM 798 0.5863 0.1447 0.4416 0.7785 −3.691 0.000223 0.6103 0.29449 0.247191 0.332579 22 132 202 44 206 192 rs2364956 Imputed T ADD 772 1.439 0.1382 1.098 1.887 2.634 0.008429 1 0.16969 0.196581 0.147268 12 114 225 10 104 307 rs2373793 Imputed G ADD 792 1.379 0.1411 1.046 1.818 2.279 0.02264 0.1524 0.14583 0.169492 0.126712 12 96 246 10 91 337 rs2373793 Imputed G DOM 792 1.446 0.1627 1.051 1.989 2.265 0.0235 0.1524 0.14583 0.169492 0.126712 12 96 246 10 91 337 rs238252 Imputed G ADD 799 1.66 0.1458 1.248 2.209 3.478 0.000505 0.02096 0.13329 0.169468 0.104072 13 95 249 9 74 359 rs238252 Imputed G DOM 799 1.848 0.1687 1.328 2.573 3.642 0.000271 0.02096 0.13329 0.169468 0.104072 13 95 249 9 74 359 rs2383903 Imputed G DOM 797 0.6249 0.1456 0.4698 0.8313 −3.229 0.001242 0.9292 0.27478 0.240169 0.302721 24 123 209 35 197 209 rs2387945 Imputed G DOM 792 1.587 0.1626 1.154 2.182 2.84 0.004513 0.4666 0.14141 0.169014 0.118993 8 104 243 5 94 338 rs2389863 Imputed A DOM 784 0.6722 0.1503 0.5007 0.9025 −2.643 0.008221 0.03874 0.20791 0.181948 0.228736 10 107 232 14 171 250 rs2389866 Imputed C DOM 800 0.6634 0.1489 0.4955 0.8883 −2.756 0.005859 0.03097 0.20625 0.179272 0.227991 10 108 239 14 174 255 rs2389869 Imputed C DOM 800 0.6634 0.1489 0.4955 0.8883 −2.756 0.005859 0.03097 0.20625 0.179272 0.227991 10 108 239 14 174 255 rs2389870 Geno- C DOM 800 0.6413 0.1561 0.4723 0.8709 −2.846 0.004433 0.2661 0.1725 0.142857 0.196388 6 90 261 13 148 282 typed rs2418494 Imputed G ADD 777 0.8166 0.101 0.67 0.9953 −2.006 0.04483 0.06196 0.51351 0.485549 0.535963 84 168 94 134 194 103 rs2418494 Imputed G GEN 777 4.805 0.0905 0.06196 0.51351 0.485549 0.535963 84 168 94 134 194 103 rs2418541 Imputed A DOM 798 0.6462 0.1462 0.4852 0.8606 −2.987 0.002819 0.754 0.34336 0.314607 0.366516 44 136 176 52 220 170 rs2418542 Imputed A DOM 797 0.6489 0.1462 0.4872 0.8644 −2.957 0.003109 0.7533 0.34316 0.314607 0.366213 44 136 176 52 219 170 rs2423556 Imputed C DOM 796 0.6175 0.1654 0.4465 0.8539 −2.915 0.003556 0.3955 0.50251 0.473239 0.526077 90 156 109 117 230 94 rs2437688 Imputed C ADD 799 1.457 0.1639 1.056 2.008 2.294 0.02177 0.01205 0.10451 0.122191 0.090293 8 71 277 8 64 371 rs2456809 Imputed G DOM 800 0.6151 0.1445 0.4634 0.8164 −3.364 0.000769 0.604 0.28563 0.240896 0.32167 20 132 205 42 201 200 rs2456811 Imputed T ADD 789 0.6292 0.1219 0.4955 0.799 −3.8 0.000144 0.781 0.25919 0.212034 0.296591 14 120 215 37 187 216 rs2456811 Imputed T DOM 789 0.6017 0.1465 0.4515 0.8019 −3.466 0.000527 0.781 0.25919 0.212034 0.296591 14 120 215 37 187 216 rs2476976 Imputed C DOM 799 1.596 0.1449 1.201 2.12 3.225 0.001258 0.7326 0.29287 0.323529 0.2681 29 173 155 37 163 242 rs2484911 Imputed A DOM 797 1.56 0.1448 1.175 2.073 3.071 0.002132 0.5269 0.26725 0.296348 0.243764 23 165 168 30 155 256 rs2488557 Imputed C DOM 787 0.5503 0.1765 0.3894 0.7777 −3.384 0.000713 0.5179 0.12643 0.096264 0.150342 4 59 285 6 120 313 rs250162 Imputed C ADD 777 0.7333 0.1252 0.5738 0.9373 −2.477 0.01324 0.8414 0.23423 0.205279 0.256881 15 110 216 26 172 238 rs250162 Imputed C DOM 777 0.6818 0.1495 0.5086 0.9139 −2.562 0.0104 0.8414 0.23423 0.205279 0.256881 15 110 216 26 172 238 rs2560708 Imputed T ADD 770 0.6815 0.1471 0.5108 0.9092 −2.607 0.009133 0.07361 0.17078 0.14058 0.195294 3 91 251 12 142 271 rs2617841 Imputed G DOM 737 0.679 0.1512 0.5048 0.9132 −2.56 0.01045 0.6955 0.2517 0.218373 0.279012 15 115 202 29 168 208 rs2622499 Imputed G DOM 798 0.6691 0.149 0.4996 0.8961 −2.696 0.007022 0.0308 0.20677 0.180282 0.227991 10 108 237 14 174 255 rs264129 Imputed T DOM 798 0.653 0.1461 0.4904 0.8695 −2.917 0.003536 0.8136 0.34211 0.314607 0.364253 44 136 176 51 220 171 rs2642936 Imputed T ADD 767 1.403 0.1248 1.098 1.791 2.712 0.006694 0.8364 0.22555 0.259475 0.198113 22 134 187 18 132 274 rs2660633 Imputed A DOM 800 0.6151 0.1445 0.4634 0.8164 −3.364 0.000769 0.5437 0.285 0.239496 0.32167 19 133 205 42 201 200 rs2660634 Imputed C DOM 800 0.6151 0.1445 0.4634 0.8164 −3.364 0.000769 0.5437 0.285 0.239496 0.32167 19 133 205 42 201 200 rs2660648 Imputed A ADD 790 0.6269 0.1219 0.4937 0.7961 −3.831 0.000128 0.781 0.25886 0.211429 0.296591 14 120 216 37 187 216 rs2660648 Imputed A DOM 790 0.5989 0.1465 0.4494 0.798 −3.501 0.000464 0.781 0.25886 0.211429 0.296591 14 120 216 37 187 216 rs2681505 Imputed T ADD 800 0.6338 0.1259 0.4952 0.8112 −3.621 0.000293 0.2824 0.2375 0.194678 0.272009 7 125 225 32 177 234 rs277411 Imputed G DOM 797 0.346 0.3255 0.1828 0.6549 −3.261 0.001112 1 0.03639 0.018207 0.051136 0 13 344 1 43 396 rs2832634 Imputed G ADD 767 1.706 0.2347 1.077 2.702 2.276 0.02282 1 0.05541 0.069971 0.043632 1 46 296 1 35 388 rs2832637 Imputed T ADD 767 1.706 0.2347 1.077 2.702 2.276 0.02282 1 0.05541 0.069971 0.043632 1 46 296 1 35 388 rs2843167 Imputed A DOM 789 0.5976 0.1456 0.4493 0.795 −3.536 0.000406 0.6009 0.2858 0.241477 0.32151 21 128 203 40 201 196 rs2876227 Imputed C ADD 780 1.336 0.1077 1.082 1.65 2.692 0.007104 0.5865 0.35897 0.396848 0.328306 61 155 133 43 197 191 rs2876227 Imputed C GEN 780 9.11 0.01051 0.5865 0.35897 0.396848 0.328306 61 155 133 43 197 191 rs2882097 Imputed A DOM 800 1.654 0.1456 1.243 2.2 3.456 0.000547 0.9326 0.29688 0.329132 0.27088 31 173 153 40 160 243 rs2909862 Imputed G DOM 680 1.87 0.1696 1.341 2.608 3.692 0.000223 0.5231 0.40147 0.447712 0.363636 53 168 85 52 168 154 rs3001945 Imputed T DOM 792 1.587 0.1626 1.154 2.182 2.84 0.004513 0.4666 0.14141 0.169014 0.118993 8 104 243 5 94 338 rs3011020 Imputed C DOM 791 1.591 0.1626 1.157 2.188 2.856 0.004284 0.4664 0.14159 0.169492 0.118993 8 104 242 5 94 338 rs36071725 Geno- C ADD 800 1.524 0.1104 1.228 1.892 3.818 0.000134 0.4813 0.34438 0.396359 0.302483 60 163 134 30 208 205 typed rs36071725 Geno- C GEN 800 18.94 7.72E−05 0.4813 0.34438 0.396359 0.302483 60 163 134 30 208 205 typed rs373983 Imputed G DOM 782 1.553 0.154 1.148 2.1 2.858 0.004263 0.3368 0.41113 0.451149 0.379032 70 174 104 69 191 174 rs3743794 Imputed G DOM 797 0.587 0.1492 0.4382 0.7864 −3.571 0.000356 0.8817 0.39084 0.34887 0.424379 49 149 156 74 228 141 rs3756154 Imputed C ADD 800 0.7138 0.1326 0.5504 0.9257 −2.542 0.01103 0.03097 0.20625 0.179272 0.227991 10 108 239 14 174 255 rs3756154 Imputed C DOM 800 0.6634 0.1489 0.4955 0.8883 −2.756 0.005859 0.03097 0.20625 0.179272 0.227991 10 108 239 14 174 255 rs3775850 Imputed A DOM 797 0.6253 0.1569 0.4598 0.8505 −2.992 0.002768 0.212 0.17127 0.140845 0.195701 6 88 261 12 149 281 rs3775851 Imputed C DOM 798 0.6341 0.1569 0.4662 0.8624 −2.903 0.003694 0.2128 0.17043 0.140845 0.194131 6 88 261 12 148 283 rs3793044 Imputed C ADD 800 1.998 0.2096 1.325 3.013 3.302 0.00096 0.2635 0.06938 0.092437 0.05079 4 58 295 2 41 400 rs3793044 Imputed C DOM 800 2.076 0.2229 1.341 3.213 3.276 0.001053 0.2635 0.06938 0.092437 0.05079 4 58 295 2 41 400 rs3793053 Imputed C DOM 784 1.878 0.1992 1.271 2.775 3.163 0.001559 0.8339 0.09311 0.116715 0.074371 4 73 270 3 59 375 rs3796246 Imputed G DOM 797 0.5889 0.193 0.4034 0.8595 −2.744 0.006063 0.6868 0.09598 0.074648 0.113122 3 47 305 5 90 347 rs3806003 Imputed A ADD 800 1.998 0.2096 1.325 3.013 3.302 0.00096 0.2635 0.06938 0.092437 0.05079 4 58 295 2 41 400 rs3806003 Imputed A DOM 800 2.076 0.2229 1.341 3.213 3.276 0.001053 0.2635 0.06938 0.092437 0.05079 4 58 295 2 41 400 rs3806004 Imputed T DOM 799 1.856 0.1976 1.26 2.734 3.131 0.001743 0.8332 0.09199 0.115169 0.073363 4 74 278 3 59 381 rs3806010 Imputed T DOM 799 1.856 0.1976 1.26 2.734 3.131 0.001743 0.8332 0.09199 0.115169 0.073363 4 74 278 3 59 381 rs3806014 Imputed T DOM 796 1.865 0.1984 1.264 2.752 3.143 0.001675 0.8338 0.09234 0.115493 0.073696 4 74 277 3 59 379 rs3806015 Imputed A DOM 799 1.856 0.1976 1.26 2.734 3.131 0.001743 0.8332 0.09199 0.115169 0.073363 4 74 278 3 59 381 rs3806018 Imputed A DOM 790 1.834 0.1988 1.242 2.708 3.051 0.002279 0.8349 0.09304 0.115819 0.074541 4 74 276 3 59 374 rs3806019 Imputed A DOM 799 1.856 0.1976 1.26 2.734 3.131 0.001743 0.8332 0.09199 0.115169 0.073363 4 74 278 3 59 381 rs3806024 Imputed T DOM 784 1.878 0.1992 1.271 2.775 3.163 0.001559 0.8339 0.09311 0.116715 0.074371 4 73 270 3 59 375 rs3915080 Imputed A GEN 785 10.95 0.004188 0.647 0.37134 0.409348 0.340278 63 163 127 42 210 180 rs3942254 Imputed T ADD 789 0.7293 0.107 0.5913 0.8995 −2.95 0.003182 0.9408 0.39607 0.358571 0.425968 49 153 148 74 226 139 rs3942254 Imputed T DOM 789 0.6079 0.1519 0.4513 0.8187 −3.277 0.00105 0.9408 0.39607 0.358571 0.425968 49 153 148 74 226 139 rs3945085 Imputed A DOM 797 1.637 0.1456 1.231 2.178 3.387 0.000706 0.8656 0.29674 0.328652 0.270975 31 172 153 40 159 242 rs3976737 Imputed G ADD 753 0.5945 0.1454 0.4471 0.7905 −3.577 0.000348 0.3603 0.16799 0.126866 0.200957 7 71 257 18 132 267 rs399485 Imputed A DOM 794 1.449 0.145 1.09 1.925 2.556 0.01057 0.7862 0.26763 0.299157 0.242009 29 155 172 26 160 252 rs4029119 Imputed G ADD 800 0.2198 0.3906 0.1022 0.4726 −3.878 0.000105 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs4029119 Imputed G DOM 800 0.2258 0.4052 0.102 0.4995 −3.673 0.00024 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs4076201 Imputed G GEN 776 8.852 0.01196 0.913 0.20747 0.232558 0.1875 23 114 207 11 140 281 rs4076201 Imputed G REC 776 2.978 0.3815 1.41 6.29 2.86 0.004234 0.913 0.20747 0.232558 0.1875 23 114 207 11 140 281 rs41395945 Imputed G ADD 767 1.706 0.2347 1.077 2.702 2.276 0.02282 1 0.5541 0.069971 0.043632 1 46 296 1 35 388 rs41395945 Imputed G DOM 767 1.77 0.2427 1.1 2.849 2.353 0.0186 1 0.05541 0.069971 0.043632 1 46 296 1 35 388 rs4146972 Geno- T DOM 800 1.441 0.1516 1.071 1.94 2.41 0.01594 0.8159 0.18688 0.207283 0.170429 11 126 220 18 115 310 typed rs4238087 Imputed G DOM 789 0.719 0.1681 0.5172 0.9995 −1.963 0.04968 0.6536 0.13688 0.117564 0.152523 4 75 274 12 109 315 rs4251569 Imputed T ADD 791 0.7164 0.1513 0.5325 0.9637 −2.204 0.02753 0.6528 0.13654 0.117232 0.152174 4 75 275 12 109 316 rs4251569 Imputed T DOM 791 0.7189 0.1681 0.5171 0.9993 −1.964 0.04952 0.6528 0.13654 0.117232 0.152174 4 75 275 12 109 316 rs4273613 Imputed T ADD 800 0.2198 0.3906 0.1022 0.4726 −3.878 0.000105 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs4273613 Imputed T DOM 800 0.2258 0.4052 0.102 0.4995 −3.673 0.00024 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs4291049 Imputed T REC 798 0.5495 0.1747 0.3902 0.7739 −3.428 0.000609 0.8875 0.49185 0.44507 0.529345 65 186 104 129 211 103 rs4315598 Imputed T ADD 799 1.348 0.1061 1.095 1.66 2.813 0.004904 0.3986 0.35982 0.39916 0.328054 64 157 136 45 200 197 rs4315598 Imputed T GEN 799 9.777 0.007533 0.3986 0.35982 0.39916 0.328054 64 157 136 45 200 197 rs4315598 Imputed T REC 799 1.885 0.2107 1.247 2.849 3.009 0.002624 0.3986 0.35982 0.39916 0.328054 64 157 136 45 200 197 rs4321395 Imputed A DOM 760 0.6185 0.1611 0.451 0.8482 −2.982 0.002863 0.8837 0.45526 0.420588 0.483333 65 156 119 91 224 105 rs4321596 Geno- T REC 800 2.132 0.296 1.194 3.809 2.559 0.0105 0.0184 0.23625 0.247899 0.226862 35 107 215 22 157 264 typed rs4324417 Imputed T DOM 800 1.724 0.1627 1.254 2.372 3.349 0.000812 0.6702 0.46375 0.504202 0.431151 85 190 82 90 202 151 rs4328619 Geno- G DOM 800 0.6851 0.1653 0.4955 0.9472 −2.288 0.02212 0.357 0.47688 0.448179 0.5 71 178 108 104 235 104 typed rs4338909 Imputed T ADD 798 1.366 0.1028 1.116 1.67 3.031 0.002435 0.4636 0.40664 0.448179 0.373016 70 180 107 67 195 179 rs4370878 Imputed G DOM 798 1.625 0.1458 1.221 2.162 3.327 0.000877 0.9327 0.29762 0.328652 0.272624 31 172 153 40 161 241 rs4379434 Geno- T DOM 800 1.624 0.1546 1.199 2.199 3.136 0.001712 0.7172 0.42063 0.446779 0.399549 63 193 101 81 192 170 typed rs4416407 Imputed T DOM 791 1.831 0.1801 1.287 2.606 3.359 0.000782 0.8311 0.52212 0.553824 0.496575 97 197 59 117 201 120 rs4417899 Imputed C REC 793 0.544 0.18 0.3823 0.7742 −3.382 0.000721 0.9432 0.47415 0.442254 0.5 59 196 100 120 198 120 rs4442732 Imputed A ADD 658 0.6071 0.133 0.4678 0.7879 −3.752 0.000176 0.1382 0.33739 0.284483 0.379076 21 123 146 45 189 134 rs4444612 Imputed G ADD 795 1.36 0.1064 1.104 1.675 2.888 0.003879 0.3988 0.36101 0.401408 0.328409 64 157 134 45 199 196 rs4444612 Imputed G GEN 795 10.03 0.006632 0.3988 0.36101 0.401408 0.328409 64 157 134 45 199 196 rs4444612 Imputed G REC 795 1.891 0.2107 1.251 2.858 3.023 0.002503 0.3988 0.36101 0.401408 0.328409 64 157 134 45 199 196 rs4450660 Imputed C DOM 791 1.503 0.1459 1.129 2 2.791 0.005256 0.0061 0.23831 0.267606 0.21445 16 158 181 15 157 264 rs4509702 Imputed C DOM 798 1.625 0.1458 1.221 2.162 3.327 0.000877 0.9327 0.29762 0.328652 0.272624 31 172 153 40 161 241 rs4526920 Imputed G GEN 795 12.3 0.002134 0.2253 0.28616 0.331461 0.249431 42 152 162 30 159 250 rs4533145 Imputed T DOM 788 0.4949 0.1927 0.3392 0.7219 −3.652 0.000261 0.7024 0.10279 0.072443 0.127294 3 45 304 6 99 331 rs4557006 Imputed A DOM 753 0.6286 0.1619 0.4577 0.8634 −2.867 0.00414 0.8835 0.45684 0.422849 0.484375 65 155 117 91 221 104 rs4570530 Imputed C DOM 798 1.625 0.1458 1.221 2.162 3.327 0.000877 0.9327 0.29762 0.328652 0.272624 31 172 153 40 161 241 rs4615971 Imputed C DOM 798 1.614 0.1449 1.215 2.144 3.304 0.000953 0.8644 0.29261 0.32493 0.26644 30 172 155 37 161 243 rs4628119 Imputed A DOM 800 0.6745 0.1474 0.5052 0.9004 −2.672 0.007537 0.4259 0.23125 0.20028 0.256208 17 109 231 30 167 246 rs4664443 Imputed G ADD 799 0.7174 0.1085 0.5799 0.8874 −3.06 0.002211 0.7083 0.38235 0.341292 0.41535 41 161 154 73 222 148 rs4688259 Imputed T DOM 792 1.832 0.1801 1.287 2.608 3.363 0.000772 0.9433 0.52525 0.556497 0.5 99 196 59 120 198 120 rs4688632 Imputed G REC 797 0.5583 0.1725 0.3981 0.783 −3.378 0.000731 1 0.49812 0.463483 0.526077 67 196 93 131 202 108 rs4695284 Imputed A ADD 469 2.105 0.2029 1.414 3.133 3.667 0.000245 0.4244 0.1322 0.176744 0.094488 7 62 146 3 42 209 rs4700302 Imputed A ADD 725 0.5167 0.1985 0.3501 0.7624 −3.327 0.000879 0.1879 0.0931 0.066066 0.116071 0 44 289 3 85 304 rs4702720 Imputed A ADD 628 0.6094 0.1416 0.4617 0.8044 −3.497 0.00047 0.1125 0.2285 0.183099 0.265988 14 76 194 26 131 187 rs4702720 Imputed A DOM 628 0.5402 0.171 0.3863 0.7553 −3.601 0.000317 0.1125 0.2285 0.183099 0.265988 14 76 194 26 131 187 rs4711091 Geno- G GEN 800 13.3 0.001292 0.3943 0.47 0.519608 0.430023 102 167 88 81 219 143 typed rs4714484 Imputed A ADD 799 0.6694 0.1425 0.5063 0.8852 −2.816 0.004864 0.7969 0.16333 0.133053 0.187783 6 83 268 14 138 290 rs4736802 Imputed G DOM 794 1.64 0.1547 1.211 2.221 3.196 0.001395 0.7154 0.41877 0.445225 0.39726 62 193 101 80 188 170 rs4760785 Imputed A ADD 771 0.7218 0.1078 0.5844 0.8916 −3.025 0.002485 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs4760785 Imputed A DOM 771 0.6464 0.1598 0.4726 0.8841 −2.731 0.006318 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs4760785 Imputed A GEN 771 9.268 0.009717 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs4760894 Imputed T ADD 771 0.7218 0.1078 0.5844 0.8916 −3.025 0.002485 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs4760894 Imputed T DOM 771 0.6464 0.1598 0.4726 0.8841 −2.731 0.006318 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs4760894 Imputed T GEN 771 9.268 0.009717 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs4760895 Imputed A ADD 771 0.7218 0.1078 0.5844 0.8916 −3.025 0.002485 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs4760895 Imputed A DOM 771 0.6464 0.1598 0.4726 0.8841 −2.731 0.006318 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs4760895 Imputed A GEN 771 9.268 0.009717 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs4764738 Imputed A ADD 785 1.331 0.1042 1.085 1.633 2.742 0.0061 0.8865 0.49236 0.527143 0.464368 97 175 78 92 220 123 rs4764738 Imputed A GEN 785 7.557 0.02286 0.8865 0.49236 0.527143 0.464368 97 175 78 92 220 123 rs4764974 Imputed T ADD 796 1.322 0.1036 1.079 1.62 2.695 0.007028 0.8315 0.48995 0.523876 0.4625 97 179 80 92 223 125 rs4764974 Imputed T GEN 796 7.298 0.02602 0.8315 0.48995 0.523876 0.4625 97 179 80 92 223 125 rs4798366 Imputed G REC 780 1.597 0.2447 0.9889 2.58 1.915 0.05555 0.1069 0.33269 0.338109 0.328306 42 152 155 34 215 182 rs483159 Imputed T DOM 718 1.425 0.1565 1.048 1.936 2.262 0.0237 0.6567 0.21379 0.236196 0.195153 16 122 188 19 115 258 rs4836502 Imputed T DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.8149 0.34563 0.317927 0.367946 44 139 174 53 220 170 rs4836507 Imputed C DOM 791 0.6716 0.1473 0.5032 0.8964 −2.703 0.006874 0.6933 0.34324 0.316901 0.364679 44 137 174 52 214 170 rs4836744 Imputed A ADD 797 0.7163 0.1117 0.5755 0.8916 −2.988 0.002809 0.6748 0.30176 0.262712 0.332957 24 138 192 51 193 199 rs4836744 Imputed A DOM 797 0.6971 0.144 0.5257 0.9245 −2.505 0.01224 0.6748 0.30176 0.262712 0.332957 24 138 192 51 193 199 rs4848944 Geno- C REC 800 0.6741 0.1744 0.4789 0.9488 −2.261 0.02373 0.6208 0.48438 0.47619 0.490971 69 202 86 115 205 123 typed rs4851529 Imputed A DOM 798 0.6968 0.1498 0.5195 0.9346 −2.411 0.0159 0.883 0.40288 0.375 0.425339 54 159 143 74 228 140 rs4851531 Imputed T DOM 785 0.7275 0.1515 0.5406 0.9789 −2.101 0.03565 0.8825 0.40764 0.382184 0.427918 54 158 136 75 224 138 rs4858046 Geno- T GEN 800 9.709 0.007792 0.544 0.37 0.406162 0.340858 62 166 129 43 216 184 typed rs4878214 Imputed A ADD 628 0.5979 0.1405 0.454 0.7875 −3.661 0.000252 0.5024 0.23248 0.181159 0.272727 8 84 184 29 134 189 rs4880803 Imputed A ADD 789 0.7753 0.1121 0.6223 0.9658 −2.27 0.02319 0.9344 0.31559 0.288352 0.337529 32 139 181 47 201 189 rs489441 Imputed G ADD 748 1.446 0.1212 1.14 1.834 3.044 0.002335 0.4584 0.26939 0.307808 0.238554 27 151 155 23 152 240 rs489441 Imputed G DOM 748 1.584 0.1496 1.181 2.123 3.074 0.002112 0.4584 0.26939 0.307808 0.238554 27 151 155 23 152 240 rs4896568 Imputed T DOM 774 0.6713 0.1492 0.5011 0.8993 −2.672 0.007546 0.4888 0.23902 0.208455 0.263341 18 107 218 30 167 234 rs4938851 Imputed T DOM 800 1.543 0.1498 1.151 2.07 2.898 0.00376 0.4999 0.19563 0.222689 0.173815 12 135 210 15 124 304 rs4964416 Imputed C DOM 799 0.598 0.1645 0.4332 0.8256 −3.125 0.001776 0.1781 0.48123 0.442577 0.512443 71 174 112 104 245 93 rs5756669 Imputed C DOM 800 1.724 0.1627 1.254 2.372 3.349 0.000812 0.6702 0.46375 0.504202 0.431151 85 190 82 90 202 151 rs6033138 Imputed C ADD 796 1.371 0.105 1.116 1.685 3.008 0.002629 0.3261 0.37437 0.415493 0.34127 68 159 128 50 201 190 rs6033138 Imputed C GEN 796 10.23 0.005998 0.3261 0.37437 0.415493 0.34127 68 159 128 50 201 190 rs6033138 Imputed C REC 796 1.836 0.2034 1.232 2.736 2.987 0.002813 0.3261 0.37437 0.415493 0.34127 68 159 128 50 201 190 rs6040619 Imputed C ADD 800 1.337 0.1054 1.088 1.644 2.757 0.005839 0.4439 0.36188 0.40056 0.3307 64 158 135 46 201 196 rs6040619 Imputed C GEN 800 9.282 0.009648 0.4439 0.36188 0.40056 0.3307 64 158 135 46 201 196 rs6040619 Imputed C REC 800 1.844 0.2095 1.223 2.78 2.92 0.003504 0.4439 0.36188 0.40056 0.3307 64 158 135 46 201 196 rs6040625 Imputed T ADD 800 1.343 0.1053 1.093 1.651 2.802 0.005079 0.3996 0.36125 0.40056 0.329571 64 158 135 46 200 197 rs6040625 Imputed T GEN 800 9.403 0.009081 0.3996 0.36125 0.40056 0.329571 64 158 135 46 200 197 rs6040625 Imputed T REC 800 1.844 0.2095 1.223 2.78 2.92 0.003504 0.3996 0.36125 0.40056 0.329571 64 158 135 46 200 197 rs6040630 Imputed A ADD 800 1.353 0.1061 1.099 1.666 2.854 0.004317 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040630 Imputed A GEN 800 9.956 0.006888 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040630 Imputed A REC 800 1.892 0.2107 1.252 2.859 3.026 0.002474 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040633 Imputed A ADD 799 1.35 0.1061 1.096 1.662 2.826 0.004712 0.3986 0.35982 0.39916 0.328054 64 157 136 45 200 197 rs6040633 Imputed A GEN 799 9.841 0.007297 0.3986 0.35982 0.39916 0.328054 64 157 136 45 200 197 rs6040633 Imputed A REC 799 1.888 0.2106 1.249 2.853 3.016 0.002559 0.3986 0.35982 0.39916 0.328054 64 157 136 45 200 197 rs6040634 Imputed T ADD 800 1.353 0.1061 1.099 1.666 2.854 0.004317 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040634 Imputed T GEN 800 9.956 0.006888 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040634 Imputed T REC 800 1.892 0.2107 1.252 2.859 3.026 0.002474 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040636 Imputed T ADD 799 1.359 0.1061 1.103 1.673 2.888 0.00388 0.3574 0.3592 0.39916 0.326923 64 157 136 45 199 198 rs6040636 Imputed T GEN 799 10.05 0.006571 0.3574 0.3592 0.39916 0.326923 64 157 136 45 199 198 rs6040636 Imputed T REC 799 1.892 0.2107 1.252 2.859 3.027 0.002467 0.3574 0.3592 0.39916 0.326923 64 157 136 45 199 198 rs6040638 Imputed C ADD 800 1.353 0.1061 1.099 1.666 2.854 0.004317 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040638 Imputed C GEN 800 9.956 0.006888 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040638 Imputed C REC 800 1.892 0.2107 1.252 2.859 3.026 0.002474 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040644 Imputed A ADD 800 1.353 0.1061 1.099 1.666 2.854 0.004317 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040644 Imputed A GEN 800 9.956 0.006888 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040644 Imputed A REC 800 1.892 0.2107 1.252 2.859 3.026 0.002474 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6040667 Imputed T ADD 787 1.352 0.1076 1.095 1.67 2.804 0.005046 0.5346 0.35642 0.396011 0.324541 61 156 134 43 197 196 rs6040667 Imputed T GEN 787 9.469 0.008785 0.5346 0.35642 0.396011 0.324541 61 156 134 43 197 196 rs6040667 Imputed T REC 787 1.878 0.2152 1.232 2.864 2.93 0.003389 0.5346 0.35642 0.396011 0.324541 61 156 134 43 197 196 rs6040668 Imputed C ADD 787 1.352 0.1076 1.095 1.67 2.804 0.005046 0.5346 0.35642 0.396011 0.324541 61 156 134 43 197 196 rs6040668 Imputed C GEN 787 9.469 0.008785 0.5346 0.35642 0.396011 0.324541 61 156 134 43 197 196 rs6040668 Imputed C REC 787 1.878 0.2152 1.232 2.864 2.93 0.003389 0.5346 0.35642 0.396011 0.324541 61 156 134 43 197 196 rs6043066 Geno- G DOM 800 1.67 0.1467 1.253 2.227 3.497 0.000471 0.7679 0.235 0.268908 0.207675 19 154 184 23 138 282 typed rs6048146 Imputed G DOM 800 2.46 0.3199 1.314 4.605 2.814 0.004893 0.00359 0.0375 0.04902 0.028217 1 33 323 4 17 422 rs6082725 Geno- T DOM 800 2.46 0.3199 1.314 4.605 2.814 0.004893 0.00359 0.0375 0.04902 0.028217 1 33 323 4 17 422 typed rs6131206 Imputed C ADD 778 1.252 0.1109 1.007 1.556 2.026 0.04277 0.4542 0.31362 0.343109 0.290618 45 144 152 36 182 219 rs6131208 Imputed T ADD 788 1.358 0.1075 1.1 1.676 2.846 0.004434 0.5343 0.35596 0.396011 0.323799 61 156 134 43 197 197 rs6131208 Imputed T GEN 788 9.654 0.00801 0.5343 0.35596 0.396011 0.323799 61 156 134 43 197 197 rs6131208 Imputed T REC 788 1.885 0.2151 1.237 2.874 2.948 0.0032 0.5343 0.35596 0.396011 0.323799 61 156 134 43 197 197 rs6134243 Imputed C ADD 800 1.353 0.1061 1.099 1.666 2.854 0.004317 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6134243 Imputed C GEN 800 9.956 0.006888 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6134243 Imputed C REC 800 1.892 0.2107 1.252 2.859 3.026 0.002474 0.3983 0.35938 0.39916 0.327314 64 157 136 45 200 198 rs6136020 Imputed A DOM 799 0.5431 0.1594 0.3974 0.7422 −3.831 0.000128 0.5335 0.17146 0.135854 0.200226 11 75 271 15 147 280 rs613799 Imputed C DOM 686 1.64 0.1564 1.207 2.228 3.161 0.00157 0.7076 0.28426 0.317434 0.257853 23 147 134 30 137 215 rs644041 Imputed G ADD 736 1.415 0.1215 1.116 1.796 2.86 0.004237 0.5161 0.2731 0.309451 0.243873 27 149 152 24 151 233 rs644041 Imputed G DOM 736 1.556 0.1508 1.158 2.092 2.932 0.003363 0.5161 0.2731 0.309451 0.243873 27 149 152 24 151 233 rs647645 Imputed C ADD 796 0.6924 0.1019 0.567 0.8454 −3.608 0.000308 0.08529 0.44284 0.391854 0.484091 58 163 135 110 206 124 rs647645 Imputed C GEN 796 13.04 0.001476 0.08529 0.44284 0.391854 0.484091 58 163 135 110 206 124 rs647645 Imputed C REC 796 0.5812 0.182 0.4068 0.8303 −2.982 0.002867 0.08529 0.44284 0.391854 0.484091 58 163 135 110 206 124 rs6495554 Imputed C GEN 800 9.326 0.009436 0.9088 0.19063 0.215686 0.170429 20 114 223 8 135 300 rs6495554 Imputed C REC 800 3.433 0.4298 1.478 7.972 2.87 0.004111 0.9088 0.19063 0.215686 0.170429 20 114 223 8 135 300 rs6495555 Imputed C GEN 800 9.326 0.009436 0.9088 0.19063 0.215686 0.170429 20 114 223 8 135 300 rs6495555 Imputed C REC 800 3.433 0.4298 1.478 7.972 2.87 0.004111 0.9088 0.19063 0.215686 0.170429 20 114 223 8 135 300 rs6544728 Imputed T DOM 794 1.526 0.1458 1.147 2.032 2.901 0.003725 0.01412 0.23678 0.266949 0.2125 16 157 181 16 155 269 rs6550705 Imputed C ADD 800 1.366 0.1079 1.105 1.688 2.889 0.00386 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs6550705 Imputed C GEN 800 9.972 0.006832 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs6550707 Imputed T GEN 797 9.958 0.00688 0.821 0.37641 0.412676 0.347285 65 163 127 46 215 181 rs658108 Imputed A DOM 798 1.56 0.1448 1.174 2.071 3.069 0.002149 0.471 0.26817 0.296919 0.244898 23 166 168 30 156 255 rs6593441 Imputed A DOM 785 1.577 0.1691 1.132 2.196 2.693 0.007076 0.7536 0.12994 0.152422 0.111751 7 93 251 7 83 344 rs668732 Imputed A DOM 787 1.778 0.1671 1.281 2.467 3.444 0.000574 0.2538 0.48729 0.545455 0.44023 106 172 74 89 205 141 rs671041 Imputed A DOM 798 1.56 0.1448 1.174 2.071 3.069 0.002149 0.471 0.26817 0.296919 0.244898 23 166 168 30 156 255 rs6719700 Imputed A ADD 695 1.427 0.1498 1.064 1.914 2.374 0.01759 0.5793 0.16403 0.190323 0.142857 8 102 200 8 94 283 rs6719700 Imputed A DOM 695 1.536 0.1676 1.106 2.133 2.559 0.01049 0.5793 0.16403 0.190323 0.142857 8 102 200 8 94 283 rs6722640 Imputed T DOM 797 0.682 0.1502 0.5081 0.9154 −2.548 0.01082 0.8836 0.40715 0.377465 0.430995 56 156 143 77 227 138 rs6743092 Imputed T ADD 789 1.36 0.1049 1.108 1.671 2.935 0.003334 0.4767 0.4924 0.533803 0.458525 99 181 75 87 224 123 rs6743092 Imputed T GEN 789 8.823 0.01214 0.4767 0.4924 0.533803 0.458525 99 181 75 87 224 123 rs6743092 Imputed T REC 789 1.57 0.1704 1.124 2.192 2.646 0.008151 0.4767 0.4924 0.533803 0.458525 99 181 75 87 224 123 rs6744759 Imputed G REC 794 1.692 0.2617 1.013 2.827 2.01 0.04442 0.5987 0.28149 0.291785 0.273243 37 132 184 29 183 229 rs6746170 Imputed A DOM 797 1.528 0.1455 1.149 2.032 2.914 0.003568 0.0061 0.23839 0.269014 0.213801 16 159 180 15 159 268 rs6759922 Imputed A DOM 760 0.6185 0.1611 0.451 0.8482 −2.982 0.002863 0.8837 0.45526 0.420588 0.483333 65 156 119 91 224 105 rs6769864 Imputed T GEN 800 9.838 0.007307 0.5931 0.36375 0.403361 0.331828 60 168 129 42 210 191 rs6773932 Imputed C GEN 782 10.92 0.004251 0.5414 0.37404 0.411932 0.343023 63 164 125 42 211 177 rs6774353 Imputed A GEN 800 9.838 0.007307 0.5931 0.36375 0.403361 0.331828 60 168 129 42 210 191 rs6781670 Imputed C GEN 800 9.296 0.009578 0.7594 0.36125 0.397759 0.331828 60 164 133 42 210 191 rs6786431 Imputed A GEN 782 10.92 0.004251 0.5414 0.37404 0.411932 0.343023 63 164 125 42 211 177 rs6789091 Imputed T GEN 782 10.92 0.004251 0.5414 0.37404 0.411932 0.343023 63 164 125 42 211 177 rs6791296 Imputed T ADD 757 0.6225 0.164 0.4514 0.8586 −2.889 0.00386 0.6116 0.12285 0.095588 0.145084 2 61 277 11 99 307 rs6792662 Imputed G DOM 792 1.844 0.1801 1.296 2.624 3.398 0.000678 0.8868 0.52588 0.557746 0.5 100 196 59 120 197 120 rs6797574 Imputed G GEN 782 10.92 0.004251 0.5414 0.37404 0.411932 0.343023 63 164 125 42 211 177 rs6797882 Imputed G GEN 776 11.03 0.004027 0.4454 0.37693 0.415473 0.345433 63 164 122 42 211 174 rs6805139 Imputed G DOM 797 1.812 0.1727 1.292 2.542 3.442 0.000577 0.7769 0.50439 0.539216 0.476136 95 195 67 110 199 131 rs6806043 Imputed C ADD 800 1.366 0.1079 1.105 1.688 2.889 0.00386 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs6806043 Imputed C GEN 800 9.972 0.006832 0.6465 0.36313 0.403361 0.3307 60 168 129 42 209 192 rs6850716 Imputed C GEN 799 12.52 0.001916 0.7677 0.23467 0.270308 0.205882 29 135 193 13 156 273 rs6867153 Imputed A REC 795 0.528 0.177 0.3733 0.7469 −3.609 0.000307 1 0.48805 0.44051 0.526018 62 187 104 127 211 104 rs687047 Imputed C ADD 800 0.6526 0.1561 0.4806 0.8861 −2.734 0.006248 0.2074 0.12813 0.102241 0.148984 2 69 286 15 102 326 rs6871041 Imputed G DOM 666 0.6 0.1598 0.4387 0.8207 −3.196 0.001391 0.6287 0.27628 0.239057 0.306233 20 102 175 28 170 171 rs688358 Imputed A ADD 795 0.6534 0.156 0.4812 0.8872 −2.727 0.006386 0.2666 0.12893 0.103107 0.14966 2 69 283 15 102 324 rs6888012 Imputed A REC 795 0.528 0.177 0.3733 0.7469 −3.609 0.000307 1 0.48805 0.44051 0.526018 62 187 104 127 211 104 rs6908481 Imputed C REC 784 1.96 0.1947 1.338 2.871 3.458 0.000545 0.2049 0.39796 0.438395 0.365517 77 152 120 56 206 173 rs7032231 Imputed A ADD 789 1.212 0.1105 0.9756 1.504 1.737 0.08246 0.3821 0.33714 0.357955 0.320366 40 172 140 44 192 201 rs7067638 Imputed T DOM 795 1.6 0.1731 1.14 2.247 2.717 0.00659 0.4039 0.12075 0.142655 0.103175 7 87 260 7 77 357 rs7077799 Imputed A DOM 745 1.625 0.1513 1.208 2.185 3.208 0.001335 0.9311 0.3047 0.33689 0.279376 30 161 137 38 157 222 rs7082163 Imputed A ADD 800 1.58 0.1552 1.166 2.142 2.948 0.003195 0.4017 0.12 0.145658 0.099323 8 88 261 6 76 361 rs7082163 Imputed A DOM 800 1.684 0.1729 1.2 2.364 3.014 0.002574 0.4017 0.12 0.145658 0.099323 8 88 261 6 76 361 rs7089661 Imputed C DOM 800 1.62 0.1448 1.22 2.152 3.335 0.000854 0.9322 0.29313 0.32493 0.267494 30 172 155 38 161 244 rs7101319 Imputed C ADD 797 1.567 0.1554 1.156 2.125 2.891 0.003836 0.3994 0.11982 0.14507 0.099548 8 87 260 6 76 360 rs7101319 Imputed C DOM 797 1.667 0.1733 1.187 2.341 2.95 0.003178 0.3994 0.11982 0.14507 0.099548 8 87 260 6 76 360 rs710832 Geno- A GEN 800 10.04 0.006605 0.2223 0.25125 0.232493 0.266366 14 138 205 43 150 250 typed rs710832 Geno- A REC 800 0.3805 0.3178 0.2041 0.7092 −3.041 0.002357 0.2223 0.25125 0.232493 0.266366 14 138 205 43 150 250 typed rs7134262 Imputed T GEN 796 18.44 9.88E−05 0.8191 0.36621 0.394958 0.342825 67 148 142 38 225 176 rs7134262 Imputed T REC 796 2.449 0.2188 1.595 3.76 4.092 4.27E−05 0.8191 0.36621 0.394958 0.342825 67 148 142 38 225 176 rs7134671 Imputed T GEN 786 6.843 0.03266 0.7059 0.38168 0.416193 0.353687 63 167 122 54 199 181 rs7138300 Imputed C ADD 771 0.7218 0.1078 0.5844 0.8916 −3.025 0.002485 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs7138300 Imputed C DOM 771 0.6464 0.1598 0.4726 0.8841 −2.731 0.006318 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs7138300 Imputed C GEN 771 9.268 0.009717 0.3076 0.44617 0.405523 0.478923 54 171 119 92 225 110 rs7163931 Imputed G GEN 800 9.326 0.009436 0.9088 0.19063 0.215686 0.170429 20 114 223 8 135 300 rs7163931 Imputed G REC 800 3.433 0.4298 1.478 7.972 2.87 0.004111 0.9088 0.19063 0.215686 0.170429 20 114 223 8 135 300 rs7171486 Geno- G DOM 800 0.7681 0.1448 0.5783 1.02 −1.821 0.06855 0.04585 0.35875 0.343137 0.371332 54 137 166 62 205 176 typed rs7172611 Imputed G GEN 800 9.499 0.008657 0.9089 0.19125 0.217087 0.170429 20 115 222 8 135 300 rs7172611 Imputed G REC 800 3.433 0.4298 1.478 7.972 2.87 0.004111 0.9089 0.19125 0.217087 0.170429 20 115 222 8 135 300 rs7172689 Imputed T GEN 800 9.499 0.008657 0.9089 0.19125 0.217087 0.170429 20 115 222 8 135 300 rs7172689 Imputed T REC 800 3.433 0.4298 1.478 7.972 2.87 0.004111 0.9089 0.19125 0.217087 0.170429 20 115 222 8 135 300 rs7175701 Imputed C GEN 799 8.043 0.01793 1 0.20901 0.231742 0.190745 23 119 214 12 145 286 rs7180245 Imputed A GEN 800 9.499 0.008657 0.9089 0.19125 0.217087 0.170429 20 115 222 8 135 300 rs7180245 Imputed A REC 800 3.433 0.4298 1.478 7.972 2.87 0.004111 0.9089 0.19125 0.217087 0.170429 20 115 222 8 135 300 rs7220603 Geno- A ADD 800 0.7182 0.1147 0.5737 0.8992 −2.886 0.003898 0.9321 0.29375 0.257703 0.322799 22 140 195 46 194 203 typed rs7282518 Imputed T ADD 673 1.688 0.1538 1.249 2.283 3.405 0.000662 0.08317 0.17608 0.213816 0.144986 11 108 185 3 101 265 rs7283476 Imputed T ADD 800 0.3701 0.3146 0.1998 0.6857 −3.159 0.001582 0.3047 0.0375 0.019608 0.051919 1 12 344 1 44 398 rs7283476 Imputed T DOM 800 0.3345 0.3297 0.1753 0.6385 −3.321 0.000898 0.3047 0.0375 0.019608 0.051919 1 12 344 1 44 398 rs7295817 Imputed C GEN 795 10.28 0.005851 0.2702 0.40377 0.359551 0.439636 46 164 146 91 204 144 rs7298255 Imputed A ADD 800 0.7363 0.1048 0.5997 0.9041 −2.922 0.003477 0.4767 0.45875 0.420168 0.489842 63 174 120 100 234 109 rs7298255 Imputed A DOM 800 0.6348 0.1584 0.4654 0.8659 −2.87 0.004111 0.4767 0.45875 0.420168 0.489842 63 174 120 100 234 109 rs7305832 Imputed C GEN 798 18.44 9.88E−05 0.8787 0.36529 0.394958 0.34127 67 148 142 38 225 178 rs7305832 Imputed C REC 798 2.46 0.2188 1.602 3.777 4.113 3.91E−05 0.8787 0.36529 0.394958 0.34127 67 148 142 38 225 178 rs7331467 Imputed A GEN 800 15.12 0.00052 0.2006 0.32813 0.379552 0.286682 52 167 138 42 170 231 rs7392620 Imputed C ADD 783 0.7778 0.1122 0.6242 0.9691 −2.239 0.02513 0.6765 0.31034 0.282857 0.332564 31 136 183 47 194 192 rs742827 Imputed A ADD 727 1.41 0.1113 1.134 1.754 3.087 0.002021 0.692 0.37345 0.419255 0.337037 61 148 113 43 187 175 rs742827 Imputed A GEN 727 10.58 0.005035 0.692 0.37345 0.419255 0.337037 61 148 113 43 187 175 rs742827 Imputed A REC 727 1.914 0.2166 1.252 2.926 2.998 0.002718 0.692 0.37345 0.419255 0.337037 61 148 113 43 187 175 rs7446891 Imputed G DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.8149 0.34563 0.317927 0.367946 44 139 174 53 220 170 rs7448641 Imputed C ADD 800 0.2198 0.3906 0.1022 0.4726 −3.878 0.000105 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs7448641 Imputed C DOM 800 0.2258 0.4052 0.102 0.4995 −3.673 0.00024 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs7484728 Imputed T GEN 788 6.971 0.03064 0.7064 0.38135 0.416193 0.353211 63 167 122 54 200 182 rs7499402 Geno- A ADD 800 1.746 0.1907 1.202 2.538 2.924 0.00346 0.8111 0.08125 0.103641 0.063205 4 66 287 0 56 387 typed rs7529851 Imputed A ADD 800 0.7957 0.1062 0.6462 0.9799 −2.151 0.03144 0.1689 0.4225 0.393557 0.445824 48 185 124 85 225 133 rs7529851 Imputed A GEN 800 5.275 0.07153 0.1689 0.4225 0.393557 0.445824 48 185 124 85 225 133 rs7573951 Imputed G ADD 799 0.7174 0.1085 0.5799 0.8874 −3.06 0.002211 0.7083 0.38235 0.341292 0.41535 41 161 154 73 222 148 rs7599198 Imputed T DOM 717 0.6201 0.1648 0.4489 0.8565 −2.9 0.003737 0.8207 0.447 0.410938 0.476071 60 143 117 85 208 104 rs7600050 Imputed C ADD 763 1.294 0.1099 1.043 1.605 2.343 0.01915 0.6944 0.3578 0.391496 0.330569 49 169 123 46 187 189 rs7607712 Imputed T ADD 784 1.401 0.1287 1.088 1.803 2.618 0.008843 0.3346 0.2111 0.241477 0.186343 17 136 199 13 135 284 rs7607712 Imputed T DOM 784 1.477 0.1494 1.102 1.979 2.609 0.009089 0.3346 0.2111 0.241477 0.186343 17 136 199 13 135 284 rs7613492 Imputed G GEN 792 9.987 0.006783 0.6445 0.36111 0.400568 0.329545 59 164 129 41 208 191 rs7621663 Imputed G ADD 749 1.413 0.113 1.132 1.763 3.057 0.002237 0.6276 0.34312 0.386228 0.308434 53 152 129 32 192 191 rs7621663 Imputed G GEN 749 12.37 0.002057 0.6276 0.34312 0.386228 0.308434 53 152 129 32 192 191 rs7621663 Imputed G REC 749 2.257 0.239 1.413 3.606 3.406 0.000658 0.6276 0.34312 0.386228 0.308434 53 152 129 32 192 191 rs7626584 Imputed G ADD 799 0.4778 0.2123 0.3152 0.7244 −3.478 0.000505 0.6111 0.07384 0.047619 0.095023 1 32 324 4 76 362 rs7684899 Imputed C ADD 800 0.7138 0.1326 0.5504 0.9257 −2.542 0.01103 0.03097 0.20625 0.179272 0.227991 10 108 239 14 174 255 rs7684899 Imputed C DOM 800 0.6634 0.1489 0.4955 0.8883 −2.756 0.005859 0.03097 0.20625 0.179272 0.227991 10 108 239 14 174 255 rs7701604 Imputed G ADD 800 0.2198 0.3906 0.1022 0.4726 −3.878 0.000105 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs7701604 Imputed G DOM 800 0.2258 0.4052 0.102 0.4995 −3.673 0.00024 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs7703676 Imputed C ADD 800 0.2198 0.3906 0.1022 0.4726 −3.878 0.000105 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs7703676 Imputed C DOM 800 0.2258 0.4052 0.102 0.4995 −3.673 0.00024 0.0147 0.03563 0.015406 0.051919 0 11 346 4 38 401 rs7708491 Imputed C REC 797 0.5462 0.1754 0.3873 0.7703 −3.448 0.000565 1 0.48934 0.443662 0.526018 64 187 104 127 211 104 rs7711358 Imputed A DOM 797 0.6489 0.1462 0.4872 0.8644 −2.957 0.003109 0.7533 0.34316 0.314607 0.366213 44 136 176 52 219 170 rs7719448 Imputed G REC 796 0.525 0.1769 0.3712 0.7425 −3.643 0.000269 1 0.48807 0.440678 0.526018 62 188 104 127 211 104 rs7724761 Imputed T REC 795 0.528 0.177 0.3733 0.7469 −3.609 0.000307 1 0.48805 0.44051 0.526018 62 187 104 127 211 104 rs7742476 Imputed T DOM 734 1.752 0.1551 1.293 2.374 3.615 0.0003 0.1575 0.21662 0.255319 0.185185 20 128 181 21 108 276 rs7762993 Imputed A ADD 797 1.568 0.1276 1.221 2.013 3.524 0.000425 0.3626 0.19322 0.232394 0.161765 17 131 207 17 109 316 rs7762993 Imputed A DOM 797 1.808 0.1517 1.343 2.434 3.904 9.47E−05 0.3626 0.19322 0.232394 0.161765 17 131 207 17 109 316 rs7767265 Imputed G ADD 794 1.626 0.1195 1.287 2.056 4.068 4.74E−05 0.1075 0.22922 0.27762 0.190476 27 142 184 23 122 296 rs7767265 Imputed G DOM 794 1.904 0.1484 1.424 2.547 4.34 1.43E−05 0.1075 0.22922 0.27762 0.190476 27 142 184 23 122 296 rs7768128 Imputed G REC 768 0.3796 0.3438 0.1935 0.7448 −2.817 0.004846 0.2237 0.23112 0.222063 0.238663 12 131 206 35 130 254 rs7771264 Imputed T DOM 769 0.6735 0.1496 0.5024 0.9029 −2.643 0.008215 0.5527 0.23927 0.209677 0.26285 18 107 216 29 167 232 rs7773151 Geno- C DOM 800 0.6804 0.1475 0.5096 0.9086 −2.61 0.009059 0.3706 0.23063 0.20028 0.255079 17 109 231 30 166 247 typed rs7773210 Geno- A DOM 800 0.6745 0.1474 0.5052 0.9004 −2.672 0.007537 0.4259 0.23125 0.20028 0.256208 17 109 231 30 167 246 typed rs7808536 Imputed G DOM 793 1.395 0.1494 1.041 1.87 2.231 0.02571 0.5044 0.19924 0.21875 0.183673 11 132 209 17 128 296 rs7843510 Geno- G DOM 800 1.623 0.1544 1.199 2.197 3.137 0.001708 0.6638 0.42125 0.446779 0.400677 63 193 101 82 191 170 typed rs7894867 Imputed T DOM 795 1.6 0.1731 1.14 2.247 2.717 0.00659 0.4039 0.12075 0.142655 0.103175 7 87 260 7 77 357 rs7921834 Imputed C DOM 798 1.614 0.1449 1.215 2.144 3.304 0.000953 0.8644 0.29261 0.32493 0.26644 30 172 155 37 161 243 rs7939893 Imputed C ADD 792 0.7358 0.1051 0.5988 0.904 −2.92 0.003502 0.01403 0.33965 0.3 0.371854 38 137 180 69 187 181 rs7939893 Imputed C DOM 792 0.6755 0.145 0.5084 0.8976 −2.705 0.006832 0.01403 0.33965 0.3 0.371854 38 137 180 69 187 181 rs7944513 Imputed T GEN 790 13.06 0.001463 0.5615 0.24304 0.271307 0.22032 31 129 192 12 169 257 rs7944513 Imputed T REC 790 3.574 0.3533 1.788 7.143 3.605 0.000313 0.5615 0.24304 0.271307 0.22032 31 129 192 12 169 257 rs7949720 Imputed G ADD 756 0.57 0.1619 0.415 0.7828 −3.472 0.000516 0.8773 0.13624 0.102985 0.162708 5 59 271 8 121 292 rs7949720 Imputed G DOM 756 0.5191 0.1768 0.3671 0.7341 −3.708 0.000209 0.8773 0.13624 0.102985 0.162708 5 59 271 8 121 292 rs7955901 Imputed C ADD 786 0.7383 0.1058 0.6 0.9085 −2.867 0.004143 0.389 0.4542 0.416193 0.485023 60 173 119 96 229 109 rs7955901 Imputed C DOM 786 0.6461 0.1592 0.4729 0.8826 −2.744 0.006061 0.389 0.4542 0.416193 0.485023 60 173 119 96 229 109 rs7956274 Imputed T ADD 795 0.7286 0.1054 0.5926 0.8957 −3.005 0.002655 0.4324 0.46101 0.421127 0.493182 63 173 119 100 234 106 rs7956274 Imputed T DOM 795 0.6184 0.1596 0.4523 0.8456 −3.011 0.002605 0.4324 0.46101 0.421127 0.493182 63 173 119 100 234 106 rs7956274 Imputed T GEN 795 9.858 0.007235 0.4324 0.46101 0.421127 0.493182 63 173 119 100 234 106 rs7957932 Imputed G ADD 796 0.7518 0.1046 0.6125 0.9228 −2.729 0.006355 0.5703 0.47173 0.435211 0.501134 69 171 115 104 234 103 rs7957932 Imputed G DOM 796 0.6254 0.1609 0.4562 0.8572 −2.918 0.003526 0.5703 0.47173 0.435211 0.501134 69 171 115 104 234 103 rs7984504 Imputed C GEN 800 11.72 0.002847 0.1757 0.2975 0.341737 0.261851 45 154 158 34 164 245 rs7999518 Imputed A REC 738 0.6515 0.1778 0.4598 0.9232 −2.409 0.01598 0.2381 0.48238 0.459877 0.5 65 168 91 115 184 115 rs8026245 Imputed G GEN 778 8.696 0.01294 1 0.20373 0.227666 0.184455 22 114 211 10 139 282 rs8026245 Imputed G REC 778 3.097 0.3961 1.425 6.731 2.854 0.004317 1 0.20373 0.227666 0.184455 22 114 211 10 139 282 rs8060725 Geno- A ADD 800 0.7255 0.1166 0.5772 0.9118 −2.752 0.005931 0.09267 0.30125 0.266106 0.329571 18 154 185 44 204 195 typed rs8103016 Geno- A ADD 800 1.537 0.1267 1.199 1.97 3.391 0.000697 0.5109 0.2025 0.239496 0.172686 22 127 208 14 125 304 typed rs8103016 Geno- A DOM 800 1.604 0.1508 1.194 2.156 3.135 0.001718 0.5109 0.2025 0.239496 0.172686 22 127 208 14 125 304 typed rs8104182 Imputed G ADD 799 1.45 0.1279 1.129 1.863 2.906 0.00366 0.4289 0.19462 0.226124 0.1693 20 121 215 14 122 307 rs8104182 Imputed G DOM 799 1.504 0.1519 1.117 2.025 2.686 0.007239 0.4289 0.19462 0.226124 0.1693 20 121 215 14 122 307 rs8129461 Imputed G ADD 800 0.3701 0.3146 0.1998 0.6857 −3.159 0.001582 0.3047 0.0375 0.019608 0.051919 1 12 344 1 44 398 rs8129461 Imputed G DOM 800 0.3345 0.3297 0.1753 0.6385 −3.321 0.000898 0.3047 0.0375 0.019608 0.051919 1 12 344 1 44 398 rs8130021 Imputed G ADD 800 0.3701 0.3146 0.1998 0.6857 −3.159 0.001582 0.3047 0.0375 0.019608 0.051919 1 12 344 1 44 398 rs8130021 Imputed G DOM 800 0.3345 0.3297 0.1753 0.6385 −3.321 0.000898 0.3047 0.0375 0.019608 0.051919 1 12 344 1 44 398 rs879961 Imputed T ADD 791 0.6288 0.1219 0.4951 0.7985 −3.805 0.000142 0.8526 0.2579 0.210826 0.295455 14 120 217 37 186 217 rs879961 Imputed T DOM 791 0.6015 0.1465 0.4513 0.8016 −3.469 0.000522 0.8526 0.2579 0.210826 0.295455 14 120 217 37 186 217 rs906353 Imputed A DOM 795 0.622 0.1448 0.4683 0.8261 −3.279 0.001041 0.6019 0.28428 0.239496 0.320776 19 133 205 42 197 199 rs915491 Imputed C DOM 800 1.594 0.145 1.2 2.119 3.217 0.001297 0.7887 0.27188 0.302521 0.247178 25 166 166 32 155 256 rs915493 Imputed T DOM 800 1.594 0.145 1.2 2.119 3.217 0.001297 0.7887 0.27188 0.302521 0.247178 25 166 166 32 155 256 rs915494 Imputed A ADD 796 1.39 0.114 1.112 1.738 2.888 0.003875 0.932 0.2946 0.329577 0.26644 32 170 153 36 163 242 rs915494 Imputed A DOM 796 1.637 0.146 1.229 2.179 3.375 0.000738 0.932 0.2946 0.329577 0.26644 32 170 153 36 163 242 rs917295 Imputed G DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.8149 0.34563 0.317927 0.367946 44 139 174 53 220 170 rs9284851 Imputed A GEN 794 10.63 0.004929 0.7057 0.3772 0.415014 0.346939 65 163 125 45 216 180 rs9293464 Imputed T REC 796 0.525 0.1769 0.3712 0.7425 −3.643 0.000269 1 0.48807 0.440678 0.526018 62 188 104 127 211 104 rs9295154 Geno- G DOM 800 1.438 0.161 1.049 1.972 2.255 0.02411 0.5656 0.14375 0.165266 0.126411 8 102 247 6 100 337 typed rs9310221 Imputed A DOM 747 1.847 0.1614 1.346 2.534 3.801 0.000144 0.2965 0.42838 0.465774 0.39781 66 181 89 78 171 162 rs9310699 Geno- T GEN 800 9.296 0.009578 0.7594 0.36125 0.397759 0.331828 60 164 133 42 210 191 typed rs9310700 Imputed C ADD 771 1.383 0.1116 1.111 1.721 2.907 0.003644 0.4286 0.35019 0.390671 0.317757 54 160 129 35 202 191 rs9310700 Imputed C GEN 771 10.95 0.004186 0.4286 0.35019 0.390671 0.317757 54 160 129 35 202 191 rs9310701 Imputed G GEN 797 9.958 0.00688 0.821 0.37641 0.412676 0.347285 65 163 127 46 215 181 rs9310704 Imputed G GEN 784 11.11 0.003861 0.6466 0.37181 0.410511 0.340278 63 163 126 42 210 180 rs9319185 Imputed C GEN 790 12.94 0.001552 0.3434 0.29177 0.338028 0.254023 43 154 158 30 161 244 rs9319186 Imputed T GEN 795 12.3 0.002134 0.2253 0.28616 0.331461 0.249431 42 152 162 30 159 250 rs9327555 Imputed T DOM 800 0.6617 0.1466 0.4964 0.882 −2.816 0.004859 0.8149 0.34563 0.317927 0.367946 44 139 174 53 220 170 rs9403367 Imputed C DOM 800 0.6745 0.1474 0.5052 0.9004 −2.672 0.007537 0.4259 0.23125 0.20028 0.256208 17 109 231 30 167 246 rs9419608 Imputed G REC 797 1.836 0.1694 1.317 2.559 3.586 0.000336 0.9435 0.48996 0.533708 0.454649 108 164 84 84 233 124 rs9426437 Imputed T DOM 760 0.5666 0.1548 0.4183 0.7675 −3.669 0.000244 0.5994 0.40921 0.3739 0.437947 59 137 145 72 223 124 rs9454967 Imputed G DOM 799 1.856 0.1976 1.26 2.734 3.131 0.001743 0.8332 0.09199 0.115169 0.073363 4 74 278 3 59 381 rs9635511 Imputed T DOM 791 0.5722 0.1505 0.4297 0.7753 −3.651 0.000262 0.7663 0.39444 0.351275 0.429224 50 148 155 75 226 137 rs966583 Imputed A ADD 795 0.7274 0.1066 0.5903 0.8964 −2.987 0.002819 1 0.39371 0.355932 0.424036 49 154 151 74 226 141 rs966583 Imputed A DOM 795 0.6077 0.151 0.452 0.817 −3.298 0.000973 1 0.39371 0.355932 0.424036 49 154 151 74 226 141 rs980263 Imputed T GEN 796 10.4 0.00552 0.7627 0.37563 0.412676 0.345805 65 163 127 45 215 181 rs980264 Imputed T GEN 796 10.4 0.00552 0.7627 0.37563 0.412676 0.345805 65 163 127 45 215 181 rs9812206 Imputed G ADD 799 0.526 0.1802 0.3695 0.7488 −3.565 0.000364 0.4346 0.10075 0.070028 0.125566 3 44 310 7 97 338 rs9812206 Imputed G DOM 799 0.4862 0.1936 0.3327 0.7106 −3.725 0.000196 0.4346 0.10075 0.070028 0.125566 3 44 310 7 97 338 rs9813552 Imputed G ADD 800 0.5703 0.1786 0.4019 0.8093 −3.145 0.001661 0.6984 0.10125 0.07423 0.123025 3 47 307 6 97 340 rs9813552 Imputed G DOM 800 0.5318 0.191 0.3657 0.7733 −3.306 0.000946 0.6984 0.10125 0.07423 0.123025 3 47 307 6 97 340 rs9815037 Imputed T ADD 799 0.5621 0.1845 0.3915 0.8069 −3.123 0.001792 0.6789 0.09449 0.06882 0.115124 3 43 310 5 92 346 rs9815037 Imputed T DOM 799 0.5176 0.1969 0.3519 0.7613 −3.345 0.000822 0.6789 0.09449 0.06882 0.115124 3 43 310 5 92 346 rs9819583 Imputed T GEN 798 9.421 0.008999 0.7593 0.36153 0.398876 0.331448 60 164 132 42 209 191 rs9825349 Imputed A ADD 798 0.5607 0.1845 0.3906 0.8049 −3.136 0.001712 0.6792 0.09461 0.06882 0.115385 3 43 310 5 92 345 rs9825349 Imputed A DOM 798 0.5163 0.1969 0.351 0.7593 −3.358 0.000784 0.6792 0.09461 0.06882 0.115385 3 43 310 5 92 345 rs9833118 Imputed G ADD 794 1.352 0.1082 1.094 1.672 2.791 0.005247 0.4927 0.3665 0.404494 0.335616 60 168 128 42 210 186 rs9833118 Imputed G GEN 794 9.638 0.008076 0.4927 0.3665 0.404494 0.335616 60 168 128 42 210 186 rs9834217 Imputed T ADD 799 0.5621 0.1845 0.3915 0.8069 −3.123 0.001792 0.6789 0.09449 0.06882 0.115124 3 43 310 5 92 346 rs9834217 Imputed T DOM 799 0.5176 0.1969 0.3519 0.7613 −3.345 0.000822 0.6789 0.09449 0.06882 0.115124 3 43 310 5 92 346 rs9838563 Imputed C GEN 797 9.958 0.00688 0.821 0.37641 0.412676 0.347285 65 163 127 46 215 181 rs9840460 Imputed T ADD 799 0.5621 0.1845 0.3915 0.8069 −3.123 0.001792 0.6789 0.09449 0.06882 0.115124 3 43 310 5 92 346 rs9840460 Imputed T DOM 799 0.5176 0.1969 0.3519 0.7613 −3.345 0.000822 0.6789 0.09449 0.06882 0.115124 3 43 310 5 92 346 rs9840756 Imputed A ADD 799 0.5621 0.1845 0.3915 0.8069 −3.123 0.001792 0.6789 0.09449 0.06882 0.115124 3 43 310 5 92 346 rs9840756 Imputed A DOM 799 0.5176 0.1969 0.3519 0.7613 −3.345 0.000822 0.6789 0.09449 0.06882 0.115124 3 43 310 5 92 346 rs9847999 Imputed C GEN 794 10.29 0.005829 0.7623 0.37657 0.412429 0.347727 65 162 127 45 216 179 rs9864769 Imputed C GEN 797 9.958 0.00688 0.821 0.37641 0.412676 0.347285 65 163 127 46 215 181 rs9866421 Geno- C REC 800 0.5528 0.191 0.3802 0.8038 −3.104 0.00191 0.6672 0.44063 0.411765 0.463883 50 194 113 102 207 134 typed rs987296 Imputed T GEN 800 9.296 0.009578 0.7594 0.36125 0.397759 0.331828 60 164 133 42 210 191 rs9881685 Imputed A ADD 799 0.526 0.1802 0.3695 0.7488 −3.565 0.000364 0.4346 0.10075 0.070028 0.125566 3 44 310 7 97 338 rs9881685 Imputed A DOM 799 0.4862 0.1936 0.3327 0.7106 −3.725 0.000196 0.4346 0.10075 0.070028 0.125566 3 44 310 7 97 338 rs992695 Imputed C ADD 790 0.6317 0.1218 0.4976 0.8019 −3.773 0.000161 0.7811 0.25949 0.212857 0.296591 14 121 215 37 187 216 rs992695 Imputed C DOM 790 0.6056 0.1463 0.4546 0.8068 −3.427 0.00061 0.7811 0.25949 0.212857 0.296591 14 121 215 37 187 216 rs9936999 Imputed G DOM 485 1.885 0.192 1.294 2.746 3.302 0.000961 0.4247 0.35052 0.389952 0.320652 22 119 68 33 111 132

TABLE 15 PRA- PRA- PLA- PLA- PRA- PLA- VA_ PRA- VA_ CEBO_ PLA- CEBO_ VA_ CEBO_ _A1_ VA_ A2_ A1_ CEBO_ A2_ AL- HW_ AL- AL- AL- HZ_ HET_ HZ_ HZ_ HET_ HZ_ SNP LELE MOD- PVA LELE_ LELE_ LELE_ CO- CO- CO- CO- CO- CO- rs # SOURCE (A1) EL NMISS OR SE L95 U95 STAT P LUE FREQ FREQ FREQ UNT UNT UNT UNT UNT UNT rs77638540 Genotyped T DOM 431 0.6846 0.4051 0.3095 1.515 −0.935 0.3497 0.407 0.0348 0.02717 0.04049 0 10 174 1 18 228 rs72746987 Genotyped A DOM 431 0.3415 0.4723 0.1353 0.8617 −2.275 0.02291 0.01335 0.03596 0.02174 0.04656 2 4 178 1 21 225 rs10021016 Genotyped G GEN 431 4.358 0.1131 0.8982 0.25174 0.28533 0.22672 17 71 96 11 90 146 rs10021016 Genotyped G REC 431 2.151 0.4014 0.9794 4.724 1.908 0.05637 0.8982 0.25174 0.28533 0.22672 17 71 96 11 90 146 rs10051148 Imputed C DOM 431 0.7035 0.1964 0.4787 1.034 −1.791 0.07336 0.8246 0.31903 0.29348 0.33806 19 70 95 26 115 106 rs10054055 Imputed T DOM 431 0.7019 0.1964 0.4777 1.031 −1.803 0.0714 0.9114 0.31439 0.28804 0.33401 18 70 96 25 115 107 rs10067895 Imputed A DOM 423 0.6884 0.1986 0.4665 1.016 −1.88 0.0601 0.8235 0.32151 0.29444 0.34156 19 68 93 26 114 103 rs10100725 Imputed C DOM 431 0.6909 0.2229 0.4464 1.069 −1.659 0.09719 1 0.14849 0.11957 0.17004 1 42 141 8 68 171 rs10128531 Imputed T ADD 422 1.446 0.1929 0.9906 2.11 1.911 0.05601 0.04404 0.17773 0.20718 0.1556 5 65 111 2 71 168 rs10181743 Imputed G ADD 419 1.259 0.1434 0.9504 1.668 1.605 0.1084 0.7667 0.44511 0.47727 0.42181 42 84 50 39 127 77 rs10199127 Imputed T DOM 426 1.892 0.1994 1.28 2.797 3.197 0.00139 0.2788 0.277 0.32692 0.23975 14 91 77 14 89 141 rs10270624 Imputed G DOM 426 1.873 0.2081 1.245 2.816 3.014 0.00258 0.8741 0.18662 0.22826 0.15496 7 70 107 7 61 174 rs1030006 Imputed G REC 431 1.973 0.2532 1.201 3.24 2.684 0.00728 0.6962 0.43387 0.47826 0.40081 45 86 53 34 130 83 rs1031811 Imputed A REC 425 1.901 0.3376 0.9811 3.684 1.903 0.057 0.909 0.30471 0.32597 0.28893 23 72 86 17 107 120 rs10430870 Genotyped G GEN 431 1.662 0.4357 0.1902 0.24246 0.24457 0.24089 11 68 105 9 101 137 rs10430870 Genotyped G REC 431 1.672 0.4618 0.6765 4.134 1.114 0.2654 0.1902 0.24246 0.24457 0.24089 11 68 105 9 101 137 rs10469597 Imputed A GEN 397 5.33 0.06962 0.4689 0.29471 0.32941 0.26872 19 74 77 12 98 117 rs10469597 Imputed A REC 397 2.363 0.3863 1.108 5.039 2.226 0.02598 0.4689 0.29471 0.32941 0.26872 19 74 77 12 98 117 rs10478919 Imputed G DOM 431 0.7035 0.1964 0.4787 1.034 −1.791 0.07336 0.7398 0.32019 0.2962 0.33806 20 69 95 26 115 106 rs10506623 Imputed C ADD 431 0.6851 0.1503 0.5103 0.9198 −2.516 0.01187 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs10506623 Imputed C DOM 431 0.6216 0.2072 0.4141 0.9329 −2.295 0.02171 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs10506626 Imputed A ADD 430 0.644 0.1506 0.4794 0.8651 −2.922 0.00348 0.2655 0.39186 0.33424 0.43496 19 85 80 41 132 73 rs10506626 Imputed A DOM 430 0.5681 0.2056 0.3796 0.85 −2.75 0.00596 0.2655 0.39186 0.33424 0.43496 19 85 80 41 132 73 rs10509477 Imputed T DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs10517918 Imputed G REC 424 2.104 0.2569 1.272 3.481 2.896 0.00378 0.765 0.42099 0.46448 0.38797 45 80 58 32 123 86 rs10517924 Imputed A REC 430 1.646 0.2374 1.033 2.621 2.098 0.03593 0.9228 0.46512 0.49454 0.44332 48 85 50 44 131 72 rs10519362 Imputed G DOM 431 1.479 0.2285 0.9448 2.314 1.711 0.087 0.1367 0.13109 0.15489 0.11336 6 45 133 5 46 196 rs10520072 Imputed T DOM 429 0.6749 0.197 0.4587 0.993 −1.996 0.04596 1 0.31585 0.28689 0.3374 18 69 96 25 116 105 rs10737390 Imputed T DOM 426 0.6833 0.203 0.459 1.017 −1.876 0.06061 0.7588 0.38498 0.35714 0.40574 25 80 77 36 126 82 rs10742851 Imputed T REC 431 0.2879 0.5067 0.1066 0.7773 −2.457 0.014 0.8969 0.2471 0.2038 0.27935 5 65 114 22 94 131 rs10743685 Imputed G GEN 431 4.792 0.0911 0.9175 0.36543 0.40217 0.33806 30 88 66 28 111 108 rs10743685 Imputed G REC 431 1.602 0.2855 0.9156 2.803 1.651 0.09875 0.9175 0.36543 0.40217 0.33806 30 88 66 28 111 108 rs10749293 Imputed G DOM 431 1.52 0.1971 1.033 2.237 2.125 0.03357 0.4125 0.29002 0.32065 0.26721 18 82 84 22 88 137 rs10749294 Imputed A DOM 431 1.505 0.1973 1.022 2.216 2.073 0.03821 0.3324 0.27262 0.29891 0.25304 15 80 89 21 83 143 rs10753760 Imputed T ADD 406 1.468 0.1459 1.103 1.954 2.632 0.00849 0.6768 0.39039 0.44253 0.35129 35 84 55 29 105 98 rs10753760 Imputed T GEN 406 6.957 0.03085 0.6768 0.39039 0.44253 0.35129 35 84 55 29 105 98 rs10772362 Imputed T ADD 431 0.6724 0.1684 0.4834 0.9355 −2.356 0.01848 0.6967 0.24594 0.20652 0.2753 7 62 115 17 102 128 rs10784891 Imputed C ADD 429 0.7576 0.1448 0.5705 1.006 −1.918 0.05515 0.4895 0.42657 0.38736 0.45547 30 81 71 44 137 66 rs10784891 Imputed C DOM 429 0.5886 0.2107 0.3895 0.8896 −2.516 0.01189 0.4895 0.42657 0.38736 0.45547 30 81 71 44 137 66 rs10784891 Imputed C GEN 429 6.516 0.03846 0.4895 0.42657 0.38736 0.45547 30 81 71 44 137 66 rs10787923 Imputed G DOM 430 1.509 0.1972 1.025 2.221 2.086 0.03699 0.4129 0.2907 0.32065 0.26829 18 82 84 22 88 136 rs10787924 Imputed T DOM 431 1.505 0.1973 1.022 2.216 2.073 0.03821 0.3324 0.27262 0.29891 0.25304 15 80 89 21 83 143 rs10787949 Imputed A DOM 430 1.433 0.1969 0.9742 2.108 1.827 0.06765 0.4183 0.29535 0.32337 0.27439 19 81 84 22 91 133 rs10787951 Imputed G DOM 430 1.433 0.1969 0.9742 2.108 1.827 0.06765 0.4183 0.29535 0.32337 0.27439 19 81 84 22 91 133 rs10787983 Imputed C DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs10794733 Imputed C ADD 421 0.7588 0.1519 0.5634 1.022 −1.818 0.06914 0.9124 0.33017 0.29558 0.35625 13 81 87 32 107 101 rs10818280 Imputed C DOM 426 0.6701 0.1985 0.4541 0.9889 −2.016 0.04375 0.2268 0.32864 0.30055 0.34979 17 76 90 23 124 96 rs10860586 Imputed A ADD 430 1.512 0.1414 1.146 1.995 2.923 0.00347 1 0.49186 0.55163 0.44715 57 89 38 47 126 73 rs10860586 Imputed A GEN 430 8.948 0.0114 1 0.49186 0.55163 0.44715 57 89 38 47 126 73 rs10870473 Imputed A ADD 182 0.6204 0.2357 0.3909 0.9846 −2.026 0.04278 0.4798 0.2967 0.2439 0.34 7 26 49 11 46 43 rs10870473 Imputed A DOM 182 0.4859 0.3065 0.2665 0.886 −2.355 0.01853 0.4798 0.2967 0.2439 0.34 7 26 49 11 46 43 rs10879240 Imputed C ADD 430 0.7653 0.1438 0.5773 1.014 −1.86 0.06286 5.55E−01 0.42674 0.38859 0.45528 31 81 72 44 136 66 rs10879240 Imputed C GEN 430 6.525 0.03829 0.5549 0.42674 0.38859 0.45528 31 81 72 44 136 66 rs10879242 Imputed A ADD 431 0.6996 0.1493 0.5222 0.9374 −2.393 0.0167 0.1622 0.40371 0.35598 0.43927 21 89 74 42 133 72 rs10879242 Imputed A DOM 431 0.6354 0.2073 0.4232 0.9539 −2.188 0.02869 0.1622 0.40371 0.35598 0.43927 21 89 74 42 133 72 rs10879245 Imputed G ADD 431 0.6996 0.1493 0.5222 0.9374 −2.393 0.0167 0.1622 0.40371 0.35598 0.43927 21 89 74 42 133 72 rs10879245 Imputed G DOM 431 0.6354 0.2073 0.4232 0.9539 −2.188 0.02869 0.1622 0.40371 0.35598 0.43927 21 89 74 42 133 72 rs10879249 Imputed T ADD 430 0.6776 0.1506 0.5044 0.9103 −2.584 0.00976 0.1092 0.40116 0.35054 0.43902 20 89 75 41 134 71 rs10879249 Imputed T DOM 430 0.6103 0.2074 0.4065 0.9164 −2.381 0.01726 0.1092 0.40116 0.35054 0.43902 20 89 75 41 134 71 rs10886429 Imputed A DOM 429 1.47 0.1974 0.9985 2.165 1.952 0.05092 0.4134 0.29138 0.31967 0.27033 18 81 84 22 89 135 rs10886449 Imputed G DOM 430 1.441 0.1971 0.9794 2.121 1.854 0.06367 0.3355 0.27674 0.30163 0.25813 16 79 89 21 85 140 rs10886451 Imputed G DOM 430 1.441 0.1971 0.9794 2.121 1.854 0.06367 0.3355 0.27674 0.30163 0.25813 16 79 89 21 85 140 rs10886452 Imputed A DOM 430 1.433 0.1969 0.9742 2.108 1.827 0.06765 0.4183 0.29535 0.32337 0.27439 19 81 84 22 91 133 rs10886456 Imputed G DOM 430 1.441 0.1971 0.9794 2.121 1.854 0.06367 0.3355 0.27674 0.30163 0.25813 16 79 89 21 85 140 rs10886463 Imputed C DOM 431 1.444 0.1968 0.9818 2.123 1.867 0.06193 0.4176 0.29466 0.32337 0.27328 19 81 84 22 91 134 rs10886465 Imputed A DOM 431 1.444 0.1968 0.9818 2.123 1.867 0.06193 0.3545 0.29582 0.32337 0.2753 19 81 84 23 90 134 rs10886526 Imputed C DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs10922903 Imputed C REC 430 0.6266 0.2724 0.3674 1.069 −1.716 0.08622 0.7664 0.41395 0.39946 0.4248 25 97 62 47 115 84 rs10941126 Imputed G ADD 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs10941126 Imputed G DOM 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs10947980 Imputed G ADD 431 0.6089 0.157 0.4476 0.8282 −3.161 0.00157 0.3433 0.28422 0.22554 0.32794 15 53 116 24 114 109 rs11059376 Imputed T ADD 412 1.592 0.1898 1.097 2.309 2.45 0.01428 0.8625 0.17233 0.21023 0.14407 7 60 109 4 60 172 rs11072995 Imputed T GEN 430 5.185 0.07483 0.5795 0.22209 0.2459 0.20445 15 60 108 8 85 154 rs11072995 Imputed T REC 430 2.796 0.4515 1.154 6.774 2.277 0.0228 0.5795 0.22209 0.2459 0.20445 15 60 108 8 85 154 rs11081202 Genotyped G GEN 431 6.987 0.0304 0.2973 0.29466 0.33152 0.26721 26 70 88 16 100 131 rs11081202 Genotyped G REC 431 2.426 0.3357 1.256 4.684 2.64 0.00829 0.2973 0.29466 0.33152 0.26721 26 70 88 16 100 131 rs110965 Imputed C GEN 413 4.153 0.1254 0.739 0.3293 0.36782 0.30126 22 84 68 21 102 116 rs11124962 Imputed A DOM 431 1.812 0.2023 1.219 2.693 2.937 0.00331 0.7696 0.20766 0.24728 0.17814 7 77 100 10 68 169 rs1116596 Imputed T DOM 431 0.7035 0.1964 0.4787 1.034 −1.791 0.07336 0.7398 0.32019 0.2962 0.33806 20 69 95 26 115 106 rs11178531 Imputed A ADD 431 0.7781 0.1437 0.5871 1.031 −1.746 0.0808 0.4337 0.43735 0.40217 0.46356 32 84 68 46 137 64 rs11178531 Imputed A DOM 431 0.6138 0.212 0.4051 0.93 −2.303 0.0213 0.4337 0.43735 0.40217 0.46356 32 84 68 46 137 64 rs11178583 Imputed A ADD 430 0.6776 0.1506 0.5044 0.9103 −2.584 0.00976 0.1092 0.40116 0.35054 0.43902 20 89 75 41 134 71 rs11178583 Imputed A DOM 430 0.6103 0.2074 0.4065 0.9164 −2.381 0.01726 0.1092 0.40116 0.35054 0.43902 20 89 75 41 134 71 rs11178589 Imputed T ADD 431 0.6759 0.1506 0.5031 0.908 −2.601 0.0093 0.1086 0.40139 0.35054 0.43927 20 89 75 41 135 71 rs11178589 Imputed T DOM 431 0.6066 0.2072 0.4042 0.9105 −2.413 0.01583 0.1086 0.40139 0.35054 0.43927 20 89 75 41 135 71 rs11178594 Imputed C ADD 431 0.6841 0.1503 0.5096 0.9184 −2.527 0.01152 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs11178594 Imputed C DOM 431 0.62 0.207 0.4133 0.9302 −2.31 0.0209 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs11178602 Imputed T ADD 431 0.6841 0.1503 0.5096 0.9184 −2.527 0.01152 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs11178602 Imputed T DOM 431 0.62 0.207 0.4133 0.9302 −2.31 0.0209 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs11178648 Imputed T ADD 431 0.6858 0.1487 0.5125 0.9178 −2.537 0.01119 0.3138 0.39559 0.34511 0.4332 21 85 78 41 132 74 rs11178648 Imputed T DOM 431 0.6021 0.2055 0.4025 0.9008 −2.468 0.01358 0.3138 0.39559 0.34511 0.4332 21 85 78 41 132 74 rs11198877 Imputed T DOM 431 1.444 0.1968 0.9818 2.123 1.867 0.06193 0.4176 0.29466 0.32337 0.27328 19 81 84 22 91 134 rs11198942 Imputed T DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs11221075 Imputed A ADD 426 0.7175 0.2252 0.4614 1.116 −1.474 0.1405 0.8093 0.11385 0.09669 0.12653 2 31 148 4 54 187 rs11242020 Imputed T DOM 430 0.7107 0.1967 0.4834 1.045 −1.736 0.08258 0.7399 0.32093 0.29781 0.33806 20 69 94 26 115 106 rs11242021 Imputed T DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs11242022 Imputed T DOM 428 0.6944 0.1971 0.4719 1.022 −1.85 0.06431 1 0.31659 0.28962 0.33673 18 70 95 25 115 105 rs11242023 Imputed T DOM 428 0.6944 0.1971 0.4719 1.022 −1.85 0.06431 1 0.31659 0.28962 0.33673 18 70 95 25 115 105 rs1149349 Imputed T DOM 431 1.606 0.2234 1.037 2.489 2.122 0.03382 1 0.13689 0.16033 0.11943 2 55 127 6 47 194 rs1149350 Imputed A ADD 430 1.546 0.1741 1.099 2.176 2.504 0.0123 0.1416 0.1814 0.22283 0.15041 9 64 111 10 54 182 rs1149350 Imputed A DOM 430 1.835 0.2102 1.215 2.77 2.886 0.0039 0.1416 0.1814 0.22283 0.15041 9 64 111 10 54 182 rs11576627 Imputed T ADD 427 1.4 0.1931 0.9592 2.045 1.744 0.08112 0.1506 0.13817 0.16298 0.11992 7 45 129 5 49 192 rs11576627 Imputed T DOM 427 1.426 0.2259 0.9158 2.22 1.571 0.1162 0.1506 0.13817 0.16298 0.11992 7 45 129 5 49 192 rs11630050 Imputed G GEN 431 6.07 0.04808 0.7883 0.23202 0.25272 0.2166 16 61 107 8 91 148 rs11630050 Imputed G REC 431 2.977 0.4471 1.239 7.15 2.44 0.01469 0.7883 0.23202 0.25272 0.2166 16 61 107 8 91 148 rs11633024 Imputed C GEN 431 6.07 0.04808 0.7883 0.23202 0.25272 0.2166 16 61 107 8 91 148 rs11633024 Imputed C REC 431 2.977 0.4471 1.239 7.15 2.44 0.01469 0.7883 0.23202 0.25272 0.2166 16 61 107 8 91 148 rs11636298 Imputed G GEN 431 6.084 0.04773 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs11636298 Imputed G REC 431 3.183 0.4709 1.265 8.011 2.459 0.01395 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs11637363 Imputed C GEN 430 6.108 0.04718 0.893 0.23372 0.25272 0.21951 16 61 107 8 92 146 rs11637363 Imputed C REC 430 2.964 0.4471 1.234 7.119 2.43 0.01509 0.893 0.23372 0.25272 0.21951 16 61 107 8 92 146 rs11637813 Imputed A GEN 431 6.07 0.04808 0.7883 0.23202 0.25272 0.2166 16 61 107 8 91 148 rs11637813 Imputed A REC 431 2.977 0.4471 1.239 7.15 2.44 0.01469 0.7883 0.23202 0.25272 0.2166 16 61 107 8 91 148 rs11638043 Imputed C GEN 430 6.108 0.04718 0.893 0.23372 0.25272 0.21951 16 61 107 8 92 146 rs11638043 Imputed C REC 430 2.964 0.4471 1.234 7.119 2.43 0.01509 0.893 0.23372 0.25272 0.21951 16 61 107 8 92 146 rs11638115 Imputed A GEN 430 5.185 0.07483 0.5795 0.22209 0.2459 0.20445 15 60 108 8 85 154 rs11638115 Imputed A REC 430 2.796 0.4515 1.154 6.774 2.277 0.0228 0.5795 0.22209 0.2459 0.20445 15 60 108 8 85 154 rs11638444 Imputed C GEN 431 6.093 0.04752 1 0.22506 0.25272 0.20445 15 63 106 7 87 153 rs11682946 Imputed A ADD 96 5.356 0.4472 2.229 12.87 3.753 0.00018 1 0.19792 0.32927 0.1 3 21 17 0 11 44 rs11682946 Imputed A DOM 96 5.538 0.4642 2.23 13.76 3.688 0.00023 1 0.19792 0.32927 0.1 3 21 17 0 11 44 rs11717157 Imputed T ADD 430 1.45 0.1393 1.104 1.906 2.67 0.00759 0.02491 0.34535 0.39946 0.30488 34 79 71 28 94 124 rs11717157 Imputed T GEN 430 7.13 0.0283 0.02491 0.34535 0.39946 0.30488 34 79 71 28 94 124 rs11724055 Imputed A DOM 431 0.7804 0.2073 0.5199 1.172 −1.196 0.2317 0.6351 0.18794 0.1712 0.2004 5 53 126 8 83 156 rs11743355 Imputed C ADD 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs11743355 Imputed C DOM 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs11746806 Imputed T ADD 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs11746806 Imputed T DOM 431 0.309 0.5694 0.1012 0.9434 2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs11746959 Imputed T ADD 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs11746959 Imputed T DOM 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs11749272 Imputed T DOM 431 0.7035 0.1964 0.4787 1.034 −1.791 0.07336 0.7398 0.32019 0.2962 0.33806 20 69 95 26 115 106 rs11839636 Imputed C GEN 431 7.984 0.01846 0.5855 0.32831 0.3587 0.30567 30 72 82 19 113 115 rs11839785 Imputed C GEN 431 7.984 0.01846 0.5855 0.32831 0.3587 0.30567 30 72 82 19 113 115 rs11853619 Imputed C GEN 431 6.084 0.04773 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs11853619 Imputed C REC 431 3.183 0.4709 1.265 8.011 2.459 0.01395 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs11856780 Imputed A GEN 431 6.084 0.04773 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs11856780 Imputed A REC 431 3.183 0.4709 1.265 8.011 2.459 0.01395 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs11901899 Imputed A DOM 426 1.822 0.199 1.234 2.692 3.016 0.00256 0.5562 0.28873 0.34254 0.24898 20 84 77 18 86 141 rs11903290 Imputed C REC 425 1.901 0.3376 0.9811 3.684 1.903 0.057 0.909 0.30471 0.32597 0.28893 23 72 86 17 107 120 rs11909480 Imputed G ADD 431 0.5964 0.404 0.2701 1.317 −1.279 0.2008 0.3857 0.03364 0.02446 0.04049 0 9 175 1 18 228 rs11909480 Imputed G DOM 431 0.61 0.4187 0.2685 1.386 −1.181 0.2377 0.3857 0.03364 0.02446 0.04049 0 9 175 1 18 228 rs11910289 Imputed T ADD 428 2.254 0.3513 1.132 4.487 2.313 0.02074 0.5361 0.04206 0.06011 0.02857 1 20 162 0 14 231 rs11910289 Imputed T DOM 428 2.226 0.3621 1.095 4.527 2.21 0.02707 0.5361 0.04206 0.06011 0.02857 1 20 162 0 14 231 rs11920375 Genotyped C GEN 431 6.381 0.04115 0.02563 0.34571 0.39674 0.30769 33 80 71 29 94 124 rs11926319 Imputed G DOM 429 0.5229 0.2621 0.3128 0.874 −2.474 0.01336 0.7867 0.10023 0.07065 0.12245 0 26 158 3 54 188 rs11933744 Imputed T REC 431 3.01 0.47 1.198 7.563 2.345 0.01904 1 0.22738 0.25272 0.2085 15 63 106 7 89 151 rs11934919 Imputed C REC 431 3.01 0.47 1.198 7.563 2.345 0.01904 1 0.22738 0.25272 0.2085 15 63 106 7 89 151 rs11934957 Imputed C REC 431 3.01 0.47 1.198 7.563 2.345 0.01904 1 0.22738 0.25272 0.2085 15 63 106 7 89 151 rs11959206 Imputed A REC 428 0.5862 0.2628 0.3502 0.9812 −2.032 0.04213 0.3793 0.44509 0.42896 0.45714 26 105 52 54 116 75 rs12038613 Imputed C REC 429 0.5999 0.2756 0.3495 1.03 −1.854 0.06381 0.6194 0.41492 0.39891 0.42683 24 98 61 47 116 83 rs12151417 Imputed T DOM 428 1.573 0.1977 1.067 2.317 2.29 0.02204 0.04209 0.28037 0.32418 0.24797 15 88 79 10 102 134 rs12153185 Imputed T DOM 426 0.6973 0.1977 0.4733 1.027 −1.824 0.06815 0.8238 0.32042 0.29396 0.34016 19 69 94 26 114 104 rs12182651 Imputed T DOM 431 2.24 0.3143 1.21 4.147 2.566 0.0103 0.1777 0.05916 0.08152 0.04251 1 28 155 2 17 228 rs12235345 Imputed C DOM 430 1.42 0.2727 0.8321 2.423 1.286 0.1985 1 0.07674 0.08696 0.06911 0 32 152 2 30 214 rs12324786 Imputed T GEN 430 5.185 0.07483 0.5795 0.22209 0.2459 0.20445 15 60 108 8 85 154 rs12324786 Imputed T REC 430 2.796 0.4515 1.154 6.774 2.277 0.0228 0.5795 0.22209 0.2459 0.20445 15 60 108 8 85 154 rs12336958 Imputed G DOM 403 1.46 0.211 0.9657 2.208 1.794 0.07276 0.3339 0.366 0.39759 0.34388 22 88 56 27 109 101 rs12407412 Imputed C ADD 431 1.382 0.1928 0.9468 2.016 1.676 0.09367 0.1056 0.13689 0.16033 0.11943 7 45 132 5 49 193 rs12407412 Imputed C DOM 431 1.401 0.2256 0.9007 2.181 1.496 0.1346 0.1056 0.13689 0.16033 0.11943 7 45 132 5 49 193 rs12418971 Imputed C GEN 423 1.464 0.481 0.2341 0.24232 0.2486 0.2377 11 67 101 9 98 137 rs12418971 Imputed C REC 423 1.699 0.4623 0.6866 4.204 1.147 0.2515 0.2341 0.24232 0.2486 0.2377 11 67 101 9 98 137 rs1241967 Imputed T REC 431 0.5915 0.3332 0.3078 1.136 −1.576 0.115 0.519 0.33875 0.33152 0.34413 15 92 77 31 108 108 rs12420184 Imputed G DOM 430 0.6518 0.2209 0.4227 1.005 −1.938 0.05266 0.2101 0.16163 0.12772 0.18699 3 41 140 12 68 166 rs12433968 Imputed T DOM 396 0.7213 0.2052 0.4825 1.078 −1.592 0.1114 1 0.28914 0.26946 0.30349 15 60 92 18 103 108 rs12445477 Imputed A DOM 423 0.4063 0.2966 0.2272 0.7267 −3.036 0.0024 0.5364 0.08629 0.05307 0.11066 1 17 161 3 48 193 rs12447191 Genotyped T ADD 431 0.6489 0.1758 0.4598 0.9158 −2.461 0.01387 0.6616 0.20766 0.16848 0.23684 10 42 132 10 97 140 rs12447191 Genotyped T DOM 431 0.5081 0.2092 0.3372 0.7656 −3.237 0.00121 0.6616 0.20766 0.16848 0.23684 10 42 132 10 97 140 rs12465349 Imputed A REC 426 1.587 0.2245 1.022 2.464 2.056 0.03975 1 0.50587 0.55163 0.47107 56 91 37 53 122 67 rs1247340 Imputed C ADD 431 1.51 0.1734 1.075 2.122 2.377 0.01746 0.1479 0.18329 0.22283 0.15385 9 64 111 10 56 181 rs1247340 Imputed C DOM 431 1.767 0.2092 1.173 2.663 2.721 0.0065 0.1479 0.18329 0.22283 0.15385 9 64 111 10 56 181 rs1247341 Imputed C ADD 430 1.524 0.1738 1.084 2.143 2.426 0.01527 0.1445 0.18256 0.22283 0.15244 9 64 111 10 55 181 rs1247341 Imputed C DOM 430 1.795 0.2098 1.19 2.707 2.788 0.0053 0.1445 0.18256 0.22283 0.15244 9 64 111 10 55 181 rs1247343 Imputed C DOM 430 1.681 0.2249 1.081 2.612 2.308 0.02099 0.8388 0.13488 0.16033 0.11585 2 55 127 6 45 195 rs12509758 Imputed C DOM 430 1.856 0.204 1.244 2.768 3.03 0.00245 0.7673 0.20465 0.25543 0.16667 12 70 102 7 68 171 rs12515472 Imputed A DOM 431 1.531 0.205 1.024 2.287 2.076 0.03785 0.3479 0.18794 0.21196 0.17004 4 70 110 8 68 171 rs12548906 Imputed G ADD 420 1.496 0.1799 1.052 2.129 2.241 0.02504 0.1402 0.20833 0.24444 0.18125 7 74 99 6 75 159 rs12596240 Imputed G DOM 430 0.6708 0.2061 0.4479 1.005 −1.937 0.05268 0.08793 0.4 0.38043 0.41463 28 84 72 32 140 74 rs12618781 Imputed A DOM 407 0.5446 0.2216 0.3528 0.8408 −2.743 0.00609 0.7652 0.45332 0.41124 0.48319 32 75 62 50 130 58 rs12678600 Imputed A DOM 431 0.6479 0.1972 0.4402 0.9536 −2.201 0.02773 0.7429 0.32599 0.28261 0.3583 14 76 94 30 117 100 rs12692229 Imputed T ADD 430 1.315 0.1467 0.9861 1.753 1.864 0.06226 0.8275 0.33023 0.36413 0.30488 26 82 76 22 106 118 rs12713324 Imputed T DOM 427 1.584 0.1981 1.074 2.335 2.321 0.02028 0.08929 0.27518 0.31868 0.24286 15 86 81 10 99 136 rs12719415 Imputed T DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs12820589 Imputed G ADD 418 1.758 0.1836 1.227 2.519 3.073 0.00212 0.4989 0.17584 0.225 0.13866 9 63 108 6 54 178 rs12820589 Imputed G DOM 418 1.936 0.214 1.273 2.946 3.088 0.00202 0.4989 0.17584 0.225 0.13866 9 63 108 6 54 178 rs12831292 Imputed G ADD 431 0.6841 0.1503 0.5096 0.9184 −2.527 0.01152 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs12831292 Imputed G DOM 431 0.62 0.207 0.4133 0.9302 −2.31 0.0209 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs13012636 Imputed G REC 425 1.901 0.3376 0.9811 3.684 1.903 0.057 0.909 0.30471 0.32597 0.28893 23 72 86 17 107 120 rs13038146 Imputed C ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs13038146 Imputed C GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs13038146 Imputed C REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs13089860 Imputed A DOM 358 0.6221 0.23 0.3963 0.9764 −2.064 0.03904 0.02583 0.46229 0.41503 0.49756 32 63 58 55 94 56 rs13102419 Imputed T REC 429 1.668 0.2387 1.045 2.663 2.144 0.03201 0.7714 0.46503 0.49728 0.44082 48 87 49 43 130 72 rs13194907 Imputed A ADD 431 1.964 0.3063 1.077 3.579 2.203 0.02757 1 0.05568 0.07609 0.04049 0 28 156 1 18 228 rs13194907 Imputed A DOM 431 2.136 0.3162 1.15 3.97 2.401 0.01635 1 0.05568 0.07609 0.04049 0 28 156 1 18 228 rs13195745 Imputed A ADD 431 1.964 0.3063 1.077 3.579 2.203 0.02757 1 0.05568 0.07609 0.04049 0 28 156 1 18 228 rs13195745 Imputed A DOM 431 2.136 0.3162 1.15 3.97 2.401 0.01635 1 0.05568 0.07609 0.04049 0 28 156 1 18 228 rs13265054 Imputed T DOM 421 0.6754 0.199 0.4573 0.9976 −1.972 0.04863 0.8246 0.32423 0.28453 0.35417 14 75 92 29 112 99 rs13273002 Imputed A GEN 429 3.598 0.1655 0.88 0.19814 0.1712 0.21837 3 57 124 13 81 151 rs13282131 Imputed C ADD 431 1.415 0.1363 1.084 1.849 2.549 0.0108 0.2104 0.47332 0.52446 0.43522 53 87 44 50 115 82 rs13282131 Imputed C GEN 431 6.498 0.03882 0.2104 0.47332 0.52446 0.43522 53 87 44 50 115 82 rs13282131 Imputed C REC 431 1.595 0.2279 1.02 2.493 2.048 0.04058 0.2104 0.47332 0.52446 0.43522 53 87 44 50 115 82 rs1330052 Imputed G GEN 431 11.32 0.00349 0.4097 0.37007 0.39674 0.3502 38 70 76 25 123 99 rs1335721 Imputed A REC 429 0.5999 0.2756 0.3495 1.03 −1.854 0.06381 0.6194 0.41492 0.39891 0.42683 24 98 61 47 116 83 rs1336382 Imputed T DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs1336383 Imputed T DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs1336407 Imputed T DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs1336409 Imputed T DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs1336596 Imputed A DOM 430 0.6728 0.2004 0.4543 0.9965 −1.978 0.04797 0.2989 0.36512 0.33967 0.38415 23 79 82 29 131 86 rs13387284 Imputed A DOM 400 0.5278 0.2223 0.3414 0.816 −2.875 0.00404 0.7625 0.44625 0.39458 0.48291 28 75 63 50 126 58 rs13401462 Imputed C DOM 424 2.137 0.2339 1.351 3.38 3.245 0.00117 0.6266 0.48113 0.53352 0.44286 47 97 35 54 109 82 rs13409045 Imputed T ADD 431 0.6931 0.1457 0.521 0.9221 −2.517 0.01184 0.6898 0.40371 0.35598 0.43927 22 87 75 46 125 76 rs1349284 Imputed C GEN 431 7.563 0.02279 0.04132 0.34107 0.39674 0.2996 33 80 71 27 94 126 rs1355715 Imputed T ADD 430 0.5755 0.3625 0.2828 1.171 −1.524 0.1275 1 0.04535 0.03261 0.05488 0 12 172 0 27 219 rs1357696 Imputed A GEN 426 5.96 0.05078 0.03445 0.35563 0.40489 0.31818 34 81 69 30 94 118 rs1357698 Imputed A GEN 426 5.96 0.05078 0.03445 0.35563 0.40489 0.31818 34 81 69 30 94 118 rs1357699 Imputed T GEN 426 5.96 0.05078 0.03445 0.35563 0.40489 0.31818 34 81 69 30 94 118 rs1363273 Imputed C REC 404 0.5817 0.2679 0.344 0.9834 −2.023 0.04312 0.6881 0.44554 0.42105 0.46352 25 94 52 53 110 70 rs1373601 Imputed A DOM 400 0.5287 0.2065 0.3527 0.7925 −3.086 0.00203 0.00407 0.32125 0.27326 0.35746 23 48 101 31 101 96 rs1375829 Imputed C GEN 431 7.563 0.02279 0.04132 0.34107 0.39674 0.2996 33 80 71 27 94 126 rs1395748 Imputed G DOM 431 0.6603 0.1967 0.4491 0.9708 −2.11 0.03482 0.6452 0.29698 0.26902 0.31781 18 63 103 22 113 112 rs1414865 Imputed T DOM 430 1.433 0.1969 0.9742 2.108 1.827 0.06765 0.4183 0.29535 0.32337 0.27439 19 81 84 22 91 133 rs1414873 Imputed A DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs1414876 Imputed C DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs1424643 Imputed G ADD 423 1.554 0.1651 1.124 2.148 2.669 0.00761 0.0693 0.27896 0.32402 0.2459 15 86 78 10 100 134 rs1424643 Imputed G DOM 423 1.592 0.199 1.078 2.351 2.336 0.01947 0.0693 0.27896 0.32402 0.2459 15 86 78 10 100 134 rs1424648 Imputed T DOM 431 1.619 0.1972 1.1 2.383 2.444 0.01451 0.04199 0.28074 0.32065 0.25101 13 92 79 12 100 135 rs1429321 Imputed A DOM 426 1.545 0.1979 1.048 2.277 2.198 0.02793 0.04156 0.28169 0.32418 0.25 15 88 79 10 102 132 rs1429326 Imputed T ADD 423 1.514 0.1654 1.094 2.093 2.505 0.01223 0.08559 0.27305 0.31421 0.24167 14 87 82 10 96 134 rs1429326 Imputed T DOM 423 1.573 0.1984 1.066 2.321 2.284 0.02236 0.08559 0.27305 0.31421 0.24167 14 87 82 10 96 134 rs1444741 Imputed A DOM 407 0.5155 0.205 0.3449 0.7703 −3.233 0.00122 0.00416 0.31818 0.26857 0.3556 23 48 104 31 103 98 rs1449916 Imputed C DOM 338 0.4287 0.2519 0.2617 0.7025 −3.362 0.00077 0.3854 0.49556 0.41045 0.55147 25 60 49 62 101 41 rs1459523 Imputed A ADD 430 1.45 0.1393 1.104 1.906 2.67 0.00759 0.02491 0.34535 0.39946 0.30488 34 79 71 28 94 124 rs1459523 Imputed A GEN 430 7.13 0.0283 0.02491 0.34535 0.39946 0.30488 34 79 71 28 94 124 rs1466352 Imputed T GEN 431 6.792 0.0335 0.0334 0.34687 0.39946 0.30769 34 79 71 28 96 123 rs1466353 Imputed G GEN 431 6.792 0.0335 0.0334 0.34687 0.39946 0.30769 34 79 71 28 96 123 rs1476714 Imputed A DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs1486723 Imputed C REC 431 0.6161 0.3308 0.3222 1.178 −1.464 0.1431 0.6673 0.33875 0.33424 0.34211 15 93 76 32 105 110 rs1495375 Imputed A ADD 431 0.6996 0.1493 0.5222 0.9374 −2.393 0.0167 0.1622 0.40371 0.35598 0.43927 21 89 74 42 133 72 rs1495375 Imputed A DOM 431 0.6354 0.2073 0.4232 0.9539 −2.188 0.02869 0.1622 0.40371 0.35598 0.43927 21 89 74 42 133 72 rs1495381 Imputed T GEN 431 4.34 0.1142 0.9218 0.42923 0.45652 0.40891 43 82 59 37 128 82 rs1495381 Imputed T REC 431 1.661 0.2511 1.015 2.717 2.021 0.04331 0.9218 0.42923 0.45652 0.40891 43 82 59 37 128 82 rs1498061 Imputed C ADD 201 0.614 0.2646 0.3655 1.031 −1.843 0.06527 0.2527 0.19154 0.14881 0.22222 1 23 60 9 34 74 rs1498992 Imputed G DOM 430 0.7209 0.1965 0.4905 1.06 −1.666 0.09577 0.9083 0.29651 0.27174 0.31504 15 70 99 22 111 113 rs1499001 Imputed T DOM 428 0.7112 0.1982 0.4823 1.049 −1.719 0.08562 0.8032 0.26168 0.23913 0.27869 12 64 108 16 104 124 rs1512988 Imputed A ADD 429 0.6768 0.1508 0.5037 0.9096 −2.589 0.00964 0.1315 0.40093 0.34973 0.43902 20 88 75 41 134 71 rs1512988 Imputed A DOM 429 0.6068 0.2078 0.4038 0.9117 −2.405 0.01618 0.1315 0.40093 0.34973 0.43902 20 88 75 41 134 71 rs1512989 Imputed T ADD 429 0.6768 0.1508 0.5037 0.9096 −2.589 0.00964 0.1315 0.40093 0.34973 0.43902 20 88 75 41 134 71 rs1512989 Imputed T DOM 429 0.6068 0.2078 0.4038 0.9117 −2.405 0.01618 0.1315 0.40093 0.34973 0.43902 20 88 75 41 134 71 rs1512991 Imputed T ADD 431 0.7609 0.1446 0.5731 1.01 −1.89 0.05873 0.4308 0.42691 0.38859 0.45547 30 83 71 44 137 66 rs1512991 Imputed T DOM 431 0.5996 0.2103 0.3971 0.9055 −2.432 0.01501 0.4308 0.42691 0.38859 0.45547 30 83 71 44 137 66 rs1512991 Imputed T GEN 431 6.036 0.04889 0.4308 0.42691 0.38859 0.45547 30 83 71 44 137 66 rs1524303 Imputed T GEN 429 6.951 0.03095 0.02511 0.34615 0.39946 0.30612 34 79 71 28 94 123 rs1524306 Imputed C ADD 431 1.457 0.1392 1.109 1.914 2.705 0.00682 0.0248 0.34455 0.39946 0.30364 34 79 71 28 94 125 rs1524306 Imputed C GEN 431 7.32 0.02573 0.0248 0.34455 0.39946 0.30364 34 79 71 28 94 125 rs1524310 Imputed G ADD 428 1.471 0.1406 1.117 1.937 2.744 0.00606 0.04097 0.34229 0.39835 0.30081 33 79 70 27 94 125 rs1524310 Imputed G GEN 428 7.531 0.02315 0.04097 0.34229 0.39835 0.30081 33 79 70 27 94 125 rs1524321 Imputed C GEN 423 7.53 0.02317 0.06463 0.33806 0.39286 0.29668 32 79 71 25 93 123 rs1527059 Imputed A DOM 428 0.7558 0.266 0.4487 1.273 −1.052 0.2927 0.7591 0.08762 0.07418 0.09756 0 27 155 2 44 200 rs152707 Imputed A ADD 431 0.7681 0.1426 0.5808 1.016 −1.85 0.06428 0.7628 0.39559 0.36141 0.42105 25 83 76 44 120 83 rs152707 Imputed A GEN 431 3.606 0.1648 0.7628 0.39559 0.36141 0.42105 25 83 76 44 120 83 rs152712 Genotyped C ADD 431 0.7606 0.1429 0.5748 1.007 −1.914 0.05557 0.8406 0.39675 0.36141 0.42308 25 83 76 44 121 82 rs152712 Genotyped C GEN 431 3.917 0.1411 0.8406 0.39675 0.36141 0.42308 25 83 76 44 121 82 rs1533994 Imputed T GEN 431 6.792 0.0335 0.0334 0.34687 0.39946 0.30769 34 79 71 28 96 123 rs1535866 Imputed G DOM 431 1.83 0.206 1.222 2.74 2.933 0.00336 0.531 0.1891 0.22554 0.16194 5 73 106 8 64 175 rs1563773 Imputed T GEN 429 6.416 0.04044 0.04296 0.34848 0.39946 0.3102 34 79 71 28 96 121 rs1563774 Imputed T GEN 431 6.792 0.0335 0.0334 0.34687 0.39946 0.30769 34 79 71 28 96 123 rs1567740 Imputed T ADD 430 0.6776 0.1506 0.5044 0.9103 −2.584 0.00976 0.1092 0.40116 0.35054 0.43902 20 89 75 41 134 71 rs1567740 Imputed T DOM 430 0.6103 0.2074 0.4065 0.9164 −2.381 0.01726 0.1092 0.40116 0.35054 0.43902 20 89 75 41 134 71 rs1572573 Imputed A DOM 413 1.458 0.2093 0.9676 2.198 1.802 0.07148 0.1958 0.18523 0.20904 0.16737 4 66 107 6 67 163 rs1577497 Imputed C REC 429 0.5999 0.2756 0.3495 1.03 −1.854 0.06381 0.6194 0.41492 0.39891 0.42683 24 98 61 47 116 83 rs1581514 Imputed T ADD 418 1.482 0.1411 1.124 1.954 2.79 0.00527 0.0181 0.34928 0.4073 0.30625 34 77 67 28 91 121 rs1581514 Imputed T GEN 418 7.786 0.02039 0.0181 0.34928 0.4073 0.30625 34 77 67 28 91 121 rs1582321 Imputed T DOM 431 0.6673 0.206 0.4456 0.9992 −1.964 0.04955 0.08774 0.40023 0.38043 0.41498 28 84 72 32 141 74 rs1582322 Imputed A DOM 426 0.6832 0.2069 0.4554 1.025 −1.841 0.06568 0.107 0.40023 0.38187 0.41393 28 83 71 32 138 74 rs1582323 Imputed A DOM 427 0.6891 0.2068 0.4595 1.034 −1.8 0.07179 0.1066 0.40047 0.38251 0.41393 28 84 71 32 138 74 rs1592485 Imputed C DOM 430 0.6849 0.2064 0.4571 1.026 −1.834 0.06669 0.1326 0.40349 0.38315 0.4187 28 85 71 34 138 74 rs1600954 Imputed T ADD 418 1.458 0.1435 1.1 1.931 2.627 0.00863 0.9216 0.45574 0.50833 0.41597 48 87 45 38 122 78 rs1600954 Imputed T GEN 418 7.629 0.02204 0.9216 0.45574 0.50833 0.41597 48 87 45 38 122 78 rs16938626 Imputed G DOM 417 0.6482 0.201 0.4371 0.9612 −2.157 0.03103 0.5372 0.27218 0.23276 0.30041 9 63 102 19 108 116 rs16964300 Imputed G ADD 431 0.6489 0.1758 0.4598 0.9158 −2.461 0.01387 0.6616 0.20766 0.16848 0.23684 10 42 132 10 97 140 rs16964300 Imputed G DOM 431 0.5081 0.2092 0.3372 0.7656 −3.237 0.00121 0.6616 0.20766 0.16848 0.23684 10 42 132 10 97 140 rs16986282 Imputed G DOM 429 0.6518 0.4222 0.2849 1.491 −1.014 0.3106 0.3657 0.03263 0.02459 0.03862 0 9 174 1 17 228 rs17007620 Imputed G ADD 387 1.684 0.1701 1.206 2.35 3.063 0.00219 1 0.25452 0.30838 0.21364 14 75 78 11 72 137 rs17007620 Imputed G DOM 387 1.898 0.2093 1.259 2.861 3.062 0.0022 1 0.25452 0.30838 0.21364 14 75 78 11 72 137 rs17014326 Imputed G DOM 429 0.6773 0.1968 0.4605 0.9961 −1.98 0.04771 0.5678 0.30303 0.27717 0.32245 19 64 101 23 112 110 rs17047957 Imputed C DOM 430 1.575 0.2288 1.006 2.466 1.986 0.047 0.1374 0.1314 0.15847 0.11134 6 46 131 5 45 197 rs1705261 Imputed A REC 430 1.6 0.2523 0.9755 2.623 1.862 0.06263 0.7675 0.42442 0.44565 0.40854 42 80 62 37 127 82 rs17073341 Imputed A ADD 431 1.335 0.3929 0.618 2.883 0.735 0.4624 1 0.03248 0.03804 0.02834 0 14 170 0 14 233 rs17073341 Imputed A DOM 431 1.335 0.3929 0.618 2.883 0.735 0.4624 1 0.03248 0.03804 0.02834 0 14 170 0 14 233 rs17138702 Imputed G ADD 429 0.7112 0.2144 0.4672 1.083 −1.59 0.1119 0.6615 0.12704 0.10383 0.14431 1 36 146 7 57 182 rs17189710 Imputed T ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs17189710 Imputed T GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs17189710 Imputed T REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs17310176 Imputed T ADD 431 0.8153 0.1969 0.5542 1.199 −1.037 0.2997 0.02653 0.17053 0.15761 0.18016 2 54 128 4 81 162 rs17310176 Imputed T DOM 431 0.8122 0.2102 0.5379 1.226 −0.989 0.3224 0.02653 0.17053 0.15761 0.18016 2 54 128 4 81 162 rs17358860 Imputed A DOM 431 0.7804 0.2073 0.5199 1.172 −1.196 0.2317 0.6351 0.18794 0.1712 0.2004 5 53 126 8 83 156 rs17370541 Imputed T GEN 417 4.709 0.09495 0.9164 0.3693 0.38764 0.35565 31 76 71 25 120 94 rs17370541 Imputed T REC 417 1.782 0.2901 1.009 3.147 1.991 0.04643 0.9164 0.3693 0.38764 0.35565 31 76 71 25 120 94 rs17526574 Imputed G GEN 431 7.984 0.01846 0.5855 0.32831 0.3587 0.30567 30 72 82 19 113 115 rs17530747 Imputed T DOM 422 0.7249 0.1996 0.4902 1.072 −1.612 0.107 1 0.34834 0.33152 0.36134 24 74 86 27 118 93 rs17649114 Imputed C DOM 429 1.27 0.2011 0.8563 1.884 1.189 0.2346 0.7799 0.22145 0.24176 0.20648 10 68 104 12 78 157 rs17766172 Imputed A REC 419 0.6013 0.3147 0.3245 1.114 −1.616 0.1061 0.4468 0.3401 0.31768 0.35714 17 81 83 35 100 103 rs1818885 Imputed G GEN 431 7.055 0.02938 0.02563 0.34571 0.39946 0.30567 34 79 71 28 95 124 rs1832222 Imputed G DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs1861327 Imputed G DOM 431 0.6673 0.206 0.4456 0.9992 −1.964 0.04955 0.08774 0.40023 0.38043 0.41498 28 84 72 32 141 74 rs1868581 Imputed G ADD 431 1.471 0.1402 1.117 1.936 2.75 0.00596 0.04132 0.34107 0.39674 0.2996 33 80 71 27 94 126 rs1868581 Imputed G GEN 431 7.563 0.02279 0.04132 0.34107 0.39674 0.2996 33 80 71 27 94 126 rs1874313 Imputed A ADD 430 0.671 0.151 0.4991 0.9022 −2.642 0.00825 0.1082 0.40233 0.35054 0.44106 20 89 75 41 135 70 rs1874313 Imputed A DOM 430 0.5994 0.208 0.3987 0.9009 −2.462 0.01383 0.1082 0.40233 0.35054 0.44106 20 89 75 41 135 70 rs1876409 Imputed C DOM 428 0.6523 0.1975 0.443 0.9607 −2.163 0.03053 0.8167 0.29673 0.26923 0.31707 18 62 102 21 114 111 rs1913201 Imputed G ADD 429 0.7714 0.144 0.5817 1.023 −1.803 0.07146 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs1913201 Imputed G DOM 429 0.5986 0.2106 0.3961 0.9045 −2.436 0.01484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs1913201 Imputed G GEN 429 6.21 0.04484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs1916922 Imputed T GEN 415 6.677 0.03549 0.2165 0.32289 0.375 0.28452 27 78 71 22 92 125 rs1936871 Genotyped G DOM 431 0.7159 0.1987 0.485 1.057 −1.682 0.09248 0.4071 0.36659 0.3288 0.39474 21 79 84 41 113 93 rs1961157 Imputed T REC 431 0.4785 0.2451 0.296 0.7736 −3.007 0.00264 1 0.48376 0.42935 0.52429 30 98 56 71 117 59 rs1987179 Imputed T ADD 431 0.7399 0.1691 0.5312 1.031 −1.782 0.07475 0.8902 0.2239 0.19565 0.24494 10 52 122 12 97 138 rs1987179 Imputed T DOM 431 0.6359 0.2028 0.4273 0.9464 −2.232 0.02564 0.8902 0.2239 0.19565 0.24494 10 52 122 12 97 138 rs1990023 Imputed T DOM 431 0.7035 0.1964 0.4787 1.034 −1.791 0.07336 0.7398 0.32019 0.2962 0.33806 20 69 95 26 115 106 rs1995025 Imputed C DOM 431 1.335 0.2271 0.8555 2.084 1.273 0.203 0.674 0.12993 0.1413 0.12146 2 48 134 6 48 193 rs2016194 Imputed G DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs2023651 Imputed T ADD 429 0.5946 0.1842 0.4144 0.8532 −2.822 0.00477 0.7575 0.19347 0.14946 0.22653 3 49 132 14 83 148 rs2024902 Imputed A ADD 431 1.964 0.3063 1.077 3.579 2.203 0.02757 1 0.05568 0.07609 0.04049 0 28 156 1 18 228 rs2024902 Imputed A DOM 431 2.136 0.3162 1.15 3.97 2.401 0.01635 1 0.05568 0.07609 0.04049 0 28 156 1 18 228 rs2025107 Imputed A DOM 431 2.24 0.3143 1.21 4.147 2.566 0.0103 0.1777 0.05916 0.08152 0.04251 1 28 155 2 17 228 rs2025108 Imputed T DOM 431 2.069 0.3044 1.14 3.758 2.389 0.01687 0.2262 0.06265 0.08424 0.04656 1 29 154 2 19 226 rs2031987 Imputed T GEN 431 7.984 0.01846 0.5855 0.32831 0.3587 0.30567 30 72 82 19 113 115 rs2052428 Imputed C DOM 426 0.6505 0.2223 0.4208 1.006 −1.935 0.05303 0.06403 0.46479 0.45278 0.47358 39 85 56 43 147 56 rs2053230 Imputed C ADD 269 0.6927 0.629 0.2019 2.376 −0.584 0.5594 1 0.0223 0.01724 0.02614 0 4 112 0 8 145 rs2062448 Imputed T DOM 429 0.5357 0.2593 0.3223 0.8905 −2.407 0.01607 0.2895 0.1014 0.07377 0.12195 0 27 156 2 56 188 rs2063420 Imputed C REC 430 1.886 0.2499 1.156 3.079 2.54 0.01109 0.6935 0.42791 0.46721 0.39879 45 81 57 36 125 86 rs2063591 Imputed C ADD 429 0.7822 0.144 0.5899 1.037 −1.705 0.08815 0.4321 0.4359 0.40164 0.46138 32 83 68 45 137 64 rs2063591 Imputed C DOM 429 0.6108 0.2122 0.403 0.9258 −2.324 0.02015 0.4321 0.4359 0.40164 0.46138 32 83 68 45 137 64 rs208026 Genotyped A DOM 431 1.516 0.1978 1.029 2.233 2.102 0.03554 0.295 0.24362 0.27989 0.2166 12 79 93 9 89 149 rs208029 Imputed T DOM 426 1.45 0.2007 0.9788 2.15 1.853 0.06389 0.4837 0.223 0.25138 0.20204 9 73 99 9 81 155 rs208757 Imputed G DOM 425 1.473 0.2014 0.9925 2.186 1.923 0.05453 1 0.22235 0.24862 0.20287 9 72 100 12 75 157 rs2095586 Imputed A DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs2095606 Imputed A DOM 424 0.6502 0.2018 0.4378 0.9657 −2.133 0.03293 0.209 0.36439 0.33607 0.38589 22 79 82 28 130 83 rs2102374 Imputed A ADD 431 0.7364 0.156 0.5424 0.9998 −1.961 0.04987 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs2102374 Imputed A DOM 431 0.6065 0.198 0.4114 0.894 −2.526 0.01155 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs2108426 Imputed C DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs2110664 Imputed A DOM 421 1.806 0.2004 1.219 2.675 2.95 0.00318 0.4046 0.28622 0.33989 0.24691 20 81 77 18 84 141 rs2132242 Imputed A ADD 431 0.6841 0.1503 0.5096 0.9184 −2.527 0.01152 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs2132242 Imputed A DOM 431 0.62 0.207 0.4133 0.9302 −2.31 0.0209 0.132 0.40023 0.35054 0.43725 20 89 75 41 134 72 rs2158958 Imputed A DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs2158961 Imputed G DOM 431 0.7035 0.1964 0.4787 1.034 −1.791 0.07336 0.8246 0.31903 0.29348 0.33806 19 70 95 26 115 106 rs2163046 Imputed A DOM 430 1.511 0.1971 1.027 2.224 2.095 0.0362 0.03049 0.27791 0.31694 0.24899 14 88 81 10 103 134 rs2180286 Imputed G DOM 431 0.7195 0.2291 0.4592 1.127 −1.437 0.1507 0.3351 0.51856 0.47826 0.54858 42 92 50 79 113 55 rs2180684 Imputed A DOM 427 1.612 0.2668 0.9556 2.719 1.79 0.07349 0.525 0.08431 0.10165 0.07143 1 35 146 3 29 213 rs2188079 Imputed C ADD 430 1.535 0.1452 1.154 2.04 2.948 0.00319 0.6891 0.40116 0.45902 0.3583 36 96 51 31 115 101 rs2188079 Imputed C GEN 430 8.853 0.01196 0.6891 0.40116 0.45902 0.3583 36 96 51 31 115 101 rs2190598 Imputed T DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs2190600 Imputed A DOM 423 0.6884 0.1986 0.4665 1.016 −1.88 0.0601 0.8235 0.32151 0.29444 0.34156 19 68 93 26 114 103 rs2224184 Genotyped T DOM 431 0.7175 0.2276 0.4593 1.121 −1.458 0.1447 0.289 0.51508 0.47554 0.54453 42 91 51 78 113 56 rs2247066 Imputed A DOM 431 0.6603 0.1967 0.4491 0.9708 −2.11 0.03482 0.6452 0.29698 0.26902 0.31781 18 63 103 22 113 112 rs2248236 Imputed C ADD 430 0.7444 0.1691 0.5344 1.037 −1.746 0.08088 0.8894 0.22326 0.19565 0.2439 10 52 122 12 96 138 rs2248236 Imputed C DOM 430 0.6416 0.2031 0.431 0.9552 −2.186 0.02885 0.8894 0.22326 0.19565 0.2439 10 52 122 12 96 138 rs2265733 Imputed C ADD 431 0.7364 0.156 0.5424 0.9998 −1.961 0.04987 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs2265733 Imputed C DOM 431 0.6065 0.198 0.4114 0.894 −2.526 0.01155 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs2270584 Imputed A ADD 431 0.6858 0.1487 0.5125 0.9178 −2.537 0.01119 0.3138 0.39559 0.34511 0.4332 21 85 78 41 132 74 rs2270584 Imputed A DOM 431 0.6021 0.2055 0.4025 0.9008 −2.468 0.01358 0.3138 0.39559 0.34511 0.4332 21 85 78 41 132 74 rs2270586 Imputed A ADD 431 0.6858 0.1487 0.5125 0.9178 −2.537 0.01119 0.3138 0.39559 0.34511 0.4332 21 85 78 41 132 74 rs2270586 Imputed A DOM 431 0.6021 0.2055 0.4025 0.9008 −2.468 0.01358 0.3138 0.39559 0.34511 0.4332 21 85 78 41 132 74 rs229775 Imputed A REC 431 0.5915 0.3332 0.3078 1.136 −1.576 0.115 0.519 0.33875 0.33152 0.34413 15 92 77 31 108 108 rs229815 Imputed T REC 428 0.5493 0.3402 0.282 1.07 −1.761 0.07822 0.4505 0.33762 0.32787 0.3449 14 92 77 31 107 107 rs229829 Imputed C REC 431 0.6223 0.2965 0.3481 1.113 −1.6 0.1096 0.7583 0.37587 0.36141 0.38664 20 93 71 39 113 95 rs229831 Imputed A REC 431 0.646 0.3469 0.3273 1.275 −1.26 0.2077 0.8231 0.31439 0.30978 0.31781 14 86 84 27 103 117 rs2317057 Imputed T ADD 363 0.7197 0.1827 0.5031 1.029 −1.801 0.07173 0.03577 0.20523 0.17208 0.22967 4 45 105 18 60 131 rs2322100 Genotyped T REC 431 2.767 0.3609 1.364 5.612 2.82 0.0048 0.4748 0.28074 0.31522 0.25506 24 68 92 13 100 134 rs2322101 Imputed A REC 429 2.779 0.3611 1.369 5.639 2.83 0.00465 0.4732 0.28089 0.31694 0.25407 24 68 91 13 99 134 rs2327929 Imputed G REC 431 1.493 0.244 0.9255 2.408 1.642 0.1005 0.5607 0.45244 0.46467 0.44332 43 85 56 42 135 70 rs2332844 Imputed A ADD 240 1.78 0.4323 0.7629 4.154 1.334 0.1823 1 0.94167 0.95909 0.92692 101 9 0 111 19 0 rs2332844 Imputed A REC 240 1.78 0.4323 0.7629 4.154 1.334 0.1823 1 0.94167 0.95909 0.92692 101 9 0 111 19 0 rs2349170 Imputed G DOM 430 1.327 0.204 0.8895 1.979 1.386 0.1657 0.1032 0.20581 0.22011 0.19512 9 63 112 15 66 165 rs2356722 Imputed G DOM 431 0.6675 0.1966 0.4541 0.9812 −2.057 0.03972 0.9089 0.30162 0.27446 0.32186 18 65 101 22 115 110 rs2364956 Imputed T ADD 423 1.693 0.1737 1.204 2.379 3.031 0.00244 0.00724 0.17849 0.22652 0.14256 10 62 109 12 45 185 rs2373793 Imputed G ADD 430 1.58 0.174 1.124 2.223 2.629 0.00855 0.7647 0.2 0.23913 0.17073 8 72 104 10 64 172 rs2373793 Imputed G DOM 430 1.878 0.2064 1.253 2.815 3.055 0.00225 0.7647 0.2 0.23913 0.17073 8 72 104 10 64 172 rs238252 Imputed G ADD 427 1.531 0.1916 1.052 2.229 2.223 0.02622 0.8581 0.15925 0.19126 0.13525 6 58 119 4 58 182 rs238252 Imputed G DOM 427 1.593 0.2148 1.046 2.427 2.169 0.03007 0.8581 0.15925 0.19126 0.13525 6 58 119 4 58 182 rs2383903 Imputed G DOM 430 0.6499 0.1976 0.4413 0.9572 −2.181 0.02915 0.5438 0.27209 0.23497 0.2996 10 66 107 19 110 118 rs2387945 Imputed G DOM 431 1.335 0.2271 0.8555 2.084 1.273 0.203 0.674 0.12993 0.1413 0.12146 2 48 134 6 48 193 rs2389863 Imputed A DOM 426 0.6341 0.2035 0.4255 0.9449 −2.238 0.0252 0.8901 0.22535 0.19672 0.24691 10 52 121 12 96 135 rs2389866 Imputed C DOM 431 0.6359 0.2028 0.4273 0.9464 −2.232 0.02564 0.8902 0.2239 0.19565 0.24494 10 52 122 12 97 138 rs2389869 Imputed C DOM 431 0.6359 0.2028 0.4273 0.9464 −2.232 0.02564 0.8902 0.2239 0.19565 0.24494 10 52 122 12 97 138 rs2389870 Genotyped C DOM 431 0.7988 0.2067 0.5327 1.198 −1.087 0.2772 0.7543 0.19026 0.17663 0.2004 6 53 125 8 83 156 rs2418494 Imputed G ADD 423 0.7065 0.1402 0.5367 0.93 −2.477 0.01323 0.6254 0.53073 0.47778 0.56996 46 80 54 76 125 42 rs2418494 Imputed G GEN 423 8.762 0.01252 0.6254 0.53073 0.47778 0.56996 46 80 54 76 125 42 rs2418541 Imputed A DOM 431 0.7035 0.1964 0.4787 1.034 −1.791 0.07336 0.7398 0.32019 0.2962 0.33806 20 69 95 26 115 106 rs2418542 Imputed A DOM 431 0.7035 0.1964 0.4787 1.034 −1.791 0.07336 0.7398 0.32019 0.2962 0.33806 20 69 95 26 115 106 rs2423556 Imputed C DOM 431 0.7195 0.2291 0.4592 1.127 −1.437 0.1507 0.3351 0.51856 0.47826 0.54858 42 92 50 79 113 55 rs2437688 Imputed C ADD 431 1.486 0.2416 0.9251 2.385 1.638 0.1014 0.5494 0.08701 0.10598 0.07287 3 33 148 1 34 212 rs2456809 Imputed G DOM 426 0.6547 0.1977 0.4444 0.9645 −2.143 0.03215 0.7299 0.30047 0.27473 0.31967 19 62 101 21 114 109 rs2456811 Imputed T ADD 431 0.7364 0.156 0.5424 0.9998 −1.961 0.04987 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs2456811 Imputed T DOM 431 0.6065 0.198 0.4114 0.894 −2.526 0.01155 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs2476976 Imputed C DOM 429 1.409 0.1971 0.9578 2.074 1.741 0.08162 0.293 0.29138 0.31522 0.27347 18 80 86 23 88 134 rs2484911 Imputed A DOM 431 1.477 0.1971 1.004 2.173 1.979 0.04785 0.2786 0.27494 0.29891 0.25709 15 80 89 22 83 142 rs2488557 Imputed C DOM 428 0.6282 0.2326 0.3982 0.991 −1.999 0.04561 0.3091 0.13902 0.10656 0.16327 2 35 146 9 62 174 rs250162 Imputed C ADD 425 0.5822 0.1715 0.416 0.8149 −3.153 0.00162 0.5202 0.25176 0.1989 0.29098 8 56 117 16 110 118 rs250162 Imputed C DOM 425 0.5055 0.2024 0.3399 0.7517 −3.37 0.00075 0.5202 0.25176 0.1989 0.29098 8 56 117 16 110 118 rs2560708 Imputed T ADD 427 0.5918 0.2008 0.3992 0.8772 −2.612 0.00899 0.5877 0.15808 0.12088 0.18571 2 40 140 10 71 164 rs2617841 Imputed G DOM 397 0.5505 0.2134 0.3623 0.8365 −2.797 0.00516 0.773 0.22418 0.18235 0.25551 8 46 116 13 90 124 rs2622499 Imputed G DOM 431 0.6359 0.2028 0.4273 0.9464 −2.232 0.02564 0.8902 0.2239 0.19565 0.24494 10 52 122 12 97 138 rs264129 Imputed T DOM 414 0.7088 0.2008 0.4781 1.051 −1.714 0.08655 0.9112 0.32729 0.30226 0.34599 19 69 89 26 112 99 rs2642936 Imputed T ADD 427 1.703 0.1807 1.195 2.427 2.947 0.00321 1 0.18735 0.23077 0.1551 10 64 108 5 66 174 rs2660633 Imputed A DOM 428 0.6523 0.1975 0.443 0.9607 −2.163 0.03053 0.8167 0.29673 0.26923 0.31707 18 62 102 21 114 111 rs2660634 Imputed C DOM 428 0.6523 0.1975 0.443 0.9607 −2.163 0.03053 0.8167 0.29673 0.26923 0.31707 18 62 102 21 114 111 rs2660648 Imputed A ADD 431 0.7364 0.156 0.5424 0.9998 −1.961 0.04987 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs2660648 Imputed A DOM 431 0.6065 0.198 0.4114 0.894 −2.526 0.01155 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs2681505 Imputed T ADD 431 0.6724 0.1684 0.4834 0.9355 −2.356 0.01848 0.6967 0.24594 0.20652 0.2753 7 62 115 17 102 128 rs277411 Imputed G DOM 430 0.2825 0.5064 0.1047 0.7621 −2.496 0.01254 0.01107 0.03488 0.01902 0.04675 2 3 179 1 21 224 rs2832634 Imputed G ADD 430 2.272 0.3513 1.141 4.523 2.335 0.01952 0.5344 0.04186 0.06011 0.02834 1 20 162 0 14 233 rs2832637 Imputed T ADD 430 2.272 0.3513 1.141 4.523 2.335 0.01952 0.5344 0.04186 0.06011 0.02834 1 20 162 0 14 233 rs2843167 Imputed A DOM 430 0.6655 0.1968 0.4525 0.9788 −2.069 0.03855 0.6437 0.29651 0.27174 0.31504 19 62 103 21 113 112 rs2876227 Imputed C ADD 420 1.382 0.142 1.046 1.825 2.277 0.02278 0.11 0.35595 0.39779 0.32427 30 84 67 31 93 115 rs2876227 Imputed C GEN 420 5.885 0.05274 0.11 0.35595 0.39779 0.32427 30 84 67 31 93 115 rs2882097 Imputed A DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs2909862 Imputed G DOM 381 1.471 0.2415 0.9162 2.361 1.597 0.1102 0.06435 0.46457 0.48171 0.45161 30 98 36 43 110 64 rs3001945 Imputed T DOM 408 1.39 0.2492 0.8531 2.266 1.323 0.186 0.7949 0.10662 0.1185 0.09787 1 39 133 4 38 193 rs3011020 Imputed C DOM 431 1.335 0.2271 0.8555 2.084 1.273 0.203 0.674 0.12993 0.1413 0.12146 2 48 134 6 48 193 rs36071725 Genotyped C ADD 431 1.458 0.1473 1.093 1.946 2.562 0.01039 0.9158 0.35035 0.39674 0.31579 26 94 64 26 104 117 rs36071725 Genotyped C GEN 431 7.178 0.02762 0.9158 0.35035 0.39674 0.31579 26 94 64 26 104 117 rs373983 Imputed G DOM 424 1.332 0.2094 0.8836 2.008 1.369 0.171 1 0.41038 0.425 0.39959 29 95 56 42 111 91 rs3743794 Imputed G DOM 426 0.6969 0.2073 0.4642 1.046 −1.742 0.08148 0.1305 0.40258 0.38462 0.41598 28 84 70 33 137 74 rs3756154 Imputed C ADD 431 0.7399 0.1691 0.5312 1.031 −1.782 0.07475 0.8902 0.2239 0.19565 0.24494 10 52 122 12 97 138 rs3756154 Imputed C DOM 431 0.6359 0.2028 0.4273 0.9464 −2.232 0.02564 0.8902 0.2239 0.19565 0.24494 10 52 122 12 97 138 rs3775850 Imputed A DOM 431 0.7804 0.2073 0.5199 1.172 −1.196 0.2317 0.6351 0.18794 0.1712 0.2004 5 53 126 8 83 156 rs3775851 Imputed C DOM 431 0.7804 0.2073 0.5199 1.172 −1.196 0.2317 0.6351 0.18794 0.1712 0.2004 5 53 126 8 83 156 rs3793044 Imputed C ADD 431 1.892 0.308 1.035 3.461 2.071 0.0384 1 0.05452 0.07337 0.04049 0 27 157 1 18 228 rs3793044 Imputed C DOM 431 2.057 0.3182 1.102 3.838 2.266 0.02342 1 0.05452 0.07337 0.04049 0 27 157 1 18 228 rs3793053 Imputed C DOM 425 2.254 0.3145 1.217 4.175 2.583 0.00979 0.1831 0.06 0.08287 0.04303 1 28 152 2 17 225 rs3796246 Imputed G DOM 431 0.4542 0.2717 0.2667 0.7737 −2.904 0.00368 0.7838 0.09629 0.0625 0.12146 0 23 161 3 54 190 rs3806003 Imputed A ADD 431 1.892 0.308 1.035 3.461 2.071 0.0384 1 0.05452 0.07337 0.04049 0 27 157 1 18 228 rs3806003 Imputed A DOM 431 2.057 0.3182 1.102 3.838 2.266 0.02342 1 0.05452 0.07337 0.04049 0 27 157 1 18 228 rs3806004 Imputed T DOM 431 2.24 0.3143 1.21 4.147 2.566 0.0103 0.1777 0.05916 0.08152 0.04251 1 28 155 2 17 228 rs3806010 Imputed T DOM 431 2.24 0.3143 1.21 4.147 2.566 0.0103 0.1777 0.05916 0.08152 0.04251 1 28 155 2 17 228 rs3806014 Imputed T DOM 431 2.24 0.3143 1.21 4.147 2.566 0.0103 0.1777 0.05916 0.08152 0.04251 1 28 155 2 17 228 rs3806015 Imputed A DOM 431 2.24 0.3143 1.21 4.147 2.566 0.0103 0.1777 0.05916 0.08152 0.04251 1 28 155 2 17 228 rs3806018 Imputed A DOM 431 2.24 0.3143 1.21 4.147 2.566 0.0103 0.1777 0.05916 0.08152 0.04251 1 28 155 2 17 228 rs3806019 Imputed A DOM 431 2.24 0.3143 1.21 4.147 2.566 0.0103 0.1777 0.05916 0.08152 0.04251 1 28 155 2 17 228 rs3806024 Imputed T DOM 425 2.254 0.3145 1.217 4.175 2.583 0.00979 0.1831 0.06 0.08287 0.04303 1 28 152 2 17 225 rs3915080 Imputed A GEN 426 6.343 0.04195 0.03262 0.34859 0.39946 0.30992 34 79 71 28 94 120 rs3942254 Imputed T ADD 423 0.6915 0.1524 0.513 0.9322 −2.421 0.01549 0.07006 0.4078 0.35955 0.44286 20 88 70 41 135 69 rs3942254 Imputed T DOM 423 0.6256 0.2108 0.4139 0.9456 −2.225 0.02605 0.07006 0.4078 0.35955 0.44286 20 88 70 41 135 69 rs3945085 Imputed A DOM 431 1.52 0.1971 1.033 2.237 2.125 0.03357 0.4125 0.29002 0.32065 0.26721 18 82 84 22 88 137 rs3976737 Imputed G ADD 430 0.6593 0.2103 0.4366 0.9956 −1.981 0.0476 0.2881 0.1314 0.10383 0.15182 1 36 146 9 57 181 rs399485 Imputed A DOM 431 1.467 0.1973 0.9965 2.159 1.942 0.05212 0.6505 0.30626 0.33424 0.28543 17 89 78 21 99 127 rs4029119 Imputed G ADD 429 0.361 0.577 0.1165 1.118 −1.766 0.0774 1 0.02098 0.01087 0.02857 0 4 180 0 14 231 rs4029119 Imputed G DOM 429 0.361 0.577 0.1165 1.118 −1.766 0.0774 1 0.02098 0.01087 0.02857 0 4 180 0 14 231 rs4076201 Imputed G GEN 430 6.108 0.04718 0.893 0.23372 0.25272 0.21951 16 61 107 8 92 146 rs4076201 Imputed G REC 430 2.964 0.4471 1.234 7.119 2.43 0.01509 0.893 0.23372 0.25272 0.21951 16 61 107 8 92 146 rs41395945 Imputed G ADD 430 2.272 0.3513 1.141 4.523 2.335 0.01952 0.5344 0.04186 0.06011 0.02834 1 20 162 0 14 233 rs41395945 Imputed G DOM 430 2.245 0.362 1.104 4.564 2.234 0.02549 0.5344 0.04186 0.06011 0.02834 1 20 162 0 14 233 rs4146972 Genotyped T DOM 431 1.557 0.2271 0.9976 2.43 1.949 0.05125 0.2068 0.13341 0.16033 0.11336 6 47 131 5 46 196 rs4238087 Imputed G DOM 425 0.5314 0.2341 0.3358 0.8408 −2.7 0.00692 0.1486 0.13765 0.1 0.16531 1 34 145 3 75 167 rs4251569 Imputed T ADD 425 0.5471 0.2243 0.3525 0.8491 −2.689 0.00716 0.1486 0.13765 0.1 0.16531 1 34 145 3 75 167 rs4251569 Imputed T DOM 425 0.5314 0.2341 0.3358 0.8408 −2.7 0.00692 0.1486 0.13765 0.1 0.16531 1 34 145 3 75 167 rs4273613 Imputed T ADD 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs4273613 Imputed T DOM 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs4291049 Imputed T REC 428 0.5862 0.2628 0.3502 0.9812 −2.032 0.04213 0.3793 0.44509 0.42896 0.45714 26 105 52 54 116 75 rs4315598 Imputed T ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs4315598 Imputed T GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs4315598 Imputed T REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs4321395 Imputed A DOM 400 0.5278 0.2223 0.3414 0.816 −2.875 0.00404 0.7625 0.44625 0.39458 0.48291 28 75 63 50 126 58 rs4321596 Genotyped T REC 431 3.01 0.5138 1.099 8.238 2.145 0.03199 0.6475 0.19606 0.21196 0.18421 12 54 118 6 79 162 rs4324417 Imputed T DOM 431 1.541 0.2104 1.02 2.328 2.055 0.03989 0.7663 0.41763 0.44022 0.40081 32 98 54 45 108 94 rs4328619 Genotyped G DOM 431 0.6446 0.2226 0.4167 0.9973 −1.972 0.04857 0.8472 0.49536 0.44837 0.53036 37 91 56 70 122 55 rs4338909 Imputed T ADD 431 1.42 0.1425 1.074 1.878 2.462 0.01381 0.9195 0.39211 0.44022 0.35628 36 90 58 31 114 102 rs4370878 Imputed G DOM 431 1.497 0.197 1.017 2.202 2.046 0.04075 0.4153 0.29118 0.32065 0.26923 18 82 84 22 89 136 rs4379434 Genotyped T DOM 431 1.603 0.203 1.077 2.386 2.323 0.02015 0.6081 0.37471 0.4375 0.32794 38 85 61 25 112 110 rs4416407 Imputed T DOM 429 1.502 0.2225 0.9712 2.324 1.829 0.06743 0.06631 0.49068 0.51913 0.46951 50 90 43 63 105 78 rs4417899 Imputed C REC 429 0.6657 0.2225 0.4304 1.03 −1.829 0.06743 0.06631 0.50932 0.48087 0.53049 43 90 50 78 105 63 rs4442732 Imputed A ADD 335 0.7543 0.1867 0.5231 1.088 −1.511 0.1309 0.4915 0.27313 0.24632 0.29146 8 51 77 14 88 97 rs4444612 Imputed G ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs4444612 Imputed G GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs4444612 Imputed G REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs4450660 Imputed C DOM 430 1.776 0.2015 1.196 2.636 2.849 0.00438 0.5652 0.21279 0.25137 0.18421 7 78 98 10 71 166 rs4509702 Imputed C DOM 431 1.497 0.197 1.017 2.202 2.046 0.04075 0.4153 0.29118 0.32065 0.26923 18 82 84 22 89 136 rs4526920 Imputed G GEN 431 7.984 0.01846 0.5855 0.32831 0.3587 0.30567 30 72 82 19 113 115 rs4533145 Imputed T DOM 430 0.6617 0.2453 0.4092 1.07 −1.683 0.09231 1 0.11395 0.0929 0.12955 2 30 151 3 58 186 rs4557006 Imputed A DOM 395 0.5409 0.225 0.348 0.8407 −2.731 0.00631 0.6853 0.45063 0.40123 0.48498 28 74 60 50 126 57 rs4570530 Imputed C DOM 431 1.497 0.197 1.017 2.202 2.046 0.04075 0.4153 0.29118 0.32065 0.26923 18 82 84 22 89 136 rs4615971 Imputed C DOM 429 1.474 0.1973 1.001 2.17 1.965 0.04937 0.3529 0.29371 0.32065 0.27347 18 82 84 23 88 134 rs4628119 Imputed A DOM 431 0.5304 0.202 0.357 0.7881 −3.139 0.0017 0.1465 0.24014 0.20109 0.26923 9 56 119 10 113 124 rs4664443 Imputed G ADD 431 0.6931 0.1457 0.521 0.9221 −2.517 0.01184 0.6898 0.40371 0.35598 0.43927 22 87 75 46 125 76 rs4688259 Imputed T DOM 429 1.502 0.2225 0.9712 2.324 1.829 0.06743 0.06631 0.49068 0.51913 0.46951 50 90 43 63 105 78 rs4688632 Imputed G REC 426 0.6718 0.2217 0.435 1.038 −1.794 0.07285 0.3819 0.52465 0.49727 0.54527 44 94 45 78 109 56 rs4695284 Imputed A ADD 231 1.566 0.2722 0.9182 2.669 1.647 0.09965 0.7943 0.14719 0.17935 0.1259 3 27 62 1 33 105 rs4700302 Imputed A ADD 368 0.5418 0.2966 0.303 0.9689 −2.067 0.03877 1 0.08152 0.05806 0.09859 0 18 137 2 38 173 rs4702720 Imputed A ADD 363 0.7075 0.1961 0.4817 1.039 −1.765 0.07759 0.7438 0.19835 0.16774 0.22115 3 46 106 10 72 126 rs4702720 Imputed A DOM 363 0.7149 0.2239 0.461 1.109 −1.499 0.1339 0.7438 0.19835 0.16774 0.22115 3 46 106 10 72 126 rs4711091 Genotyped G GEN 431 3.583 0.1667 0.63 0.47564 0.51359 0.44737 48 93 43 52 117 78 rs4714484 Imputed A ADD 431 0.5609 0.1882 0.3879 0.8112 −3.071 0.00213 0.1396 0.17749 0.12772 0.21457 6 35 143 12 82 153 rs4736802 Imputed G DOM 430 1.614 0.2031 1.084 2.404 2.357 0.01841 0.6067 0.37442 0.4375 0.32724 38 85 61 25 111 110 rs4760785 Imputed A ADD 429 0.7714 0.144 0.5817 1.023 −1.803 0.07146 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs4760785 Imputed A DOM 429 0.5986 0.2106 0.3961 0.9045 −2.436 0.01484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs4760785 Imputed A GEN 429 6.21 0.04484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs4760894 Imputed T ADD 429 0.7714 0.144 0.5817 1.023 −1.803 0.07146 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs4760894 Imputed T DOM 429 0.5986 0.2106 0.3961 0.9045 −2.436 0.01484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs4760894 Imputed T GEN 429 6.21 0.04484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs4760895 Imputed A ADD 429 0.7714 0.144 0.5817 1.023 −1.803 0.07146 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs4760895 Imputed A DOM 429 0.5986 0.2106 0.3961 0.8045 −2.436 0.01484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs4760895 Imputed A GEN 429 6.21 0.04484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs4764738 Imputed A ADD 425 1.555 0.1426 1.176 2.056 3.095 0.00197 1 0.49412 0.55801 0.44672 57 88 36 47 124 73 rs4764738 Imputed A GEN 425 9.814 0.00739 1 0.49412 0.55801 0.44672 57 88 36 47 124 73 rs4764974 Imputed T ADD 430 1.512 0.1414 1.146 1.995 2.923 0.00347 1 0.49186 0.55163 0.44715 57 89 38 47 126 73 rs4764974 Imputed T GEN 430 8.948 0.0114 1 0.49186 0.55163 0.44715 57 89 38 47 126 73 rs4798366 Imputed G REC 426 2.304 0.315 1.243 4.271 2.65 0.00806 0.8267 0.33099 0.36264 0.30738 29 74 79 19 112 113 rs483159 Imputed T DOM 418 1.412 0.2046 0.9455 2.108 1.686 0.09181 0.6559 0.20694 0.23034 0.18958 7 68 103 9 73 158 rs4836502 Imputed T DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs4836507 Imputed C DOM 423 0.6884 0.1986 0.4665 1.016 −1.88 0.0601 0.8235 0.32151 0.29444 0.34156 19 68 93 26 114 103 rs4836744 Imputed A ADD 429 0.7704 0.1539 0.5698 1.042 −1.694 0.09021 0.1943 0.33566 0.30435 0.35918 17 78 89 25 126 94 rs4836744 Imputed A DOM 429 0.6637 0.1983 0.4499 0.979 −2.067 0.03872 0.1943 0.33566 0.30435 0.35918 17 78 89 25 126 94 rs4848944 Genotyped C REC 431 0.464 0.245 0.287 0.75 −3.134 0.00172 0.6299 0.48028 0.42935 0.51822 30 98 56 72 112 63 rs4851529 Imputed A DOM 431 0.5663 0.2029 0.3805 0.8429 −2.802 0.00507 0.5411 0.38399 0.35326 0.40688 28 74 82 32 137 78 rs4851531 Imputed T DOM 430 0.5588 0.2033 0.3751 0.8325 −2.862 0.00421 0.4774 0.38488 0.35326 0.40854 28 74 82 32 137 77 rs4858046 Genotyped T GEN 431 6.792 0.0335 0.0334 0.34687 0.39946 0.30769 34 79 71 28 96 123 rs4878214 Imputed A ADD 343 0.7413 0.1824 0.5185 1.06 −1.641 0.1007 0.6774 0.26531 0.23179 0.29167 8 54 89 14 84 94 rs4880803 Imputed A ADD 421 0.7588 0.1519 0.5634 1.022 −1.818 0.06914 0.9124 0.33017 0.29558 0.35625 13 81 87 32 107 101 rs489441 Imputed G ADD 408 1.6 0.1627 1.163 2.2 2.888 0.00387 0.2387 0.29779 0.35174 0.25847 19 83 70 12 98 126 rs489441 Imputed G DOM 408 1.651 0.2035 1.108 2.46 2.463 0.01378 0.2387 0.29779 0.35174 0.25847 19 83 70 12 98 126 rs4896568 Imputed T DOM 430 0.5426 0.2032 0.3643 0.8081 −3.008 0.00263 0.2215 0.2314 0.19022 0.2622 7 56 121 11 107 128 rs4938851 Imputed T DOM 431 1.301 0.2004 0.8785 1.927 1.313 0.1891 0.6787 0.2239 0.24728 0.20648 11 69 104 12 78 157 rs4964416 Imputed C DOM 428 0.6799 0.2267 0.436 1.06 −1.702 0.08872 0.1753 0.48715 0.46961 0.5 41 88 52 53 141 53 rs5756669 Imputed C DOM 431 1.541 0.2104 1.02 2.328 2.055 0.03989 0.7663 0.41763 0.44022 0.40081 32 98 54 45 108 94 rs6033138 Imputed C ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6033138 Imputed C GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6033138 Imputed C REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040619 Imputed C ADD 427 1.488 0.1435 1.123 1.972 2.771 0.00559 0.202 0.34895 0.39946 0.3107 31 85 68 27 97 119 rs6040619 Imputed C GEN 427 7.811 0.02013 0.202 0.34895 0.39946 0.3107 31 85 68 27 97 119 rs6040619 Imputed C REC 427 1.688 0.2858 0.964 2.956 1.832 0.06702 0.202 0.34895 0.39946 0.3107 31 85 68 27 97 119 rs6040625 Imputed T ADD 425 1.479 0.1442 1.115 1.962 2.714 0.00665 0.2386 0.34706 0.39617 0.30992 30 85 68 27 96 119 rs6040625 Imputed T GEN 425 7.591 0.02248 0.2386 0.34706 0.39617 0.30992 30 85 68 27 96 119 rs6040625 Imputed T REC 425 1.634 0.2879 0.9294 2.873 1.706 0.08806 0.2386 0.34706 0.39617 0.30992 30 85 68 27 96 119 rs6040630 Imputed A ADD 431 1.42 0.1417 1.076 1.875 2.476 0.01327 0.1692 0.35151 0.39674 0.31781 30 86 68 30 97 120 rs6040630 Imputed A GEN 431 6.71 0.03491 0.1692 0.35151 0.39674 0.31781 30 86 68 30 97 120 rs6040630 Imputed A REC 431 1.462 0.2807 0.8433 2.534 1.353 0.1762 0.1692 0.35151 0.39674 0.31781 30 86 68 30 97 120 rs6040633 Imputed A ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040633 Imputed A GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040633 Imputed A REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040634 Imputed T ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040634 Imputed T GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040634 Imputed T REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040636 Imputed T ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040636 Imputed T GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040636 Imputed T REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040638 Imputed C ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040638 Imputed C GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040638 Imputed C REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040644 Imputed A ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040644 Imputed A GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040644 Imputed A REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6040667 Imputed T ADD 427 1.391 0.1412 1.055 1.835 2.338 0.0194 0.09068 0.35246 0.3956 0.32041 30 84 68 31 95 119 rs6040667 Imputed T GEN 427 6.078 0.04788 0.09068 0.35246 0.3956 0.32041 30 84 68 31 95 119 rs6040667 Imputed T REC 427 1.416 0.2791 0.8195 2.447 1.247 0.2125 0.09068 0.35246 0.3956 0.32041 30 84 68 31 95 119 rs6040668 Imputed C ADD 422 1.386 0.1419 1.049 1.83 2.3 0.02147 0.1109 0.35545 0.39779 0.32365 30 84 67 31 94 116 rs6040668 Imputed C GEN 422 5.936 0.05141 0.1109 0.35545 0.39779 0.32365 30 84 67 31 94 116 rs6040668 Imputed C REC 422 1.401 0.2794 0.8101 2.422 1.206 0.2277 0.1109 0.35545 0.39779 0.32365 30 84 67 31 94 116 rs6043066 Genotyped G DOM 431 1.208 0.1979 0.8196 1.781 0.955 0.3397 0.8951 0.23898 0.24185 0.23684 7 75 102 18 81 148 rs6048146 Imputed G DOM 431 3.484 0.6015 1.072 11.33 2.075 0.03796 1 0.01624 0.02717 0.0081 0 10 174 0 4 243 rs6082725 Genotyped T DOM 431 3.484 0.6015 1.072 11.33 2.075 0.03796 1 0.01624 0.02717 0.0081 0 10 174 0 4 243 rs6131206 Imputed C ADD 429 1.424 0.1456 1.07 1.894 2.425 0.01529 0.1797 0.31585 0.35989 0.2834 25 81 76 24 92 131 rs6131208 Imputed T ADD 429 1.398 0.1412 1.06 1.843 2.371 0.01776 0.1119 0.35198 0.3956 0.31984 30 84 68 31 96 120 rs6131208 Imputed T GEN 429 6.201 0.04504 0.1119 0.35198 0.3956 0.31984 30 84 68 31 96 120 rs6131208 Imputed T REC 429 1.431 0.2791 0.828 2.472 1.284 0.1993 0.1119 0.35198 0.3956 0.31984 30 84 68 31 96 120 rs6134243 Imputed C ADD 431 1.407 0.1412 1.067 1.855 2.418 0.01561 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6134243 Imputed C GEN 431 6.605 0.0368 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6134243 Imputed C REC 431 1.414 0.279 0.8186 2.444 1.243 0.214 0.1149 0.35267 0.39674 0.31984 30 86 68 31 96 120 rs6136020 Imputed A DOM 431 0.7169 0.227 0.4595 1.119 −1.466 0.1426 0.2387 0.14385 0.12228 0.15992 4 37 143 8 63 176 rs613799 Imputed C DOM 414 1.45 0.2012 0.9772 2.15 1.845 0.06502 0.3305 0.2814 0.30398 0.26471 15 77 84 22 82 134 rs644041 Imputed G ADD 401 1.555 0.164 1.127 2.144 2.69 0.00715 0.2323 0.29676 0.34706 0.25974 18 82 70 12 96 123 rs644041 Imputed G DOM 401 1.611 0.2049 1.078 2.407 2.327 0.01999 0.2323 0.29676 0.34706 0.25974 18 82 70 12 96 123 rs647645 Imputed C ADD 430 0.7227 0.1429 0.5462 0.9563 −2.273 0.02304 0.5622 0.48372 0.44022 0.51626 29 104 51 68 118 60 rs647645 Imputed C GEN 430 8.278 0.01594 0.5622 0.48372 0.44022 0.51626 29 104 51 68 118 60 rs647645 Imputed C REC 430 0.4895 0.2484 0.3008 0.7965 −2.876 0.00403 0.5622 0.48372 0.44022 0.51626 29 104 51 68 118 60 rs6495554 Imputed C GEN 431 6.084 0.04773 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs6495554 Imputed C REC 431 3.183 0.4709 1.265 8.011 2.459 0.01395 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs6495555 Imputed C GEN 431 6.084 0.04773 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs6495555 Imputed C REC 431 3.183 0.4709 1.265 8.011 2.459 0.01395 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs6544728 Imputed T DOM 429 1.888 0.2031 1.268 2.811 3.128 0.00176 0.7694 0.20746 0.25 0.17611 7 77 98 10 67 170 rs6550705 Imputed C ADD 430 1.45 0.1393 1.104 1.906 2.67 0.00759 0.02491 0.34535 0.39946 0.30488 34 79 71 28 94 124 rs6550705 Imputed C GEN 430 7.13 0.0283 0.02491 0.34535 0.39946 0.30488 34 79 71 28 94 124 rs6550707 Imputed T GEN 430 6.869 0.03224 0.03283 0.34651 0.39946 0.30691 34 79 71 28 95 123 rs658108 Imputed A DOM 431 1.477 0.1971 1.004 2.173 1.979 0.04785 0.2786 0.27494 0.29891 0.25709 15 80 89 22 83 142 rs6593441 Imputed A DOM 404 1.885 0.2414 1.175 3.026 2.627 0.00862 0.04333 0.12624 0.16667 0.09471 8 43 126 3 37 187 rs668732 Imputed A DOM 431 1.56 0.2218 1.01 2.409 2.004 0.04506 0.9229 0.46752 0.49728 0.44534 42 99 43 53 114 80 rs671041 Imputed A DOM 431 1.507 0.1971 1.024 2.217 2.08 0.03752 0.3349 0.2761 0.30163 0.25709 15 81 88 22 83 142 rs6719700 Imputed A ADD 412 1.583 0.1792 1.114 2.249 2.562 0.0104 0.00157 0.25243 0.29261 0.22246 10 83 83 4 97 135 rs6719700 Imputed A DOM 412 1.517 0.2015 1.022 2.252 2.07 0.03845 0.00157 0.25243 0.29261 0.22246 10 83 83 4 97 135 rs6722640 Imputed T DOM 431 0.5555 0.2033 0.373 0.8273 −2.892 0.00382 0.4151 0.38399 0.35326 0.40688 28 74 82 31 139 77 rs6743092 Imputed T ADD 431 1.365 0.1398 1.038 1.796 2.226 0.02603 0.9233 0.471 0.51359 0.43927 49 91 44 47 123 77 rs6743092 Imputed T GEN 431 4.984 0.08273 0.9233 0.471 0.51359 0.43927 49 91 44 47 123 77 rs6743092 Imputed T REC 431 1.555 0.2336 0.9841 2.458 1.891 0.05858 0.9233 0.471 0.51359 0.43927 49 91 44 47 123 77 rs6744759 Imputed G REC 424 1.89 0.3377 0.9751 3.664 1.885 0.0594 0.9086 0.30425 0.32597 0.28807 23 72 86 17 106 120 rs6746170 Imputed A DOM 425 1.805 0.2035 1.211 2.69 2.901 0.00372 0.7693 0.20941 0.24862 0.18033 7 76 98 10 68 166 rs6759922 Imputed A DOM 399 0.537 0.2229 0.3469 0.8311 −2.79 0.00527 0.7616 0.44737 0.39697 0.48291 28 75 62 50 126 58 rs6769864 Imputed T GEN 431 7.055 0.02938 0.02563 0.34571 0.39946 0.30567 34 79 71 28 95 124 rs6773932 Imputed C GEN 426 5.96 0.05078 0.03445 0.35563 0.40489 0.31818 34 81 69 30 94 118 rs6774353 Imputed A GEN 431 7.055 0.02938 0.02563 0.34571 0.39946 0.30567 34 79 71 28 95 124 rs6781670 Imputed C GEN 431 7.563 0.02279 0.04132 0.34107 0.39674 0.2996 33 80 71 27 94 126 rs6786431 Imputed A GEN 426 5.96 0.05078 0.03445 0.35563 0.40489 0.31818 34 81 69 30 94 118 rs6789091 Imputed T GEN 426 5.96 0.05078 0.03445 0.35563 0.40489 0.31818 34 81 69 30 94 118 rs6791296 Imputed T ADD 414 0.6404 0.2337 0.4051 1.012 −1.907 0.05647 0.6349 0.11836 0.09483 0.13542 2 29 143 2 61 177 rs6792662 Imputed G DOM 429 1.502 0.2225 0.9712 2.324 1.829 0.06743 0.06631 0.49068 0.51913 0.46951 50 90 43 63 105 78 rs6797574 Imputed G GEN 426 5.96 0.05078 0.03445 0.35563 0.40489 0.31818 34 81 69 30 94 118 rs6797882 Imputed G GEN 426 5.96 0.05078 0.03445 0.35563 0.40489 0.31818 34 81 69 30 94 118 rs6805139 Imputed G DOM 428 1.519 0.2225 0.9819 2.348 1.878 0.06041 0.2865 0.47897 0.51099 0.45528 47 92 43 57 110 79 rs6806043 Imputed C ADD 430 1.47 0.1394 1.118 1.931 2.761 0.00577 0.02491 0.34535 0.40164 0.30364 34 79 70 28 94 125 rs6806043 Imputed C GEN 430 7.621 0.02214 0.02491 0.34535 0.40164 0.30364 34 79 70 28 94 125 rs6850716 Imputed C GEN 431 4.671 0.09677 1 0.19838 0.21739 0.18421 12 56 116 5 81 161 rs6867153 Imputed A REC 428 0.5862 0.2628 0.3502 0.9812 −2.032 0.04213 0.3793 0.44509 0.42896 0.45714 26 105 52 54 116 75 rs687047 Imputed C ADD 431 0.7129 0.2248 0.4589 1.107 −1.506 0.1321 0.8081 0.11253 0.09511 0.12551 2 31 151 4 54 189 rs6871041 Imputed G DOM 425 0.6929 0.1978 0.4702 1.021 −1.855 0.06367 0.7349 0.30941 0.28177 0.32992 16 70 95 23 115 106 rs688358 Imputed A ADD 427 0.6788 0.2285 0.4338 1.062 −1.695 0.08999 0.6295 0.11124 0.09116 0.12602 2 29 150 4 54 188 rs6888012 Imputed A REC 428 0.5862 0.2628 0.3502 0.9812 −2.032 0.04213 0.3793 0.44509 0.42896 0.45714 26 105 52 54 116 75 rs6908481 Imputed C REC 428 1.658 0.2609 0.9942 2.764 1.938 0.05267 0.5523 0.41939 0.42857 0.4126 38 80 64 34 135 77 rs7032231 Imputed A ADD 429 1.467 0.1469 1.1 1.957 2.609 0.00908 0.6651 0.3345 0.38251 0.29878 25 90 68 25 97 124 rs7067638 Imputed T DOM 431 1.82 0.2397 1.138 2.911 2.498 0.01249 0.03157 0.11717 0.15489 0.08907 8 41 135 3 38 206 rs7077799 Imputed A DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs7082163 Imputed A ADD 430 1.817 0.2063 1.213 2.722 2.895 0.0038 0.03378 0.1186 0.15847 0.08907 8 42 133 3 38 206 rs7082163 Imputed A DOM 430 1.875 0.239 1.173 2.995 2.629 0.00856 0.03378 0.1186 0.15847 0.08907 8 42 133 3 38 206 rs7089661 Imputed C DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs7101319 Imputed C ADD 430 1.817 0.2063 1.213 2.722 2.895 0.0038 0.03378 0.1186 0.15847 0.08907 8 42 133 3 38 206 rs7101319 Imputed C DOM 430 1.875 0.239 1.173 2.995 2.629 0.00856 0.03378 0.1186 0.15847 0.08907 8 42 133 3 38 206 rs710832 Genotyped A GEN 431 6.307 0.0427 0.1673 0.2587 0.24185 0.27126 4 81 99 19 96 132 rs710832 Genotyped A REC 431 0.256 0.5608 0.0853 0.7684 −2.43 0.01511 0.1673 0.2587 0.24185 0.27126 4 81 99 19 96 132 rs7134262 Imputed T GEN 418 3.095 0.2128 0.4064 0.38038 0.39888 0.36667 30 82 66 26 124 90 rs7134262 Imputed T REC 418 1.627 0.2899 0.9217 2.871 1.679 0.09319 0.4064 0.38038 0.39888 0.36667 30 82 66 26 124 90 rs7134671 Imputed T GEN 428 10.66 0.00484 0.03787 0.37033 0.4235 0.33061 42 71 70 27 108 110 rs7138300 Imputed C ADD 429 0.7714 0.144 0.5817 1.023 −1.803 0.07146 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs7138300 Imputed C DOM 429 0.5986 0.2106 0.3961 0.9045 −2.436 0.01484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs7138300 Imputed C GEN 429 6.21 0.04484 0.554 0.42774 0.39071 0.45528 31 81 71 44 136 66 rs7163931 Imputed G GEN 431 6.084 0.04773 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs7163931 Imputed G REC 431 3.183 0.4709 1.265 8.011 2.459 0.01395 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs7171486 Genotyped G DOM 431 0.5774 0.203 0.3878 0.8595 −2.706 0.00681 1 0.38747 0.33424 0.42713 21 81 82 44 123 80 rs7172611 Imputed G GEN 431 6.084 0.04773 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs7172611 Imputed G REC 431 3.183 0.4709 1.265 8.011 2.459 0.01395 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs7172689 Imputed T GEN 431 6.084 0.04773 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs7172689 Imputed T REC 431 3.183 0.4709 1.265 8.011 2.459 0.01395 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs7175701 Imputed C GEN 431 6.07 0.04808 0.7883 0.23202 0.25272 0.2166 16 61 107 8 91 148 rs7180245 Imputed A GEN 431 6.084 0.04773 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs7180245 Imputed A REC 431 3.183 0.4709 1.265 8.011 2.459 0.01395 0.8893 0.22274 0.25 0.20243 15 62 107 7 86 154 rs7220603 Genotyped A ADD 431 0.6302 0.1616 0.4591 0.865 −2.857 0.00428 0.04531 0.31671 0.2663 0.35425 8 82 94 26 123 98 rs7282518 Imputed T ADD 375 1.518 0.1836 1.06 2.176 2.275 0.02291 0.08335 0.184 0.225 0.15349 12 48 100 6 54 155 rs7283476 Imputed T ADD 429 0.6337 0.4061 0.2859 1.405 −1.123 0.2614 0.3657 0.03263 0.02459 0.03862 0 9 174 1 17 228 rs7283476 Imputed T DOM 429 0.6518 0.4222 0.2849 1.491 −1.014 0.3106 0.3657 0.03263 0.02459 0.03862 0 9 174 1 17 228 rs7295817 Imputed C GEN 427 1.689 0.4298 0.9199 0.40281 0.37912 0.42041 28 82 72 42 122 81 rs7298255 Imputed A ADD 430 0.7591 0.1447 0.5717 1.008 −1.905 0.05677 0.4311 0.42674 0.38798 0.45547 30 82 71 44 137 66 rs7298255 Imputed A DOM 430 0.594 0.2105 0.3932 0.8973 −2.475 0.01332 0.4311 0.42674 0.38798 0.45547 30 82 71 44 137 66 rs7305832 Imputed C GEN 431 3.043 0.2184 0.471 0.37355 0.3913 0.36032 30 84 70 26 126 95 rs7305832 Imputed C REC 431 1.616 0.2891 0.9169 2.847 1.66 0.09694 0.471 0.37355 0.3913 0.36032 30 84 70 26 126 95 rs7331467 Imputed A GEN 431 11.32 0.00349 0.4097 0.37007 0.39674 0.3502 38 70 76 25 123 99 rs7392620 Imputed C ADD 421 0.7494 0.1521 0.5562 1.01 −1.896 0.05801 0.8266 0.33135 0.29558 0.35833 13 81 87 32 108 100 rs742827 Imputed A ADD 423 1.374 0.1417 1.041 1.814 2.245 0.02479 0.1106 0.35461 0.3956 0.32365 30 84 68 31 94 116 rs742827 Imputed A GEN 423 5.635 0.05977 0.1106 0.35461 0.3956 0.32365 30 84 68 31 94 116 rs742827 Imputed A REC 423 1.393 0.2794 0.8055 2.408 1.186 0.2357 0.1106 0.35461 0.3956 0.32365 30 84 68 31 94 116 rs7446891 Imputed G DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs7448641 Imputed C ADD 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs7448641 Imputed C DOM 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs7484728 Imputed T GEN 429 10.78 0.00456 0.03857 0.37063 0.4235 0.3313 42 71 70 27 109 110 rs7499402 Genotyped A ADD 431 1.39 0.2523 0.8476 2.279 1.305 0.1919 0.7458 0.08005 0.09511 0.06883 2 31 151 1 32 214 rs7529851 Imputed A ADD 412 0.6637 0.1466 0.498 0.8846 −2.796 0.00517 0.8387 0.41141 0.35593 0.45319 23 80 74 48 117 70 rs7529851 Imputed A GEN 412 7.96 0.01868 0.8387 0.41141 0.35593 0.45319 23 80 74 48 117 70 rs7573951 Imputed G ADD 431 0.6931 0.1457 0.521 0.9221 −2.517 0.01184 0.6898 0.40371 0.35598 0.43927 22 87 75 46 125 76 rs7599198 Imputed T DOM 373 0.5474 0.2267 0.351 0.8537 −2.658 0.00787 0.599 0.42895 0.37742 0.4656 23 71 61 43 117 58 rs7600050 Imputed C ADD 408 1.511 0.1483 1.13 2.02 2.782 0.00541 0.6132 0.42892 0.48295 0.38793 41 88 47 31 118 83 rs7607712 Imputed T ADD 416 1.551 0.1747 1.101 2.185 2.513 0.01197 0.00491 0.25962 0.30114 0.22917 11 84 81 6 98 136 rs7607712 Imputed T DOM 416 1.544 0.2007 1.042 2.289 2.165 0.03037 0.00491 0.25962 0.30114 0.22917 11 84 81 6 98 136 rs7613492 Imputed G GEN 430 7.139 0.02817 0.02491 0.34535 0.39946 0.30488 34 79 71 28 94 124 rs7621663 Imputed G ADD 431 1.447 0.1393 1.102 1.901 2.655 0.00794 0.02563 0.34571 0.39946 0.30567 34 79 71 28 95 124 rs7621663 Imputed G GEN 431 7.055 0.02938 0.02563 0.34571 0.39946 0.30567 34 79 71 28 95 124 rs7621663 Imputed G REC 431 1.785 0.2775 1.036 3.075 2.089 0.03675 0.02563 0.34571 0.39946 0.30567 34 79 71 28 95 124 rs7626584 Imputed G ADD 431 0.5782 0.3624 0.2842 1.176 −1.511 0.1307 1 0.04524 0.03261 0.05466 0 12 172 0 27 220 rs7684899 Imputed C ADD 431 0.7399 0.1691 0.5312 1.031 −1.782 0.07475 0.8902 0.2239 0.19565 0.24494 10 52 122 12 97 138 rs7684899 Imputed C DOM 431 0.6359 0.2028 0.4273 0.9464 −2.232 0.02564 0.8902 0.2239 0.19565 0.24494 10 52 122 12 97 138 rs7701604 Imputed G ADD 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs7701604 Imputed G DOM 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs7703676 Imputed C ADD 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs7703676 Imputed C DOM 431 0.309 0.5694 0.1012 0.9434 −2.062 0.03918 1 0.0232 0.01087 0.03239 0 4 180 0 16 231 rs7708491 Imputed C REC 428 0.5862 0.2628 0.3502 0.9812 −2.032 0.04213 0.3793 0.44509 0.42896 0.45714 26 105 52 54 116 75 rs7711358 Imputed A DOM 431 0.7035 0.1964 0.4787 1.034 −1.791 0.07336 0.7398 0.32019 0.2962 0.33806 20 69 95 26 115 106 rs7719448 Imputed G REC 429 0.5823 0.2627 0.348 0.9745 −2.058 0.03958 0.3789 0.44522 0.42935 0.45714 26 106 52 54 116 75 rs7724761 Imputed T REC 418 0.5608 0.2705 0.3301 0.953 −2.138 0.03252 0.4268 0.439 0.42179 0.45188 24 103 52 52 112 75 rs7742476 Imputed T DOM 420 1.408 0.2046 0.9428 2.103 1.672 0.09449 0.6585 0.20952 0.23333 0.19167 9 66 105 11 70 159 rs7762993 Imputed A ADD 431 1.384 0.1852 0.963 1.99 1.756 0.07907 0.2535 0.18097 0.20652 0.16194 4 68 112 6 68 173 rs7762993 Imputed A DOM 431 1.506 0.206 1.006 2.255 1.987 0.04689 0.2535 0.18097 0.20652 0.16194 4 68 112 6 68 173 rs7767265 Imputed G ADD 423 1.375 0.168 0.9889 1.91 1.894 0.05828 0.6667 0.21513 0.24586 0.19215 9 71 101 12 69 161 rs7767265 Imputed G DOM 423 1.584 0.2032 1.064 2.359 2.263 0.02363 0.6667 0.21513 0.24586 0.19215 9 71 101 12 69 161 rs7768128 Imputed G REC 407 0.4807 0.4606 0.1949 1.186 −1.59 0.1118 0.4044 0.23219 0.21637 0.24364 7 60 104 18 79 139 rs7771264 Imputed T DOM 431 0.5289 0.2031 0.3552 0.7874 −3.137 0.00171 0.1775 0.23318 0.19022 0.26518 7 56 121 11 109 127 rs7773151 Genotyped C DOM 431 0.5304 0.202 0.357 0.7881 −3.139 0.0017 0.1465 0.24014 0.20109 0.26923 9 56 119 10 113 124 rs7773210 Genotyped A DOM 431 0.5304 0.202 0.357 0.7881 −3.139 0.0017 0.1465 0.24014 0.20109 0.26923 9 56 119 10 113 124 rs7808536 Imputed G DOM 429 1.939 0.2082 1.289 2.916 3.18 0.00147 1 0.18531 0.22951 0.15244 7 70 106 7 61 178 rs7843510 Genotyped G DOM 431 1.603 0.203 1.077 2.386 2.323 0.02015 0.6081 0.37471 0.4375 0.32794 38 85 61 25 112 110 rs7894867 Imputed T DOM 430 1.833 0.2398 1.146 2.932 2.527 0.01151 0.03174 0.11744 0.15574 0.08907 8 41 134 3 38 206 rs7921834 Imputed C DOM 430 1.458 0.197 0.9908 2.145 1.913 0.05576 0.4158 0.29419 0.32065 0.27439 18 82 84 23 89 134 rs7939893 Imputed C ADD 431 0.8337 0.1482 0.6235 1.115 −1.227 0.22 0.6712 0.34455 0.32337 0.36032 21 77 86 28 122 97 rs7939893 Imputed C DOM 431 0.7294 0.1979 0.4949 1.075 −1.594 0.1109 0.6712 0.34455 0.32337 0.36032 21 77 86 28 122 97 rs7944513 Imputed T GEN 410 5.096 0.07823 0.8957 0.25 0.28902 0.22152 16 68 89 10 85 142 rs7944513 Imputed T REC 410 2.257 0.4179 0.9952 5.12 1.949 0.05135 0.8957 0.25 0.28902 0.22152 16 68 89 10 85 142 rs7949720 Imputed G ADD 406 0.6348 0.2219 0.4109 0.9807 −2.048 0.0406 0.09887 0.12192 0.09281 0.14226 2 27 138 8 52 179 rs7949720 Imputed G DOM 406 0.6285 0.2538 0.3822 1.034 −1.83 0.06728 0.09887 0.12192 0.09281 0.14226 2 27 138 8 52 179 rs7955901 Imputed C ADD 429 0.7576 0.1448 0.5705 1.006 −1.918 0.05515 0.4895 0.42657 0.38736 0.45547 30 81 71 44 137 66 rs7955901 Imputed C DOM 429 0.5886 0.2107 0.3895 0.8896 −2.516 0.01189 0.4895 0.42657 0.38736 0.45547 30 81 71 44 137 66 rs7956274 Imputed T ADD 429 0.7688 0.1449 0.5788 1.021 −1.815 0.06949 0.3761 0.42541 0.38859 0.45306 30 83 71 43 136 66 rs7956274 Imputed T DOM 429 0.6074 0.2105 0.402 0.9176 −2.369 0.01786 0.3761 0.42541 0.38859 0.45306 30 83 71 43 136 66 rs7956274 Imputed T GEN 429 5.764 0.05601 0.3761 0.42541 0.38859 0.45306 30 83 71 43 136 66 rs7957932 Imputed G ADD 429 0.7693 0.1441 0.58 1.02 −1.819 0.06884 0.4321 0.4359 0.39946 0.46327 32 83 69 45 137 63 rs7957932 Imputed G DOM 429 0.5936 0.2123 0.3915 0.8999 −2.457 0.01402 0.4321 0.4359 0.39946 0.46327 32 83 69 45 137 63 rs7984504 Imputed C GEN 431 7.984 0.01846 0.5855 0.32831 0.3587 0.30567 30 72 82 19 113 115 rs7999518 Imputed A REC 385 0.6295 0.2746 0.3675 1.078 −1.686 0.09185 0.305 0.45065 0.42857 0.46652 24 90 47 49 111 64 rs8026245 Imputed G GEN 431 6.07 0.04808 0.7883 0.23202 0.25272 0.2166 16 61 107 8 91 148 rs8026245 Imputed G REC 431 2.977 0.4471 1.239 7.15 2.44 0.01469 0.7883 0.23202 0.25272 0.2166 16 61 107 8 91 148 rs8060725 Genotyped A ADD 431 0.7775 0.173 0.5539 1.091 −1.455 0.1456 0.774 0.21346 0.19022 0.23077 4 62 118 14 86 147 rs8103016 Genotyped A ADD 431 1.589 0.1785 1.12 2.254 2.594 0.0095 0.4503 0.19722 0.23641 0.16802 8 71 105 6 71 170 rs8103016 Genotyped A DOM 431 1.683 0.2037 1.129 2.508 2.555 0.01061 0.4503 0.19722 0.23641 0.16802 8 71 105 6 71 170 rs8104182 Imputed G ADD 431 1.613 0.1788 1.136 2.289 2.672 0.00754 0.5407 0.19606 0.23641 0.16599 8 71 105 6 70 171 rs8104182 Imputed G DOM 431 1.716 0.204 1.151 2.56 2.648 0.00811 0.5407 0.19606 0.23641 0.16599 8 71 105 6 70 171 rs8129461 Imputed G ADD 429 0.6337 0.4061 0.2859 1.405 −1.123 0.2614 0.3657 0.03263 0.02459 0.03862 0 9 174 1 17 228 rs8129461 Imputed G DOM 429 0.6518 0.4222 0.2849 1.491 −1.014 0.3106 0.3657 0.03263 0.02459 0.03862 0 9 174 1 17 228 rs8130021 Imputed G ADD 429 0.6337 0.4061 0.2859 1.405 −1.123 0.2614 0.3657 0.03263 0.02459 0.03862 0 9 174 1 17 228 rs8130021 Imputed G DOM 429 0.6518 0.4222 0.2849 1.491 −1.014 0.3106 0.3657 0.03263 0.02459 0.03862 0 9 174 1 17 228 rs879961 Imputed T ADD 430 0.7316 0.1563 0.5386 0.9938 −2 0.04552 0.5449 0.27442 0.2377 0.30162 15 57 111 20 109 118 rs879961 Imputed T DOM 430 0.5986 0.1985 0.4057 0.8831 −2.586 0.00971 0.5449 0.27442 0.2377 0.30162 15 57 111 20 109 118 rs906353 Imputed A DOM 431 0.6603 0.1967 0.4491 0.9708 −2.11 0.03482 0.6452 0.29698 0.26902 0.31781 18 63 103 22 113 112 rs915491 Imputed C DOM 431 1.452 0.1969 0.9867 2.135 1.892 0.0585 0.3349 0.2761 0.30163 0.25709 16 79 89 21 85 141 rs915493 Imputed T DOM 431 1.452 0.1969 0.9867 2.135 1.892 0.0585 0.3349 0.2761 0.30163 0.25709 16 79 89 21 85 141 rs915494 Imputed A ADD 392 1.279 0.1636 0.9278 1.762 1.502 0.1331 0.5983 0.25765 0.28485 0.23789 13 68 84 15 78 134 rs915494 Imputed A DOM 392 1.409 0.207 0.9389 2.114 1.656 0.0978 0.5983 0.25765 0.28485 0.23789 13 68 84 15 78 134 rs917295 Imputed G DOM 429 0.6749 0.197 0.4587 0.993 −1.996 0.04596 1 0.31585 0.28689 0.3374 18 69 96 25 116 105 rs9284851 Imputed A GEN 426 6.343 0.04195 0.03262 0.34859 0.39946 0.30992 34 79 71 28 94 120 rs9293464 Imputed T REC 429 0.5823 0.2627 0.348 0.9745 −2.058 0.03958 0.3789 0.44522 0.42935 0.45714 26 106 52 54 116 75 rs9295154 Genotyped G DOM 431 1.917 0.2188 1.249 2.943 2.974 0.00294 0.274 0.15777 0.19022 0.1336 5 60 119 9 48 190 rs9310221 Imputed A DOM 389 1.407 0.2186 0.917 2.16 1.563 0.118 1 0.40746 0.41768 0.4 23 91 50 41 98 86 rs9310699 Genotyped T GEN 431 7.563 0.02279 0.04132 0.34107 0.39674 0.2996 33 80 71 27 94 126 rs9310700 Imputed C ADD 431 1.447 0.1393 1.102 1.901 2.655 0.00794 0.02563 0.34571 0.39946 0.30567 34 79 71 28 95 124 rs9310700 Imputed C GEN 431 7.055 0.02938 0.02563 0.34571 0.39946 0.30567 34 79 71 28 95 124 rs9310701 Imputed G GEN 430 6.869 0.03224 0.03283 0.34651 0.39946 0.30691 34 79 71 28 95 123 rs9310704 Imputed G GEN 426 6.343 0.04195 0.03262 0.34859 0.39946 0.30992 34 79 71 28 94 120 rs9319185 Imputed C GEN 431 7.984 0.01846 0.5855 0.32831 0.3587 0.30567 30 72 82 19 113 115 rs9319186 Imputed T GEN 431 7.984 0.01846 0.5855 0.32831 0.3587 0.30567 30 72 82 19 113 115 rs9327555 Imputed T DOM 429 0.6887 0.197 0.4682 1.013 −1.893 0.05831 1 0.31702 0.28962 0.3374 18 70 95 25 116 105 rs9403367 Imputed C DOM 431 0.5304 0.202 0.357 0.7881 −3.139 0.0017 0.1465 0.24014 0.20109 0.26923 9 56 119 10 113 124 rs9419608 Imputed G REC 427 1.589 0.2251 1.022 2.47 2.059 0.03954 0.08119 0.48595 0.51381 0.46545 55 76 50 55 119 72 rs9426437 Imputed T DOM 426 0.6833 0.203 0.459 1.017 −1.876 0.06061 0.7588 0.38498 0.35714 0.40574 25 80 77 36 126 82 rs9454967 Imputed G DOM 431 2.24 0.3143 1.21 4.147 2.566 0.0103 0.1777 0.05916 0.08152 0.04251 1 28 155 2 17 228 rs9635511 Imputed T DOM 427 0.7034 0.2071 0.4687 1.055 −1.699 0.08928 0.108 0.40281 0.38525 0.41598 28 85 70 33 137 74 rs966583 Imputed A ADD 431 0.6846 0.1496 0.5106 0.9178 −2.533 0.01131 0.1622 0.40371 0.35326 0.4413 21 88 75 42 134 71 rs966583 Imputed A DOM 431 0.6092 0.2075 0.4056 0.915 −2.388 0.01694 0.1622 0.40371 0.35326 0.4413 21 88 75 42 134 71 rs980263 Imputed T GEN 431 6.792 0.0335 0.0334 0.34687 0.39946 0.30769 34 79 71 28 96 123 rs980264 Imputed T GEN 431 6.792 0.0335 0.0334 0.34687 0.39946 0.30769 34 79 71 28 96 123 rs9812206 Imputed G ADD 431 0.4853 0.2571 0.2932 0.8033 −2.812 0.00493 0.7864 0.09977 0.06793 0.12348 0 25 159 3 55 189 rs9812206 Imputed G DOM 431 0.4903 0.2646 0.2919 0.8236 −2.693 0.00707 0.7864 0.09977 0.06793 0.12348 0 25 159 3 55 189 rs9813552 Imputed G ADD 431 0.5098 0.2537 0.3101 0.8382 −2.656 0.00792 0.6016 0.10093 0.07065 0.12348 0 26 158 3 55 189 rs9813552 Imputed G DOM 431 0.5166 0.2615 0.3095 0.8625 −2.526 0.01154 0.6016 0.10093 0.07065 0.12348 0 26 158 3 55 189 rs9815037 Imputed T ADD 430 0.4609 0.2606 0.2765 0.7681 −2.972 0.00296 0.785 0.09884 0.06522 0.12398 0 24 160 3 55 188 rs9815037 Imputed T DOM 430 0.4643 0.2679 0.2746 0.7848 −2.864 0.00418 0.785 0.09884 0.06522 0.12398 0 24 160 3 55 188 rs9819583 Imputed T GEN 431 7.563 0.02279 0.04132 0.34107 0.39674 0.2996 33 80 71 27 94 126 rs9825349 Imputed A ADD 431 0.4629 0.2606 0.2778 0.7715 −2.955 0.00312 0.7849 0.09861 0.06522 0.12348 0 24 160 3 55 189 rs9825349 Imputed A DOM 431 0.4664 0.2679 0.2759 0.7884 −2.847 0.00441 0.7849 0.09861 0.06522 0.12348 0 24 160 3 55 189 rs9833118 Imputed G ADD 419 1.479 0.1411 1.122 1.95 2.774 0.00554 0.02381 0.34964 0.4073 0.30705 34 77 67 28 92 121 rs9833118 Imputed G GEN 419 7.693 0.02135 0.02381 0.34964 0.4073 0.30705 34 77 67 28 92 121 rs9834217 Imputed T ADD 430 0.4658 0.2606 0.2795 0.7764 −2.931 0.00338 0.785 0.09884 0.06557 0.12348 0 24 159 3 55 189 rs9834217 Imputed T DOM 430 0.4695 0.2679 0.2777 0.7937 −2.822 0.00477 0.785 0.09884 0.06557 0.12348 0 24 159 3 55 189 rs9838563 Imputed C GEN 430 6.869 0.03224 0.03283 0.34651 0.39946 0.30691 34 79 71 28 95 123 rs9840460 Imputed T ADD 431 0.4629 0.2606 0.2778 0.7715 −2.955 0.00312 0.7849 0.09861 0.06522 0.12348 0 24 160 3 55 189 rs9840460 Imputed T DOM 431 0.4664 0.2679 0.2759 0.7884 −2.847 0.00441 0.7849 0.09861 0.06522 0.12348 0 24 160 3 55 189 rs9840756 Imputed A ADD 431 0.4629 0.2606 0.2778 0.7715 −2.955 0.00312 0.7849 0.09861 0.06522 0.12348 0 24 160 3 55 189 rs9840756 Imputed A DOM 431 0.4664 0.2679 0.2759 0.7884 −2.847 0.00441 0.7849 0.09861 0.06522 0.12348 0 24 160 3 55 189 rs9847999 Imputed C GEN 426 6.343 0.04195 0.03262 0.34859 0.39946 0.30992 34 79 71 28 94 120 rs9864769 Imputed C GEN 431 6.792 0.0335 0.0334 0.34687 0.39946 0.30769 34 79 71 28 96 123 rs9866421 Genotyped C REC 431 0.6994 0.2578 0.4219 1.159 −1.387 0.1655 0.8452 0.43387 0.44022 0.42915 29 104 51 51 110 86 rs987296 Imputed T GEN 430 7.666 0.02164 0.03184 0.3407 0.39674 0.29878 33 80 71 27 93 126 rs9881685 Imputed A ADD 431 0.4853 0.2571 0.2932 0.8033 −2.812 0.00493 0.7864 0.09977 0.06793 0.12348 0 25 159 3 55 189 rs9881685 Imputed A DOM 431 0.4903 0.2646 0.2919 0.8236 −2.693 0.00707 0.7864 0.09977 0.06793 0.12348 0 25 159 3 55 189 rs992695 Imputed C ADD 431 0.7364 0.156 0.5424 0.9998 −1.961 0.04987 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs992695 Imputed C DOM 431 0.6065 0.198 0.4114 0.894 −2.526 0.01155 0.5472 0.27494 0.23913 0.30162 15 58 111 20 109 118 rs9936999 Imputed G DOM 249 1.779 0.2695 1.049 3.017 2.137 0.03256 0.6862 0.37349 0.42991 0.33099 18 56 33 15 64 63

TABLE 16 ALLELE SNP rs # SOURCE (A1) MODEL NMISS OR SE L95 U95 STAT P HW_PVALUE ALLELE_FREQ ATORVA_ALLELE_FREQ PRAVA_ALLELE_FREQ rs77638540 Genotyped T DOM 443 0.3879 0.3691 0.1881 0.7996 −2.566 0.0103 0.3489 0.05305 0.0314 0.0694 rs72746987 Genotyped A DOM 443 1.033 0.3495 0.5209 2.05 0.09422 0.9249 1 0.04176 0.0419 0.0417 rs10021016 Genotyped G GEN 443 6.477 0.03922 0.7144 0.26298 0.2984 0.2361 rs10021016 Genotyped G REC 443 2.482 0.3826 1.172 5.253 2.375 0.01753 0.7144 0.26298 0.2984 0.2361 rs10051148 Imputed C DOM 443 0.6399 0.1948 0.4368 0.9373 −2.293 0.02187 0.8242 0.30813 0.2801 0.3294 rs10054055 Imputed T DOM 440 0.5872 0.2006 0.3963 0.8702 −2.653 0.007974 0.3313 0.32841 0.2937 0.3546 rs10067895 Imputed A DOM 440 0.577 0.2025 0.388 0.8581 −2.716 0.006612 0.07522 0.34886 0.3132 0.376 rs10100725 Imputed C DOM 443 1.055 0.2111 0.6977 1.596 0.2549 0.7988 0.3323 0.17833 0.1859 0.1726 rs10128531 Imputed T ADD 415 1.662 0.2062 1.11 2.49 2.465 0.0137 0.677 0.13735 0.1742 0.1097 rs10181743 Imputed G ADD 417 1.137 0.1442 0.8575 1.509 0.8934 0.3716 0.6902 0.43046 0.4469 0.4181 rs10199127 Imputed T DOM 431 1.032 0.2018 0.6945 1.532 0.1537 0.8779 0.3263 0.32831 0.3155 0.3381 rs10270624 Imputed G DOM 409 1.374 0.2138 0.904 2.09 1.488 0.1368 0.7448 0.18582 0.2095 0.1674 rs1030006 Imputed G REC 434 0.87 0.2356 0.5483 1.381 −0.591 0.5545 0.7002 0.47005 0.4599 0.4777 rs1031811 Imputed A REC 434 2.698 0.3294 1.415 5.145 3.013 0.002589 0.7388 0.31567 0.361 0.2814 rs10430870 Genotyped G GEN 443 8.277 0.01594 0.7024 0.24831 0.2853 0.2202 rs10430870 Genotyped G REC 443 3.43 0.4334 1.467 8.021 2.84E+00 0.004451 0.7024 0.24831 0.2853 0.2202 rs10469597 Imputed A GEN 411 2.673 0.2627 0.5359 0.27494 0.2599 0.2863 rs10469597 Imputed A REC 411 1.249 0.4024 0.5677 2.749 0.5528 0.5804 0.5359 0.27494 0.2599 0.2863 rs10478919 Imputed G DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.009541 0.1134 0.34312 0.3089 0.369 rs10506623 Imputed C ADD 442 0.7806 0.1427 0.5901 1.033 −1.735 0.08266 0.6908 0.3948 0.3632 0.4187 rs10506623 Imputed C DOM 442 0.7185 0.204 0.4817 1.072 −1.621 0.1051 0.6908 0.3948 0.3632 0.4187 rs10506626 Imputed A ADD 443 0.7544 0.1415 0.5717 0.9954 −1.992 0.04634 0.5504 0.39391 0.356 0.4226 rs10506626 Imputed A DOM 443 0.6807 0.2015 0.4586 1.01 −1.909 0.05621 0.5504 0.39391 0.356 0.4226 rs10509477 Imputed T DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.3691 0.3075 rs10517918 Imputed G REC 433 0.972 0.2598 0.5841 1.618 −0.1092 0.9131 0.4917 0.42725 0.4309 0.4245 rs10517924 Imputed A REC 442 1.079 0.2382 0.6766 1.721 0.3198 0.7491 1 0.46154 0.466 0.4582 rs10519362 Imputed G DOM 434 1.656 0.2162 1.084 2.529 2.333 0.01967 0.5877 0.15668 0.1882 0.1331 rs10520072 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs10737390 Imputed T DOM 418 1.128 0.213 0.7431 1.712 0.5659 0.5715 0.3626 0.40909 0.419 0.4017 rs10742851 Imputed T REC 443 1.673 0.3727 0.8057 3.473 1.38 0.1675 0.4903 0.29007 0.3037 0.2798 rs10743685 Imputed G GEN 435 1.895 0.3878 0.1663 0.41379 0.4335 0.3988 rs10743685 Imputed G REC 435 1.446 0.2691 0.8531 2.45 1.37 0.1708 0.1663 0.41379 0.4335 0.3988 rs10749293 Imputed G DOM 441 1.442 0.1947 0.9847 2.113 1.881 0.05998 0.1901 0.322 0.3579 0.2948 rs10749294 Imputed A DOM 443 1.341 0.1934 0.9176 1.959 1.516 0.1296 0.2987 0.29007 0.3246 0.2639 rs10753760 Imputed T ADD 423 0.9252 0.1361 0.7085 1.208 −0.5713 0.5678 0.01675 0.41844 0.4108 0.4244 rs10753760 Imputed T GEN 423 0.3766 0.8284 0.01675 0.41844 0.4108 0.4244 rs10772362 Imputed T ADD 443 0.8356 0.1722 0.5962 1.171 −1.043 0.297 0.5807 0.22122 0.2068 0.2321 rs10784891 Imputed C ADD 422 0.7472 0.1404 0.5675 0.9839 −2.076 0.03794 0.4305 0.4455 0.4049 0.4769 rs10784891 Imputed C DOM 422 0.7374 0.2125 0.4862 1.118 −1.433 0.1518 0.4305 0.4455 0.4049 0.4769 rs10784891 Imputed C GEN 422 4.661 0.09727 0.4305 0.4455 0.4049 0.4769 rs10787923 Imputed G DOM 439 1.448 0.1952 0.9878 2.123 1.897 0.05785 0.1572 0.32232 0.359 0.2948 rs10787924 Imputed T DOM 443 1.341 0.1934 0.9176 1.959 1.516 0.1296 0.2987 0.29007 0.3246 0.2639 rs10787949 Imputed A DOM 442 1.352 0.1976 0.9177 1.991 1.525 0.1272 0.1377 0.33937 0.3717 0.3147 rs10787951 Imputed G DOM 441 1.349 0.1976 0.9157 1.987 1.514 0.1299 0.1364 0.339 0.3711 0.3147 rs10787983 Imputed C DOM 441 1.351 0.1964 0.9194 1.986 1.532 0.1255 0.1642 0.33447 0.3691 0.308 rs10794733 Imputed C ADD 439 0.6594 0.1519 0.4896 0.888 −2.742 0.006112 0.578 0.31093 0.2605 0.3494 rs10818280 Imputed C DOM 432 0.6208 0.201 0.4186 0.9206 −2.371 0.01772 0.347 0.28588 0.2433 0.3184 rs10860586 Imputed A ADD 431 0.9019 0.1389 0.6869 1.184 −0.7436 0.4571 0.9232 0.5058 0.4892 0.5183 rs10860586 Imputed A GEN 431 0.568 0.7528 0.9232 0.5058 0.4892 0.5183 rs10870473 Imputed A ADD 177 1.273 0.2526 0.7757 2.088 0.9544 0.3399 1 0.29944 0.3209 0.2864 rs10870473 Imputed A DOM 177 1.887 0.3386 0.9717 3.664 1.875 0.06077 1 0.29944 0.3209 0.2864 rs10879240 Imputed C ADD 428 0.7296 0.1403 0.5542 0.9605 −2.247 0.02462 0.434 0.44743 0.4043 0.4813 rs10879240 Imputed C GEN 428 5.7 0.05785 0.434 0.44743 0.4043 0.4813 rs10879242 Imputed A ADD 421 0.7715 0.1445 0.5812 1.024 −1.795 0.07269 0.9197 0.40855 0.373 0.4364 rs10879242 Imputed A DOM 421 0.7102 0.2081 0.4724 1.068 −1.644 0.1001 0.9197 0.40855 0.373 0.4364 rs10879245 Imputed G ADD 421 0.7715 0.1445 0.5812 1.024 −1.795 0.07269 0.9197 0.40855 0.373 0.4364 rs10879245 Imputed G DOM 421 0.7102 0.2081 0.4724 1.068 −1.644 0.1001 0.9197 0.40855 0.373 0.4364 rs10879249 Imputed T ADD 440 0.7823 0.1427 0.5914 1.035 −1.72 0.08541 0.7662 0.39773 0.3658 0.422 rs10879249 Imputed T DOM 440 0.7247 0.2038 0.486 1.081 −1.58 0.1141 0.7662 0.39773 0.3658 0.422 rs10886429 Imputed A DOM 441 1.296 0.1967 0.8811 1.905 1.316 0.1881 0.1642 0.33447 0.3665 0.31 rs10886449 Imputed G DOM 440 1.337 0.1968 0.9089 1.966 1.475 0.1403 0.1168 0.30795 0.3474 0.278 rs10886451 Imputed G DOM 440 1.337 0.1968 0.9089 1.966 1.475 0.1403 0.1168 0.30795 0.3474 0.278 rs10886452 Imputed A DOM 440 1.376 0.1972 0.9349 2.025 1.619 0.1055 0.1648 0.33523 0.3737 0.306 rs10886456 Imputed G DOM 440 1.337 0.1968 0.9089 1.966 1.475 0.1403 0.1168 0.30795 0.3474 0.278 rs10886463 Imputed C DOM 442 1.352 0.1976 0.9177 1.991 1.525 0.1272 0.1118 0.3405 0.3743 0.3147 rs10886465 Imputed A DOM 441 1.355 0.1976 0.9197 1.995 1.536 0.1245 0.1364 0.339 0.3743 0.312 rs10886526 Imputed C DOM 439 1.364 0.197 0.9275 2.007 1.578 0.1146 0.2383 0.33257 0.3677 0.306 rs10922903 Imputed C REC 440 0.9678 0.2533 0.5891 1.59 −0.1294 0.897 0.8458 0.43068 0.4418 0.4223 rs10941126 Imputed G ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.0734 rs10941126 Imputed G DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.0734 rs10947980 Imputed G ADD 439 1.004 0.1592 0.7347 1.371 0.0233 0.9814 0.4609 0.2631 0.2632 0.2631 rs11059376 Imputed T ADD 401 1.086 0.1953 0.7409 1.593 0.424 0.6716 1 0.16459 0.1695 0.1608 rs11072995 Imputed T GEN 439 3.28 0.194 0.295 0.19932 0.2237 0.1807 rs11072995 Imputed T REC 439 2.198 0.4614 0.8897 5.43 1.707 0.08787 0.295 0.19932 0.2237 0.1807 rs11081202 Genotyped G GEN 443 8.643 0.01328 0.456 0.25621 0.288 0.2321 rs11081202 Genotyped G REC 443 3.218 0.3982 1.475 7.022 2.935 0.003332 0.456 0.25621 0.288 0.2321 rs110965 Imputed C GEN 420 11.84 0.002689 0.9143 0.34643 0.3984 0.3067 rs11124962 Imputed A DOM 437 1.26 0.1969 0.8568 1.854 1.175 0.2401 0.3787 0.25515 0.2632 0.249 rs1116596 Imputed T DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.009541 0.1134 0.34312 0.3089 0.369 rs11178531 Imputed A ADD 439 0.7197 0.1371 0.5501 0.9416 −2.399 0.01643 0.3881 0.46811 0.4211 0.504 rs11178531 Imputed A DOM 439 0.6936 0.2116 0.4581 1.05 −1.729 0.08386 0.3881 0.46811 0.4211 0.504 rs11178583 Imputed A ADD 443 0.7883 0.1424 0.5963 1.042 −1.671 0.09473 0.6922 0.39503 0.3639 0.4187 rs11178583 Imputed A DOM 443 0.7338 0.2032 0.4927 1.093 −1.523 0.1277 0.6922 0.39503 0.3639 0.4187 rs11178589 Imputed T ADD 437 0.7796 0.1432 0.5888 1.032 −1.739 0.08199 0.8419 0.39931 0.3658 0.4251 rs11178589 Imputed T DOM 437 0.7215 0.2047 0.4831 1.078 −1.595 0.1108 0.8419 0.39931 0.3658 0.4251 rs11178594 Imputed C ADD 441 0.7716 0.1422 0.584 1.02 −1.824 0.06814 1 0.40249 0.3684 0.4283 rs11178594 Imputed C DOM 441 0.7044 0.202 0.4741 1.046 −1.735 0.08274 1 0.40249 0.3684 0.4283 rs11178602 Imputed T ADD 439 0.7699 0.1424 0.5824 1.018 −1.836 0.06634 1 0.40205 0.3677 0.428 rs11178602 Imputed T DOM 439 0.7005 0.2027 0.4709 1.042 −1.757 0.079 1 0.40205 0.3677 0.428 rs11178648 Imputed T ADD 440 0.754 0.1419 0.5709 0.9958 −1.99 0.04664 0.4852 0.39432 0.3571 0.4223 rs11178648 Imputed T DOM 440 0.6786 0.2027 0.4561 1.01 −1.912 0.05581 0.4852 0.39432 0.3571 0.4223 rs11198877 Imputed T DOM 441 1.369 0.1971 0.9302 2.014 1.593 0.1113 0.1996 0.3356 0.3737 0.3068 rs11198942 Imputed T DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.3691 0.3075 rs11221075 Imputed A ADD 417 0.4912 0.2448 0.304 0.7936 −2.904 0.003685 1 0.11391 0.0754 0.1429 rs11242020 Imputed T DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.009541 0.1134 0.34312 0.3089 0.369 rs11242021 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs11242022 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs11242023 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs1149349 Imputed T DOM 434 1.154 0.221 0.7482 1.779 0.6474 0.5174 0.4627 0.15323 0.1508 0.1551 rs1149350 Imputed A ADD 443 0.7733 0.1679 0.5564 1.075 −1.531 0.1258 0.01047 0.21445 0.1885 0.2341 rs1149350 Imputed A DOM 443 0.8901 0.2092 0.5906 1.341 −0.5566 0.5778 0.01047 0.21445 0.1885 0.2341 rs11576627 Imputed T ADD 441 1.439 0.1975 0.977 2.119 1.842 0.06547 0.01289 0.12358 0.15 0.1036 rs11576627 Imputed T DOM 441 1.57 0.2354 0.9899 2.491 1.917 0.05525 0.01289 0.12358 0.15 0.1036 rs11630050 Imputed G GEN 442 2.296 0.3173 1 0.23416 0.2539 0.2191 rs11630050 Imputed G REC 442 1.888 0.4309 0.8114 4.394 1.475 0.1402 1 0.23416 0.2539 0.2191 rs11633024 Imputed C GEN 442 2.296 0.3173 1 0.23416 0.2539 0.2191 rs11633024 Imputed C REC 442 1.888 0.4309 0.8114 4.394 1.475 0.1402 1 0.23416 0.2539 0.2191 rs11636298 Imputed G GEN 443 2.593 0.2734 0.5733 0.21332 0.2356 0.1964 rs11636298 Imputed G REC 443 1.965 0.4472 0.8177 4.72 1.51 0.1311 0.5733 0.21332 0.2356 0.1964 rs11637363 Imputed C GEN 420 2.573 0.2762 0.7866 0.23452 0.2527 0.2203 rs11637363 Imputed C REC 420 1.982 0.4368 0.842 4.666 1.566 0.1173 0.7866 0.23452 0.2527 0.2203 rs11637813 Imputed A GEN 442 2.296 0.3173 1 0.23416 0.2539 0.2191 rs11637813 Imputed A REC 442 1.888 0.4309 0.8114 4.394 1.475 0.1402 1 0.23416 0.2539 0.2191 rs11638043 Imputed C GEN 420 2.573 0.2762 0.7866 0.23452 0.2527 0.2203 rs11638043 Imputed C REC 420 1.982 0.4368 0.842 4.666 1.566 0.1173 0.7866 0.23452 0.2527 0.2203 rs11638115 Imputed A GEN 439 3.28 0.194 0.295 0.19932 0.2237 0.1807 rs11638115 Imputed A REC 439 2.198 0.4614 0.8897 5.43 1.707 0.08787 0.295 0.19932 0.2237 0.1807 rs11638444 Imputed C GEN 442 2.07 0.3552 0.4848 0.21606 0.2368 0.2004 rs11682946 Imputed A ADD 86 3.591 0.6209 1.063 12.13 2.059 0.03949 1 0.09884 0.15 0.0543 rs11682946 Imputed A DOM 86 3.591 0.6209 1.063 12.13 2.059 0.03949 1 0.09884 0.15 0.0543 rs11717157 Imputed T ADD 442 1.051 0.1481 0.786 1.405 0.3342 0.7382 0.662 0.319 0.3246 0.3147 rs11717157 Imputed T GEN 442 0.8899 0.6408 0.662 0.319 0.3246 0.3147 rs11724055 Imputed A DOM 443 0.5373 0.2207 0.3486 0.828 −2.816 0.004869 0.6032 0.16253 0.1283 0.1885 rs11743355 Imputed C ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.0734 rs11743355 Imputed C DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.0734 rs11746806 Imputed T ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.0734 rs11746806 Imputed T DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.0734 rs11746959 Imputed T ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.0734 rs11746959 Imputed T DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.0734 rs11749272 Imputed T DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.009541 0.1134 0.34312 0.3089 0.369 rs11839636 Imputed C GEN 441 0.9349 0.6266 0.4378 0.31293 0.2989 0.3234 rs11839785 Imputed C GEN 441 0.9349 0.6266 0.4378 0.31293 0.2989 0.3234 rs11853619 Imputed C GEN 440 2.44 0.2953 0.5684 0.2125 0.2342 0.196 rs11853619 Imputed C REC 440 1.946 0.4474 0.8098 4.677 1.488 0.1367 0.5684 0.2125 0.2342 0.196 rs11856780 Imputed A GEN 440 2.44 0.2953 0.5684 0.2125 0.2342 0.196 rs11856780 Imputed A REC 440 1.946 0.4474 0.8098 4.677 1.488 0.1367 0.5684 0.2125 0.2342 0.196 rs11901899 Imputed A DOM 426 1.452 0.1995 0.9821 2.147 1.869 0.06157 0.3322 0.27582 0.3071 0.2521 rs11903290 Imputed C REC 434 2.698 0.3294 1.415 5.145 3.013 0.002589 0.7388 0.31567 0.361 0.2814 rs11909480 Imputed G ADD 439 0.4305 0.3702 0.2084 0.8894 −2.277 0.02282 0.2386 0.0467 0.0263 0.0622 rs11909480 Imputed G DOM 439 0.3714 0.3963 0.1708 0.8077 −2.499 0.01246 0.2386 0.0467 0.0263 0.0622 rs11910289 Imputed T ADD 440 1.815 0.2555 1.1 2.995 2.334 0.01959 0.1085 0.08409 0.1099 0.0643 rs11910289 Imputed T DOM 440 1.911 0.2846 1.094 3.339 2.276 0.02285 0.1085 0.08409 0.1099 0.0643 rs11920375 Genotyped C GEN 443 1.788 0.4089 0.8294 0.32844 0.3351 0.3234 rs11926319 Imputed G DOM 443 1.007 0.269 0.5945 1.706 0.02639 0.9789 0.4982 0.07675 0.0759 0.0774 rs11933744 Imputed T REC 440 0.8701 0.3394 0.4473 1.692 −0.4099 0.6819 0.3677 0.30455 0.2804 0.3227 rs11934919 Imputed C REC 441 0.8636 0.341 0.4426 1.685 −0.43 0.6672 0.4994 0.30159 0.2778 0.3194 rs11934957 Imputed C REC 441 0.8636 0.341 0.4426 1.685 −0.43 0.6672 0.4994 0.30159 0.2778 0.3194 rs11959206 Imputed A REC 434 1.201 0.2381 0.7533 1.916 0.7701 0.4412 0.923 0.45853 0.4545 0.4615 rs12038613 Imputed C REC 404 0.8998 0.2554 0.5454 1.484 −0.4136 0.6791 0.9202 0.44678 0.4483 0.4457 rs12151417 Imputed T DOM 442 1.517 0.199 1.027 2.241 2.095 0.03616 0.8879 0.21493 0.2435 0.1932 rs12153185 Imputed T DOM 441 0.5728 0.2023 0.3853 0.8516 −2.754 0.005893 0.07489 0.35034 0.3132 0.3785 rs12182651 Imputed T DOM 441 0.9744 0.2621 0.583 1.629 −0.09893 0.9212 0.07328 0.0907 0.0895 0.0916 rs12235345 Imputed C DOM 443 1.768 0.3192 0.9457 3.305 1.785 0.07424 0.3489 0.05305 0.0707 0.0397 rs12324786 Imputed T GEN 439 3.28 0.194 0.295 0.19932 0.2237 0.1807 rs12324786 Imputed T REC 439 2.198 0.4614 0.8897 5.43 1.707 0.08787 0.295 0.19932 0.2237 0.1807 rs12336958 Imputed G DOM 407 0.7989 0.209 0.5304 1.203 −1.074 0.2826 0.9166 0.38452 0.3621 0.4013 rs12407412 Imputed C ADD 441 1.439 0.1975 0.977 2.119 1.842 0.06547 0.01289 0.12358 0.15 0.1036 rs12407412 Imputed C DOM 441 1.57 0.2354 0.9899 2.491 1.917 0.05525 0.01289 0.12358 0.15 0.1036 rs12418971 Imputed C GEN 436 8.323 0.01558 0.6068 0.24771 0.2884 0.2166 rs12418971 Imputed C REC 436 3.381 0.4338 1.445 7.911 2.808 0.004979 0.6068 0.24771 0.2884 0.2166 rs1241967 Imputed T REC 443 0.6598 0.3096 0.3596 1.211 −1.343 0.1794 0.6028 0.35214 0.3429 0.3591 rs12420184 Imputed G DOM 438 1.429 0.2168 0.9343 2.185 1.647 0.09966 1 0.14954 0.1693 0.1345 rs12433968 Imputed T DOM 419 1.059 0.1998 0.7158 1.566 0.2862 0.7747 0.0315 0.31623 0.3197 0.3136 rs12445477 Imputed A DOM 427 0.7231 0.2709 0.4252 1.23 −1.197 0.2315 0.3613 0.08899 0.0788 0.0967 rs12447191 Genotyped T ADD 443 0.7641 0.1931 0.5233 1.116 −1.393 0.1636 0.8583 0.15801 0.1387 0.1726 rs12447191 Genotyped T DOM 443 0.6902 0.216 0.452 1.054 −1.716 0.08611 0.8583 0.15801 0.1387 0.1726 rs12465349 Imputed A REC 434 1.865 0.2195 1.213 2.867 2.839 0.004525 0.8461 0.55069 0.5775 0.5304 rs1247340 Imputed C ADD 441 0.7681 0.1723 0.548 1.077 −1.531 0.1257 0.0397 0.20522 0.1789 0.2251 rs1247340 Imputed C DOM 441 0.9041 0.2098 0.5993 1.364 −0.4802 0.6311 0.0397 0.20522 0.1789 0.2251 rs1247341 Imputed C ADD 441 0.7805 0.1735 0.5555 1.097 −1.428 0.1532 0.05636 0.20408 0.1806 0.222 rs1247341 Imputed C DOM 441 0.919 0.2102 0.6087 1.387 −0.4021 0.6876 0.05636 0.20408 0.1806 0.222 rs1247343 Imputed C DOM 441 1.064 0.2203 0.6907 1.638 0.2798 0.7797 0.03783 0.1644 0.15 0.1753 rs12509758 Imputed C DOM 436 1.34 0.2022 0.9013 1.991 1.446 0.1481 0.1442 0.20757 0.2193 0.1988 rs12515472 Imputed A DOM 443 1.913 0.2164 1.252 2.923 2.997 0.002728 0.8546 0.1535 0.1937 0.123 rs12548906 Imputed G ADD 415 1.763 0.1813 1.236 2.516 3.128 0.00176 1 0.19639 0.2458 0.1597 rs12596240 Imputed G DOM 443 0.9009 0.205 0.6028 1.346 −0.509 0.6107 0.9223 0.41986 0.3953 0.4385 rs12618781 Imputed A DOM 440 1.082 0.2178 0.7061 1.658 0.3618 0.7175 0.8483 0.47045 0.4709 0.4701 rs12678600 Imputed A DOM 439 0.7992 0.198 0.5421 1.178 −1.132 0.2575 1 0.31663 0.2989 0.33 rs12692229 Imputed T ADD 443 1.608 0.1488 1.202 2.153 3.194 0.001404 0.4038 0.35102 0.4084 0.3075 rs12713324 Imputed T DOM 443 1.501 0.1987 1.017 2.215 2.043 0.04105 0.8886 0.21558 0.2435 0.1944 rs12719415 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs12820589 Imputed G ADD 418 0.882 0.1789 0.6212 1.252 −0.7022 0.4826 1 0.19856 0.1875 0.2073 rs12820589 Imputed G DOM 418 0.926 0.2078 0.6162 1.392 −0.3697 0.7116 1 0.19856 0.1875 0.2073 rs12831292 Imputed G ADD 436 0.7739 0.1429 0.5848 1.024 −1.794 0.0728 1 0.40367 0.371 0.428 rs12831292 Imputed G DOM 436 0.7047 0.2039 0.4725 1.051 −1.716 0.08609 1 0.40367 0.371 0.428 rs13012636 Imputed G REC 433 2.717 0.3295 1.424 5.183 3.034 0.002417 0.739 0.3164 0.3629 0.2814 rs13038146 Imputed C ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.3874 0.3115 rs13038146 Imputed C GEN 443 6.692 0.03523 0.2479 0.34424 0.3874 0.3115 rs13038146 Imputed C REC 443 2.069 0.2898 1.172 3.65 2.508 0.01214 0.2479 0.34424 0.3874 0.3115 rs13089860 Imputed A DOM 364 0.5987 0.2307 0.3809 0.941 −2.224 0.02617 0.02707 0.46429 0.4325 0.49 rs13102419 Imputed T REC 439 1.104 0.2389 0.6915 1.764 0.4158 0.6775 1 0.46128 0.4684 0.4558 rs13194907 Imputed A ADD 443 1.091 0.2583 0.6574 1.81 0.3362 0.7367 0.279 0.07336 0.0759 0.0714 rs13194907 Imputed A DOM 443 1.162 0.2804 0.6707 2.013 0.5355 0.5923 0.279 0.07336 0.0759 0.0714 rs13195745 Imputed A ADD 443 1.091 0.2583 0.6574 1.81 0.3362 0.7367 0.279 0.07336 0.0759 0.0714 rs13195745 Imputed A DOM 443 1.162 0.2804 0.6707 2.013 0.5355 0.5923 0.279 0.07336 0.0759 0.0714 rs13265054 Imputed T DOM 434 0.7541 0.1998 0.5098 1.116 −1.413 0.1577 0.8248 0.31567 0.2941 0.332 rs13273002 Imputed A GEN 443 0.08764 0.9571 0.8776 0.19074 0.1859 0.1944 rs13282131 Imputed C ADD 440 1.295 0.1396 0.9848 1.702 1.85 0.06426 0.8464 0.43864 0.4711 0.414 rs13282131 Imputed C GEN 440 6.641 0.03614 0.8464 0.43864 0.4711 0.414 rs13282131 Imputed C REC 440 1.884 0.247 1.161 3.057 2.564 0.01034 0.8464 0.43864 0.4711 0.414 rs1330052 Imputed G GEN 443 1.596 0.4502 1 0.34876 0.3325 0.3611 rs1335721 Imputed A REC 406 0.8982 0.2552 0.5447 1.481 −0.4207 0.674 0.9203 0.44581 0.4486 0.4437 rs1336382 Imputed T DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.3691 0.3075 rs1336383 Imputed T DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.3691 0.3075 rs1336407 Imputed T DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.3691 0.3088 rs1336409 Imputed T DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.3691 0.3088 rs1336596 Imputed A DOM 440 0.9849 0.205 0.659 1.472 −0.07439 0.9407 0.4737 0.36932 0.3763 0.364 rs13387284 Imputed A DOM 408 1.094 0.2214 0.7089 1.689 0.4062 0.6846 0.2701 0.4424 0.4454 0.4402 rs13401462 Imputed C DOM 417 0.8697 0.2292 0.555 1.363 −0.609 0.5425 0.6243 0.5024 0.5056 0.5 rs13409045 Imputed T ADD 442 1.009 0.1374 0.7712 1.321 0.06836 0.9455 0.2878 0.43891 0.4398 0.4382 rs1349284 Imputed C GEN 443 0.308 0.8573 0.5114 0.31828 0.322 0.3155 rs1355715 Imputed T ADD 442 0.6617 0.3179 0.3549 1.234 −1.299 0.1939 1 0.05769 0.0471 0.0657 rs1357696 Imputed A GEN 434 2.08 0.3535 0.9152 0.34332 0.3503 0.3381 rs1357698 Imputed A GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs1357699 Imputed T GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs1363273 Imputed C REC 421 0.9417 0.2317 0.598 1.483 −0.2592 0.7955 0.9225 0.49169 0.4809 0.5 rs1373601 Imputed A DOM 404 0.9323 0.2122 0.6151 1.413 −0.3303 0.7412 0.3414 0.37871 0.3882 0.3718 rs1375829 Imputed C GEN 443 0.308 0.8573 0.5114 0.31828 0.322 0.3155 rs1395748 Imputed G DOM 441 1.231 0.195 0.8402 1.804 1.067 0.2859 0.6571 0.30952 0.322 0.3 rs1414865 Imputed T DOM 442 1.352 0.1976 0.9177 1.991 1.525 0.1272 0.1377 0.33937 0.3717 0.3147 rs1414873 Imputed A DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.3691 0.3088 rs1414876 Imputed C DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.3691 0.3088 rs1424643 Imputed G ADD 430 1.447 0.1648 1.048 1.999 2.244 0.02486 0.4845 0.22209 0.2609 0.1931 rs1424643 Imputed G DOM 430 1.694 0.2023 1.14 2.518 2.606 0.009171 0.4845 0.22209 0.2609 0.1931 rs1424648 Imputed T DOM 438 1.609 0.2007 1.085 2.384 2.368 0.01786 0.5746 0.21804 0.2526 0.1915 rs1429321 Imputed A DOM 432 1.519 0.2006 1.025 2.251 2.084 0.03713 0.6699 0.21644 0.246 0.1939 rs1429326 Imputed T ADD 433 1.404 0.1719 1.003 1.967 1.975 0.04831 0.6569 0.20208 0.234 0.1776 rs1429326 Imputed T DOM 433 1.574 0.2049 1.053 2.352 2.213 0.02687 0.6569 0.20208 0.234 0.1776 rs1444741 Imputed A DOM 407 0.9777 0.2088 0.6493 1.472 −0.1082 0.9138 0.2366 0.35627 0.3713 0.3453 rs1449916 Imputed C DOM 270 0.7246 0.2903 0.4102 1.28 −1.11 0.2671 0.464 0.52222 0.5042 0.5362 rs1459523 Imputed A ADD 442 1.051 0.1481 0.786 1.405 0.3342 0.7382 0.662 0.319 0.3246 0.3147 rs1459523 Imputed A GEN 442 0.8899 0.6408 0.662 0.319 0.3246 0.3147 rs1466352 Imputed T GEN 443 1.33 0.5142 0.9151 0.33409 0.3429 0.3274 rs1466353 Imputed G GEN 443 1.33 0.5142 0.9151 0.33409 0.3429 0.3274 rs1476714 Imputed A DOM 439 0.5924 0.2025 0.3983 0.8811 −2.585 0.009742 0.1129 0.3451 0.3132 0.3695 rs1486723 Imputed C REC 434 0.5711 0.3144 0.3084 1.058 −1.782 0.07477 0.3533 0.36866 0.3351 0.3936 rs1495375 Imputed A ADD 421 0.7715 0.1445 0.5812 1.024 −1.795 0.07269 0.9197 0.40855 0.373 0.4364 rs1495375 Imputed A DOM 421 0.7102 0.2081 0.4724 1.068 −1.644 0.1001 0.9197 0.40855 0.373 0.4364 rs1495381 Imputed T GEN 442 7.762 0.02063 0.2705 0.38575 0.4342 0.3492 rs1495381 Imputed T REC 442 2.08 0.2834 1.194 3.626 2.584 0.009753 0.2705 0.38575 0.4342 0.3492 rs1498061 Imputed C ADD 200 0.6227 0.2741 0.3639 1.066 −1.728 0.084 0.4882 0.19 0.1446 0.2222 rs1498992 Imputed G DOM 428 0.7274 0.1999 0.4916 1.076 −1.592 0.1114 0.4588 0.35047 0.3234 0.3709 rs1499001 Imputed T DOM 437 0.7573 0.1974 0.5144 1.115 −1.409 0.159 0.2889 0.28375 0.262 0.3 rs1512988 Imputed A ADD 442 0.7806 0.1427 0.5901 1.033 −1.735 0.08266 0.6908 0.3948 0.3632 0.4187 rs1512988 Imputed A DOM 442 0.7185 0.204 0.4817 1.072 −1.621 0.1051 0.6908 0.3948 0.3632 0.4187 rs1512989 Imputed T ADD 442 0.7806 0.1427 0.5901 1.033 −1.735 0.08266 0.6908 0.3948 0.3632 0.4187 rs1512989 Imputed T DOM 442 0.7185 0.204 0.4817 1.072 −1.621 0.1051 0.6908 0.3948 0.3632 0.4187 rs1512991 Imputed T ADD 425 0.7106 0.1399 0.5401 0.9348 −2.442 0.01462 0.3804 0.45647 0.4071 0.4938 rs1512991 Imputed T DOM 425 0.6965 0.2131 0.4587 1.057 −1.698 0.08957 0.3804 0.45647 0.4071 0.4938 rs1512991 Imputed T GEN 425 6.384 0.0411 0.3804 0.45647 0.4071 0.4938 rs1524303 Imputed T GEN 436 1.005 0.6051 0.7421 0.32225 0.3298 0.3165 rs1524306 Imputed C ADD 441 1.05 0.1481 0.7851 1.403 0.3265 0.744 0.6626 0.31973 0.3246 0.316 rs1524306 Imputed C GEN 441 0.8672 0.6482 0.6626 0.31973 0.3246 0.316 rs1524310 Imputed G ADD 438 1.063 0.1488 0.7944 1.424 0.4133 0.6794 0.6604 0.31735 0.3237 0.3125 rs1524310 Imputed G GEN 438 0.7768 0.6781 0.6604 0.31735 0.3237 0.3125 rs1524321 Imputed C GEN 441 1.192 0.5511 1 0.33107 0.3429 0.322 rs1527059 Imputed A DOM 441 0.4524 0.2645 0.2693 0.7598 −2.999 0.002712 0.1053 0.09977 0.0684 0.1235 rs152707 Imputed A ADD 443 1.066 0.1385 0.8128 1.399 0.4637 0.6429 0.8451 0.41422 0.4241 0.4067 rs152707 Imputed A GEN 443 0.2887 0.8656 0.8451 0.41422 0.4241 0.4067 rs152712 Genotyped C ADD 443 1.066 0.1385 0.8128 1.399 0.4637 0.6429 0.8451 0.41422 0.4241 0.4067 rs152712 Genotyped C GEN 443 0.2887 0.8656 0.8451 0.41422 0.4241 0.4067 rs1533994 Imputed T GEN 443 1.33 0.5142 0.9151 0.33409 0.3429 0.3274 rs1535866 Imputed G DOM 440 1.405 0.2003 0.9487 2.081 1.697 0.08971 0.6667 0.21023 0.2263 0.198 rs1563773 Imputed T GEN 439 1.172 0.5564 0.9151 0.33599 0.3439 0.33 rs1563774 Imputed T GEN 439 1.172 0.5564 0.9151 0.33599 0.3439 0.33 rs1567740 Imputed T ADD 439 0.7805 0.1427 0.59 1.032 −1.736 0.08253 0.8422 0.39863 0.3658 0.4237 rs1567740 Imputed T DOM 439 0.7204 0.2038 0.4831 1.074 −1.609 0.1076 0.8422 0.39863 0.3658 0.4237 rs1572573 Imputed A DOM 396 1.019 0.2128 0.6715 1.546 0.08849 0.9295 0.00264 0.18813 0.1879 0.1883 rs1577497 Imputed C REC 408 0.899 0.2549 0.5455 1.481 −0.418 0.676 0.9204 0.44485 0.446 0.444 rs1581514 Imputed T ADD 429 1.06 0.1488 0.7919 1.419 0.3912 0.6957 0.8269 0.32751 0.3351 0.3217 rs1581514 Imputed T GEN 429 1.004 0.6052 0.8269 0.32751 0.3351 0.3217 rs1582321 Imputed T DOM 443 0.9009 0.205 0.6028 1.346 −0.509 0.6107 0.9223 0.41986 0.3953 0.4385 rs1582322 Imputed A DOM 438 0.8697 0.2066 0.5801 1.304 −0.6757 0.4992 0.7686 0.41895 0.3947 0.4375 rs1582323 Imputed A DOM 437 0.8751 0.2067 0.5836 1.312 −0.6457 0.5185 0.6949 0.41762 0.3947 0.4352 rs1592485 Imputed C DOM 443 0.8723 0.2093 0.5787 1.315 −0.653 0.5138 0.5 0.44131 0.4162 0.4603 rs1600954 Imputed T ADD 423 1.193 0.1389 0.909 1.567 1.273 0.203 0.6267 0.47754 0.5027 0.458 rs1600954 Imputed T GEN 423 1.735 0.4199 0.6267 0.47754 0.5027 0.458 rs16938626 Imputed G DOM 435 0.7689 0.1982 0.5213 1.134 −1.326 0.1849 0.3923 0.26552 0.2487 0.2782 rs16964300 Imputed G ADD 439 0.7656 0.1898 0.5278 1.111 −1.407 0.1593 0.863 0.16515 0.1455 0.18 rs16964300 Imputed G DOM 439 0.6717 0.2145 0.4411 1.023 −1.855 0.06358 0.863 0.16515 0.1455 0.18 rs16986282 Imputed G DOM 442 0.3565 0.3985 0.1632 0.7784 −2.589 0.009634 0.2362 0.04638 0.0262 0.0618 rs17007620 Imputed G ADD 408 1.033 0.1717 0.7377 1.446 0.1877 0.8511 1 0.22181 0.226 0.2186 rs17007620 Imputed G DOM 408 1.127 0.206 0.7523 1.687 0.5784 0.563 1 0.22181 0.226 0.2186 rs17014326 Imputed G DOM 441 1.215 0.196 0.8276 1.785 0.9949 0.3198 0.9106 0.30499 0.3141 0.298 rs17047957 Imputed C DOM 439 1.801 0.2129 1.187 2.734 2.765 0.005699 0.6092 0.16856 0.2063 0.14 rs1705261 Imputed A REC 442 2.005 0.2767 1.166 3.449 2.514 0.01192 0.5499 0.39367 0.4395 0.3591 rs17073341 Imputed A ADD 441 2.051 0.3685 0.9962 4.224 1.95 0.05123 0.09324 0.03515 0.05 0.0239 rs17073341 Imputed A DOM 441 2.316 0.4002 1.057 5.074 2.098 0.03591 0.09324 0.03515 0.05 0.0239 rs17138702 Imputed G ADD 443 1.127 0.1808 0.7906 1.606 0.6601 0.5092 0.1045 0.15463 0.1649 0.1468 rs17189710 Imputed T ADD 430 1.382 0.1457 1.039 1.839 2.22 0.02639 0.3369 0.34535 0.3865 0.3143 rs17189710 Imputed T GEN 430 6.752 0.03418 0.3369 0.34535 0.3865 0.3143 rs17189710 Imputed T REC 430 2.127 0.2957 1.192 3.797 2.553 0.01069 0.3369 0.34535 0.3865 0.3143 rs17310176 Imputed T ADD 443 0.6446 0.1904 0.4438 0.9362 −2.306 0.02109 0.8641 0.16704 0.1335 0.1925 rs17310176 Imputed T DOM 443 0.6022 0.2152 0.395 0.9182 −2.357 0.01845 0.8641 0.16704 0.1335 0.1925 rs17358860 Imputed A DOM 416 0.5513 0.2173 0.3601 0.844 −2.74 0.006139 0.3352 0.1887 0.1547 0.2149 rs17370541 Imputed T GEN 397 0.1403 0.9322 0.287 0.38035 0.3844 0.3772 rs17370541 Imputed T REC 397 1.119 0.3013 0.62 2.02 0.3735 0.7088 0.287 0.38035 0.3844 0.3772 rs17526574 Imputed G GEN 443 0.4224 0.8096 0.3222 0.31603 0.3063 0.3234 rs17530747 Imputed T DOM 374 1.033 0.2172 0.6751 1.582 0.1511 0.8799 0.0203 0.3369 0.3438 0.3318 rs17649114 Imputed C DOM 440 1.776 0.2066 1.185 2.663 2.781 0.00542 0.06 0.18864 0.2302 0.1574 rs17766172 Imputed A REC 428 0.5776 0.3128 0.3129 1.066 −1.755 0.07928 0.4542 0.34579 0.3242 0.3618 rs1818885 Imputed G GEN 443 0.8065 0.6682 0.7429 0.31941 0.3246 0.3155 rs1832222 Imputed G DOM 443 1.344 0.1965 0.9144 1.975 1.504 0.1325 0.2005 0.33521 0.3691 0.3095 rs1861327 Imputed G DOM 433 0.8914 0.2099 0.5908 1.345 −0.5476 0.584 0.8446 0.42494 0.3989 0.4449 rs1868581 Imputed G ADD 436 1.033 0.1486 0.7722 1.383 0.2208 0.8253 0.5814 0.31881 0.3218 0.3165 rs1868581 Imputed G GEN 436 0.5916 0.7439 0.5814 0.31881 0.3218 0.3165 rs1874313 Imputed A ADD 443 0.7883 0.1424 0.5963 1.042 −1.671 0.09473 0.6922 0.39503 0.3639 0.4187 rs1874313 Imputed A DOM 443 0.7338 0.2032 0.4927 1.093 −1.523 0.1277 0.6922 0.39503 0.3639 0.4187 rs1876409 Imputed C DOM 443 1.204 0.1943 0.8227 1.762 0.9553 0.3394 0.8255 0.31264 0.322 0.3056 rs1913201 Imputed G ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.4054 0.4899 rs1913201 Imputed G DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.4054 0.4899 rs1913201 Imputed G GEN 432 6.276 0.04338 0.438 0.4537 0.4054 0.4899 rs1916922 Imputed T GEN 435 0.5208 0.7707 0.6579 0.31724 0.3218 0.3138 rs1936871 Genotyped G DOM 443 0.7975 0.2097 0.5287 1.203 −1.079 0.2807 0.7727 0.44357 0.4346 0.4504 rs1961157 Imputed T REC 442 1.145 0.2401 0.7152 1.833 0.5643 0.5725 0.5032 0.45814 0.466 0.4522 rs1987179 Imputed T ADD 417 0.617 0.1957 0.4205 0.9055 −2.467 0.01361 0.8637 0.17266 0.1346 0.2021 rs1987179 Imputed T DOM 417 0.5176 0.2237 0.3339 0.8024 −2.944 0.00324 0.8637 0.17266 0.1346 0.2021 rs1990023 Imputed T DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.009541 0.1134 0.34312 0.3089 0.369 rs1995025 Imputed C DOM 433 1.717 0.216 1.124 2.621 2.501 0.01238 0.1894 0.15012 0.1855 0.1235 rs2016194 Imputed G DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs2023651 Imputed T ADD 429 1.235 0.1824 0.864 1.766 1.159 0.2466 0.08904 0.21911 0.2391 0.2041 rs2024902 Imputed A ADD 442 1.087 0.2583 0.655 1.803 0.3216 0.7477 0.2797 0.07353 0.0759 0.0717 rs2024902 Imputed A DOM 442 1.157 0.2804 0.6678 2.005 0.52 0.6031 0.2797 0.07353 0.0759 0.0717 rs2025107 Imputed A DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.0895 0.0913 rs2025108 Imputed T DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.0895 0.0913 rs2031987 Imputed T GEN 443 0.4224 0.8096 0.3222 0.31603 0.3063 0.3234 rs2052428 Imputed C DOM 427 0.7089 0.2176 0.4628 1.086 −1.581 0.1138 0.2452 0.47892 0.4622 0.4917 rs2053230 Imputed C ADD 391 0.8193 0.2084 0.5446 1.233 −0.9565 0.3388 6.29E−06 0.19309 0.1794 0.2036 rs2062448 Imputed T DOM 442 0.913 0.2688 0.5391 1.546 −0.3387 0.7348 0.09556 0.07692 0.0737 0.0794 rs2063420 Imputed C REC 442 0.8647 0.2574 0.5221 1.432 −0.5649 0.5721 0.2891 0.43778 0.4342 0.4405 rs2063591 Imputed C ADD 441 0.7255 0.1363 0.5554 0.9478 −2.353 0.01861 0.2947 0.47506 0.4293 0.51 rs2063591 Imputed C DOM 441 0.6936 0.2125 0.4573 1.052 −1.722 0.08515 0.2947 0.47506 0.4293 0.51 rs208026 Genotyped A DOM 443 1.559 0.1973 1.059 2.295 2.25 0.02446 0.4931 0.22348 0.2539 0.2004 rs208029 Imputed T DOM 422 1.924 0.2083 1.279 2.894 3.142 0.001679 1 0.20024 0.2432 0.1674 rs208757 Imputed G DOM 435 1.858 0.2057 1.241 2.78 3.011 0.002601 0.6456 0.19425 0.2354 0.1626 rs2095586 Imputed A DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.3355 0.33145 0.3665 0.3048 rs2095606 Imputed A DOM 436 0.9481 0.2038 0.6359 1.414 −0.2614 0.7938 0.105 0.38073 0.385 0.3775 rs2102374 Imputed A ADD 437 1.135 0.1587 0.8318 1.549 0.7991 0.4242 0.1584 0.2849 0.2974 0.2753 rs2102374 Imputed A DOM 437 1.187 0.1949 0.8099 1.739 0.8784 0.3797 0.1584 0.2849 0.2974 0.2753 rs2108426 Imputed C DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs2110664 Imputed A DOM 399 1.47 0.2058 0.9818 2.2 1.871 0.06136 1 0.27569 0.3052 0.2533 rs2132242 Imputed A ADD 440 0.7679 0.1423 0.5811 1.015 −1.856 0.06344 1 0.40341 0.3684 0.43 rs2132242 Imputed A DOM 440 0.6978 0.2022 0.4695 1.037 −1.78 0.07505 1 0.40341 0.3684 0.43 rs2158958 Imputed A DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs2158961 Imputed G DOM 443 0.6399 0.1948 0.4368 0.9373 −2.293 0.02187 0.8242 0.30813 0.2801 0.3294 rs2163046 Imputed A DOM 436 1.529 0.2 1.033 2.263 2.124 0.03363 0.8879 0.21674 0.246 0.1943 rs2180286 Imputed G DOM 443 0.587 0.2201 0.3813 0.9037 −2.42 0.01553 0.3923 0.50564 0.4712 0.5317 rs2180684 Imputed A DOM 433 1.876 0.2393 1.174 2.999 2.629 0.00857 0.3529 0.11778 0.1478 0.0951 rs2188079 Imputed C ADD 443 1.028 0.1399 0.7818 1.353 0.2006 0.841 0.563 0.43905 0.445 0.4345 rs2188079 Imputed C GEN 443 1.2 0.5489 0.563 0.43905 0.445 0.4345 rs2190598 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs2190600 Imputed A DOM 440 0.577 0.2025 0.388 0.8581 −2.716 0.006612 0.07522 0.34886 0.3132 0.376 rs2224184 Genotyped T DOM 443 0.587 0.2201 0.3813 0.9037 −2.42 0.01553 0.447 0.50451 0.4712 0.5298 rs2247066 Imputed A DOM 441 1.231 0.195 0.8402 1.804 1.067 0.2859 0.6571 0.30952 0.322 0.3 rs2248236 Imputed C ADD 443 0.6625 0.1753 0.4699 0.9342 −2.348 0.01888 0.8852 0.20655 0.1702 0.2341 rs2248236 Imputed C DOM 443 0.5404 0.2044 0.362 0.8067 −3.011 0.002602 0.8852 0.20655 0.1702 0.2341 rs2265733 Imputed C ADD 437 1.135 0.1587 0.8318 1.549 0.7991 0.4242 0.1584 0.2849 0.2974 0.2753 rs2265733 Imputed C DOM 437 1.187 0.1949 0.8099 1.739 0.8784 0.3797 0.1584 0.2849 0.2974 0.2753 rs2270584 Imputed A ADD 441 0.7517 0.1419 0.5692 0.9927 −2.011 0.04429 0.4848 0.39342 0.3553 0.4223 rs2270584 Imputed A DOM 441 0.6747 0.2026 0.4536 1.004 −1.942 0.05211 0.4848 0.39342 0.3553 0.4223 rs2270586 Imputed A ADD 442 0.7586 0.1416 0.5748 1.001 −1.952 0.05099 0.4864 0.39367 0.356 0.4223 rs2270586 Imputed A DOM 442 0.6883 0.2018 0.4634 1.022 −1.851 0.06423 0.4864 0.39367 0.356 0.4223 rs229775 Imputed A REC 443 0.6598 0.3096 0.3596 1.211 −1.343 0.1794 0.6028 0.35214 0.3429 0.3591 rs229815 Imputed T REC 432 0.6306 0.295 0.3537 1.124 −1.563 0.1181 0.4755 0.38194 0.3824 0.3816 rs229829 Imputed C REC 413 0.5855 0.2981 0.3264 1.05 −1.795 0.07258 0.7558 0.38741 0.3857 0.3887 rs229831 Imputed A REC 441 0.6194 0.315 0.3341 1.148 −1.521 0.1283 0.466 0.35261 0.3421 0.3606 rs2317057 Imputed T ADD 368 0.5936 0.1943 0.4056 0.8687 −2.685 0.007256 0.6434 0.21467 0.1687 0.2512 rs2322100 Genotyped T REC 443 2.61 0.3935 1.207 5.644 2.438 0.01477 0.7091 0.25734 0.2906 0.2321 rs2322101 Imputed A REC 440 2.67 0.3944 1.233 5.784 2.491 0.01275 0.7102 0.25909 0.2937 0.2331 rs2327929 Imputed G REC 441 1.411 0.2475 0.8684 2.291 1.39 0.1645 0.4376 0.42857 0.4476 0.414 rs2332844 Imputed A ADD 282 1.301 0.2435 0.807 2.096 1.079 0.2804 0.8232 0.8422 0.8583 0.8302 rs2332844 Imputed A REC 282 1.427 0.2711 0.8386 2.427 1.311 0.19 0.8232 0.8422 0.8583 0.8302 rs2349170 Imputed G DOM 443 1.414 0.198 0.9594 2.085 1.751 0.07997 0.06576 0.23702 0.2723 0.2103 rs2356722 Imputed G DOM 443 1.255 0.1956 0.8553 1.841 1.161 0.2457 0.8223 0.30135 0.3141 0.2917 rs2364956 Imputed T ADD 415 1.168 0.1854 0.8122 1.68 0.838 0.402 0.09486 0.15783 0.1713 0.1477 rs2373793 Imputed G ADD 435 1.56 0.1996 1.055 2.307 2.227 0.02596 1 0.14253 0.1737 0.1184 rs2373793 Imputed G DOM 435 1.599 0.2233 1.032 2.477 2.103 0.03546 1 0.14253 0.1737 0.1184 rs238252 Imputed G ADD 434 1.155 0.2029 0.7763 1.72 0.712 0.4765 1 0.13364 0.1436 0.126 rs238252 Imputed G DOM 434 1.191 0.2236 0.7681 1.846 0.7803 0.4352 1 0.13364 0.1436 0.126 rs2383903 Imputed G DOM 443 0.7568 0.1968 0.5146 1.113 −1.416 0.1569 0.4634 0.26411 0.2461 0.2778 rs2387945 Imputed G DOM 436 1.747 0.2151 1.146 2.663 2.593 0.009513 0.1892 0.15023 0.1862 0.123 rs2389863 Imputed A DOM 432 0.5655 0.2068 0.377 0.8481 −2.756 0.005845 1 0.20602 0.172 0.2317 rs2389866 Imputed C DOM 443 0.5404 0.2044 0.362 0.8067 −3.011 0.002602 0.8852 0.20655 0.1702 0.2341 rs2389869 Imputed C DOM 443 0.5404 0.2044 0.362 0.8067 −3.011 0.002602 0.8852 0.20655 0.1702 0.2341 rs2389870 Genotyped C DOM 443 0.5285 0.2176 0.345 0.8096 −2.931 0.003382 0.8641 0.16704 0.1309 0.1944 rs2418494 Imputed G ADD 423 0.6959 0.1462 0.5225 0.9268 −2.48 0.01314 0.3781 0.54137 0.4917 0.5785 rs2418494 Imputed G GEN 423 6.342 0.04195 0.3781 0.54137 0.4917 0.5785 rs2418541 Imputed A DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.009541 0.1134 0.34312 0.3089 0.369 rs2418542 Imputed A DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.009541 0.1134 0.34312 0.3089 0.369 rs2423556 Imputed C DOM 433 0.5931 0.2244 0.382 0.9206 −2.328 0.01989 0.3868 0.51155 0.4808 0.5339 rs2437688 Imputed C ADD 443 2.041 0.2367 1.284 3.247 3.014 0.002576 0.6021 0.10158 0.1361 0.0754 rs2456809 Imputed G DOM 438 1.173 0.1954 0.7998 1.721 0.8168 0.414 0.9116 0.31393 0.3218 0.308 rs2456811 Imputed T ADD 436 1.146 0.1589 0.8394 1.565 0.8588 0.3905 0.1583 0.28555 0.2989 0.2753 rs2456811 Imputed T DOM 436 1.202 0.1953 0.8198 1.763 0.9425 0.346 0.1583 0.28555 0.2989 0.2753 rs2476976 Imputed C DOM 442 1.391 0.1963 0.9466 2.044 1.68 0.09288 0.2817 0.32919 0.3639 0.3028 rs2484911 Imputed A DOM 443 1.347 0.1959 0.9174 1.977 1.52 0.1285 0.1443 0.30474 0.3403 0.2778 rs2488557 Imputed C DOM 431 0.924 0.2286 0.5904 1.446 −0.3457 0.7296 0.4009 0.12993 0.121 0.1367 rs250162 Imputed C ADD 429 0.6714 0.1771 0.4745 0.9501 −2.249 0.02451 0.0772 0.2296 0.1935 0.2572 rs250162 Imputed C DOM 429 0.6417 0.2018 0.4321 0.953 −2.199 0.02791 0.0772 0.2296 0.1935 0.2572 rs2560708 Imputed T ADD 436 0.7416 0.1846 0.5164 1.065 −1.619 0.1054 0.6189 0.17546 0.1526 0.1931 rs2617841 Imputed G DOM 412 0.7326 0.2034 0.4917 1.092 −1.53 0.1261 0.6968 0.25364 0.2386 0.2648 rs2622499 Imputed G DOM 443 0.5404 0.2044 0.362 0.8067 −3.011 0.002602 0.8852 0.20655 0.1702 0.2341 rs264129 Imputed T DOM 443 0.6399 0.1948 0.4368 0.9373 −2.293 0.02187 0.8242 0.30813 0.2801 0.3294 rs2642936 Imputed T ADD 428 0.9768 0.1833 0.682 1.399 −0.1281 0.8981 0.2772 0.19276 0.1913 0.1939 rs2660633 Imputed A DOM 443 1.204 0.1943 0.8227 1.762 0.9553 0.3394 0.8255 0.31264 0.322 0.3056 rs2660634 Imputed C DOM 443 1.204 0.1943 0.8227 1.762 0.9553 0.3394 0.8255 0.31264 0.322 0.3056 rs2660648 Imputed A ADD 437 1.135 0.1587 0.8318 1.549 0.7991 0.4242 0.1584 0.2849 0.2974 0.2753 rs2660648 Imputed A DOM 437 1.187 0.1949 0.8099 1.739 0.8784 0.3797 0.1584 0.2849 0.2974 0.2753 rs2681505 Imputed T ADD 443 0.8499 0.1719 0.6068 1.19 −0.9458 0.3442 0.493 0.22235 0.2094 0.2321 rs277411 Imputed G DOM 442 1.109 0.3436 0.5658 2.175 0.3022 0.7625 1 0.04412 0.0447 0.0437 rs2832634 Imputed G ADD 442 1.764 0.2529 1.075 2.896 2.245 0.02478 0.113 0.08484 0.1099 0.0657 rs2832637 Imputed T ADD 442 1.764 0.2529 1.075 2.896 2.245 0.02478 0.113 0.08484 0.1099 0.0657 rs2843167 Imputed A DOM 442 1.111 0.1972 0.7547 1.635 0.5327 0.5943 0.9102 0.29977 0.3037 0.2968 rs2876227 Imputed C ADD 442 1.389 0.1445 1.046 1.843 2.272 0.02309 0.4631 0.34502 0.3874 0.3127 rs2876227 Imputed C GEN 442 6.593 0.03701 0.4631 0.34502 0.3874 0.3127 rs2882097 Imputed A DOM 443 1.364 0.1959 0.9291 2.003 1.584 0.1131 0.1655 0.33409 0.3691 0.3075 rs2909862 Imputed G DOM 416 1.083 0.2178 0.7067 1.659 0.3656 0.7146 0.08505 0.40625 0.4167 0.3983 rs3001945 Imputed T DOM 435 1.72 0.2156 1.127 2.625 2.515 0.0119 0.1899 0.14943 0.1845 0.123 rs3011020 Imputed C DOM 436 1.747 0.2151 1.146 2.663 2.593 0.009513 0.1892 0.15023 0.1862 0.123 rs36071725 Genotyped C ADD 443 0.9696 0.1509 0.7214 1.303 −0.2047 0.8378 0.5846 0.31828 0.3141 0.3214 rs36071725 Genotyped C GEN 443 0.6419 0.7255 0.5846 0.31828 0.3141 0.3214 rs373983 Imputed G DOM 414 1.954 0.2168 1.277 2.988 3.089 0.002005 0.9193 0.41063 0.4536 0.3766 rs3743794 Imputed G DOM 434 0.8871 0.2078 0.5903 1.333 −0.5765 0.5643 0.6221 0.4182 0.3963 0.435 rs3756154 Imputed C ADD 416 0.6137 0.1939 0.4196 0.8975 −2.518 0.01182 1 0.17668 0.1374 0.2073 rs3756154 Imputed C DOM 416 0.5162 0.2209 0.3348 0.7959 −2.993 0.00276 1 0.17668 0.1374 0.2073 rs3775850 Imputed A DOM 443 0.5373 0.2207 0.3486 0.828 −2.816 0.004869 0.6032 0.16253 0.1283 0.1885 rs3775851 Imputed C DOM 443 0.5373 0.2207 0.3486 0.828 −2.816 0.004869 0.6032 0.16253 0.1283 0.1885 rs3793044 Imputed C ADD 443 1.091 0.2583 0.6574 1.81 0.3362 0.7367 0.279 0.07336 0.0759 0.0714 rs3793044 Imputed C DOM 443 1.162 0.2804 0.6707 2.013 0.5355 0.5923 0.279 0.07336 0.0759 0.0714 rs3793053 Imputed C DOM 436 0.9919 0.2675 0.5872 1.676 −0.03035 0.9758 0.06405 0.0883 0.0878 0.0887 rs3796246 Imputed G DOM 442 0.9829 0.2682 0.5811 1.663 −0.06425 0.9488 0.5013 0.07805 0.0759 0.0797 rs3806003 Imputed A ADD 443 1.091 0.2583 0.6574 1.81 0.3362 0.7367 0.279 0.07336 0.0759 0.0714 rs3806003 Imputed A DOM 443 1.162 0.2804 0.6707 2.013 0.5355 0.5923 0.279 0.07336 0.0759 0.0714 rs3806004 Imputed T DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.0895 0.0913 rs3806010 Imputed T DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.0895 0.0913 rs3806014 Imputed T DOM 430 1.002 0.2658 0.5954 1.688 0.00889 0.9929 0.06876 0.0907 0.0902 0.0911 rs3806015 Imputed A DOM 426 0.9945 0.2663 0.5902 1.676 −0.02059 0.9836 0.07007 0.09155 0.0907 0.0922 rs3806018 Imputed A DOM 442 0.982 0.2619 0.5877 1.641 −0.06944 0.9446 0.0729 0.0905 0.0895 0.0913 rs3806019 Imputed A DOM 438 0.9676 0.2625 0.5784 1.619 −0.1255 0.9001 0.07445 0.09132 0.0899 0.0924 rs3806024 Imputed T DOM 442 1.001 0.2605 0.601 1.669 0.00521 0.9958 0.03996 0.09276 0.0942 0.0916 rs3915080 Imputed A GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs3942254 Imputed T ADD 420 0.7577 0.1442 0.5712 1.005 −1.925 0.05425 0.1836 0.39167 0.3539 0.4194 rs3942254 Imputed T DOM 420 0.6591 0.2081 0.4383 0.991 −2.004 0.04512 0.1836 0.39167 0.3539 0.4194 rs3945085 Imputed A DOM 441 1.324 0.1969 0.9003 1.948 1.427 0.1537 0.05672 0.34014 0.3743 0.314 rs3976737 Imputed G ADD 377 1.239 0.1939 0.8469 1.811 1.103 0.27 0.4634 0.16976 0.1867 0.1575 rs399485 Imputed A DOM 437 1.648 0.1968 1.12 2.423 2.538 0.01116 0.3195 0.25973 0.2921 0.2348 rs4029119 Imputed G ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.0734 rs4029119 Imputed G DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.0734 rs4076201 Imputed G GEN 420 2.573 0.2762 0.7866 0.23452 0.2527 0.2203 rs4076201 Imputed G REC 420 1.982 0.4368 0.842 4.666 1.566 0.1173 0.7866 0.23452 0.2527 0.2203 rs41395945 Imputed G ADD 441 1.822 0.2555 1.104 3.006 2.348 0.01887 0.1081 0.0839 0.1099 0.064 rs41395945 Imputed G DOM 441 1.919 0.2846 1.099 3.352 2.29 0.022 0.1081 0.0839 0.1099 0.064 rs4146972 Genotyped T DOM 443 1.832 0.2123 1.208 2.777 2.851 0.004361 0.7362 0.17043 0.2094 0.1409 rs4238087 Imputed G DOM 402 0.5579 0.251 0.3411 0.9125 −2.325 0.02009 0.4923 0.12562 0.1 0.1444 rs4251569 Imputed T ADD 441 0.645 0.2176 0.4211 0.9882 −2.015 0.04394 0.4959 0.12018 0.0942 0.14 rs4251569 Imputed T DOM 441 0.5571 0.243 0.346 0.897 −2.407 0.01607 0.4959 0.12018 0.0942 0.14 rs4273613 Imputed T ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.0734 rs4273613 Imputed T DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.0734 rs4291049 Imputed T REC 432 1.16 0.2386 0.727 1.852 0.6237 0.5328 1 0.46065 0.4565 0.4637 rs4315598 Imputed T ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.3874 0.3115 rs4315598 Imputed T GEN 443 6.692 0.03523 0.2479 0.34424 0.3874 0.3115 rs4315598 Imputed T REC 443 2.069 0.2898 1.172 3.65 2.508 0.01214 0.2479 0.34424 0.3874 0.3115 rs4321395 Imputed A DOM 408 1.094 0.2214 0.7089 1.689 0.4062 0.6846 0.2701 0.4424 0.4454 0.4402 rs4321596 Genotyped T REC 443 2.583 0.4532 1.063 6.278 2.094 0.03627 0.3429 0.22573 0.2565 0.2024 rs4324417 Imputed T DOM 443 1.061 0.217 0.6932 1.623 0.2716 0.7859 0.08691 0.48646 0.5026 0.4742 rs4328619 Genotyped G DOM 443 0.5613 0.2195 0.365 0.8631 −2.631 0.008525 1 0.44018 0.4188 0.4563 rs4338909 Imputed T ADD 440 0.998 0.1323 0.7701 1.293 −0.01507 0.988 0.06541 0.43295 0.4339 0.4323 rs4370878 Imputed G DOM 440 1.312 0.1971 0.8916 1.931 1.378 0.1682 0.1648 0.33523 0.3684 0.31 rs4379434 Genotyped T DOM 443 0.9929 0.2031 0.6669 1.478 −0.03512 0.972 0.2061 0.42099 0.4267 0.4167 rs4416407 Imputed T DOM 437 1.387 0.2325 0.8796 2.188 1.408 0.1591 0.00049 0.55149 0.5824 0.5281 rs4417899 Imputed C REC 437 0.7208 0.2325 0.457 1.137 −1.408 0.1591 0.00049 0.44851 0.4176 0.4719 rs4442732 Imputed A ADD 335 0.9155 0.1782 0.6456 1.298 −0.4952 0.6205 0.1439 0.3403 0.3333 0.3452 rs4444612 Imputed G ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.3874 0.3115 rs4444612 Imputed G GEN 443 6.692 0.03523 0.2479 0.34424 0.3874 0.3115 rs4444612 Imputed G REC 443 2.069 0.2898 1.172 3.65 2.508 0.01214 0.2479 0.34424 0.3874 0.3115 rs4450660 Imputed C DOM 438 1.275 0.1965 0.8675 1.874 1.236 0.2163 0.378 0.25457 0.2632 0.248 rs4509702 Imputed C DOM 440 1.312 0.1971 0.8916 1.931 1.378 0.1682 0.1648 0.33523 0.3684 0.31 rs4526920 Imputed G GEN 443 0.4224 0.8096 0.3222 0.31603 0.3063 0.3234 rs4533145 Imputed T DOM 441 1.764 0.2281 1.128 2.759 2.489 0.0128 0.6582 0.12358 0.1534 0.1012 rs4557006 Imputed A DOM 401 1.096 0.2227 0.7085 1.696 0.4124 0.6801 0.3625 0.44389 0.4454 0.4427 rs4570530 Imputed C DOM 440 1.312 0.1971 0.8916 1.931 1.378 0.1682 0.1648 0.33523 0.3684 0.31 rs4615971 Imputed C DOM 440 1.347 0.1965 0.9164 1.98 1.516 0.1296 0.2375 0.33182 0.3658 0.306 rs4628119 Imputed A DOM 442 1.055 0.1992 0.7139 1.559 0.268 0.7887 0.3439 0.22624 0.2251 0.2271 rs4664443 Imputed G ADD 442 1.009 0.1374 0.7712 1.321 0.06836 0.9455 0.2878 0.43891 0.4398 0.4382 rs4688259 Imputed T DOM 438 1.386 0.2325 0.8791 2.187 1.405 0.1599 0.0007 0.55137 0.5824 0.528 rs4688632 Imputed G REC 429 0.6822 0.2335 0.4316 1.078 −1.638 0.1014 0.00063 0.45338 0.4189 0.4795 rs4695284 Imputed A ADD 194 1.444 0.3862 0.6775 3.079 0.9518 0.3412 1 0.08763 0.1053 0.0763 rs4700302 Imputed A ADD 399 1.136 0.2485 0.6982 1.85 0.5147 0.6067 1 0.09398 0.1012 0.0885 rs4702720 Imputed A ADD 359 0.757 0.1808 0.5311 1.079 −1.54 0.1236 1 0.24652 0.2194 0.2672 rs4702720 Imputed A DOM 359 0.6462 0.2205 0.4194 0.9956 −1.98 0.04769 1 0.24652 0.2194 0.2672 rs4711091 Genotyped G GEN 443 1.334 0.5133 0.634 0.47743 0.4607 0.4901 rs4714484 Imputed A ADD 439 0.8396 0.1992 0.5682 1.241 −0.8775 0.3802 0.3702 0.15718 0.1455 0.166 rs4736802 Imputed G DOM 442 0.9844 0.2032 0.661 1.466 −0.07725 0.9384 0.2044 0.42081 0.4263 0.4167 rs4760785 Imputed A ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.4054 0.4899 rs4760785 Imputed A DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.4054 0.4899 rs4760785 Imputed A GEN 432 6.276 0.04338 0.438 0.4537 0.4054 0.4899 rs4760894 Imputed T ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.4054 0.4899 rs4760894 Imputed T DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.4054 0.4899 rs4760894 Imputed T GEN 432 6.276 0.04338 0.438 0.4537 0.4054 0.4899 rs4760895 Imputed A ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.4054 0.4899 rs4760895 Imputed A DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.4054 0.4899 rs4760895 Imputed A GEN 432 6.276 0.04338 0.438 0.4537 0.4054 0.4899 rs4764738 Imputed A ADD 430 0.9549 0.142 0.723 1.261 −0.3248 0.7454 0.699 0.53488 0.5294 0.5391 rs4764738 Imputed A GEN 430 0.6545 0.7209 0.699 0.53488 0.5294 0.5391 rs4764974 Imputed T ADD 431 0.9019 0.1389 0.6869 1.184 −0.7436 0.4571 0.9232 0.5058 0.4892 0.5183 rs4764974 Imputed T GEN 431 0.568 0.7528 0.9232 0.5058 0.4892 0.5183 rs4798366 Imputed G REC 429 2.754 0.3596 1.361 5.574 2.817 0.004844 0.9088 0.30186 0.3289 0.281 rs483159 Imputed T DOM 386 1.953 0.219 1.271 2.999 3.056 0.002245 0.3957 0.18264 0.2256 0.1509 rs4836502 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs4836507 Imputed C DOM 442 0.5803 0.2019 0.3906 0.862 −2.696 0.007028 0.09482 0.34955 0.3141 0.3765 rs4836744 Imputed A ADD 443 0.7176 0.155 0.5296 0.9724 −2.141 0.03229 0.5022 0.30587 0.267 0.3353 rs4836744 Imputed A DOM 443 0.6515 0.1952 0.4444 0.9552 −2.195 0.02818 0.5022 0.30587 0.267 0.3353 rs4848944 Genotyped C REC 443 0.7027 0.2417 0.4375 1.128 −1.46 0.1443 1 0.46501 0.4162 0.502 rs4851529 Imputed A DOM 442 0.6342 0.203 0.426 0.944 −2.244 0.02485 0.3797 0.42081 0.3868 0.4464 rs4851531 Imputed T DOM 442 0.6071 0.2055 0.4058 0.9082 −2.428 0.01517 0.2107 0.44231 0.4005 0.4741 rs4858046 Genotyped T GEN 443 1.33 0.5142 0.9151 0.33409 0.3429 0.3274 rs4878214 Imputed A ADD 261 0.7554 0.1893 0.5212 1.095 −1.481 0.1385 0.01259 0.3046 0.2672 0.3345 rs4880803 Imputed A ADD 439 0.6594 0.1519 0.4896 0.888 −2.742 0.006112 0.578 0.31093 0.2605 0.3494 rs489441 Imputed G ADD 409 1.224 0.1644 0.8866 1.689 1.228 0.2195 0.6152 0.26773 0.2874 0.2532 rs489441 Imputed G DOM 409 1.384 0.2043 0.9276 2.066 1.592 0.1114 0.6152 0.26773 0.2874 0.2532 rs4896568 Imputed T DOM 410 1.056 0.2054 0.7057 1.579 0.2631 0.7925 0.3356 0.23415 0.233 0.235 rs4938851 Imputed T DOM 443 1.781 0.2035 1.195 2.654 2.835 0.004584 0.05052 0.19752 0.2408 0.1647 rs4964416 Imputed C DOM 443 0.6905 0.2178 0.4506 1.058 −1.701 0.08902 0.3418 0.49323 0.4817 0.502 rs5756669 Imputed C DOM 443 1.061 0.217 0.6932 1.623 0.2716 0.7859 0.08691 0.48646 0.5026 0.4742 rs6033138 Imputed C ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.3874 0.3115 rs6033138 Imputed C GEN 443 6.692 0.03523 0.2479 0.34424 0.3874 0.3115 rs6033138 Imputed C REC 443 2.069 0.2898 1.172 3.65 2.508 0.01214 0.2479 0.34424 0.3874 0.3115 rs6040619 Imputed C ADD 439 1.429 0.1436 1.079 1.894 2.487 0.01287 0.3441 0.34852 0.3963 0.3127 rs6040619 Imputed C GEN 439 7.276 0.02631 0.3441 0.34852 0.3963 0.3127 rs6040619 Imputed C REC 439 2.094 0.2899 1.186 3.695 2.549 0.01081 0.3441 0.34852 0.3963 0.3127 rs6040625 Imputed T ADD 442 1.414 0.1431 1.068 1.871 2.419 0.01557 0.3449 0.34729 0.3927 0.3127 rs6040625 Imputed T GEN 442 6.967 0.0307 0.3449 0.34729 0.3927 0.3127 rs6040625 Imputed T REC 442 2.067 0.2898 1.171 3.646 2.505 0.01224 0.3449 0.34729 0.3927 0.3127 rs6040630 Imputed A ADD 441 1.401 0.1436 1.058 1.857 2.349 0.01881 0.2464 0.34467 0.3895 0.3108 rs6040630 Imputed A GEN 441 6.767 0.03392 0.2464 0.34467 0.3895 0.3108 rs6040630 Imputed A REC 441 2.062 0.2897 1.168 3.637 2.497 0.01252 0.2464 0.34467 0.3895 0.3108 rs6040633 Imputed A ADD 442 1.391 0.1433 1.05 1.842 2.302 0.02133 0.2489 0.34502 0.3895 0.3115 rs6040633 Imputed A GEN 442 6.683 0.03539 0.2489 0.34502 0.3895 0.3115 rs6040633 Imputed A REC 442 2.063 0.2897 1.169 3.641 2.5 0.01242 0.2489 0.34502 0.3895 0.3115 rs6040634 Imputed T ADD 441 1.404 0.1433 1.06 1.859 2.368 0.01791 0.295 0.34694 0.3921 0.3127 rs6040634 Imputed T GEN 441 6.855 0.03246 0.295 0.34694 0.3921 0.3127 rs6040634 Imputed T REC 441 2.069 0.2898 1.173 3.652 2.509 0.0121 0.295 0.34694 0.3921 0.3127 rs6040636 Imputed T ADD 443 1.371 0.1435 1.034 1.816 2.196 0.0281 0.2458 0.34312 0.3848 0.3115 rs6040636 Imputed T GEN 443 6.529 0.03821 0.2458 0.34312 0.3848 0.3115 rs6040636 Imputed T REC 443 2.069 0.2898 1.172 3.65 2.508 0.01214 0.2458 0.34312 0.3848 0.3115 rs6040638 Imputed C ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.3874 0.3115 rs6040638 Imputed C GEN 443 6.692 0.03523 0.2479 0.34424 0.3874 0.3115 rs6040638 Imputed C REC 443 2.069 0.2898 1.172 3.65 2.508 0.01214 0.2479 0.34424 0.3874 0.3115 rs6040644 Imputed A ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.3874 0.3115 rs6040644 Imputed A GEN 443 6.692 0.03523 0.2479 0.34424 0.3874 0.3115 rs6040644 Imputed A REC 443 2.069 0.2898 1.172 3.65 2.508 0.01214 0.2479 0.34424 0.3874 0.3115 rs6040667 Imputed T ADD 424 1.422 0.1447 1.071 1.888 2.432 0.01502 0.3997 0.35731 0.4038 0.3223 rs6040667 Imputed T GEN 424 7.201 0.02731 0.3997 0.35731 0.4038 0.3223 rs6040667 Imputed T REC 424 2.108 0.2894 1.195 3.717 2.576 0.009982 0.3997 0.35731 0.4038 0.3223 rs6040668 Imputed C ADD 440 1.398 0.1448 1.053 1.857 2.314 0.02064 0.5278 0.34659 0.3895 0.314 rs6040668 Imputed C GEN 440 6.796 0.03345 0.5278 0.34659 0.3895 0.314 rs6040668 Imputed C REC 440 2.097 0.2944 1.178 3.735 2.516 0.01186 0.5278 0.34659 0.3895 0.314 rs6043066 Genotyped G DOM 443 1.485 0.2038 0.9963 2.215 1.942 0.05215 0.6163 0.25282 0.2749 0.2361 rs6048146 Imputed G DOM 443 2.548 0.4417 1.072 6.055 2.117 0.03423 0.128 0.03837 0.0497 0.0298 rs6082725 Genotyped T DOM 443 2.548 0.4417 1.072 6.055 2.117 0.03423 0.128 0.03837 0.0497 0.0298 rs6131206 Imputed C ADD 424 1.493 0.1554 1.101 2.025 2.581 0.009855 0.2791 0.28066 0.3288 0.2438 rs6131208 Imputed T ADD 440 1.387 0.1445 1.045 1.841 2.263 0.02364 0.2909 0.34091 0.3836 0.3088 rs6131208 Imputed T GEN 440 6.748 0.03426 0.2909 0.34091 0.3836 0.3088 rs6131208 Imputed T REC 440 2.109 0.2945 1.184 3.756 2.534 0.01129 0.2909 0.34091 0.3836 0.3088 rs6134243 Imputed C ADD 443 1.389 0.1433 1.049 1.839 2.291 0.02197 0.2479 0.34424 0.3874 0.3115 rs6134243 Imputed C GEN 443 6.692 0.03523 0.2479 0.34424 0.3874 0.3115 rs6134243 Imputed C REC 443 2.069 0.2898 1.172 3.65 2.508 0.01214 0.2479 0.34424 0.3874 0.3115 rs6136020 Imputed A DOM 441 1.061 0.2134 0.6982 1.612 0.2765 0.7822 0.1646 0.1644 0.1702 0.16 rs613799 Imputed C DOM 420 1.391 0.2013 0.9378 2.065 1.641 0.1008 0.1798 0.32262 0.3591 0.295 rs644041 Imputed G ADD 402 1.202 0.1659 0.8685 1.664 1.111 0.2667 0.6136 0.27114 0.2895 0.2576 rs644041 Imputed G DOM 402 1.351 0.2068 0.9007 2.026 1.454 0.1459 0.6136 0.27114 0.2895 0.2576 rs647645 Imputed C ADD 441 0.9195 0.1447 0.6925 1.221 −0.5801 0.5619 0.6983 0.43537 0.4237 0.4442 rs647645 Imputed C GEN 441 2.764 0.2511 0.6983 0.43537 0.4237 0.4442 rs647645 Imputed C REC 441 1.143 0.2499 0.7005 1.866 0.5357 0.5922 0.6983 0.43537 0.4237 0.4442 rs6495554 Imputed C GEN 443 2.593 0.2734 0.5733 0.21332 0.2356 0.1964 rs6495554 Imputed C REC 443 1.965 0.4472 0.8177 4.72 1.51 0.1311 0.5733 0.21332 0.2356 0.1964 rs6495555 Imputed C GEN 443 2.593 0.2734 0.5733 0.21332 0.2356 0.1964 rs6495555 Imputed C REC 443 1.965 0.4472 0.8177 4.72 1.51 0.1311 0.5733 0.21332 0.2356 0.1964 rs6544728 Imputed T DOM 439 1.333 0.197 0.9058 1.961 1.458 0.1448 0.7087 0.25854 0.2686 0.251 rs6550705 Imputed C ADD 443 1.048 0.1481 0.7837 1.401 0.3148 0.7529 0.7429 0.31941 0.3246 0.3155 rs6550705 Imputed C GEN 443 0.8065 0.6682 0.7429 0.31941 0.3246 0.3155 rs6550707 Imputed T GEN 442 1.263 0.5317 0.9152 0.33484 0.3429 0.3287 rs658108 Imputed A DOM 443 1.347 0.1959 0.9174 1.977 1.52 0.1285 0.1443 0.30474 0.3403 0.2778 rs6593441 Imputed A DOM 412 1.402 0.2318 0.89 2.208 1.457 0.1451 0.1752 0.12621 0.1397 0.1159 rs668732 Imputed A DOM 442 0.9925 0.2194 0.6457 1.526 −0.0343 0.9726 0.2955 0.47738 0.4895 0.4681 rs671041 Imputed A DOM 443 1.347 0.1959 0.9174 1.977 1.52 0.1285 0.1443 0.30474 0.3403 0.2778 rs6719700 Imputed A ADD 434 1.378 0.1747 0.9785 1.941 1.836 0.06643 0.6439 0.19355 0.2222 0.1714 rs6719700 Imputed A DOM 434 1.551 0.207 1.034 2.327 2.121 0.03391 0.6439 0.19355 0.2222 0.1714 rs6722640 Imputed T DOM 441 0.5987 0.207 0.399 0.8983 −2.478 0.01322 0.2486 0.44671 0.4058 0.478 rs6743092 Imputed T ADD 434 1.239 0.1411 0.9401 1.634 1.522 0.128 1 0.5023 0.5294 0.4818 rs6743092 Imputed T GEN 434 9.618 0.008155 1 0.5023 0.5294 0.4818 rs6743092 Imputed T REC 434 1.9 0.2284 1.214 2.973 2.809 0.004962 1 0.5023 0.5294 0.4818 rs6744759 Imputed G REC 436 2.691 0.3293 1.411 5.132 3.006 0.002648 0.7394 0.31537 0.359 0.2823 rs6746170 Imputed A DOM 442 1.346 0.196 0.9168 1.977 1.517 0.1293 0.8072 0.26471 0.2775 0.255 rs6759922 Imputed A DOM 408 1.094 0.2214 0.7089 1.689 0.4062 0.6846 0.2701 0.4424 0.4454 0.4402 rs6769864 Imputed T GEN 436 1.045 0.5932 0.7436 0.32339 0.3316 0.3173 rs6773932 Imputed C GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs6774353 Imputed A GEN 443 0.8065 0.6682 0.7429 0.31941 0.3246 0.3155 rs6781670 Imputed C GEN 443 0.308 0.8573 0.5114 0.31828 0.322 0.3155 rs6786431 Imputed A GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs6789091 Imputed T GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs6791296 Imputed T ADD 426 0.6456 0.2242 0.416 1.002 −1.952 0.05092 0.08628 0.13146 0.1056 0.1504 rs6792662 Imputed G DOM 434 1.389 0.2326 0.8802 2.191 1.411 0.1581 0.00046 0.55069 0.5829 0.5263 rs6797574 Imputed G GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs6797882 Imputed G GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs6805139 Imputed G DOM 442 1.417 0.2237 0.9138 2.197 1.557 0.1194 0.00028 0.52941 0.5628 0.504 rs6806043 Imputed C ADD 441 1.05 0.1481 0.7851 1.403 0.3265 0.744 0.6626 0.31973 0.3246 0.316 rs6806043 Imputed C GEN 441 0.8672 0.6482 0.6626 0.31973 0.3246 0.316 rs6850716 Imputed C GEN 443 1.373 0.5034 0.8929 0.22912 0.2094 0.244 rs6867153 Imputed A REC 434 1.201 0.2381 0.7533 1.916 0.7701 0.4412 0.923 0.45853 0.4545 0.4615 rs687047 Imputed C ADD 443 0.5642 0.2311 0.3587 0.8876 −2.476 0.01329 0.8186 0.11512 0.0838 0.1389 rs6871041 Imputed G DOM 418 0.6503 0.2006 0.4389 0.9635 −2.145 0.03192 0.6303 0.2823 0.2582 0.3008 rs688358 Imputed A ADD 427 0.5756 0.2319 0.3653 0.9068 −2.382 0.01723 0.8183 0.1171 0.086 0.1411 rs6888012 Imputed A REC 432 1.203 0.2383 0.7542 1.919 0.7764 0.4375 0.9228 0.45949 0.457 0.4614 rs6908481 Imputed C REC 400 1.391 0.2704 0.8186 2.363 1.22 0.2226 0.7579 0.41875 0.4327 0.4083 rs7032231 Imputed A ADD 423 1.514 0.148 1.133 2.023 2.802 0.005072 0.09405 0.32033 0.3736 0.2801 rs7067638 Imputed T DOM 442 1.413 0.2274 0.905 2.207 1.521 0.1283 0.1751 0.11991 0.1342 0.1091 rs7077799 Imputed A DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.1663 0.33484 0.3691 0.3088 rs7082163 Imputed A ADD 440 1.236 0.2162 0.809 1.888 0.9797 0.3273 0.49 0.11818 0.1303 0.1091 rs7082163 Imputed A DOM 440 1.386 0.2298 0.8837 2.175 1.422 0.1551 0.49 0.11818 0.1303 0.1091 rs7089661 Imputed C DOM 442 1.347 0.1964 0.9168 1.98 1.518 0.129 0.3355 0.33145 0.3665 0.3048 rs7101319 Imputed C ADD 431 1.259 0.2167 0.8235 1.926 1.064 0.2873 0.3713 0.12065 0.1344 0.1102 rs7101319 Imputed C DOM 431 1.425 0.2303 0.9076 2.239 1.539 0.1238 0.3713 0.12065 0.1344 0.1102 rs710832 Genotyped A GEN 443 3.803 0.1494 0.4404 0.24492 0.2147 0.2679 rs710832 Genotyped A REC 443 0.4518 0.4871 0.1739 1.174 −1.631 0.1029 0.4404 0.24492 0.2147 0.2679 rs7134262 Imputed T GEN 438 5.456 0.06536 1 0.3379 0.3763 0.3085 rs7134262 Imputed T REC 438 1.986 0.3091 1.084 3.641 2.22 0.02641 1 0.3379 0.3763 0.3085 rs7134671 Imputed T GEN 443 1.45 0.4843 1 0.38939 0.4058 0.377 rs7138300 Imputed C ADD 432 0.7137 0.1396 0.5429 0.9384 −2.415 0.01572 0.438 0.4537 0.4054 0.4899 rs7138300 Imputed C DOM 432 0.7026 0.2117 0.464 1.064 −1.667 0.09546 0.438 0.4537 0.4054 0.4899 rs7138300 Imputed C GEN 432 6.276 0.04338 0.438 0.4537 0.4054 0.4899 rs7163931 Imputed G GEN 443 2.593 0.2734 0.5733 0.21332 0.2356 0.1964 rs7163931 Imputed G REC 443 1.965 0.4472 0.8177 4.72 1.51 0.1311 0.5733 0.21332 0.2356 0.1964 rs7171486 Genotyped G DOM 443 0.591 0.1997 0.3996 0.8741 −2.634 0.008445 0.7558 0.35553 0.2984 0.3988 rs7172611 Imputed G GEN 443 2.593 0.2734 0.5733 0.21332 0.2356 0.1964 rs7172611 Imputed G REC 443 1.965 0.4472 0.8177 4.72 1.51 0.1311 0.5733 0.21332 0.2356 0.1964 rs7172689 Imputed T GEN 443 2.593 0.2734 0.5733 0.21332 0.2356 0.1964 rs7172689 Imputed T REC 443 1.965 0.4472 0.8177 4.72 1.51 0.1311 0.5733 0.21332 0.2356 0.1964 rs7175701 Imputed C GEN 440 2.427 0.2972 1 0.23409 0.254 0.2191 rs7180245 Imputed A GEN 443 2.593 0.2734 0.5733 0.21332 0.2356 0.1964 rs7180245 Imputed A REC 443 1.965 0.4472 0.8177 4.72 1.51 0.1311 0.5733 0.21332 0.2356 0.1964 rs7220603 Genotyped A ADD 443 1.419 0.1547 1.048 1.921 2.261 0.02374 0.3685 0.30135 0.3403 0.2718 rs7282518 Imputed T ADD 387 1.054 0.205 0.7055 1.576 0.2585 0.796 0.7019 0.15504 0.1605 0.1511 rs7283476 Imputed T ADD 441 0.413 0.3729 0.1989 0.8579 −2.371 0.01774 0.237 0.04649 0.0262 0.062 rs7283476 Imputed T DOM 441 0.3545 0.3985 0.1623 0.7741 −2.602 0.009257 0.237 0.04649 0.0262 0.062 rs7295817 Imputed C GEN 424 6.629 0.03635 1 0.42807 0.3819 0.4628 rs7298255 Imputed A ADD 443 0.7433 0.1356 0.5699 0.9696 −2.188 0.02869 0.2143 0.46163 0.4188 0.494 rs7298255 Imputed A DOM 443 0.74 0.2089 0.4914 1.114 −1.442 0.1493 0.2143 0.46163 0.4188 0.494 rs7305832 Imputed C GEN 442 5.607 0.06061 1 0.33597 0.3743 0.3068 rs7305832 Imputed C REC 442 2.008 0.3089 1.096 3.678 2.256 0.02404 1 0.33597 0.3743 0.3068 rs7331467 Imputed A GEN 443 1.596 0.4502 1 0.34876 0.3325 0.3611 rs7392620 Imputed C ADD 437 0.6521 0.1533 0.4829 0.8807 −2.789 0.005287 0.7378 0.31121 0.2593 0.3508 rs742827 Imputed A ADD 437 1.396 0.145 1.051 1.855 2.3 0.02146 0.4608 0.34668 0.3895 0.3138 rs742827 Imputed A GEN 437 6.499 0.03879 0.4608 0.34668 0.3895 0.3138 rs742827 Imputed A REC 437 2.051 0.2943 1.152 3.652 2.441 0.01464 0.4608 0.34668 0.3895 0.3138 rs7446891 Imputed G DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs7448641 Imputed C ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.0734 rs7448641 Imputed C DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.0734 rs7484728 Imputed T GEN 443 1.45 0.4843 1 0.38939 0.4058 0.377 rs7499402 Genotyped A ADD 443 2.08 0.2847 1.191 3.634 2.573 0.01008 1 0.06546 0.089 0.0476 rs7529851 Imputed A ADD 401 0.7324 0.1517 0.544 0.986 −2.053 0.04006 0.3514 0.40648 0.3571 0.4421 rs7529851 Imputed A GEN 401 4.232 0.1205 0.3514 0.40648 0.3571 0.4421 rs7573951 Imputed G ADD 442 1.009 0.1374 0.7712 1.321 0.06836 0.9455 0.2878 0.43891 0.4398 0.4382 rs7599198 Imputed T DOM 371 0.9895 0.2386 0.6199 1.579 −0.04427 0.9647 0.1175 0.46092 0.4565 0.4643 rs7600050 Imputed C ADD 416 1.316 0.1481 0.9845 1.759 1.855 0.06365 0.9138 0.34736 0.3812 0.3213 rs7607712 Imputed T ADD 441 1.357 0.1708 0.9708 1.897 1.787 0.074 0.6555 0.19955 0.2277 0.178 rs7607712 Imputed T DOM 441 1.496 0.2035 1.004 2.23 1.98 0.04765 0.6555 0.19955 0.2277 0.178 rs7613492 Imputed G GEN 443 0.8065 0.6682 0.7429 0.31941 0.3246 0.3155 rs7621663 Imputed G ADD 443 1.048 0.1481 0.7837 1.401 0.3148 0.7529 0.7429 0.31941 0.3246 0.3155 rs7621663 Imputed G GEN 443 0.8065 0.6682 0.7429 0.31941 0.3246 0.3155 rs7621663 Imputed G REC 443 0.8874 0.3167 0.4771 1.651 −0.3773 0.706 0.7429 0.31941 0.3246 0.3155 rs7626584 Imputed G ADD 442 0.6617 0.3179 0.3549 1.234 −1.299 0.1939 1 0.05769 0.0471 0.0657 rs7684899 Imputed C ADD 417 0.617 0.1957 0.4205 0.9055 −2.467 0.01361 0.8637 0.17266 0.1346 0.2021 rs7684899 Imputed C DOM 417 0.5176 0.2237 0.3339 0.8024 −2.944 0.00324 0.8637 0.17266 0.1346 0.2021 rs7701604 Imputed G ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.0734 rs7701604 Imputed G DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.0734 rs7703676 Imputed C ADD 443 0.9741 0.2886 0.5532 1.715 −0.09096 0.9275 2.36E−05 0.07336 0.0733 0.0734 rs7703676 Imputed C DOM 443 1.136 0.3415 0.5817 2.218 0.3732 0.709 2.36E−05 0.07336 0.0733 0.0734 rs7708491 Imputed C REC 435 1.179 0.2374 0.7405 1.878 0.6947 0.4872 0.8472 0.45977 0.4545 0.4637 rs7711358 Imputed A DOM 443 0.593 0.2016 0.3994 0.8804 −2.592 0.009541 0.1134 0.34312 0.3089 0.369 rs7719448 Imputed G REC 436 1.235 0.2366 0.777 1.965 0.8936 0.3715 0.847 0.45872 0.4574 0.4597 rs7724761 Imputed T REC 435 1.207 0.2381 0.7571 1.925 0.791 0.429 0.9232 0.45862 0.4545 0.4617 rs7742476 Imputed T DOM 386 1.23 0.2098 0.8155 1.856 0.988 0.3231 0.00424 0.23316 0.2544 0.2166 rs7762993 Imputed A ADD 431 1.066 0.1948 0.7276 1.561 0.3271 0.7436 0.00187 0.18213 0.1855 0.1796 rs7762993 Imputed A DOM 431 1.079 0.2057 0.7207 1.614 0.3676 0.7132 0.00187 0.18213 0.1855 0.1796 rs7767265 Imputed G ADD 430 1.18 0.1729 0.8411 1.656 0.9587 0.3377 0.0128 0.24419 0.2594 0.2325 rs7767265 Imputed G DOM 430 1.155 0.1977 0.7839 1.702 0.7283 0.4664 0.0128 0.24419 0.2594 0.2325 rs7768128 Imputed G REC 439 0.3066 0.5174 0.1112 0.8451 −2.285 0.0223 0.7859 0.22779 0.2275 0.228 rs7771264 Imputed T DOM 441 1.051 0.1977 0.7133 1.548 0.251 0.8018 0.25 0.2483 0.2513 0.246 rs7773151 Genotyped C DOM 443 1.038 0.1992 0.7027 1.534 0.1891 0.85 0.3391 0.2246 0.2225 0.2262 rs7773210 Genotyped A DOM 443 1.038 0.1992 0.7027 1.534 0.1891 0.85 0.3391 0.2246 0.2225 0.2262 rs7808536 Imputed G DOM 409 1.374 0.2138 0.904 2.09 1.488 0.1368 0.7448 0.18582 0.2095 0.1674 rs7843510 Genotyped G DOM 443 0.9929 0.2031 0.6669 1.478 −0.03512 0.972 0.1444 0.42325 0.4293 0.4187 rs7894867 Imputed T DOM 441 1.426 0.2276 0.9129 2.228 1.559 0.1189 0.1751 0.12018 0.1349 0.1091 rs7921834 Imputed C DOM 440 1.347 0.1965 0.9164 1.98 1.516 0.1296 0.2375 0.33182 0.3658 0.306 rs7939893 Imputed C ADD 441 0.6916 0.1478 0.5177 0.924 −2.495 0.01261 0.3875 0.32653 0.2789 0.3625 rs7939893 Imputed C DOM 441 0.506 0.1982 0.3431 0.7463 −3.437 0.000589 0.3875 0.32653 0.2789 0.3625 rs7944513 Imputed T GEN 418 4.036 0.1329 0.145 0.24522 0.2793 0.2197 rs7944513 Imputed T REC 418 1.787 0.3844 0.8411 3.795 1.51 0.1311 0.145 0.24522 0.2793 0.2197 rs7949720 Imputed G ADD 418 1.485 0.2216 0.9616 2.292 1.783 0.07457 1 0.11603 0.1378 0.0987 rs7949720 Imputed G DOM 418 1.52 0.2398 0.9502 2.433 1.747 0.08065 1 0.11603 0.1378 0.0987 rs7955901 Imputed C ADD 440 0.7285 0.1367 0.5573 0.9524 −2.316 0.02054 0.2142 0.46364 0.4184 0.498 rs7955901 Imputed C DOM 440 0.7139 0.2105 0.4726 1.078 −1.601 0.1093 0.2142 0.46364 0.4184 0.498 rs7956274 Imputed T ADD 426 0.7156 0.1398 0.5441 0.9412 −2.394 0.01667 0.3288 0.45423 0.4066 0.4898 rs7956274 Imputed T DOM 426 0.7031 0.2129 0.4633 1.067 −1.655 0.098 0.3288 0.45423 0.4066 0.4898 rs7956274 Imputed T GEN 426 6.165 0.04584 0.3288 0.45423 0.4066 0.4898 rs7957932 Imputed G ADD 439 0.7234 0.1368 0.5533 0.9459 −2.366 0.01797 0.3884 0.47039 0.4241 0.506 rs7957932 Imputed G DOM 439 0.6888 0.212 0.4546 1.044 −1.758 0.07871 0.3884 0.47039 0.4241 0.506 rs7984504 Imputed C GEN 443 0.4224 0.8096 0.3222 0.31603 0.3063 0.3234 rs7999518 Imputed A REC 423 0.4462 0.248 0.2745 0.7255 −3.254 0.001137 0.6979 0.49882 0.4385 0.543 rs8026245 Imputed G GEN 442 2.296 0.3173 1 0.23416 0.2539 0.2191 rs8026245 Imputed G REC 442 1.888 0.4309 0.8114 4.394 1.475 0.1402 1 0.23416 0.2539 0.2191 rs8060725 Genotyped A ADD 443 0.6772 0.162 0.493 0.9303 −2.406 0.01613 0.8062 0.26298 0.2225 0.2937 rs8103016 Genotyped A ADD 443 1.223 0.1622 0.8901 1.681 1.242 0.2142 0.4981 0.22573 0.2461 0.2103 rs8103016 Genotyped A DOM 443 1.343 0.1996 0.9084 1.987 1.479 0.1391 0.4981 0.22573 0.2461 0.2103 rs8104182 Imputed G ADD 440 1.298 0.1657 0.9382 1.796 1.575 0.1152 0.8882 0.21591 0.2407 0.1972 rs8104182 Imputed G DOM 440 1.4 0.1997 0.9468 2.071 1.686 0.09175 0.8882 0.21591 0.2407 0.1972 rs8129461 Imputed G ADD 441 0.3726 0.3715 0.1799 0.7717 −2.657 0.007877 0.2921 0.04989 0.0262 0.068 rs8129461 Imputed G DOM 441 0.3187 0.3953 0.1469 0.6915 −2.893 0.003814 0.2921 0.04989 0.0262 0.068 rs8130021 Imputed G ADD 442 0.4152 0.3729 0.1999 0.8624 −2.357 0.01842 0.2362 0.04638 0.0262 0.0618 rs8130021 Imputed G DOM 442 0.3565 0.3985 0.1632 0.7784 −2.589 0.009634 0.2362 0.04638 0.0262 0.0618 rs879961 Imputed T ADD 440 1.178 0.1585 0.8634 1.607 1.033 0.3014 0.1949 0.28182 0.2974 0.27 rs879961 Imputed T DOM 440 1.245 0.1948 0.8502 1.825 1.127 0.2598 0.1949 0.28182 0.2974 0.27 rs906353 Imputed A DOM 434 1.22 0.1967 0.8295 1.794 1.01 0.3127 0.651 0.3053 0.3172 0.2964 rs915491 Imputed C DOM 441 1.329 0.1967 0.9042 1.955 1.448 0.1476 0.1184 0.30839 0.3474 0.2789 rs915493 Imputed T DOM 441 1.329 0.1967 0.9042 1.955 1.448 0.1476 0.1184 0.30839 0.3474 0.2789 rs915494 Imputed A ADD 422 1.399 0.1473 1.048 1.868 2.281 0.02256 0.1185 0.32227 0.3683 0.286 rs915494 Imputed A DOM 422 1.486 0.1999 1.004 2.199 1.982 0.0475 0.1185 0.32227 0.3683 0.286 rs917295 Imputed G DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs9284851 Imputed A GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs9293464 Imputed T REC 435 1.207 0.2381 0.7571 1.925 0.791 0.429 0.9232 0.45862 0.4545 0.4617 rs9295154 Genotyped G DOM 443 1.463 0.2215 0.9479 2.259 1.719 0.08569 0.2326 0.13995 0.1545 0.129 rs9310221 Imputed A DOM 393 0.8966 0.2237 0.5784 1.39 −0.4881 0.6255 0.1503 0.42875 0.426 0.4308 rs9310699 Genotyped T GEN 443 0.308 0.8573 0.5114 0.31828 0.322 0.3155 rs9310700 Imputed C ADD 443 1.048 0.1481 0.7837 1.401 0.3148 0.7529 0.7429 0.31941 0.3246 0.3155 rs9310700 Imputed C GEN 443 0.8065 0.6682 0.7429 0.31941 0.3246 0.3155 rs9310701 Imputed G GEN 443 1.33 0.5142 0.9151 0.33409 0.3429 0.3274 rs9310704 Imputed G GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs9319185 Imputed C GEN 441 0.9349 0.6266 0.4378 0.31293 0.2989 0.3234 rs9319186 Imputed T GEN 443 0.4224 0.8096 0.3222 0.31603 0.3063 0.3234 rs9327555 Imputed T DOM 443 0.5934 0.2016 0.3997 0.881 −2.589 0.009637 0.1134 0.34312 0.3115 0.3671 rs9403367 Imputed C DOM 443 1.038 0.1992 0.7027 1.534 0.1891 0.85 0.3391 0.2246 0.2225 0.2262 rs9419608 Imputed G REC 430 0.5885 0.2576 0.3552 0.9749 −2.059 0.03953 0.3324 0.45814 0.4098 0.4939 rs9426437 Imputed T DOM 424 1.067 0.2164 0.6984 1.631 0.3009 0.7635 0.3217 0.43042 0.4355 0.4265 rs9454967 Imputed G DOM 441 0.9744 0.2621 0.583 1.629 −0.09893 0.9212 0.07328 0.0907 0.0895 0.0916 rs9635511 Imputed T DOM 436 0.8692 0.2057 0.5809 1.301 −0.6814 0.4956 0.7678 0.41399 0.3915 0.4312 rs966583 Imputed A ADD 439 0.7596 0.1431 0.5738 1.005 −1.922 0.05464 1 0.40091 0.3658 0.4277 rs966583 Imputed A DOM 439 0.6781 0.203 0.4555 1.01 −1.913 0.0557 1 0.40091 0.3658 0.4277 rs980263 Imputed T GEN 443 1.33 0.5142 0.9151 0.33409 0.3429 0.3274 rs980264 Imputed T GEN 443 1.33 0.5142 0.9151 0.33409 0.3429 0.3274 rs9812206 Imputed G ADD 442 1.042 0.2668 0.6177 1.758 0.1545 0.8772 0.09556 0.07692 0.0785 0.0757 rs9812206 Imputed G DOM 442 1.042 0.2668 0.6177 1.758 0.1545 0.8772 0.09556 0.07692 0.0785 0.0757 rs9813552 Imputed G ADD 442 1.042 0.2623 0.6235 1.743 0.1586 0.874 0.4984 0.07692 0.0785 0.0757 rs9813552 Imputed G DOM 442 1.077 0.2681 0.6368 1.821 0.2766 0.7821 0.4984 0.07692 0.0785 0.0757 rs9815037 Imputed T ADD 443 1.048 0.2622 0.6267 1.752 0.1778 0.8589 0.4982 0.07675 0.0785 0.0754 rs9815037 Imputed T DOM 443 1.083 0.2681 0.6401 1.831 0.2958 0.7674 0.4982 0.07675 0.0785 0.0754 rs9819583 Imputed T GEN 443 0.308 0.8573 0.5114 0.31828 0.322 0.3155 rs9825349 Imputed A ADD 443 1.048 0.2622 0.6267 1.752 0.1778 0.8589 0.4982 0.07675 0.0785 0.0754 rs9825349 Imputed A DOM 443 1.083 0.2681 0.6401 1.831 0.2958 0.7674 0.4982 0.07675 0.0785 0.0754 rs9833118 Imputed G ADD 443 1.048 0.1481 0.7837 1.401 0.3148 0.7529 0.7429 0.31941 0.3246 0.3155 rs9833118 Imputed G GEN 443 0.8065 0.6682 0.7429 0.31941 0.3246 0.3155 rs9834217 Imputed T ADD 443 1.017 0.2611 0.6096 1.696 0.06425 0.9488 0.5011 0.07788 0.0785 0.0774 rs9834217 Imputed T DOM 443 1.049 0.2668 0.6218 1.77 0.179 0.858 0.5011 0.07788 0.0785 0.0774 rs9838563 Imputed C GEN 437 1.084 0.5817 1 0.33066 0.3413 0.3226 rs9840460 Imputed T ADD 443 1.017 0.2611 0.6096 1.696 0.06425 0.9488 0.5011 0.07788 0.0785 0.0774 rs9840460 Imputed T DOM 443 1.049 0.2668 0.6218 1.77 0.179 0.858 0.5011 0.07788 0.0785 0.0774 rs9840756 Imputed A ADD 437 0.9995 0.2614 0.5988 1.668 −0.00192 0.9985 0.5026 0.07895 0.0789 0.0789 rs9840756 Imputed A DOM 437 1.031 0.2671 0.6105 1.74 0.1127 0.9103 0.5026 0.07895 0.0789 0.0789 rs9847999 Imputed C GEN 436 1.977 0.3722 1 0.34633 0.3537 0.3407 rs9864769 Imputed C GEN 443 1.33 0.5142 0.9151 0.33409 0.3429 0.3274 rs9866421 Genotyped C REC 443 0.5895 0.2541 0.3583 0.9701 −2.08 0.03756 0.2848 0.42551 0.3979 0.4464 rs987296 Imputed T GEN 441 0.3297 0.848 0.5103 0.31859 0.322 0.316 rs9881685 Imputed A ADD 440 1.041 0.2668 0.6172 1.756 0.151 0.88 0.09541 0.07727 0.0789 0.076 rs9881685 Imputed A DOM 440 1.041 0.2668 0.6172 1.756 0.151 0.88 0.09541 0.07727 0.0789 0.076 rs992695 Imputed C ADD 442 1.16 0.158 0.8507 1.581 0.9366 0.3489 0.1596 0.28281 0.2974 0.2718 rs992695 Imputed C DOM 442 1.216 0.194 0.8313 1.778 1.008 0.3136 0.1596 0.28281 0.2974 0.2718 rs9936999 Imputed G DOM 266 0.7758 0.254 0.4716 1.276 −0.9992 0.3177 0.2862 0.35714 0.3571 0.3571 ALLELE PRAVA_(—) PRAVA_(—) PRAVA_A2_(—) SNP rs # SOURCE (A1) MODEL NMISS ATORVA_A1_HZ_COUNT ATORVA_HET_COUNT ATORVA_A2_HZ_COUNT A1_HZ_COUNT HET_COUNT HZ_COUNT rs77638540 Genotyped T DOM 443 1 10 180 1 33 218 rs72746987 Genotyped A DOM 443 0 16 175 0 21 231 rs10021016 Genotyped G GEN 443 20 74 97 12 95 145 rs10021016 Genotyped G REC 443 20 74 97 12 95 145 rs10051148 Imputed C DOM 443 20 67 104 23 120 109 rs10054055 Imputed T DOM 440 23 65 101 29 120 102 rs10067895 Imputed A DOM 440 27 65 98 35 118 97 rs10100725 Imputed C DOM 443 9 53 129 8 71 173 rs10128531 Imputed T ADD 415 6 50 122 3 46 188 rs10181743 Imputed G ADD 417 35 90 54 40 119 79 rs10199127 Imputed T DOM 431 17 84 86 34 97 113 rs10270624 Imputed G DOM 409 8 59 112 7 63 160 rs1030006 Imputed G REC 434 40 92 55 58 120 69 rs1031811 Imputed A REC 434 29 77 81 16 107 124 rs10430870 Genotyped G GEN 443 20 69 102 9 93 150 rs10430870 Genotyped G REC 443 20 69 102 9 93 150 rs10469597 Imputed A GEN 411 13 66 98 15 104 115 rs10469597 Imputed A REC 411 13 66 98 15 104 115 rs10478919 Imputed G DOM 443 26 66 99 34 118 100 rs10506623 Imputed C ADD 442 26 86 78 45 121 86 rs10506623 Imputed C DOM 442 26 86 78 45 121 86 rs10506626 Imputed A ADD 443 26 84 81 46 121 85 rs10506626 Imputed A DOM 443 26 84 81 46 121 85 rs10509477 Imputed T DOM 443 29 83 79 27 101 124 rs10517918 Imputed G REC 433 32 98 58 43 122 80 rs10517924 Imputed A REC 442 42 94 55 52 126 73 rs10519362 Imputed G DOM 434 6 58 122 6 54 188 rs10520072 Imputed T DOM 443 27 65 99 33 119 100 rs10737390 Imputed T DOM 418 30 90 59 35 122 82 rs10742851 Imputed T REC 443 18 80 93 16 109 127 rs10743685 Imputed G GEN 435 34 95 59 33 131 83 rs10743685 Imputed G REC 435 34 95 59 33 131 83 rs10749293 Imputed G DOM 441 26 84 80 26 96 129 rs10749294 Imputed A DOM 443 23 78 90 19 95 138 rs10753760 Imputed T ADD 423 36 80 69 50 102 86 rs10753760 Imputed T GEN 423 36 80 69 50 102 86 rs10772362 Imputed T ADD 443 7 65 119 12 93 147 rs10784891 Imputed C ADD 422 30 89 65 58 111 69 rs10784891 Imputed C DOM 422 30 89 65 58 111 69 rs10784891 Imputed C GEN 422 30 89 65 58 111 69 rs10787923 Imputed G DOM 439 26 83 79 26 96 129 rs10787924 Imputed T DOM 443 23 78 90 19 95 138 rs10787949 Imputed A DOM 442 29 84 78 29 100 122 rs10787951 Imputed G DOM 441 29 83 78 29 100 122 rs10787983 Imputed C DOM 441 29 83 79 27 100 123 rs10794733 Imputed C ADD 439 13 73 104 32 110 107 rs10818280 Imputed C DOM 432 10 71 106 21 114 110 rs10860586 Imputed A ADD 431 44 93 48 67 121 58 rs10860586 Imputed A GEN 431 44 93 48 67 121 58 rs10870473 Imputed A ADD 177 4 35 28 12 39 59 rs10870473 Imputed A DOM 177 4 35 28 12 39 59 rs10879240 Imputed C ADD 428 30 92 66 60 111 69 rs10879240 Imputed C GEN 428 30 92 66 60 111 69 rs10879242 Imputed A ADD 421 26 86 73 45 116 75 rs10879242 Imputed A DOM 421 26 86 73 45 116 75 rs10879245 Imputed G ADD 421 26 86 73 45 116 75 rs10879245 Imputed G DOM 421 26 86 73 45 116 75 rs10879249 Imputed T ADD 440 26 87 77 45 121 84 rs10879249 Imputed T DOM 440 26 87 77 45 121 84 rs10886429 Imputed A DOM 441 29 82 80 27 101 122 rs10886449 Imputed G DOM 440 28 76 86 21 97 132 rs10886451 Imputed G DOM 440 28 76 86 21 97 132 rs10886452 Imputed A DOM 440 30 82 78 26 101 123 rs10886456 Imputed G DOM 440 28 76 86 21 97 132 rs10886463 Imputed C DOM 442 30 83 78 29 100 122 rs10886465 Imputed A DOM 441 30 83 78 28 100 122 rs10886526 Imputed C DOM 439 28 83 78 26 101 123 rs10922903 Imputed C REC 440 34 99 56 46 120 85 rs10941126 Imputed G ADD 443 3 22 166 7 23 222 rs10941126 Imputed G DOM 443 3 22 166 7 23 222 rs10947980 Imputed G ADD 439 10 80 100 17 97 135 rs11059376 Imputed T ADD 401 3 53 118 8 57 162 rs11072995 Imputed T GEN 439 13 59 118 8 74 167 rs11072995 Imputed T REC 439 13 59 118 8 74 167 rs11081202 Genotyped G GEN 443 22 66 103 10 97 145 rs11081202 Genotyped G REC 443 22 66 103 10 97 145 rs110965 Imputed C GEN 420 34 77 71 17 112 109 rs11124962 Imputed A DOM 437 11 78 101 21 81 145 rs1116596 Imputed T DOM 443 26 66 99 34 118 100 rs11178531 Imputed A ADD 439 34 92 64 67 117 65 rs11178531 Imputed A DOM 439 34 92 64 67 117 65 rs11178583 Imputed A ADD 443 26 87 78 45 121 86 rs11178583 Imputed A DOM 443 26 87 78 45 121 86 rs11178589 Imputed T ADD 437 26 87 77 45 120 82 rs11178589 Imputed T DOM 437 26 87 77 45 120 82 rs11178594 Imputed C ADD 441 26 88 76 45 125 81 rs11178594 Imputed C DOM 441 26 88 76 45 125 81 rs11178602 Imputed T ADD 439 26 87 76 45 124 81 rs11178602 Imputed T DOM 439 26 87 76 45 124 81 rs11178648 Imputed T ADD 440 26 83 80 46 120 85 rs11178648 Imputed T DOM 440 26 83 80 46 120 85 rs11198877 Imputed T DOM 441 30 82 78 26 102 123 rs11198942 Imputed T DOM 443 29 83 79 27 101 124 rs11221075 Imputed A ADD 417 0 27 152 5 58 175 rs11242020 Imputed T DOM 443 26 66 99 34 118 100 rs11242021 Imputed T DOM 443 27 65 99 33 119 100 rs11242022 Imputed T DOM 443 27 65 99 33 119 100 rs11242023 Imputed T DOM 443 27 65 99 33 119 100 rs1149349 Imputed T DOM 434 1 55 133 11 54 180 rs1149350 Imputed A ADD 443 6 60 125 24 70 158 rs1149350 Imputed A DOM 443 6 60 125 24 70 158 rs11576627 Imputed T ADD 441 7 43 140 6 40 205 rs11576627 Imputed T DOM 441 7 43 140 6 40 205 rs11630050 Imputed G GEN 442 14 69 108 10 90 151 rs11630050 Imputed G REC 442 14 69 108 10 90 151 rs11633024 Imputed C GEN 442 14 69 108 10 90 151 rs11633024 Imputed C REC 442 14 69 108 10 90 151 rs11636298 Imputed G GEN 443 13 64 114 9 81 162 rs11636298 Imputed G REC 443 13 64 114 9 81 162 rs11637363 Imputed C GEN 420 14 65 105 10 84 142 rs11637363 Imputed C REC 420 14 65 105 10 84 142 rs11637813 Imputed A GEN 442 14 69 108 10 90 151 rs11637813 Imputed A REC 442 14 69 108 10 90 151 rs11638043 Imputed C GEN 420 14 65 105 10 84 142 rs11638043 Imputed C REC 420 14 65 105 10 84 142 rs11638115 Imputed A GEN 439 13 59 118 8 74 167 rs11638115 Imputed A REC 439 13 59 118 8 74 167 rs11638444 Imputed C GEN 442 13 64 113 10 81 161 rs11682946 Imputed A ADD 86 0 12 28 0 5 41 rs11682946 Imputed A DOM 86 0 12 28 0 5 41 rs11717157 Imputed T ADD 442 19 86 86 28 102 121 rs11717157 Imputed T GEN 442 19 86 86 28 102 121 rs11724055 Imputed A DOM 443 6 37 148 7 81 164 rs11743355 Imputed C ADD 443 3 22 166 7 23 222 rs11743355 Imputed C DOM 443 3 22 166 7 23 222 rs11746806 Imputed T ADD 443 3 22 166 7 23 222 rs11746806 Imputed T DOM 443 3 22 166 7 23 222 rs11746959 Imputed T ADD 443 3 22 166 7 23 222 rs11746959 Imputed T DOM 443 3 22 166 7 23 222 rs11749272 Imputed T DOM 443 26 66 99 34 118 100 rs11839636 Imputed C GEN 441 17 79 93 30 103 119 rs11839785 Imputed C GEN 441 17 79 93 30 103 119 rs11853619 Imputed C GEN 440 13 63 114 9 80 161 rs11853619 Imputed C REC 440 13 63 114 9 80 161 rs11856780 Imputed A GEN 440 13 63 114 9 80 161 rs11856780 Imputed A REC 440 13 63 114 9 80 161 rs11901899 Imputed A DOM 426 14 85 85 14 94 134 rs11903290 Imputed C REC 434 29 77 81 16 107 124 rs11909480 Imputed G ADD 439 1 8 181 1 29 219 rs11909480 Imputed G DOM 439 1 8 181 1 29 219 rs11910289 Imputed T ADD 440 4 34 153 2 28 219 rs11910289 Imputed T DOM 440 4 34 153 2 28 219 rs11920375 Genotyped C GEN 443 19 90 82 30 103 119 rs11926319 Imputed G DOM 443 0 29 162 1 37 214 rs11933744 Imputed T REC 440 18 70 101 27 108 116 rs11934919 Imputed C REC 441 17 71 101 26 109 117 rs11934957 Imputed C REC 441 17 71 101 26 109 117 rs11959206 Imputed A REC 434 43 84 60 49 130 68 rs12038613 Imputed C REC 404 33 90 51 47 111 72 rs12151417 Imputed T DOM 442 9 75 107 12 73 166 rs12153185 Imputed T DOM 441 27 65 98 36 118 97 rs12182651 Imputed T DOM 441 3 28 159 4 38 209 rs12235345 Imputed C DOM 443 2 23 166 0 20 232 rs12324786 Imputed T GEN 439 13 59 118 8 74 167 rs12324786 Imputed T REC 439 13 59 118 8 74 167 rs12336958 Imputed G DOM 407 23 80 71 38 111 84 rs12407412 Imputed C ADD 441 7 43 140 6 40 205 rs12407412 Imputed C DOM 441 7 43 140 6 40 205 rs12418971 Imputed C GEN 436 20 69 100 9 89 149 rs12418971 Imputed C REC 436 20 69 100 9 89 149 rs1241967 Imputed T REC 443 18 95 78 34 113 105 rs12420184 Imputed G DOM 438 4 56 129 5 57 187 rs12433968 Imputed T DOM 419 14 89 80 18 112 106 rs12445477 Imputed A DOM 427 3 23 158 2 43 198 rs12447191 Genotyped T ADD 443 5 43 143 5 77 170 rs12447191 Genotyped T DOM 443 5 43 143 5 77 170 rs12465349 Imputed A REC 434 69 78 40 61 140 46 rs1247340 Imputed C ADD 441 4 60 126 22 69 160 rs1247340 Imputed C DOM 441 4 60 126 22 69 160 rs1247341 Imputed C ADD 441 4 61 126 21 69 160 rs1247341 Imputed C DOM 441 4 61 126 21 69 160 rs1247343 Imputed C DOM 441 1 55 134 17 54 180 rs12509758 Imputed C DOM 436 7 68 112 17 65 167 rs12515472 Imputed A DOM 443 6 62 123 5 52 195 rs12548906 Imputed G ADD 415 10 67 100 6 64 168 rs12596240 Imputed G DOM 443 26 99 66 51 119 82 rs12618781 Imputed A DOM 440 40 98 51 56 124 71 rs12678600 Imputed A DOM 439 18 77 94 26 113 111 rs12692229 Imputed T ADD 443 31 94 66 19 117 116 rs12713324 Imputed T DOM 443 9 75 107 12 74 166 rs12719415 Imputed T DOM 443 27 65 99 33 119 100 rs12820589 Imputed G ADD 418 5 59 120 11 75 148 rs12820589 Imputed G DOM 418 5 59 120 11 75 148 rs12831292 Imputed G ADD 436 26 86 74 45 124 81 rs12831292 Imputed G DOM 436 26 86 74 45 124 81 rs13012636 Imputed G REC 433 29 77 80 16 107 124 rs13038146 Imputed C ADD 443 34 80 77 24 109 119 rs13038146 Imputed C GEN 443 34 80 77 24 109 119 rs13038146 Imputed C REC 443 34 80 77 24 109 119 rs13089860 Imputed A DOM 364 39 63 61 50 97 54 rs13102419 Imputed T REC 439 42 94 54 51 125 73 rs13194907 Imputed A ADD 443 1 27 163 3 30 219 rs13194907 Imputed A DOM 443 1 27 163 3 30 219 rs13195745 Imputed A ADD 443 1 27 163 3 30 219 rs13195745 Imputed A DOM 443 1 27 163 3 30 219 rs13265054 Imputed T DOM 434 17 76 94 25 114 108 rs13273002 Imputed A GEN 443 6 59 126 9 80 163 rs13282131 Imputed C ADD 440 47 85 58 39 129 82 rs13282131 Imputed C GEN 440 47 85 58 39 129 82 rs13282131 Imputed C REC 440 47 85 58 39 129 82 rs1330052 Imputed G GEN 443 19 89 83 35 112 105 rs1335721 Imputed A REC 406 33 91 51 47 111 73 rs1336382 Imputed T DOM 443 29 83 79 27 101 124 rs1336383 Imputed T DOM 443 29 83 79 27 101 124 rs1336407 Imputed T DOM 442 29 83 79 27 101 123 rs1336409 Imputed T DOM 442 29 83 79 27 101 123 rs1336596 Imputed A DOM 440 28 87 75 28 126 96 rs13387284 Imputed A DOM 408 31 93 50 43 120 71 rs13401462 Imputed C DOM 417 50 80 48 58 123 58 rs13409045 Imputed T ADD 442 36 96 59 55 110 86 rs1349284 Imputed C GEN 443 20 83 88 28 103 121 rs1355715 Imputed T ADD 442 0 18 173 1 31 219 rs1357696 Imputed A GEN 434 19 93 75 31 105 111 rs1357698 Imputed A GEN 436 20 93 75 32 105 111 rs1357699 Imputed T GEN 436 20 93 75 32 105 111 rs1363273 Imputed C REC 421 43 90 50 58 122 58 rs1373601 Imputed A DOM 404 26 80 64 27 120 87 rs1375829 Imputed C GEN 443 20 83 88 28 103 121 rs1395748 Imputed G DOM 441 17 89 85 23 104 123 rs1414865 Imputed T DOM 442 29 84 78 29 100 122 rs1414873 Imputed A DOM 442 29 83 79 27 101 123 rs1414876 Imputed C DOM 442 29 83 79 27 101 123 rs1424643 Imputed G ADD 430 11 74 99 13 69 164 rs1424643 Imputed G DOM 430 11 74 99 13 69 164 rs1424648 Imputed T DOM 438 11 74 105 12 71 165 rs1429321 Imputed A DOM 432 10 72 105 12 71 162 rs1429326 Imputed T ADD 433 9 70 109 10 67 168 rs1429326 Imputed T DOM 433 9 70 109 10 67 168 rs1444741 Imputed A DOM 407 24 79 68 22 119 95 rs1449916 Imputed C DOM 270 33 53 32 44 75 33 rs1459523 Imputed A ADD 442 19 86 86 28 102 121 rs1459523 Imputed A GEN 442 19 86 86 28 102 121 rs1466352 Imputed T GEN 443 20 91 80 30 105 117 rs1466353 Imputed G GEN 443 20 91 80 30 105 117 rs1476714 Imputed A DOM 439 27 65 98 33 118 98 rs1486723 Imputed C REC 434 17 90 78 37 122 90 rs1495375 Imputed A ADD 421 26 86 73 45 116 75 rs1495375 Imputed A DOM 421 26 86 73 45 116 75 rs1495381 Imputed T GEN 442 35 95 60 25 126 101 rs1495381 Imputed T REC 442 35 95 60 25 126 101 rs1498061 Imputed C ADD 200 1 22 60 8 36 73 rs1498992 Imputed G DOM 428 22 75 87 34 113 97 rs1499001 Imputed T DOM 437 16 66 105 24 102 124 rs1512988 Imputed A ADD 442 26 86 78 45 121 86 rs1512988 Imputed A DOM 442 26 86 78 45 121 86 rs1512989 Imputed T ADD 442 26 86 78 45 121 86 rs1512989 Imputed T DOM 442 26 86 78 45 121 86 rs1512991 Imputed T ADD 425 30 89 64 63 113 66 rs1512991 Imputed T DOM 425 30 89 64 63 113 66 rs1512991 Imputed T GEN 425 30 89 64 63 113 66 rs1524303 Imputed T GEN 436 19 86 83 28 101 119 rs1524306 Imputed C ADD 441 19 86 86 28 102 120 rs1524306 Imputed C GEN 441 19 86 86 28 102 120 rs1524310 Imputed G ADD 438 19 85 86 27 101 120 rs1524310 Imputed G GEN 438 19 85 86 27 101 120 rs1524321 Imputed C GEN 441 20 91 80 28 105 117 rs1527059 Imputed A DOM 441 1 24 165 0 62 189 rs152707 Imputed A ADD 443 34 94 63 43 119 90 rs152707 Imputed A GEN 443 34 94 63 43 119 90 rs152712 Genotyped C ADD 443 34 94 63 43 119 90 rs152712 Genotyped C GEN 443 34 94 63 43 119 90 rs1533994 Imputed T GEN 443 20 91 80 30 105 117 rs1535866 Imputed G DOM 440 7 72 111 14 71 165 rs1563773 Imputed T GEN 439 20 90 79 30 105 115 rs1563774 Imputed T GEN 439 20 90 79 30 105 115 rs1567740 Imputed T ADD 439 26 87 77 45 121 83 rs1567740 Imputed T DOM 439 26 87 77 45 121 83 rs1572573 Imputed A DOM 396 2 61 110 3 78 142 rs1577497 Imputed C REC 408 33 91 52 47 112 73 rs1581514 Imputed T ADD 429 19 86 80 28 101 115 rs1581514 Imputed T GEN 429 19 86 80 28 101 115 rs1582321 Imputed T DOM 443 26 99 66 51 119 82 rs1582322 Imputed A DOM 438 26 98 66 49 119 80 rs1582323 Imputed A DOM 437 26 98 66 48 119 80 rs1592485 Imputed C DOM 443 32 95 64 58 116 78 rs1600954 Imputed T ADD 423 47 92 46 52 114 72 rs1600954 Imputed T GEN 423 47 92 46 52 114 72 rs16938626 Imputed G DOM 435 15 63 109 19 100 129 rs16964300 Imputed G ADD 439 6 43 140 5 80 165 rs16964300 Imputed G DOM 439 6 43 140 5 80 165 rs16986282 Imputed G DOM 442 1 8 182 1 29 221 rs17007620 Imputed G ADD 408 7 66 104 13 75 143 rs17007620 Imputed G DOM 408 7 66 104 13 75 143 rs17014326 Imputed G DOM 441 16 88 87 24 101 125 rs17047957 Imputed C DOM 439 7 64 118 7 56 187 rs1705261 Imputed A REC 442 37 93 60 28 125 99 rs17073341 Imputed A ADD 441 1 17 172 1 10 240 rs17073341 Imputed A DOM 441 1 17 172 1 10 240 rs17138702 Imputed G ADD 443 9 45 137 6 62 184 rs17189710 Imputed T ADD 430 33 77 75 23 108 114 rs17189710 Imputed T GEN 430 33 77 75 23 108 114 rs17189710 Imputed T REC 430 33 77 75 23 108 114 rs17310176 Imputed T ADD 443 4 43 144 9 79 164 rs17310176 Imputed T DOM 443 4 43 144 9 79 164 rs17358860 Imputed A DOM 416 9 38 134 9 83 143 rs17370541 Imputed T GEN 397 24 85 64 28 113 83 rs17370541 Imputed T REC 397 24 85 64 28 113 83 rs17526574 Imputed G GEN 443 19 79 93 30 103 119 rs17530747 Imputed T DOM 374 14 82 64 18 106 90 rs17649114 Imputed C DOM 440 12 63 114 10 59 182 rs17766172 Imputed A REC 428 17 84 81 38 102 106 rs1818885 Imputed G GEN 443 19 86 86 28 103 121 rs1832222 Imputed G DOM 443 29 83 79 27 102 123 rs1861327 Imputed G DOM 433 26 98 64 51 116 78 rs1868581 Imputed G ADD 436 19 83 86 28 101 119 rs1868581 Imputed G GEN 436 19 83 86 28 101 119 rs1874313 Imputed A ADD 443 26 87 78 45 121 86 rs1874313 Imputed A DOM 443 26 87 78 45 121 86 rs1876409 Imputed C DOM 443 17 89 85 25 104 123 rs1913201 Imputed G ADD 432 30 90 65 63 116 68 rs1913201 Imputed G DOM 432 30 90 65 63 116 68 rs1913201 Imputed G GEN 432 30 90 65 63 116 68 rs1916922 Imputed T GEN 435 19 83 86 27 101 119 rs1936871 Genotyped G DOM 443 40 86 65 49 129 74 rs1961157 Imputed T REC 442 41 96 54 48 131 72 rs1987179 Imputed T ADD 417 6 37 139 7 81 147 rs1987179 Imputed T DOM 417 6 37 139 7 81 147 rs1990023 Imputed T DOM 443 26 66 99 34 118 100 rs1995025 Imputed C DOM 433 4 61 121 2 57 188 rs2016194 Imputed G DOM 443 27 65 99 33 119 100 rs2023651 Imputed T ADD 429 13 62 109 14 72 159 rs2024902 Imputed A ADD 442 1 27 163 3 30 218 rs2024902 Imputed A DOM 442 1 27 163 3 30 218 rs2025107 Imputed A DOM 442 3 28 159 4 38 210 rs2025108 Imputed T DOM 442 3 28 159 4 38 210 rs2031987 Imputed T GEN 443 19 79 93 30 103 119 rs2052428 Imputed C DOM 427 46 79 60 58 122 62 rs2053230 Imputed C ADD 391 0 61 109 2 86 133 rs2062448 Imputed T DOM 442 0 28 162 0 40 212 rs2063420 Imputed C REC 442 32 101 57 47 128 77 rs2063591 Imputed C ADD 441 36 92 63 69 117 64 rs2063591 Imputed C DOM 441 36 92 63 69 117 64 rs208026 Genotyped A DOM 443 8 81 102 11 79 162 rs208029 Imputed T DOM 422 7 75 101 10 60 169 rs208757 Imputed G DOM 435 8 73 108 10 60 176 rs2095586 Imputed A DOM 442 28 84 79 25 103 123 rs2095606 Imputed A DOM 436 27 90 70 28 132 89 rs2102374 Imputed A ADD 437 13 87 90 16 104 127 rs2102374 Imputed A DOM 437 13 87 90 16 104 127 rs2108426 Imputed C DOM 443 27 65 99 33 119 100 rs2110664 Imputed A DOM 399 14 77 81 16 83 128 rs2132242 Imputed A ADD 440 26 88 76 45 125 80 rs2132242 Imputed A DOM 440 26 88 76 45 125 80 rs2158958 Imputed A DOM 443 27 65 99 33 119 100 rs2158961 Imputed G DOM 443 20 67 104 23 120 109 rs2163046 Imputed A DOM 436 9 75 105 12 72 163 rs2180286 Imputed G DOM 443 49 82 60 69 130 53 rs2180684 Imputed A DOM 433 3 49 134 5 37 205 rs2188079 Imputed C ADD 443 39 92 60 43 133 76 rs2188079 Imputed C GEN 443 39 92 60 43 133 76 rs2190598 Imputed T DOM 443 27 65 99 33 119 100 rs2190600 Imputed A DOM 440 27 65 98 35 118 97 rs2224184 Genotyped T DOM 443 49 82 60 68 131 53 rs2247066 Imputed A DOM 441 17 89 85 23 104 123 rs2248236 Imputed C ADD 443 9 47 135 9 100 143 rs2248236 Imputed C DOM 443 9 47 135 9 100 143 rs2265733 Imputed C ADD 437 13 87 90 16 104 127 rs2265733 Imputed C DOM 437 13 87 90 16 104 127 rs2270584 Imputed A ADD 441 26 83 81 46 120 85 rs2270584 Imputed A DOM 441 26 83 81 46 120 85 rs2270586 Imputed A ADD 442 26 84 81 46 120 85 rs2270586 Imputed A DOM 442 26 84 81 46 120 85 rs229775 Imputed A REC 443 18 95 78 34 113 105 rs229815 Imputed T REC 432 20 103 64 39 109 97 rs229829 Imputed C REC 413 19 97 59 41 103 94 rs229831 Imputed A REC 441 17 96 77 34 113 104 rs2317057 Imputed T ADD 368 4 47 112 11 81 113 rs2322100 Genotyped T REC 443 20 71 100 11 95 146 rs2322101 Imputed A REC 440 20 71 98 11 95 145 rs2327929 Imputed G REC 441 42 87 62 43 121 86 rs2332844 Imputed A ADD 282 89 28 3 110 49 3 rs2332844 Imputed A REC 282 89 28 3 110 49 3 rs2349170 Imputed G DOM 443 18 68 105 14 78 160 rs2356722 Imputed G DOM 443 16 88 87 23 101 128 rs2364956 Imputed T ADD 415 5 51 122 10 50 177 rs2373793 Imputed G ADD 435 6 54 130 3 52 190 rs2373793 Imputed G DOM 435 6 54 130 3 52 190 rs238252 Imputed G ADD 434 3 48 137 4 54 188 rs238252 Imputed G DOM 434 3 48 137 4 54 188 rs2383903 Imputed G DOM 443 15 64 112 19 102 131 rs2387945 Imputed G DOM 436 4 62 122 2 57 189 rs2389863 Imputed A DOM 432 9 46 131 9 96 141 rs2389866 Imputed C DOM 443 9 47 135 9 100 143 rs2389869 Imputed C DOM 443 9 47 135 9 100 143 rs2389870 Genotyped C DOM 443 6 38 147 7 84 161 rs2418494 Imputed G ADD 423 40 98 43 79 122 41 rs2418494 Imputed G GEN 423 40 98 43 79 122 41 rs2418541 Imputed A DOM 443 26 66 99 34 118 100 rs2418542 Imputed A DOM 443 26 66 99 34 118 100 rs2423556 Imputed C DOM 433 49 77 56 69 130 52 rs2437688 Imputed C ADD 443 3 46 142 0 38 214 rs2456809 Imputed G DOM 438 17 87 84 25 104 121 rs2456811 Imputed T ADD 436 13 87 89 16 104 127 rs2456811 Imputed T DOM 436 13 87 89 16 104 127 rs2476976 Imputed C DOM 442 27 85 79 26 100 125 rs2484911 Imputed A DOM 443 26 78 87 22 96 134 rs2488557 Imputed C DOM 431 0 45 141 5 57 183 rs250162 Imputed C ADD 429 5 62 119 11 103 129 rs250162 Imputed C DOM 429 5 62 119 11 103 129 rs2560708 Imputed T ADD 436 5 48 137 10 75 161 rs2617841 Imputed G DOM 412 14 56 106 14 97 125 rs2622499 Imputed G DOM 443 9 47 135 9 100 143 rs264129 Imputed T DOM 443 20 67 104 23 120 109 rs2642936 Imputed T ADD 428 6 58 119 6 83 156 rs2660633 Imputed A DOM 443 17 89 85 25 104 123 rs2660634 Imputed C DOM 443 17 89 85 25 104 123 rs2660648 Imputed A ADD 437 13 87 90 16 104 127 rs2660648 Imputed A DOM 437 13 87 90 16 104 127 rs2681505 Imputed T ADD 443 7 66 118 12 93 147 rs277411 Imputed G DOM 442 0 17 173 0 22 230 rs2832634 Imputed G ADD 442 4 34 153 2 29 220 rs2832637 Imputed T ADD 442 4 34 153 2 29 220 rs2843167 Imputed A DOM 442 16 84 91 23 103 125 rs2876227 Imputed C ADD 442 33 82 76 23 111 117 rs2876227 Imputed C GEN 442 33 82 76 23 111 117 rs2882097 Imputed A DOM 443 29 83 79 27 101 124 rs2909862 Imputed G DOM 416 29 92 59 31 126 79 rs3001945 Imputed T DOM 435 4 61 122 2 57 189 rs3011020 Imputed C DOM 436 4 62 122 2 57 189 rs36071725 Genotyped C ADD 443 16 88 87 26 110 116 rs36071725 Genotyped C GEN 443 16 88 87 26 110 116 rs373983 Imputed G DOM 414 31 104 48 38 98 95 rs3743794 Imputed G DOM 434 26 97 65 47 120 79 rs3756154 Imputed C ADD 416 6 38 138 7 83 144 rs3756154 Imputed C DOM 416 6 38 138 7 83 144 rs3775850 Imputed A DOM 443 6 37 148 7 81 164 rs3775851 Imputed C DOM 443 6 37 148 7 81 164 rs3793044 Imputed C ADD 443 1 27 163 3 30 219 rs3793044 Imputed C DOM 443 1 27 163 3 30 219 rs3793053 Imputed C DOM 436 3 27 158 4 36 208 rs3796246 Imputed G DOM 442 0 29 162 1 38 212 rs3806003 Imputed A ADD 443 1 27 163 3 30 219 rs3806003 Imputed A DOM 443 1 27 163 3 30 219 rs3806004 Imputed T DOM 442 3 28 159 4 38 210 rs3806010 Imputed T DOM 442 3 28 159 4 38 210 rs3806014 Imputed T DOM 430 3 27 153 4 37 206 rs3806015 Imputed A DOM 426 3 27 152 4 37 203 rs3806018 Imputed A DOM 442 3 28 159 4 38 210 rs3806019 Imputed A DOM 438 3 28 158 4 38 207 rs3806024 Imputed T DOM 442 4 28 159 4 38 209 rs3915080 Imputed A GEN 436 20 93 75 32 105 111 rs3942254 Imputed T ADD 420 26 74 78 45 113 84 rs3942254 Imputed T DOM 420 26 74 78 45 113 84 rs3945085 Imputed A DOM 441 31 81 79 29 99 122 rs3976737 Imputed G ADD 377 9 41 108 4 61 154 rs399485 Imputed A DOM 437 10 91 89 15 86 146 rs4029119 Imputed G ADD 443 3 22 166 7 23 222 rs4029119 Imputed G DOM 443 3 22 166 7 23 222 rs4076201 Imputed G GEN 420 14 65 105 10 84 142 rs4076201 Imputed G REC 420 14 65 105 10 84 142 rs41395945 Imputed G ADD 441 4 34 153 2 28 220 rs41395945 Imputed G DOM 441 4 34 153 2 28 220 rs4146972 Genotyped T DOM 443 7 66 118 7 57 188 rs4238087 Imputed G DOM 402 4 26 140 4 59 169 rs4251569 Imputed T ADD 441 4 28 159 4 62 184 rs4251569 Imputed T DOM 441 4 28 159 4 62 184 rs4273613 Imputed T ADD 443 3 22 166 7 23 222 rs4273613 Imputed T DOM 443 3 22 166 7 23 222 rs4291049 Imputed T REC 432 42 84 58 50 130 68 rs4315598 Imputed T ADD 443 34 80 77 24 109 119 rs4315598 Imputed T GEN 443 34 80 77 24 109 119 rs4315598 Imputed T REC 443 34 80 77 24 109 119 rs4321395 Imputed A DOM 408 31 93 50 43 120 71 rs4321596 Genotyped T REC 443 16 66 109 10 82 160 rs4324417 Imputed T DOM 443 54 84 53 60 119 73 rs4328619 Genotyped G DOM 443 41 78 72 45 140 67 rs4338909 Imputed T ADD 440 40 84 65 52 113 86 rs4370878 Imputed G DOM 440 29 82 79 27 101 122 rs4379434 Genotyped T DOM 443 39 85 67 46 118 88 rs4416407 Imputed T DOM 437 70 79 39 81 101 67 rs4417899 Imputed C REC 437 39 79 70 67 101 81 rs4442732 Imputed A ADD 335 19 54 65 26 84 87 rs4444612 Imputed G ADD 443 34 80 77 24 109 119 rs4444612 Imputed G GEN 443 34 80 77 24 109 119 rs4444612 Imputed G REC 443 34 80 77 24 109 119 rs4450660 Imputed C DOM 438 11 78 101 21 81 146 rs4509702 Imputed C DOM 440 29 82 79 27 101 122 rs4526920 Imputed G GEN 443 19 79 93 30 103 119 rs4533145 Imputed T DOM 441 2 54 133 3 45 204 rs4557006 Imputed A DOM 401 31 93 50 43 115 69 rs4570530 Imputed C DOM 440 29 82 79 27 101 122 rs4615971 Imputed C DOM 440 28 83 79 26 101 123 rs4628119 Imputed A DOM 442 10 66 115 16 82 153 rs4664443 Imputed G ADD 442 36 96 59 55 110 86 rs4688259 Imputed T DOM 438 70 79 39 81 102 67 rs4688632 Imputed G REC 429 38 79 68 68 98 78 rs4695284 Imputed A ADD 194 0 16 60 1 16 101 rs4700302 Imputed A ADD 399 1 33 139 2 36 188 rs4702720 Imputed A ADD 359 10 48 97 12 85 107 rs4702720 Imputed A DOM 359 10 48 97 12 85 107 rs4711091 Genotyped G GEN 443 37 102 52 61 125 66 rs4714484 Imputed A ADD 439 3 49 137 5 73 172 rs4736802 Imputed G DOM 442 39 84 67 46 118 88 rs4760785 Imputed A ADD 432 30 90 65 63 116 68 rs4760785 Imputed A DOM 432 30 90 65 63 116 68 rs4760785 Imputed A GEN 432 30 90 65 63 116 68 rs4760894 Imputed T ADD 432 30 90 65 63 116 68 rs4760894 Imputed T DOM 432 30 90 65 63 116 68 rs4760894 Imputed T GEN 432 30 90 65 63 116 68 rs4760895 Imputed A ADD 432 30 90 65 63 116 68 rs4760895 Imputed A DOM 432 30 90 65 63 116 68 rs4760895 Imputed A GEN 432 30 90 65 63 116 68 rs4764738 Imputed A ADD 430 55 88 44 70 122 51 rs4764738 Imputed A GEN 430 55 88 44 70 122 51 rs4764974 Imputed T ADD 431 44 93 48 67 121 58 rs4764974 Imputed T GEN 431 44 93 48 67 121 58 rs4798366 Imputed G REC 429 25 73 89 13 110 119 rs483159 Imputed T DOM 386 4 66 94 6 55 161 rs4836502 Imputed T DOM 443 27 65 99 33 119 100 rs4836507 Imputed C DOM 442 27 66 98 35 119 97 rs4836744 Imputed A ADD 443 13 76 102 25 119 108 rs4836744 Imputed A DOM 443 13 76 102 25 119 108 rs4848944 Genotyped C REC 443 35 89 67 61 131 60 rs4851529 Imputed A DOM 442 34 79 77 49 127 76 rs4851531 Imputed T DOM 442 36 81 74 57 124 70 rs4858046 Genotyped T GEN 443 20 91 80 30 105 117 rs4878214 Imputed A ADD 261 11 40 65 22 53 70 rs4880803 Imputed A ADD 439 13 73 104 32 110 107 rs489441 Imputed G ADD 409 11 78 85 16 87 132 rs489441 Imputed G DOM 409 11 78 85 16 87 132 rs4896568 Imputed T DOM 410 10 62 104 16 78 140 rs4938851 Imputed T DOM 443 13 66 112 11 61 180 rs4964416 Imputed C DOM 443 52 80 59 61 131 60 rs5756669 Imputed C DOM 443 54 84 53 60 119 73 rs6033138 Imputed C ADD 443 34 80 77 24 109 119 rs6033138 Imputed C GEN 443 34 80 77 24 109 119 rs6033138 Imputed C REC 443 34 80 77 24 109 119 rs6040619 Imputed C ADD 439 34 81 73 24 109 118 rs6040619 Imputed C GEN 439 34 81 73 24 109 118 rs6040619 Imputed C REC 439 34 81 73 24 109 118 rs6040625 Imputed T ADD 442 34 82 75 24 109 118 rs6040625 Imputed T GEN 442 34 82 75 24 109 118 rs6040625 Imputed T REC 442 34 82 75 24 109 118 rs6040630 Imputed A ADD 441 34 80 76 24 108 119 rs6040630 Imputed A GEN 441 34 80 76 24 108 119 rs6040630 Imputed A REC 441 34 80 76 24 108 119 rs6040633 Imputed A ADD 442 34 80 76 24 109 119 rs6040633 Imputed A GEN 442 34 80 76 24 109 119 rs6040633 Imputed A REC 442 34 80 76 24 109 119 rs6040634 Imputed T ADD 441 34 81 75 24 109 118 rs6040634 Imputed T GEN 441 34 81 75 24 109 118 rs6040634 Imputed T REC 441 34 81 75 24 109 118 rs6040636 Imputed T ADD 443 34 79 78 24 109 119 rs6040636 Imputed T GEN 443 34 79 78 24 109 119 rs6040636 Imputed T REC 443 34 79 78 24 109 119 rs6040638 Imputed C ADD 443 34 80 77 24 109 119 rs6040638 Imputed C GEN 443 34 80 77 24 109 119 rs6040638 Imputed C REC 443 34 80 77 24 109 119 rs6040644 Imputed A ADD 443 34 80 77 24 109 119 rs6040644 Imputed A GEN 443 34 80 77 24 109 119 rs6040644 Imputed A REC 443 34 80 77 24 109 119 rs6040667 Imputed T ADD 424 34 79 69 24 108 110 rs6040667 Imputed T GEN 424 34 79 69 24 108 110 rs6040667 Imputed T REC 424 34 79 69 24 108 110 rs6040668 Imputed C ADD 440 33 82 75 23 111 116 rs6040668 Imputed C GEN 440 33 82 75 23 111 116 rs6040668 Imputed C REC 440 33 82 75 23 111 116 rs6043066 Genotyped G DOM 443 10 85 96 16 87 149 rs6048146 Imputed G DOM 443 0 19 172 2 11 239 rs6082725 Genotyped T DOM 443 0 19 172 2 11 239 rs6131206 Imputed C ADD 424 23 75 86 15 87 138 rs6131208 Imputed T ADD 440 33 79 77 23 109 119 rs6131208 Imputed T GEN 440 33 79 77 23 109 119 rs6131208 Imputed T REC 440 33 79 77 23 109 119 rs6134243 Imputed C ADD 443 34 80 77 24 109 119 rs6134243 Imputed C GEN 443 34 80 77 24 109 119 rs6134243 Imputed C REC 443 34 80 77 24 109 119 rs6136020 Imputed A DOM 441 8 49 134 8 64 178 rs613799 Imputed C DOM 420 26 78 77 24 93 122 rs644041 Imputed G ADD 402 11 77 83 16 87 128 rs644041 Imputed G DOM 402 11 77 83 16 87 128 rs647645 Imputed C ADD 441 37 87 66 44 135 72 rs647645 Imputed C GEN 441 37 87 66 44 135 72 rs647645 Imputed C REC 441 37 87 66 44 135 72 rs6495554 Imputed C GEN 443 13 64 114 9 81 162 rs6495554 Imputed C REC 443 13 64 114 9 81 162 rs6495555 Imputed C GEN 443 13 64 114 9 81 162 rs6495555 Imputed C REC 443 13 64 114 9 81 162 rs6544728 Imputed T DOM 439 10 81 97 21 84 146 rs6550705 Imputed C ADD 443 19 86 86 28 103 121 rs6550705 Imputed C GEN 443 19 86 86 28 103 121 rs6550707 Imputed T GEN 442 20 91 80 30 105 116 rs658108 Imputed A DOM 443 26 78 87 22 96 134 rs6593441 Imputed A DOM 412 0 50 129 3 48 182 rs668732 Imputed A DOM 442 46 95 50 49 137 65 rs671041 Imputed A DOM 443 26 78 87 22 96 134 rs6719700 Imputed A ADD 434 8 68 113 10 64 171 rs6719700 Imputed A DOM 434 8 68 113 10 64 171 rs6722640 Imputed T DOM 441 37 81 73 57 125 68 rs6743092 Imputed T ADD 434 59 80 48 50 138 59 rs6743092 Imputed T GEN 434 59 80 48 50 138 59 rs6743092 Imputed T REC 434 59 80 48 50 138 59 rs6744759 Imputed G REC 436 29 77 82 16 108 124 rs6746170 Imputed A DOM 442 11 84 96 21 86 144 rs6759922 Imputed A DOM 408 31 93 50 43 120 71 rs6769864 Imputed T GEN 436 19 86 82 28 102 119 rs6773932 Imputed C GEN 436 20 93 75 32 105 111 rs6774353 Imputed A GEN 443 19 86 86 28 103 121 rs6781670 Imputed C GEN 443 20 83 88 28 103 121 rs6786431 Imputed A GEN 436 20 93 75 32 105 111 rs6789091 Imputed T GEN 436 20 93 75 32 105 111 rs6791296 Imputed T ADD 426 1 36 143 2 70 174 rs6792662 Imputed G DOM 434 70 78 39 80 100 67 rs6797574 Imputed G GEN 436 20 93 75 32 105 111 rs6797882 Imputed G GEN 436 20 93 75 32 105 111 rs6805139 Imputed G DOM 442 67 81 43 76 101 74 rs6806043 Imputed C ADD 441 19 86 86 28 102 120 rs6806043 Imputed C GEN 441 19 86 86 28 102 120 rs6850716 Imputed C GEN 443 9 62 120 15 93 144 rs6867153 Imputed A REC 434 43 84 60 49 130 68 rs687047 Imputed C ADD 443 0 32 159 5 60 187 rs6871041 Imputed G DOM 418 16 62 104 15 112 109 rs688358 Imputed A ADD 427 0 32 154 5 58 178 rs6888012 Imputed A REC 432 43 84 59 49 129 68 rs6908481 Imputed C REC 400 35 78 58 37 113 79 rs7032231 Imputed A ADD 423 31 74 77 20 95 126 rs7067638 Imputed T DOM 442 0 51 139 3 49 200 rs7077799 Imputed A DOM 442 29 83 79 27 101 123 rs7082163 Imputed A ADD 440 0 49 139 4 47 201 rs7082163 Imputed A DOM 440 0 49 139 4 47 201 rs7089661 Imputed C DOM 442 28 84 79 25 103 123 rs7101319 Imputed C ADD 431 0 50 136 4 46 195 rs7101319 Imputed C DOM 431 0 50 136 4 46 195 rs710832 Genotyped A GEN 443 6 70 115 17 101 134 rs710832 Genotyped A REC 443 6 70 115 17 101 134 rs7134262 Imputed T GEN 438 29 85 76 21 111 116 rs7134262 Imputed T REC 438 29 85 76 21 111 116 rs7134671 Imputed T GEN 443 29 97 65 38 114 100 rs7138300 Imputed C ADD 432 30 90 65 63 116 68 rs7138300 Imputed C DOM 432 30 90 65 63 116 68 rs7138300 Imputed C GEN 432 30 90 65 63 116 68 rs7163931 Imputed G GEN 443 13 64 114 9 81 162 rs7163931 Imputed G REC 443 13 64 114 9 81 162 rs7171486 Genotyped G DOM 443 15 84 92 39 123 90 rs7172611 Imputed G GEN 443 13 64 114 9 81 162 rs7172611 Imputed G REC 443 13 64 114 9 81 162 rs7172689 Imputed T GEN 443 13 64 114 9 81 162 rs7172689 Imputed T REC 443 13 64 114 9 81 162 rs7175701 Imputed C GEN 440 14 68 107 10 90 151 rs7180245 Imputed A GEN 443 13 64 114 9 81 162 rs7180245 Imputed A REC 443 13 64 114 9 81 162 rs7220603 Genotyped A ADD 443 19 92 80 17 103 132 rs7282518 Imputed T ADD 387 3 46 113 5 58 162 rs7283476 Imputed T ADD 441 1 8 182 1 29 220 rs7283476 Imputed T DOM 441 1 8 182 1 29 220 rs7295817 Imputed C GEN 424 23 93 66 55 114 73 rs7298255 Imputed A ADD 443 34 92 65 67 115 70 rs7298255 Imputed A DOM 443 34 92 65 67 115 70 rs7305832 Imputed C GEN 442 29 85 77 21 112 118 rs7305832 Imputed C REC 442 29 85 77 21 112 118 rs7331467 Imputed A GEN 443 19 89 83 35 112 105 rs7392620 Imputed C ADD 437 12 74 103 32 110 106 rs742827 Imputed A ADD 437 33 82 75 23 109 115 rs742827 Imputed A GEN 437 33 82 75 23 109 115 rs742827 Imputed A REC 437 33 82 75 23 109 115 rs7446891 Imputed G DOM 443 27 65 99 33 119 100 rs7448641 Imputed C ADD 443 3 22 166 7 23 222 rs7448641 Imputed C DOM 443 3 22 166 7 23 222 rs7484728 Imputed T GEN 443 29 97 65 38 114 100 rs7499402 Genotyped A ADD 443 0 34 157 1 22 229 rs7529851 Imputed A ADD 401 22 76 70 49 108 76 rs7529851 Imputed A GEN 401 22 76 70 49 108 76 rs7573951 Imputed G ADD 442 36 96 59 55 110 86 rs7599198 Imputed T DOM 371 30 87 44 41 113 56 rs7600050 Imputed C ADD 416 27 84 70 24 103 108 rs7607712 Imputed T ADD 441 9 69 113 10 69 171 rs7607712 Imputed T DOM 441 9 69 113 10 69 171 rs7613492 Imputed G GEN 443 19 86 86 28 103 121 rs7621663 Imputed G ADD 443 19 86 86 28 103 121 rs7621663 Imputed G GEN 443 19 86 86 28 103 121 rs7621663 Imputed G REC 443 19 86 86 28 103 121 rs7626584 Imputed G ADD 442 0 18 173 1 31 219 rs7684899 Imputed C ADD 417 6 37 139 7 81 147 rs7684899 Imputed C DOM 417 6 37 139 7 81 147 rs7701604 Imputed G ADD 443 3 22 166 7 23 222 rs7701604 Imputed G DOM 443 3 22 166 7 23 222 rs7703676 Imputed C ADD 443 3 22 166 7 23 222 rs7703676 Imputed C DOM 443 3 22 166 7 23 222 rs7708491 Imputed C REC 435 43 84 60 50 130 68 rs7711358 Imputed A DOM 443 26 66 99 34 118 100 rs7719448 Imputed G REC 436 44 84 60 49 130 69 rs7724761 Imputed T REC 435 43 84 60 49 131 68 rs7742476 Imputed T DOM 386 7 72 90 4 86 127 rs7762993 Imputed A ADD 431 2 65 119 3 82 160 rs7762993 Imputed A DOM 431 2 65 119 3 82 160 rs7767265 Imputed G ADD 430 9 79 99 7 99 137 rs7767265 Imputed G DOM 430 9 79 99 7 99 137 rs7768128 Imputed G REC 439 5 76 108 19 76 155 rs7771264 Imputed T DOM 441 14 67 108 18 88 146 rs7773151 Genotyped C DOM 443 10 65 116 16 82 154 rs7773210 Genotyped A DOM 443 10 65 116 16 82 154 rs7808536 Imputed G DOM 409 8 59 112 7 63 160 rs7843510 Genotyped G DOM 443 40 84 67 47 117 88 rs7894867 Imputed T DOM 441 0 51 138 3 49 200 rs7921834 Imputed C DOM 440 28 83 79 26 101 123 rs7939893 Imputed C ADD 441 22 62 106 29 124 98 rs7939893 Imputed C DOM 441 22 62 106 29 124 98 rs7944513 Imputed T GEN 418 17 66 96 14 77 148 rs7944513 Imputed T REC 418 17 66 96 14 77 148 rs7949720 Imputed G ADD 418 3 45 137 2 42 189 rs7949720 Imputed G DOM 418 3 45 137 2 42 189 rs7955901 Imputed C ADD 440 34 91 65 67 115 68 rs7955901 Imputed C DOM 440 34 91 65 67 115 68 rs7956274 Imputed T ADD 426 30 88 64 63 113 68 rs7956274 Imputed T DOM 426 30 88 64 63 113 68 rs7956274 Imputed T GEN 426 30 88 64 63 113 68 rs7957932 Imputed G ADD 439 35 92 64 67 117 64 rs7957932 Imputed G DOM 439 35 92 64 67 117 64 rs7984504 Imputed C GEN 443 19 79 93 30 103 119 rs7999518 Imputed A REC 423 29 99 51 74 117 53 rs8026245 Imputed G GEN 442 14 69 108 10 90 151 rs8026245 Imputed G REC 442 14 69 108 10 90 151 rs8060725 Genotyped A ADD 443 11 63 117 18 112 122 rs8103016 Genotyped A ADD 443 11 72 108 14 78 160 rs8103016 Genotyped A DOM 443 11 72 108 14 78 160 rs8104182 Imputed G ADD 440 10 71 108 11 77 163 rs8104182 Imputed G DOM 440 10 71 108 11 77 163 rs8129461 Imputed G ADD 441 1 8 182 1 32 217 rs8129461 Imputed G DOM 441 1 8 182 1 32 217 rs8130021 Imputed G ADD 442 1 8 182 1 29 221 rs8130021 Imputed G DOM 442 1 8 182 1 29 221 rs879961 Imputed T ADD 440 13 87 90 16 103 131 rs879961 Imputed T DOM 440 13 87 90 16 103 131 rs906353 Imputed A DOM 434 16 86 84 22 103 123 rs915491 Imputed C DOM 441 28 76 86 21 98 132 rs915493 Imputed T DOM 441 28 76 86 21 98 132 rs915494 Imputed A ADD 422 29 79 78 22 91 123 rs915494 Imputed A DOM 422 29 79 78 22 91 123 rs917295 Imputed G DOM 443 27 65 99 33 119 100 rs9284851 Imputed A GEN 436 20 93 75 32 105 111 rs9293464 Imputed T REC 435 43 84 60 49 131 68 rs9295154 Genotyped G DOM 443 3 53 135 9 47 196 rs9310221 Imputed A DOM 393 29 86 54 36 121 67 rs9310699 Genotyped T GEN 443 20 83 88 28 103 121 rs9310700 Imputed C ADD 443 19 86 86 28 103 121 rs9310700 Imputed C GEN 443 19 86 86 28 103 121 rs9310701 Imputed G GEN 443 20 91 80 30 105 117 rs9310704 Imputed G GEN 436 20 93 75 32 105 111 rs9319185 Imputed C GEN 441 17 79 93 30 103 119 rs9319186 Imputed T GEN 443 19 79 93 30 103 119 rs9327555 Imputed T DOM 443 27 65 99 33 119 100 rs9403367 Imputed C DOM 443 10 65 116 16 82 154 rs9419608 Imputed G REC 430 28 94 61 57 130 60 rs9426437 Imputed T DOM 424 33 96 57 40 123 75 rs9454967 Imputed G DOM 441 3 28 159 4 38 209 rs9635511 Imputed T DOM 436 26 96 67 47 119 81 rs966583 Imputed A ADD 439 26 87 77 44 125 80 rs966583 Imputed A DOM 439 26 87 77 44 125 80 rs980263 Imputed T GEN 443 20 91 80 30 105 117 rs980264 Imputed T GEN 443 20 91 80 30 105 117 rs9812206 Imputed G ADD 442 0 30 161 0 38 213 rs9812206 Imputed G DOM 442 0 30 161 0 38 213 rs9813552 Imputed G ADD 442 0 30 161 1 36 214 rs9813552 Imputed G DOM 442 0 30 161 1 36 214 rs9815037 Imputed T ADD 443 0 30 161 1 36 215 rs9815037 Imputed T DOM 443 0 30 161 1 36 215 rs9819583 Imputed T GEN 443 20 83 88 28 103 121 rs9825349 Imputed A ADD 443 0 30 161 1 36 215 rs9825349 Imputed A DOM 443 0 30 161 1 36 215 rs9833118 Imputed G ADD 443 19 86 86 28 103 121 rs9833118 Imputed G GEN 443 19 86 86 28 103 121 rs9834217 Imputed T ADD 443 0 30 161 1 37 214 rs9834217 Imputed T DOM 443 0 30 161 1 37 214 rs9838563 Imputed C GEN 437 20 89 80 28 104 116 rs9840460 Imputed T ADD 443 0 30 161 1 37 214 rs9840460 Imputed T DOM 443 0 30 161 1 37 214 rs9840756 Imputed A ADD 437 0 30 160 1 37 209 rs9840756 Imputed A DOM 437 0 30 160 1 37 209 rs9847999 Imputed C GEN 436 20 93 75 32 105 111 rs9864769 Imputed C GEN 443 20 91 80 30 105 117 rs9866421 Genotyped C REC 443 29 94 68 57 111 84 rs987296 Imputed T GEN 441 20 83 88 28 102 120 rs9881685 Imputed A ADD 440 0 30 160 0 38 212 rs9881685 Imputed A DOM 440 0 30 160 0 38 212 rs992695 Imputed C ADD 442 13 87 90 16 105 131 rs992695 Imputed C DOM 442 13 87 90 16 105 131 rs9936999 Imputed G DOM 266 20 40 52 18 74 62

TABLE 17 SNP rs # SOURCE ALLELE (A1) MODEL P P(R) OR OR(R) Q I rs77638540 Genotyped T DOMINANT 2.65E−03 0.0159 0.4686 0.4785 0.2317 30.09 rs72746987 Genotyped A DOMINANT 3.12E−05 3.12E−05 0.337 0.337 0.9734 0 rs10021016 Genotyped G GENOTYPIC 4.88E−04 0.000488 2.3201 2.3201 0.9885 0 rs10021016 Genotyped G RECESSIVE 7.69E−04 0.0007685 2.2102 2.2102 0.9334 0 rs10051148 Imputed C DOMINANT 0.000697 0.000697 0.6715 0.6715 0.7678 0 rs10054055 Imputed T DOMINANT 0.0008519 0.0008519 0.6758 0.6758 0.8098 0 rs10067895 Imputed A DOMINANT 9.99E−04 0.0009994 0.6775 0.6775 0.9204 0 rs10100725 Imputed C DOMINANT 5.54E−05 5.54E−05 0.5929 0.5929 0.3989 0 rs10128531 Imputed T ADDITIVE 1.54E−03 0.001541 1.4677 1.4677 0.921 0 rs10181743 Imputed G ADDITIVE 9.76E−05 9.76E−05 1.4004 1.4004 0.3524 0 rs10199127 Imputed T DOMINANT 4.59E−05 4.59E−05 1.6169 1.6169 0.3286 0 rs10270624 Imputed G DOMINANT 2.16E−04 0.0003017 1.5776 1.5804 0.3061 4.53 rs1030006 Imputed G RECESSIVE 7.93E−05 7.93E−05 1.7557 1.7557 0.577 0 rs1031811 Imputed A RECESSIVE 6.16E−03 0.006159 1.7624 1.7624 0.7766 0 rs10430870 Genotyped G GENOTYPIC 3.07E−03 3.07E−03 2.094 2.094 0.4823 0 rs10430870 Genotyped G RECESSIVE 0.003991 0.003991 2.0223 2.0223 0.6273 0 rs10469597 Imputed A GENOTYPIC 4.70E−05 4.70E−05 2.5398 2.5398 0.9742 0 rs10469597 Imputed A RECESSIVE 4.85E−05 4.85E−05 2.4663 2.4663 0.8923 0 rs10478919 Imputed G DOMINANT 5.77E−04 0.0005772 0.6679 0.6679 0.7414 0 rs10506623 Imputed C ADDITIVE 0.0001433 0.0001433 0.7177 0.7177 0.7038 0 rs10506623 Imputed C DOMINANT 8.28E−05 8.28E−05 0.6159 0.6159 0.9559 0 rs10506626 Imputed A ADDITIVE 7.58E−05 7.58E−05 0.7112 0.7112 0.422 0 rs10506626 Imputed A DOMINANT 8.52E−06 8.52E−06 0.5838 0.5838 0.8702 0 rs10509477 Imputed T DOMINANT 8.97E−05 8.97E−05 1.5819 1.5819 0.6066 0 rs10517918 Imputed G RECESSIVE 6.05E−05 6.05E−05 1.8264 1.8264 0.4972 0 rs10517924 Imputed A RECESSIVE 7.80E−05 7.80E−05 1.7459 1.7459 0.7576 0 rs10519362 Imputed G DOMINANT 0.001678 0.001678 1.4934 1.4934 0.9592 0 rs10520072 Imputed T DOMINANT 0.0005579 0.0005579 0.6664 0.6664 0.9359 0 rs10737390 Imputed T DOMINANT 5.50E−05 5.50E−05 0.6131 0.6131 0.5051 0 rs10742851 Imputed T RECESSIVE 9.69E−05 9.69E−05 0.3726 0.3726 0.5568 0 rs10743685 Imputed G GENOTYPIC 6.86E−05 6.86E−05 2.0019 2.0019 0.8416 0 rs10743685 Imputed G RECESSIVE 1.49E−04 0.0001485 1.8297 1.8297 0.5748 0 rs10749293 Imputed G DOMINANT 6.75E−05 6.75E−05 1.5947 1.5947 0.7622 0 rs10749294 Imputed A DOMINANT 1.82E−04 1.82E−04 1.55 1.55 0.8529 0 rs10753760 Imputed T ADDITIVE 5.13E−05 5.13E−05 1.4174 1.4174 0.7656 0 rs10753760 Imputed T GENOTYPIC 5.49E−05 5.49E−05 2.0466 2.0466 0.7902 0 rs10772362 Imputed T ADDITIVE 1.62E−05 1.62E−05 0.6474 0.6474 0.7786 0 rs10784891 Imputed C ADDITIVE 3.04E−04 0.0003039 0.7309 0.7309 0.7572 0 rs10784891 Imputed C DOMINANT 1.43E−04 1.43E−04 0.6151 0.6151 0.793 0 rs10784891 Imputed C GENOTYPIC 1.13E−03 1.13E−03 0.564 0.564 0.5692 0 rs10787923 Imputed G DOMINANT 6.49E−05 6.49E−05 1.5969 1.5969 0.7212 0 rs10787924 Imputed T DOMINANT 1.60E−04 0.0001596 1.5563 1.5563 0.8327 0 rs10787949 Imputed A DOMINANT 0.0001459 0.0001459 1.5599 1.5599 0.592 0 rs10787951 Imputed G DOMINANT 0.0001459 0.0001459 1.5599 1.5599 0.592 0 rs10787983 Imputed C DOMINANT 0.0001474 0.0001474 1.5574 1.5574 0.6777 0 rs10794733 Imputed C ADDITIVE 0.00276 0.00276 0.7628 0.7628 0.9657 0 rs10818280 Imputed C DOMINANT 1.66E−03 0.00166 0.6922 0.6922 0.8399 0 rs10860586 Imputed A ADDITIVE 9.56E−05 9.56E−05 1.3855 1.3855 0.4436 0 rs10860586 Imputed A GENOTYPIC 9.35E−05 9.35E−05 1.9196 1.9196 0.4483 0 rs10870473 Imputed A ADDITIVE 9.61E−05 9.61E−05 0.569 0.569 0.6419 0 rs10870473 Imputed A DOMINANT 3.52E−05 3.52E−05 0.4776 0.4776 0.9449 0 rs10879240 Imputed C ADDITIVE 5.56E−04 0.0005557 0.7439 0.7439 0.8062 0 rs10879240 Imputed C GENOTYPIC 0.001627 0.001627 0.5771 0.5771 0.5726 0 rs10879242 Imputed A ADDITIVE 2.20E−04 0.0002198 0.7269 0.7269 0.7534 0 rs10879242 Imputed A DOMINANT 7.97E−05 7.97E−05 0.6177 0.6177 0.8661 0 rs10879245 Imputed G ADDITIVE 2.20E−04 0.0002198 0.7269 0.7269 0.7534 0 rs10879245 Imputed G DOMINANT 7.97E−05 7.97E−05 0.6177 0.6177 0.8661 0 rs10879249 Imputed T ADDITIVE 7.98E−05 7.98E−05 0.7098 0.7098 0.7061 0 rs10879249 Imputed T DOMINANT 3.54E−05 3.54E−05 0.6036 0.6036 0.9476 0 rs10886429 Imputed A DOMINANT 1.10E−04 1.10E−04 1.5741 1.5741 0.6665 0 rs10886449 Imputed G DOMINANT 0.0002256 0.0002256 1.5385 1.5385 0.68 0 rs10886451 Imputed G DOMINANT 2.26E−04 0.0002256 1.5385 1.5385 0.68 0 rs10886452 Imputed A DOMINANT 0.0001459 0.0001459 1.5599 1.5599 0.592 0 rs10886456 Imputed G DOMINANT 0.0002256 0.0002256 1.5385 1.5385 0.68 0 rs10886463 Imputed C DOMINANT 0.0001545 0.0001545 1.5578 1.5578 0.6315 0 rs10886465 Imputed A DOMINANT 8.63E−05 8.63E−05 1.5827 1.5827 0.5622 0 rs10886526 Imputed C DOMINANT 1.47E−04 0.0001474 1.5574 1.5574 0.6777 0 rs10922903 Imputed C RECESSIVE 9.19E−05 9.19E−05 0.5329 0.5329 0.4609 0 rs10941126 Imputed G ADDITIVE 1.27E−05 1.27E−05 0.2451 0.2451 0.6218 0 rs10941126 Imputed G DOMINANT 2.81E−05 2.81E−05 0.2509 0.2509 0.6535 0 rs10947980 Imputed G ADDITIVE 7.93E−05 7.93E−05 0.6897 0.6897 0.3212 0 rs11059376 Imputed T ADDITIVE 5.53E−05 5.53E−05 1.5704 1.5704 0.929 0 rs11072995 Imputed T GENOTYPIC 0.0002433 0.0002433 3.2596 3.2596 0.6428 0 rs11072995 Imputed T RECESSIVE 0.0003025 0.0003025 3.164 3.164 0.6989 0 rs11081202 Genotyped G GENOTYPIC 2.03E−03 0.002028 1.979 1.979 0.4228 0 rs11081202 Genotyped G RECESSIVE 5.63E−04 0.0005629 2.0891 2.0891 0.5637 0 rs110965 Imputed C GENOTYPIC 6.88E−03 6.88E−03 1.7493 1.7493 0.9979 0 rs11124962 Imputed A DOMINANT 0.000116 0.000116 1.5786 1.5786 0.4004 0 rs1116596 Imputed T DOMINANT 6.74E−04 0.000674 0.6707 0.6707 0.7616 0 rs11178531 Imputed A ADDITIVE 1.67E−03 1.67E−03 0.7662 0.7662 0.8942 0 rs11178531 Imputed A DOMINANT 2.00E−04 0.0001996 0.6214 0.6214 0.9419 0 rs11178583 Imputed A ADDITIVE 8.27E−05 8.27E−05 0.7104 0.7104 0.7004 0 rs11178583 Imputed A DOMINANT 3.96E−05 3.96E−05 0.6056 0.6056 0.9636 0 rs11178589 Imputed T ADDITIVE 6.68E−05 6.68E−05 0.7079 0.7079 0.7072 0 rs11178589 Imputed T DOMINANT 3.53E−05 3.53E−05 0.6015 0.6015 0.9599 0 rs11178594 Imputed C ADDITIVE 0.0001049 0.0001049 0.7148 0.7148 0.7211 0 rs11178594 Imputed C DOMINANT 4.13E−05 4.13E−05 0.6065 0.6065 0.8956 0 rs11178602 Imputed T ADDITIVE 8.81E−05 8.81E−05 0.7122 0.7122 0.7436 0 rs11178602 Imputed T DOMINANT 3.05E−05 3.05E−05 0.6016 0.6016 0.8568 0 rs11178648 Imputed T ADDITIVE 0.0002031 0.0002031 0.7267 0.7267 0.6332 0 rs11178648 Imputed T DOMINANT 1.72E−05 1.72E−05 0.5945 0.5945 0.939 0 rs11198877 Imputed T DOMINANT 1.33E−04 0.0001326 1.5641 1.5641 0.6136 0 rs11198942 Imputed T DOMINANT 8.97E−05 8.97E−05 1.5819 1.5819 0.6066 0 rs11221075 Imputed A ADDITIVE 0.002129 0.002129 0.6684 0.6684 0.6989 0 rs11242020 Imputed T DOMINANT 0.0005976 0.0005976 0.6685 0.6685 0.6979 0 rs11242021 Imputed T DOMINANT 0.000699 0.000699 0.6712 0.6712 0.8706 0 rs11242022 Imputed T DOMINANT 0.0007669 0.0007669 0.6732 0.6732 0.8443 0 rs11242023 Imputed T DOMINANT 0.0009289 0.0009289 0.677 0.677 0.8728 0 rs1149349 Imputed T DOMINANT 7.39E−05 7.39E−05 1.6656 1.6656 0.8419 0 rs1149350 Imputed A ADDITIVE 1.42E−05 1.42E−05 1.5752 1.5752 0.893 0 rs1149350 Imputed A DOMINANT 5.15E−06 5.15E−06 1.7451 1.7451 0.7691 0 rs11576627 Imputed T ADDITIVE 0.0002162 0.0002162 1.5806 1.5806 0.4132 0 rs11576627 Imputed T DOMINANT 1.75E−04 0.0001751 1.6594 1.6594 0.4028 0 rs11630050 Imputed G GENOTYPIC 0.0001769 0.0001769 3.0849 3.0849 0.8542 0 rs11630050 Imputed G RECESSIVE 0.0001739 0.0001739 3.0436 3.0436 0.9473 0 rs11633024 Imputed C GENOTYPIC 0.0001769 0.0001769 3.0849 3.0849 0.8542 0 rs11633024 Imputed C RECESSIVE 0.0001739 0.0001739 3.0436 3.0436 0.9473 0 rs11636298 Imputed G GENOTYPIC 0.0001106 0.0001106 3.4591 3.4591 0.8474 0 rs11636298 Imputed G RECESSIVE 0.0001586 0.0001586 3.317 3.317 0.9056 0 rs11637363 Imputed C GENOTYPIC 0.0001099 0.0001099 3.1869 3.1869 0.7516 0 rs11637363 Imputed C RECESSIVE 0.0001027 0.0001027 3.1534 3.1534 0.8534 0 rs11637813 Imputed A GENOTYPIC 0.0001769 0.0001769 3.0849 3.0849 0.8542 0 rs11637813 Imputed A RECESSIVE 0.0001739 0.0001739 3.0436 3.0436 0.9473 0 rs11638043 Imputed C GENOTYPIC 1.79E−04 0.0001788 3.0118 3.0118 0.8819 0 rs11638043 Imputed C RECESSIVE 0.0001717 0.0001717 2.9756 2.9756 0.9909 0 rs11638115 Imputed A GENOTYPIC 0.0002433 0.0002433 3.2596 3.2596 0.6428 0 rs11638115 Imputed A RECESSIVE 0.0003025 0.0003025 3.164 3.164 0.6989 0 rs11638444 Imputed C GENOTYPIC 0.0001194 0.0001194 3.4378 3.4378 0.8647 0 rs11717157 Imputed T ADDITIVE 8.91E−05 8.91E−05 1.3969 1.3969 0.7348 0 rs11717157 Imputed T GENOTYPIC 5.30E−05 5.30E−05 2.0995 2.0995 0.9749 0 rs11724055 Imputed A DOMINANT 0.00239 0.00239 0.6839 0.6839 0.4246 0 rs11743355 Imputed C ADDITIVE 1.64E−05 1.64E−05 0.2366 0.2366 0.5626 0 rs11743355 Imputed C DOMINANT 3.44E−05 3.44E−05 0.2417 0.2417 0.589 0 rs11746806 Imputed T ADDITIVE 1.27E−05 1.27E−05 0.2451 0.2451 0.6218 0 rs11746806 Imputed T DOMINANT 2.81E−05 2.81E−05 0.2509 0.2509 0.6535 0 rs11746959 Imputed T ADDITIVE 1.27E−05 1.27E−05 0.2451 0.2451 0.6218 0 rs11746959 Imputed T DOMINANT 2.81E−05 2.81E−05 0.2509 0.2509 0.6535 0 rs11749272 Imputed T DOMINANT 0.0005772 0.0005772 0.6679 0.6679 0.7414 0 rs11839636 Imputed C GENOTYPIC 7.59E−05 7.59E−05 2.2506 2.2506 0.9705 0 rs11839785 Imputed C GENOTYPIC 7.97E−05 7.97E−05 2.2456 2.2456 0.9638 0 rs11853619 Imputed C GENOTYPIC 0.0001175 0.0001175 3.4406 3.4406 0.8594 0 rs11853619 Imputed C RECESSIVE 0.0001702 0.0001702 3.2975 3.2975 0.9191 0 rs11856780 Imputed A GENOTYPIC 0.0001175 0.0001175 3.4406 3.4406 0.8594 0 rs11856780 Imputed A RECESSIVE 0.0001702 0.0001702 3.2975 3.2975 0.9191 0 rs11901899 Imputed A DOMINANT 3.44E−04 0.001093 1.5287 1.539 0.2722 17.07 rs11903290 Imputed C RECESSIVE 0.006295 0.006295 1.7598 1.7598 0.7724 0 rs11909480 Imputed G ADDITIVE 0.001521 0.001521 0.4399 0.4399 0.3262 0 rs11909480 Imputed G DOMINANT 0.001914 0.001964 0.4405 0.4406 0.3163 0.41 rs11910289 Imputed T ADDITIVE 0.001496 0.001496 1.8584 1.8584 0.5088 0 rs11910289 Imputed T DOMINANT 0.001453 0.001453 1.9004 1.9004 0.599 0 rs11920375 Genotyped C GENOTYPIC 7.94E−05 7.94E−05 2.0435 2.0435 0.8995 0 rs11926319 Imputed G DOMINANT 9.79E−05 9.79E−05 0.5435 0.5435 0.854 0 rs11933744 Imputed T RECESSIVE 9.01E−05 9.01E−05 2.5682 2.5682 0.6941 0 rs11934919 Imputed C RECESSIVE 9.01E−05 9.01E−05 2.5682 2.5682 0.6941 0 rs11934957 Imputed C RECESSIVE 9.01E−05 9.01E−05 2.5682 2.5682 0.6941 0 rs11959206 Imputed A RECESSIVE 3.66E−05 3.66E−05 0.5455 0.5455 0.7414 0 rs12038613 Imputed C RECESSIVE 7.06E−05 7.06E−05 0.5252 0.5252 0.5509 0 rs12151417 Imputed T DOMINANT 6.45E−04 0.0006449 1.5021 1.5021 0.7699 0 rs12153185 Imputed T DOMINANT 0.001052 0.001052 0.6792 0.6792 0.8684 0 rs12182651 Imputed T DOMINANT 5.94E−05 5.94E−05 1.9576 1.9576 0.6125 0 rs12235345 Imputed C DOMINANT 3.59E−04 0.005622 1.8464 1.8177 0.2149 34.98 rs12324786 Imputed T GENOTYPIC 0.0002433 0.0002433 3.2596 3.2596 0.6428 0 rs12324786 Imputed T RECESSIVE 0.0003025 0.0003025 3.164 3.164 0.6989 0 rs12336958 Imputed G DOMINANT 7.27E−05 7.27E−05 1.6549 1.6549 0.457 0 rs12407412 Imputed C ADDITIVE 0.0002548 0.0002548 1.5719 1.5719 0.384 0 rs12407412 Imputed C DOMINANT 2.10E−04 2.10E−04 1.6487 1.6487 0.368 0 rs12418971 Imputed C GENOTYPIC 0.001802 0.001802 2.2011 2.2011 0.4612 0 rs12418971 Imputed C RECESSIVE 0.002813 0.002813 2.095 2.095 0.5916 0 rs1241967 Imputed T RECESSIVE 0.000111 0.000111 0.4573 0.4573 0.3307 0 rs12420184 Imputed G DOMINANT 4.91E−05 4.91E−05 0.5847 0.5847 0.5393 0 rs12433968 Imputed T DOMINANT 4.10E−05 4.10E−05 0.6109 0.6109 0.318 0 rs12445477 Imputed A DOMINANT 6.95E−05 6.95E−05 0.5027 0.5027 0.3771 0 rs12447191 Genotyped T ADDITIVE 0.0002095 0.0002095 0.6717 0.6717 0.8037 0 rs12447191 Genotyped T DOMINANT 2.32E−04 0.004396 0.6338 0.6204 0.1898 41.82 rs12465349 Imputed A RECESSIVE 0.00192 0.00192 1.513 1.513 0.7914 0 rs1247340 Imputed C ADDITIVE 5.07E−05 5.07E−05 1.5296 1.5296 0.9256 0 rs1247340 Imputed C DOMINANT 1.08E−05 1.08E−05 1.7083 1.7083 0.8426 0 rs1247341 Imputed C ADDITIVE 5.04E−05 5.04E−05 1.5303 1.5303 0.9761 0 rs1247341 Imputed C DOMINANT 1.08E−05 1.08E−05 1.7098 1.7098 0.7759 0 rs1247343 Imputed C DOMINANT 6.53E−05 6.53E−05 1.6756 1.6756 0.9862 0 rs12509758 Imputed C DOMINANT 0.0001489 0.0001489 1.5799 1.5799 0.3277 0 rs12515472 Imputed A DOMINANT 0.005408 0.005408 1.4022 1.4022 0.5945 0 rs12548906 Imputed G ADDITIVE 3.90E−03 3.90E−03 1.3761 1.3761 0.5561 0 rs12596240 Imputed G DOMINANT 4.46E−05 4.46E−05 0.6107 0.6107 0.5739 0 rs12618781 Imputed A DOMINANT 5.33E−05 5.33E−05 0.5924 0.5924 0.6396 0 rs12678600 Imputed A DOMINANT 5.58E−05 5.58E−05 0.6235 0.6235 0.8084 0 rs12692229 Imputed T ADDITIVE 5.68E−03 0.005681 1.271 1.271 0.7737 0 rs12713324 Imputed T DOMINANT 0.0005653 0.0005653 1.5061 1.5061 0.7503 0 rs12719415 Imputed T DOMINANT 6.99E−04 6.99E−04 0.6712 0.6712 0.8706 0 rs12820589 Imputed G ADDITIVE 3.73E−05 3.73E−05 1.5773 1.5773 0.4594 0 rs12820589 Imputed G DOMINANT 8.50E−05 8.50E−05 1.6354 1.6354 0.3309 0 rs12831292 Imputed G ADDITIVE 1.08E−04 0.0001082 0.7143 0.7143 0.7244 0 rs12831292 Imputed G DOMINANT 3.86E−05 3.86E−05 0.6038 0.6038 0.8742 0 rs13012636 Imputed G RECESSIVE 0.005887 0.005887 1.7676 1.7676 0.7851 0 rs13038146 Imputed C ADDITIVE 0.0001909 0.0001909 1.3722 1.3722 0.8246 0 rs13038146 Imputed C GENOTYPIC 0.0002206 0.0002206 1.9531 1.9531 0.7476 0 rs13038146 Imputed C RECESSIVE 0.00156 0.00156 1.7021 1.7021 0.4049 0 rs13089860 Imputed A DOMINANT 0.001151 0.001151 0.6379 0.6379 0.8916 0 rs13102419 Imputed T RECESSIVE 7.45E−05 7.45E−05 1.7512 1.7512 0.8001 0 rs13194907 Imputed A ADDITIVE 7.20E−05 7.20E−05 1.9871 1.9871 0.9631 0 rs13194907 Imputed A DOMINANT 4.88E−05 4.88E−05 2.0957 2.0957 0.9413 0 rs13195745 Imputed A ADDITIVE 7.54E−05 7.54E−05 1.9837 1.9837 0.9685 0 rs13195745 Imputed A DOMINANT 5.13E−05 5.13E−05 2.0917 2.0917 0.9353 0 rs13265054 Imputed T DOMINANT 0.0001224 0.0001224 0.6362 0.6362 0.7096 0 rs13273002 Imputed A GENOTYPIC 8.64E−05 8.64E−05 0.2714 0.2714 0.8433 0 rs13282131 Imputed C ADDITIVE 0.000217 0.000217 1.3612 1.3612 0.7192 0 rs13282131 Imputed C GENOTYPIC 0.00017 0.00017 1.8797 1.8797 0.7696 0 rs13282131 Imputed C RECESSIVE 0.0009795 0.0009795 1.6011 1.6011 0.9829 0 rs1330052 Imputed G GENOTYPIC 8.27E−05 8.27E−05 2.0747 2.0747 0.9516 0 rs1335721 Imputed A RECESSIVE 7.06E−05 7.06E−05 0.5252 0.5252 0.5509 0 rs1336382 Imputed T DOMINANT 9.54E−05 9.54E−05 1.5804 1.5804 0.6104 0 rs1336383 Imputed T DOMINANT 8.97E−05 8.97E−05 1.5819 1.5819 0.6066 0 rs1336407 Imputed T DOMINANT 1.35E−04 0.0001345 1.5612 1.5612 0.6665 0 rs1336409 Imputed T DOMINANT 0.0001345 0.0001345 1.5612 1.5612 0.6665 0 rs1336596 Imputed A DOMINANT 8.41E−06 8.41E−06 0.5875 0.5875 0.3994 0 rs13387284 Imputed A DOMINANT 4.10E−05 4.10E−05 0.5856 0.5856 0.5635 0 rs13401462 Imputed C DOMINANT 4.87E−06 4.87E−06 1.8734 1.8734 0.4869 0 rs13409045 Imputed T ADDITIVE 8.99E−05 8.99E−05 0.7108 0.7108 0.8294 0 rs1349284 Imputed C GENOTYPIC 7.91E−05 7.91E−05 2.0683 2.0683 0.8608 0 rs1355715 Imputed T ADDITIVE 0.0001691 0.0001691 0.5021 0.5021 0.6625 0 rs1357696 Imputed A GENOTYPIC 8.12E−05 8.12E−05 2.0503 2.0503 0.8139 0 rs1357698 Imputed A GENOTYPIC 7.29E−05 7.29E−05 2.0604 2.0604 0.7974 0 rs1357699 Imputed T GENOTYPIC 7.29E−05 7.29E−05 2.0604 2.0604 0.7974 0 rs1363273 Imputed C RECESSIVE 7.91E−05 7.91E−05 0.5543 0.5543 0.8284 0 rs1373601 Imputed A DOMINANT 6.34E−05 6.34E−05 0.6152 0.6152 0.3644 0 rs1375829 Imputed C GENOTYPIC 7.91E−05 7.91E−05 2.0683 2.0683 0.8608 0 rs1395748 Imputed G DOMINANT 7.51E−05 7.51E−05 0.6306 0.6306 0.7714 0 rs1414865 Imputed T DOMINANT 1.46E−04 0.0001459 1.5599 1.5599 0.592 0 rs1414873 Imputed A DOMINANT 0.0001345 0.0001345 1.5612 1.5612 0.6665 0 rs1414876 Imputed C DOMINANT 1.35E−04 1.35E−04 1.5612 1.5612 0.6665 0 rs1424643 Imputed G ADDITIVE 4.44E−04 0.0004437 1.4199 1.4199 0.4926 0 rs1424643 Imputed G DOMINANT 4.24E−04 0.0004238 1.5226 1.5226 0.7796 0 rs1424648 Imputed T DOMINANT 1.80E−03 1.80E−03 1.4456 1.4456 0.4734 0 rs1429321 Imputed A DOMINANT 7.84E−04 7.84E−04 1.4871 1.4871 0.8099 0 rs1429326 Imputed T ADDITIVE 0.0007358 0.0007358 1.3974 1.3974 0.5449 0 rs1429326 Imputed T DOMINANT 0.0004785 0.0004785 1.5125 1.5125 0.8054 0 rs1444741 Imputed A DOMINANT 3.42E−05 3.42E−05 0.605 0.605 0.3326 0 rs1449916 Imputed C DOMINANT 2.24E−05 2.52E−05 0.5247 0.5244 0.3143 1.22 rs1459523 Imputed A ADDITIVE 8.91E−05 8.91E−05 1.3969 1.3969 0.7348 0 rs1459523 Imputed A GENOTYPIC 5.30E−05 5.30E−05 2.0995 2.0995 0.9749 0 rs1466352 Imputed T GENOTYPIC 7.67E−05 7.67E−05 2.0358 2.0358 0.8969 0 rs1466353 Imputed G GENOTYPIC 7.61E−05 7.61E−05 2.0365 2.0365 0.898 0 rs1476714 Imputed A DOMINANT 0.0007134 0.0007134 0.6713 0.6713 0.8712 0 rs1486723 Imputed C RECESSIVE 0.0003279 0.0003279 0.4982 0.4982 0.4282 0 rs1495375 Imputed A ADDITIVE 0.0002198 0.0002198 0.7269 0.7269 0.7534 0 rs1495375 Imputed A DOMINANT 7.97E−05 7.97E−05 0.6177 0.6177 0.8661 0 rs1495381 Imputed T GENOTYPIC 0.00257 0.00257 1.6918 1.6918 0.6996 0 rs1495381 Imputed T RECESSIVE 0.0004641 0.0004641 1.7303 1.7303 0.8349 0 rs1498061 Imputed C ADDITIVE 1.30E−04 0.0001304 0.5363 0.5363 0.5167 0 rs1498992 Imputed G DOMINANT 1.21E−04 0.0001213 0.6388 0.6388 0.4443 0 rs1499001 Imputed T DOMINANT 4.88E−05 4.88E−05 0.6155 0.6155 0.3606 0 rs1512988 Imputed A ADDITIVE 8.41E−05 8.41E−05 0.7101 0.7101 0.6962 0 rs1512988 Imputed A DOMINANT 4.47E−05 4.47E−05 0.6074 0.6074 0.9954 0 rs1512989 Imputed T ADDITIVE 8.41E−05 8.41E−05 0.7101 0.7101 0.6962 0 rs1512989 Imputed T DOMINANT 4.47E−05 4.47E−05 0.6074 0.6074 0.9954 0 rs1512991 Imputed T ADDITIVE 0.000399 0.000399 0.7396 0.7396 0.8085 0 rs1512991 Imputed T DOMINANT 0.0001092 0.0001092 0.6115 0.6115 0.9069 0 rs1512991 Imputed T GENOTYPIC 0.001397 0.001397 0.5777 0.5777 0.6436 0 rs1524303 Imputed T GENOTYPIC 8.11E−05 8.11E−05 2.0455 2.0455 0.9122 0 rs1524306 Imputed C ADDITIVE 8.11E−05 8.11E−05 1.3995 1.3995 0.7142 0 rs1524306 Imputed C GENOTYPIC 4.94E−05 4.94E−05 2.1056 2.1056 0.9589 0 rs1524310 Imputed G ADDITIVE 7.36E−05 7.36E−05 1.404 1.404 0.6761 0 rs1524310 Imputed G GENOTYPIC 4.72E−05 4.72E−05 2.1176 2.1176 0.9271 0 rs1524321 Imputed C GENOTYPIC 6.09E−05 6.09E−05 2.0756 2.0756 0.7818 0 rs1527059 Imputed A DOMINANT 0.004607 0.004607 0.6321 0.6321 0.3968 0 rs152707 Imputed A ADDITIVE 6.74E−05 6.74E−05 0.7127 0.7127 0.5137 0 rs152707 Imputed A GENOTYPIC 9.17E−05 9.17E−05 0.4993 0.4993 0.3954 0 rs152712 Genotyped C ADDITIVE 4.47E−05 4.47E−05 0.7064 0.7064 0.5198 0 rs152712 Genotyped C GENOTYPIC 5.75E−05 5.75E−05 0.4894 0.4894 0.3791 0 rs1533994 Imputed T GENOTYPIC 6.29E−05 6.29E−05 2.0565 2.0565 0.9308 0 rs1535866 Imputed G DOMINANT 0.0004273 0.001126 1.5272 1.5369 0.2795 14.48 rs1563773 Imputed T GENOTYPIC 8.07E−05 8.07E−05 2.0358 2.0358 0.9519 0 rs1563774 Imputed T GENOTYPIC 8.07E−05 8.07E−05 2.0374 2.0374 0.8993 0 rs1567740 Imputed T ADDITIVE 8.27E−05 8.27E−05 0.7104 0.7104 0.7004 0 rs1567740 Imputed T DOMINANT 3.96E−05 3.96E−05 0.6056 0.6056 0.9636 0 rs1572573 Imputed A DOMINANT 6.70E−05 6.70E−05 1.64 1.64 0.4852 0 rs1577497 Imputed C RECESSIVE 7.41E−05 7.41E−05 0.5263 0.5263 0.5573 0 rs1581514 Imputed T ADDITIVE 8.95E−05 8.95E−05 1.3993 1.3993 0.6083 0 rs1581514 Imputed T GENOTYPIC 5.07E−05 5.07E−05 2.1081 2.1081 0.8699 0 rs1582321 Imputed T DOMINANT 4.17E−05 4.17E−05 0.6096 0.6096 0.5879 0 rs1582322 Imputed A DOMINANT 6.86E−05 6.86E−05 0.6175 0.6175 0.5471 0 rs1582323 Imputed A DOMINANT 6.70E−05 6.70E−05 0.6171 0.6171 0.5101 0 rs1592485 Imputed C DOMINANT 6.80E−05 6.80E−05 0.6167 0.6167 0.53 0 rs1600954 Imputed T ADDITIVE 6.34E−05 6.34E−05 1.4064 1.4064 0.7548 0 rs1600954 Imputed T GENOTYPIC 5.95E−05 5.95E−05 1.9926 1.9926 0.7001 0 rs16938626 Imputed G DOMINANT 6.17E−05 6.17E−05 0.6242 0.6242 0.8167 0 rs16964300 Imputed G ADDITIVE 0.0001511 0.0001511 0.6665 0.6665 0.8478 0 rs16964300 Imputed G DOMINANT 0.0001894 0.003074 0.6299 0.618 0.2025 38.44 rs16986282 Imputed G DOMINANT 0.001578 0.02315 0.4237 0.4355 0.1825 43.73 rs17007620 Imputed G ADDITIVE 6.23E−05 6.23E−05 1.5131 1.5131 0.4281 0 rs17007620 Imputed G DOMINANT 3.79E−05 3.79E−05 1.684 1.684 0.4732 0 rs17014326 Imputed G DOMINANT 3.13E−05 3.13E−05 0.6151 0.6151 0.5429 0 rs17047957 Imputed C DOMINANT 0.001421 0.001421 1.5018 1.5018 0.8023 0 rs1705261 Imputed A RECESSIVE 0.0006289 0.0006289 1.7058 1.7058 0.7466 0 rs17073341 Imputed A ADDITIVE 0.000719 0.03367 2.0963 1.9757 0.1667 47.71 rs17073341 Imputed A DOMINANT 0.0008057 0.0341 2.0915 1.9741 0.1677 47.47 rs17138702 Imputed G ADDITIVE 6.91E−05 6.91E−05 0.6037 0.6037 0.343 0 rs17189710 Imputed T ADDITIVE 0.00017 0.00017 1.3762 1.3762 0.8443 0 rs17189710 Imputed T GENOTYPIC 0.000209 0.000209 1.959 1.959 0.738 0 rs17189710 Imputed T RECESSIVE 0.001525 0.001525 1.7043 1.7043 0.4016 0 rs17310176 Imputed T ADDITIVE 0.0009735 0.001436 0.6909 0.6922 0.3063 4.46 rs17310176 Imputed T DOMINANT 0.0008163 0.01496 0.6548 0.6669 0.1994 39.27 rs17358860 Imputed A DOMINANT 0.002078 0.002078 0.6804 0.6804 0.407 0 rs17370541 Imputed T GENOTYPIC 9.33E−05 9.33E−05 2.055 2.055 0.3333 0 rs17370541 Imputed T RECESSIVE 6.92E−05 6.92E−05 1.969 1.969 0.671 0 rs17526574 Imputed G GENOTYPIC 7.89E−05 7.89E−05 2.2297 2.2297 0.9421 0 rs17530747 Imputed T DOMINANT 8.45E−05 8.45E−05 0.6272 0.6272 0.3668 0 rs17649114 Imputed C DOMINANT 0.002429 0.002429 1.4394 1.4394 0.4375 0 rs17766172 Imputed A RECESSIVE 0.0002007 0.0005167 0.4665 0.4683 0.2878 11.48 rs1818885 Imputed G GENOTYPIC 5.46E−05 5.46E−05 2.1046 2.1046 0.983 0 rs1832222 Imputed G DOMINANT 0.0001515 0.0001515 1.5562 1.5562 0.6814 0 rs1861327 Imputed G DOMINANT 4.17E−05 4.17E−05 0.6096 0.6096 0.5879 0 rs1868581 Imputed G ADDITIVE 7.20E−05 7.20E−05 1.4042 1.4042 0.6755 0 rs1868581 Imputed G GENOTYPIC 4.84E−05 4.84E−05 2.1147 2.1147 0.9348 0 rs1874313 Imputed A ADDITIVE 0.0001307 0.0001307 0.7177 0.7177 0.586 0 rs1874313 Imputed A DOMINANT 5.03E−05 5.03E−05 0.6096 0.6096 0.9203 0 rs1876409 Imputed C DOMINANT 6.56E−05 6.56E−05 0.6278 0.6278 0.8104 0 rs1913201 Imputed G ADDITIVE 0.0004633 0.0004633 0.7392 0.7392 0.7118 0 rs1913201 Imputed G DOMINANT 0.0002642 0.0002642 0.6285 0.6285 0.7714 0 rs1913201 Imputed G GENOTYPIC 0.001515 0.001515 0.574 0.574 0.5208 0 rs1916922 Imputed T GENOTYPIC 8.22E−05 8.22E−05 2.1096 2.1096 0.9454 0 rs1936871 Genotyped G DOMINANT 9.04E−05 9.04E−05 0.6214 0.6214 0.3679 0 rs1961157 Imputed T RECESSIVE 8.54E−05 8.54E−05 0.5553 0.5553 0.4429 0 rs1987179 Imputed T ADDITIVE 0.001935 0.001935 0.7236 0.7236 0.8673 0 rs1987179 Imputed T DOMINANT 0.000396 0.000396 0.6536 0.6536 0.8664 0 rs1990023 Imputed T DOMINANT 0.0005303 0.0005303 0.6661 0.6661 0.7286 0 rs1995025 Imputed C DOMINANT 0.001961 0.001961 1.5088 1.5088 0.5064 0 rs2016194 Imputed G DOMINANT 0.0007182 0.0007182 0.6718 0.6718 0.875 0 rs2023651 Imputed T ADDITIVE 3.73E−05 3.73E−05 0.6532 0.6532 0.5375 0 rs2024902 Imputed A ADDITIVE 7.20E−05 7.20E−05 1.9871 1.9871 0.9631 0 rs2024902 Imputed A DOMINANT 4.88E−05 4.88E−05 2.0957 2.0957 0.9413 0 rs2025107 Imputed A DOMINANT 5.94E−05 5.94E−05 1.9576 1.9576 0.6125 0 rs2025108 Imputed T DOMINANT 8.65E−05 8.65E−05 1.9168 1.9168 0.7647 0 rs2031987 Imputed T GENOTYPIC 7.93E−05 7.93E−05 2.2431 2.2431 0.9603 0 rs2052428 Imputed C DOMINANT 0.0001903 0.0001903 0.6109 0.6109 0.7253 0 rs2053230 Imputed C ADDITIVE 6.65E−05 6.65E−05 0.5491 0.5491 0.7036 0 rs2062448 Imputed T DOMINANT 9.26E−05 9.26E−05 0.5424 0.5424 0.9524 0 rs2063420 Imputed C RECESSIVE 8.43E−05 8.43E−05 1.8009 1.8009 0.8175 0 rs2063591 Imputed C ADDITIVE 0.001336 0.001336 0.7622 0.7622 0.8243 0 rs2063591 Imputed C DOMINANT 0.0001828 0.0001828 0.619 0.619 0.9374 0 rs208026 Genotyped A DOMINANT 0.0009159 0.0009159 1.4777 1.4777 0.8719 0 rs208029 Imputed T DOMINANT 0.0032 0.0032 1.4242 1.4242 0.911 0 rs208757 Imputed G DOMINANT 0.002063 0.002063 1.4401 1.4401 0.8897 0 rs2095586 Imputed A DOMINANT 9.55E−05 9.55E−05 1.582 1.582 0.6057 0 rs2095606 Imputed A DOMINANT 6.15E−06 6.15E−06 0.5812 0.5812 0.4893 0 rs2102374 Imputed A ADDITIVE 2.38E−05 2.38E−05 0.6664 0.6664 0.4161 0 rs2102374 Imputed A DOMINANT 1.59E−05 1.59E−05 0.6016 0.6016 0.9592 0 rs2108426 Imputed C DOMINANT 0.0007182 0.0007182 0.6718 0.6718 0.875 0 rs2110664 Imputed A DOMINANT 0.0002336 0.0002336 1.5536 1.5536 0.3488 0 rs2132242 Imputed A ADDITIVE 0.0001077 0.0001077 0.7156 0.7156 0.7142 0 rs2132242 Imputed A DOMINANT 5.48E−05 5.48E−05 0.6098 0.6098 0.9205 0 rs2158958 Imputed A DOMINANT 0.000699 0.000699 0.6712 0.6712 0.8706 0 rs2158961 Imputed G DOMINANT 0.000697 0.000697 0.6715 0.6715 0.7678 0 rs2163046 Imputed A DOMINANT 0.0008376 0.0008376 1.4873 1.4873 0.9201 0 rs2180286 Imputed G DOMINANT 0.001385 0.001385 0.6528 0.6528 0.6017 0 rs2180684 Imputed A DOMINANT 0.0009602 0.0009602 1.6598 1.6598 0.8934 0 rs2188079 Imputed C ADDITIVE 7.00E−05 7.00E−05 1.3978 1.3978 0.4286 0 rs2188079 Imputed C GENOTYPIC 4.81E−05 4.81E−05 2.0195 2.0195 0.6225 0 rs2190598 Imputed T DOMINANT 0.000699 0.000699 0.6712 0.6712 0.8706 0 rs2190600 Imputed A DOMINANT 0.0009994 0.0009994 0.6775 0.6775 0.9204 0 rs2224184 Genotyped T DOMINANT 0.001793 0.001793 0.6621 0.6621 0.6649 0 rs2247066 Imputed A DOMINANT 7.51E−05 7.51E−05 0.6306 0.6306 0.7714 0 rs2248236 Imputed C ADDITIVE 0.0005358 0.0005358 0.6815 0.6815 0.4894 0 rs2248236 Imputed C DOMINANT 0.0001555 0.0001555 0.619 0.619 0.8208 0 rs2265733 Imputed C ADDITIVE 2.38E−05 2.38E−05 0.6664 0.6664 0.4161 0 rs2265733 Imputed C DOMINANT 1.59E−05 1.59E−05 0.6016 0.6016 0.9592 0 rs2270584 Imputed A ADDITIVE 0.0001667 0.0001667 0.7239 0.7239 0.6562 0 rs2270584 Imputed A DOMINANT 1.41E−05 1.41E−05 0.5915 0.5915 0.9146 0 rs2270586 Imputed A ADDITIVE 0.0001716 0.0001716 0.7243 0.7243 0.6525 0 rs2270586 Imputed A DOMINANT 1.54E−05 1.54E−05 0.5928 0.5928 0.9252 0 rs229775 Imputed A RECESSIVE 0.000111 0.000111 0.4573 0.4573 0.3307 0 rs229815 Imputed T RECESSIVE 0.0002282 0.0002282 0.4565 0.4565 0.4856 0 rs229829 Imputed C RECESSIVE 0.0005435 0.0005435 0.5446 0.5446 0.5763 0 rs229831 Imputed A RECESSIVE 0.0002275 0.002067 0.469 0.4773 0.2519 23.81 rs2317057 Imputed T ADDITIVE 0.002089 0.002089 0.7151 0.7151 0.9648 0 rs2322100 Genotyped T RECESSIVE 0.000848 0.000848 2.0921 2.0921 0.3268 0 rs2322101 Imputed A RECESSIVE 0.0008488 0.0008488 2.0923 2.0923 0.3199 0 rs2327929 Imputed G RECESSIVE 6.56E−05 6.56E−05 1.7968 1.7968 0.3419 0 rs2332844 Imputed A ADDITIVE 2.83E−05 2.83E−05 1.7997 1.7997 0.9786 0 rs2332844 Imputed A RECESSIVE 0.0001148 0.0001148 1.8396 1.8396 0.9347 0 rs2349170 Imputed G DOMINANT 0.0004675 0.0004675 1.5226 1.5226 0.4042 0 rs2356722 Imputed G DOMINANT 2.78E−05 2.78E−05 0.6136 0.6136 0.5952 0 rs2364956 Imputed T ADDITIVE 7.88E−05 7.88E−05 1.5326 1.5326 0.464 0 rs2373793 Imputed G ADDITIVE 0.0006153 0.0006153 1.4555 1.4555 0.5436 0 rs2373793 Imputed G DOMINANT 0.0002422 0.0002422 1.5984 1.5984 0.3199 0 rs238252 Imputed G ADDITIVE 3.92E−05 3.92E−05 1.6115 1.6115 0.7369 0 rs238252 Imputed G DOMINANT 2.65E−05 2.65E−05 1.7462 1.7462 0.5867 0 rs2383903 Imputed G DOMINANT 9.89E−05 9.89E−05 0.6336 0.6336 0.873 0 rs2387945 Imputed G DOMINANT 0.002288 0.002288 1.4967 1.4967 0.5359 0 rs2389863 Imputed A DOMINANT 0.0005489 0.0005489 0.6585 0.6585 0.8176 0 rs2389866 Imputed C DOMINANT 0.000396 0.000396 0.6536 0.6536 0.8664 0 rs2389869 Imputed C DOMINANT 0.000396 0.000396 0.6536 0.6536 0.8664 0 rs2389870 Genotyped C DOMINANT 0.003433 0.003433 0.6945 0.6945 0.3965 0 rs2418494 Imputed G ADDITIVE 0.002097 0.002097 0.7772 0.7772 0.4019 0 rs2418494 Imputed G GENOTYPIC 0.001772 0.001772 0.5989 0.5989 0.3574 0 rs2418541 Imputed A DOMINANT 0.0005303 0.0005303 0.6661 0.6661 0.7286 0 rs2418542 Imputed A DOMINANT 0.0005772 0.0005772 0.6679 0.6679 0.7414 0 rs2423556 Imputed C DOMINANT 0.001354 0.001354 0.6507 0.6507 0.5885 0 rs2437688 Imputed C ADDITIVE 0.004791 0.004791 1.4661 1.4661 0.9462 0 rs2456809 Imputed G DOMINANT 6.91E−05 6.91E−05 0.6286 0.6286 0.7989 0 rs2456811 Imputed T ADDITIVE 2.64E−05 2.64E−05 0.6679 0.6679 0.4268 0 rs2456811 Imputed T DOMINANT 1.79E−05 1.79E−05 0.6034 0.6034 0.9743 0 rs2476976 Imputed C DOMINANT 0.0002835 0.0002835 1.5277 1.5277 0.6105 0 rs2484911 Imputed A DOMINANT 0.0002659 0.0002659 1.5304 1.5304 0.8231 0 rs2488557 Imputed C DOMINANT 9.46E−05 9.46E−05 0.5776 0.5776 0.6502 0 rs250162 Imputed C ADDITIVE 0.000113 0.0003838 0.6768 0.6731 0.2772 15.32 rs250162 Imputed C DOMINANT 4.84E−05 0.0006095 0.6135 0.6056 0.2344 29.27 rs2560708 Imputed T ADDITIVE 0.0002656 0.0002656 0.6487 0.6487 0.5707 0 rs2617841 Imputed G DOMINANT 0.0002103 0.0002103 0.633 0.633 0.4225 0 rs2622499 Imputed G DOMINANT 0.0004741 0.0004741 0.6573 0.6573 0.8397 0 rs264129 Imputed T DOMINANT 0.0007594 0.0007594 0.6718 0.6718 0.7413 0 rs2642936 Imputed T ADDITIVE 9.35E−05 9.35E−05 1.4936 1.4936 0.3776 0 rs2660633 Imputed A DOMINANT 6.56E−05 6.56E−05 0.6278 0.6278 0.8104 0 rs2660634 Imputed C DOMINANT 6.56E−05 6.56E−05 0.6278 0.6278 0.8104 0 rs2660648 Imputed A ADDITIVE 2.38E−05 2.38E−05 0.6664 0.6664 0.4161 0 rs2660648 Imputed A DOMINANT 1.59E−05 1.59E−05 0.6016 0.6016 0.9592 0 rs2681505 Imputed T ADDITIVE 1.62E−05 1.62E−05 0.6474 0.6474 0.7786 0 rs277411 Imputed G DOMINANT 4.27E−05 4.27E−05 0.3261 0.3261 0.7363 0 rs2832634 Imputed G ADDITIVE 0.001422 0.001422 1.8637 1.8637 0.4977 0 rs2832637 Imputed T ADDITIVE 0.001422 0.001422 1.8637 1.8637 0.4977 0 rs2843167 Imputed A DOMINANT 4.64E−05 4.64E−05 0.6208 0.6208 0.6602 0 rs2876227 Imputed C ADDITIVE 0.0004318 0.0004318 1.3526 1.3526 0.8494 0 rs2876227 Imputed C GENOTYPIC 0.0004406 0.0004406 1.9073 1.9073 0.726 0 rs2882097 Imputed A DOMINANT 8.97E−05 8.97E−05 1.5819 1.5819 0.6066 0 rs2909862 Imputed G DOMINANT 8.19E−05 8.19E−05 1.7275 1.7275 0.4161 0 rs3001945 Imputed T DOMINANT 0.001929 0.001929 1.5254 1.5254 0.656 0 rs3011020 Imputed C DOMINANT 0.002194 0.002194 1.4992 1.4992 0.5299 0 rs36071725 Genotyped C ADDITIVE 4.45E−06 4.45E−06 1.4999 1.4999 0.8099 0 rs36071725 Genotyped C GENOTYPIC 2.95E−06 1.95E−05 2.5235 2.5053 0.2811 13.92 rs373983 Imputed G DOMINANT 0.001847 0.001847 1.4715 1.4715 0.5548 0 rs3743794 Imputed G DOMINANT 9.02E−05 9.02E−05 0.6224 0.6224 0.5016 0 rs3756154 Imputed C ADDITIVE 0.001935 0.001935 0.7236 0.7236 0.8673 0 rs3756154 Imputed C DOMINANT 0.000396 0.000396 0.6536 0.6536 0.8664 0 rs3775850 Imputed A DOMINANT 0.001884 0.001884 0.6779 0.6779 0.3941 0 rs3775851 Imputed C DOMINANT 0.00239 0.00239 0.6839 0.6839 0.4246 0 rs3793044 Imputed C ADDITIVE 9.83E−05 9.83E−05 1.9638 1.9638 0.8837 0 rs3793044 Imputed C DOMINANT 6.76E−05 6.76E−05 2.0697 2.0697 0.9811 0 rs3793053 Imputed C DOMINANT 5.01E−05 5.01E−05 1.9787 1.9787 0.624 0 rs3796246 Imputed G DOMINANT 8.90E−05 8.90E−05 0.5398 0.5398 0.4358 0 rs3806003 Imputed A ADDITIVE 9.83E−05 9.83E−05 1.9638 1.9638 0.8837 0 rs3806003 Imputed A DOMINANT 6.76E−05 6.76E−05 2.0697 2.0697 0.9811 0 rs3806004 Imputed T DOMINANT 5.94E−05 5.94E−05 1.9576 1.9576 0.6125 0 rs3806010 Imputed T DOMINANT 5.94E−05 5.94E−05 1.9576 1.9576 0.6125 0 rs3806014 Imputed T DOMINANT 5.67E−05 5.67E−05 1.9649 1.9649 0.6221 0 rs3806015 Imputed A DOMINANT 5.94E−05 5.94E−05 1.9576 1.9576 0.6125 0 rs3806018 Imputed A DOMINANT 7.82E−05 7.82E−05 1.9419 1.9419 0.5908 0 rs3806019 Imputed A DOMINANT 5.94E−05 5.94E−05 1.9576 1.9576 0.6125 0 rs3806024 Imputed T DOMINANT 5.01E−05 5.01E−05 1.9787 1.9787 0.624 0 rs3915080 Imputed A GENOTYPIC 5.44E−05 5.44E−05 2.0907 2.0907 0.9248 0 rs3942254 Imputed T ADDITIVE 0.0001416 0.0001416 0.7166 0.7166 0.775 0 rs3942254 Imputed T DOMINANT 7.52E−05 7.52E−05 0.6139 0.6139 0.912 0 rs3945085 Imputed A DOMINANT 6.75E−05 6.75E−05 1.5947 1.5947 0.7622 0 rs3976737 Imputed G ADDITIVE 4.73E−05 4.73E−05 0.6147 0.6147 0.6857 0 rs399485 Imputed A DOMINANT 0.001322 0.001322 1.4553 1.4553 0.9598 0 rs4029119 Imputed G ADDITIVE 2.65E−05 2.65E−05 0.2569 0.2569 0.4764 0 rs4029119 Imputed G DOMINANT 5.81E−05 5.81E−05 0.2637 0.2637 0.5057 0 rs4076201 Imputed G GENOTYPIC 0.0001779 0.0001779 3.0129 3.0129 0.881 0 rs4076201 Imputed G RECESSIVE 0.0001745 0.0001745 2.9721 2.9721 0.9936 0 rs41395945 Imputed G ADDITIVE 0.001422 0.001422 1.8637 1.8637 0.4977 0 rs41395945 Imputed G DOMINANT 0.001383 0.001383 1.9054 1.9054 0.5854 0 rs4146972 Genotyped T DOMINANT 0.002023 0.002023 1.4758 1.4758 0.7768 0 rs4238087 Imputed G DOMINANT 0.001528 0.002511 0.6487 0.6459 0.2941 9.14 rs4251569 Imputed T ADDITIVE 0.000865 0.000865 0.6585 0.6585 0.319 0 rs4251569 Imputed T DOMINANT 0.001524 0.002494 0.6487 0.6458 0.2944 9.05 rs4273613 Imputed T ADDITIVE 1.27E−05 1.27E−05 0.2451 0.2451 0.6218 0 rs4273613 Imputed T DOMINANT 2.81E−05 2.81E−05 0.2509 0.2509 0.6535 0 rs4291049 Imputed T RECESSIVE 6.91E−05 6.91E−05 0.5605 0.5605 0.8377 0 rs4315598 Imputed T ADDITIVE 0.0002132 0.0002132 1.369 1.369 0.8084 0 rs4315598 Imputed T GENOTYPIC 0.0002436 0.0002436 1.9445 1.9445 0.7616 0 rs4315598 Imputed T RECESSIVE 0.001637 0.001637 1.6981 1.6981 0.4109 0 rs4321395 Imputed A DOMINANT 4.10E−05 4.10E−05 0.5856 0.5856 0.5635 0 rs4321596 Genotyped T RECESSIVE 0.001013 0.001013 2.3233 2.3233 0.5608 0 rs4324417 Imputed T DOMINANT 9.41E−05 9.41E−05 1.6531 1.6531 0.6731 0 rs4328619 Genotyped G DOMINANT 0.002587 0.002587 0.6704 0.6704 0.826 0 rs4338909 Imputed T ADDITIVE 9.61E−05 9.61E−05 1.3842 1.3842 0.8254 0 rs4370878 Imputed G DOMINANT 9.82E−05 9.82E−05 1.5785 1.5785 0.7378 0 rs4379434 Genotyped T DOMINANT 9.48E−05 9.48E−05 1.6163 1.6163 0.9593 0 rs4416407 Imputed T DOMINANT 0.0001694 0.0001694 1.6929 1.6929 0.489 0 rs4417899 Imputed C RECESSIVE 0.000157 0.000157 0.5892 0.5892 0.4805 0 rs4442732 Imputed A ADDITIVE 8.41E−05 8.41E−05 0.6531 0.6531 0.3436 0 rs4444612 Imputed G ADDITIVE 0.0001677 0.0001677 1.3768 1.3768 0.8476 0 rs4444612 Imputed G GENOTYPIC 0.00021 0.00021 1.9589 1.9589 0.738 0 rs4444612 Imputed G RECESSIVE 0.001571 0.001571 1.7015 1.7015 0.4057 0 rs4450660 Imputed C DOMINANT 8.36E−05 8.36E−05 1.5918 1.5918 0.5023 0 rs4509702 Imputed C DOMINANT 9.82E−05 9.82E−05 1.5785 1.5785 0.7378 0 rs4526920 Imputed G GENOTYPIC 7.93E−05 7.93E−05 2.2431 2.2431 0.9603 0 rs4533145 Imputed T DOMINANT 9.22E−05 9.22E−05 0.5529 0.5529 0.3518 0 rs4557006 Imputed A DOMINANT 8.75E−05 8.75E−05 0.5972 0.5972 0.5878 0 rs4570530 Imputed C DOMINANT 9.82E−05 9.82E−05 1.5785 1.5785 0.7378 0 rs4615971 Imputed C DOMINANT 0.0001298 0.0001298 1.5635 1.5635 0.7109 0 rs4628119 Imputed A DOMINANT 6.11E−05 6.11E−05 0.6205 0.6205 0.3365 0 rs4664443 Imputed G ADDITIVE 7.56E−05 7.56E−05 0.7086 0.7086 0.8496 0 rs4688259 Imputed T DOMINANT 0.0001678 0.0001678 1.6935 1.6935 0.4878 0 rs4688632 Imputed G RECESSIVE 0.0001642 0.0001642 0.5987 0.5987 0.51 0 rs4695284 Imputed A ADDITIVE 8.64E−05 8.64E−05 1.894 1.894 0.3836 0 rs4700302 Imputed A ADDITIVE 9.09E−05 9.09E−05 0.5243 0.5243 0.8943 0 rs4702720 Imputed A ADDITIVE 0.0001094 0.0001094 0.6414 0.6414 0.5372 0 rs4702720 Imputed A DOMINANT 0.0001621 0.0001621 0.5989 0.5989 0.3199 0 rs4711091 Genotyped G GENOTYPIC 9.08E−05 9.08E−05 1.8967 1.8967 0.4866 0 rs4714484 Imputed A ADDITIVE 4.13E−05 4.13E−05 0.6276 0.6276 0.4538 0 rs4736802 Imputed G DOMINANT 7.12E−05 7.12E−05 1.6304 1.6304 0.9501 0 rs4760785 Imputed A ADDITIVE 0.0004633 0.0004633 0.7392 0.7392 0.7118 0 rs4760785 Imputed A DOMINANT 0.0002642 0.0002642 0.6285 0.6285 0.7714 0 rs4760785 Imputed A GENOTYPIC 0.001515 0.001515 0.574 0.574 0.5208 0 rs4760894 Imputed T ADDITIVE 0.0004633 0.0004633 0.7392 0.7392 0.7118 0 rs4760894 Imputed T DOMINANT 0.0002642 0.0002642 0.6285 0.6285 0.7714 0 rs4760894 Imputed T GENOTYPIC 0.001515 0.001515 0.574 0.574 0.5208 0 rs4760895 Imputed A ADDITIVE 0.0004633 0.0004633 0.7392 0.7392 0.7118 0 rs4760895 Imputed A DOMINANT 0.0002642 0.0002642 0.6285 0.6285 0.7714 0 rs4760895 Imputed A GENOTYPIC 0.001515 0.001515 0.574 0.574 0.5208 0 rs4764738 Imputed A ADDITIVE 5.30E−05 5.30E−05 1.4051 1.4051 0.3785 0 rs4764738 Imputed A GENOTYPIC 5.29E−05 5.29E−05 1.9728 1.9728 0.3836 0 rs4764974 Imputed T ADDITIVE 9.56E−05 9.56E−05 1.3855 1.3855 0.4436 0 rs4764974 Imputed T GENOTYPIC 9.35E−05 9.35E−05 1.9196 1.9196 0.4483 0 rs4798366 Imputed G RECESSIVE 0.001711 0.001711 1.8332 1.8332 0.3582 0 rs483159 Imputed T DOMINANT 0.004772 0.004772 1.4202 1.4202 0.9716 0 rs4836502 Imputed T DOMINANT 0.000699 0.000699 0.6712 0.6712 0.8706 0 rs4836507 Imputed C DOMINANT 0.0009994 0.0009994 0.6775 0.6775 0.9204 0 rs4836744 Imputed A ADDITIVE 0.0006425 0.0006425 0.7345 0.7345 0.7018 0 rs4836744 Imputed A DOMINANT 0.001186 0.001186 0.6854 0.6854 0.8412 0 rs4848944 Genotyped C RECESSIVE 0.0002524 0.003005 0.5945 0.5819 0.2143 35.17 rs4851529 Imputed A DOMINANT 0.0003125 0.0003125 0.6476 0.6476 0.4109 0 rs4851531 Imputed T DOMINANT 0.000688 0.0011 0.6621 0.6602 0.2981 7.64 rs4858046 Genotyped T GENOTYPIC 7.90E−05 7.90E−05 2.0533 2.0533 0.925 0 rs4878214 Imputed A ADDITIVE 9.56E−05 9.56E−05 0.6477 0.6477 0.3504 0 rs4880803 Imputed A ADDITIVE 0.003664 0.003664 0.7694 0.7694 0.9093 0 rs489441 Imputed G ADDITIVE 3.10E−05 3.10E−05 1.4992 1.4992 0.6179 0 rs489441 Imputed G DOMINANT 8.27E−05 8.27E−05 1.6072 1.6072 0.8697 0 rs4896568 Imputed T DOMINANT 8.36E−05 8.36E−05 0.6231 0.6231 0.3985 0 rs4938851 Imputed T DOMINANT 0.001901 0.001901 1.4515 1.4515 0.4953 0 rs4964416 Imputed C DOMINANT 0.0004167 0.0004167 0.6251 0.6251 0.6468 0 rs5756669 Imputed C DOMINANT 9.41E−05 9.41E−05 1.6531 1.6531 0.6731 0 rs6033138 Imputed C ADDITIVE 0.000116 0.000116 1.3837 1.3837 0.8829 0 rs6033138 Imputed C GENOTYPIC 0.0001829 0.0001829 1.9484 1.9484 0.7574 0 rs6033138 Imputed C RECESSIVE 0.001659 0.001659 1.6769 1.6769 0.4494 0 rs6040619 Imputed C ADDITIVE 0.0001132 0.0001132 1.3881 1.3881 0.5479 0 rs6040619 Imputed C GENOTYPIC 9.53E−05 9.53E−05 2.0334 2.0334 0.8541 0 rs6040619 Imputed C RECESSIVE 0.0005843 0.0005843 1.7879 1.7879 0.803 0 rs6040625 Imputed T ADDITIVE 0.0001123 0.0001123 1.3888 1.3888 0.589 0 rs6040625 Imputed T GENOTYPIC 0.0001128 0.0001128 2.0214 2.0214 0.9212 0 rs6040625 Imputed T RECESSIVE 0.0007645 0.0007645 1.7684 1.7684 0.7342 0 rs6040630 Imputed A ADDITIVE 0.0001671 0.0001671 1.3767 1.3767 0.7848 0 rs6040630 Imputed A GENOTYPIC 0.0001796 0.0001796 1.9741 1.9741 0.807 0 rs6040630 Imputed A RECESSIVE 0.001227 0.001227 1.7241 1.7241 0.4626 0 rs6040633 Imputed A ADDITIVE 0.000204 0.000204 1.3703 1.3703 0.8149 0 rs6040633 Imputed A GENOTYPIC 0.0002355 0.0002355 1.9475 1.9475 0.7566 0 rs6040633 Imputed A RECESSIVE 0.001596 0.001596 1.6999 1.6999 0.4082 0 rs6040634 Imputed T ADDITIVE 0.0001909 0.0001909 1.3722 1.3722 0.8246 0 rs6040634 Imputed T GENOTYPIC 0.0002206 0.0002206 1.9531 1.9531 0.7476 0 rs6040634 Imputed T RECESSIVE 0.00156 0.00156 1.7021 1.7021 0.4049 0 rs6040636 Imputed T ADDITIVE 0.0001672 0.0001672 1.3761 1.3761 0.8442 0 rs6040636 Imputed T GENOTYPIC 0.0002085 0.0002085 1.9585 1.9585 0.7388 0 rs6040636 Imputed T RECESSIVE 0.00156 0.00156 1.7021 1.7021 0.4049 0 rs6040638 Imputed C ADDITIVE 0.0001909 0.0001909 1.3722 1.3722 0.8246 0 rs6040638 Imputed C GENOTYPIC 0.0002206 0.0002206 1.9531 1.9531 0.7476 0 rs6040638 Imputed C RECESSIVE 0.00156 0.00156 1.7021 1.7021 0.4049 0 rs6040644 Imputed A ADDITIVE 0.0001909 0.0001909 1.3722 1.3722 0.8246 0 rs6040644 Imputed A GENOTYPIC 0.0002206 0.0002206 1.9531 1.9531 0.7476 0 rs6040644 Imputed A RECESSIVE 0.00156 0.00156 1.7021 1.7021 0.4049 0 rs6040667 Imputed T ADDITIVE 0.0002664 0.0002664 1.3662 1.3662 0.8727 0 rs6040667 Imputed T GENOTYPIC 0.0003065 0.0003065 1.9386 1.9386 0.7287 0 rs6040667 Imputed T RECESSIVE 0.002069 0.002069 1.6903 1.6903 0.423 0 rs6040668 Imputed C ADDITIVE 0.0002909 0.0002909 1.3643 1.3643 0.8891 0 rs6040668 Imputed C GENOTYPIC 0.0003326 0.0003326 1.9325 1.9325 0.7115 0 rs6040668 Imputed C RECESSIVE 0.00224 0.00224 1.6839 1.6839 0.406 0 rs6043066 Genotyped G DOMINANT 0.000733 0.01784 1.4888 1.4596 0.1886 42.14 rs6048146 Imputed G DOMINANT 0.0005426 0.0005426 2.6562 2.6562 0.6095 0 rs6082725 Genotyped T DOMINANT 0.0005426 0.0005426 2.6562 2.6562 0.6095 0 rs6131206 Imputed C ADDITIVE 0.002048 0.002048 1.3126 1.3126 0.4818 0 rs6131208 Imputed T ADDITIVE 0.0002137 0.0002137 1.3725 1.3725 0.8701 0 rs6131208 Imputed T GENOTYPIC 0.0002553 0.0002553 1.9551 1.9551 0.7372 0 rs6131208 Imputed T RECESSIVE 0.00182 0.00182 1.7011 1.7011 0.4342 0 rs6134243 Imputed C ADDITIVE 0.0001909 0.0001909 1.3722 1.3722 0.8246 0 rs6134243 Imputed C GENOTYPIC 0.0002206 0.0002206 1.9531 1.9531 0.7476 0 rs6134243 Imputed C RECESSIVE 0.00156 0.00156 1.7021 1.7021 0.4049 0 rs6136020 Imputed A DOMINANT 6.99E−05 7.15E−05 0.5953 0.5953 0.3168 0.19 rs613799 Imputed C DOMINANT 0.0002827 0.0002827 1.5657 1.5657 0.629 0 rs644041 Imputed G ADDITIVE 9.69E−05 9.69E−05 1.4631 1.4631 0.6439 0 rs644041 Imputed G DOMINANT 0.0001835 0.0001835 1.5751 1.5751 0.8914 0 rs647645 Imputed C ADDITIVE 2.08E−05 2.08E−05 0.7025 0.7025 0.8072 0 rs647645 Imputed C GENOTYPIC 1.62E−05 1.62E−05 0.4822 0.4822 0.9069 0 rs647645 Imputed C RECESSIVE 4.05E−05 4.05E−05 0.5474 0.5474 0.5771 0 rs6495554 Imputed C GENOTYPIC 0.0001138 0.0001138 3.4509 3.4509 0.8527 0 rs6495554 Imputed C RECESSIVE 0.0001586 0.0001586 3.317 3.317 0.9056 0 rs6495555 Imputed C GENOTYPIC 0.0001138 0.0001138 3.4509 3.4509 0.8527 0 rs6495555 Imputed C RECESSIVE 0.0001586 0.0001586 3.317 3.317 0.9056 0 rs6544728 Imputed T DOMINANT 2.92E−05 2.92E−05 1.6406 1.6406 0.3945 0 rs6550705 Imputed C ADDITIVE 8.91E−05 8.91E−05 1.3969 1.3969 0.7348 0 rs6550705 Imputed C GENOTYPIC 5.30E−05 5.30E−05 2.0995 2.0995 0.9749 0 rs6550707 Imputed T GENOTYPIC 7.67E−05 7.67E−05 2.0358 2.0358 0.8969 0 rs658108 Imputed A DOMINANT 0.0002659 0.0002659 1.5304 1.5304 0.8231 0 rs6593441 Imputed A DOMINANT 0.0002048 0.0002048 1.6724 1.6724 0.545 0 rs668732 Imputed A DOMINANT 7.59E−05 7.59E−05 1.6958 1.6958 0.6376 0 rs671041 Imputed A DOMINANT 0.0002098 0.0002098 1.5412 1.5412 0.8876 0 rs6719700 Imputed A ADDITIVE 0.0005301 0.0005301 1.4892 1.4892 0.6569 0 rs6719700 Imputed A DOMINANT 0.0009974 0.0009974 1.5282 1.5282 0.9621 0 rs6722640 Imputed T DOMINANT 0.0001647 0.0001647 0.6343 0.6343 0.417 0 rs6743092 Imputed T ADDITIVE 0.0002329 0.0002329 1.3618 1.3618 0.9832 0 rs6743092 Imputed T GENOTYPIC 0.0002232 0.0002232 1.8571 1.8571 0.9791 0 rs6743092 Imputed T RECESSIVE 0.001144 0.001144 1.5648 1.5648 0.9735 0 rs6744759 Imputed G RECESSIVE 0.006086 0.006086 1.7637 1.7637 0.7956 0 rs6746170 Imputed A DOMINANT 4.95E−05 4.95E−05 1.6166 1.6166 0.5054 0 rs6759922 Imputed A DOMINANT 5.10E−05 5.10E−05 0.5892 0.5892 0.6074 0 rs6769864 Imputed T GENOTYPIC 5.78E−05 5.78E−05 2.0921 2.0921 0.9627 0 rs6773932 Imputed C GENOTYPIC 8.12E−05 8.12E−05 2.0503 2.0503 0.8139 0 rs6774353 Imputed A GENOTYPIC 5.78E−05 5.78E−05 2.0921 2.0921 0.9627 0 rs6781670 Imputed C GENOTYPIC 7.91E−05 7.91E−05 2.0683 2.0683 0.8608 0 rs6786431 Imputed A GENOTYPIC 8.12E−05 8.12E−05 2.0503 2.0503 0.8139 0 rs6789091 Imputed T GENOTYPIC 8.12E−05 8.12E−05 2.0503 2.0503 0.8139 0 rs6791296 Imputed T ADDITIVE 0.0005376 0.0005376 0.6284 0.6284 0.9209 0 rs6792662 Imputed G DOMINANT 0.0001499 0.0001499 1.7002 1.7002 0.4736 0 rs6797574 Imputed G GENOTYPIC 8.12E−05 8.12E−05 2.0503 2.0503 0.8139 0 rs6797882 Imputed G GENOTYPIC 7.58E−05 7.58E−05 2.0585 2.0585 0.8005 0 rs6805139 Imputed G DOMINANT 0.0001083 0.0001083 1.6957 1.6957 0.5312 0 rs6806043 Imputed C ADDITIVE 6.97E−05 6.97E−05 1.4041 1.4041 0.6772 0 rs6806043 Imputed C GENOTYPIC 4.41E−05 4.41E−05 2.1162 2.1162 0.9314 0 rs6850716 Imputed C GENOTYPIC 6.01E−05 6.01E−05 3.2642 3.2642 0.9641 0 rs6867153 Imputed A RECESSIVE 3.66E−05 3.66E−05 0.5455 0.5455 0.7414 0 rs687047 Imputed C ADDITIVE 0.001907 0.001907 0.6716 0.6716 0.7468 0 rs6871041 Imputed G DOMINANT 0.0002601 0.0002601 0.6351 0.6351 0.5713 0 rs688358 Imputed A ADDITIVE 0.001332 0.001332 0.6614 0.6614 0.8904 0 rs6888012 Imputed A RECESSIVE 3.66E−05 3.66E−05 0.5455 0.5455 0.7414 0 rs6908481 Imputed C RECESSIVE 8.53E−05 8.53E−05 1.8461 1.8461 0.6072 0 rs7032231 Imputed A ADDITIVE 0.003089 0.004335 1.2986 1.3011 0.2989 7.33 rs7067638 Imputed T DOMINANT 0.0002484 0.0002484 1.6722 1.6722 0.663 0 rs7077799 Imputed A DOMINANT 0.0002066 0.0002066 1.5609 1.5609 0.6624 0 rs7082163 Imputed A ADDITIVE 4.21E−05 4.21E−05 1.6619 1.6619 0.5882 0 rs7082163 Imputed A DOMINANT 6.78E−05 6.78E−05 1.7473 1.7473 0.7157 0 rs7089661 Imputed C DOMINANT 0.0001345 0.0001345 1.5612 1.5612 0.6665 0 rs7101319 Imputed C ADDITIVE 5.11E−05 5.11E−05 1.6533 1.6533 0.5666 0 rs7101319 Imputed C DOMINANT 8.45E−05 8.45E−05 1.7359 1.7359 0.6904 0 rs710832 Genotyped A GENOTYPIC 0.0003218 0.0003218 0.3641 0.3641 0.5473 0 rs710832 Genotyped A RECESSIVE 0.0001214 0.0001214 0.3456 0.3456 0.5387 0 rs7134262 Imputed T GENOTYPIC 0.0005116 0.0005116 1.9228 1.9228 0.357 0 rs7134262 Imputed T RECESSIVE 1.88E−05 0.0002297 2.1112 2.0864 0.2602 21.12 rs7134671 Imputed T GENOTYPIC 8.82E−05 8.82E−05 1.9952 1.9952 0.3861 0 rs7138300 Imputed C ADDITIVE 0.0004633 0.0004633 0.7392 0.7392 0.7118 0 rs7138300 Imputed C DOMINANT 0.0002642 0.0002642 0.6285 0.6285 0.7714 0 rs7138300 Imputed C GENOTYPIC 0.001515 0.001515 0.574 0.574 0.5208 0 rs7163931 Imputed G GENOTYPIC 0.0001138 0.0001138 3.4509 3.4509 0.8527 0 rs7163931 Imputed G RECESSIVE 0.0001586 0.0001586 3.317 3.317 0.9056 0 rs7171486 Genotyped G DOMINANT 0.002255 0.00726 0.6976 0.69 0.2524 23.66 rs7172611 Imputed G GENOTYPIC 0.0001106 0.0001106 3.4591 3.4591 0.8474 0 rs7172611 Imputed G RECESSIVE 0.0001586 0.0001586 3.317 3.317 0.9056 0 rs7172689 Imputed T GENOTYPIC 0.0001106 0.0001106 3.4591 3.4591 0.8474 0 rs7172689 Imputed T RECESSIVE 0.0001586 0.0001586 3.317 3.317 0.9056 0 rs7175701 Imputed C GENOTYPIC 0.0002485 0.0002485 2.9103 2.9103 0.9903 0 rs7180245 Imputed A GENOTYPIC 0.0001106 0.0001106 3.4591 3.4591 0.8474 0 rs7180245 Imputed A RECESSIVE 0.0001586 0.0001586 3.317 3.317 0.9056 0 rs7220603 Genotyped A ADDITIVE 6.15E−05 6.15E−05 0.6874 0.6874 0.5095 0 rs7282518 Imputed T ADDITIVE 4.72E−05 4.72E−05 1.6157 1.6157 0.6576 0 rs7283476 Imputed T ADDITIVE 0.001444 0.002668 0.4528 0.4555 0.2951 8.76 rs7283476 Imputed T DOMINANT 0.001188 0.01352 0.4307 0.4432 0.213 35.52 rs7295817 Imputed C GENOTYPIC 0.001617 0.007423 0.5763 0.5838 0.2587 21.63 rs7298255 Imputed A ADDITIVE 0.0004959 0.0004959 0.7441 0.7441 0.8645 0 rs7298255 Imputed A DOMINANT 0.0001567 0.0001567 0.6197 0.6197 0.8009 0 rs7305832 Imputed C GENOTYPIC 0.0004601 0.0004601 1.9292 1.9292 0.3332 0 rs7305832 Imputed C RECESSIVE 1.85E−05 0.0003707 2.1109 2.0804 0.2465 25.55 rs7331467 Imputed A GENOTYPIC 8.27E−05 8.27E−05 2.0747 2.0747 0.9516 0 rs7392620 Imputed C ADDITIVE 0.003409 0.003409 0.7677 0.7677 0.844 0 rs742827 Imputed A ADDITIVE 0.0001374 0.0001374 1.3962 1.3962 0.8859 0 rs742827 Imputed A GENOTYPIC 0.0002152 0.0002152 1.9872 1.9872 0.5834 0 rs742827 Imputed A RECESSIVE 0.001964 0.001964 1.6988 1.6988 0.3688 0 rs7446891 Imputed G DOMINANT 0.000699 0.000699 0.6712 0.6712 0.8706 0 rs7448641 Imputed C ADDITIVE 1.27E−05 1.27E−05 0.2451 0.2451 0.6218 0 rs7448641 Imputed C DOMINANT 2.81E−05 2.81E−05 0.2509 0.2509 0.6535 0 rs7484728 Imputed T GENOTYPIC 8.08E−05 8.08E−05 2.0019 2.0019 0.395 0 rs7499402 Genotyped A ADDITIVE 0.001818 0.001818 1.6071 1.6071 0.4709 0 rs7529851 Imputed A ADDITIVE 0.0007167 0.0007351 0.7475 0.7475 0.3163 0.4 rs7529851 Imputed A GENOTYPIC 0.0007339 0.0007339 0.5463 0.5463 0.4438 0 rs7573951 Imputed G ADDITIVE 7.56E−05 7.56E−05 0.7086 0.7086 0.8496 0 rs7599198 Imputed T DOMINANT 9.29E−05 9.29E−05 0.5939 0.5939 0.6564 0 rs7600050 Imputed C ADDITIVE 0.000398 0.000398 1.3671 1.3671 0.401 0 rs7607712 Imputed T ADDITIVE 0.0003189 0.0003189 1.452 1.452 0.6392 0 rs7607712 Imputed T DOMINANT 0.0007082 0.0007082 1.5005 1.5005 0.8593 0 rs7613492 Imputed G GENOTYPIC 5.46E−05 5.46E−05 2.1046 2.1046 0.983 0 rs7621663 Imputed G ADDITIVE 5.19E−05 5.19E−05 1.4264 1.4264 0.8945 0 rs7621663 Imputed G GENOTYPIC 1.68E−05 1.68E−05 2.2926 2.2926 0.7204 0 rs7621663 Imputed G RECESSIVE 8.03E−05 8.03E−05 2.0424 2.0424 0.5218 0 rs7626584 Imputed G ADDITIVE 0.000166 0.000166 0.5017 0.5017 0.6498 0 rs7684899 Imputed C ADDITIVE 0.001935 0.001935 0.7236 0.7236 0.8673 0 rs7684899 Imputed C DOMINANT 0.000396 0.000396 0.6536 0.6536 0.8664 0 rs7701604 Imputed G ADDITIVE 1.27E−05 1.27E−05 0.2451 0.2451 0.6218 0 rs7701604 Imputed G DOMINANT 2.81E−05 2.81E−05 0.2509 0.2509 0.6535 0 rs7703676 Imputed C ADDITIVE 1.27E−05 1.27E−05 0.2451 0.2451 0.6218 0 rs7703676 Imputed C DOMINANT 2.81E−05 2.81E−05 0.2509 0.2509 0.6535 0 rs7708491 Imputed C RECESSIVE 6.44E−05 6.44E−05 0.5582 0.5582 0.823 0 rs7711358 Imputed A DOMINANT 0.0005772 0.0005772 0.6679 0.6679 0.7414 0 rs7719448 Imputed G RECESSIVE 3.03E−05 3.03E−05 0.5422 0.5422 0.7436 0 rs7724761 Imputed T RECESSIVE 2.79E−05 2.79E−05 0.5376 0.5376 0.8521 0 rs7742476 Imputed T DOMINANT 9.96E−05 9.96E−05 1.6177 1.6177 0.3946 0 rs7762993 Imputed A ADDITIVE 9.68E−05 9.68E−05 1.5062 1.5062 0.5789 0 rs7762993 Imputed A DOMINANT 1.55E−05 1.55E−05 1.6955 1.6955 0.475 0 rs7767265 Imputed G ADDITIVE 1.02E−05 1.02E−05 1.5369 1.5369 0.4161 0 rs7767265 Imputed G DOMINANT 1.30E−06 1.30E−06 1.786 1.786 0.4646 0 rs7768128 Imputed G RECESSIVE 0.001331 0.001331 0.4131 0.4131 0.6812 0 rs7771264 Imputed T DOMINANT 6.68E−05 6.68E−05 0.6186 0.6186 0.338 0 rs7773151 Genotyped C DOMINANT 7.51E−05 7.51E−05 0.624 0.624 0.3194 0 rs7773210 Genotyped A DOMINANT 6.11E−05 6.11E−05 0.6205 0.6205 0.3365 0 rs7808536 Imputed G DOMINANT 0.0002477 0.003942 1.5602 1.593 0.1988 39.43 rs7843510 Genotyped G DOMINANT 9.47E−05 9.47E−05 1.6156 1.6156 0.9612 0 rs7894867 Imputed T DOMINANT 0.0002327 0.0002327 1.6763 1.6763 0.6457 0 rs7921834 Imputed C DOMINANT 0.0001474 0.0001474 1.5574 1.5574 0.6777 0 rs7939893 Imputed C ADDITIVE 0.001994 0.001994 0.7672 0.7672 0.4917 0 rs7939893 Imputed C DOMINANT 0.00178 0.00178 0.6939 0.6939 0.7543 0 rs7944513 Imputed T GENOTYPIC 3.70E−05 3.70E−05 3.1057 3.1057 0.4987 0 rs7944513 Imputed T RECESSIVE 6.05E−05 6.05E−05 2.9509 2.9509 0.4009 0 rs7949720 Imputed G ADDITIVE 6.02E−05 6.02E−05 0.5917 0.5917 0.6951 0 rs7949720 Imputed G DOMINANT 4.34E−05 4.34E−05 0.5526 0.5526 0.5364 0 rs7955901 Imputed C ADDITIVE 0.0005679 0.0005679 0.745 0.745 0.8856 0 rs7955901 Imputed C DOMINANT 0.0002109 0.0002109 0.6246 0.6246 0.7241 0 rs7956274 Imputed T ADDITIVE 0.000471 0.000471 0.7423 0.7423 0.7644 0 rs7956274 Imputed T DOMINANT 0.0001278 0.0001278 0.6144 0.6144 0.9458 0 rs7956274 Imputed T GENOTYPIC 0.001643 0.001643 0.582 0.582 0.6004 0 rs7957932 Imputed G ADDITIVE 0.001051 0.001051 0.7578 0.7578 0.8972 0 rs7957932 Imputed G DOMINANT 0.0001397 0.0001397 0.6136 0.6136 0.8447 0 rs7984504 Imputed C GENOTYPIC 9.33E−05 9.33E−05 2.1895 2.1895 0.8871 0 rs7999518 Imputed A RECESSIVE 0.003293 0.003293 0.6449 0.6449 0.9164 0 rs8026245 Imputed G GENOTYPIC 0.0001769 0.0001769 3.0849 3.0849 0.8542 0 rs8026245 Imputed G RECESSIVE 0.0001739 0.0001739 3.0436 3.0436 0.9473 0 rs8060725 Genotyped A ADDITIVE 0.001967 0.001967 0.7414 0.7414 0.74 0 rs8103016 Genotyped A ADDITIVE 1.97E−05 1.97E−05 1.5542 1.5542 0.8792 0 rs8103016 Genotyped A DOMINANT 5.37E−05 5.37E−05 1.6315 1.6315 0.8495 0 rs8104182 Imputed G ADDITIVE 8.91E−05 8.91E−05 1.5032 1.5032 0.628 0 rs8104182 Imputed G DOMINANT 0.000187 0.000187 1.5764 1.5764 0.6041 0 rs8129461 Imputed G ADDITIVE 0.001444 0.002668 0.4528 0.4555 0.2951 8.76 rs8129461 Imputed G DOMINANT 0.001188 0.01352 0.4307 0.4432 0.213 35.52 rs8130021 Imputed G ADDITIVE 0.001444 0.002668 0.4528 0.4555 0.2951 8.76 rs8130021 Imputed G DOMINANT 0.001188 0.01352 0.4307 0.4432 0.213 35.52 rs879961 Imputed T ADDITIVE 2.33E−05 2.33E−05 0.6659 0.6659 0.4449 0 rs879961 Imputed T DOMINANT 1.51E−05 1.51E−05 0.6005 0.6005 0.9844 0 rs906353 Imputed A DOMINANT 9.95E−05 9.95E−05 0.6352 0.6352 0.8067 0 rs915491 Imputed C DOMINANT 0.0002054 0.0002054 1.5426 1.5426 0.7028 0 rs915493 Imputed T DOMINANT 0.0002054 0.0002054 1.5426 1.5426 0.7028 0 rs915494 Imputed A ADDITIVE 0.001238 0.001238 1.3527 1.3527 0.6764 0 rs915494 Imputed A DOMINANT 0.0002045 0.0002045 1.5574 1.5574 0.5538 0 rs917295 Imputed G DOMINANT 0.0005579 0.0005579 0.6664 0.6664 0.9359 0 rs9284851 Imputed A GENOTYPIC 6.86E−05 6.86E−05 2.0519 2.0519 0.9886 0 rs9293464 Imputed T RECESSIVE 3.03E−05 3.03E−05 0.5422 0.5422 0.7436 0 rs9295154 Genotyped G DOMINANT 0.0003436 0.0007175 1.5908 1.5981 0.2899 10.73 rs9310221 Imputed A DOMINANT 6.72E−05 6.93E−05 1.6779 1.6777 0.3166 0.28 rs9310699 Genotyped T GENOTYPIC 7.91E−05 7.91E−05 2.0683 2.0683 0.8608 0 rs9310700 Imputed C ADDITIVE 8.64E−05 8.64E−05 1.4077 1.4077 0.7999 0 rs9310700 Imputed C GENOTYPIC 3.31E−05 3.31E−05 2.2015 2.2015 0.8601 0 rs9310701 Imputed G GENOTYPIC 7.67E−05 7.67E−05 2.0358 2.0358 0.8969 0 rs9310704 Imputed G GENOTYPIC 4.87E−05 4.87E−05 2.1011 2.1011 0.908 0 rs9319185 Imputed C GENOTYPIC 5.38E−05 5.38E−05 2.2836 2.2836 0.9842 0 rs9319186 Imputed T GENOTYPIC 7.93E−05 7.93E−05 2.2431 2.2431 0.9603 0 rs9327555 Imputed T DOMINANT 0.000699 0.000699 0.6712 0.6712 0.8706 0 rs9403367 Imputed C DOMINANT 6.11E−05 6.11E−05 0.6205 0.6205 0.3365 0 rs9419608 Imputed G RECESSIVE 4.08E−05 4.08E−05 1.7425 1.7425 0.608 0 rs9426437 Imputed T DOMINANT 5.00E−05 5.00E−05 0.607 0.607 0.4632 0 rs9454967 Imputed G DOMINANT 5.94E−05 5.94E−05 1.9576 1.9576 0.6125 0 rs9635511 Imputed T DOMINANT 7.73E−05 7.73E−05 0.618 0.618 0.4399 0 rs966583 Imputed A ADDITIVE 9.56E−05 9.56E−05 0.7127 0.7127 0.7413 0 rs966583 Imputed A DOMINANT 4.65E−05 4.65E−05 0.6082 0.6082 0.9923 0 rs980263 Imputed T GENOTYPIC 6.16E−05 6.16E−05 2.059 2.059 0.935 0 rs980264 Imputed T GENOTYPIC 6.16E−05 6.16E−05 2.059 2.059 0.935 0 rs9812206 Imputed G ADDITIVE 5.80E−06 5.80E−06 0.5122 0.5122 0.7976 0 rs9812206 Imputed G DOMINANT 4.29E−06 4.29E−06 0.4876 0.4876 0.9796 0 rs9813552 Imputed G ADDITIVE 4.13E−05 4.13E−05 0.5495 0.5495 0.7178 0 rs9813552 Imputed G DOMINANT 3.19E−05 3.19E−05 0.5265 0.5265 0.9286 0 rs9815037 Imputed T ADDITIVE 1.99E−05 1.99E−05 0.5261 0.5261 0.5342 0 rs9815037 Imputed T DOMINANT 1.13E−05 1.13E−05 0.4982 0.4982 0.7438 0 rs9819583 Imputed T GENOTYPIC 7.12E−05 7.12E−05 2.0778 2.0778 0.8761 0 rs9825349 Imputed A ADDITIVE 1.98E−05 1.98E−05 0.5259 0.5259 0.5483 0 rs9825349 Imputed A DOMINANT 1.13E−05 1.13E−05 0.4982 0.4982 0.7598 0 rs9833118 Imputed G ADDITIVE 9.63E−05 9.63E−05 1.3977 1.3977 0.6136 0 rs9833118 Imputed G GENOTYPIC 5.01E−05 5.01E−05 2.1101 2.1101 0.8729 0 rs9834217 Imputed T ADDITIVE 2.21E−05 2.21E−05 0.5279 0.5279 0.5562 0 rs9834217 Imputed T DOMINANT 1.26E−05 1.26E−05 0.5002 0.5002 0.7692 0 rs9838563 Imputed C GENOTYPIC 7.67E−05 7.67E−05 2.0358 2.0358 0.8969 0 rs9840460 Imputed T ADDITIVE 2.08E−05 2.08E−05 0.5268 0.5268 0.5431 0 rs9840460 Imputed T DOMINANT 1.18E−05 1.18E−05 0.499 0.499 0.7541 0 rs9840756 Imputed A ADDITIVE 2.08E−05 2.08E−05 0.5268 0.5268 0.5431 0 rs9840756 Imputed A DOMINANT 1.18E−05 1.18E−05 0.499 0.499 0.7541 0 rs9847999 Imputed C GENOTYPIC 9.15E−05 9.15E−05 2.0254 2.0254 0.9674 0 rs9864769 Imputed C GENOTYPIC 7.67E−05 7.67E−05 2.0358 2.0358 0.8969 0 rs9866421 Genotyped C RECESSIVE 0.0009027 0.0009027 0.6009 0.6009 0.4635 0 rs987296 Imputed T GENOTYPIC 7.90E−05 7.90E−05 2.0683 2.0683 0.8607 0 rs9881685 Imputed A ADDITIVE 5.80E−06 5.80E−06 0.5122 0.5122 0.7976 0 rs9881685 Imputed A DOMINANT 4.29E−06 4.29E−06 0.4876 0.4876 0.9796 0 rs992695 Imputed C ADDITIVE 2.92E−05 2.92E−05 0.6695 0.6695 0.4384 0 rs992695 Imputed C DOMINANT 2.06E−05 2.06E−05 0.6059 0.6059 0.9952 0 rs9936999 Imputed G DOMINANT 8.52E−05 8.52E−05 1.8486 1.8486 0.8612 0

TABLE 18 SNP rs # SOURCE ALLELE (A1) MODEL P P(R) OR OR(R) Q I rs77638540 Genotyped T DOMINANT 8.53E−05 8.53E−05 0.4412 0.4412 0.4473 0 rs72746987 Genotyped A DOMINANT 1.04E−03 0.07511 0.5034 0.4987 0.037 69.66 rs10021016 Genotyped G GENOTYPIC 1.77E−05 1.77E−05 2.4195 2.4195 0.946 0 rs10021016 Genotyped G RECESSIVE 3.95E−05 3.95E−05 2.2819 2.2819 0.9639 0 rs10051148 Imputed C DOMINANT 4.37E−05 4.37E−05 0.663 0.663 0.936 0 rs10054055 Imputed T DOMINANT 2.45E−05 2.45E−05 0.652 0.652 0.8092 0 rs10067895 Imputed A DOMINANT 2.54E−05 2.54E−05 0.6504 0.6504 0.7871 0 rs10100725 Imputed C DOMINANT 9.58E−04 0.1048 0.6943 0.7246 0.0468 67.33 rs10128531 Imputed T ADDITIVE 6.93E−05 6.93E−05 1.5153 1.5153 0.8693 0 rs10181743 Imputed G ADDITIVE 1.45E−04 7.58E−04 1.3254 1.3179 0.3011 16.69 rs10199127 Imputed T DOMINANT 3.21E−04 0.02399 1.4423 1.433 0.098 56.95 rs10270624 Imputed G DOMINANT 7.89E−05 7.89E−05 1.5242 1.5242 0.5064 0 rs1030006 Imputed G RECESSIVE 2.14E−03 0.1294 1.4544 1.4242 0.0332 70.63 rs1031811 Imputed A RECESSIVE 8.78E−05 8.78E−05 1.988 1.988 0.5276 0 rs10430870 Genotyped G GENOTYPIC 6.56E−05 6.56E−05 2.3812 2.3812 0.4518 0 rs10430870 Genotyped G RECESSIVE 9.42E−05 9.42E−05 2.2976 2.2976 0.5059 0 rs10469597 Imputed A GENOTYPIC 2.56E−04 7.98E−03 2.0793 2.008 0.1981 38.23 rs10469597 Imputed A RECESSIVE 1.31E−04 3.67E−04 2.1038 2.0871 0.3313 9.47 rs10478919 Imputed G DOMINANT 1.88E−05 1.88E−05 0.6481 0.6481 0.8316 0 rs10506623 Imputed C ADDITIVE 3.33E−05 3.33E−05 0.7343 0.7343 0.8201 0 rs10506623 Imputed C DOMINANT 2.58E−05 2.58E−05 0.6418 0.6418 0.8101 0 rs10506626 Imputed A ADDITIVE 1.01E−05 1.01E−05 0.7226 0.7226 0.6798 0 rs10506626 Imputed A DOMINANT 1.59E−06 1.59E−06 0.608 0.608 0.7968 0 rs10509477 Imputed T DOMINANT 2.98E−05 2.98E−05 1.5214 1.5214 0.7093 0 rs10517918 Imputed G RECESSIVE 6.32E−04 0.04182 1.5595 1.5312 0.0872 59.01 rs10517924 Imputed A RECESSIVE 3.69E−04 0.007266 1.5408 1.514 0.2104 35.84 rs10519362 Imputed G DOMINANT 9.95E−05 9.95E−05 1.5338 1.5338 0.9176 0 rs10520072 Imputed T DOMINANT 1.82E−05 1.82E−05 0.647 0.647 0.881 0 rs10737390 Imputed T DOMINANT 1.26E−03 1.43E−01 0.7118 0.7485 0.0363 69.84 rs10742851 Imputed T RECESSIVE 1.44E−02 3.23E−01 0.5988 0.593 0.0033 82.54 rs10743685 Imputed G GENOTYPIC 4.32E−05 4.32E−05 1.8534 1.8534 0.6642 0 rs10743685 Imputed G RECESSIVE 7.41E−05 7.41E−05 1.7214 1.7214 0.6436 0 rs10749293 Imputed G DOMINANT 1.17E−05 1.17E−05 1.5526 1.5526 0.866 0 rs10749294 Imputed A DOMINANT 6.69E−05 6.69E−05 1.4909 1.4909 0.8006 0 rs10753760 Imputed T ADDITIVE 1.83E−03 1.26E−01 1.2546 1.2395 0.0287 71.84 rs10753760 Imputed T GENOTYPIC 2.08E−03 1.35E−01 1.5862 1.5469 0.0269 72.33 rs10772362 Imputed T ADDITIVE 2.16E−05 2.16E−05 0.691 0.691 0.4243 0 rs10784891 Imputed C ADDITIVE 3.13E−05 3.13E−05 0.7354 0.7354 0.9449 0 rs10784891 Imputed C DOMINANT 6.41E−05 6.41E−05 0.6454 0.6454 0.7393 0 rs10784891 Imputed C GENOTYPIC 9.84E−05 9.84E−05 0.5575 0.5575 0.8437 0 rs10787923 Imputed G DOMINANT 1.08E−05 1.08E−05 1.556 1.556 0.8555 0 rs10787924 Imputed T DOMINANT 5.94E−05 5.94E−05 1.4953 1.4953 0.7873 0 rs10787949 Imputed A DOMINANT 5.22E−05 5.22E−05 1.503 1.503 0.7135 0 rs10787951 Imputed G DOMINANT 5.35E−05 5.35E−05 1.5021 1.5021 0.7092 0 rs10787983 Imputed C DOMINANT 5.23E−05 5.23E−05 1.5007 1.5007 0.7558 0 rs10794733 Imputed C ADDITIVE 7.05E−05 7.05E−05 0.7343 0.7343 0.7115 0 rs10818280 Imputed C DOMINANT 9.18E−05 9.18E−05 0.6734 0.6734 0.8782 0 rs10860586 Imputed A ADDITIVE 3.08E−03 0.1633 1.2361 1.2211 0.0224 73.69 rs10860586 Imputed A GENOTYPIC 3.00E−03 1.63E−01 1.5291 1.4908 0.0225 73.63 rs10870473 Imputed A ADDITIVE 3.61E−03 2.33E−01 0.6941 0.7378 0.0195 74.59 rs10870473 Imputed A DOMINANT 5.37E−03 4.68E−01 0.6441 0.7381 0.0016 84.48 rs10879240 Imputed C ADDITIVE 3.83E−05 3.83E−05 0.74 0.74 0.9636 0 rs10879240 Imputed C GENOTYPIC 9.34E−05 9.34E−05 0.5585 0.5585 0.7993 0 rs10879242 Imputed A ADDITIVE 4.26E−05 4.26E−05 0.7384 0.7384 0.8941 0 rs10879242 Imputed A DOMINANT 2.29E−05 2.29E−05 0.6402 0.6402 0.8341 0 rs10879245 Imputed G ADDITIVE 4.26E−05 4.26E−05 0.7384 0.7384 0.8941 0 rs10879245 Imputed G DOMINANT 2.29E−05 2.29E−05 0.6402 0.6402 0.8341 0 rs10879249 Imputed T ADDITIVE 2.01E−05 2.01E−05 0.7287 0.7287 0.7861 0 rs10879249 Imputed T DOMINANT 1.30E−05 1.30E−05 0.6335 0.6335 0.7421 0 rs10886429 Imputed A DOMINANT 6.44E−05 6.44E−05 1.4958 1.4958 0.6357 0 rs10886449 Imputed G DOMINANT 8.67E−05 8.67E−05 1.4833 1.4833 0.761 0 rs10886451 Imputed G DOMINANT 8.67E−05 8.67E−05 1.4833 1.4833 0.761 0 rs10886452 Imputed A DOMINANT 4.28E−05 4.28E−05 1.5097 1.5097 0.7458 0 rs10886456 Imputed G DOMINANT 8.67E−05 8.67E−05 1.4833 1.4833 0.761 0 rs10886463 Imputed C DOMINANT 5.51E−05 5.51E−05 1.5014 1.5014 0.737 0 rs10886465 Imputed A DOMINANT 3.16E−05 3.16E−05 1.5202 1.5202 0.6725 0 rs10886526 Imputed C DOMINANT 4.73E−05 4.73E−05 1.5047 1.5047 0.7756 0 rs10922903 Imputed C RECESSIVE 7.51E−04 0.04061 0.6326 0.6533 0.1055 55.53 rs10941126 Imputed G ADDITIVE 2.88E−03 0.1046 0.5269 0.4225 0.0055 80.81 rs10941126 Imputed G DOMINANT 5.93E−03 0.1502 0.5204 0.4449 0.0058 80.6 rs10947980 Imputed G ADDITIVE 0.0007135 0.04303 0.7602 0.7647 0.0779 60.82 rs11059376 Imputed T ADDITIVE 2.09E−04 2.16E−03 1.4335 1.4217 0.2602 25.72 rs11072995 Imputed T GENOTYPIC 5.56E−05 5.56E−05 2.911 2.911 0.7416 0 rs11072995 Imputed T RECESSIVE 8.05E−05 8.05E−05 2.8127 2.8127 0.7514 0 rs11081202 Genotyped G GENOTYPIC 4.78E−05 4.78E−05 2.2039 2.2039 0.4315 0 rs11081202 Genotyped G RECESSIVE 9.57E−06 9.57E−06 2.3008 2.3008 0.5359 0 rs110965 Imputed C GENOTYPIC 5.25E−05 5.42E−05 2.0397 2.04 0.3665 0.36 rs11124962 Imputed A DOMINANT 9.31E−05 9.31E−05 1.4868 1.4868 0.434 0 rs1116596 Imputed T DOMINANT 2.21E−05 2.21E−05 0.6501 0.6501 0.8309 0 rs11178531 Imputed A ADDITIVE 8.31E−05 8.31E−05 0.753 0.753 0.9192 0 rs11178531 Imputed A DOMINANT 4.55E−05 4.55E−05 0.64 0.64 0.9035 0 rs11178583 Imputed A ADDITIVE 2.33E−05 2.33E−05 0.7308 0.7308 0.7646 0 rs11178583 Imputed A DOMINANT 1.65E−05 1.65E−05 0.6373 0.6373 0.7197 0 rs11178589 Imputed T ADDITIVE 1.62E−05 1.62E−05 0.7264 0.7264 0.7893 0 rs11178589 Imputed T DOMINANT 1.26E−05 1.26E−05 0.6312 0.6312 0.7472 0 rs11178594 Imputed C ADDITIVE 2.03E−05 2.03E−05 0.7297 0.7297 0.8443 0 rs11178594 Imputed C DOMINANT 1.05E−05 1.05E−05 0.6313 0.6313 0.8109 0 rs11178602 Imputed T ADDITIVE 1.67E−05 1.67E−05 0.7273 0.7273 0.8496 0 rs11178602 Imputed T DOMINANT 7.52E−06 7.52E−06 0.6264 0.6264 0.7997 0 rs11178648 Imputed T ADDITIVE 2.57E−05 2.57E−05 0.7339 0.7339 0.8706 0 rs11178648 Imputed T DOMINANT 3.00E−06 3.00E−06 0.6155 0.6155 0.8521 0 rs11198877 Imputed T DOMINANT 4.14E−05 4.14E−05 1.5107 1.5107 0.7435 0 rs11198942 Imputed T DOMINANT 2.98E−05 2.98E−05 1.5214 1.5214 0.7093 0 rs11221075 Imputed A ADDITIVE 4.53E−05 4.53E−05 0.6241 0.6241 0.5015 0 rs11242020 Imputed T DOMINANT 1.95E−05 1.95E−05 0.6485 0.6485 0.8129 0 rs11242021 Imputed T DOMINANT 2.31E−05 2.31E−05 0.6505 0.6505 0.8585 0 rs11242022 Imputed T DOMINANT 2.55E−05 2.55E−05 0.6519 0.6519 0.8477 0 rs11242023 Imputed T DOMINANT 3.12E−05 3.12E−05 0.6547 0.6547 0.8417 0 rs1149349 Imputed T DOMINANT 0.0001762 0.0002852 1.5177 1.5147 0.3503 4.68 rs1149350 Imputed A ADDITIVE 0.004059 0.341 1.2908 1.2455 0.0015 84.55 rs1149350 Imputed A DOMINANT 2.56E−04 1.03E−01 1.4706 1.4199 0.0201 74.39 rs11576627 Imputed T ADDITIVE 3.90E−05 3.90E−05 1.5393 1.5393 0.6597 0 rs11576627 Imputed T DOMINANT 2.57E−05 2.57E−05 1.6368 1.6368 0.6902 0 rs11630050 Imputed G GENOTYPIC 7.79E−05 7.79E−05 2.665 2.665 0.6771 0 rs11630050 Imputed G RECESSIVE 8.54E−05 8.54E−05 2.6107 2.6107 0.6577 0 rs11633024 Imputed C GENOTYPIC 7.79E−05 7.79E−05 2.665 2.665 0.6771 0 rs11633024 Imputed C RECESSIVE 8.54E−05 8.54E−05 2.6107 2.6107 0.6577 0 rs11636298 Imputed G GENOTYPIC 4.65E−05 4.65E−05 2.9093 2.9093 0.6341 0 rs11636298 Imputed G RECESSIVE 7.67E−05 7.67E−05 2.7833 2.7833 0.6295 0 rs11637363 Imputed C GENOTYPIC 4.03E−05 4.03E−05 2.7783 2.7783 0.6785 0 rs11637363 Imputed C RECESSIVE 4.23E−05 4.23E−05 2.7253 2.7253 0.6672 0 rs11637813 Imputed A GENOTYPIC 7.79E−05 7.79E−05 2.665 2.665 0.6771 0 rs11637813 Imputed A RECESSIVE 8.54E−05 8.54E−05 2.6107 2.6107 0.6577 0 rs11638043 Imputed C GENOTYPIC 6.02E−05 6.02E−05 2.6802 2.6802 0.7627 0 rs11638043 Imputed C RECESSIVE 6.43E−05 6.43E−05 2.6274 2.6274 0.7406 0 rs11638115 Imputed A GENOTYPIC 5.56E−05 5.56E−05 2.911 2.911 0.7416 0 rs11638115 Imputed A RECESSIVE 8.05E−05 8.05E−05 2.8127 2.8127 0.7514 0 rs11638444 Imputed C GENOTYPIC 8.18E−05 8.18E−05 2.781 2.781 0.5241 0 rs11682946 Imputed A ADDITIVE 2.15E−05 2.15E−05 4.6724 4.6724 0.6013 0 rs11682946 Imputed A DOMINANT 2.84E−05 2.84E−05 4.7413 4.7413 0.5763 0 rs11717157 Imputed T ADDITIVE 3.66E−04 4.28E−03 1.3013 1.2939 0.2362 30.7 rs11717157 Imputed T GENOTYPIC 4.70E−04 0.02682 1.7552 1.6884 0.1274 51.46 rs11724055 Imputed A DOMINANT 5.58E−05 5.58E−05 0.6449 0.6449 0.4625 0 rs11743355 Imputed C ADDITIVE 3.93E−03 1.07E−01 0.5325 0.414 0.005 81.12 rs11743355 Imputed C DOMINANT 7.85E−03 1.52E−01 0.5256 0.4354 0.0052 80.99 rs11746806 Imputed T ADDITIVE 2.88E−03 1.05E−01 0.5269 0.4225 0.0055 80.81 rs11746806 Imputed T DOMINANT 5.93E−03 1.50E−01 0.5204 0.4449 0.0058 80.6 rs11746959 Imputed T ADDITIVE 2.88E−03 0.1046 0.5269 0.4225 0.0055 80.81 rs11746959 Imputed T DOMINANT 5.93E−03 1.50E−01 0.5204 0.4449 0.0058 80.6 rs11749272 Imputed T DOMINANT 1.88E−05 1.88E−05 0.6481 0.6481 0.8316 0 rs11839636 Imputed C GENOTYPIC 3.90E−03 2.09E−01 1.6569 1.5719 0.0165 75.65 rs11839785 Imputed C GENOTYPIC 4.03E−03 2.10E−01 1.6541 1.57 0.0167 75.56 rs11853619 Imputed C GENOTYPIC 5.35E−05 5.35E−05 2.8832 2.8832 0.6237 0 rs11853619 Imputed C RECESSIVE 8.59E−05 8.59E−05 2.7639 2.7639 0.6266 0 rs11856780 Imputed A GENOTYPIC 5.35E−05 5.35E−05 2.8832 2.8832 0.6237 0 rs11856780 Imputed A RECESSIVE 8.59E−05 8.59E−05 2.7639 2.7639 0.6266 0 rs11901899 Imputed A DOMINANT 5.52E−05 5.52E−05 1.5083 1.5083 0.5339 0 rs11903290 Imputed C RECESSIVE 9.00E−05 9.00E−05 1.9859 1.9859 0.5245 0 rs11909480 Imputed G ADDITIVE 9.50E−05 9.50E−05 0.4368 0.4368 0.6169 0 rs11909480 Imputed G DOMINANT 7.23E−05 7.23E−05 0.418 0.418 0.5676 0 rs11910289 Imputed T ADDITIVE 8.16E−05 8.16E−05 1.8423 1.8423 0.8017 0 rs11910289 Imputed T DOMINANT 9.10E−05 9.10E−05 1.904 1.904 0.8708 0 rs11920375 Genotyped C GENOTYPIC 7.95E−04 4.33E−02 1.703 1.6282 0.1117 54.37 rs11926319 Imputed G DOMINANT 7.96E−04 0.02707 0.6352 0.6499 0.1381 49.5 rs11933744 Imputed T RECESSIVE 3.12E−03 0.1216 1.7872 1.8072 0.0315 71.09 rs11934919 Imputed C RECESSIVE 3.17E−03 0.1247 1.7868 1.804 0.0307 71.3 rs11934957 Imputed C RECESSIVE 3.17E−03 0.1247 1.7868 1.804 0.0307 71.3 rs11959206 Imputed A RECESSIVE 1.87E−03 0.191 0.678 0.7117 0.0177 75.21 rs12038613 Imputed C RECESSIVE 3.47E−04 0.01168 0.613 0.6271 0.1717 43.24 rs12151417 Imputed T DOMINANT 6.25E−05 6.25E−05 1.506 1.506 0.9573 0 rs12153185 Imputed T DOMINANT 2.47E−05 2.47E−05 0.6504 0.6504 0.757 0 rs12182651 Imputed T DOMINANT 8.64E−04 5.43E−02 1.5996 1.5843 0.071 62.2 rs12235345 Imputed C DOMINANT 6.65E−05 6.65E−05 1.8285 1.8285 0.4602 0 rs12324786 Imputed T GENOTYPIC 5.56E−05 5.56E−05 2.911 2.911 0.7416 0 rs12324786 Imputed T RECESSIVE 8.05E−05 8.05E−05 2.8127 2.8127 0.7514 0 rs12336958 Imputed G DOMINANT 4.62E−03 2.90E−01 1.3599 1.2903 0.009 78.77 rs12407412 Imputed C ADDITIVE 4.55E−05 4.55E−05 1.5333 1.5333 0.6371 0 rs12407412 Imputed C DOMINANT 3.07E−05 3.07E−05 1.6289 1.6289 0.6561 0 rs12418971 Imputed C GENOTYPIC 3.47E−05 3.47E−05 2.4809 2.4809 0.4834 0 rs12418971 Imputed C RECESSIVE 6.71E−05 6.71E−05 2.3563 2.3563 0.5471 0 rs1241967 Imputed T RECESSIVE 7.19E−05 7.19E−05 0.5103 0.5103 0.3812 0 rs12420184 Imputed G DOMINANT 9.08E−03 4.26E−01 0.7449 0.7927 0.0017 84.33 rs12433968 Imputed T DOMINANT 7.59E−04 1.18E−01 0.707 0.741 0.0375 69.54 rs12445477 Imputed A DOMINANT 6.41E−05 8.38E−05 0.5585 0.5583 0.357 2.92 rs12447191 Genotyped T ADDITIVE 8.95E−05 8.95E−05 0.6925 0.6925 0.818 0 rs12447191 Genotyped T DOMINANT 5.17E−05 5.17E−05 0.6473 0.6473 0.3993 0 rs12465349 Imputed A RECESSIVE 3.69E−05 3.69E−05 1.6009 1.6009 0.6932 0 rs1247340 Imputed C ADDITIVE 7.69E−03 3.65E−01 1.2697 1.2218 0.0029 82.86 rs1247340 Imputed C DOMINANT 0.0003633 0.0921 1.4554 1.406 0.0314 71.11 rs1247341 Imputed C ADDITIVE 0.006355 0.3353 1.2777 1.2307 0.004 81.86 rs1247341 Imputed C DOMINANT 3.13E−04 0.07821 1.4625 1.4174 0.0367 69.74 rs1247343 Imputed C DOMINANT 3.36E−04 7.38E−03 1.4916 1.47 0.2058 36.74 rs12509758 Imputed C DOMINANT 6.36E−05 6.36E−05 1.5131 1.5131 0.4849 0 rs12515472 Imputed A DOMINANT 9.90E−05 9.90E−05 1.5106 1.5106 0.3966 0 rs12548906 Imputed G ADDITIVE 4.27E−05 4.27E−05 1.4718 1.4718 0.4259 0 rs12596240 Imputed G DOMINANT 1.60E−04 0.003727 0.6751 0.6862 0.2247 33.03 rs12618781 Imputed A DOMINANT 1.01E−03 0.07896 0.6934 0.7084 0.0532 65.92 rs12678600 Imputed A DOMINANT 5.24E−05 5.24E−05 0.665 0.665 0.5424 0 rs12692229 Imputed T ADDITIVE 6.42E−05 6.42E−05 1.3491 1.3491 0.3777 0 rs12713324 Imputed T DOMINANT 6.12E−05 6.12E−05 1.5047 1.5047 0.9505 0 rs12719415 Imputed T DOMINANT 2.31E−05 2.31E−05 0.6505 0.6505 0.8585 0 rs12820589 Imputed G ADDITIVE 1.70E−03 1.48E−01 1.3433 1.3243 0.0167 75.57 rs12820589 Imputed G DOMINANT 1.50E−03 9.38E−02 1.4056 1.3931 0.0399 68.95 rs12831292 Imputed G ADDITIVE 2.24E−05 2.24E−05 0.7299 0.7299 0.8379 0 rs12831292 Imputed G DOMINANT 1.03E−05 1.03E−05 0.6291 0.6291 0.7999 0 rs13012636 Imputed G RECESSIVE 7.97E−05 7.97E−05 1.996 1.996 0.5232 0 rs13038146 Imputed C ADDITIVE 1.20E−05 1.20E−05 1.3766 1.3766 0.9732 0 rs13038146 Imputed C GENOTYPIC 7.24E−06 7.24E−06 2.0174 2.0174 0.8918 0 rs13038146 Imputed C RECESSIVE 6.47E−05 6.47E−05 1.7879 1.7879 0.5965 0 rs13089860 Imputed A DOMINANT 8.44E−05 8.44E−05 0.6273 0.6273 0.9636 0 rs13102419 Imputed T RECESSIVE 2.95E−04 0.003722 1.5536 1.5326 0.2434 29.22 rs13194907 Imputed A ADDITIVE 4.90E−04 0.01486 1.6504 1.6306 0.1555 46.27 rs13194907 Imputed A DOMINANT 0.0002179 0.004282 1.7592 1.7417 0.2106 35.82 rs13195745 Imputed A ADDITIVE 5.08E−04 1.48E−02 1.6483 1.629 0.1573 45.94 rs13195745 Imputed A DOMINANT 2.27E−04 4.24E−03 1.7567 1.7397 0.2126 35.41 rs13265054 Imputed T DOMINANT 5.66E−05 5.66E−05 0.6647 0.6647 0.7133 0 rs13273002 Imputed A GENOTYPIC 4.84E−04 1.49E−02 0.3723 0.3925 0.1872 40.32 rs13282131 Imputed C ADDITIVE 3.71E−05 3.71E−05 1.3435 1.3435 0.8944 0 rs13282131 Imputed C GENOTYPIC 1.60E−05 1.60E−05 1.8634 1.8634 0.9531 0 rs13282131 Imputed C RECESSIVE 3.52E−05 3.52E−05 1.6677 1.6677 0.8497 0 rs1330052 Imputed G GENOTYPIC 4.52E−03 2.69E−01 1.5788 1.4648 0.0124 77.22 rs1335721 Imputed A RECESSIVE 3.43E−04 1.13E−02 0.6128 0.6267 0.1732 42.96 rs1336382 Imputed T DOMINANT 3.16E−05 3.16E−05 1.5202 1.5202 0.7133 0 rs1336383 Imputed T DOMINANT 2.98E−05 2.98E−05 1.5214 1.5214 0.7093 0 rs1336407 Imputed T DOMINANT 4.97E−05 4.97E−05 1.5023 1.5023 0.7397 0 rs1336409 Imputed T DOMINANT 4.97E−05 4.97E−05 1.5023 1.5023 0.7397 0 rs1336596 Imputed A DOMINANT 0.0001018 0.03965 0.6696 0.6977 0.0654 63.33 rs13387284 Imputed A DOMINANT 8.75E−04 0.08529 0.688 0.7034 0.044 67.99 rs13401462 Imputed C DOMINANT 3.10E−04 1.15E−01 1.5296 1.4898 0.0127 77.09 rs13409045 Imputed T ADDITIVE 1.07E−03 4.28E−02 0.786 0.7926 0.0962 57.29 rs1349284 Imputed C GENOTYPIC 0.00058 0.0204 1.7388 1.6882 0.1518 46.96 rs1355715 Imputed T ADDITIVE 9.33E−05 9.33E−05 0.5378 0.5378 0.685 0 rs1357696 Imputed A GENOTYPIC 0.0009292 0.05615 1.6955 1.6136 0.0952 57.47 rs1357698 Imputed A GENOTYPIC 8.00E−04 4.78E−02 1.7026 1.6275 0.1002 56.54 rs1357699 Imputed T GENOTYPIC 0.0008002 0.04784 1.7026 1.6275 0.1002 56.54 rs1363273 Imputed C RECESSIVE 5.45E−04 1.84E−02 0.6477 0.6596 0.1541 46.53 rs1373601 Imputed A DOMINANT 2.77E−04 0.01048 0.6816 0.6853 0.1561 46.15 rs1375829 Imputed C GENOTYPIC 5.80E−04 0.0204 1.7388 1.6882 0.1518 46.96 rs1395748 Imputed G DOMINANT 4.33E−03 2.60E−01 0.7518 0.7852 0.0125 77.17 rs1414865 Imputed T DOMINANT 5.22E−05 5.22E−05 1.503 1.503 0.7135 0 rs1414873 Imputed A DOMINANT 4.97E−05 4.97E−05 1.5023 1.5023 0.7397 0 rs1414876 Imputed C DOMINANT 4.97E−05 4.97E−05 1.5023 1.5023 0.7397 0 rs1424643 Imputed G ADDITIVE 3.10E−05 3.10E−05 1.4271 1.4271 0.7865 0 rs1424643 Imputed G DOMINANT 1.30E−05 1.30E−05 1.5651 1.5651 0.8673 0 rs1424648 Imputed T DOMINANT 9.94E−05 9.94E−05 1.486 1.486 0.6958 0 rs1429321 Imputed A DOMINANT 7.77E−05 7.77E−05 1.4953 1.4953 0.9675 0 rs1429326 Imputed T ADDITIVE 9.21E−05 9.21E−05 1.399 1.399 0.8323 0 rs1429326 Imputed T DOMINANT 3.60E−05 3.60E−05 1.5277 1.5277 0.9565 0 rs1444741 Imputed A DOMINANT 2.75E−04 2.69E−02 0.6829 0.6887 0.0868 59.09 rs1449916 Imputed C DOMINANT 1.95E−05 1.95E−05 0.5625 0.5625 0.3711 0 rs1459523 Imputed A ADDITIVE 3.66E−04 4.28E−03 1.3013 1.2939 0.2362 30.7 rs1459523 Imputed A GENOTYPIC 4.70E−04 0.02682 1.7552 1.6884 0.1274 51.46 rs1466352 Imputed T GENOTYPIC 0.0005775 0.02214 1.7187 1.6652 0.1488 47.51 rs1466353 Imputed G GENOTYPIC 0.0005742 0.02215 1.7191 1.6655 0.1486 47.55 rs1476714 Imputed A DOMINANT 2.39E−05 2.39E−05 0.6504 0.6504 0.8559 0 rs1486723 Imputed C RECESSIVE 6.53E−05 6.53E−05 0.5173 0.5173 0.6824 0 rs1495375 Imputed A ADDITIVE 4.26E−05 4.26E−05 0.7384 0.7384 0.8941 0 rs1495375 Imputed A DOMINANT 2.29E−05 2.29E−05 0.6402 0.6402 0.8341 0 rs1495381 Imputed T GENOTYPIC 6.50E−05 6.50E−05 1.8347 1.8347 0.5926 0 rs1495381 Imputed T RECESSIVE 1.60E−05 1.60E−05 1.8065 1.8065 0.8326 0 rs1498061 Imputed C ADDITIVE 3.02E−05 3.02E−05 0.5576 0.5576 0.7263 0 rs1498992 Imputed G DOMINANT 3.76E−05 3.76E−05 0.6602 0.6602 0.6375 0 rs1499001 Imputed T DOMINANT 2.63E−05 2.63E−05 0.6507 0.6507 0.4397 0 rs1512988 Imputed A ADDITIVE 2.04E−05 2.04E−05 0.7286 0.7286 0.7895 0 rs1512988 Imputed A DOMINANT 1.46E−05 1.46E−05 0.6349 0.6349 0.7791 0 rs1512989 Imputed T ADDITIVE 2.04E−05 2.04E−05 0.7286 0.7286 0.7895 0 rs1512989 Imputed T DOMINANT 1.46E−05 1.46E−05 0.6349 0.6349 0.7791 0 rs1512991 Imputed T ADDITIVE 1.75E−05 1.75E−05 0.7317 0.7317 0.9424 0 rs1512991 Imputed T DOMINANT 2.76E−05 2.76E−05 0.6327 0.6327 0.8654 0 rs1512991 Imputed T GENOTYPIC 5.58E−05 5.58E−05 0.5525 0.5525 0.7914 0 rs1524303 Imputed T GENOTYPIC 0.0005851 0.02098 1.7312 1.675 0.1554 46.29 rs1524306 Imputed C ADDITIVE 0.000344 0.004662 1.3028 1.295 0.2276 32.44 rs1524306 Imputed C GENOTYPIC 4.48E−04 2.71E−02 1.7589 1.6915 0.1248 51.94 rs1524310 Imputed G ADDITIVE 2.72E−04 2.93E−03 1.3102 1.3039 0.2464 28.62 rs1524310 Imputed G GENOTYPIC 0.0003497 0.01684 1.7827 1.724 0.1509 47.13 rs1524321 Imputed C GENOTYPIC 3.30E−04 8.74E−03 1.772 1.7335 0.1931 39.2 rs1527059 Imputed A DOMINANT 6.83E−05 6.83E−05 0.577 0.577 0.3905 0 rs152707 Imputed A ADDITIVE 0.001601 0.1313 0.7957 0.8167 0.0376 69.53 rs152707 Imputed A GENOTYPIC 1.86E−03 1.35E−01 0.6257 0.6605 0.0389 69.2 rs152712 Genotyped C ADDITIVE 0.001213 0.1285 0.7908 0.812 0.0331 70.67 rs152712 Genotyped C GENOTYPIC 0.001349 0.1341 0.6169 0.6528 0.0328 70.74 rs1533994 Imputed T GENOTYPIC 0.0004988 0.02256 1.7311 1.674 0.142 48.77 rs1535866 Imputed G DOMINANT 9.86E−05 9.86E−05 1.4938 1.4938 0.5229 0 rs1563773 Imputed T GENOTYPIC 0.0006151 0.02321 1.7166 1.6611 0.1482 47.61 rs1563774 Imputed T GENOTYPIC 0.0006165 0.02322 1.7172 1.6635 0.1469 47.87 rs1567740 Imputed T ADDITIVE 1.99E−05 1.99E−05 0.7287 0.7287 0.7926 0 rs1567740 Imputed T DOMINANT 1.35E−05 1.35E−05 0.634 0.634 0.765 0 rs1572573 Imputed A DOMINANT 0.0004861 0.03203 1.4535 1.4085 0.1213 52.6 rs1577497 Imputed C RECESSIVE 0.000359 0.01133 0.6139 0.6277 0.1749 42.64 rs1581514 Imputed T ADDITIVE 0.0003311 0.003803 1.3057 1.2997 0.2373 30.49 rs1581514 Imputed T GENOTYPIC 0.0004261 0.02325 1.7652 1.7041 0.1328 50.48 rs1582321 Imputed T DOMINANT 0.0001513 0.003601 0.6742 0.6852 0.2244 33.07 rs1582322 Imputed A DOMINANT 0.0001591 0.0008772 0.674 0.6797 0.3001 16.91 rs1582323 Imputed A DOMINANT 0.0001659 0.001455 0.6747 0.6823 0.2779 21.9 rs1592485 Imputed C DOMINANT 0.000161 0.001019 0.6729 0.6792 0.294 18.31 rs1600954 Imputed T ADDITIVE 4.63E−05 4.63E−05 1.3445 1.3445 0.5721 0 rs1600954 Imputed T GENOTYPIC 4.57E−05 4.57E−05 1.8147 1.8147 0.542 0 rs16938626 Imputed G DOMINANT 3.76E−05 3.76E−05 0.659 0.659 0.6465 0 rs16964300 Imputed G ADDITIVE 6.56E−05 6.56E−05 0.6892 0.6892 0.8019 0 rs16964300 Imputed G DOMINANT 3.18E−05 3.18E−05 0.6401 0.6401 0.4292 0 rs16986282 Imputed G DOMINANT 4.72E−05 4.72E−05 0.4011 0.4011 0.3857 0 rs17007620 Imputed G ADDITIVE 0.00042 0.01992 1.3669 1.3587 0.1192 52.98 rs17007620 Imputed G DOMINANT 0.0001365 0.003601 1.5086 1.5037 0.1945 38.93 rs17014326 Imputed G DOMINANT 0.00215 0.2476 0.7351 0.7739 0.0097 78.44 rs17047957 Imputed C DOMINANT 3.23E−05 3.23E−05 1.5756 1.5756 0.7413 0 rs1705261 Imputed A RECESSIVE 2.52E−05 2.52E−05 1.7737 1.7737 0.834 0 rs17073341 Imputed A ADDITIVE 9.48E−05 9.48E−05 2.0844 2.0844 0.3839 0 rs17073341 Imputed A DOMINANT 7.90E−05 7.90E−05 2.1417 2.1417 0.3765 0 rs17138702 Imputed G ADDITIVE 0.004 0.216 0.7417 0.7591 0.0117 77.5 rs17189710 Imputed T ADDITIVE 1.26E−05 1.26E−05 1.3776 1.3776 0.9806 0 rs17189710 Imputed T GENOTYPIC 7.08E−06 7.08E−06 2.0265 2.0265 0.8812 0 rs17189710 Imputed T RECESSIVE 5.89E−05 5.89E−05 1.7991 1.7991 0.569 0 rs17310176 Imputed T ADDITIVE 6.02E−05 6.02E−05 0.6787 0.6787 0.5641 0 rs17310176 Imputed T DOMINANT 4.51E−05 4.51E−05 0.6409 0.6409 0.4149 0 rs17358860 Imputed A DOMINANT 5.45E−05 5.45E−05 0.6457 0.6457 0.4986 0 rs17370541 Imputed T GENOTYPIC 0.0003366 0.01452 1.7812 1.7046 0.176 42.44 rs17370541 Imputed T RECESSIVE 0.0002644 0.004097 1.7173 1.6801 0.2409 29.74 rs17526574 Imputed G GENOTYPIC 0.002555 0.1386 1.6824 1.6185 0.0319 70.98 rs17530747 Imputed T DOMINANT 0.0007294 0.06795 0.7034 0.7357 0.0872 59.01 rs17649114 Imputed C DOMINANT 5.86E−05 5.86E−05 1.5179 1.5179 0.5026 0 rs17766172 Imputed A RECESSIVE 4.67E−05 4.67E−05 0.4975 0.4975 0.483 0 rs1818885 Imputed G GENOTYPIC 0.0004892 0.02726 1.756 1.6897 0.1265 51.64 rs1832222 Imputed G DOMINANT 5.68E−05 5.68E−05 1.4978 1.4978 0.7483 0 rs1861327 Imputed G DOMINANT 0.0001308 0.002055 0.67 0.6796 0.2521 27.42 rs1868581 Imputed G ADDITIVE 0.0003858 0.009401 1.3009 1.2907 0.1844 40.85 rs1868581 Imputed G GENOTYPIC 0.0004728 0.03115 1.7583 1.6889 0.1157 53.63 rs1874313 Imputed A ADDITIVE 3.53E−05 3.53E−05 0.7362 0.7362 0.736 0 rs1874313 Imputed A DOMINANT 2.05E−05 2.05E−05 0.6403 0.6403 0.7327 0 rs1876409 Imputed C DOMINANT 0.003381 0.227 0.746 0.7766 0.0157 75.94 rs1913201 Imputed G ADDITIVE 2.15E−05 2.15E−05 0.7321 0.7321 0.9128 0 rs1913201 Imputed G DOMINANT 6.73E−05 6.73E−05 0.6474 0.6474 0.8659 0 rs1913201 Imputed G GENOTYPIC 6.26E−05 6.26E−05 0.5503 0.5503 0.7315 0 rs1916922 Imputed T GENOTYPIC 0.0006243 0.02368 1.7596 1.7018 0.1488 47.52 rs1936871 Genotyped G DOMINANT 8.55E−05 8.55E−05 0.6616 0.6616 0.3925 0 rs1961157 Imputed T RECESSIVE 0.002404 0.1282 0.68 0.6899 0.0283 71.94 rs1987179 Imputed T ADDITIVE 9.76E−05 9.76E−05 0.6985 0.6985 0.7616 0 rs1987179 Imputed T DOMINANT 6.37E−06 6.37E−06 0.6204 0.6204 0.6462 0 rs1990023 Imputed T DOMINANT 1.72E−05 1.72E−05 0.6468 0.6468 0.8317 0 rs1995025 Imputed C DOMINANT 7.87E−05 7.87E−05 1.5633 1.5633 0.7042 0 rs2016194 Imputed G DOMINANT 2.38E−05 2.38E−05 0.651 0.651 0.8576 0 rs2023651 Imputed T ADDITIVE 0.002541 0.2484 0.7624 0.7886 0.0082 79.2 rs2024902 Imputed A ADDITIVE 0.0005049 0.01577 1.6486 1.6285 0.152 46.92 rs2024902 Imputed A DOMINANT 0.0002252 0.004699 1.7569 1.739 0.2058 36.74 rs2025107 Imputed A DOMINANT 0.0008183 0.05061 1.6029 1.5881 0.0749 61.42 rs2025108 Imputed T DOMINANT 0.001038 0.04754 1.5831 1.5581 0.0932 57.86 rs2031987 Imputed T GENOTYPIC 0.002645 0.1394 1.6843 1.6228 0.0311 71.19 rs2052428 Imputed C DOMINANT 6.07E−05 6.07E−05 0.6359 0.6359 0.7925 0 rs2053230 Imputed C ADDITIVE 0.0001481 0.003644 0.6297 0.6429 0.2766 22.2 rs2062448 Imputed T DOMINANT 0.0003871 0.004058 0.6188 0.6264 0.2457 28.76 rs2063420 Imputed C RECESSIVE 0.001837 0.1146 1.4963 1.443 0.0468 67.35 rs2063591 Imputed C ADDITIVE 7.27E−05 7.27E−05 0.7518 0.7518 0.9305 0 rs2063591 Imputed C DOMINANT 4.26E−05 4.26E−05 0.6381 0.6381 0.8973 0 rs208026 Genotyped A DOMINANT 6.33E−05 6.33E−05 1.4986 1.4986 0.9606 0 rs208029 Imputed T DOMINANT 3.75E−05 3.75E−05 1.5349 1.5349 0.4541 0 rs208757 Imputed G DOMINANT 3.01E−05 3.01E−05 1.5343 1.5343 0.5566 0 rs2095586 Imputed A DOMINANT 3.68E−05 3.68E−05 1.5163 1.5163 0.6839 0 rs2095606 Imputed A DOMINANT 5.61E−05 0.01913 0.6593 0.6816 0.0926 57.97 rs2102374 Imputed A ADDITIVE 0.001363 0.2021 0.7686 0.7983 0.0117 77.54 rs2102374 Imputed A DOMINANT 0.001202 0.1846 0.7215 0.7489 0.0116 77.55 rs2108426 Imputed C DOMINANT 2.38E−05 2.38E−05 0.651 0.651 0.8576 0 rs2110664 Imputed A DOMINANT 3.76E−05 3.76E−05 1.532 1.532 0.6276 0 rs2132242 Imputed A ADDITIVE 1.93E−05 1.93E−05 0.7293 0.7293 0.8549 0 rs2132242 Imputed A DOMINANT 1.23E−05 1.23E−05 0.6323 0.6323 0.8457 0 rs2158958 Imputed A DOMINANT 2.31E−05 2.31E−05 0.6505 0.6505 0.8585 0 rs2158961 Imputed G DOMINANT 4.37E−05 4.37E−05 0.663 0.663 0.936 0 rs2163046 Imputed A DOMINANT 7.62E−05 7.62E−05 1.4981 1.4981 0.988 0 rs2180286 Imputed G DOMINANT 6.63E−05 6.63E−05 0.6345 0.6345 0.8013 0 rs2180684 Imputed A DOMINANT 2.68E−05 2.68E−05 1.7201 1.7201 0.9033 0 rs2188079 Imputed C ADDITIVE 0.0004508 0.01972 1.2881 1.2834 0.1244 52.01 rs2188079 Imputed C GENOTYPIC 0.0002443 0.007437 1.7178 1.7019 0.1776 42.15 rs2190598 Imputed T DOMINANT 2.31E−05 2.31E−05 0.6505 0.6505 0.8585 0 rs2190600 Imputed A DOMINANT 2.54E−05 2.54E−05 0.6504 0.6504 0.7871 0 rs2224184 Genotyped T DOMINANT 8.75E−05 8.75E−05 0.6414 0.6414 0.8155 0 rs2247066 Imputed A DOMINANT 0.004329 0.2604 0.7518 0.7852 0.0125 77.17 rs2248236 Imputed C ADDITIVE 2.90E−05 2.90E−05 0.676 0.676 0.7802 0 rs2248236 Imputed C DOMINANT 1.58E−06 1.58E−06 0.596 0.596 0.8313 0 rs2265733 Imputed C ADDITIVE 0.001363 0.2021 0.7686 0.7983 0.0117 77.54 rs2265733 Imputed C DOMINANT 0.001202 0.1846 0.7215 0.7489 0.0116 77.55 rs2270584 Imputed A ADDITIVE 2.02E−05 2.02E−05 0.7312 0.7312 0.8826 0 rs2270584 Imputed A DOMINANT 2.32E−06 2.32E−06 0.6123 0.6123 0.8509 0 rs2270586 Imputed A ADDITIVE 2.39E−05 2.39E−05 0.7334 0.7334 0.8691 0 rs2270586 Imputed A DOMINANT 3.16E−06 3.16E−06 0.6167 0.6167 0.8138 0 rs229775 Imputed A RECESSIVE 7.19E−05 7.19E−05 0.5103 0.5103 0.3812 0 rs229815 Imputed T RECESSIVE 9.48E−05 9.48E−05 0.5099 0.5099 0.5285 0 rs229829 Imputed C RECESSIVE 9.98E−05 9.98E−05 0.5548 0.5548 0.8369 0 rs229831 Imputed A RECESSIVE 8.91E−05 8.91E−05 0.5096 0.5096 0.3946 0 rs2317057 Imputed T ADDITIVE 6.41E−05 6.41E−05 0.6839 0.6839 0.7046 0 rs2322100 Genotyped T RECESSIVE 4.07E−05 4.07E−05 2.2062 2.2062 0.5484 0 rs2322101 Imputed A RECESSIVE 3.66E−05 3.66E−05 2.218 2.218 0.5273 0 rs2327929 Imputed G RECESSIVE 3.43E−05 3.43E−05 1.6873 1.6873 0.4473 0 rs2332844 Imputed A ADDITIVE 3.09E−05 3.09E−05 1.6598 1.6598 0.5134 0 rs2332844 Imputed A RECESSIVE 6.54E−05 6.54E−05 1.7248 1.7248 0.7183 0 rs2349170 Imputed G DOMINANT 9.67E−05 9.67E−05 1.4926 1.4926 0.6711 0 rs2356722 Imputed G DOMINANT 0.002651 0.2845 0.7401 0.7804 0.0062 80.31 rs2364956 Imputed T ADDITIVE 0.000127 0.0002252 1.4305 1.4298 0.3433 6.47 rs2373793 Imputed G ADDITIVE 4.62E−05 4.62E−05 1.4791 1.4791 0.7939 0 rs2373793 Imputed G DOMINANT 2.34E−05 2.34E−05 1.5985 1.5985 0.6098 0 rs238252 Imputed G ADDITIVE 8.76E−05 0.0001795 1.4845 1.4806 0.3424 6.69 rs238252 Imputed G DOMINANT 6.01E−05 0.0004281 1.5806 1.5679 0.292 18.76 rs2383903 Imputed G DOMINANT 4.71E−05 4.71E−05 0.6638 0.6638 0.7307 0 rs2387945 Imputed G DOMINANT 7.60E−05 7.60E−05 1.5615 1.5615 0.6844 0 rs2389863 Imputed A DOMINANT 1.22E−05 1.22E−05 0.6334 0.6334 0.7957 0 rs2389866 Imputed C DOMINANT 4.66E−06 4.66E−06 0.6225 0.6225 0.7145 0 rs2389869 Imputed C DOMINANT 4.66E−06 4.66E−06 0.6225 0.6225 0.7145 0 rs2389870 Genotyped C DOMINANT 6.46E−05 6.46E−05 0.6493 0.6493 0.3855 0 rs2418494 Imputed G ADDITIVE 9.79E−05 9.79E−05 0.7569 0.7569 0.5664 0 rs2418494 Imputed G GENOTYPIC 9.28E−05 9.28E−05 0.5712 0.5712 0.5491 0 rs2418541 Imputed A DOMINANT 1.72E−05 1.72E−05 0.6468 0.6468 0.8317 0 rs2418542 Imputed A DOMINANT 1.88E−05 1.88E−05 0.6481 0.6481 0.8316 0 rs2423556 Imputed C DOMINANT 7.99E−05 7.99E−05 0.635 0.635 0.8112 0 rs2437688 Imputed C ADDITIVE 7.95E−05 7.95E−05 1.591 1.591 0.4782 0 rs2456809 Imputed G DOMINANT 0.002716 0.1918 0.7406 0.7699 0.0226 73.61 rs2456811 Imputed T ADDITIVE 0.001617 0.2162 0.7717 0.802 0.0106 77.99 rs2456811 Imputed T DOMINANT 0.001438 0.1994 0.7251 0.7532 0.0104 78.1 rs2476976 Imputed C DOMINANT 6.91E−05 6.91E−05 1.4908 1.4908 0.8073 0 rs2484911 Imputed A DOMINANT 9.19E−05 9.19E−05 1.4801 1.4801 0.8339 0 rs2488557 Imputed C DOMINANT 0.000454 0.009593 0.6571 0.6684 0.1949 38.85 rs250162 Imputed C ADDITIVE 7.89E−06 7.89E−06 0.6754 0.6754 0.5537 0 rs250162 Imputed C DOMINANT 3.91E−06 3.91E−06 0.6207 0.6207 0.4842 0 rs2560708 Imputed T ADDITIVE 8.04E−05 8.04E−05 0.6746 0.6746 0.7071 0 rs2617841 Imputed G DOMINANT 7.42E−05 7.42E−05 0.6584 0.6584 0.6003 0 rs2622499 Imputed G DOMINANT 5.66E−06 5.66E−06 0.6251 0.6251 0.6966 0 rs264129 Imputed T DOMINANT 4.75E−05 4.75E−05 0.6631 0.6631 0.9256 0 rs2642936 Imputed T ADDITIVE 0.0008203 0.04658 1.3495 1.3354 0.0879 58.88 rs2660633 Imputed A DOMINANT 0.003381 0.227 0.746 0.7766 0.0157 75.94 rs2660634 Imputed C DOMINANT 0.003381 0.227 0.746 0.7766 0.0157 75.94 rs2660648 Imputed A ADDITIVE 0.001363 0.2021 0.7686 0.7983 0.0117 77.54 rs2660648 Imputed A DOMINANT 0.001202 0.1846 0.7215 0.7489 0.0116 77.55 rs2681505 Imputed T ADDITIVE 2.69E−05 2.69E−05 0.6941 0.6941 0.3782 0 rs277411 Imputed G DOMINANT 0.002587 0.1087 0.5246 0.4938 0.0195 74.6 rs2832634 Imputed G ADDITIVE 9.75E−05 9.75E−05 1.8259 1.8259 0.7829 0 rs2832637 Imputed T ADDITIVE 9.75E−05 9.75E−05 1.8259 1.8259 0.7829 0 rs2843167 Imputed A DOMINANT 0.001237 0.1278 0.7224 0.7509 0.0362 69.86 rs2876227 Imputed C ADDITIVE 2.82E−05 2.82E−05 1.362 1.362 0.97 0 rs2876227 Imputed C GENOTYPIC 1.54E−05 1.54E−05 1.9854 1.9854 0.8563 0 rs2882097 Imputed A DOMINANT 2.98E−05 2.98E−05 1.5214 1.5214 0.7093 0 rs2909862 Imputed G DOMINANT 0.0004342 0.0219 1.5096 1.4698 0.1401 49.11 rs3001945 Imputed T DOMINANT 7.34E−05 7.34E−05 1.5785 1.5785 0.8106 0 rs3011020 Imputed C DOMINANT 7.27E−05 7.27E−05 1.5634 1.5634 0.6833 0 rs36071725 Genotyped C ADDITIVE 0.0001148 0.05399 1.3419 1.3062 0.0432 68.17 rs36071725 Genotyped C GENOTYPIC 0.0001469 0.1424 1.9245 1.7281 0.0116 77.56 rs373983 Imputed G DOMINANT 2.26E−05 2.26E−05 1.5782 1.5782 0.441 0 rs3743794 Imputed G DOMINANT 0.0002394 0.002286 0.6809 0.6895 0.2695 23.73 rs3756154 Imputed C ADDITIVE 8.74E−05 8.74E−05 0.6973 0.6973 0.7453 0 rs3756154 Imputed C DOMINANT 5.57E−06 5.57E−06 0.6194 0.6194 0.6345 0 rs3775850 Imputed A DOMINANT 4.28E−05 4.28E−05 0.6406 0.6406 0.4572 0 rs3775851 Imputed C DOMINANT 5.58E−05 5.58E−05 0.6449 0.6449 0.4625 0 rs3793044 Imputed C ADDITIVE 0.0006211 0.01526 1.6363 1.6145 0.1659 44.33 rs3793044 Imputed C DOMINANT 0.0002821 0.004123 1.7429 1.7248 0.2257 32.82 rs3793053 Imputed C DOMINANT 0.0006344 0.04352 1.6268 1.6074 0.0815 60.12 rs3796246 Imputed G DOMINANT 0.0006434 0.02777 0.6293 0.6362 0.1152 53.73 rs3806003 Imputed A ADDITIVE 0.0006211 0.01526 1.6363 1.6145 0.1659 44.33 rs3806003 Imputed A DOMINANT 0.0002821 0.004123 1.7429 1.7248 0.2257 32.82 rs3806004 Imputed T DOMINANT 0.0008183 0.05061 1.6029 1.5881 0.0749 61.42 rs3806010 Imputed T DOMINANT 0.0008183 0.05061 1.6029 1.5881 0.0749 61.42 rs3806014 Imputed T DOMINANT 0.0006528 0.0397 1.6219 1.6045 0.0892 58.62 rs3806015 Imputed A DOMINANT 0.0007014 0.04258 1.6162 1.5981 0.0866 59.13 rs3806018 Imputed A DOMINANT 0.001012 0.05137 1.5918 1.5803 0.0785 60.71 rs3806019 Imputed A DOMINANT 0.0009044 0.0577 1.5971 1.581 0.0678 62.83 rs3806024 Imputed T DOMINANT 0.0006532 0.0428 1.619 1.6067 0.0793 60.54 rs3915080 Imputed A GENOTYPIC 0.0006483 0.0458 1.7202 1.6467 0.095 57.52 rs3942254 Imputed T ADDITIVE 2.13E−05 2.13E−05 0.7274 0.7274 0.9089 0 rs3942254 Imputed T DOMINANT 9.53E−06 9.53E−06 0.6253 0.6253 0.9519 0 rs3945085 Imputed A DOMINANT 3.27E−05 3.27E−05 1.519 1.519 0.687 0 rs3976737 Imputed G ADDITIVE 0.003945 0.2806 0.7457 0.7798 0.0081 79.23 rs399485 Imputed A DOMINANT 4.97E−05 4.97E−05 1.5032 1.5032 0.8617 0 rs4029119 Imputed G ADDITIVE 0.004166 0.1177 0.5395 0.4424 0.0069 79.92 rs4029119 Imputed G DOMINANT 0.008687 0.1677 0.5356 0.4664 0.0072 79.71 rs4076201 Imputed G GENOTYPIC 5.99E−05 5.99E−05 2.6809 2.6809 0.7622 0 rs4076201 Imputed G RECESSIVE 6.53E−05 6.53E−05 2.6253 2.6253 0.7419 0 rs41395945 Imputed G ADDITIVE 7.48E−05 7.48E−05 1.8482 1.8482 0.7926 0 rs41395945 Imputed G DOMINANT 8.37E−05 8.37E−05 1.9099 1.9099 0.8616 0 rs4146972 Genotyped T DOMINANT 3.95E−05 3.95E−05 1.5614 1.5614 0.6547 0 rs4238087 Imputed G DOMINANT 9.82E−05 9.82E−05 0.6268 0.6268 0.5018 0 rs4251569 Imputed T ADDITIVE 9.93E−05 9.93E−05 0.6551 0.6551 0.6066 0 rs4251569 Imputed T DOMINANT 8.05E−05 8.05E−05 0.6254 0.6254 0.4972 0 rs4273613 Imputed T ADDITIVE 0.002876 0.1046 0.5269 0.4225 0.0055 80.81 rs4273613 Imputed T DOMINANT 0.005931 0.1502 0.5204 0.4449 0.0058 80.6 rs4291049 Imputed T RECESSIVE 0.002115 0.1545 0.6826 0.7124 0.0331 70.66 rs4315598 Imputed T ADDITIVE 1.33E−05 1.33E−05 1.3742 1.3742 0.9673 0 rs4315598 Imputed T GENOTYPIC 8.02E−06 8.02E−06 2.0108 2.0108 0.8929 0 rs4315598 Imputed T RECESSIVE 6.81E−05 6.81E−05 1.7847 1.7847 0.5993 0 rs4321395 Imputed A DOMINANT 0.0008748 0.08529 0.688 0.7034 0.044 67.99 rs4321596 Genotyped T RECESSIVE 9.95E−05 9.95E−05 2.3838 2.3838 0.8271 0 rs4324417 Imputed T DOMINANT 0.0004684 0.01009 1.4729 1.4477 0.1952 38.79 rs4328619 Genotyped G DOMINANT 8.16E−05 8.16E−05 0.6393 0.6393 0.768 0 rs4338909 Imputed T ADDITIVE 0.0009962 0.03681 1.2613 1.2511 0.1094 54.81 rs4370878 Imputed G DOMINANT 5.08E−05 5.08E−05 1.5041 1.5041 0.6831 0 rs4379434 Genotyped T DOMINANT 0.0008974 0.03349 1.4182 1.3922 0.1216 52.53 rs4416407 Imputed T DOMINANT 7.89E−05 7.89E−05 1.6055 1.6055 0.6011 0 rs4417899 Imputed C RECESSIVE 7.35E−05 7.35E−05 0.6217 0.6217 0.5918 0 rs4442732 Imputed A ADDITIVE 0.0002973 0.01275 0.7154 0.7312 0.1721 43.17 rs4444612 Imputed G ADDITIVE 1.05E−05 1.05E−05 1.38 1.38 0.9803 0 rs4444612 Imputed G GENOTYPIC 6.88E−06 6.88E−06 2.022 2.022 0.8907 0 rs4444612 Imputed G RECESSIVE 6.51E−05 6.51E−05 1.7874 1.7874 0.5969 0 rs4450660 Imputed C DOMINANT 6.12E−05 6.12E−05 1.5007 1.5007 0.4999 0 rs4509702 Imputed C DOMINANT 5.08E−05 5.08E−05 1.5041 1.5041 0.6831 0 rs4526920 Imputed G GENOTYPIC 0.002645 0.1394 1.6843 1.6228 0.0311 71.19 rs4533145 Imputed T DOMINANT 0.06008 0.6325 0.7887 0.8292 0.0001 89.37 rs4557006 Imputed A DOMINANT 0.001528 0.089 0.6986 0.7133 0.0548 65.56 rs4570530 Imputed C DOMINANT 5.08E−05 5.08E−05 1.5041 1.5041 0.6831 0 rs4615971 Imputed C DOMINANT 4.82E−05 4.82E−05 1.5038 1.5038 0.7548 0 rs4628119 Imputed A DOMINANT 0.0009573 0.07481 0.7135 0.7203 0.0461 67.51 rs4664443 Imputed G ADDITIVE 0.0009373 0.04269 0.7841 0.7912 0.0927 57.96 rs4688259 Imputed T DOMINANT 7.88E−05 7.88E−05 1.6056 1.6056 0.5986 0 rs4688632 Imputed G RECESSIVE 4.49E−05 4.49E−05 0.6188 0.6188 0.7162 0 rs4695284 Imputed A ADDITIVE 6.68E−05 6.68E−05 1.8181 1.8181 0.5549 0 rs4700302 Imputed A ADDITIVE 0.002913 0.1394 0.6642 0.6808 0.0345 70.31 rs4702720 Imputed A ADDITIVE 4.29E−05 4.29E−05 0.6727 0.6727 0.6127 0 rs4702720 Imputed A DOMINANT 2.14E−05 2.14E−05 0.6116 0.6116 0.5842 0 rs4711091 Genotyped G GENOTYPIC 0.003111 0.235 1.5203 1.4091 0.02 74.42 rs4714484 Imputed A ADDITIVE 6.43E−05 0.0001399 0.6741 0.6745 0.3377 7.89 rs4736802 Imputed G DOMINANT 0.0007866 0.03886 1.4239 1.3953 0.1046 55.7 rs4760785 Imputed A ADDITIVE 2.15E−05 2.15E−05 0.7321 0.7321 0.9128 0 rs4760785 Imputed A DOMINANT 6.73E−05 6.73E−05 0.6474 0.6474 0.8659 0 rs4760785 Imputed A GENOTYPIC 6.26E−05 6.26E−05 0.5503 0.5503 0.7315 0 rs4760894 Imputed T ADDITIVE 2.15E−05 2.15E−05 0.7321 0.7321 0.9128 0 rs4760894 Imputed T DOMINANT 6.73E−05 6.73E−05 0.6474 0.6474 0.8659 0 rs4760894 Imputed T GENOTYPIC 6.26E−05 6.26E−05 0.5503 0.5503 0.7315 0 rs4760895 Imputed A ADDITIVE 2.15E−05 2.15E−05 0.7321 0.7321 0.9128 0 rs4760895 Imputed A DOMINANT 6.73E−05 6.73E−05 0.6474 0.6474 0.8659 0 rs4760895 Imputed A GENOTYPIC 6.26E−05 6.26E−05 0.5503 0.5503 0.7315 0 rs4764738 Imputed A ADDITIVE 0.0009266 0.07954 1.2709 1.2594 0.0439 68.01 rs4764738 Imputed A GENOTYPIC 0.001005 0.08625 1.6088 1.5782 0.0404 68.83 rs4764974 Imputed T ADDITIVE 0.003078 0.1633 1.2361 1.2211 0.0224 73.69 rs4764974 Imputed T GENOTYPIC 0.003002 0.1626 1.5291 1.4908 0.0225 73.63 rs4798366 Imputed G RECESSIVE 4.20E−05 4.20E−05 2.0082 2.0082 0.3989 0 rs483159 Imputed T DOMINANT 7.40E−05 7.40E−05 1.5348 1.5348 0.4489 0 rs4836502 Imputed T DOMINANT 2.31E−05 2.31E−05 0.6505 0.6505 0.8585 0 rs4836507 Imputed C DOMINANT 2.65E−05 2.65E−05 0.6512 0.6512 0.7993 0 rs4836744 Imputed A ADDITIVE 5.65E−05 5.65E−05 0.7302 0.7302 0.9215 0 rs4836744 Imputed A DOMINANT 9.27E−05 9.27E−05 0.6763 0.6763 0.9561 0 rs4848944 Genotyped C RECESSIVE 9.83E−05 9.83E−05 0.6206 0.6206 0.3871 0 rs4851529 Imputed A DOMINANT 2.19E−05 2.19E−05 0.6441 0.6441 0.7104 0 rs4851531 Imputed T DOMINANT 3.21E−05 3.21E−05 0.6474 0.6474 0.5448 0 rs4858046 Genotyped T GENOTYPIC 0.0006163 0.0233 1.7237 1.6703 0.1446 48.29 rs4878214 Imputed A ADDITIVE 3.88E−05 3.88E−05 0.6738 0.6738 0.5061 0 rs4880803 Imputed A ADDITIVE 9.69E−05 9.69E−05 0.7391 0.7391 0.6783 0 rs489441 Imputed G ADDITIVE 2.53E−05 2.53E−05 1.4225 1.4225 0.5025 0 rs489441 Imputed G DOMINANT 2.68E−05 2.68E−05 1.5463 1.5463 0.8089 0 rs4896568 Imputed T DOMINANT 0.001111 0.06921 0.7129 0.7224 0.06 64.45 rs4938851 Imputed T DOMINANT 3.87E−05 3.87E−05 1.5301 1.5301 0.5447 0 rs4964416 Imputed C DOMINANT 9.70E−05 9.70E−05 0.6422 0.6422 0.8344 0 rs5756669 Imputed C DOMINANT 0.0004684 0.01009 1.4729 1.4477 0.1952 38.79 rs6033138 Imputed C ADDITIVE 7.29E−06 7.29E−06 1.3851 1.3851 0.9889 0 rs6033138 Imputed C GENOTYPIC 6.04E−06 6.04E−06 2.0122 2.0122 0.8928 0 rs6033138 Imputed C RECESSIVE 7.08E−05 7.08E−05 1.7649 1.7649 0.6157 0 rs6040619 Imputed C ADDITIVE 4.47E−06 4.47E−06 1.3986 1.3986 0.8222 0 rs6040619 Imputed C GENOTYPIC 2.25E−06 2.25E−06 2.1003 2.1003 0.9241 0 rs6040619 Imputed C RECESSIVE 2.09E−05 2.09E−05 1.861 1.861 0.8676 0 rs6040625 Imputed T ADDITIVE 5.19E−06 5.19E−06 1.3953 1.3953 0.8592 0 rs6040625 Imputed T GENOTYPIC 3.08E−06 3.08E−06 2.0812 2.0812 0.9469 0 rs6040625 Imputed T RECESSIVE 3.05E−05 3.05E−05 1.8401 1.8401 0.8473 0 rs6040630 Imputed A ADDITIVE 9.20E−06 9.20E−06 1.383 1.383 0.9581 0 rs6040630 Imputed A GENOTYPIC 5.55E−06 5.55E−06 2.0375 2.0375 0.9148 0 rs6040630 Imputed A RECESSIVE 5.12E−05 5.12E−05 1.8039 1.8039 0.6621 0 rs6040633 Imputed A ADDITIVE 1.25E−05 1.25E−05 1.3756 1.3756 0.969 0 rs6040633 Imputed A GENOTYPIC 7.70E−06 7.70E−06 2.0134 2.0134 0.8921 0 rs6040633 Imputed A RECESSIVE 6.75E−05 6.75E−05 1.7849 1.7849 0.6011 0 rs6040634 Imputed T ADDITIVE 1.00E−05 1.00E−05 1.3804 1.3804 0.9666 0 rs6040634 Imputed T GENOTYPIC 6.55E−06 6.55E−06 2.0241 2.0241 0.8798 0 rs6040634 Imputed T RECESSIVE 6.47E−05 6.47E−05 1.7879 1.7879 0.5965 0 rs6040636 Imputed T ADDITIVE 1.31E−05 1.31E−05 1.3748 1.3748 0.9806 0 rs6040636 Imputed T GENOTYPIC 7.73E−06 7.73E−06 2.0134 2.0134 0.9037 0 rs6040636 Imputed T RECESSIVE 6.47E−05 6.47E−05 1.7879 1.7879 0.5965 0 rs6040638 Imputed C ADDITIVE 1.20E−05 1.20E−05 1.3766 1.3766 0.9732 0 rs6040638 Imputed C GENOTYPIC 7.24E−06 7.24E−06 2.0174 2.0174 0.8918 0 rs6040638 Imputed C RECESSIVE 6.47E−05 6.47E−05 1.7879 1.7879 0.5965 0 rs6040644 Imputed A ADDITIVE 1.20E−05 1.20E−05 1.3766 1.3766 0.9732 0 rs6040644 Imputed A GENOTYPIC 7.24E−06 7.24E−06 2.0174 2.0174 0.8918 0 rs6040644 Imputed A RECESSIVE 6.47E−05 6.47E−05 1.7879 1.7879 0.5965 0 rs6040667 Imputed T ADDITIVE 1.20E−05 1.20E−05 1.3804 1.3804 0.9597 0 rs6040667 Imputed T GENOTYPIC 7.88E−06 7.88E−06 2.0249 2.0249 0.8444 0 rs6040667 Imputed T RECESSIVE 7.44E−05 7.44E−05 1.7892 1.7892 0.5844 0 rs6040668 Imputed C ADDITIVE 1.73E−05 1.73E−05 1.373 1.373 0.98 0 rs6040668 Imputed C GENOTYPIC 1.05E−05 1.05E−05 2.0115 2.0115 0.8502 0 rs6040668 Imputed C RECESSIVE 9.40E−05 9.40E−05 1.7793 1.7793 0.5751 0 rs6043066 Genotyped G DOMINANT 9.84E−05 9.84E−05 1.4879 1.4879 0.4214 0 rs6048146 Imputed G DOMINANT 5.02E−05 5.02E−05 2.6243 2.6243 0.8749 0 rs6082725 Genotyped T DOMINANT 5.02E−05 5.02E−05 2.6243 2.6243 0.8749 0 rs6131206 Imputed C ADDITIVE 7.67E−05 7.67E−05 1.3544 1.3544 0.6023 0 rs6131208 Imputed T ADDITIVE 1.43E−05 1.43E−05 1.3763 1.3763 0.9848 0 rs6131208 Imputed T GENOTYPIC 8.33E−06 8.33E−06 2.0252 2.0252 0.879 0 rs6131208 Imputed T RECESSIVE 7.25E−05 7.25E−05 1.7953 1.7953 0.6033 0 rs6134243 Imputed C ADDITIVE 1.20E−05 1.20E−05 1.3766 1.3766 0.9732 0 rs6134243 Imputed C GENOTYPIC 7.24E−06 7.24E−06 2.0174 2.0174 0.8918 0 rs6134243 Imputed C RECESSIVE 6.47E−05 6.47E−05 1.7879 1.7879 0.5965 0 rs6136020 Imputed A DOMINANT 0.001161 0.126 0.6966 0.7316 0.042 68.46 rs613799 Imputed C DOMINANT 7.75E−05 7.75E−05 1.5158 1.5158 0.7849 0 rs644041 Imputed G ADDITIVE 8.78E−05 8.78E−05 1.391 1.391 0.5335 0 rs644041 Imputed G DOMINANT 7.42E−05 7.42E−05 1.5143 1.5143 0.8073 0 rs647645 Imputed C ADDITIVE 6.86E−05 0.001002 0.7509 0.7567 0.2638 24.95 rs647645 Imputed C GENOTYPIC 9.70E−05 0.006546 0.5657 0.581 0.1711 43.36 rs647645 Imputed C RECESSIVE 0.001082 0.1079 0.6612 0.6805 0.034 70.43 rs6495554 Imputed C GENOTYPIC 4.76E−05 4.76E−05 2.9048 2.9048 0.6375 0 rs6495554 Imputed C RECESSIVE 7.67E−05 7.67E−05 2.7833 2.7833 0.6295 0 rs6495555 Imputed C GENOTYPIC 4.76E−05 4.76E−05 2.9048 2.9048 0.6375 0 rs6495555 Imputed C RECESSIVE 7.67E−05 7.67E−05 2.7833 2.7833 0.6295 0 rs6544728 Imputed T DOMINANT 1.47E−05 1.47E−05 1.5526 1.5526 0.4629 0 rs6550705 Imputed C ADDITIVE 0.00038 0.004853 1.3004 1.2925 0.2297 32.02 rs6550705 Imputed C GENOTYPIC 0.0004703 0.0268 1.7552 1.6884 0.1275 51.46 rs6550707 Imputed T GENOTYPIC 0.0005925 0.02351 1.7169 1.6622 0.1452 48.18 rs658108 Imputed A DOMINANT 9.19E−05 9.19E−05 1.4801 1.4801 0.8339 0 rs6593441 Imputed A DOMINANT 8.32E−05 8.32E−05 1.5966 1.5966 0.6727 0 rs668732 Imputed A DOMINANT 0.0007713 0.04322 1.4673 1.4272 0.1016 56.26 rs671041 Imputed A DOMINANT 7.41E−05 7.41E−05 1.4878 1.4878 0.8316 0 rs6719700 Imputed A ADDITIVE 9.48E−05 9.48E−05 1.4547 1.4547 0.8457 0 rs6719700 Imputed A DOMINANT 9.05E−05 9.05E−05 1.5345 1.5345 0.997 0 rs6722640 Imputed T DOMINANT 6.69E−06 6.69E−06 0.6251 0.6251 0.6987 0 rs6743092 Imputed T ADDITIVE 8.16E−05 8.16E−05 1.3286 1.3286 0.8471 0 rs6743092 Imputed T GENOTYPIC 7.98E−05 7.98E−05 1.7638 1.7638 0.836 0 rs6743092 Imputed T RECESSIVE 2.27E−05 2.27E−05 1.6478 1.6478 0.7669 0 rs6744759 Imputed G RECESSIVE 8.79E−05 8.79E−05 1.9877 1.9877 0.536 0 rs6746170 Imputed A DOMINANT 2.07E−05 2.07E−05 1.5394 1.5394 0.5817 0 rs6759922 Imputed A DOMINANT 0.001026 0.0855 0.6912 0.7071 0.0483 66.99 rs6769864 Imputed T GENOTYPIC 0.0004564 0.02145 1.7578 1.6967 0.1428 48.63 rs6773932 Imputed C GENOTYPIC 0.000867 0.04735 1.6964 1.6233 0.1035 55.91 rs6774353 Imputed A GENOTYPIC 0.0005033 0.02669 1.7503 1.6851 0.1298 51.02 rs6781670 Imputed C GENOTYPIC 0.00058 0.0204 1.7388 1.6882 0.1518 46.96 rs6786431 Imputed A GENOTYPIC 0.000867 0.04735 1.6964 1.6233 0.1035 55.91 rs6789091 Imputed T GENOTYPIC 0.000867 0.04735 1.6964 1.6233 0.1035 55.91 rs6791296 Imputed T ADDITIVE 7.12E−05 7.12E−05 0.6329 0.6329 0.9898 0 rs6792662 Imputed G DOMINANT 6.98E−05 6.98E−05 1.6112 1.6112 0.5862 0 rs6797574 Imputed G GENOTYPIC 0.000867 0.04735 1.6964 1.6233 0.1035 55.91 rs6797882 Imputed G GENOTYPIC 0.0008269 0.04785 1.7009 1.6266 0.1009 56.4 rs6805139 Imputed G DOMINANT 3.85E−05 3.85E−05 1.6152 1.6152 0.6499 0 rs6806043 Imputed C ADDITIVE 0.0003052 0.005086 1.306 1.2979 0.2161 34.72 rs6806043 Imputed C GENOTYPIC 0.0004109 0.02711 1.7655 1.6976 0.1213 52.6 rs6850716 Imputed C GENOTYPIC 0.003416 0.1872 2.0499 1.9631 0.0177 75.23 rs6867153 Imputed A RECESSIVE 0.00187 0.191 0.678 0.7117 0.0177 75.21 rs687047 Imputed C ADDITIVE 9.00E−05 9.00E−05 0.6446 0.6446 0.7637 0 rs6871041 Imputed G DOMINANT 2.29E−05 2.29E−05 0.6393 0.6393 0.8477 0 rs688358 Imputed A ADDITIVE 7.44E−05 7.44E−05 0.6401 0.6401 0.8637 0 rs6888012 Imputed A RECESSIVE 0.001885 0.1924 0.6781 0.7121 0.0175 75.29 rs6908481 Imputed C RECESSIVE 5.99E−05 5.99E−05 1.7201 1.7201 0.5809 0 rs7032231 Imputed A ADDITIVE 6.99E−05 6.99E−05 1.352 1.352 0.3922 0 rs7067638 Imputed T DOMINANT 8.99E−05 8.99E−05 1.5963 1.5963 0.7456 0 rs7077799 Imputed A DOMINANT 7.58E−05 7.58E−05 1.4996 1.4996 0.7406 0 rs7082163 Imputed A ADDITIVE 5.34E−05 5.34E−05 1.5444 1.5444 0.4266 0 rs7082163 Imputed A DOMINANT 3.46E−05 3.46E−05 1.641 1.641 0.6461 0 rs7089661 Imputed C DOMINANT 4.97E−05 4.97E−05 1.5023 1.5023 0.7397 0 rs7101319 Imputed C ADDITIVE 5.28E−05 5.28E−05 1.5457 1.5457 0.468 0 rs7101319 Imputed C DOMINANT 3.22E−05 3.22E−05 1.6456 1.6456 0.7067 0 rs710832 Genotyped A GENOTYPIC 6.03E−05 6.03E−05 0.3754 0.3754 0.8143 0 rs710832 Genotyped A RECESSIVE 3.36E−05 3.36E−05 0.3689 0.3689 0.7382 0 rs7134262 Imputed T GENOTYPIC 2.96E−05 2.96E−05 1.9763 1.9763 0.627 0 rs7134262 Imputed T RECESSIVE 1.46E−06 1.46E−06 2.0802 2.0802 0.5227 0 rs7134671 Imputed T GENOTYPIC 0.0002855 0.005252 1.7315 1.725 0.1999 37.89 rs7138300 Imputed C ADDITIVE 2.15E−05 2.15E−05 0.7321 0.7321 0.9128 0 rs7138300 Imputed C DOMINANT 6.73E−05 6.73E−05 0.6474 0.6474 0.8659 0 rs7138300 Imputed C GENOTYPIC 6.26E−05 6.26E−05 0.5503 0.5503 0.7315 0 rs7163931 Imputed G GENOTYPIC 4.76E−05 4.76E−05 2.9048 2.9048 0.6375 0 rs7163931 Imputed G RECESSIVE 7.67E−05 7.67E−05 2.7833 2.7833 0.6295 0 rs7171486 Genotyped G DOMINANT 7.21E−05 7.21E−05 0.6684 0.6684 0.4022 0 rs7172611 Imputed G GENOTYPIC 4.65E−05 4.65E−05 2.9093 2.9093 0.6341 0 rs7172611 Imputed G RECESSIVE 7.67E−05 7.67E−05 2.7833 2.7833 0.6295 0 rs7172689 Imputed T GENOTYPIC 4.65E−05 4.65E−05 2.9093 2.9093 0.6341 0 rs7172689 Imputed T RECESSIVE 7.67E−05 7.67E−05 2.7833 2.7833 0.6295 0 rs7175701 Imputed C GENOTYPIC 9.05E−05 9.05E−05 2.5914 2.5914 0.7706 0 rs7180245 Imputed A GENOTYPIC 4.65E−05 4.65E−05 2.9093 2.9093 0.6341 0 rs7180245 Imputed A RECESSIVE 7.67E−05 7.67E−05 2.7833 2.7833 0.6295 0 rs7220603 Genotyped A ADDITIVE 0.02391 0.5255 0.8346 0.8604 0.0003 87.88 rs7282518 Imputed T ADDITIVE 0.0002567 0.008981 1.453 1.4275 0.1773 42.19 rs7283476 Imputed T ADDITIVE 7.31E−05 7.31E−05 0.4402 0.4402 0.566 0 rs7283476 Imputed T DOMINANT 3.52E−05 3.52E−05 0.4064 0.4064 0.4235 0 rs7295817 Imputed C GENOTYPIC 7.67E−05 7.67E−05 0.5483 0.5483 0.4481 0 rs7298255 Imputed A ADDITIVE 3.91E−05 3.91E−05 0.7439 0.7439 0.9855 0 rs7298255 Imputed A DOMINANT 6.89E−05 6.89E−05 0.65 0.65 0.7442 0 rs7305832 Imputed C GENOTYPIC 2.48E−05 2.48E−05 1.9853 1.9853 0.5975 0 rs7305832 Imputed C RECESSIVE 1.31E−06 1.31E−06 2.0856 2.0856 0.5058 0 rs7331467 Imputed A GENOTYPIC 0.004523 0.2685 1.5788 1.4648 0.0124 77.22 rs7392620 Imputed C ADDITIVE 8.20E−05 8.20E−05 0.7361 0.7361 0.6441 0 rs742827 Imputed A ADDITIVE 8.46E−06 8.46E−06 1.3961 1.3961 0.9898 0 rs742827 Imputed A GENOTYPIC 7.47E−06 7.47E−06 2.0465 2.0465 0.8196 0 rs742827 Imputed A RECESSIVE 9.50E−05 9.50E−05 1.7817 1.7817 0.5729 0 rs7446891 Imputed G DOMINANT 2.31E−05 2.31E−05 0.6505 0.6505 0.8585 0 rs7448641 Imputed C ADDITIVE 0.002876 0.1046 0.5269 0.4225 0.0055 80.81 rs7448641 Imputed C DOMINANT 0.005931 0.1502 0.5204 0.4449 0.0058 80.6 rs7484728 Imputed T GENOTYPIC 0.000266 0.005086 1.736 1.7289 0.1995 37.97 rs7499402 Genotyped A ADDITIVE 7.41E−05 7.41E−05 1.7018 1.7018 0.5603 0 rs7529851 Imputed A ADDITIVE 7.64E−05 7.64E−05 0.7438 0.7438 0.6011 0 rs7529851 Imputed A GENOTYPIC 8.65E−05 8.65E−05 0.5413 0.5413 0.7417 0 rs7573951 Imputed G ADDITIVE 0.0009373 0.04269 0.7841 0.7912 0.0927 57.96 rs7599198 Imputed T DOMINANT 0.0005956 0.01854 0.6706 0.6818 0.1584 45.74 rs7600050 Imputed C ADDITIVE 6.57E−05 6.57E−05 1.3535 1.3535 0.6858 0 rs7607712 Imputed T ADDITIVE 6.22E−05 6.22E−05 1.4258 1.4258 0.846 0 rs7607712 Imputed T DOMINANT 8.77E−05 8.77E−05 1.4994 1.4994 0.9843 0 rs7613492 Imputed G GENOTYPIC 0.0004892 0.02726 1.756 1.6897 0.1265 51.64 rs7621663 Imputed G ADDITIVE 0.0002694 0.00593 1.3166 1.3062 0.1995 37.97 rs7621663 Imputed G GENOTYPIC 0.0002328 0.03627 1.849 1.7635 0.0774 60.91 rs7621663 Imputed G RECESSIVE 0.001212 0.0888 1.6632 1.577 0.0599 64.48 rs7626584 Imputed G ADDITIVE 9.18E−05 9.18E−05 0.5375 0.5375 0.6785 0 rs7684899 Imputed C ADDITIVE 9.76E−05 9.76E−05 0.6985 0.6985 0.7616 0 rs7684899 Imputed C DOMINANT 6.37E−06 6.37E−06 0.6204 0.6204 0.6462 0 rs7701604 Imputed G ADDITIVE 0.002876 0.1046 0.5269 0.4225 0.0055 80.81 rs7701604 Imputed G DOMINANT 0.005931 0.1502 0.5204 0.4449 0.0058 80.6 rs7703676 Imputed C ADDITIVE 0.002876 0.1046 0.5269 0.4225 0.0055 80.81 rs7703676 Imputed C DOMINANT 0.005931 0.1502 0.5204 0.4449 0.0058 80.6 rs7708491 Imputed C RECESSIVE 0.002355 0.1727 0.6852 0.7155 0.0267 72.41 rs7711358 Imputed A DOMINANT 1.88E−05 1.88E−05 0.6481 0.6481 0.8316 0 rs7719448 Imputed G RECESSIVE 0.002108 0.2193 0.6815 0.7163 0.012 77.4 rs7724761 Imputed T RECESSIVE 0.001686 0.19 0.6737 0.7045 0.0154 76.06 rs7742476 Imputed T DOMINANT 0.0001163 0.0001163 1.5074 1.5074 0.3696 0 rs7762993 Imputed A ADDITIVE 0.0003347 0.004615 1.3933 1.3716 0.2531 27.21 rs7762993 Imputed A DOMINANT 9.42E−05 0.01287 1.507 1.4653 0.1301 50.97 rs7767265 Imputed G ADDITIVE 1.59E−05 0.000172 1.4422 1.4296 0.296 17.87 rs7767265 Imputed G DOMINANT 6.30E−06 0.003597 1.5886 1.5475 0.1294 51.09 rs7768128 Imputed G RECESSIVE 9.37E−05 9.37E−05 0.3867 0.3867 0.8076 0 rs7771264 Imputed T DOMINANT 0.00106 0.07475 0.7141 0.7193 0.046 67.53 rs7773151 Genotyped C DOMINANT 0.000959 0.06482 0.7135 0.7189 0.055 65.52 rs7773210 Genotyped A DOMINANT 0.0008239 0.06306 0.7105 0.7165 0.0539 65.76 rs7808536 Imputed G DOMINANT 8.84E−05 8.84E−05 1.5126 1.5126 0.3832 0 rs7843510 Genotyped G DOMINANT 0.0008947 0.03339 1.418 1.392 0.1219 52.48 rs7894867 Imputed T DOMINANT 7.78E−05 7.78E−05 1.6032 1.6032 0.7494 0 rs7921834 Imputed C DOMINANT 5.41E−05 5.41E−05 1.4996 1.4996 0.7497 0 rs7939893 Imputed C ADDITIVE 8.65E−05 8.65E−05 0.7474 0.7474 0.6566 0 rs7939893 Imputed C DOMINANT 9.08E−06 9.08E−06 0.6395 0.6395 0.3716 0 rs7944513 Imputed T GENOTYPIC 1.13E−05 1.13E−05 2.6894 2.6894 0.5228 0 rs7944513 Imputed T RECESSIVE 3.32E−05 3.32E−05 2.5007 2.5007 0.3973 0 rs7949720 Imputed G ADDITIVE 0.01083 0.46 0.7505 0.8044 0.0015 84.54 rs7949720 Imputed G DOMINANT 0.009467 0.4625 0.7247 0.7836 0.0012 85.09 rs7955901 Imputed C ADDITIVE 3.31E−05 3.31E−05 0.7403 0.7403 0.9802 0 rs7955901 Imputed C DOMINANT 6.34E−05 6.34E−05 0.6473 0.6473 0.8105 0 rs7956274 Imputed T ADDITIVE 2.32E−05 2.32E−05 0.7349 0.7349 0.9325 0 rs7956274 Imputed T DOMINANT 3.52E−05 3.52E−05 0.6366 0.6366 0.8605 0 rs7956274 Imputed T GENOTYPIC 7.30E−05 7.30E−05 0.5575 0.5575 0.7749 0 rs7957932 Imputed G ADDITIVE 5.54E−05 5.54E−05 0.7481 0.7481 0.9512 0 rs7957932 Imputed G DOMINANT 3.06E−05 3.06E−05 0.6329 0.6329 0.8798 0 rs7984504 Imputed C GENOTYPIC 0.002726 0.1381 1.6689 1.6043 0.0349 70.18 rs7999518 Imputed A RECESSIVE 2.72E−05 2.72E−05 0.5848 0.5848 0.4425 0 rs8026245 Imputed G GENOTYPIC 7.79E−05 7.79E−05 2.665 2.665 0.6771 0 rs8026245 Imputed G RECESSIVE 8.54E−05 8.54E−05 2.6107 2.6107 0.6577 0 rs8060725 Genotyped A ADDITIVE 9.99E−05 9.99E−05 0.7239 0.7239 0.8435 0 rs8103016 Genotyped A ADDITIVE 1.98E−05 1.98E−05 1.4503 1.4503 0.4547 0 rs8103016 Genotyped A DOMINANT 2.45E−05 2.45E−05 1.5482 1.5482 0.694 0 rs8104182 Imputed G ADDITIVE 3.24E−05 3.24E−05 1.4421 1.4421 0.671 0 rs8104182 Imputed G DOMINANT 4.77E−05 4.77E−05 1.5265 1.5265 0.7687 0 rs8129461 Imputed G ADDITIVE 3.70E−05 3.70E−05 0.4263 0.4263 0.5257 0 rs8129461 Imputed G DOMINANT 1.72E−05 1.72E−05 0.3933 0.3933 0.3761 0 rs8130021 Imputed G ADDITIVE 7.55E−05 7.55E−05 0.4409 0.4409 0.5674 0 rs8130021 Imputed G DOMINANT 3.64E−05 3.64E−05 0.4071 0.4071 0.4256 0 rs879961 Imputed T ADDITIVE 0.002059 0.2563 0.7763 0.8081 0.0066 80.11 rs879961 Imputed T DOMINANT 0.001811 0.2398 0.7301 0.7595 0.0059 80.5 rs906353 Imputed A DOMINANT 0.004624 0.2465 0.7527 0.7852 0.0165 75.63 rs915491 Imputed C DOMINANT 8.48E−05 8.48E−05 1.4838 1.4838 0.752 0 rs915493 Imputed T DOMINANT 8.48E−05 8.48E−05 1.4838 1.4838 0.752 0 rs915494 Imputed A ADDITIVE 7.86E−05 7.86E−05 1.3658 1.3658 0.8997 0 rs915494 Imputed A DOMINANT 2.62E−05 2.62E−05 1.5383 1.5383 0.8223 0 rs917295 Imputed G DOMINANT 1.82E−05 1.82E−05 0.647 0.647 0.881 0 rs9284851 Imputed A GENOTYPIC 0.0007416 0.04371 1.7018 1.6321 0.1049 55.65 rs9293464 Imputed T RECESSIVE 0.00171 0.194 0.6758 0.7101 0.0158 75.88 rs9295154 Genotyped G DOMINANT 7.58E−05 7.58E−05 1.5572 1.5572 0.5416 0 rs9310221 Imputed A DOMINANT 0.001363 0.158 1.4328 1.353 0.0322 70.9 rs9310699 Genotyped T GENOTYPIC 0.00058 0.0204 1.7388 1.6882 0.1518 46.96 rs9310700 Imputed C ADDITIVE 0.0003931 0.005395 1.3049 1.2966 0.2216 33.63 rs9310700 Imputed C GENOTYPIC 0.0003693 0.03198 1.8013 1.7265 0.1006 56.46 rs9310701 Imputed G GENOTYPIC 0.0005775 0.02214 1.7187 1.6652 0.1488 47.51 rs9310704 Imputed G GENOTYPIC 0.000597 0.04612 1.7265 1.6511 0.0921 58.07 rs9319185 Imputed C GENOTYPIC 0.003084 0.2063 1.6765 1.5851 0.0147 76.3 rs9319186 Imputed T GENOTYPIC 0.002645 0.1394 1.6843 1.6228 0.0311 71.19 rs9327555 Imputed T DOMINANT 2.31E−05 2.31E−05 0.6505 0.6505 0.8585 0 rs9403367 Imputed C DOMINANT 0.0008239 0.06306 0.7105 0.7165 0.0539 65.76 rs9419608 Imputed G RECESSIVE 0.007479 0.5441 1.3778 1.2224 0.0008 85.89 rs9426437 Imputed T DOMINANT 0.0007324 0.08646 0.6967 0.7283 0.0587 64.74 rs9454967 Imputed G DOMINANT 0.0008641 0.05434 1.5996 1.5843 0.071 62.2 rs9635511 Imputed T DOMINANT 0.0001778 0.001844 0.6752 0.6837 0.2682 24.02 rs966583 Imputed A ADDITIVE 1.48E−05 1.48E−05 0.725 0.725 0.8807 0 rs966583 Imputed A DOMINANT 7.60E−06 7.60E−06 0.626 0.626 0.8999 0 rs980263 Imputed T GENOTYPIC 0.000492 0.02264 1.7325 1.6751 0.1412 48.92 rs980264 Imputed T GENOTYPIC 0.000492 0.02264 1.7325 1.6751 0.1412 48.92 rs9812206 Imputed G ADDITIVE 9.92E−05 0.03775 0.6049 0.6297 0.0642 63.57 rs9812206 Imputed G DOMINANT 0.0001008 0.04527 0.592 0.6174 0.049 66.85 rs9813552 Imputed G ADDITIVE 0.0004552 0.03885 0.6393 0.6583 0.0966 57.21 rs9813552 Imputed G DOMINANT 0.0005252 0.05892 0.629 0.6531 0.0685 62.71 rs9815037 Imputed T ADDITIVE 0.0003061 0.04794 0.6241 0.6399 0.0613 64.17 rs9815037 Imputed T DOMINANT 0.0002862 0.06392 0.6094 0.6301 0.0425 68.34 rs9819583 Imputed T GENOTYPIC 0.0005347 0.02047 1.7449 1.6926 0.1487 47.53 rs9825349 Imputed A ADDITIVE 0.0003046 0.04763 0.624 0.6401 0.062 64.03 rs9825349 Imputed A DOMINANT 0.0002859 0.0639 0.6094 0.6304 0.0427 68.28 rs9833118 Imputed G ADDITIVE 0.0004117 0.006196 1.3 1.293 0.2139 35.15 rs9833118 Imputed G GENOTYPIC 0.0004555 0.02726 1.7602 1.6961 0.123 52.28 rs9834217 Imputed T ADDITIVE 0.0002698 0.03497 0.6218 0.6356 0.0789 60.62 rs9834217 Imputed T DOMINANT 0.0002509 0.0487 0.607 0.6256 0.0556 65.39 rs9838563 Imputed C GENOTYPIC 0.0004051 0.008482 1.7473 1.7073 0.2054 36.83 rs9840460 Imputed T ADDITIVE 0.0002575 0.03523 0.6208 0.6345 0.0768 61.03 rs9840460 Imputed T DOMINANT 0.0002389 0.04871 0.6059 0.6244 0.0543 65.67 rs9840756 Imputed A ADDITIVE 0.0002251 0.02861 0.618 0.6307 0.0873 58.99 rs9840756 Imputed A DOMINANT 0.0002087 0.04085 0.603 0.6206 0.0622 63.99 rs9847999 Imputed C GENOTYPIC 0.0009186 0.04314 1.6854 1.6208 0.1128 54.17 rs9864769 Imputed C GENOTYPIC 0.0005775 0.02214 1.7187 1.6652 0.1488 47.51 rs9866421 Genotyped C RECESSIVE 8.99E−05 8.99E−05 0.5978 0.5978 0.7628 0 rs987296 Imputed T GENOTYPIC 0.0006125 0.02328 1.7346 1.6817 0.1438 48.43 rs9881685 Imputed A ADDITIVE 9.85E−05 0.03734 0.6048 0.6295 0.0647 63.48 rs9881685 Imputed A DOMINANT 0.0001 0.04485 0.5918 0.6172 0.0494 66.76 rs992695 Imputed C ADDITIVE 0.002041 0.2367 0.7764 0.8067 0.0089 78.81 rs992695 Imputed C DOMINANT 0.001822 0.2163 0.7308 0.7583 0.009 78.78 rs9936999 Imputed G DOMINANT 0.004771 0.2439 1.4561 1.3895 0.0142 76.48

TABLE 19 CARE allele A1 allele A2 Placebo OR OR SNP (non-ref) (ref) P.R. OR.R. Prava Count count OR L95 U95 P value rs11556924 A G 0.00196 1.33 42/141/117 43/157/182 1.26 1.01 1.58 0.0449 WOSCOPS Prava Placebo OR OR SNP Count Count OR L95 U95 P value Endpoint Model rs11556924 28/79/52 22/104/98 1.48 1.09 2.02 0.0123 CHD add

TABLE 20 P_(—) GENO mAF GENO_(—) EVENTS TOTAL_(—) HR_(—) L95_(—) U95_(—) P_(—) INT_(—) PLACE EVENTS_(—) TOTAL_(—) HR_(—) SNP hCV # SNP rs # Chrom CEU MODE RESP STATIN RESP RESP RESP RESP RESP RESP RESP BO PLACEBO PLACEBO PLACEBO hCV11841860 rs10757278 9p21 0.5 GEN GG Pravastatin 24 410 1.08 0.602 1.94 0.7931 0.1691 GG 21 390 1.06 hCV11841860 rs10757278 9p21 0.5 GEN GG Placebo 21 390 ref . . . 0.1691 . . . hCV11841860 rs10757278 9p21 0.5 GEN GA Pravastatin 27 653 0.54 0.34  0.86 0.0096 0.1691 GA 52 689 1.47 hCV11841860 rs10757278 9p21 0.5 GEN GA Placebo 52 689 ref . . . 0.1691 . . . hCV11841860 rs10757278 9p21 0.5 GEN AA Pravastatin 15 334 0.9  0.438 1.84 0.7666 0.1691 AA 15 289 ref hCV11841860 rs10757278 9p21 0.5 GEN AA Placebo 15 289 ref . . . 0.1691 . . . hCV11841860 rs10757278 9p21 0.5 DOM GA + GG Pravastatin 51 1063 0.7  0.491 1.01 0.0533 0.6037 GA + GG 73 1079  1.32 hCV11841860 rs10757278 9p21 0.5 DOM GA + GG Placebo 73 1079 ref . . . 0.6037 . . . hCV11841860 rs10757278 9p21 0.5 REC GA + AA Pravastatin 42 987 0.62 0.42  0.91 0.0146 0.118  GG 21 390 0.8  hCV11841860 rs10757278 9p21 0.5 REC GA + AA Placebo 67 978 ref . . . 0.118  . . . hCV1754666 rs1333049 9p21 0.492 GEN GG Pravastatin 16 335 0.96 0.474 1.94 0.9086 0.1288 GG 15 291 0.95 hCV1754666 rs1333049 9p21 0.492 GEN GG Placebo 15 291 ref . . . 0.1288 . . . hCV1754666 rs1333049 9p21 0.492 GEN GC Pravastatin 27 659 0.54 0.336 0.85 0.0085 0.1288 GC 52 689 1.4  hCV1754666 rs1333049 9p21 0.492 GEN GC Placebo 52 689 ref . . . 0.1288 . . . hCV1754666 rs1333049 9p21 0.492 GEN CC Pravastatin 24 405 1.11 0.616 1.99 0.7346 0.1288 CC 21 393 ref hCV1754666 rs1333049 9p21 0.492 GEN CC Placebo 21 393 ref . . . 0.1288 . . . hCV1754666 rs1333049 9p21 0.492 DOM GC + GG Pravastatin 43 994 0.63 0.429 0.92 0.018  0.1139 GC + GG 67 980 1.26 hCV1754666 rs1333049 9p21 0.492 DOM GC + GG Placebo 67 980 ref . . . 0.1139 . . . hCV1754666 rs1333049 9p21 0.492 REC GC + CC Pravastatin 51 1064 0.7  0.493 1.01 0.0549 0.4877 GG 15 291 0.75 hCV1754666 rs1333049 9p21 0.492 REC GC + CC Placebo 73 1082 ref . . . 0.4877 . . . hCV12094896 rs12425791 12p13 0.175 GEN AA Pravastatin 2 60 0.28 0.058 1.35 0.1119 0.1255 AA  7  60 2.18 hCV12094896 rs12425791 12p13 0.175 GEN AA Placebo 7 60 ref . . . 0.1255 . . . hCV12094896 rs12425791 12p13 0.175 GEN AG Pravastatin 22 485 0.56 0.331 0.96 0.0353 0.1255 AG 35 442 1.51 hCV12094896 rs12425791 12p13 0.175 GEN AG Placebo 35 442 ref . . . 0.1255 . . . hCV12094896 rs12425791 12p13 0.175 GEN GG Pravastatin 43 852 0.95 0.628 1.44 0.8138 0.1255 GG 46 867 ref hCV12094896 rs12425791 12p13 0.175 GEN GG Placebo 46 867 ref . . . 0.1255 . . . hCV12094896 rs12425791 12p13 0.175 DOM AG + AA Pravastatin 24 545 0.52 0.314 0.86 0.0101 0.0653 AG + AA 42 502 1.59 hCV12094896 rs12425791 12p13 0.175 DOM AG + AA Placebo 42 502 ref . . . 0.0653 . . . hCV12094896 rs12425791 12p13 0.175 REC AG + GG Pravastatin 65 1337 0.78 0.565 1.09 0.1411 0.1736 AA  7  60 1.86 hCV12094896 rs12425791 12p13 0.175 REC AG + GG Placebo 81 1309 ref . . . 0.1736 . . . hCV1665834 rs11833579 12p13 0.225 GEN AA Pravastatin 3 99 0.26 0.072 0.95 0.0417 0.1885 AA 10  91 2   hCV1665834 rs11833579 12p13 0.225 GEN AA Placebo 10 91 ref . . . 0.1885 . . . hCV1665834 rs11833579 12p13 0.225 GEN AG Pravastatin 29 566 0.75 0.46  1.22 0.2425 0.1885 AG 37 541 1.24 hCV1665834 rs11833579 12p13 0.225 GEN AG Placebo 37 541 ref . . . 0.1885 . . . hCV1665834 rs11833579 12p13 0.225 GEN GG Pravastatin 35 730 0.86 0.55  1.36 0.5258 0.1885 GG 41 739 ref hCV1665834 rs11833579 12p13 0.225 GEN GG Placebo 41 739 ref . . . 0.1885 . . . hCV1665834 rs11833579 12p13 0.225 DOM AG + AA Pravastatin 32 665 0.64 0.409 1   0.0523 0.3522 AG + AA 47 632 1.35 hCV1665834 rs11833579 12p13 0.225 DOM AG + AA Placebo 47 632 ref . . . 0.3522 . . . hCV1665834 rs11833579 12p13 0.225 REC AG + GG Pravastatin 64 1296 0.81 0.581 1.13 0.2091 0.0756 AA 10  91 1.81 hCV1665834 rs11833579 12p13 0.225 REC AG + GG Placebo 78 1280 ref . . . 0.0756 . . . P_(—) P_(—) L95_(—) U95_(—) P_(—) DF2_(—) GENO_(—) EVENTS_(—) TOTAL_(—) HR_(—) L95_(—) U95_(—) P_(—) DF2_(—) SNP hCV # SNP rs # PLACEBO PLACEBO PLACEBO PLACEBO ALL ALL ALL ALL ALL ALL ALL ALL hCV11841860 rs10757278 0.545 2.052 0.8676 0.2663 GG 45 800 1.18 0.744 1.876 0.479  0.639 hCV11841860 rs10757278 . . . . . . . . . . . hCV11841860 rs10757278 0.826 2.607 0.1905 0.2663 GA 79 1342  1.22 0.803 1.862 0.3478 0.639 hCV11841860 rs10757278 . . . . . . . . . . . hCV11841860 rs10757278 . . . 0.2663 AA 30 623 ref . . . 0.639 hCV11841860 rs10757278 . . . . . . . . . . . hCV11841860 rs10757278 0.758 2.302 0.3269 . GA + GG 124  2142  1.21 0.81  1.8  0.3537 . hCV11841860 rs10757278 . . . . . . . . . . . hCV11841860 rs10757278 0.488 1.3  0.3624 . GG 45 800 1.03 0.725 1.451 0.8868 . hCV11841860 rs10757278 . . . . . . . . . . . hCV1754666 rs1333049 0.488 1.836 0.8702 0.2539 GG 31 626 0.87 0.549 1.371 0.5427 0.727 hCV1754666 rs1333049 . . . . . . . . . . . hCV1754666 rs1333049 0.842 2.319 0.1961 0.2539 GC 79 1348  1.03 0.711 1.478 0.8939 0.727 hCV1754666 rs1333049 . . . . . . . . . . . hCV1754666 rs1333049 . . . 0.2539 CC 45 798 ref . . . 0.727 hCV1754666 rs1333049 . . . . . . . . . . . hCV1754666 rs1333049 0.773 2.061 0.3517 . GC + GG 110  1974  0.98 0.689 1.379 0.8869 . hCV1754666 rs1333049 . . . . . . . . . . . hCV1754666 rs1333049 0.433 1.316 0.3212 . GG 31 626 0.85 0.576 1.266 0.4317 . hCV1754666 rs1333049 . . . . . . . . . . . hCV12094896 rs12425791 0.984 4.831 0.0547 0.0584 AA  9 120 1.42 0.715 2.817 0.317  0.421 hCV12094896 rs12425791 . . . . . . . . . . . hCV12094896 rs12425791 0.971 2.339 0.0674 0.0584 AG 57 927 1.19 0.854 1.66  0.3045 0.421 hCV12094896 rs12425791 . . . . . . . . . . . hCV12094896 rs12425791 . . . 0.0584 GG 89 1719  ref . . . 0.421 hCV12094896 rs12425791 . . . . . . . . . . . hCV12094896 rs12425791 1.046 2.414 0.0301 . AG + AA 66 1047  1.22 0.885 1.673 0.2267 . hCV12094896 rs12425791 . . . . . . . . . . . hCV12094896 rs12425791 0.861 4.034 0.1142 . AA  9 120 1.33 0.679 2.609 0.4055 . hCV12094896 rs12425791 . . . . . . . . . . . hCV1665834 rs11833579 1    3.985 0.05  0.1371 AA 13 190 1.3  0.721 2.339 0.3837 0.555 hCV1665834 rs11833579 . . . . . . . . . . . hCV1665834 rs11833579 0.795 1.933 0.344  0.1371 AG 66 1107  1.15 0.83  1.605 0.3942 0.555 hCV1665834 rs11833579 . . . . . . . . . . . hCV1665834 rs11833579 . . . 0.1371 GG 76 1469  ref . . . 0.555 hCV1665834 rs11833579 . . . . . . . . . . . hCV1665834 rs11833579 0.887 2.049 0.1622 . AG + AA 79 1297  1.18 0.858 1.612 0.3124 . hCV1665834 rs11833579 . . . . . . . . . . . hCV1665834 rs11833579 0.939 3.503 0.0764 . AA 13 190 1.22 0.69  2.15  0.4957 . hCV1665834 rs11833579 . . . . . . . . . . .

TABLE 21 P_(—) GENO_(—) EVENTS_(—) TOTAL_(—) HR_(—) L95_(—) U95_(—) P_(—) INT_(—) GENO_(—) SNP hCV # SNP rs # MODE RESP STATIN RESP RESP RESP RESP RESP RESP RESP PLACEBO hCV2652047 rs873134 GEN CC Pravastatin 27 354 2.01 1.036 3.89  0.0391 0.00164 CC hCV2652047 rs873134 GEN CC Placebo 13 338 ref . . . 0.00164 hCV2652047 rs873134 GEN CT Pravastatin 24 680 0.5  0.308 0.818 0.0057 0.00164 CT hCV2652047 rs873134 GEN CT Placebo 49 697 ref . . . 0.00164 hCV2652047 rs873134 GEN TT Pravastatin 16 366 0.54 0.291 1.01  0.0538 0.00164 TT hCV2652047 rs873134 GEN TT Placebo 26 336 ref . . . 0.00164 hCV2652047 rs873134 DOM CT + CC Pravastatin 51 1034 0.83 0.571 1.199 0.3163 0.25372 CT + CC hCV2652047 rs873134 DOM CT + CC Placebo 62 1035 ref . . . 0.25372 hCV2652047 rs873134 REC CT + TT Pravastatin 40 1046 0.52 0.355 0.765 0.0009 0.00037 CC hCV2652047 rs873134 REC CT + TT Placebo 75 1033 ref . . . 0.00037 P_(—) EVENTS_(—) TOTAL_(—) HR_(—) L95_(—) U95_(—) P_(—) DF2_(—) GENO_(—) SNP hCV # SNP rs # PLACEBO PLACEBO PLACEBO PLACEBO PLACEBO PLACEBO PLACEBO ALL hCV2652047 rs873134 13 338 0.48 0.248 0.939 0.032  0.0851 CC hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134 49 697 0.89 0.551 1.428 0.6225 0.0851 CT hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134 26 336 ref . . . 0.0851 TT hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134 62 1035  0.75 0.477 1.193 0.2284 . CT + CC hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134 13 338 0.52 0.29  0.942 0.0308 . CC hCV2652047 rs873134 . . . . . . . P_(—) HW EVENTS_(—) TOTAL_(—) HR_(—) L95_(—) U95_(—) P_(—) DF2_(—) (ALL) SNP hCV # SNP rs # ALL ALL ALL ALL ALL ALL ALL pExact hCV2652047 rs873134 40 692 0.96 0.626 1.488 0.8714 0.8089 0.761 hCV2652047 rs873134 . . . . . . . 0.761 hCV2652047 rs873134 73 1377  0.89 0.607 1.298 0.539  0.8089 0.761 hCV2652047 rs873134 . . . . . . . 0.761 hCV2652047 rs873134 42 702 ref . . . 0.8089 0.761 hCV2652047 rs873134 . . . . . . . 0.761 hCV2652047 rs873134 113  2069  0.91 0.641 1.302 0.6173 . 0.761 hCV2652047 rs873134 . . . . . . . 0.761 hCV2652047 rs873134 40 692 1.04 0.728 1.494 0.8199 . 0.761 hCV2652047 rs873134 . . . . . . . 0.761

TABLE 22 P_(—) GENO_(—) EVENTS_(—) TOTAL_(—) HR_(—) L95_(—) U95_(—) P_(—) INT_(—) GENO_(—) SNP hCV # SNP rs # MODE RESP STATIN RESP RESP RESP RESP RESP RESP RESP PLACEBO hCV2652047 rs873134 GEN TT Pravastatin 25 364 0.57 0.339 0.952 0.0317 0.05825 TT hCV2652047 rs873134 GEN TT Placebo 37 333 ref . . . 0.05825 hCV2652047 rs873134 GEN TC Pravastatin 63 676 1   0.705 1.405 0.9783 0.05825 TC hCV2652047 rs873134 GEN TC Placebo 67 693 ref . . . 0.05825 hCV2652047 rs873134 GEN CC Pravastatin 23 352 0.48 0.29  0.809 0.0056 0.05825 CC hCV2652047 rs873134 GEN CC Placebo 42 335 ref . . . 0.05825 hCV2652047 rs873134 DOM TC + TT Pravastatin 88 1040 0.85 0.64  1.133 0.2714 0.06887 TC + TT hCV2652047 rs873134 DOM TC + TT Placebo 104 1026 ref . . . 0.06887 P_(—) EVENTS_(—) TOTAL_(—) HR_(—) L95_(—) U95_(—) P_(—) DF2_(—) GENO_(—) SNP hCV # SNP rs # PLACEBO PLACEBO PLACEBO PLACEBO PLACEBO PLACEBO PLACEBO ALL hCV2652047 rs873134 37 333 0.87 0.555 1.349 0.5232 0.3415 TT hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134 67 693 0.75 0.509 1.105 0.1454 0.3415 TC hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134 42 335 ref . . . 0.3415 CC hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134 104  1026  0.79 0.549 1.128 0.1924 . TC + TT hCV2652047 rs873134 . . . . . . . P_(—) EVENTS_(—) TOTAL_(—) HR_(—) L95_(—) U95_(—) P_(—) DF2_(—) SNP hCV # SNP rs # ALL ALL ALL ALL ALL ALL ALL hCV2652047 rs873134  62  697 0.93 0.654 1.313 0.6696 0.8281 hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134 130 1369 1.02 0.756 1.372 0.9047 0.8281 hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134  65  687 ref . . . 0.8281 hCV2652047 rs873134 . . . . . . . hCV2652047 rs873134 192 2066 0.99 0.745 1.308 0.9269 . hCV2652047 rs873134 . . . . . . . 

What is claimed is:
 1. A method for reducing risk of coronary heart disease (CHD) in a human, the method comprising: a) receiving an identification of a human as being responsive to pravastatin treatment for reducing their CHD risk due to having a polymorphism rs13279522 in gene DNAJC5B comprising C at position 101 of SEQ ID NO:1284 or G at its complement; and b) administering pravastatin to said human.
 2. The method of claim 1, wherein said human is homozygous for said C or said G.
 3. The method of claim 1, wherein said human is heterozygous for said C or said G.
 4. The method of claim 1, wherein said CHD is myocardial infarction. 